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Journal articles on the topic 'Diagnosis of pre-concepts'

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1

Padliyyah, Siti Hannah. "Integration of Self-diagnosis in Pascal Law Learning Using STEM Approach." Dinamika Jurnal Ilmiah Pendidikan Dasar 12, no. 2 (2020): 104. http://dx.doi.org/10.30595/dinamika.v12i2.6397.

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Indonesia is ranked 56th out of 65 participating countries in the Program for International Student Assessment (PISA) based on data 2015. According to PISA results, the average science score of Indonesian students is 403, where this number is categorized as low. This is because students are still in the process of understanding and have not yet fully recognized the location of their mistakes. Students can diagnose the location of their mistakes through self-diagnosis activities. Self-diagnosis activities require the active role of students during the learning process. One approach that can inc
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Poppe, Christopher. "Hopelessness in palliative care for people with motor neurone disease: Conceptual considerations." Nursing Ethics 27, no. 1 (2020): 316–20. http://dx.doi.org/10.1177/0969733019901225.

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The concepts of hope and its absence, hopelessness, are seen as crucial in palliative care for people with motor neurone disease. A primary measure in psychological research on hopelessness in people with motor neurone disease is the Beck Hopelessness Scale. This scale can be understood as being conceptually based on the philosophical standard account of hope, which understands hope as an intentional expectancy. This essay argues that this is a misconstruction of hopelessness in palliative care. Rather, pre-intentional hope is essential for palliative care of people with motor neurone disease.
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Rogers, Kirrily, Honor Coleman, Amy Brodtmann, David Darby, and Vicki Anderson. "Family members’ experience of the pre-diagnostic phase of dementia: a synthesis of qualitative evidence." International Psychogeriatrics 29, no. 9 (2017): 1425–37. http://dx.doi.org/10.1017/s1041610217000862.

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ABSTRACTBackground:Most research on family members’ experience of dementia has focused on the time after diagnosis. Yet, once people reach clinical attention, families have already been living with the changes for some time. These pre-diagnosis experiences can influence later caregiving. We aimed to synthesize qualitative research exploring family members’ experiences of the pre-diagnostic phase of dementia to inform clinical practice.Methods:We conducted a thematic synthesis of 11 studies that met our inclusion criteria following a comprehensive literature search.Results:An overarching theme,
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Ungar, Andrea, Elena Lotti, and Lorella Lambertucci. "Hypertension in pregnancy." Clinical Management Issues 1, no. 1 (2007): 13–20. http://dx.doi.org/10.7175/cmi.v1i1.615.

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Hypertension is the most common medical problem encountered during pregnancy, complicating 2-3% of pregnancies. Hypertensive disorders during pregnancy are classified into 4 categories: chronic hypertension, pre-eclampsia/eclampsia, pre-eclampsia superimposed on chronic hypertension, and gestational hypertension. A relative paucity of investigative data, as well as the frequent difficulty in making an etiological diagnosis, may lead to problems in its management. This case report analyses current concepts regarding the hypertensive disorders of gestation, focusing on chronic hypertension. Chro
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Hodges, Victoria, Chloe Hobbis, Helen Twohig, and Caroline Mitchell. "Exploring the experience of a ‘diagnosis’ of pre-diabetes and factors influencing uptake of a lifestyle intervention programme in areas of socio-economic deprivation." British Journal of General Practice 68, suppl 1 (2018): bjgp18X697325. http://dx.doi.org/10.3399/bjgp18x697325.

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BackgroundPeople living in socio-economically deprived areas are at higher risk of developing diabetes and have worse health outcomes when they do. A Diabetes Prevention Programme (DPP) is being rolled out across England with eligibility linked to a HbA1c screening test to ‘diagnose’ pre-diabetes (42–47 mmol/mol). The DPP is a lifestyle intervention offering a 9-month individualised programme aiming to reduce progression to diabetes, through optimization of diet and physical activity to achieve weight loss. Previous studies suggest that patients from lower socioeconomic groups are less likely
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Bernhardson, Britt-Marie, Carol Tishelman, Birgit H. Rasmussen, et al. "Sensations, symptoms, and then what? Early bodily experiences prior to diagnosis of lung cancer." PLOS ONE 16, no. 3 (2021): e0249114. http://dx.doi.org/10.1371/journal.pone.0249114.

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Lung cancer (LC) generally lacks unique core symptoms or signs. However, there are a multitude of bodily sensations that are often non-specific, not easily understood, and many times initially not recognized as indicative of LC by the affected person, which often leads to late diagnosis. In this international qualitative study, we inductively analyzed retrospective accounts of 61 people diagnosed with LC in Denmark, England and Sweden. Using the bodily sensations they most commonly spoke about (tiredness, breathlessness, pain, and cough), we constructed four sensation-based cases to understand
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N Augustine, Tanya. "The aegis: platelets as biomarkers of tumor progression." Biomarkers in Medicine 14, no. 7 (2020): 573–85. http://dx.doi.org/10.2217/bmm-2019-0514.

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There is increasing awareness that platelets play a significant role in creating a hypercoagulable environment that mediates tumor progression, beyond their classical hemostatic function. Platelets have heterogenic responses to agonists, and differential release and uptake of bioactive molecules may be manipulated via reciprocal cross-talk with cells of the tumor microenvironment. Platelets thus promote tumor progression by enhancing tumor growth, promoting the development of tumor-associated vasculature and encouraging invasion. In the metastatic process, platelets form the shield that protec
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Veleva, Victoria. "A PROJECTIVE METHODOLOGY FOR THE DIAGNOSIS OF CHILDREN'S CONCEPTS ABOUT THE INFLUENCE OF THE ANTHROPOGENIC FACTOR ON THE STATE OF THE ENVIRONMENT (AS THE HABITAT OF ALL LIVING CREATURES)." Knowledge International Journal 34, no. 6 (2019): 1727–31. http://dx.doi.org/10.35120/kij34061727v.

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In today's dynamic world, in the course of the intensive technology development, adolescent's interest is being shifted to the audio-visual technologies and the media, the values and morals are depreciated, anthropocentrism, expressed in the message "Man - the master of nature," is being enforced.The basic paradigm of our consumer-oriented daily life is creating ever more complex environmental problems, especially when interacting with the surrounding world. This determines not only the acquisition but also the subsequent deepening of the environmental competence of adolescents starting from p
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Roderburg, Christoph, Alexander Wree, Münevver Demir, Moritz Schmelzle, and Frank Tacke. "The role of the innate immune system in the development and treatment of hepatocellular carcinoma." Hepatic Oncology 7, no. 1 (2020): HEP17. http://dx.doi.org/10.2217/hep-2019-0007.

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Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Most patients present with advanced or metastatic HCC at diagnosis and face a dismal prognosis. Tyrosine kinases are the gold standard treatment for this disease but yield limited survival benefits. Immune checkpoint inhibitors that augment adaptive immunity have been tested in HCC. Complex interactions between tumor cells, lymphocytes and the tumor environment determine the efficacy of such immunotherapies. Innate immune mechanisms – known drivers of liver disease progression in pre-HCC conditions such as fibrosis or cirr
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Kilian, Adam, Laura A. Upton, and John N. Sheagren. "Reorganizing the History of Present Illness to Improve Verbal Case Presenting and Clinical Diagnostic Reasoning Skills of Medical Students: The All-Inclusive History of Present Illness." Journal of Medical Education and Curricular Development 7 (January 2020): 238212052092899. http://dx.doi.org/10.1177/2382120520928996.

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The Institute of Medicine states that most diagnostic errors are caused by flaws in clinician diagnostic thinking. Accurately inferring the correct diagnosis from the patient history is the best way to improve diagnostic accuracy and efficiency. Such an improvement is contingent upon training early phase medical learners how to organize data from a patient history to arrive at the most likely diagnosis of the patient’s chief health concern (CC). We describe how organizing the traditional history of present illness into what our trainees have come to call the “ All-Inclusive History of Present
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Banerjee, Shubhendu, Sumit Kumar Singh, Avishek Chakraborty, Atanu Das, and Rajib Bag. "Melanoma Diagnosis Using Deep Learning and Fuzzy Logic." Diagnostics 10, no. 8 (2020): 577. http://dx.doi.org/10.3390/diagnostics10080577.

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Melanoma or malignant melanoma is a type of skin cancer that develops when melanocyte cells, damaged by excessive exposure to harmful UV radiations, start to grow out of control. Though less common than some other kinds of skin cancers, it is more dangerous because it rapidly metastasizes if not diagnosed and treated at an early stage. The distinction between benign and melanocytic lesions could at times be perplexing, but the manifestations of the disease could fairly be distinguished by a skilled study of its histopathological and clinical features. In recent years, deep convolutional neural
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Lasch, K. E., K. A. Jernigan, J. A. Scott, and E. Piault-Louis. "Interviews with cancer fatigue patients." Journal of Clinical Oncology 27, no. 15_suppl (2009): e17577-e17577. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e17577.

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e17577 Background: Approximately 90% of patients diagnosed with cancer experience fatigue associated with the effects of treatment and/or cancer itself. Despite its high prevalence and negative impact on patients’ lives, there is no consensus on a clinical definition of cancer-related fatigue (CF). Extant qualitative research has methodological limitations, small sample sizes, and varying results regarding CF. A multi-disciplinary research consortium is developing a conceptual model of CF based on 120 qualitative interviews with cancer patients varying by cancer type and stage. Exploratory int
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Thomas, Elizabeth T., Paul Glasziou, and Claudia C. Dobler. "Use of the terms “overdiagnosis” and “misdiagnosis” in the COPD literature: a rapid review." Breathe 15, no. 1 (2019): e8-e19. http://dx.doi.org/10.1183/20734735.0354-2018.

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Challenges in the diagnostic process of chronic obstructive pulmonary disease (COPD) can result in diagnostic misclassifications, including overdiagnosis. The term “overdiagnosis” in general has been associated with variable definitions. In connection with efforts to reduce low-value care, “overdiagnosis” has been defined as a true positive diagnosis of a condition that is not associated with any harm in the diagnosed person. It is, however, unclear how the term “overdiagnosis” is used in the COPD literature. We conducted a rapid review of the literature to explore how the terms “overdiagnosis
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Cortes Rivera, Mateo, Claudio Mastronardi, Claudia Silva-Aldana, Mauricio Arcos-Burgos, and Brett Lidbury. "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Comprehensive Review." Diagnostics 9, no. 3 (2019): 91. http://dx.doi.org/10.3390/diagnostics9030091.

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Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic disease of unknown aetiology that is recognized by the World Health Organization (WHO) and the United States Center for Disease Control and Prevention (US CDC) as a disorder of the brain. The disease predominantly affects adults, with a peak age of onset of between 20 and 45 years with a female to male ratio of 3:1. Although the clinical features of the disease have been well established within diagnostic criteria, the diagnosis of ME/CFS is still of exclusion, meaning that other medical conditions must be ru
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Sun, Angela C., Eric R. Kessell, Janice Y. Tsoh, Joanne Chan, and Joyce Chang. "Can Preschoolers be Health Messengers to Promote Breast Health among Chinese Americans?" Californian Journal of Health Promotion 11, no. 3 (2013): 74–79. http://dx.doi.org/10.32398/cjhp.v11i3.1543.

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Women’s limited knowledge about breast cancer screening (BCS), combined with differences in Eastern and Western disease prevention concepts, may contribute to late-stage breast cancer diagnosis among minorities. Children can be conduits of knowledge transfer to adults. This pilot study tested the use of a culturally-tailored theatrical preschool performance in increasing Chinese American women’s knowledge of BCS guidelines. Chinese preschool children relayed BCS guidelines through a culturally-tailored theatrical performance. Data were collected from 177 Chinese American women (84% foreign-bor
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Fawkes, Jonathan. "An introduction to colonic polypectomy." Gastrointestinal Nursing 17, Sup8 (2019): S22—S27. http://dx.doi.org/10.12968/gasn.2019.17.sup8.s22.

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Background: Colorectal cancer is the fourth most common cancer in the UK. The vast majority of colorectal cancers develop from polyps. Polypectomy is an endoscopic therapy that interrupts the sequence by which a polyp develops into cancer. Methods: A review was conducted of the published literature and clinical guidelines relevant to colonic polypectomy, with an aim to introduce basic concepts of colorectal polyp assessment and management and to describe potential complications of polypectomy. Findings: Through optical lesion assessment, it is possible to identify polyps with malignant potenti
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Ezzat, Ahmed Aziz, Jiong Tang, and Yu Ding. "A model-based calibration approach for structural fault diagnosis using piezoelectric impedance measurements and a finite element model." Structural Health Monitoring 19, no. 6 (2020): 1839–55. http://dx.doi.org/10.1177/1475921719901168.

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The electromechanical coupling property of piezoelectric transducers gives rise to a promising class of structural fault diagnosis methods often referred to collectively as impedance-based approaches. One active line of research in the related literature is the development of data-driven methods that can leverage the available experimental impedance measurements to accurately pinpoint the location and severity of structural faults. In this article, we offer a new perspective to the problem by casting the impedance-based fault diagnosis into a statistical calibration formulation, which has gain
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Sutrisno, Asep Dedy, Achmad Samsudin, Winny Liliawati, Ida Kaniawati, and Endi Suhendi. "MODEL PEMBELAJARAN TWO STAY TWO STRAY (TSTS) DAN PEMAHAMAN SISWA TENTANG KONSEP MOMENTUM DAN IMPULS." Jurnal Pengajaran Matematika dan Ilmu Pengetahuan Alam 20, no. 1 (2015): 38. http://dx.doi.org/10.18269/jpmipa.v20i1.560.

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Experimental research about Two Stay Two Stray (TSTS) learning model has been conducted in one of senior high school in Bandung. This research aimed to analyze students’ understanding of momentum and impulse concepts by using TSTS learning model. Students’ conception were identified by multiple choice-diagnostics test using Certainty of Response Index (CRI) scale. Research method was pre-experimental design with one group pretest posttest design involving 37 students as research subjects. Results showed that profile of students’ understanding of momentum and impulse concepts were increased fro
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Camacho, Cleber P., Ana O. Hoff, Susan C. Lindsey, et al. "Early diagnosis of multiple endocrine neoplasia type 2B: a challenge for physicians." Arquivos Brasileiros de Endocrinologia & Metabologia 52, no. 8 (2008): 1393–98. http://dx.doi.org/10.1590/s0004-27302008000800031.

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BACKGROUND: The hereditary form of medullary thyroid carcinoma may occur isolated as a familial medullary thyroid carcinoma (FMTC) or as part of Multiple Endocrine Neoplasia 2A (MEN2A) and 2B (MEN2B). MEN2B is a rare syndrome, its phenotype may usually, but not always, be noted by the physician. In the infant none of the MEN2B characteristics are present, except by early gastrointestinal dysfunction caused by intestinal neuromas. When available, genetic analysis confirms the diagnosis and guides pre-operative evaluation and extent of surgery. Here we report four cases of MEN2B in which the lat
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Brown, Mallory McClester, Karen Halpert, Maureen Dale, Margaret Helton, and Gregg Warshaw. "Advanced Geriatrics Evaluation Skills." Family Medicine 52, no. 3 (2020): 206–8. http://dx.doi.org/10.22454/fammed.2020.139945.

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Background and Objectives: Older adults are the fastest growing subset of the population and residency training in the basic concepts of care to the older adult is limited. We created a 1-day interactive training program, Advanced Geriatric Evaluation Skills (AGES), to upskill first-year primary care residents in the care of older adults. Methods: An interprofessional faculty team developed and taught the IRB-approved course to a convenience sample of family medicine and internal medicine interns in 2017, 2018, and 2019. Topics addressed common geriatric presentations seen in the outpatient se
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Vasanthakumar, E. Umamaheswari, and Francis Bond. "A Semantic Multi-Field Clinical Search for Patient Medical Records." Cybernetics and Information Technologies 18, no. 1 (2018): 171–82. http://dx.doi.org/10.2478/cait-2018-0014.

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Abstract A semantic-based search engine for clinical data would be a substantial aid for hospitals to provide support for clinical practitioners. Since electronic medical records of patients contain a variety of information, there is a need to extract meaningful patterns from the Patient Medical Records (PMR). The proposed work matches patients to relevant clinical practice guidelines (CPGs) by matching their medical records with the CPGs. However in both PMR and CPG, the information pertaining to symptoms, diseases, diagnosis procedures and medicines is not structured and there is a need to p
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Koval, I. "Medical and psychological paradigm supervision somatic patients with comorbid mental disorders." Fundamental and applied researches in practice of leading scientific schools 27, no. 3 (2018): 46–56. http://dx.doi.org/10.33531/farplss.2018.3.06.

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The thesis is devoted to the research of medical and psychological paradigm Supervision of patients. Studies performed on clinical material of patients with a wide range of somatic disorders. This reveals the conceptual foundations of medical activities as a complex medical and psycho-pedagogical process, which not only improves the efficiency of the professional activities of doctors, but also the formation of individual image of the world of patients achieving this level of personal development where disease and related restrictions do not interfere with their self-development based on the e
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Saraste, Antti, Emanuele Barbato, Davide Capodanno, et al. "Imaging in ESC clinical guidelines: chronic coronary syndromes." European Heart Journal - Cardiovascular Imaging 20, no. 11 (2019): 1187–97. http://dx.doi.org/10.1093/ehjci/jez219.

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Abstract The European Society of Cardiology (ESC) has recently published new guidelines on the diagnosis and management of chronic coronary syndromes (CCS). The 2019 guideline identified six common clinical scenarios of CCS defined by the different evolutionary phases of coronary artery disease (CAD), excluding the situations in which an acute coronary event, often with coronary thrombus formation, dominates the clinical presentation. This review aims at providing a summary of novel or revised concepts in the guidelines together with the recent data underlying the major changes on the use of c
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Nemani, Abhishek K., William D. Grant, and Léon-Paul Noël. "Education and Training of Referring Physicians Decreases At-Home Call Demand." Journal of Graduate Medical Education 5, no. 1 (2013): 138–41. http://dx.doi.org/10.4300/jgme-d-11-00317.1.

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Abstract Background Excessive, sometimes unnecessary consultation challenges the ophthalmology resident's ability to obtain adequate rest and personal time while taking at-home calls. Basic training of nonophthalmologists in assessing and treating common ophthalmic emergencies offers a potential solution to this problem by providing primary caregivers the knowledge base, tools, and confidence to manage them independently. Objective We measured ophthalmic consultation requests at a large teaching institution and the impact of an educational intervention on the number and type of requests. Metho
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Oliveira, M., J. Rebelo, A. S. Costa, and C. Santos. "A case of acute and transient psychosis–What to expect?" European Psychiatry 33, S1 (2016): S364—S365. http://dx.doi.org/10.1016/j.eurpsy.2016.01.1306.

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IntroductionThe Tenth Revision of the International Classification of Diseases (ICD-10) introduced the category of Acute and transient psychotic disorders (ATPD), that assimilate clinical concepts such as the French Bouffée Délirante, Kleist and Leonhard's cycloid psychosis, and the scandinavian reactive psychosis.Methods and aimsThe authors present a clinical case of ATPD and a literature review based on PubMed/MEDLINE, using the keywords: “acute and transient psychotic disorder”, “prognosis” and “diagnostic stability”, aiming to discuss the main challenges regarding the diagnosis, treatment
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França-Neto, José de Barros, and Francisco Carlos Krzyzanowski. "Tetrazolium: an important test for physiological seed quality evaluation." Journal of Seed Science 41, no. 3 (2019): 359–66. http://dx.doi.org/10.1590/2317-1545v41n3223104.

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Abstract: The production of high quality seeds is linked to a good quality control system. In this system, the tetrazolium test plays an important role in the evaluation of the seed physiological quality, not only due to its relative quickness, but also because of the amount of information that the test presents, such as the indexes of viability and vigor, in addition to providing the diagnosis of possible seed quality problems, such as mechanical damage, insect damage, pre-harvest weathering and deterioration during storage. The development of the test had its beginnings at the end of the 19t
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Späth, Martin, Svetlana Korovkin, Christiane Antke, Martin Anlauf, and Holger S. Willenberg. "Aldosterone- and cortisol-co-secreting adrenal tumors: the lost subtype of primary aldosteronism." European Journal of Endocrinology 164, no. 4 (2011): 447–55. http://dx.doi.org/10.1530/eje-10-1070.

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Current guidelines suggest proving angiotensin-independent aldosterone secretion in patients with primary aldosteronism (PA). It is further recommended to demonstrate unilateral disease because of its consequence for therapy. A general screening for excess secretion of other hormones is not recommended. However, clinically relevant autonomous aldosterone production rarely originates in adrenal tumors, compromised of zona glomerulosa cells only. This article reviews published data on aldosterone- and cortisol-co-secreting tumors and shows that pre-operative diagnosis of such a lesion is benefic
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Johar, Sukhmeen Kaur, Deepali L. Jaybhaye, Shruti Chandra, and Prashant S. Mishra. "Evaluation of knowledge, attitude and practices of postgraduate medical students towards clinical research in a tertiary care teaching hospital." International Journal of Basic & Clinical Pharmacology 10, no. 7 (2021): 800. http://dx.doi.org/10.18203/2319-2003.ijbcp20212376.

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Background: Clinical research is a component of medical and health research that facilitates valuable knowledge regarding diagnosis, prevention as well as treatment of a disease. Nowadays, the practise of medicine is evidence-based and combining medical education with clinical research provides a channel for translating scientifically advanced knowledge into better public health. The aim of the study was to assess knowledge (K), attitude (A), and practices (P) about clinical research among post graduate medical students.Methods: After obtaining institutional ethics committee approval, a cross-
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Meldo, A. A., L. V. Utkin та T. N. Trofimova. "Artificial intelligence in medicine: current state and main directions of development of the intellectual diagnostics". Diagnostic radiology and radiotherapy 11, № 1 (2020): 9–17. http://dx.doi.org/10.22328/2079-5343-2020-11-1-9-17.

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The main difference between artificial intelligence (AI) systems and simple automated algorithms is the ability to learn, synthesize and conclude. The AI system is trained on a set of examples, including pictures, characteristics of patients with a certain disease, then it allows to generalize a lot of such examples and get some general functional dependence, which brings in line the patient data and a certain diagnosis. The system can be named intelligent if this synthetizing ability is realized. Although the AI systems are now becoming more understood and accepted by doctors, a deeper unders
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Ladenstein, Pötschger, Valteau-Couanet, et al. "Investigation of the Role of Dinutuximab Beta-Based Immunotherapy in the SIOPEN High-Risk Neuroblastoma 1 Trial (HR-NBL1)." Cancers 12, no. 2 (2020): 309. http://dx.doi.org/10.3390/cancers12020309.

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To explore the effects of immunotherapy in the International Society of Paediatric Oncology Europe Neuroblastoma Group SIOPEN high-risk neuroblastoma 1 trial (HR-NBL1 trial), two cohorts were studied: one prior to and one after the introduction of dinutuximab beta. All patients received standard induction and high-dose therapy (HDT) with autologous stem cell rescue (ASCR); the local control comprised surgery and radiotherapy to the primary tumour site, followed by isotretinoin. A landmark timepoint of 109 days, resulting from the median time between ASCR and initiation of immunotherapy, was us
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Verna, Roberto, Walter Alallon, Masami Murakami, et al. "Analytical Performance of COVID-19 Detection Methods (RT-PCR): Scientific and Societal Concerns." Life 11, no. 7 (2021): 660. http://dx.doi.org/10.3390/life11070660.

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Background. Health and social management of the SARS-CoV-2 epidemic, responsible for the COVID-19 disease, requires both screening tools and diagnostic procedures. Reliable screening tests aim at identifying (truely) infectious individuals that can spread the viral infection and therefore are essential for tracing and harnessing the epidemic diffusion. Instead, diagnostic tests should supplement clinical and radiological findings, thus helping in establishing the diagnosis. Several analytical assays, mostly using RT-PCR-based technologies, have become commercially available for healthcare work
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Hess, G., T. Flohr, N. Frickhofen, et al. "Efficacy of Rituximab Combined in Salvage- and High Dose-Therapy (HDT) for Patients with Relapsed NHL; Interim Analysis of a Multicenter Phase II Study." Blood 104, no. 11 (2004): 1325. http://dx.doi.org/10.1182/blood.v104.11.1325.1325.

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Abstract The introduction of Rituximab (R) in the treatment of B-NHL resulted in improvement in first line therapies for indolent (ind.) and aggressive (agg.) B-NHL. However, the value of R in intensive chemotherapy relapse strategies has not definitely been demonstrated. In a phase I/II clinical trial we have demonstrated safety of R as an in vivo purging agens in salvage and high dose therapy for relapsed/refractory B-NHL. This led, with promising response rates, to the initiation of a multicenter phase II trial to further prove therapeutic efficacy. Inclusion criteria were: Pt < 65 years
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Smaga, I. S. "Diagnostic problems of elementary soil processes and profile-differentiated soils of the Precarpathian region." Fundamental and Applied Soil Science 17, no. 1-2 (2016): 40–48. http://dx.doi.org/10.15421/041604.

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Present condition, scientific concepts and ways of further development of diagnosis problem of elementary soil processes and genetic nature profiled-differentiated gleyed soils of the Pre-Carpathian region, known as brownish-podzolic, brownsoil-podzolic and sod-podzolic, based on stable indicators of soil properties are studied. Eluvial-illuvial differentiation nature of the soil profile of the studied soils is founded. The aim of research was to develop criteria for the diagnosis of elementary soil processes and genetic nature profiled-differentiated soil deposits of Ciscarpathia and discover
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Ritchie, Karen, and Craig W. Ritchie. "Mild cognitive impairment (MCI) twenty years on." International Psychogeriatrics 24, no. 1 (2011): 1–5. http://dx.doi.org/10.1017/s1041610211002067.

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Cognitive decline has commonly been considered an inevitable result of brain aging and has been of clinical interest principally because of related difficulties with everyday functioning. Since the 1990s the “normality” of age-related cognitive decline has been called into question, being commonly attributed to a number of underlying disorders. Numerous concepts have been proposed which link subclinical cognitive change to pathological states (mild cognitive disorder, mild neurocognitive disorder, mild cognitive impairment). Of these, mild cognitive impairment (MCI) has become the most popular
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Saborowski, Anna, Ulrich Lehmann, and Arndt Vogel. "FGFR inhibitors in cholangiocarcinoma: what’s now and what’s next?" Therapeutic Advances in Medical Oncology 12 (January 2020): 175883592095329. http://dx.doi.org/10.1177/1758835920953293.

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Patients with intrahepatic cholangiocarcinoma (iCCA) face a highly dismal prognosis, due to late stage diagnosis, the relative chemoresistance of the disease, and an overall limited portfolio of established therapeutic concepts. In recent years, a number of next generation sequencing studies have provided detailed information on the molecular landscape of biliary malignancies, and have laid the groundwork for the evaluation of novel, targeted therapeutic opportunities. Although nearly 40% of patients harbor genetic alterations for which targeted options exist, rapid translation into clinical t
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Iyer, Shwetha, Erin Goss, Casey Browder, Gerald Paccione, and Julia Arnsten. "Development and evaluation of a clinical reasoning curriculum as part of an Internal Medicine Residency Program." Diagnosis 6, no. 2 (2019): 115–19. http://dx.doi.org/10.1515/dx-2018-0093.

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Abstract Background Errors in medicine are common and often tied to diagnosis. Educating physicians about the science of cognitive decision-making, especially during medical school and residency when trainees are still forming clinical habits, may enhance awareness of individual cognitive biases and has the potential to reduce diagnostic errors and improve patient safety. Methods The authors aimed to develop, implement and evaluate a clinical reasoning curriculum for Internal Medicine residents. The authors developed and delivered a clinical reasoning curriculum to 47 PGY2 residents in an Inte
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Kerkhofs, T. M. A., M. H. T. Ettaieb, I. G. C. Hermsen, and H. R. Haak. "Developing treatment for adrenocortical carcinoma." Endocrine-Related Cancer 22, no. 6 (2015): R325—R338. http://dx.doi.org/10.1530/erc-15-0318.

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Cancer of the adrenal cortex (ACC) is a rare endocrine malignancy with limited treatment options. Patients typically present with autonomous hormonal overproduction and/or a large abdominal mass. Hormonal assays and medical imaging can be diagnostic, but urinary steroid profiling might be a more sensitive technique to assess malignancy in adrenal tumours. The stage of the disease at diagnosis is the most important prognostic factor. The current staging system needs refinement, especially to separate aggressive from indolent disease in stage IV patients and to select patients who need adjuvant
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Alekhin, A. N., and A. Grekova. "Peculiarities of Thinking Formation in the Digital Environment." Клиническая и специальная психология 8, no. 1 (2019): 162–76. http://dx.doi.org/10.17759/cpse.2019080110.

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The purpose of the research is to identify the features of young men's thinking, whose mental development carried out in conditions of life virtualization (in a network society). Material and methods. The study involved 319 mentally healthy respondents who study in the universities of St. Petersburg at the specialties associated with computer technology. The control group consists of the 45 respondents from 38 to 50 years. The choice of the control group is related to the fact that the thinking of people of this age category was formed in the pre-digital era. The research program includes clas
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Nickel, Brooke, Caitlin Semsarian, Ray Moynihan, et al. "Public perceptions of changing the terminology for low-risk thyroid cancer: a qualitative focus group study." BMJ Open 9, no. 2 (2019): e025820. http://dx.doi.org/10.1136/bmjopen-2018-025820.

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ObjectivesTo investigate public perceptions of overdiagnosis and overtreatment in low-risk thyroid cancer and explore opinions regarding the proposed strategy to change the terminology of low-risk cancers.DesignQualitative study using focus groups that included a guided group discussion and presentation explaining thyroid cancer, overdiagnosis and overtreatment, and proposed communication strategies. Transcripts were analysed thematically.SettingSydney, Australia.ParticipantsForty-seven men and women of various ages from a range of socioeconomic backgrounds with no personal history of thyroid
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Saville-Smith, Richard. "Introducing ‘Disruption’ to Acute Religious Experiences: An Interdisciplinary approach to a multidisciplinary problem." Journal of the British Association for the Study of Religion (JBASR) 18 (February 16, 2017): 25. http://dx.doi.org/10.18792/jbasr.v18i1.7.

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Psychiatry and Religious Studies have common interests in extreme and extraordinary states when articulated in the languages of religions. For Religious Studies the problems with the category of religious experience are philosophical and profound; whilst the resurgence of interest in religion by psychiatrists (three meta-analyses in the past five years) has not repaired the damaging legacy of reductionist interpretations.
 In this paper I adopt an interdisciplinary approach to the religious experience discourse. From psychiatry I apply the new idea of Disruption, which makes its first app
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Herold, Sylvia, Matthias Kuhn, Uwe Platzbecker, et al. "A Unique Case of a Donor Cell Acute Myeloid Leukemia Reveals Complex Kinetics of Mutations and Evolution of the Disease." Blood 120, no. 21 (2012): 886. http://dx.doi.org/10.1182/blood.v120.21.886.886.

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Abstract Abstract 886 The diagnosis acute myeloid leukemia (AML) describes a heterogeneous group of myeloid stem cell disorders. Based on current concepts of disease development, the combination of at least two mutations is necessary for transformation, typically affecting transcription factors (e.g. RUNX1) blocking normal differentiation and growth promoting genes, e.g. receptor tyrosine kinases like FLT3. This model has been challenged by more recent results of genome-wide mutational analysis, which revealed a typical load of 8–12 mutations affecting several additional pathways, e.g. epigene
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A.A., Tkachuk, Kolpakov V.V, Tomilova E.A., and Bespalova T.V. "INDIVIDUAL-TYPOLOGICAL APPROACH TO THE ASSESSMENT OF MOTOR ACTIVITY AND FUNCTIONAL STATE OF SENIOR PRESCHOOL AND JUNIOR SCHOOL CHILDREN." “Educational bulletin “Consciousness” 22, no. 9 (2020): 19–27. http://dx.doi.org/10.26787/nydha-2686-6846-2020-22-9-19-27.

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Physical activity is of particular importance in the early stages of ontogenesis during the development and formation of the child's body. At the same time, recognizing the variability of motor activity in children of a healthy population, its assessment in the understanding of the norm is presented as an average indicator of the daily number of locomotions for a certain age and gender group, which does not allow us to fully characterize the individual typological features of this function. In this regard, the use of signal parametric scales is very controversial and new approaches to solving
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Yusuf, Erlangga, Leonard Seghers, Rogier A. S. Hoek, Johannes P. C. van den Akker, Lonneke G. M. Bode, and Bart J. A. Rijnders. "Aspergillus in Critically Ill COVID-19 Patients: A Scoping Review." Journal of Clinical Medicine 10, no. 11 (2021): 2469. http://dx.doi.org/10.3390/jcm10112469.

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Several reports have been published on Aspergillus findings in COVID-19 patients leading to a proposition of new disease entity COVID-19-associated pulmonary aspergillosis. This scoping review is designed at clarifying the concepts on how the findings of Aspergillus spp. in COVID-19 patients were interpreted. We searched Medline to identify the studies on Aspergillus spp. findings in COVID-19 patients. Included were observational studies containing the following information: explicit mention of the total number of the study population, study period, reason for obtaining respiratory samples, ca
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Hunter, Theresa, April Naegeli, Laure Delbecque, Tamara Al-Zubeidi, Hannah Pegram, and Helen Kitchen. "P117 CONTENT VALIDITY OF THE SUBCUTANEOUS ADMINISTRATION ASSESSMENT QUESTIONNAIRE (SQAAQ) IN ADULT AND ADOLESCENT PATIENTS WITH MODERATE TO SEVERE CROHN’S DISEASE." Inflammatory Bowel Diseases 26, Supplement_1 (2020): S42—S43. http://dx.doi.org/10.1093/ibd/zaa010.111.

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Abstract Background Subcutaneous (SC) delivery of biologic therapies is typically via a prefilled syringe or an auto-injector designed to offer a more convenient and more consistent administration of drug product. There is currently no gold standard instrument that is used to assess the usability and patient confidence and preference for an injection device in Crohn’s disease (CD). The Subcutaneous Administration Assessment Questionnaire (SQAAQ) was developed to evaluate ease of use and confidence in SC administrations of therapy. The SQAAQ (Figure 1) features 12 items scored on a 7-point Like
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Mulla-Ali, Dalal Hamza, Kevin H. M. Kuo, Ambica Parmar, and Yves D. Pastore. "A Systematic Review of the Classification, Diagnosis, Treatment and Outcome of Osteonecrosis of the Hips in Sickle Cell Disease." Blood 126, no. 23 (2015): 2069. http://dx.doi.org/10.1182/blood.v126.23.2069.2069.

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Abstract Background: Osteonecrosis (ON) is a prevalent (30-50% by age 30) yet underdiagnosed complication in patients with sickle cell disease (SCD), commonly affecting the femoral and humeral head. SCD ON is progressive resulting in chronic intractable pain and disability. Various imaging modalities are available for the diagnosis of ON and a number of staging methods have been proposed to classify its severity. Numerous surgical and non-surgical treatments exist for different stages of ON. There is a lack of consensus on how to best investigate, classify and treat patients with SCD ON. A pre
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Taylor, Bryan C., Lee P. Shulman, Malcolm G. Munro, Stephanie Martin, Anita L. Nelson, and Patricia A. Locantore-Ford. "Advancing OB/GYN Knowledge, Competence, and Performance Related to Abnormal Uterine Bleeding and Intravenous Iron Supplementation for Effective Management of Iron Deficiency Anemia: Outcomes Analysis from a 2019 Educational Initiative." Blood 136, Supplement 1 (2020): 28–29. http://dx.doi.org/10.1182/blood-2020-133836.

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Background: Iron deficiency anemia (IDA) is a multifaceted condition associated with immense obstetrical morbidity and mortality, and is especially prevalent in female patients of reproductive age.Abnormal uterine bleeding (AUB), which often manifests clinically as heavy menstrual bleeding (HMB), is the leading cause of IDA among reproductive age women in the United States, with a prevalence ranging from ~30-50% in this patient population; further, HMB is estimated to account for nearly one-third of all IDA causes worldwide. For these reasons, AUB/HMB is generally accepted as the primary causa
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Srinivas, Meghana, Jennifer Krajewski, Nancy Durning, Melanie Hankewycz, and Alfred Gillio. "Evolution of Moderate Aplastic Anemia into Subclinical PNH/AA and Successful Treatment with Reduced Intensity Haplo-HSCT: A Pediatric Case Report." Blood 134, Supplement_1 (2019): 5027. http://dx.doi.org/10.1182/blood-2019-130407.

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Introduction: Aplastic Anemia (AA) is diagnosis made after the exclusion of other acquired or inherited disease that can present with pancytopenia. In pediatric AA, there is often overlap with many other diseases including Paroxysmal Nocturnal Hemoglobinuria (PNH) and hypocellular myelodysplastic syndrome (MDS). The diagnosis is often difficult and can evolve. There are new tests and methodologies to guide diagnosis and treatment decision making. Case report: The patient is a previously healthy, 18-year-old Caucasian female referred for pancytopenia. Patient reported progressive fatigue and ea
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Sena, Carla Cristina Reinaldo Gimenes de, and Barbara Gomes Flaire Jordão. "The Possibility of Developing Geographic and Cartographic Education using Minecraft." Abstracts of the ICA 2 (October 9, 2020): 1. http://dx.doi.org/10.5194/ica-abs-2-31-2020.

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Abstract. The use of technology is closer and closer to the school, providing new perspectives to the geographic education, which includes the learning of cartography and learning through cartography as being important resources for the geographic space’ analysis. As an example of digital technologies application, this work presents a reflection on the use of virtual environments for the learning diagnosis of geographic and cartographic concepts. Digital games based on construction draw children’s and young people’s attention, and among them, Minecraft is one of the most popular. This is a gam
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McGhee, Jasmine, Karina L. Wilkerson, Deva Sharma, Gina Frieden, and Adetola A. Kassim. "Decreased Hospitalizations and Improved Health-Related Outcomes Using Client-Centered Therapy in Adults with Sickle Cell Disease with High Health Care Utilization." Blood 136, Supplement 1 (2020): 3–4. http://dx.doi.org/10.1182/blood-2020-143278.

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Background:Sickle cell disease (SCD) is a chronic multisystem disorder associated with vaso-occlusive pain and organ damage, leading to substantial morbidity, impaired health-related quality of life, increased health care costs, and a high risk of premature death (Platt el al. N Engl J Med. 1994). SCD complications and pain episodes accounted for 23% of statewide admissions, mainly by a small group of high utilizers. (Woods et al. Public Health Rep, 1997). Adults with SCD have a high rate of depression, 35% compared to 6.7% in the general adult population (Adam, Flahiff, Kamble, et al. 2017).
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Chang, Justin S., Babar Kayani, Ricci Plastow, Sandeep Singh, Ahmed Magan, and Fares S. Haddad. "Management of hamstring injuries: current concepts review." Bone & Joint Journal 102-B, no. 10 (2020): 1281–88. http://dx.doi.org/10.1302/0301-620x.102b10.bjj-2020-1210.r1.

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Injuries to the hamstring muscle complex are common in athletes, accounting for between 12% and 26% of all injuries sustained during sporting activities. Acute hamstring injuries often occur during sports that involve repetitive kicking or high-speed sprinting, such as American football, soccer, rugby, and athletics. They are also common in watersports, including waterskiing and surfing. Hamstring injuries can be career-threatening in elite athletes and are associated with an estimated risk of recurrence in between 14% and 63% of patients. The variability in prognosis and treatment of the diff
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