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Relevant bibliographies by topics / Diagnostical skin diseases

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Academic literature on the topic 'Diagnostical skin diseases'

Author: Grafiati

Published: 30 May 2022

Last updated: 31 May 2022

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Journal articles on the topic "Diagnostical skin diseases"

1

Hugo, Jan. "Common errors in diagnosing skin diseases in pediatrician's office." Pediatrie pro praxi 18, no. 5 (November 1, 2017): 288–96. http://dx.doi.org/10.36290/ped.2017.056.

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2

Lindblad, R., Aurore Al-Obaidy, H. Mobacken, and S. Rödjer. "Diagnostically Usable Skin Lesions in Candida Septicaemia Diagnostisch verwertbare Hautverinderungen bei Candida-Septikämie." Mycoses 32, no. 8 (April 24, 2009): 416–20. http://dx.doi.org/10.1111/j.1439-0507.1989.tb02273.x.

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3

Akshaya, R. C., R. Sathyanarayanan, C. R. V. Narasimhalu, and Sonti Sulochana. "ANCA Associated vasculitis- A case of microscopic polyangiitis with proliferative glomerulonephritis." Biomedicine 41, no. 3 (October 25, 2021): 686–89. http://dx.doi.org/10.51248/.v41i3.1208.

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Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) are a collection of diseases, characterised by destruction and inflammation of small and medium vessels. Microscopic Polyangiitis (MPA) is part of an ANCA-associated vasculitis (AAV).The clinical signs diverge and disturba number of organs such as the kidneys, lungs, stomach and intestine. Skin manifestations such as purpuric, urticarial, nodular, ulcerative, livedoid and necrotic skin lesions were common as in other vaso-occlusive disorder. Morphology and added features aid the diagnostic approach. Here, we report a diagnostically challenging case of microscopic polyangiitis with progressive glomerulonephritis.

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4

Kubanova, A. A., A. A. Kubanov, V. A. Smolyannikova, N. V. Gribanov, and YU B. Makhakova. "Diagnostic value of the confocal laser scanning microscopy in vivo." Vestnik dermatologii i venerologii 91, no. 3 (June 24, 2015): 67–74. http://dx.doi.org/10.25208/0042-4609-2015-91-3-67-74.

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The confocal laser scanning microscopy in vivo is a promising study method to visualize cell structures of epidermis and papillary dermis without affecting the skin integrity, which provides for a resolution and contrast similar to those characteristic of the classical histology examination. Goal. To assess the confocal laser scanning microscopy in vivo (CLSM) technique for diagnosing actinic keratosis, psoriasis vulgaris and rosacea vs. the classical histology examination. Study materials. The article describes the results obtained by using the confocal laser scanning microscopy in vivo technique vs. the histology examination in 10 patients with erythematous actinic keratosis, 10 patients with extensive psoriasis and 10 patients with erythematous and papulous rosacea. Results. The article describes diagnostically significant signs of the diseases detected by using the confocal laser scanning microscopy in vivo as well as the potential of this method in terms of diagnosing inflammatory skin diseases.

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Bartold, Magdalena, and Joanna Matowicka-Karna. "Neopterin as a marker of inflammation." Diagnostyka Laboratoryjna 51, no. 2 (July 13, 2015): 153–56. http://dx.doi.org/10.5604/01.3001.0004.1550.

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Neopterin is a non-specific marker of immunological response of human body of cellular type. It belongs to the chemical group known as pteridines. Neopterin has been widely associated with inter alia viral infections, bacterial infections (by intracellular living bacteria), parasitic infections, skin burns or autoimmune diseases. Neopterin is a very important parameter diagnostically not only in diagnosis and monitoring of treatment but also a reliable indicator of macrophages’ activity. Most frequently neopterin concentration is measured in body fluids like blood, serum or urine, but it may be used as an indicator in other body fluids.

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6

SARIDOMICHELAKIS (Μ. Ν. ΣΑΡΙΔΟΜΙΧΕΛΑΚΗΣ), M. N., and A. F. KOUTINAS (Α.Φ. ΚΟΥΤΙΝΑΣ). "Canine atopic dermatitis (atopy)." Journal of the Hellenic Veterinary Medical Society 49, no. 1 (January 31, 2018): 16. http://dx.doi.org/10.12681/jhvms.15734.

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Canine atopic dermatitis is a common clinical entity, characterized by pruritus due to sensitization against common enviromental allergens. It has been proven that there is strong breed predisposition. Genetically programmed dogs overproduct reaginic antibodies (IgE and/or IgGd) after their exposure to airborne allergens (dust mites, epithelia, pollens and molds) which consequently fix themselves to the mast cells of the skin. After reexposure to the same allergens these cells degranulate, with subsequent release of many pharmacologically active substances (histamine, leucotrienes, Prostaglandines etc). However, this is a rather simplistic explanation; the true pathogenesis of atopy is more complicated and still not well understood. Clinical signs first appear between 6 months and 3 years of age. Pruritus, the mainstay of atopy, can be seasonal or perennial. Skin lesions, appearing in later, are attributed to pruritus and/or to secondary complications (staphylococcal pyoderma, seborrhea, dry skin, Malassezia dermatitis). The diagnosis, based on history and clinical findings, necessitates exclusion of other pruritic skin diseases and identification of the offending allergens by using the intradermal test and/or serology (ELISA, RAST). The latter method is diagnostically inferior to intradermal skin test due to the high rate of false positive reactions. Therapeutic options include avoidance of the allergens responsible for sensitization, systemic therapy with glucocorticoids, antihistamines and essential fatty acids in various combinations, topical antipruritic therapy, hyposensitization which is the best therapeutical modality for the perennial form of the disease and management of secondary complications as well as of other concurrent allergic skin diseases, such as food and flea allergy.

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7

Malyshenko, O. S., T. A. Raskina, Yu V. Averkieva, T. V. Protasova, and A. M. Dubaeva. "Articular syndrome in an HIV-infected patient." Modern Rheumatology Journal 14, no. 4 (November 25, 2020): 161–64. http://dx.doi.org/10.14412/1996-7012-2020-4-161-164.

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Nowadays, HIV infection is one of the leading health problems. Its clinical signs are extremely diverse and are associated with many diseases, including rheumatic diseases. This paper describes the course of articular syndrome in a patient with HIV infection. In the patient given, asymmetric arthritis of the left wrist, first metacarpophalangeal, and knee joints with no damage to the skin and mucous membranes or enthesitis, a negative HLA-B27 test, and the whole clinical picture, as well as no convincing evidence of rheumatic diseases might suggest the presence of arthritis associated with HIV infection. The diagnosis of HIV infection was verified using enzyme immunoassay. Today, knowledge continues to accumulate about the features of the course of joint damages and another rheumatic disease in the presence of HIV infection. The possibility of its existence to mask a rheumatic disease, as well as the mutual aggravation of any of the diseases and AIDS, should be taken into account in the practice of physicians of all specialties, especially in the inpatient setting where difficult and diagnostically difficult cases concentrate.

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8

Buczek, Weronika, Alicja M. Buczek, Katarzyna Bartosik, and Alicja Buczek. "Comparison of Skin Lesions Caused by Ixodes ricinus Ticks and Lipoptena cervi Deer Keds Infesting Humans in the Natural Environment." International Journal of Environmental Research and Public Health 17, no. 9 (May 10, 2020): 3316. http://dx.doi.org/10.3390/ijerph17093316.

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Background: The territorial expansion and increased population size of haematophagous arthropods (i.e., the castor bean tick Ixodes ricinus (Ixodida: Ixodidae) and the deer ked Lipoptena cervi (Diptera: Hippoboscidae)) has enhanced the risk of human infestations in Europe. The aim of our study was to present skin lesions induced by tick and deer ked bites in patients from recreational forest regions in southeastern Poland and pay attention to features of skin changes that may be useful in differential diagnosis. Methods: We compare the skin lesions after I. ricinus and L. cervi bite and draw attention to the biological and ecological traits of both ectoparasites, which may be diagnostically relevant for determination of the cause of skin symptoms reported by patients. Results: I. ricinus bites lead to development of erythematous-infiltrative poorly demarcated lesions with a centrally located bite mark, which usually disappears within one to several days. In turn, L. cervi bites leave irregularly shaped scattered erythematous papules. The papules may persist for up to one year and are accompanied by itching. Conclusions: Correct assessment of the clinical picture and its association with an arthropod bite (e.g., tick or deer ked) is highly important for further diagnostic procedures (i.e., differentiation of skin lesions developing in tick-borne diseases and, consequently, correct choice of pharmacological therapy). I. ricinus and L. cervi differ in their developmental cycles and rhythms of activity, which indicates that both species should be considered potential causative agents in the differential diagnosis of skin lesions when the patient has been bitten by an arthropod in autumn and winter months.

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9

Moreira, Diego Henrique, Lorranne Dias Lima, Hernani Lopes Santana, Yasmin Pugliese, Osvaldo Pinto Neto, Virgilio Ribeiro Guedes, and Nilo Fernandes da Costa. "Hanseníase virchowiana e múltiplas reações em paciente atendido pela primeira vez na dermatologia." Revista de Patologia do Tocantins 4, no. 4 (November 28, 2017): 13. http://dx.doi.org/10.20873/uft.2446-6492.2017v4n4p13.

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A Hanseníase é um problema de saúde pública, devido a sua endemicidade em todo território brasileiro. Esta afecção crônica é causada pela Mycobacterium leprae, um bacilo álcool-ácido resistente, de alta infectividade e baixa patogenicidade. Relaciona-se com uma grande variedade de lesões cutâneas. O objetivo deste artigo é apresentar um caso de hanseníase virchowiana diagnosticado em fase avançada e com manifestações clínicas exuberantes; caso que, felizmente, é pouco comum, na atualidade. Palavras-chave: Hanseníase. Hanseníase Virchowiana. Doenças endêmicas. Leprosy is a public health problem due to its endemicity throughout Brazil. This chronic disease is caused by Mycobacterium leprae, a bacillus resistant acid-high infectivity and low pathogenicity. It relates to a variety of skin lesions. The aim of this paper is to present a case of lepromatous leprosy diagnosed at an advanced stage and with exuberant clinical manifestations; case, fortunately, is not common today. Keywords: Leprosy. Leprosy, lepromatous. Endemic diseases.

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10

Rzepka, Zuzanna, Mateusz Maszczyk, and Dorota Wrześniok. "Biological function of cobalamin: causes and effects of hypocobalaminemia at the molecular, cellular, tissue and organism level." Postępy Higieny i Medycyny Doświadczalnej 74 (October 28, 2020): 443–51. http://dx.doi.org/10.5604/01.3001.0014.4741.

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Cobalamin (vitamin B12) is a complex compound, which is classified as a water-soluble vitamin. Absorption of cobalamin in the gut and its transport to cells is a unique process, in which many proteins are involved. The loss of function of these proteins causes serious cell homeostasis disturbance, which may result in the dysfunction of many tissues and organs. Vitamin B12, a cofactor of methionine synthase, provides methylation process and nucleic acid synthesis. Cobalamin is also necessary for methylmalonyl-CoA mutase activity. The enzyme synthesizes succinyl-CoA, an intermediate in tricarboxylic acid cycle. Vitamin B12 deficiency is an important and current health problem. It may be caused by insufficient dietary intake, age, or disease-related malabsorption and genetic defects of mechanisms involved in the absorption, transport and metabolism of cobalamin. Hypocobalaminemia can also result from long-term pharmacotherapy with medicines: metformin, proton pump inhibitors (e.g. omeprazole) and H2-receptor antagonists (e.g. ranitidine). Significant clinical symptoms of cobalamin deficiency include hematological abnormalities, mainly megaloblastic anemia, as well as neurological disorders resulting from degeneration within the nervous system. Early diagnosis and starting treatment with vitamin B12 increase chances for a complete cure. Therefore, the diagnostically important symptom of hypocobalaminemia may be skin manifestations, mainly hyperpigmentations, but also premature graying of hair. The aim of this review article was to summarize the current state of knowledge on the biological function of cobalamin, as well as the causes and consequences of its deficiency at the molecular, cellular, tissue and organism level.

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Dissertations / Theses on the topic "Diagnostical skin diseases"

1

Isaeva, O., and О. Г. Аврунін. "Development of an automated system for video dermatoscopy." Thesis, KNURE, 2019. http://openarchive.nure.ua/handle/document/10198.

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2

Steiner, Markus F. C. "Workplace health surveillance for occupational skin diseases : diagnostic accuracy and reliability of a teledermatology tool." Thesis, University of Aberdeen, 2011. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=186732.

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Occupational skin diseases is one of the most commonest occupational disease groups accounting for about a fifth of all occupational diseases in the UK. Current guidance from the HSE for skin health surveillance is the skin inspection by a responsible person in the workplace. The use of teledermatology can be attractive to reliably conduct skin surveillance in the workplace, and a tool box to take reproducible standardised photographs from the hands of workers in the workplace was developed. Aim of this thesis was to assess diagnostic accuracy and validity of this toolkit with visual inspection as criterion standard for the presence of minor or major hand dermatitis and by scoring the hands and photographs with the validated Hand Eczema Severity Index. Workers from four different occupations were recruited over a 7 month period and 332 workers were assessed on a repeatedly basis producing 1212 assessments. Skin hydration and transepidermal water loss was measured and a symptoms questionnaire was completed by every participant. A high prevalence of skin problems was found in our study: 70% of the participants presented at least once over the study period with minor or major skin symptoms. A high intrarater reliability compared to the visual assessment was shown for the teledermatologic assessment with an agreement of 88%, kappa of 0.79, and a positive likelihood ratio of 7.4 and negative likelihood ratio of 0.07; about 5% of participants with normal skin were over-diagnosed compared to the visual inspection. The interrater reliability was low. The biophysical parameter did not distinguish between normal and affected skin. The tool kit has shown to produce reliable and standardised high quality photographs, the assessment of the photographs showed a very good intrarater agreement to the criterion standard. The toolkit would allow regular skin surveillance with minimal interruption in the workplace and with reliable results from the assessment.

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3

Bagla, Victor P. "The demonstration of lumpy skin disease virus in semen of experimentally infected bulls using different diagnostic techniques." Electronic thesis, 2006. http://upetd.up.ac.za/thesis/available/etd-05272008-120446/.

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4

Tuppurainen, Eeva S. M. "The detection of lumpy skin disease virus in samples of experimentally infected cattle using different diagnostic techniques." Diss., University of Pretoria, 2004. http://upetd.up.ac.za/thesis/available/etd-03082005-101059/.

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5

Bagla, Victor Patrick. "The demonstration of lumpy skin disease virus in semen of experimentally infected bulls using different diagnostic techniques." Diss., University of Pretoria, 2006. http://hdl.handle.net/2263/25041.

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Lumpy skin disease virus (LSDV), a poxvirus that belongs to the genus Capripoxvirus is an important pathogen that can be shed in the semen of infected bulls. The screening of semen for infectious virus prior to artificial insemination requires a sensitive diagnostic method. The isolation of the virus on cell cultures and/or the use of polymerase chain reaction (PCR) are sensitive diagnostic tests which can be used to screen semen for LSD viral DNA prior to artificial insemination. Although cell culture is a sensitive method and detects infectious virus, its use has major limitations due to the toxic effect of semen on the cells. This study was therefore aimed at finding a method that decreases the toxic effect of semen on cell culture and enhances LSDV isolation. Secondly, the efficiency of this method in enhancing the isolation of LSDV in field samples was tested. In order to eliminate the toxic effect of semen on cell culture, a pilot study was conducted in which semen samples from LSDV sero-negative bulls were collected and infected with a field isolate of LSDV, strain 248/93 with a titre of 6.5 log TCID50. The semen samples were subjected to one of four different methods, viz centrifugation, serial dilution, filtration and chemical treatment with kaolin. The centrifugation, serial dilution, and filtration methods were supplemented with additional amounts of gentamycin. The toxic effects of semen on cell culture were completely eliminated when supernatants of semen samples, centrifuged at 2000 rpm for 1, 3 and 5 mins and serial diluted was used to inoculate confluent monolayers of bovine dermis cells. Semen diluted in MEM with or without additional antibiotics was the most sensitive method of demonstrating virus at higher dilutions, followed by pellets of samples centrifuged for 1 and 3 minutes. The toxicity recorded when the pellet fraction of semen samples were centrifuged for 5 mins at 2000 rpm was comparable to results obtained from serially diluted samples supplemented with gentamycin. The use of filtration and kaolin treatment of semen samples could not remove the toxic effect of semen on cells. To evaluate the presence of LSDV in semen of experimentally infected bulls, six seronegative post-pubertal bulls housed in an insect proof facility were infected with LSDV via the intravenous route. The experimentally infected bulls were monitored for clinical sign of the disease. Two bulls showed severe, two a mild and two an inapparent infection. Blood samples were collected for virus isolation and semen samples for virus isolation and PCR. Vesicular fluid and preputial washes were also investigated for the presence of LSD viral nucleic acid using PCR. The infectious titre of the virus shed in semen of these bulls was also calculated. The incubation period in infected bulls varied from 7 to 14 days. The length of viraemia varied between groups and did not correlate with the severity of clinical disease. The virus was isolated from blood samples of bulls in the severely infected group on several occasions. Bulls in the mildly infected group had the lowest rate of isolated virus when compared to those with inapparent infection. The use of supernatants of centrifuged serial diluted semen samples, as shown in the pilot study, have considerably reduced the toxic effect of semen on cell culture. This method was used to test field samples for its sensitivity to isolated LSDV in semen of experimentally infected bulls with PCR as a gold standard. In all the semen samples tested using supernatants of semen samples LSDV was isolated in 53.1% of the samples on cell culture while in the serial diluted samples, only 28.1% of samples were positive with a median time of detection on cell culture of 4 and 8 days, respectively. The use of the supernatant fraction was able to detect infectious LSDV in semen samples for prolonged periods with reduced time of development of cytopathic effect, than previously reported. In order to compare the sensitivity of PCR and virus isolation, PCR positive and a few negative samples were subjected to virus isolation using the centrifugation method developed in the pilot study. The PCR was able to detect LSD viral nucleic acids in some semen samples even when virus could not be isolated on cell culture. The PCR was also able to detect viral nucleic acid in vesicular fluid and preputial washes of infected bulls. The titre of the virus shed in the semen at a certain stage of the infection was calculated to be 3 log TCID50. In conclusion, this study provides evidence of a complete reduction of the toxic effect of semen on cell culture and increase chances of LSDV isolation with reduced detection time when semen samples are processed using the centrifugation method as described in the pilot study. Furthermore, it showed PCR was more sensitive than virus isolation in the detection of LSD viral nucleic acid in semen samples and can be used for routine diagnosis. However, virus isolation must be used when the infective nature of virus shed in semen is desirable. This study provides the first evidence of the shedding of LSDV nucleic acid in vesicular fluid and preputial washes of experimentally infected bulls. It also represents the first report that a considerable amount of LSDV is shed in semen of experimentally infected bulls, which may be infective at certain stages of clinical disease. Lumpy skin disease virus (LSDV), a poxvirus that belongs to the genus Capripoxvirus is an important pathogen that can be shed in the semen of infected bulls. The screening of semen for infectious virus prior to artificial insemination requires a sensitive diagnostic method. The isolation of the virus on cell cultures and/or the use of polymerase chain reaction (PCR) are sensitive diagnostic tests which can be used to screen semen for LSD viral DNA prior to artificial insemination. Although cell culture is a sensitive method and detects infectious virus, its use has major limitations due to the toxic effect of semen on the cells. This study was therefore aimed at finding a method that decreases the toxic effect of semen on cell culture and enhances LSDV isolation. Secondly, the efficiency of this method in enhancing the isolation of LSDV in field samples was tested. In order to eliminate the toxic effect of semen on cell culture, a pilot study was conducted in which semen samples from LSDV sero-negative bulls were collected and infected with a field isolate of LSDV, strain 248/93 with a titre of 6.5 log TCID50. The semen samples were subjected to one of four different methods, viz centrifugation, serial dilution, filtration and chemical treatment with kaolin. The centrifugation, serial dilution, and filtration methods were supplemented with additional amounts of gentamycin. The toxic effects of semen on cell culture were completely eliminated when supernatants of semen samples, centrifuged at 2000 rpm for 1, 3 and 5 mins and serial diluted was used to inoculate confluent monolayers of bovine dermis cells. Semen diluted in MEM with or without additional antibiotics was the most sensitive method of demonstrating virus at higher dilutions, followed by pellets of samples centrifuged for 1 and 3 minutes. The toxicity recorded when the pellet fraction of semen samples were centrifuged for 5 mins at 2000 rpm was comparable to results obtained from serially diluted samples supplemented with gentamycin. The use of filtration and kaolin treatment of semen samples could not remove the toxic effect of semen on cells. To evaluate the presence of LSDV in semen of experimentally infected bulls, six seronegative post-pubertal bulls housed in an insect proof facility were infected with LSDV via the intravenous route. The experimentally infected bulls were monitored for clinical sign of the disease. Two bulls showed severe, two a mild and two an inapparent infection. Blood samples were collected for virus isolation and semen samples for virus isolation and PCR. Vesicular fluid and preputial washes were also investigated for the presence of LSD viral nucleic acid using PCR. The infectious titre of the virus shed in semen of these bulls was also calculated. The incubation period in infected bulls varied from 7 to 14 days. The length of viraemia varied between groups and did not correlate with the severity of clinical disease. The virus was isolated from blood samples of bulls in the severely infected group on several occasions. Bulls in the mildly infected group had the lowest rate of isolated virus when compared to those with inapparent infection. The use of supernatants of centrifuged serial diluted semen samples, as shown in the pilot study, have considerably reduced the toxic effect of semen on cell culture. This method was used to test field samples for its sensitivity to isolated LSDV in semen of experimentally infected bulls with PCR as a gold standard. In all the semen samples tested using supernatants of semen samples LSDV was isolated in 53.1% of the samples on cell culture while in the serial diluted samples, only 28.1% of samples were positive with a median time of detection on cell culture of 4 and 8 days, respectively. The use of the supernatant fraction was able to detect infectious LSDV in semen samples for prolonged periods with reduced time of development of cytopathic effect, than previously reported. In order to compare the sensitivity of PCR and virus isolation, PCR positive and a few negative samples were subjected to virus isolation using the centrifugation method developed in the pilot study. The PCR was able to detect LSD viral nucleic acids in some semen samples even when virus could not be isolated on cell culture. The PCR was also able to detect viral nucleic acid in vesicular fluid and preputial washes of infected bulls. The titre of the virus shed in the semen at a certain stage of the infection was calculated to be 3 log TCID50. In conclusion, this study provides evidence of a complete reduction of the toxic effect of semen on cell culture and increase chances of LSDV isolation with reduced detection time when semen samples are processed using the centrifugation method as described in the pilot study. Furthermore, it showed PCR was more sensitive than virus isolation in the detection of LSD viral nucleic acid in semen samples and can be used for routine diagnosis. However, virus isolation must be used when the infective nature of virus shed in semen is desirable. This study provides the first evidence of the shedding of LSDV nucleic acid in vesicular fluid and preputial washes of experimentally infected bulls. It also represents the first report that a considerable amount of LSDV is shed in semen of experimentally infected bulls, which may be infective at certain stages of clinical disease.
Dissertation (MSc (Veterinary Science))--University of Pretoria, 2006.
Veterinary Tropical Diseases
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6

Garzorz-Stark, Natalie [Verfasser], Kilian G. [Akademischer Betreuer] Eyerich, Carsten [Gutachter] Schmidt-Weber, and Johannes [Gutachter] Ring. "Novel diagnostic tools and markers for inflammatory skin diseases / Natalie Verena Garzorz-Stark. Betreuer: Kilian G. Eyerich. Gutachter: Carsten Schmidt-Weber ; Johannes Ring." München : Universitätsbibliothek der TU München, 2016. http://d-nb.info/1101695153/34.

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Garzorz-Stark, Natalie [Verfasser], Kilian G. Akademischer Betreuer] Eyerich, Carsten [Gutachter] Schmidt-Weber, and Johannes [Gutachter] [Ring. "Novel diagnostic tools and markers for inflammatory skin diseases / Natalie Verena Garzorz-Stark. Betreuer: Kilian G. Eyerich. Gutachter: Carsten Schmidt-Weber ; Johannes Ring." München : Universitätsbibliothek der TU München, 2016. http://nbn-resolving.de/urn:nbn:de:bvb:91-diss-20160512-1293741-1-6.

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8

Gavanescu, Irina Catrinel. "Autoantibodies to Centrosomes are Diagnostic for Human Scleroderma and Can Be Induced by Experimental Mycoplasma Infection in Mice: A Dissertation." eScholarship@UMMS, 2002. https://escholarship.umassmed.edu/gsbs_diss/76.

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The overall objective of this thesis work was to develop new insights into the etiology of scleroderma, a human systemic autoimmune disease, by analyzing the autoantibodies to centrosome antigens that develop during the disease. Centrosomes are perinuclear organelles that form microtubule arrays, including mitotic spindles that ensure the faithful segregation of chromosomes during mitosis. These studies used a novel methodology to determine the prevalence of anti-centrosome autoantibodies in patients with scleroderma. Recombinant centrosome antigens were used to determine the antigenic specificity of anti-centrosome antibody subsets by immunoblotting. Centrosome marker antibodies were used in indirect immunofluorescence assays to distinguish centrosomes within the polymorphic staining pattern frequently given by scleroderma sera. We found that 43% of patients are autoreactive to centrosomes, a prevalence higher than has been reported for any other scleroderma autoantigen. Half of the centrosome-positive patients also had autoantibodies against other antigens used in scleroderma diagnosis. However, in the remaining half of these patients, anti-centrosome antibodies represented the sole class of autoantibodies that was detectable. Anti-centrosome antibodies were detected in only a small percentage of normal individuals and patients with other connective tissue diseases. These data suggest that anti-centrosome autoantibodies may represent a new diagnostic tool in scleroderma. Upon examination of anti-centrosome autoantibody development in an animal model, it appeared that this autoantibody specificity may develop in mice as a consequence of an infection. An infectious agent was isolated by plaque-formation from carrier mice. Further characterization of the infectious agent was undertaken to obtain information on its physical, morphological and cytopathological properties. The infectious agent was identified by sequence and unique antigenic properties to be homologous to the pig pathogen Mycoplasma hyorhinis. When reintroduced into naive mice, the murine mycoplasma triggered anti-centrosome autoantibody development. While anti-centrosome autoantibodies of IgM isotype are part of the repertoire of naive unimmunized mice, mycoplasma infection specifically triggered the development of anti-centrosome IgG. Moreover, centrosome autoreactivity was prevented by antibiotic treatment. The autoantibody response evolved to recruit additional specificities, having IgM isotypes, reactive to endoplasmic reticulum-associated autoantigens.

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9

Djeldjellani, Mohamed. "Étude d'un applicateur destiné à la mesure des propriétés diélectriques de la peau par réflectométrie temporelle." Besançon, 1989. http://www.theses.fr/1989BESA2019.

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Appareil de mesure de la permittivite de la peau "in vivo" en haute frequence (0,1 a 10 ghz). Variations de la dispersion dielectrique dues a l'hydratation, la vascularisation, a l'epaisseur du tissu sous-cutane

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Books on the topic "Diagnostical skin diseases"

1

Molecular diagnostics in dermatology and dermatopathology. New York: Humana Press, 2011.

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Barankin, Benjamin. Diagnostic criteria in dermatology. Lockeport, N.S: Community Books, 2003.

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Hall, John C., Clay J. Cockerell, and Brian J. Hall. Diagnostic pathology: Nonneoplastic dermatopathology. Salt Lake City: Amirsys, 2012.

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Elias, Peter M. Ichthyoses: Clinical, biochemical, pathogenic, and diagnostic assessment. Basel: Karger, 2010.

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Ashton, Richard. Differential diagnosis in dermatology. Oxford: Radcliffe Medical Press, 1990.

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Ashton, Richard. Differential diagnosis in dermatology. Oxford: Radcliffe Medical, 1990.

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Gross, Thelma Lee. Skin diseases of the dog and cat: Clinical and histopathologic diagnosis. 2nd ed. Ames, Iowa: Blackwell Science, 2005.

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Ackerman, A. Bernard. Clues to diagnosis in dermatopathology. Chicago: American Society of Clinical Pathologists Press, 1991.

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Patlak, Margie. Mammography and beyond: Developing technologies for the early detection of breast cancer : a non-technical summary. Edited by National Cancer Policy Board (U.S.). Committee on the Early Detection of Breast Cancer and National Research Council (U.S.). Commission on Life Sciences. Washington, D.C: National Academy Press, 2001.

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Bowling, Jonathan. Diagnostic Dermoscopy: The Illustrated Guide. Wiley & Sons, Incorporated, John, 2011.

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Book chapters on the topic "Diagnostical skin diseases"

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Babiuk, Shawn. "Diagnostic Tools." In Lumpy Skin Disease, 73–79. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-92411-3_16.

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Lovell, C. R., P. J. Maddison, and G. V. Campion. "Common diagnostic problems." In The Skin in Rheumatic Disease, 133–43. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4899-2893-1_11.

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Di Zenzo, Giovanni, Emmanuel Laffitte, Giovanna Zambruno, and Luca Borradori. "Bullous Pemphigoid: Clinical Features, Diagnostic Markers, and Immunopathogenic Mechanisms." In Autoimmune Diseases of the Skin, 65–95. Vienna: Springer Vienna, 2011. http://dx.doi.org/10.1007/978-3-211-99225-8_4.

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Smith, Frances J. D., and W. H. Irwin McLean. "Genodermatoses: Inherited Diseases of the Skin." In Molecular Diagnostics in Dermatology and Dermatopathology, 379–409. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-60761-171-4_19.

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Mukherjee, Pranab K., Nancy Isham, and Mahmoud A. Ghannoum. "Infectious Diseases of the Skin I: Dermatophytosis/Onychomycosis." In Molecular Diagnostics in Dermatology and Dermatopathology, 311–37. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-60761-171-4_15.

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Nikolakis, Georgios, Evgenia Makrantonaki, and Christos C. Zouboulis. "Aging Skin as a Diagnostic Tool for Internal Diseases: A Chance for Dermatology." In Textbook of Aging Skin, 869–85. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-47398-6_125.

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Nikolakis, Georgios, Evgenia Makrantonaki, and Christos C. Zouboulis. "Aging Skin as a Diagnostic Tool for Internal Diseases: A Chance for Dermatology." In Textbook of Aging Skin, 1–17. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27814-3_125-1.

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Murphy, Michael J., and Avery LaChance. "Infectious Diseases of the Skin II: Non-Dermatophytic Infections." In Molecular Diagnostics in Dermatology and Dermatopathology, 339–57. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-60761-171-4_16.

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Park, Gyu Man, Sang Wook Son, Gun Woo Lee, Seung Han Ha, On Seok Lee, Jae Young Kim, and Chil Hwan Oh. "Combined Technology for Measuring Skin Diseases with Molecular Imaging." In Non Invasive Diagnostic Techniques in Clinical Dermatology, 451–70. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-32109-2_41.

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Ardigò, Marco, Marina Agozzino, and Leonardo Abraham. "In Vivo Reflectance Confocal Microscopy for Inflammatory Skin Diseases’ Assessment." In Non Invasive Diagnostic Techniques in Clinical Dermatology, 73–79. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-32109-2_7.

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Conference papers on the topic "Diagnostical skin diseases"

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Tamelo, A. A., N. M. Naumovitch, and D. B. Vladimirov. "System for radiowave diagnostics of oncological skin diseases." In Telecommunication Technology" (CriMiCo 2008). IEEE, 2008. http://dx.doi.org/10.1109/crmico.2008.4676621.

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La Spada, L., R. Iovine, R. Tarparelli, and L. Vegni. "Metamaterial-based sensor for skin disease diagnostics." In SPIE Microtechnologies, edited by Jean-Marc Fédéli, Laurent Vivien, and Meint K. Smit. SPIE, 2013. http://dx.doi.org/10.1117/12.2017561.

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Kostrov, A. V., A. I. Smirnov, A. V. Strikovskiy, D. V. Yanin, G. A. Pantileeva, and Z. V. Davoyan. "Diagnostics of Skin Diseases using the Methods of Near-Field Microwave Sounding." In 2007 17th International Crimean Conference - Microwave & Telecommunication Technology. IEEE, 2007. http://dx.doi.org/10.1109/crmico.2007.4368947.

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Cataloluk, Hatice, and Metin Kesler. "A diagnostic software tool for skin diseases with basic and weighted K-NN." In 2012 International Symposium on Innovations in Intelligent Systems and Applications (INISTA). IEEE, 2012. http://dx.doi.org/10.1109/inista.2012.6246999.

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Çetingül, Müge Pirtini, Rhoda M. Alani, and Cila Herman. "Detection of Skin Cancer Using Transient/Thermal Imaging." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19193.

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The incidence of melanoma in the United States has been increasing dramatically over the past several years [1] with melanoma currently being the sixth most common cancer in the United States. At present, there are no systemic agents available that significantly extend the lifespan of patients with advanced disease and improved survival relies solely on early detection and adequate surgical management [2]. The need to improve the diagnostic accuracy and sensitivity for skin cancer while increasing biopsy efficiency yields to the implementation of imaging technologies in dermatology. Current in-vivo imaging tools in use including digital photography (total cutaneous imaging or imaging of individual lesions), and dermoscopy are highly subjective and without broadly applicable standards or quantitative criteria.

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Deng, Zhong-Shan, and Jing Liu. "Temperature Nonuniformity During Applying Dynamic Infrared Thermography for Tumor Detection: Impact of Large Vessels." In ASME 2005 International Mechanical Engineering Congress and Exposition. ASMEDC, 2005. http://dx.doi.org/10.1115/imece2005-80192.

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During applying infrared thermography for detection of superficial tumors, the presence of large blood vessels transmitting through the detected region and carrying blood at the systemic temperature can be an important source of temperature non-uniformity and possible misdiagnose. However, such important issue in non-invasive thermal diagnostics has received few attentions up to now. In this study, two typical vascular models are applied to probe into the impact of large blood vessels on the skin temperature profiles during applying both steady-state and dynamic infrared thermography. The results indicate that the large vessels close to the disease region can produce significant effects to the thermal images at skin surface, and that without carefully considering the impact of large vessels, both false negative and false positive diagnoses may be made. This study is expected to help realize a more accurate and quantitative non-invasive diagnoses using infrared thermography in the presence of large vessels.

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Nelson, David A., Saeed I. Latif, Chad Austin, and Jeremy Chatham. "Feasibility of Using a Printed Microstrip Antenna in Evaluation of Peripheral Microcirculation." In 2018 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/dmd2018-6912.

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Peripheral Artery Disease (PAD) is a widespread and often undiagnosed condition associated with increased incidence of serious cardiovascular events. Current diagnostic tests for PAD may not be adequate for screening the large at-risk population. A new skin blood flow measurement technique using RF heating in the millimeter wave band, with simultaneous surface temperature measurement offers a potential method for screening individuals at risk for PAD quickly and easily. The feasibility of a transducer design incorporating a microstrip antenna and one or more infrared temperature sensors was evaluated in vitro, using a phantom skin material and a custom flow chamber. Results demonstrate the ability to heat the unperfused phantom by up to 7°C in less than 60 s, depending on antenna separation distance from the target surface. At a distance of 2 mm, preliminary results indicate the rate of temperature increase is sensitive to flowrate. These results suggest a possible method for noninvasive screening of individuals for PAD that is quick, easy and inexpensive.

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Krasavina, E. K., I. V. Yatsyna, and I. Y. Zhadan. "SCREENING CYTOCHEMICAL METHODS IN THE DIAGNOSIS OF PROFESSIONAL AND PROFESSIONALLY CAUSED SKIN PATHOLOGY." In The 16th «OCCUPATION and HEALTH» Russian National Congress with International Participation (OHRNC-2021). FSBSI “IRIOH”, 2021. http://dx.doi.org/10.31089/978-5-6042929-2-1-2021-1-280-284.

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Abstract: Introduction: Skin diseases of professional etiology remain to this day an urgent problem, despite the low levels of morbidity according to official statistics, due to the high medical and social significance of this pathology. For early diagnosis of occupational and occupational-related skin pathology, it is necessary to investigate laboratory markers that correlate with this pathology. In this regard, a promising direction is to study the activity indicators of hydrolytic enzymes of neutrophils: alkaline and acid phosphatases, the level of myeloperoxidase. Objective: to study and evaluate the effectiveness of cytochemical methods for diagnosing the reactivity of the body in workers exposed to a chemical factor in the workplace. Research methods: hygienic assessment of working conditions of woodworking workers, assessment of the health status and cytochemical parameters of workers. Analysis of the obtained data by methods of mathematical statistics. Results: A hygienic assessment of working conditions and an inspection, with a complex of cytochemical studies, of 148 employees of the chipboard manufacturing enterprise were carried out. The leading factor affecting the body of workers is chemical. A direct strong correlation (r=0.7) was established between the level of dermatological morbidity and the indicators of air pollution of the working area with formaldehyde. Skin pathology was detected in 32.4% of the examined workers. At the same time, the indicators of cytochemical activity in the examined group correlated with the degree of severity of the skin process. Conclusions: Cytochemical indicators in combination with other clinical and diagnostic studies allow us to assess the risk of developing professional and professionally caused skin pathology, which allows us to use them for early diagnosis, and thus contribute to the preservation of labor potential and social adaptation of workers exposed to occupational hazards.

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Finnegan, Jason, Bridget Peterkin, Hee-Chan Han, Jennifer M. Yentes, Stephen I. Rennard, and Eric J. Markvicka. "Wireless, Battery Free Wearable Electronic Nose." In 2022 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2022. http://dx.doi.org/10.1115/dmd2022-1038.

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Abstract Volatile organic compounds (VOCs) are excreted through the skin or exhaled breath. They are end products of human metabolism, metabolism of gut microflora, and ingested or inhaled substances. VOCs can be noninvasively sampled and could be a useful marker for disease. However, medical diagnostics rarely considers the VOCs that are expelled from the body. Here, we introduce a miniature, low-cost, and battery-free electronic nose (e-nose) sensor for passively identifying chemical patterns that are excreted from the human skin or exhaled breath. The platform is composed of an array of conductive polymer filaments created with a two-layer system of multi-walled carbon nanotubes and four different, solution processable polymers. The “breathprint” signature–consisting of the resistance of each filament–can be read from the sensor using a near-field communication-enabled device, such as a smartphone. The e-nose sensor contains a system on a chip with near-field communication (NFC) functionality and a radio frequency antenna to harvest power. The sensor was tested against six common VOCs that are released from the human body.

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Eze, R., and Y. Hassebo. "Monte Carlo Simulation of Backscatter Signals Through Thin Scattering Layers for Biomedical Applications." In ASME 2014 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/imece2014-36352.

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Monte Carlo simulation of photon transport is formulated to solve transient radiative transfer equation through thin multilayered scattering-absorbing media with inhomogeneous properties. Though thin layers might seem to be geometrically insignificant, contribution of their radiative properties is relevant in predicting the behavior of most bioengineering, biomedical and space applications. Most traditional Monte Carlo models often fail to capture the presence of thin layers and account for its radiative properties. If the Monte Carlo model is implemented without unique features then the results of the simulation would show incorrect effect of thin layers since the path length of most photons would be significantly larger than the layer thickness and the evaluated photon travel path length would simply not feel the existence of the layer. Numerical and algorithmic features for computation of radiation transport through thin scattering and absorbing layers using the traditional Monte Carlo and an enhanced Monte Carlo model with features specifically developed for thin layers is presented and implemented for the analysis of backscattered radiation. It is observed that while Monte Carlo without special features defines the radiative effect of the layers, the refined technique indicates that layers have a great impact on the backscattered light, especially if the layer properties are distinctly different from those of the contiguous layers. The results have significant implications in the study of diagnostic applications of laser in biomedical applications since backscattered light is one of the non-invasive techniques available for detection of diseases and complements other known methods. Analyses of backscattered signals have also found use in the noninvasive methods of medical use especially in skin diagnostics.

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