Relevant bibliographies by topics / Diagnostic label

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Diagnostic label'

Author: Grafiati
Published: 4 June 2021
Last updated: 15 February 2022

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Journal articles on the topic "Diagnostic label"

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Miller-Spoto, Marcia, and Sara P. Gombatto. "Diagnostic Labels Assigned to Patients With Orthopedic Conditions and the Influence of the Label on Selection of Interventions: A Qualitative Study of Orthopaedic Clinical Specialists." Physical Therapy 94, no. 6 (June 1, 2014): 776–91. http://dx.doi.org/10.2522/ptj.20130244.

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Background A variety of diagnostic classification systems are used by physical therapists, but little information about how therapists assign diagnostic labels and how the labels are used to direct intervention is available. Objective The purposes of this study were: (1) to examine the diagnostic labels assigned to patient problems by physical therapists who are board-certified Orthopaedic Clinical Specialists (OCSs) and (2) to determine whether the label influences selection of interventions. Design A cross-sectional survey was conducted. Methods Two written cases were developed for patients with low back and shoulder pain. A survey was used to evaluate the diagnostic label assigned and the interventions considered important for each case. The cases and survey were sent to therapists who are board-certified OCSs. Respondents assigned a diagnostic label and rated the importance of intervention categories for each case. Each diagnostic label was coded based on the construct it represented. Percentage responses for each diagnostic label code and intervention category were calculated. Relative importance of intervention category based on diagnostic label was examined. Results For the low back pain and shoulder pain cases, respectively, “Combination” (48.5%, 34.9%) and “Pathology/Pathophysiology” (32.7%, 57.3%) diagnostic labels were most common. Strengthening (85.9%, 98.1%), stretching (86.8%, 84.9%), neuromuscular re-education (87.6%, 93.4%), functional training (91.4%, 88.6%), and mobilization/manipulation (85.1%, 86.8%) were considered the most important interventions. Relative importance of interventions did not differ based on diagnostic label (χ2=0.050–1.263, P=.261–.824). Limitations The low response rate may limit the generalizability of the findings. Also, examples provided for labels may have influenced responses, and some of the label codes may have represented overlapping constructs. Conclusions There is little consistency with which OCS therapists assign diagnostic labels, and the label does not seem to influence selection of interventions.
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del Mar Montoya-Rodríguez, Mª, and Francisco-Javier Molina-Cobos. "Stigmatizing effects of psychological diagnosis in children." European Journal of Investigation in Health, Psychology and Education 7, no. 1 (February 6, 2017): 47–58. http://dx.doi.org/10.1989/ejihpe.v7i1.194.

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Despite the known advantages of the classification of psychological disorders, using formal diagnostic could reduce a story of life and way of behaving to a mere diagnostic label, becoming a tautological explanation that ignores the true explanation of the problem and adds iatrogenic functions and stigmatizing. The present study assesses the influence of diagnostic labels in the performance of psychologists who evaluate the intelligence of a group of children. The Goodenough Test is used for instrumental reasons. The different drawings of a human figure, made by children with standardized psychological development, were labeled as if having been drawn by children with mental retardation, giftedness and normal development. The results show that evaluators, unaware of the falsity of the diagnoses, score the drawings differentially depending on the diagnostic label used. That is, the results evidence the negative influence of a diagnostic label about expectations and treatment to the person diagnosed.
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del Mar Montoya-Rodríguez, Mª, and Francisco-Javier Molina-Cobos. "Stigmatizing effects of psychological diagnosis in children." European Journal of Investigation in Health, Psychology and Education 7, no. 1 (February 6, 2017): 47–58. http://dx.doi.org/10.3390/ejihpe7010004.

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Despite the known advantages of the classification of psychological disorders, using formal diagnostic could reduce a story of life and way of behaving to a mere diagnostic label, becoming a tautological explanation that ignores the true explanation of the problem and adds iatrogenic functions and stigmatizing. The present study assesses the influence of diagnostic labels in the performance of psychologists who evaluate the intelligence of a group of children. The Goodenough Test is used for instrumental reasons. The different drawings of a human figure, made by children with standardized psychological development, were labeled as if having been drawn by children with mental retardation, giftedness and normal development. The results show that evaluators, unaware of the falsity of the diagnoses, score the drawings differentially depending on the diagnostic label used. That is, the results evidence the negative influence of a diagnostic label about expectations and treatment to the person diagnosed.
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HADLER, N. M. "Is fibromyalgia a useful diagnostic label?" Cleveland Clinic Journal of Medicine 63, no. 2 (March 1, 1996): 85–87. http://dx.doi.org/10.3949/ccjm.63.2.85.

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Jones, R., K. Barraclough, and C. Dowrick. "When no diagnostic label is applied." BMJ 340, may25 2 (May 25, 2010): c2683. http://dx.doi.org/10.1136/bmj.c2683.

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Lam, Danny C. K., Elena V. Poplavskaya, Paul M. Salkovskis, Lorna I. Hogg, and Holly Panting. "An experimental Investigation of the Impact of Personality Disorder Diagnosis on Clinicians: Can We See Past the Borderline?" Behavioural and Cognitive Psychotherapy 44, no. 3 (August 25, 2015): 361–73. http://dx.doi.org/10.1017/s1352465815000351.

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Background: There is concern that diagnostic labels for psychiatric disorders may invoke damaging stigma, stereotypes and misunderstanding. Aims: This study investigated clinicians’ reactions to diagnostic labelling by examining their positive and negative reactions to the label borderline personality disorder (BPD). Method: Mental health professionals (n = 265) viewed a videotape of a patient suffering from panic disorder and agoraphobia undergoing assessment. Prior to viewing the videotape, participants were randomly allocated to one of three conditions and were given the following information about the patient: (a) general background information; (b) additional descriptive information about behaviour corresponding to BPD; and (c) additional descriptive information about behaviour corresponding to BPD, but explicitly adding BPD as a possible comorbid diagnostic label. All participants were then asked to note things they had seen in the videotape that made them feel optimistic or pessimistic about treatment outcome. Results: Participants in the group that were explicitly informed that the patient had a BPD diagnostic label reported significantly fewer reasons to be optimistic than the other two groups. Conclusions: Diagnostic labels may negatively impact on clinicians’ judgments and perceptions of individuals and therefore clinicians should think carefully about whether, and how, they use diagnoses and efforts should be made to destigmatize diagnostic terms.
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Powell, C. V. E., and H. R. Jenkins. "Toddler diarrhoea: is it a useful diagnostic label?" Archives of Disease in Childhood 97, no. 1 (August 9, 2011): 84–86. http://dx.doi.org/10.1136/adc.2010.191825.

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Lokhov, Petr G., Oxana P. Trifonova, Dmitry L. Maslov, and Elena E. Balashova. "In Situ Mass Spectrometry Diagnostics of Impaired Glucose Tolerance Using Label-Free Metabolomic Signature." Diagnostics 10, no. 12 (December 5, 2020): 1052. http://dx.doi.org/10.3390/diagnostics10121052.

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In metabolomics, mass spectrometry is used to detect a large number of low-molecular substances in a single analysis. Such a capacity could have direct application in disease diagnostics. However, it is challenging because of the analysis complexity, and the search for a way to simplify it while maintaining the diagnostic capability is an urgent task. It has been proposed to use the metabolomic signature without complex data processing (mass peak detection, alignment, normalization, and identification of substances, as well as any complex statistical analysis) to make the analysis more simple and rapid. Methods: A label-free approach was implemented in the metabolomic signature, which makes the measurement of the actual or conditional concentrations unnecessary, uses only mass peak relations, and minimizes mass spectra processing. The approach was tested on the diagnosis of impaired glucose tolerance (IGT). Results: The label-free metabolic signature demonstrated a diagnostic accuracy for IGT equal to 88% (specificity 85%, sensitivity 90%, and area under receiver operating characteristic curve (AUC) of 0.91), which is considered to be a good quality for diagnostics. Conclusions: It is possible to compile label-free signatures for diseases that allow for diagnosing the disease in situ, i.e., right at the mass spectrometer without complex data processing. This achievement makes all mass spectrometers potentially versatile diagnostic devices and accelerates the introduction of metabolomics into medicine.
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Dryer, Rachel, Michael J. Kiernan, and Graham A. Tyson. "The Effects of Diagnostic Labelling on the Implicit Theories of Attention-Deficit/Hyperactivity Disorder Held by Health Professionals." Behaviour Change 23, no. 3 (September 1, 2006): 177–85. http://dx.doi.org/10.1375/bech.23.3.177.

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AbstractAttention-deficit/hyperactivity disorder (ADHD) is the most recent diagnostic label used to describe a behavioural condition of which the essential features are developmentally inappropriate levels of inattention, impulsivity and overactivity. ADHD has attracted both controversy and attention from the professional and scientific community. However, little is known regarding the explanatory models (implicit theories) of health professionals or of their beliefs regarding the treatment of this condition, specifically the impact of diagnostic labelling on their decisions concerning treatment. This study manipulated the presence versus absence of the diagnostic label ‘ADHD’ in a vignette study describing the symptoms of this condition. The vignette was presented to professionals in the educational, mental health and allied health fields. After reading the vignette, participants were required to complete a questionnaire examining implicit beliefs concerning ADHD. The results confirmed that the presence of the diagnostic label (ADHD) changed the causal explanations by professional groups. However, the presence of the diagnostic label did not significantly change the beliefs about the optimal treatment strategy for this condition.
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&NA;. "Whatʼs the Least-Offensive Diagnostic Label for Unexplained Symptoms?" Lippincott's Bone and Joint Newsletter 9, no. 2 (February 2003): 14. http://dx.doi.org/10.1097/01300517-200302000-00003.

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Dissertations / Theses on the topic "Diagnostic label"

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Toone, Jared. "Effects of the Diagnostic Label "ADHD " on Peer Judgment." DigitalCommons@USU, 2006. https://digitalcommons.usu.edu/etd/6239.

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Diagnostic labels are frequently used with children exhibiting symptoms of learning and behavioral disorders. The effect that such labels have on the labeled children as well as their peers is not completely understood. In the present study, the effects of the label "ADHD" on peer acceptance were examined. Fourth- and fifth-grade boys and girls viewed a video of a peer listening to teacher instruction and working on a worksheet. For half of the participants, the child in the video was labeled as having ADHD, while the other participants were told nothing about the child. After viewing the video, the children responded to a questionnaire assessing the likelihood that they would befriend the peer in the video. An analysis of variance revealed that the label resulted in significantly lower friendship ratings. Gender of the participant was not found to impact peer ratings. These results indicate that parents, professionals, and children need to be educated about the effects that labels may have and that labels need to be used with caution. Labeled children may also benefit from counseling about how others may respond to their label.
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Parker, Honor Louise. "An exploration of the diagnostic label 'Attention Deficit Hyperactivity Disorder'." Thesis, University of Newcastle upon Tyne, 2017. http://hdl.handle.net/10443/3843.

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The diagnostic label Attention Deficit Hyperactivity Disorder (ADHD) is classed as an acute disorder in the Diagnostic and Statistical Manual of Mental Disorders – Fifth Edition (DSM-V). However, ADHD is contextualised within various disciplines - biomedical, psychological and sociological, each of which provide conflicting discourses that confuse the meaning of this diagnostic label. Research suggests children with ADHD diagnoses experience difficulties in social and educational settings. However, contrasting literature exists regarding how children with ADHD diagnoses view themselves. The first chapter of this thesis critically reviews existing research purporting children with ADHD diagnoses overestimate their social competencies. This overestimation is known as the Positive Illusory Bias (PIB). Three conclusions were drawn from the systematic literature review: research in this area does not account for individual differences between children with ADHD diagnoses, quantitative measurement of children’s self-concept is problematic, the concept of the PIB relies upon the assumption that adults’ views are more valid than children’s and does not consider the impact the label ADHD may have on individuals. The conclusions of this Systematic Literature Review informed the empirical research question; what does the diagnostic label ADHD mean to a diagnosed child and the adults who support him? The empirical research used a qualitative methodology to explore the perceptions of a child who has received an ADHD diagnosis, his mother, his teacher and his learning support assistant (LSA) regarding the meaning and impact of the diagnostic label ADHD. Subsequently, the transcripts of four semi-structured interviews were analysed using Interpretive Phenomenological Analysis (IPA). Three master grouped themes were discovered that encapsulate the participants’ perceptions of the label ADHD; Blame, Fear and Support. The master group themes are discussed in consideration of the findings of the Systematic Literature Review, quotes from the participants’ accounts of their lived experience and my interpretations. Due to the research design and context, this empirical research offers novel findings about the views of different stakeholders regarding the diagnostic label ADHD. The associated implications for educational psychologists are discussed.
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Danner, Maria [Verfasser], and Elisabeth [Akademischer Betreuer] Pollerberg. "Marker-free T cell phenotyping - towards a label-free diagnostic and prognostic platform / Maria Danner ; Betreuer: Elisabeth Pollerberg." Heidelberg : Universitätsbibliothek Heidelberg, 2017. http://d-nb.info/1178008258/34.

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Coda, Sergio. "An investigation of the diagnostic potential of autofluorescence lifetime spectroscopy and imaging for label-free contrast of disease." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/24815.

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The work presented in this thesis aimed to study the application of fluorescence lifetime spectroscopy (FLS) and fluorescence lifetime imaging microscopy (FLIM) to investigate their potential for diagnostic contrast of diseased tissue with a particular emphasis on autofluorescence (AF) measurements of gastrointestinal (GI) disease. Initially, an ex vivo study utilising confocal FLIM was undertaken with 420 nm excitation to characterise the fluorescence lifetime (FL) images obtained from 71 GI samples from 35 patients. A significant decrease in FL was observed between normal colon and polyps (p = 0.024), and normal colon and inflammatory bowel disease (IBD) (p = 0.015). Confocal FLIM was also performed on 23 bladder samples. A longer, although not significant, FL for cancer was observed, in paired specimens (n = 5) instilled with a photosensitizer. The first in vivo study was a clinical investigation of skin cancer using a fibre-optic FL spectrofluorometer and involved the interrogation of 27 lesions from 25 patients. A significant decrease in the FL of basal cell carcinomas compared to healthy tissue was observed (p = 0.002) with 445 nm excitation. A novel clinically viable FLS fibre-optic probe was then applied ex vivo to measure 60 samples collected from 23 patients. In a paired analysis of neoplastic polyps and normal colon obtained from the same region of the colon in the same patient (n = 12), a significant decrease in FL was observed (p = 0.021) with 435 nm excitation. In contrast, with 375 nm excitation, the mean FL of IBD specimens (n = 4) was found to be longer than that of normal tissue, although not statistically significant. Finally, the FLS system was applied in vivo in 17 patients, with initial data indicating that 435 nm excitation results in AF lifetimes that are broadly consistent with ex vivo studies, although no diagnostically significant differences were observed in the signals obtained in vivo.
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Danner, Maria [Verfasser], and G. Elizabeth [Akademischer Betreuer] Pollerberg. "Marker-free T cell phenotyping - towards a label-free diagnostic and prognostic platform / Maria Danner ; Betreuer: Elisabeth Pollerberg." Heidelberg : Universitätsbibliothek Heidelberg, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:16-heidok-222400.

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Schnell, Gilles. "Développement d'approches protéomiques pour l'étude de la borréliose de Lyme." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAF056.

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La borréliose de Lyme est une maladie à transmission vectorielle en forte progression ces dernières années. Après une infection par la bactérie appartenant au complexe Borrelia burgdorferi sensu lato via une piqûre de tique, de multiples troubles (cardiaques, rhumatologiques…) peuvent apparaître. Il n’existe à l’heure actuelle aucun vaccin contre la maladie chez l’homme. De plus, les méthodes actuelles de diagnostic souffrent d’un manque de sensibilité, de spécificité ou de rapidité. Nous avons développé différentes approches protéomiques pour l’étude de cette maladie. Dans un premier temps, nous avons mis en évidence de nouveaux candidats vaccinaux par une approche Ge-LC-MS/MS de type label free. Dans un second temps, nous avons mis au point une méthode de détection de la bactérie dans des biopsies cutanées par spectrométrie de masse ciblée SRM. Nous avons également caractérisé les modifications post-traductionnelles d’une protéine identifiée dans les glandes salivaires de tique, et capable de lyser les fibroblastes. Un dernier volet a concerné l’évaluation de deux instruments et de l’apport de modes d’acquisition originaux pour l’analyse protéomique
Lyme borreliosis has been rising strongly for the last twenty years. After an infection by the bacterium belonging to the Borrelia burgdorferi sensu lato complex through a tick bite, multiple disorders (cardiac, rhumatological…) may appear. There is no current vaccine available for human being. Moreover, actual diagnosis methods lack of sensitivity, specificity and quickness. We developed various proteomic approaches to study the Lyme disease. Firstly, we discovered new vaccine candidates by using a Ge-LC-MS/MS label free approach. Secondly, we set up the detection of the bacteria in human cutaneous biopsies by targeted SRM mass spectrometry. We also characterized the post-translational modifications of a lytic protein present in tick salivary glands. Finally, we evaluated the performances of two instruments and the contribution of original acquisition modes for proteomic analyses
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Camp, Charles Henry Jr. "Label-free flow cytometry using multiplex coherent anti-Stokes Raman scattering (MCARS) spectroscopy." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/42733.

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Over the last 50 years, flow cytometry has evolved from a modest cell counter into an invaluable analytical tool that measures an ever-expanding variety of phenotypes. Flow cytometers interrogate passing samples with laser light and measure the elastically scattered photons to ascertain information about sample size, granularity, and basic morphology. Obtaining molecular information, however, requires the addition of exogenous fluorescent labels. These labels, although a power tool, have numerous challenges and limitations such as large emission spectra and cellular toxicity. To move beyond fluorescent labels in microscopy, a variety of techniques that probe the intrinsic Raman vibrations within a sample have been developed, such as coherent anti-Stokes Raman scattering (CARS) and Raman microspectroscopy. In this dissertation, I present the first development of a label-free flow cytometer that measures the elastically scattered photons and probes the intrinsic Raman vibrations of passing samples using multiplex coherent anti-Stokes Raman scattering (MCARS). MCARS, a coherent Raman technique that probes a large region of the Raman spectrum simultaneously, provides rich molecularly-sensitive information. Furthermore, I present its application to sorting polymer microparticles and its use in two example biological applications: monitoring lipid bodies within cultures of Saccharomyces cerevisiae, a model yeast with numerous human homologs, and monitoring the affect of nitrogen starvation on Phaeodactylum tricornutum, a diatom, which is being genetically engineered to efficiently produce biofuels.
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Foncy, Julie. "Nouvelles technologies intégrées d'adressage et de détection des interactions moléculaires pour application de biopuces en diagnostic moléculaire in vitro." Thesis, Toulouse, INSA, 2013. http://www.theses.fr/2013ISAT0043/document.

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Le marché du diagnostic connait un essor considérable depuis l’avènement de labiologie moléculaire. Plus précis et souvent plus rapide, le diagnostic moléculaire in vitro(DIV) est de plus en plus utilisé dans les laboratoires d’analyses médicales. L’ensemble destests dédiés au marché du DIV répond à des contraintes socio-économiques très précisescomme : la fiabilité du résultat, le délai de réponse court, le faible coût et la facilitéd’utilisation. Les indicateurs socio-économiques montrent que la technologie des biopuces estun potentiel bon candidat pour répondre aux attentes du marché. En effet, cet outil permetl’analyse simultanée de plusieurs dizaines voire centaines de séquences nucléiques et doncl’identification d’autant d’organismes en une seule analyse. Cette technologie s’inscrit encomplément de la PCR en apportant l’avantage de l’analyse multiplexée à moyen débit. Deplus, elle permet de donner une réponse globale de la multiplicité des espèces présentes dansl’échantillon sans avoir besoin de passer par une étape de culture. Néanmoins, cettetechnologie n’est pas optimisée pour le marché du DIV. En effet, son usage est complexe, peurobuste et trop cher pour concurrencer les méthodes actuelles (microbiologie pasteurienne,PCR, Elisa, etc..). Dans le but de réduire le coût de fabrication des biopuces à ADN, il estdonc nécessaire de développer des méthodes alternatives. Dans un premier temps, l’objectif de cette thèse Cifre a été de mettre au point unprototype nouveau de dépôt de biomolécules basé sur la lithographie douce, permettant dedéposer les oligonucléotides sondes de façon multiplexée et selon des motifs micrométriques.Cette nouvelle technologie a été évaluée par rapport aux technologies de références. Puis,nous avons développé un procédé innovant de double fonctionnalisation de surface. Ceprocédé simple et rapide a pour avantages de fonctionnaliser la biopuce avec la chimie desurface et les sondes en une seule étape et d’augmenter les signaux d’hybridation. La secondepartie de la thèse a été de coupler cette nouvelle technologie à la détection des événementsd’hybridation sans marquage en utilisant la diffraction de la lumière. La principale différenceavec la méthode de détection par fluorescence repose sur l’adressage des sondes. En effet, ledépôt doit être réalisé sous forme de réseaux de lignes nanométriques diffractants de façon àce que l'interaction entre les molécules déposées et les cibles qui interagissent soit trèssensible. Cette seconde phase du projet a été très ambitieuse et innovante. La faisabilité decette méthode de détection, démontrée par des simulations théoriques, a fait l’objet d’untravail d’optimisation très important et les résultats obtenus montrent que cette technologiesans marquage est possible
The diagnosis market increased since the advent of molecular biology. More precise and often faster, the in vitro molecular diagnosis (DIV) is more and more used in medical analyses laboratories. DNA chips technology seems to be a good candidate to answer the market expectations. Indeed, this tool allows making several hundreds of analyses simultaneously. Furthermore, it allows giving a global answer of all the present species in the sample without the need of a culture step. Nevertheless, this technology is not optimized for the market of the DIV. Indeed, its use is complex and too expensive in comparison with the current methods (Pasteur microbiology, PCR, Elisa, etc.). So it is necessary to develop an alternative method to reduce the manufacturing cost and simplify the use of DNA chips. First, the goal of this industrial PhD Cifre supported by the Dendris Company was to complete a new prototype of biomolecules deposition based on soft lithography, allowing multiplexing the deposition of oligonucleotides probes along micro and nanometric patterns.This new technology was compared with the reference technologies. Then, we developed an innovative process of surface co-functionalization. This simple and fast process permits to functionalize the DNA chips with both surface chemistry and probes in a single step and to increase the hybridization signals. The second part of this PhD thesis was to couple this new technology with label-free detection using light diffraction. The main difference with fluorescence-based detection was about probes patterning. Indeed, we needed to generate molecular gratings of nanometric lines to diffract efficiently light from a laser beam. We showed that the absolute diffraction intensity increase with the gratings thickness, which is directly correlated with, probes and targets interactions. The second phase of the project was very ambitious and innovative because we demonstrated the feasibility of this label-free detection. And now we can think that this technology will appear as an alternative method for the diagnosis
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bhardwaj, vinay. "Label-free surface-enhanced Raman spectroscopy-linked immunosensor assay (SLISA) for environmental surveillance." FIU Digital Commons, 2015. http://digitalcommons.fiu.edu/etd/2321.

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The contamination of the environment, accidental or intentional, in particular with chemical toxins such as industrial chemicals and chemical warfare agents has increased public fear. There is a critical requirement for the continuous detection of toxins present at very low levels in the environment. Indeed, some ultra-sensitive analytical techniques already exist, for example chromatography and mass spectroscopy, which are approved by the US Environmental Protection Agency for the detection of toxins. However, these techniques are limited to the detection of known toxins. Cellular expression of genomic and proteomic biomarkers in response to toxins allows monitoring of known as well as unknown toxins using Polymerase Chain Reaction and Enzyme Linked Immunosensor Assays. However, these molecular assays allow only the endpoint (extracellular) detection and use labels such as fluorometric, colorimetric and radioactive, which increase chances of uncertainty in detection. Additionally, they are time, labor and cost intensive. These technical limitations are unfavorable towards the development of a biosensor technology for continuous detection of toxins. Federal agencies including the Departments of Homeland Security, Agriculture, Defense and others have urged the development of a detect-to-protect class of advanced biosensors, which enable environmental surveillance of toxins in resource-limited settings. In this study a Surface-Enhanced Raman Spectroscopy (SERS) immunosensor, aka a SERS-linked immunosensor assay (SLISA), has been developed. Colloidal silver nanoparticles (Ag NPs) were used to design a flexible SERS immunosensor. The SLISA proof-of-concept biosensor was validated by the measurement of a dose dependent expression of RAD54 and HSP70 proteins in response to H2O2 and UV. A prototype microchip, best suited for SERS acquisition, was fabricated using an on-chip SLISA to detect RAD54 expression in response to H2O2. A dose-response relationship between H2O2 and RAD54 is established and correlated with EPA databases, which are established for human health risk assessment in the events of chemical exposure. SLISA outperformed ELISA by allowing RISE (rapid, inexpensive, simple and effective) detection of proteins within 2 hours and 3 steps. It did not require any label and provided qualitative information on antigen-antibody binding. SLISA can easily be translated to a portable assay using a handheld Raman spectrometer and it can be used in resource-limited settings. Additionally, this is the first report to deliver Ag NPs using TATHA2, a fusogenic peptide with cell permeability and endosomal rupture release properties, for rapid and high levels of Ag NPs uptake into yeast without significant toxicity, prerequisites for the development of the first intracellular SERS immunosensor.
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Zaccari, Irene. "Multiplexed label-free electronic biosensors for clinical diagnostics." Thesis, University of Leeds, 2013. http://etheses.whiterose.ac.uk/6893/.

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The development of a highly sensitive, label-free, multiplexed biosensor platform for point-of-care diagnostics is presented. The sensor surface of a non-faradaic electrochemical impedance spectroscopy (EIS) immuno-sensor platform was developed and fully characterised. Optimisation of the binding of monoclonal antibodies (mAb) towards the model target human chorionic gonadotropin (hCG) to the OEG self-assembled monolayers (SAMs) was carried out. Optimal conditions for immobilisation were found for buffer pH approximately one unit below the pI of the antibody. The same condition resulted in both higher antibody density on the sensor surface as well as higher response to the antigen. At the same time the surface showed good resistance to non-specific adsorption of proteins. Based on these principles, a biosensor to detect hCG in full serum was demonstrated. By using the phase of the impedance at 100 mHz as the sensor response, a linear relationship of the phase shift vs the logarithm of hCG concentration was established between 2.6 x 10�14 M and 2.6 x 10�10 M with a sensitivity of 0.6 degree per decade, which is a significant improvement over current state-of-the-art biosensor systems. Finally, The dielectric properties of COOH-terminated hexa(ethylene glycol)undecanethiol (OEG) and 11-mercaptoundecanol (MUD) and mixed MUD:OEG SAMs, at different ratios, were studied by means of EIS. The study demonstrates that small amounts of MUD in the mixed MUD:OEG SAMs lead to a considerable decrease of the phase of the impedance as well as a significant increase in the resistivity of the SAM at low frequencies, indicating a significant improvement of the dielectric properties. Furthermore, a considerable change in the formation of clusters of OEG molecules for mixed MUD:OEG SAMs with increasing MUD content was shown by AFM imaging.
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Books on the topic "Diagnostic label"

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When the labels don't fit: A new approach to raising a challenging child. New York: Three Rivers Press, 2008.

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Maes, Pascale. Labels d'efficacite e nerge tique: HQE, BBC-Effinergie, maison passive, RT 2005-2012, Qualitel. Paris: Eyrolles, 2009.

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The myth of the A.D.D. child: 50 ways to improve your child's behavior and attention span without drugs, labels, or coercion. New York: Dutton, 1995.

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Arbel, Tal, M. Jorge Cardoso, Simone Balocco, Lena Maier-Hein, Su-Lin Lee, Veronika Cheplygina, Diana Mateus, Guillaume Zahnd, and Stefanie Demirci. Intravascular Imaging and Computer Assisted Stenting, and Large-Scale Annotation of Biomedical Data and Expert Label Synthesis. Springer, 2017.

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Trucco, Emanuele, Pierre Jannin, Danail Stoyanov, Simone Balocco, Eric Granger, Zeike Taylor, Anne Martel, et al. Intravascular Imaging and Computer Assisted Stenting and Large-Scale Annotation of Biomedical Data and Expert Label Synthesis: 7th Joint International ... Springer, 2018.

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Reuber, Markus. Communicating the Diagnosis. Edited by Barbara A. Dworetzky and Gaston C. Baslet. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190265045.003.0010.

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Psychogenic nonepileptic seizures (PNES) can stop after the communication of the diagnosis by a healthcare professional, or PNES disorders can become more entrenched and patients are less able to control their seizures. This chapter addresses strategies for the explanation of the diagnosis of PNES, compares their effectiveness, and offers recommendations for delivering the diagnosis. A “positive” diagnostic label (such as “dissociative attacks”) may have advantages over a “negative” label (stating what the problem is not). Explaining PNES as a reflex response to potentially threatening triggers may be acceptable to PNES patients, who tend to experience PNES as a “physical” problem, while providing a rationale for psychological treatment interventions. However, PNES are a heterogeneous disorder and explanations have to be adapted to fit particular patients’ circumstances. How the diagnosis is communicated may be more important than what words are used for the disorder. Additional resources such as leaflets or websites may help patients understand their problem better. The explanation to patients should be followed by clear communication of the diagnosis to other health professionals involved in the patient’s care.
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When the Labels Don't Fit. New York: Crown Publishing Group, 2008.

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Biomedical Imaging The Chemistry Of Labels Probes And Contrast Agents. Royal Society of Chemistry, 2011.

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Krowchuk, Heidi Vonkoss. THE EFFECTS OF STEREOTYPES AND DIAGNOSTIC LABELS ON THE CLINICAL INFERENCES OF NURSES. 1988.

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Tatlisumak, Turgut, and Lars Thomassen, eds. Ischaemic Stroke in the Young. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198722366.001.0001.

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Stroke in the young is different, complex, and challenging. This book delivers a comprehensive review of the different aspects of young ischaemic stroke. Incidence, risk factors, and aetiology differ notably from those seen in the elderly. There is an increased prevalence of traditional risk factors already at a young age, but the book also focuses on special risk factors in young stroke patients. In many young stroke patients, aetiology remains unclear. The book outlines an extensive diagnostic workup and a stroke subtype classification adapted for young strokes. Gender differences are prevalent in young stroke. The book describes risk factors that are either unique or more prevalent in women and the importance of treating them aggressively. Stroke symptoms in children are comparable to those in adults, but there is a dramatic bystander delay in diagnosing the stroke. The text therefore also deals with rapid stroke recognition and adaption to the special needs in children. Young stroke patients are under-represented in randomized controlled treatment trials. In the emergency setting, unusual clinical findings and off-label situations may be faced and the decision-making process may be challenging. Recommendations for secondary prevention are also mainly extrapolated from studies in older individuals. The authors extrapolate data and draw conclusions on the acute and prophylactic treatment of young stroke. Prognosis after young stroke is poor. Even minor stroke may have devastating life-long consequences for quality of life, education, and working capacity. The book points to the opportunity for lifelong prevention of vascular events.
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Book chapters on the topic "Diagnostic label"

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Massad-Ivanir, Naama, Giorgi Shtenberg, and Ester Segal. "Advancing Nanostructured Porous Si-Based Optical Transducers for Label Free Bacteria Detection." In Nano-Biotechnology for Biomedical and Diagnostic Research, 37–45. Dordrecht: Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-94-007-2555-3_4.

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Levicky, Rastislav, Ursula Koniges, and Napoleon Tercero. "Diagnostic Applications of Morpholinos and Label-Free Electrochemical Detection of Nucleic Acids." In Morpholino Oligomers, 181–90. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6817-6_15.

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Jansson, Åsa. "Conclusion: Melancholia, Depression, and the Politics of Classification." In From Melancholia to Depression, 209–28. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-54802-5_7.

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Abstract The conclusion briefly highlights some alternative models of melancholia at the turn of the twentieth century, before turning the focus to the decline of the melancholia diagnosis and the rise of clinical depression as the new dominant mood disorder in diagnostic literature. The Conclusion considers how the developments outlined in the previous chapters have been foundational not only for the modern psychiatric concepts ‘mood disorder’ and ‘clinical depression’, but also more broadly for classification and clinical practice in twentieth- and twenty-first-century psychiatry. Finally, the book turns the spotlight to the politics of psychiatric classification, and asks what is at work, and at stake, when psychiatry tries to label, classify, and diagnose psychological distress.
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Wang, Huazhen, Junlong Liu, Sisi Lai, Nengguang Wu, and Jixiang Du. "CP-MCNN: Multi-label Chest X-ray Diagnostic Based on Confidence Predictor and CNN." In Security, Privacy, and Anonymity in Computation, Communication, and Storage, 207–17. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-24900-7_17.

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Hens, Kristien, and Raymond Langenberg. "Immeasurability, Biology, Identity. Citizenship and the Meaning of a Diagnostic Label for Adults Diagnosed with Autism." In Citizenship in Organizations, 201–23. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-60237-0_11.

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Karri, Jay, George C. Chang Chien, and Alaa Abd-Elsayed. "Diagnostic Labels for Musculoskeletal Pain." In Pain, 661–68. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-99124-5_144.

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Hobro, Alison J., and Nicholas I. Smith. "Label-Free Raman Imaging." In Nanotechnology Characterization Tools for Biosensing and Medical Diagnosis, 277–331. Berlin, Heidelberg: Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-56333-5_7.

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Smith, Gerrilyn. "Diagnostic Labels Across the Life Span." In Working with Trauma, 7–28. London: Macmillan Education UK, 2013. http://dx.doi.org/10.1007/978-1-137-01558-7_2.

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Haab, Brian B. "Multiplexed Protein Analysis Using Antibody Microarrays and Label-Based Detection." In Microarrays in Clinical Diagnostics, 183–94. Totowa, NJ: Humana Press, 2005. http://dx.doi.org/10.1385/1-59259-923-0:183.

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Glinka, Kinga, Agnieszka Wosiak, and Danuta Zakrzewska. "Improving Children Diagnostics by Efficient Multi-label Classification Method." In Advances in Intelligent Systems and Computing, 253–66. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-39796-2_21.

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Conference papers on the topic "Diagnostic label"

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Zaccari, Irene, A. Giles Davies, Christoph Walti, and Sophie X. Laurenson. "Label-free electrochemical biosensors for clinical diagnostic." In 2014 Cairo International Biomedical Engineering Conference (CIBEC). IEEE, 2014. http://dx.doi.org/10.1109/cibec.2014.7020946.

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Pesen, Medine Tuna, Gunay Basar, Ugur Parlatan, Bahar Yuksel, Engin Oral, Ercan Bastu, and Mehmet Burçin Ünlü. "Raman spectroscopy as a diagnostic method for endometriosis disease (Conference Presentation)." In Label-free Biomedical Imaging and Sensing (LBIS) 2019, edited by Natan T. Shaked and Oliver Hayden. SPIE, 2019. http://dx.doi.org/10.1117/12.2506997.

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Tsai, Shang-Chi, Chao-Wei Huang, and Yun-Nung Chen. "Modeling Diagnostic Label Correlation for Automatic ICD Coding." In Proceedings of the 2021 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies. Stroudsburg, PA, USA: Association for Computational Linguistics, 2021. http://dx.doi.org/10.18653/v1/2021.naacl-main.318.

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Rius, Cristina, Tobias N. Ackermann, Beatriz Dorado, Xavier Muñoz-Berbel, Vicente Andrés, and Andreu Llobera. "Fiber optic label-free biophotonic diagnostic tool for cardiovascular disease." In SPIE Microtechnologies, edited by Sander van den Driesche. SPIE, 2015. http://dx.doi.org/10.1117/12.2179062.

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Bec, Julien, Deborah vela, L. Maximilian Buja, Kenneth B. Margulies, and Laura Marcu. "Label-free assessment of biochemical markers of atherosclerotic plaque progression using intravascular fluorescence lifetime." In Diagnostic and Therapeutic Applications of Light in Cardiology 2021, edited by Laura Marcu and Gijs van Soest. SPIE, 2021. http://dx.doi.org/10.1117/12.2579155.

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Mannoh, Emmanuel A., Logan B. Parker, Giju Thomas, Carmen C. Solórzano, and Anita M. Mahadevan-Jansen. "A multimodal imaging system for label-free parathyroid gland identification and vascularity assessment." In Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIX, edited by Caroline Boudoux and James W. Tunnell. SPIE, 2021. http://dx.doi.org/10.1117/12.2583235.

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Mugnano, Martina, Pasquale Memmolo, Lisa Miccio, Francesco Merola, Vittorio Bianco, Antonella Gambale, Roberta Russo, Immacolata Andolfo, Achille Iolascon, and Pietro Ferraro. "Diagnostic decision support tool for anemias based on label-free holographic imaging." In Advances in Microscopic Imaging, edited by Francesco S. Pavone, Emmanuel Beaurepaire, and Peter T. So. SPIE, 2019. http://dx.doi.org/10.1117/12.2527136.

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Tsai, Shang-Chi, Ting-Yun Chang, and Yun-Nung Chen. "Leveraging Hierarchical Category Knowledge for Data-Imbalanced Multi-Label Diagnostic Text Understanding." In Proceedings of the Tenth International Workshop on Health Text Mining and Information Analysis (LOUHI 2019). Stroudsburg, PA, USA: Association for Computational Linguistics, 2019. http://dx.doi.org/10.18653/v1/d19-6206.

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Li, Cai, James F. Mcmasters, Alba Alfonso García, Julien Bec, Anne K. Haudenschild, Alyssa Panitch, Leigh G. Griffiths, and Laura Marcu. "Study of vascular tissue grafts cellularization process in bioreactors using label-free fluorescence lifetime imaging (Conference Presentation)." In Diagnostic and Therapeutic Applications of Light in Cardiology 2019, edited by Kenton W. Gregory and Laura Marcu. SPIE, 2019. http://dx.doi.org/10.1117/12.2510823.

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Lima, Cássio A., Luciana Correa, Hugh Byrne, and Denise M. Zezell. "Label-free infrared spectroscopic imaging for characterization of necrotic tissue areas on cutaneous squamous cell carcinoma." In Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII, edited by Anita Mahadevan-Jansen. SPIE, 2019. http://dx.doi.org/10.1117/12.2510711.

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Reports on the topic "Diagnostic label"

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Leverett, Justin. Stigmatization and Mental Illness: The Communication of Social Identity Prototypes through Diagnosis Labels. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.6565.

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