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Dissertations / Theses on the topic 'Diaphragmatic hernia'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Rajatapiti, Prapapan. "Pulmonary development in congenital diaphragmatic hernia." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2007. http://hdl.handle.net/1765/10705.

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Klaassens, Merel. "Genetic factors in the etiology of longenital diaphragmatic hernia." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2007. http://hdl.handle.net/1765/10297.

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3

Russell, Meaghan Kathleen. "Molecular mechanisms of diaphragm development: implications for congenital diaphragmatic hernia." Thesis, Boston University, 2012. https://hdl.handle.net/2144/32051.

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Thesis (Ph.D.)--Boston University<br>PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Congenital abnormalities of the diaphragm, specifically congenital diaphragmatic hernia (CDH), affect 1 in 3,000 live births and are associated with substantial morbidity and mortality. Evidence in humans and

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Lin, Frank C., Jamie S. Lin, Samuel Kim, and Jonathan R. Walker. "A rare diaphragmatic ureteral herniation case report: endoscopic and open reconstructive management." BIOMED CENTRAL LTD, 2017. http://hdl.handle.net/10150/624352.

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Background: Ureteral herniations are a rare occurrence, generally found incidentally on cross sectional imaging or during surgical intervention for unrelated processes. Several locations of ureteral herniations can occur including the inguinal, femoral, sciatic, obturator, and thoracic regions. While few reports of ureteral hernias are reported in the literature overall, the vast majority of those reported are inguinoscrotal herniations found during evaluation and treatment of inguinal hernias. Pelvic outlet ureteral herniations intrinsically are more common secondary to their dependent locati

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Ramakrishnan, Rema. "Ambient Ozone and Cadmium as Risk Factors For Congenital Diaphragmatic Hernia." Scholar Commons, 2017. https://scholarcommons.usf.edu/etd/7439.

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Congenital diaphragmatic hernia (CDH) results from a defect in the diaphragm through which abdominal contents enter the thorax displacing the heart and the lungs. This causes lung hypoplasia and varying degrees of pulmonary hypertension resulting in high rates of morbidity and mortality. Though CDH has a prevalence rate of 2.61 per 10,000 live births it is an expensive birth defect with an estimated annual cost of nearly $250 million for all CDH survivors. Maternal exposure to air pollutants have not been studied as risk factors for CDH in humans. Ambient ozone has been found to be risk factor

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Baracho, Ana Sofia Esperança da Palma. "Hérnias diafragmáticas congénitas : revisão bibliográfica a propósito de três casos clínicos." Master's thesis, Universidade Técnica de Lisboa. Faculdade de Medicina Veterinária, 2011. http://hdl.handle.net/10400.5/3773.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>Entende-se como hérnia diafragmática (HD) um deslocamento de órgãos abdominais para a cavidade torácica (CT) através de uma solução de continuidade anómala do diafragma. Pode ser adquirida ou congénita, compreendendo este grupo as hérnias diafragmáticas peritoneopericárdicas (HDPP), as hérnias diafragmáticas pleuroperitoneais (HDPlP) e as hérnias do hiato (HH), sendo as primeiras as mais frequentes. A etiologia destas alterações não está totalmente esclarecida, apontando as teorias mais defendidas uma lesão embrionária ou uma a

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Jesudason, Edwin C. "Embryonic lung development in an experimental model of congenital diaphragmatic hernia (CDH)." Thesis, University of Liverpool, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343715.

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8

Zussman, Matthew E. M. D. "Pulmonary Vascular Resistance in Repaired Congenital Diaphragmatic Hernia vs. Age Matched Controls." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1335462514.

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9

Barth, Juliane. "Betrachtung der pränatalen Diagnostik, der peri- und postnatalen Therapie sowie der physischen und mentalen Entwicklung bei Patienten mit kongenitalen Zwerchfelldefekten im Zeitraum von 1991 bis 2006." Doctoral thesis, Universitätsbibliothek Leipzig, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-64921.

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Bei kongenitalen Zwerchfelldefekten kommt es zu einer Herniation von abdominellen Organen in den Thorax. Es resultieren eine Lungenhypoplasie und eine pulmonale Hypertonie, die die hohe Mortalität und Morbidität bestimmen. In dieser Studie wurden prä-, peri- und postnatale Parameter von Patienten mit kongenitalen Zwerchfelldefekten retrospektiv betrachtet und auf eine mögliche Prädiktion für das Outcome sowie auf therapeutische Qualitätsänderungen überprüft. Im prospektiven Teil wurde die weitere Entwicklung der Kinder nach dem stationären Aufenthalt eruiert. Statistisch signifikante Unterschi

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10

Cabral, Marta Filipa Almeida. "Relatório de clínica de animais de companhia: hérnia diafragmática peritoneo-pericárdica." Master's thesis, Universidade de Évora, 2014. http://hdl.handle.net/10174/13992.

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Este relatório insere-se no âmbito do Mestrado Integrado em Medicina Veterinária da Universidade de Évora e é constituído por duas partes fundamentais. A primeira parte do relatório engloba todas as atividades desenvolvidas e casuística observada durante o estágio curricular realizado nas instalações veterinárias Montenegro, referentes à clínica de animais de companhia. A segunda parte consiste na revisão bibliográfica de hérnia diafragmática peritoneo-pericárdica. Esta hérnia é considerada a malformação congénita pericárdica e diafragmática mais comum em cães e gatos, apresentando um prognóst

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11

Wild, Benjamin. "Elevated Matrix Enzyme Activity Is Associated with the Progression of Pulmonary Vascular Disease In the Nitrofen Model of Congenital Diaphragmatic Hernia." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32429.

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Pulmonary vascular disease (PVD) and lung hypoplasia (LH) are the two main causes of mortality and morbidity in patients with congenital diaphragmatic hernia (CDH). Previous studies have shown that remodeling of the extracellular matrix (ECM) by elastase and matrix metalloproteinase (MMP) enzymes, concomitant with smooth muscle cell (SMC) proliferation and deposition of ECM proteins and growth factors, leads to primary pulmonary hypertension (PH) and that blockade of this pathway results in disease reversal. The aim of our study is to determine whether a similar pathway is induced in the PVD a

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12

O'Toole, Stuart John. "The pulmonary surfactant system in congenital diaphragmatic hernia and the influence of fetal surgery on its development." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312035.

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13

Khan, Nasir. "Effects of tracheal occlusion (TO) on sonic-hedgehog (Shh) expression in animal models of congenital diaphragmatic hernia (CDH)." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=98737.

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Background. The mechanism by which tracheal occlusion (TO) induces lung growth is unknown. The sonic hedgehog (Shh) is a signaling protein essential for bronchial branching and lung maturation in rats. Shh expression is delayed in nitrofen-induced congenital diaphragmatic hernia (CDH). The aim of this study was to see if TO could up-regulate Shh expression in CDH.<br>Methods. To create CDH in fetal rats, time-dated pregnant rats were gavaged 100 mg of nitrofen on day 9.5 post-conception. TO was performed on day 19 of gestation (term=22 days). Animals were sacrificed on day 20 and 21. Lung grow

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14

Delabaere, Amélie. "Rétinoïdes en intra-trachéal et occlusion de trachée dans le traitement anténatal de la hernie diaphragmatique congénitale sur un modèle lapin." Thesis, Université Clermont Auvergne‎ (2017-2020), 2017. http://www.theses.fr/2017CLFAS024.

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La hernie de coupole diaphragmatique (HCD) congénitale est une anomalie de développement du diaphragme survenant au cours de l’embryogénèse, qui laisse persister une communication entre les cavités péritonéale et pleurale. Dans sa forme la plus fréquente, elle concerne la région postérolatérale de la coupole diaphragmatique gauche (85% des cas). Elle rend possible la migration intrathoracique de viscères abdominaux et nuit à l’efficacité inspiratoire des mouvements diaphragmatiques foetaux. Il en résulte une compression des viscères thoraciques qui se solde essentiellement par une hypoplasie p

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Vuckovic, Aline. "Prenatal modulation of the developing lung in congenital diaphragmatic hernia: functional, morphological, and biological consequences for the neonatal lung." Doctoral thesis, Universite Libre de Bruxelles, 2016. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/228906.

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INTRODUCTION. Congenital diaphragmatic hernia (CDH) combines a congenital malformation of the diaphragm with lung hypoplasia, leading to severe respiratory distress and intractable pulmonary hypertension of the newborn. Despite advances in prenatal diagnosis and neonatal intensive care, CDH is associated with high mortality and devastating morbidities. In the absence of curative treatment, numerous prenatal therapies have been used experimentally with varying success. So far, only fetal tracheal occlusion has been tested in clinical trials, but the consequences for the human lung are poorly kn

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16

Bratu, Ioana. "Long growth, structural remodeling, surfactant levels, and lung function after reversible fetal lamb tracheal occlusion in congenital diaphragmatic hernia." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33383.

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The effects of reversible fetal tracheal occlusion (TO), and antenatal glucocorticoids on lung growth, structure, surfactant levels, and function were assessed in a lamb hypoplastic lung model of congenital diaphragmatic hernia (CDH). CDH, CDH+TO, CDH+TO+release of the tracheal occlusion one week before delivery (TR), and unoperated twin controls were compared. TO+/-TR partially normalized the hypoplastic lungs of CDH: they accelerated growth of both lungs and led to structural maturity. Only TO thinned the medial area of small pulmonary arteries closer to control values. Despite TO, TR, and g

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17

Schneider, Anne. "Caractérisation et optimisation de biomatériaux pour le traitement de la hernie diaphragmatique congénitale à large défect." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAE028.

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Les prothèses diaphragmatiques en ePTFE utilisées dans la hernie diaphragmatique congénitale à large défect ont une faible étirabilité, ce qui entrainera des récidives herniaires au cours de la croissance de l’enfant. En effet, l’analyse en imagerie montre que la surface du diaphragme grandit de 4-5 fois jusqu’à l’adolescence. De plus, les mesures de rigidité des surfaces de prothèses explantés, montrent l’influence des contraintes mécaniques appliquées sur la structure des matrices extracellulaires néoformées. Afin de favoriser l’intégration tissulaire du ePTFE, nous avons testé un moyen de f

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18

Baird, Robert 1976. "Morphologic and molecular investigation of pulmonary branching in the Nitrofen-rat model of congenital diaphragmatic hernia with or without tracheal occlusion." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=97898.

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Fetal tracheal occlusion (TO) has been investigated as a treatment option for lung hypoplasia secondary to Congenital Diaphragmatic Hernia (CDH). While it has been shown to promote larger lungs, it is unclear whether TO stimulates mature lung growth or simply induces alveolarization without concomitant bronchial development, a distinction with important clinical implications. We employed the Nitrofen rat model of CDH to investigate the effect of TO on fetal lung branching through morphometric examination, lung casting, lung histology and comparison of two molecular markers involved in lung gro

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Allan, Douglas Watt. "Prenatal development of the rat phrenic nerve and diaphragm, basic embryology, role of PSA-NCAM and the pathogenesis of congenital diaphragmatic hernia." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0009/NQ59925.pdf.

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20

Sgrò, Alberto. "Tissue engineering for the surgical tratment of muscle defects: application on animal model of congenital diaphragmatic hernia and skeletal volume muscle loss." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3426684.

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Background. Repair of skeletal muscle loss due to trauma, surgical resection or malformations represent a challenge for clinicians. Several attempts to create a bioscaffold to substitute skeletal muscle have been done but no satisfying results were obtained due to lack in regeneration process and functionality of repaired tissue. Some studies on tissue engineering investigated the application of decellularized extracellular matrix (ECM) derived from skeletal muscle observing positive effect towards regeneration. It is becoming relevant the role of tissue-specificity in the field of tissue engi

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Lacreuse, Isabelle. "Contributions à l’amélioration et l’élaboration de biomateriaux dédiés à la hernie diaphragmatique congénitale." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAE014.

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La hernie diaphragmatique congénitale se définit par la présence d’un défect postérolatéral du muscle diaphragmatique. Sa prise en charge est chirurgicale par interposition d’une prothèse dans les formes les plus graves. La prothèse idéale n’existe pas et nous l’avons prouvé par l’analyse d’explants montrant une colonisation non satisfaisante. De même les tests mécaniques réalisés sur les prothèses les plus couramment utilisées montrent des propriétés inadaptées dans cette indication. Nous avons pu développer deux axes prometteurs :- La fonctionnalisation par la polydopamine du Tétrafluoroethy

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22

Thompson, Sophie Marie. "Abnormalities in heparan sulfate structure and epitope distribution in hypoplastic lungs from a teratogenic rat model of congenital diaphragmatic hernia; possible contribution to pathogenesis." Thesis, University of Liverpool, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494166.

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The complex polysaccharide, heparan sulfate (HS), regulates airway development by controlling cell-cell and cell-matrix communication via interactions with a vast number of proteins e.g., growth factors. Loss of HS biosynthetic enzymes in Drosophila and mice illustrates the requirement for HS in airway morphogenesis and results in a major disruption in airway branching, and in the mouse, neonatal death. However, knowledge of HS structure within the lung is limited. HS antibodies produced by 'phage display provide a new tool for analysing HS in situ and have allowed specific HS structures to be

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Grushka, Jeremy. "Morphologic and molecular investgations of pulmonary branching in fetal lung explants from the nitrofen-rat model of congenital diaphragmatic hernia with or without tracheal occlusion." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=96795.

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Fetal tracheal occlusion (TO) has been investigated as a treatment option for lung hypoplasia secondary to congenital diaphragmatic hernia (CDH). TO has been shown to accelerate lung growth but its effect on bronchial branching is unknown. In this study we characterized the effects of in vitro TO on bronchial branch development in fetal lung explants derived from the Nitrofen rat model of CDH and on the expression of four molecular markers involved in lung development (FGF10, SHH, VEGF, LGL1). Nitrofen administration induced lung hypoplasia as shown by decreased airway branching in fetal lung

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Curtinhal, Inês Tomás. "Malformações congénitas associadas a hérnia peritoneopericárdica : estudo retrospetivo." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2021. http://hdl.handle.net/10400.5/21721.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>A hérnia diafragmática peritoneopericárdica (HDPP) ocorre devido a uma malformação congénita do diafragma, podendo ser acompanhada de outras malformações congénitas, nomeadamente hérnia abdominal cranioventral, malformações esternais e malformações cardíacas. O prognóstico de animais diagnosticados com HDPP e com malformações congénitas associadas é, geralmente, bom. No entanto, quando na presença de malformações congénitas cardíacas, o prognóstico torna-se grave ou reservado. O tratamento de uma HDPP inclui métodos cirúrgicos ou con

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25

Giné, Prades Carles. "Efectos en el desarrollo pulmonar de la oclusión traqueal precoz como terapia fetal de la hipoplasia pulmonar en la hernia diafragmática congénita del feto ovino." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/457346.

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Introducción: La oclusión traqueal mediante la colocación fetoscópica de un balón endotraqueal a las 26-29 semanas de gestación constituye el tratamiento estándar de los casos graves de hernia diafragmática congénita (CDH) diagnosticados prenatalmente. Sin embargo, algunos pacientes presentan indicadores prenatales de hipoplasia pulmonar extrema y, a pesar del tratamiento fetoscópico, su tasa de supervivencia es cercana al 0%. Algunos estudios clínicos abogan por una oclusión traqueal en estadíos más precoces del desarrollo embrionario en este tipo de pacientes considerando que los pulmones

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Alvarez, Fallas Mario Enrique. "Diaphragm derived acellular matrix as multistep study: from development to characterization using in vitro and in vivo strategies." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424392.

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Abstract Introduction The demand for organ transplantation has rapidly increased during the past decades, thus requiring the development of a new interdisciplinary field, aimed at supplying this demand. Branching from regenerative medicine, the combination of elements usually applied separately for same or other purposes, was named Tissue Engineering (TE). Precisely, the components combined in TE constitute the so-called TE triad, are i) cells (derived from cell therapy), ii) scaffolding material (derived from material science) and iii) molecular signals (mainly derived from molecular bi

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27

Butter, Andreana. "Lung growth and lung function after a) fetal lamb tracheal occlusion and exogenous surfactant at birth in congenital diaphragmatic hernia and b) selective perfluorocarbon distention in healthy newborn piglets." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33073.

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This study sought to maximize prenatal and postnatal interventions in order to accelerate lung growth and improve lung function in two animal models. Prenatal interventions consisted of fetal tracheal occlusion (TO), antenatal glucocorticoids and exogenous surfactant at birth (SURF) in an ovine model of congenital diaphragmatic hernia (CDH). CDH, CDH+TO, CDH+SURF, CDH+TO+SURF and unoperated twin control lambs were compared. Prenatal growth of both lungs was accelerated after fetal TO. Prophylactic surfactant did not improve gas exchange or ventilation but did increase lung compliance over 8 ho

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Makanga, Martine. "Pathobiologie de la hernie diaphragmatique congénitale expérimentale induite par l'exposition au nitrofène chez le rat." Doctoral thesis, Universite Libre de Bruxelles, 2015. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209093.

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Trevisan, Caterina. "Decellularised matrix and stem cells to rebuild damaged muscle: an innovative approach of regenerative medicine." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3424881.

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Skeletal muscle is an essential tissue for several vital functions. It displays an intrinsic regenerative ability in case of injury, thanks to the activation of satellite cells (SCs), the adult skeletal muscle stem cells. In presence of large defects, the renewing capacities of skeletal muscle are compromised. In such situations regenerative medicine may be a promising solution. This project is focused on a neonatal pathology known as congenital diaphragmatic hernia (CDH), in which the diaphragm fails to close during gestation. CDH is a severe anomaly with an incidence of 1 on 2,500-3,000 new-

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Barbosa, Bruna Maria Lopes. "Estudo da prematuridade em fetos com hérnia diafragmática congênita: avaliação de fatores de predição." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-24032016-121532/.

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INTRODUÇÃO: A hérnia diafragmática congênita é uma malformação fetal potencialmente grave, que está associada a alta mortalidade. Sabe-se que a prematuridade é um significante fator de risco para morbidade e mortalidade neonatal na maioria das doenças, porém sua relação com a hérnia diafragmática congênita pouco tem sido descrita. O que se tem observado nos estudos nesses fetos é que a incidência de prematuridade é maior que na população em geral OBJETIVOS: Avaliar a incidência de prematuridade nos fetos com hérnia diafragmática congênita e seus possíveis fatores de predição. MÉTODOS: Estudo d

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Cleal, Louise Kathleen. "The origins and heterogeneity of adipose tissue : investigating the role of the Wilms' tumour 1 (Wt1) gene." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/29568.

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Largely as a consequence of the ongoing obesity epidemic, research into adipose tissue biology has increased substantially in recent years. Worldwide, the number of people classed as overweight or obese is growing, and this represents a major public health concern. Adipose tissue is broadly divided into two types; white and brown. Whilst white adipose tissue (WAT) functions to store and mobilise triglycerides, brown adipose tissue burns chemical energy to generate heat. WAT is further divided into visceral “bad” fat and subcutaneous “good” fat depots, and it is an increase in the former that i

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Fromm, Frederik Felipe [Verfasser]. "Fetoscopic abdominal decompression of congenital diaphragmatic hernia – a proof of concept study and stereological analysis based on morphological pulmonary changes in an ovine animal model : Pilotstudie über die abdominelle Dekompression einer Zwerchfellhernie durch iatrogene Gastroschisis -Teschnische Machbarkeit und Lungenveränderungen am fetalen Schafmodell / Frederik Felipe Fromm." Hamburg : Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky, 2019. http://d-nb.info/1225711584/34.

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Heling, Kai-Sven. "Stellenwert der sonographischen Lungenbiometrie in der pränatalen Vorhersage einer Lungenhypoplasie." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2003. http://dx.doi.org/10.18452/13890.

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Die vorliegende Arbeit beschäftigt sich mit der Anwendung der sonographischen Lungenbiometrie in der Pränataldiagnostik zur Erkennung einer Lungenhypoplasie. Im ersten Abschnitt wurden anhand definierter Messebenen Normwerte für verschiedene biometrische Parameter (Durchmesser, Länge) der fetalen Lunge erstellt. Im zweiten Abschnitt wurde diese Meßmethode mit Hilfe eines Hochrisikokollektivs (N=29) für die intrauterine Entwicklung einer Lungenhypoplasie hinsichtlich ihrer prognostischen Aussagekraft untersucht. Es konnte nur eine sehr geringe Sensitivität und Spezifität der verschiedenen M

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Le, Duc Kévin. "Physiologie des échanges gazeux et de l'hémodynamique transplacentaire lors d'une réanimation à cordon intact : modèle expérimental d'agneau porteur de hernie diaphragmatique." Electronic Thesis or Diss., Université de Lille (2022-....), 2024. http://www.theses.fr/2024ULILS079.

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La naissance est une période à risque qui met en jeux de multiples mécanismes qui permettent une transition de la vie fœtale et la vie extra-utérine. Chaque année, dans les conséquences d'une mauvaise adaptation à la vie extra-utérine et la persistance de résistances vasculaires pulmonaires trop élevées, 1 million de nouveau-né décède dans les 24 premières heures de vie. Dix pourcents des nouveau-nés requièrent une assistance médicale en salle de naissance. Le clampage du cordon ombilical retardé entre 60 et 180 secondes après la naissance est désormais recommandé pour toutes les situations où

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Baptista, Maria João Ribeiro Leite. "Perinatal cardiac function in congenital diaphragmatic hernia." Doctoral thesis, 2008. http://hdl.handle.net/1822/7706.

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Tese de Doutoramento Ciências da Saúde – Ciências Biológicas e Biomédicas<br>Congenital diaphragmatic hernia (CDH) is a congenital condition with variable illness severity that usually requires complex and multidisciplinary care. The physiologic consequences of this defect may be mild and minimally symptomatic at birth, but almost half of CDH infants present with severe forms of the disease, with poor outcome and extremely high mortality, despite aggressive treatment even in experienced teams with sophisticated management protocols. Morbidity and mortality associated with CDH is largely

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Bovino, Scott Anthony. "The evolution and treatment of congenital diaphragmatic hernias in neonates." Thesis, 2017. https://hdl.handle.net/2144/23760.

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Congenital diaphragmatic hernia (CDH) is a potentially fatal condition found in neonates where embryological defects in the diaphragm negatively impact fetal maturation and growth. The defect allows contents below the diaphragm to potentially migrate into the thoracic cavity during development, which could lead to secondary complication including pulmonary hypertension and left ventricular hypoplasia. CDH tends to have a high neonate mortality rate in congruence with the severity of the condition. Several risk factors for CDH include accompanying chromosomal abnormalities and the anatomical po

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Kholdebarin, Ramin. "The role of microRNA-200b in pulmonary hypoplasia associated with congenital diaphragmatic hernia." 2012. http://hdl.handle.net/1993/14170.

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Congenital diaphragmatic hernia (CDH) is a developmental defect of the diaphragm that is associated with pulmonary hypoplasia. MicroRNAs are small RNAs that regulate protein expression. In this project the role of micro-RNA 200b (miR-200b) in CDH was explored through in situ hybridization. In human tissue, CDH was associated with increased miR-200b expression. In rats, nitrofen-induced CDH was associated with decreased miR-200b expression. In mesenchymal tissue, miR-200b expression was high in undifferentiated splanchnic mesenchyme. Its expression dropped with increasing gestational age and in

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Morais, Catarina Granjo de Oliveira e. Ventura. "Predictors of prognosis in neonates with Congenital Diaphragmatic Hernia: experience of 12 years." Master's thesis, 2016. https://repositorio-aberto.up.pt/handle/10216/88598.

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Morais, Catarina Granjo de Oliveira e. Ventura. "Predictors of prognosis in neonates with Congenital Diaphragmatic Hernia: experience of 12 years." Dissertação, 2016. https://repositorio-aberto.up.pt/handle/10216/88598.

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渡部, 百合子, and Yuriko Watanabe. "Amniotic lamellar body count and congenital diaphragmatic hernia in humans and in a rat model." Thesis, 2014. http://hdl.handle.net/2237/20384.

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MASSOLO, ANNA CLAUDIA. "Pulmonary hypertension and cardiac function in congenital diaphragmatic hernia: relationship to disease severity and outcomes." Doctoral thesis, 2019. http://hdl.handle.net/11573/1215973.

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Abstract Objective To assess patterns of postnatal biventricular function and their relationship to prenatal and postnatal markers of disease severity in infants with congenital diaphragmatic hernia (CDH). To investigate clusters of micro RNA as 17-92 expressed in pulmonary hypoplasia in patients with CDH. Study Design Observational case-control study of cardiac function in infants with CDH in the first 5 days of life. Systolic and diastolic function in the right (RV) and left (LV) ventricles were assessed using speckle tracking-derived global strain and tissue Doppler imaging of myo

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Visser, Robin. "MiRacles for babies with pulmonary hypoplasia: the effects of miR-10a and miR-200b on lung development." 2016. http://hdl.handle.net/1993/31060.

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INTRODUCTION: Pulmonary hypoplasia causes high morbidity and mortality in congenital diaphragmatic hernia (CDH) patients. MiR-10a and miR-200b are overexpressed in human CDH lungs. We aimed to define their roles in lung development. METHODS: We profiled miR-10a expression with RT-qPCR and in situ hybridization using a nitrofen rat model for CDH. The effects of miR-10a on airway branching were evaluated in lung explants. MiR-200b’s role in airway branching was assessed in miR-200b knockout lung explants. Crossing miR-200b knockout mice with CFP-E-Cadherin was used to evaluate miR-200b’s effects

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Lusney, Nadine. "Stories of Early Experiences of Nursing Care in the Neonatal Intensive Care Unit from Parents' Whose Infants are born with Congenital Diaphragmatic Hernia." Thesis, 2014. http://hdl.handle.net/1828/5229.

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The birth of a child diagnosed with congenital diaphragmatic hernia (CDH) involves significant intensive care at the beginning of life and the need for surgery. Parents’ experiences during the acute phase of hospitalization for a critically ill infant not born premature is currently limited in the literature; in particular, there is no literature describing parents’ experiences of nursing care for having a infant with CDH in the Neonatal Intensive Care Unit (NICU). Using narrative inquiry this study explores stories of parents’ early experiences of nursing care in the NICU for an infant born w

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Barth, Juliane. "Betrachtung der pränatalen Diagnostik, der peri- und postnatalen Therapie sowie der physischen und mentalen Entwicklung bei Patienten mit kongenitalen Zwerchfelldefekten im Zeitraum von 1991 bis 2006: Betrachtung der pränatalen Diagnostik, der peri- und postnatalenTherapie sowie der physischen und mentalen Entwicklungbei Patienten mit kongenitalen Zwerchfelldefekten imZeitraum von 1991 bis 2006." Doctoral thesis, 2010. https://ul.qucosa.de/id/qucosa%3A11123.

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Bei kongenitalen Zwerchfelldefekten kommt es zu einer Herniation von abdominellen Organen in den Thorax. Es resultieren eine Lungenhypoplasie und eine pulmonale Hypertonie, die die hohe Mortalität und Morbidität bestimmen. In dieser Studie wurden prä-, peri- und postnatale Parameter von Patienten mit kongenitalen Zwerchfelldefekten retrospektiv betrachtet und auf eine mögliche Prädiktion für das Outcome sowie auf therapeutische Qualitätsänderungen überprüft. Im prospektiven Teil wurde die weitere Entwicklung der Kinder nach dem stationären Aufenthalt eruiert. Statistisch signifikante Unterschi

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Savvas, Eleftherios George [Verfasser]. "Effects of prenatal glucocorticoids and postnatal nitric oxide inhalation on the survival and lung maturation of newborn rats with congenital diaphragmatic hernia / submitted by Eleftherios George Savvas." 2008. http://d-nb.info/990166015/34.

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Frazão, Laura Passos Morgado Franco. "The decellularized human chorion membrane as a new biomaterial: characterization and applications." Doctoral thesis, 2021. http://hdl.handle.net/1822/75636.

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Tese de doutoramento em Engenharia de Tecidos, Medicina Regenerativa e Células Estaminais<br>Decellularized inner body membranes have been studied for several different tissue engineering applications. However, its availability is limited, except in the case of placental membranes. Placental membranes are composed by the amnion membrane and the chorion membrane. While the human amnion membrane has been widely studied for tissue engineering and regenerative medicine applications, the human chorion membrane was poorly studied, only being subject of research interest in recent years. Envisi

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Rounová, Petra. "Vliv velikosti defektu a operační techniky na dlouhodobou morbiditu dětí s vrozenou brániční kýlou." Doctoral thesis, 2013. http://www.nusl.cz/ntk/nusl-328210.

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52 8 Summary The influence of defect size and surgical technique on the long-term morbidity of children with congenital diaphragmatic hernia Objective: The aim of this study is to evaluate the effects of diaphragm reconstruction using a synthetic non-absorbable patch from polytetrafluoroethylene (PTFE, Gore-Tex) and primary repair of diaphragm defects on the long-term morbidity in children after surgery of congenital diaphragmatic hernia (CDH), with a primary interest in the influence of these techniques on the occurrence of skeletal deformities and the development of pulmonary functions. One

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