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Journal articles on the topic 'Diabetic neuropathy in rat'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Islam, Md Shahidul. "Animal Models of Diabetic Neuropathy: Progress Since 1960s." Journal of Diabetes Research 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/149452.

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Diabetic or peripheral diabetic neuropathy (PDN) is one of the major complications among some other diabetic complications such as diabetic nephropathy, diabetic retinopathy, and diabetic cardiomyopathy. The use of animal models in the research of diabetes and diabetic complications is very common when rats and mice are most commonly used for many reasons. A numbers of animal models of diabetic and PDN have been developed in the last several decades such as streptozotocin-induced diabetic rat models, conventional or genetically modified or high-fat diet-fed C57BL/Ks (db/db) mice models, strept

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2

Sasase, Tomohiko. "Diabetic Neuropathy in Spontaneously Diabetic Torii Rat." Open Diabetes Journal 4, no. 1 (2011): 50–54. http://dx.doi.org/10.2174/1876524601104010050.

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3

Sasase, Tomohiko, Takeshi Ohta, Taku Masuyama, Norihide Yokoi, Akihiro Kakehashi, and Masami Shinohara. "The Spontaneously Diabetic Torii Rat: An Animal Model of Nonobese Type 2 Diabetes with Severe Diabetic Complications." Journal of Diabetes Research 2013 (2013): 1–12. http://dx.doi.org/10.1155/2013/976209.

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The Spontaneously Diabetic Torii (SDT) rat is an inbred strain of Sprague-Dawley rat and recently is established as a nonobese model of type 2 diabetes (T2D). Male SDT rats show high plasma glucose levels (over 700 mg/dL) by 20 weeks. Male SDT rats show pancreatic islet histopathology, including hemorrhage in pancreatic islets and inflammatory cell infiltration with fibroblasts. Prior to the onset of diabetes, glucose intolerance with hypoinsulinemia is also observed. As a result of chronic severe hyperglycemia, the SDT rats develop profound complications. In eyes, retinopathy, cataract, and n

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4

Kemmochi, Yusuke, Kenji Fukui, Mimi Maki, et al. "Metabolic Disorders and Diabetic Complications in Spontaneously Diabetic ToriiLeprfaRat: A New Obese Type 2 Diabetic Model." Journal of Diabetes Research 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/948257.

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Spontaneously Diabetic ToriiLeprfa(SDT fatty) rat, established by introducing thefaallele of the Zucker fatty rat into SDT rat genome, is a new model of obese type 2 diabetes. Both male and female SDT fatty rats show overt obesity, and hyperglycemia and hyperlipidemia are observed at a young age as compared with SDT rats. With early incidence of diabetes mellitus, diabetic complications, such as nephropathy, retinopathy, and neuropathy, in SDT fatty rats were seen at younger ages compared to those in the SDT rats. In this paper, we overview pathophysiological features in SDT fatty rats and als

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Shayea, Abdulaziz M. F., Alyaa M. A. Mousa, Waleed M. Renno, Mohammed Shaban Nadar, Bedoor Qabazard, and Mariam H. M. Yousif. "Chronic Treatment With Hydrogen Sulfide Donor GYY4137 Mitigates Microglial and Astrocyte Activation in the Spinal Cord of Streptozotocin-Induced Diabetic Rats." Journal of Neuropathology & Experimental Neurology 79, no. 12 (2020): 1320–43. http://dx.doi.org/10.1093/jnen/nlaa127.

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Abstract Long-term diabetic patients suffer immensely from diabetic neuropathy. This study was designed to investigate the effects of hydrogen sulfide (H2S) on peripheral neuropathy, activation of microglia, astrocytes, and the cascade secretion of proinflammatory cytokines in the streptozotocin (STZ)-induced peripheral diabetic neuropathy rat model. STZ-induced diabetic rats were treated with the water-soluble, slow-releasing H2S donor GYY4137 (50 mg/kg; i.p.) daily for 4 weeks. Antiallodynic/antihyperalgesic activities were evaluated using different tests and histopathological changes and th

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6

McVary, K. T., C. H. Rathnau, and K. E. McKenna. "Sexual dysfunction in the diabetic BB/WOR rat: a role of central neuropathy." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 272, no. 1 (1997): R259—R267. http://dx.doi.org/10.1152/ajpregu.1997.272.1.r259.

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The pathophysiological mechanisms of diabetic impotence remain obscure. We have presented an analysis of sexual function in a diabetic rat (BB/WOR) model characterized by diffuse neuropathic changes without a confounding vasculopathy that allows us to define the neural components of erectile failure. Copulatory behavioral testing demonstrated that diabetic males were severely impaired: the controls mounted three times more than the diabetics and had about one-half the latency to first mount. The diabetics had about one-fourth the number of intromissions and took nearly twice as long to achieve

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7

Zhang, W., M. Yorek, C. R. Pierson, Y. Murakawa, A. Breidenbach, and A. A. F. Sima. "Human C-peptide Dose Dependently Prevents Early Neuropathy in the BB/Wor-rat." International Journal of Experimental Diabetes Research 2, no. 3 (2001): 187–93. http://dx.doi.org/10.1155/edr.2001.187.

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In order to explore the neuroprotective and crossspecies activities of.C-peptide on type 1 diabetic neuropathy, spontaneously diabetic BB/W-rats were given increasing doses of human recombinant Cpeptide (hrC-peptide). Diabetic rats received 10, 100, 500, or 1000 μg of hrC-peptide/kg body weight/ day from onset of diabetes. After 2 months of hrC-peptide administration, 100 μg and greater doses completely prevented the nerve conduction defect, which was associated with a significant but incomplete prevention of neuralNa+/K+-ATPase activity in diabetic rats with 500 μg or greater C-peptide replac

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8

Holmes, Amey, Lawrence J. Coppey, Eric P. Davidson, and Mark A. Yorek. "Rat Models of Diet-Induced Obesity and High Fat/Low Dose Streptozotocin Type 2 Diabetes: Effect of Reversal of High Fat Diet Compared to Treatment with Enalapril or Menhaden Oil on Glucose Utilization and Neuropathic Endpoints." Journal of Diabetes Research 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/307285.

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We examined whether reversal of high fat diet, stimulating weight loss, compared to two treatments previously shown to have beneficial effects, could improve glucose utilization and peripheral neuropathy in animal models of obesity and type 2 diabetes. Rats were fed a high fat diet and treated with a low dose of streptozotocin to create models of diet induced obesity or type 2 diabetes, respectively. Afterwards, rats were transferred to a normal diet or treated with enalapril or dietary enrichment with menhaden oil for 12 weeks. Obesity and to a greater extent type 2 diabetes were associated w

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9

Wang-Fischer, Yanlin, and Tina Garyantes. "Improving the Reliability and Utility of Streptozotocin-Induced Rat Diabetic Model." Journal of Diabetes Research 2018 (September 23, 2018): 1–14. http://dx.doi.org/10.1155/2018/8054073.

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The Streptozotocin- (STZ-) induced diabetic model is widely used; however, unexplained acute toxicity has given the model an unreliable reputation. To improve the reliability and utility of this model, we characterize the age dependence of STZ toxicity and introduce novel endpoints to assess diabetic complications and reveal possible mechanisms for diabetic development. Diabetes was induced by STZ injection into male, 6 to 23 weeks old, Sprague-Dawley rats. Their metabolic (glucose, lipids, and hormones), inflammatory (cytokines), histologic and behavioral endpoints were observed for 1.2 years

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10

Das, Smita, Jayanti Prava Behera, Y. Rojaramani, and Rashmi Ranjan Mohanty. "Effect of resveratrol on diabetic neuropathy in wistar albino rats." International Journal of Basic & Clinical Pharmacology 9, no. 1 (2019): 16. http://dx.doi.org/10.18203/2319-2003.ijbcp20195635.

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Background: Type 2 diabetes mellitus (DM) is a common chronic disease with increasing prevalence worldwide. Prolonged uncontrolled hyperglycemia, dyslipidemia are major risk factor for its complication like neuropathy. Since there is no definite treatment for diabetic neuropathy, this study aims to evaluate the effect of resveratrol on diabetic neuropathy in high fat diet with low dose streptozotocin induced type-2 DM model in wistar albino rats.Methods: First type 2 diabetic rat model was established. Wistar albino rats, fed with high-fat diet (HFD) rendered diabetic with streptozotocin, were

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11

Segan, Dr Rishu. "Rate Pressure Product In Type 2 Diabetic Cardiac Autonomic Neuropathy." Indian Journal of Applied Research 1, no. 11 (2011): 108–9. http://dx.doi.org/10.15373/2249555x/aug2012/35.

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12

SIMA, A. A. F. "CAN THE BB-RAT HELP TO UNRAVEL DIABETIC NEUROPATHY?" Neuropathology and Applied Neurobiology 11, no. 4 (1985): 253–64. http://dx.doi.org/10.1111/j.1365-2990.1985.tb00023.x.

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13

Ozaki, K., Koji Miura, Minoru Tsuchitani, and Isao Narama. "Peripheral neuropathy in the spontaneously diabetic WBN/Kob rat." Acta Neuropathologica 92, no. 6 (1996): 603–7. http://dx.doi.org/10.1007/s004010050567.

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14

Davidson, Eric P., Lawrence J. Coppey, Amey Holmes, et al. "Characterization of Diabetic Neuropathy in the Zucker Diabetic Sprague-Dawley Rat: A New Animal Model for Type 2 Diabetes." Journal of Diabetes Research 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/714273.

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Recently a new rat model for type 2 diabetes the Zucker diabetic Sprague-Dawley (ZDSD/Pco) was created. In this study we sought to characterize the development of diabetic neuropathy in ZDSD rats using age-matched Sprague-Dawley rats as a control. Rats were examined at 34 weeks of age 12 weeks after the onset of hyperglycemia in ZDSD rats. At this time ZDSD rats were severely insulin resistant with slowing of both motor and sensory nerve conduction velocities. ZDSD rats also had fatty livers, elevated serum free fatty acids, triglycerides, and cholesterol, and elevated sciatic nerve nitrotyros

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15

Cavusoglu, T., T. Karadeniz, E. Cagiltay, et al. "The Protective Effect of Losartan on Diabetic Neuropathy in a Diabetic Rat Model." Experimental and Clinical Endocrinology & Diabetes 123, no. 08 (2015): 479–84. http://dx.doi.org/10.1055/s-0035-1550019.

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16

Hall, Karen E., Jackie Liu, Anders A. F. Sima, and John W. Wiley. "Impaired Inhibitory G-Protein Function Contributes to Increased Calcium Currents in Rats With Diabetic Neuropathy." Journal of Neurophysiology 86, no. 2 (2001): 760–70. http://dx.doi.org/10.1152/jn.2001.86.2.760.

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There is a growing body of evidence that sensory neuropathy in diabetes is associated with abnormal calcium signaling in dorsal root ganglion (DRG) neurons. Enhanced influx of calcium via multiple high-threshold calcium currents is present in sensory neurons of several models of diabetes mellitus, including the spontaneously diabetic BioBred/Worchester (BB/W) rat and the chemical streptozotocin (STZ)-induced rat. We believe that abnormal calcium signaling in diabetes has pathologic significance as elevation of calcium influx and cytosolic calcium release has been implicated in other neurodegen

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17

Boyar, Handan, Belma Turan, and Feride Severcan. "FTIR Spectroscopic Investigation of Mineral Structure of Streptozotocin Induced Diabetic Rat Femur and Tibia." Spectroscopy 17, no. 2-3 (2003): 627–33. http://dx.doi.org/10.1155/2003/826545.

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Diabetes mellitus (DM) can be accepted as a heterogenous multi organ disorder that can affect various systems of the human body. Disorders include retinopathy, neuropathy, cardiomyopathy, musculoskeletal abnormalities such as diminished bone formation and bone healing retardation. Low bone mineral density is often mentioned as a complication for patients with insulin dependent diabetes mellitus (type I DM). Streptozotocin (STZ) induced diabetic rats are good models for investigation of the complications of insulin dependent diabetes. In the present study, the effects of STZ induced diabetes on

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18

Busik, Julia V., Maria Tikhonenko, Ashay Bhatwadekar, et al. "Diabetic retinopathy is associated with bone marrow neuropathy and a depressed peripheral clock." Journal of Experimental Medicine 206, no. 13 (2009): 2897–906. http://dx.doi.org/10.1084/jem.20090889.

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The present epidemic of diabetes is resulting in a worldwide increase in cardiovascular and microvascular complications including retinopathy. Current thinking has focused on local influences in the retina as being responsible for development of this diabetic complication. However, the contribution of circulating cells in maintenance, repair, and dysfunction of the vasculature is now becoming appreciated. Diabetic individuals have fewer endothelial progenitor cells (EPCs) in their circulation and these cells have diminished migratory potential, which contributes to their decreased reparative c

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19

Kihara, M., J. D. Schmelzer, and P. A. Low. "Effect of cilostazol on experimental diabetic neuropathy in the rat." Diabetologia 38, no. 8 (1995): 914–18. http://dx.doi.org/10.1007/bf00400579.

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20

Kihara, M., J. D. Schmelzer, and P. A. Low. "Effect of cilostazol on experimental diabetic neuropathy in the rat." Diabetologia 38, no. 8 (1995): 914–18. http://dx.doi.org/10.1007/s001250050371.

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21

Sima, Anders A. F., Wei-Xian Zhang, and Douglas A. Greene. "Diabetic and hypoglycemic neuropathy — a comparison in the BB rat." Diabetes Research and Clinical Practice 6, no. 4 (1989): 279–96. http://dx.doi.org/10.1016/0168-8227(89)90068-5.

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22

Coppey, Lawrence J., Amey Holmes, Eric P. Davidson, and Mark A. Yorek. "Partial Replacement with Menhaden Oil Improves Peripheral Neuropathy in High-Fat-Fed Low-Dose Streptozotocin Type 2 Diabetic Rat." Journal of Nutrition and Metabolism 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/950517.

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Aims. To determine the effect of partial replacement of a high-fat diet with menhaden oil on diabetic neuropathy in an animal model of type 2 diabetes.Materials and Methods. High-fat/low-dose streptozotocin diabetic rats were used to examine the influence of replacing 50% of the source of the high-fat diet (lard) with menhaden oil, a natural source of n-3 fatty acids, on diabetic neuropathy. Endpoints included analyses of glucose tolerance, fatty liver disease, serum and liver fatty acid composition, serum lipid and adiponectin levels, motor and sensory nerve conduction velocity, thermal sensi

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23

Mongold, J. J., G. H. Gros, A. Michel, J. H. McNeill, and J. J. Serrano. "Diabetes-induced rat tracheal segment supersensitivity to carbachol." Canadian Journal of Physiology and Pharmacology 66, no. 5 (1988): 660–62. http://dx.doi.org/10.1139/y88-103.

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Contractile responses to carbachol of tracheal segments isolated (i) from rats made diabetic 4 months prior by a single intravenous injection (50 mg/kg) of streptozotocin (group B), and (ii) from diabetic rats that had been treated during the same period with a daily dose (2–4 U/animal) of long-acting insulin (group C) were compared with the contractile responses of trachea isolated from age-matched control animals (group A). Tracheal segments from group B were significantly more responsive to carbachol than those from group A or C at low, but not at high carbachol concentrations. Carbachol pD

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Chen, Ji, Chao Li, Wenjie Liu, Bin Yan, Xiaoling Hu, and Fengrui Yang. "miRNA-155 silencing reduces sciatic nerve injury in diabetic peripheral neuropathy." Journal of Molecular Endocrinology 63, no. 3 (2019): 227–38. http://dx.doi.org/10.1530/jme-19-0067.

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Neuropathic pain represents one of the most common complications associated with diabetes mellitus (DM) that impacts quality of life. Accumulating studies have highlighted the involvement of miRNAs in DM. Thus, the current study aimed to investigate the roles of miR-155 in diabetic peripheral neuropathy (DPN). In vitro DPN models were established using rat Schwann cells (SCs) by treatment with 5.5 mM glucose. Gain- or loss-of-function studies were conducted to determine the effect of miR-155 on Nrf2, cellular function, reactive oxygen species and inflammation. Rat DNP models were established b

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Luheshi, G. N., and M. A. Zar. "Effect of streptozotocin diabetes on motor and inhibitory transmission in rat anococcygeus." Canadian Journal of Physiology and Pharmacology 70, no. 10 (1992): 1372–78. http://dx.doi.org/10.1139/y92-192.

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The effect of streptozotocin diabetes of 4-week duration on the adrenergic motor transmission and on the nonadrenergic, noncholinergic, inhibitory transmission in the rat anococcygeus was investigated by recording contractile and relaxant activity of isolated muscle preparations taken from diabetic and age-matched control animals. The neurogenic contractile responses to electrical field stimulation were significantly reduced in the preparations from diabetic rats. The inhibitory transmission remained unaffected in the diabetic rats. Concentration–response curves showed no change in sensitivity

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Hangping, Zheng, Han Ling, Ji Lijin, et al. "The Preventive Effect of IL-1beta Antagonist on Diabetic Peripheral Neuropathy." Endocrine, Metabolic & Immune Disorders - Drug Targets 20, no. 5 (2020): 753–59. http://dx.doi.org/10.2174/1871530319666191022114139.

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Objective: To investigate the relationship between Interleukin-1beta (IL-1beta) and diabetic peripheral neuropathy (DPN) using animal models. Materials: The rat model of diabetic neuropathy was induced by intraperitoneal injection of a single dose of streptozotocin (STZ) at 65mg/kg. Diabetic rats were randomly divided into two groups (10 each), one treated with 0.9% saline (DMS group) and the other with interleukin-1 receptor antagonist (IL-1RA) at 50mg/kg (DMI group) twice a day for 5 weeks. Ten normal rats matched for weight, age and sex served as normal controls (Con group) and were treated

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Liao, Chenlong, Min Yang, Pengfei Liu, Wenxiang Zhong, and Wenchuan Zhang. "Stable Rat Model of Mechanical Allodynia in Diabetic Peripheral Neuropathy: The Role of Nerve Compression." Journal of Reconstructive Microsurgery 34, no. 04 (2018): 264–69. http://dx.doi.org/10.1055/s-0037-1621723.

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Background Preclinical studies involving animal models are essential for understanding the underlying mechanisms of diabetic neuropathic pain. Methods Rats were divided into four groups: two controls and two experimental. Diabetes mellitus was induced by streptozotocin (STZ) injection in two experimental groups. The first group involved one sham operation. The second group involved one latex tube encircling the sciatic nerve. The vehicle-injection rats were used as two corresponding control groups: sham operation and encircled nerves. By the third week, STZ-injected rats with encircled nerves

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Andreasen, Laura J., Rikke K. Kirk, Christian Fledelius, Mark A. Yorek, Jens Lykkesfeldt, and Thorbjorn Akerstrom. "Insulin Treatment Attenuates Small Nerve Fiber Damage in Rat Model of Type 2 Diabetes." Journal of Diabetes Research 2020 (August 4, 2020): 1–13. http://dx.doi.org/10.1155/2020/9626398.

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Introduction. Current clinical guidelines for management of diabetic peripheral neuropathy (DPN) emphasize good glycemic control. However, this has limited effect on prevention of DPN in type 2 diabetic (T2D) patients. This study investigates the effect of insulin treatment on development of DPN in a rat model of T2D to assess the underlying causes leading to DPN. Methods. Twelve-week-old male Sprague-Dawley rats were allocated to a normal chow diet or a 45% kcal high-fat diet. After eight weeks, the high-fat fed animals received a mild dose of streptozotocin to induce hyperglycemia. Four week

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Thipkaew, Chonlathip, Jintanaporn Wattanathorn, and Supaporn Muchimapura. "Electrospun Nanofibers Loaded with Quercetin Promote the Recovery of Focal Entrapment Neuropathy in a Rat Model of Streptozotocin-Induced Diabetes." BioMed Research International 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/2017493.

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In this study, quercetin-loaded zein-based nanofibers were developed using electrospinning technique. The therapeutic effect of these quercetin-loaded nanofibers on neuropathy in streptozotocin- (STZ-) induced diabetes in rats was assessed. Diabetic condition was induced in male Wistar rats by STZ, after which a crush injury of the right sciatic nerve was performed to induce mononeuropathy. Functional recovery was assessed using walking track analysis, measurements of foot withdrawal reflex, nerve conduction velocity, and morphological analysis. The oxidative stress status and the ratio of pho

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Cui, Xiaopei, Hua Feng, Xia Xu, Haijun Li та Hongyu Zhang. "PGC-1αMediated Peripheral Nerve Protection of Tongxinluo in STZ-Induced Diabetic Rats". Evidence-Based Complementary and Alternative Medicine 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/1287909.

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Aim. To investigate the effect of Tongxinluo (Txl), a Chinese herbal compound, on diabetic peripheral neuropathy (DPN).Methods and Results. Diabetic rat model was established by peritoneal injection of streptozotocin (STZ). Txl ultrafine powder treatment for 16 weeks from the baseline significantly reversed the impairment of motor nerve conductive velocity (MNCV), mechanical hyperalgesia, and nerve structure. We further proved that Tongxinluo upregulates PGC-1αand its downstream factors including COX IV and SOD, which were involved in mitochondrial biogenesis.Conclusion.Our study indicates tha

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Rahman, MM, Z. Hassan, KB Biswas, NB Bhowmik, and L. Ali. "Plasma total homocysteine is not associated with peripheral neuropathy in a groups Bangladeshi type 2 diabetic subjects." Bangladesh Journal of Medical Science 11, no. 4 (2012): 335–42. http://dx.doi.org/10.3329/bjms.v11i4.12607.

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Aims: The present study was undertaken to explore the relationship of plasma homocysteine in the pathogenesis of neuropathy in diabetic patients.Subjects and Methods: Forty two type 2 diabetic patients [22 with neuropathy (DN group) and 20 without neuropathy (DNN group)], age range between 35-70 years had relatively controlled glycemia and duration of diabetes 7-15 years, were studied. Motor and sensory nerve conduction velocities and action potential amplitudes of peripheral nerves were determined by following standard protocol. HbA1c was estimated by modified HPLC (BIO-RAD Variant, USA). Ser

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Matsuka, Yoshizo, and Igor Spigelman. "Hyperosmolar Solutions Selectively Block Action Potentials in Rat Myelinated Sensory Fibers: Implications for Diabetic Neuropathy." Journal of Neurophysiology 91, no. 1 (2004): 48–56. http://dx.doi.org/10.1152/jn.00689.2003.

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Diabetic neuropathy is a common complication of diabetes mellitus patients. It is a wide range of abnormalities affecting proximal and distal peripheral sensory and motor nerves. Although plasma hyperosmolality is a common finding in diabetes mellitus, the effects of hyperosmolality on conduction of various sensory signal components have not been addressed in detail. Here we show that in rat dorsal root ganglion (DRG) preparations from normal rats, hyperosmolar solutions (360 mmol/kg, containing increased glucose, sucrose, NaCl, or mannitol) produce a selective block of signal propagation in m

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Mathias Akinlade, Olawale, Bamidele Victor Owoyele, and Ayodele Olufemi Soladoye. "Streptozotocin-induced type 1 and 2 diabetes in rodents: a model for studying diabetic cardiac autonomic neuropathy." African Health Sciences 21, no. 2 (2021): 719–27. http://dx.doi.org/10.4314/ahs.v21i2.30.

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Background: Several animal models are continually being developed to study diabetic complication. Several conflicting regimen for diabetes induction exist in the literature with varying dose strength and regimen for different study interest in diabetes. This study aims to show the effect of high dose streptozotocin (STZ) on the one hand compared with multiple low doses after high fat diet induction on diabetic cardiac autonomic neuropathy (DCAN). Methodology: Eighty-four Wistar rats were used to demonstrate DCAN induction using 2 approaches one for T1DM (STZ 50mg/kg) and the other for T2DM (HF

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Sima, A. A. F., A. C. Merry, D. E. Hall, M. B. Grant, F. T. Murray, and D. Guberski. "The BBZ/WORDR-rat: A model for Type II diabetic neuropathy." Experimental and Clinical Endocrinology & Diabetes 105, S 03 (2009): 63. http://dx.doi.org/10.1055/s-0029-1211884.

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Guo, C., A. Quobatari, Y. Shangguan, S. Hong, J. W. Wiley, and A. Quobatari. "Diabetic autonomic neuropathy: evidence for apoptosis in situ in the rat." Neurogastroenterology and Motility 16, no. 3 (2004): 335–45. http://dx.doi.org/10.1111/j.1365-2982.2004.00524.x.

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Johansen, N. J., R. Abela, and J. A. Brock. "Perivascular sympathetic neuropathy in the streptozotocin type I diabetic rat model." Autonomic Neuroscience 163, no. 1-2 (2011): 105. http://dx.doi.org/10.1016/j.autneu.2011.05.182.

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Tu, Yiji, Zenggan Chen, Junda Hu, et al. "Chronic Nerve Compression Accelerates the Progression of Diabetic Peripheral Neuropathy in a Rat Model: A Study of Gene Expression Profiling." Journal of Reconstructive Microsurgery 34, no. 07 (2018): 537–48. http://dx.doi.org/10.1055/s-0038-1642023.

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Objective This article investigates the role of chronic nerve compression in the progression of diabetic peripheral neuropathy (DPN) by gene expression profiling. Methods Chronic nerve compression was created in streptozotocin (STZ)-induced diabetic rats by wrapping a silicone tube around the sciatic nerve (SCN). Neurological deficits were evaluated using pain threshold test, motor nerve conduction velocity (MNCV), and histopathologic examination. Differentially expressed genes (DGEs) and metabolic processes associated with chronic nerve compression were analyzed. Results Significant changes i

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Sheng, Xuan, Jiayue Wang, Jingjing Guo, et al. "Effects of Baicalin on Diabetic Cardiac Autonomic Neuropathy Mediated by the P2Y12 Receptor in Rat Stellate Ganglia." Cellular Physiology and Biochemistry 46, no. 3 (2018): 986–98. http://dx.doi.org/10.1159/000488828.

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Background/Aims: Chronic diabetic hyperglycemia can damage various of organ systems and cause serious complications. Although diabetic cardiac autonomic neuropathy (DCAN) is the primary cause of death in diabetic patients, its pathogenesis remains to be fully elucidated. Baicalin is a flavonoid extracted from Scutellaria baicalensis root and has antibacterial, diuretic, anti-inflammatory, anti- metamorphotic, and antispasmodic effects. Our study explored the effects of baicalin on enhancing sympathoexcitatory response induced by DCAN via the P2Y12 receptor. Methods: A type 2 diabetes mellitus

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WALKER, DAVID, ANNE CARRINGTON, SUSAN A. CANNAN, et al. "Structural abnormalities do not explain the early functional abnormalities in the peripheral nerves of the streptozotocin diabetic rat." Journal of Anatomy 195, no. 3 (1999): 419–27. http://dx.doi.org/10.1017/s002187829900549x.

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The streptozotocin (STZ)-diabetic rat, the most commonly employed model of experimental diabetic neuropathy, is characterised by a reduction in nerve conduction velocity, pain threshold and blood flow. Whether or not structural abnormalities underlie these functional abnormalities is unclear. 10 adult male Sprague–Dawley STZ-diabetic rats (diabetes duration 27 d) and 10 age-matched (23 wk) control animals were studied. Motor nerve conduction velocity (m s−1) was significantly reduced in diabetic (41.31±0.8) compared with control (46.15±1.5) animals (P<0.001). The concentration of sciatic ne

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Ohta, Takeshi, Yoshiaki Katsuda, Katsuhiro Miyajima, et al. "Gender Differences in Metabolic Disorders and Related Diseases in Spontaneously Diabetic Torii-LeprfaRats." Journal of Diabetes Research 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/841957.

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The Spontaneously Diabetic ToriiLeprfa(SDT fatty) rat is a novel type 2 diabetic model wherein both male and female rats develop glucose and lipid abnormalities from a young age. In this study, we investigated gender differences in abnormalities and related complications in SDT fatty rats. Food intake was higher in males compared to female rats; however, body weight was not different between genders. Progression of diabetes, including increases in blood glucose and declines in blood insulin, was observed earlier in male rats than in females, and diabetic grade was more critical in male rats. B

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Yagihashi, S., and A. A. Sima. "Diabetic autonomic neuropathy in BB rat. Ultrastructural and morphometric changes in parasympathetic nerves." Diabetes 35, no. 7 (1986): 733–43. http://dx.doi.org/10.2337/diabetes.35.7.733.

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Wang, Qi, Zhuang-Li Guo, Ge-Le Aori, et al. "Danhong Injection Alleviates Mechanical Allodynia via Inhibiting ERK1/2 Activation and Elevates BDNF Level in Sciatic Nerve in Diabetic Rat." Evidence-Based Complementary and Alternative Medicine 2018 (2018): 1–7. http://dx.doi.org/10.1155/2018/5798453.

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Danhong injection (DHI) has been widely used in China for cardiocerebrovascular diseases treatments. And in this study, we demonstrated the therapeutic effect of DHI on experimental diabetic neuropathy for the first time. Methods. Streptozotocin- (STZ-) induced SD rats were used. In experiment 1, 4-week treatment with DHI or saline started 4 weeks after STZ injection; mechanical allodynia was measured before and every 2 weeks after STZ injection. In experiment 2, chronic intrathecal infusion of U0126 was conducted during the 8th week of diabetes. Phosphorylated and total ERK1/2 in spinal cord

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Stümpel, Frank, Tomas Kucera, and Kurt Jungermann. "Impaired stimulation of intestinal glucose absorption via hepatoenteral nerves in streptozotocin-diabetic rats." American Journal of Physiology-Gastrointestinal and Liver Physiology 277, no. 2 (1999): G285—G291. http://dx.doi.org/10.1152/ajpgi.1999.277.2.g285.

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In an ex situ organ perfusion system, that of the isolated nonrecirculating joint perfusion of rat small intestine and liver, insulin infused into the portal vein increased intestinal glucose absorption. This insulin action against the bloodstream can be blocked by TTX, indicating a propagation of the insulin signal via hepatoenteral nerves, which conforms with previous studies with atropine and carbachol. Insulin action could also be mimicked by dibutyryl cAMP (DBcAMP) acting directly on the absorptive enterocytes. Because autonomic neuropathy is a common late complication of diabetes mellitu

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Fischer, Kenneth J., Elizabeth A. Novak, Irina V. Smirnova, G. Kesava Reddy, and Lisa Stehno-Bittel. "EFFECTS OF DIABETES AND EXERCISE ON SOFT CONNECTIVE TISSUE PROPERTIES AT THE KNEE IN THE RAT." Journal of Musculoskeletal Research 12, no. 02 (2009): 95–104. http://dx.doi.org/10.1142/s0218957709002237.

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The primary diabetes-related health concerns are neuropathy and cardiovascular changes. Connective tissue changes can also affect quality of life by increasing ligament and joint capsule stiffness, impairing proprioception, limiting function, and leading to greater risk of falling. Our objectives were to evaluate effects of Type I diabetes and exercise on medial collateral ligament properties and overall knee-joint stiffness and stress relaxation. Thirty-four male Sprague–Dawley rats, approximately two months old, were divided into three groups—sedentary controls (n=10), sedentary diabetics (n

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Xie, Min, Meijian Wang, Wei Liu, et al. "Lipin1 Is Involved in the Pathogenesis of Diabetic Encephalopathy through the PKD/Limk/Cofilin Signaling Pathway." Oxidative Medicine and Cellular Longevity 2020 (October 16, 2020): 1–14. http://dx.doi.org/10.1155/2020/1723423.

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Diabetic encephalopathy is a type of central diabetic neuropathy resulting from diabetes mainly manifested as cognitive impairments. However, its underlying pathogenesis and effective treatment strategies remain unclear. In the present study, we investigated the effect of Lipin1, a phosphatidic acid phosphatase enzyme, on the pathogenesis of diabetic encephalopathy. We found that in vitro, Lipin1 exerts protective effects on high glucose-induced reductions of PC12 cell viability, while in vivo, Lipin1 is downregulated within the CA1 hippocampal region in a type I diabetes rat model. Increased

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Sima, A. A., W. X. Zhang, W. J. Tze, J. Tai, and V. Nathaniel. "Diabetic neuropathy in STZ-induced diabetic rat and effect of allogeneic islet cell transplantation. Morphometric analysis." Diabetes 37, no. 8 (1988): 1129–36. http://dx.doi.org/10.2337/diabetes.37.8.1129.

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Bachhav, Rishikesh, and Ravindranath Saudagar. "EFFECT OF ETHANOLIC FLOWER EXTRACT OF SPATHODEA CAMPANULATA ON STREPTOZOTOCIN INDUCED DIABETIC NEUROPATHY." International Journal of Pharmacy and Pharmaceutical Sciences 10, no. 5 (2018): 64. http://dx.doi.org/10.22159/ijpps.2018v10i5.21968.

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Objective: To evaluate the effect of ethanolic extract of the flower of Spathodea camapanulata (EFESC) on streptozotocin-induced diabetic neuropathy.Methods: Non-insulin dependent diabetes mellitus (NIDDM) was induced in overnight fasted adult wistar strain albino male rats weighing 160-200g by a single intraperitoneal injection (i. p) of streptozotocin (STZ-65 mg/kg). The rats were randomized into six groups, with six animals each, namely normal control (NC) (Treated with 1% carboxymethyl cellulose solution), diabetic control (DC) (65 mg/kg., i. p. STZ), test group treated at various doses of

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Bhatt, Niraj Mukundray, Suparna Barua, and Sarita Gupta. "Protective Effect of Enicostemma littorale Blume on Rat Model of Diabetic Neuropathy." American Journal of Infectious Diseases 5, no. 2 (2009): 106–12. http://dx.doi.org/10.3844/ajidsp.2009.106.112.

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Ostovar, Mohadeseh, Abolfazl Akbari, Mohammad Hossein Anbardar, et al. "Effects of Citrullus colocynthis L. in a rat model of diabetic neuropathy." Journal of Integrative Medicine 18, no. 1 (2020): 59–67. http://dx.doi.org/10.1016/j.joim.2019.12.002.

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Addicks, Klaus, Christian Boy, and Peter Rösen. "Sympathetic autonomic neuropathy in the heart of the spontaneous diabetic BB rat." Annals of Anatomy - Anatomischer Anzeiger 175, no. 3 (1993): 253–57. http://dx.doi.org/10.1016/s0940-9602(11)80012-9.

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