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1

Khamrin, Pattara, Natthawan Chaimongkol, Nattika Nantachit, Shoko Okitsu, Hiroshi Ushijima, and Niwat Maneekarn. "Saffold Cardioviruses in Children with Diarrhea, Thailand." Emerging Infectious Diseases 17, no. 6 (June 2011): 1150–52. http://dx.doi.org/10.3201/eid1706.101983.

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Kumthip, Kattareeya, Pattara Khamrin, Arpaporn Yodmeeklin, and Niwat Maneekarn. "Salivirus infection in children with diarrhea, Thailand." Archives of Virology 162, no. 9 (June 2, 2017): 2839–41. http://dx.doi.org/10.1007/s00705-017-3435-9.

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PADUNGTOD, PAWIN, and JOHN B. KANEENE. "Campylobacter in Food Animals and Humans in Northern Thailand." Journal of Food Protection 68, no. 12 (December 1, 2005): 2519–26. http://dx.doi.org/10.4315/0362-028x-68.12.2519.

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Cross-sectional, longitudinal, and case-control studies were conducted to describe the epidemiology of Campylobacter in chickens, swine, dairy cows, farm workers, nonfarm residents, and children with diarrhea. Samples were collected in Chiang Mai and Lamphung provinces of northern Thailand from 2000 through 2003. A total of 2,360 samples were processed. Results from the cross-sectional study indicated that the prevalences of Campylobacter in chickens at the farm, slaughterhouse, and market were 64, 38, and 47%, respectively. In swine, the prevalences at the farm, slaughterhouse, and market were 73, 69, and 23%, respectively. Campylobacter prevalence was 14% in dairy cows and 5% in raw milk. The prevalence of Campylobacter on farms was lower in environmental samples than in samples collected from live animals. No Campylobacter isolates were obtained from healthy nonfarm residents, but isolates were obtained from 5 and 18% of farm workers and children with diarrhea, respectively. The prevalence of Campylobacter in pigs in the longitudinal study was 61% at the farm, 46% at the slaughterhouse, and 33% at the market. The majority of Campylobacter isolates from chickens (52%), swine (98%), and farm workers (66%) were Campylobacter coli, whereas the majority of isolates from dairy cows (63%) and children with diarrhea (62%) were Campylobacter jejuni. Most Campylobacter isolates from diarrheal children had single-strand conformation polymorphism profiles similar to those of isolates from chickens. None of the risk factors for infection in children with diarrhea were significantly associated with the isolation of Campylobacter.
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Chatkaeomorakof, A., P. Echeverria, D. N. Taylor, K. A. Bettelheim, N. R. Blacklow, O. Sethabutr, J. Seriwatana, and J. Kaper. "UeLa Cell-Adherent Escherichia coli in Children with Diarrhea in Thailand." Journal of Infectious Diseases 156, no. 4 (October 1, 1987): 669–72. http://dx.doi.org/10.1093/infdis/156.4.669.

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Sunthadvanich, R., D. Chiewsilp, J. Seriwatana, R. Sakazaki, and P. Echeverria. "Nationwide surveillance program to identify diarrhea-causing Escherichia coli in children in Thailand." Journal of Clinical Microbiology 28, no. 3 (1990): 469–72. http://dx.doi.org/10.1128/jcm.28.3.469-472.1990.

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6

Kumthip, Kattareeya, Pattara Khamrin, Hiroshi Ushijima, Limin Chen, Shilin Li, and Niwat Maneekarn. "Genetic recombination and diversity of sapovirus in pediatric patients with acute gastroenteritis in Thailand, 2010–2018." PeerJ 8 (February 6, 2020): e8520. http://dx.doi.org/10.7717/peerj.8520.

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Background Human sapovirus (SaV) is an etiologic agent of acute gastroenteritis (AGE) in all age groups worldwide. Genetic recombination of SaV has been reported from many countries. So far, none of SaV recombinant strain has been reported from Thailand. This study examined the genetic recombination and genotype diversity of SaV in children hospitalized with AGE in Chiang Mai, Thailand. Methods Stool samples were collected from children suffering from diarrhea who admitted to the hospitals in Chiang Mai, Thailand between 2010 and 2018. SaV was detected by RT-PCR and the polymerase and capsid gene sequences were analysed. Results From a total of 3,057 samples tested, 50 (1.6%) were positive for SaV. Among positive samples, SaV genotype GI.1 was the most predominant genotype (40%; 20/50), followed by GII.1 and GII.5 (each of 16%; 8/50), GI.2 (14%; 7/50), GIV.1 (4%; 2/50), and GI.5 (2%; 1/50). In addition, 4 SaV recombinant strains of GII.1/GII.4 were identified in this study (8%; 4/50). Conclusions The data revealed the genetic diversity of SaV circulating in children with AGE in Chiang Mai, Thailand during 2010 to 2018 and the intragenogroup SaV recombinant strains were reported for the first time in Thailand.
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Pasittungkul, Siripat, Fajar Budi Lestari, Jiratchaya Puenpa, Watchaporn Chuchaona, Nawarat Posuwan, Jira Chansaenroj, John Mauleekoonphairoj, Natthinee Sudhinaraset, Nasamon Wanlapakorn, and Yong Poovorawan. "High prevalence of circulating DS-1-like human rotavirus A and genotype diversity in children with acute gastroenteritis in Thailand from 2016 to 2019." PeerJ 9 (February 26, 2021): e10954. http://dx.doi.org/10.7717/peerj.10954.

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Background Human rotavirus A (RVA) infection is the primary cause of acute gastroenteritis (AGE) in infants and young children worldwide, especially in children under 5 years of age and is a major public health problem causing severe diarrhea in children in Thailand. This study aimed to investigate the prevalence, genotype diversity, and molecular characterization of rotavirus infection circulating in children under 15 years of age diagnosed with AGE in Thailand from January 2016 to December 2019. Methods A total of 2,001 stool samples were collected from children with gastroenteritis (neonates to children <15 years of age) and tested for RVA by real-time polymerase chain reaction (RT-PCR). Amplified products were sequenced and submitted to an online genotyping tool for analysis. Results Overall, 301 (15.0%) stool samples were positive for RVA. RVA occurred most frequently among children aged 0-24 months. The seasonal incidence of rotavirus infection occurred typically in Thailand during the winter months (December-March). The G3P[8] genotype was identified as the most prevalent genotype (33.2%, 100/301), followed by G8P[8] (10.6%, 32/301), G9P[8] (6.3%, 19/301), G2P[4] (6.0%, 18/301), and G1P[6] (5.3%, 16/301). Uncommon G and P combinations such as G9P[4], G2P[8], G3P[4] and G3P[9] were also detected at low frequencies. In terms of genetic backbone, the unusual DS-1-like G3P[8] was the most frequently detected (28.2%, 85/301), and the phylogenetic analysis demonstrated high nucleotide identity with unusual DS-1-like G3P[8] detected in Thailand and several countries. Conclusions A genetic association between RVA isolates from Thailand and other countries ought to be investigated given the local and global dissemination of rotavirus as it is crucial for controlling viral gastroenteritis, and implications for the national vaccination programs.
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8

Rautenberg, Tamlyn, and Ute Zerwes. "The cost utility and budget impact of adjuvant racecadotril for acute diarrhea in children in Thailand." ClinicoEconomics and Outcomes Research Volume 9 (July 2017): 411–22. http://dx.doi.org/10.2147/ceor.s140902.

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9

Rojjanadumrongkul, Kitsakorn, Kattareeya Kumthip, Pattara Khamrin, Nuthapong Ukarapol, Hiroshi Ushijima, and Niwat Maneekarn. "Enterovirus infections in pediatric patients hospitalized with acute gastroenteritis in Chiang Mai, Thailand, 2015–2018." PeerJ 8 (August 17, 2020): e9645. http://dx.doi.org/10.7717/peerj.9645.

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Background Infection with viruses especially rotavirus, norovirus, astrovirus, and adenovirus has been known to be a major cause of acute gastroenteritis in children under 5 years of age globally, particularly in developing countries. Also, some genotypes of enteroviruses (EVs) have been reported to be associated with gastroenteritis. This study is aimed to investigate the prevalence and genotype diversity of EV in children admitted to hospitals with acute gastroenteritis. Methods A total of 1,736 fecal specimens were collected from children hospitalized with diarrhea in Chiang Mai, Thailand from 2015 to 2018. All specimens were tested for the presence of EV by RT-PCR of the 5′ untranslated region. The genotypes of EV were further identified by nucleotide sequencing and phylogenetic analysis of the viral protein 1 (VP1) gene. Results EV was detected in 154 out of 1,736 specimens (8.9%) throughout the study period. The prevalence of EV detected in 2015, 2016, 2017, and 2018 was 7.2%, 9.0%, 11.2%, and 8.6%, respectively. EV was detected all year round with a high prevalence during rainy season in Thailand. Overall, 37 genotypes of EV were identified in this study. Among these, coxsackievirus (CV)-A24 and CV-B5 (7.5% each), and EV-C96 (6.8%) were the common genotypes detected. Conclusion This study demonstrates the prevalence, seasonal distribution, and genotype diversity of EV circulating in children hospitalized with acute gastroenteritis in Chiang Mai, Thailand during the period 2015 to 2018.
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Rochanathimoke, Onwipa, Arthorn Riewpaiboon, Maarten J. Postma, Wirawan Thinyounyong, and Montarat Thavorncharoensap. "Health related quality of life impact from rotavirus diarrhea on children and their family caregivers in Thailand." Expert Review of Pharmacoeconomics & Outcomes Research 18, no. 2 (October 6, 2017): 215–22. http://dx.doi.org/10.1080/14737167.2018.1386561.

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11

Brown, J. E., P. Echeverria, D. N. Taylor, J. Seriwatana, V. Vanapruks, U. Lexomboon, R. N. Neill, and J. W. Newland. "Determination by DNA hybridization of Shiga-like-toxin-producing Escherichia coli in children with diarrhea in Thailand." Journal of Clinical Microbiology 27, no. 2 (1989): 291–94. http://dx.doi.org/10.1128/jcm.27.2.291-294.1989.

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12

Rochanathimoke, O., M. Postma, M. Thavorncharoensap, A. Riewpaiboon, and W. Thinyounyong. "Quality Of Life Of Diarrheal Children And Caregivers In Thailand." Value in Health 17, no. 7 (November 2014): A368—A369. http://dx.doi.org/10.1016/j.jval.2014.08.832.

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13

Arthur, James D., Ladaporn Bodhidatta, Peter Echeverria, Surasith Phuphaisan, and Sakti Paul. "Diarrheal Disease in Cambodian Children at a Camp in Thailand." American Journal of Epidemiology 135, no. 5 (March 1, 1992): 541–51. http://dx.doi.org/10.1093/oxfordjournals.aje.a116321.

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14

Komoto, Satoshi, Ratana Tacharoenmuang, Ratigorn Guntapong, Tomihiko Ide, Kei Haga, Kazuhiko Katayama, Takema Kato, et al. "Emergence and Characterization of Unusual DS-1-Like G1P[8] Rotavirus Strains in Children with Diarrhea in Thailand." PLOS ONE 10, no. 11 (November 5, 2015): e0141739. http://dx.doi.org/10.1371/journal.pone.0141739.

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15

Malasao, Rungnapa, Pattara Khamrin, Kattareeya Kumthip, Hiroshi Ushijima, and Niwat Maneekarn. "Molecular epidemiology and genetic diversity of human parechoviruses in children hospitalized with acute diarrhea in Thailand during 2011-2016." Archives of Virology 164, no. 7 (April 10, 2019): 1743–52. http://dx.doi.org/10.1007/s00705-019-04249-2.

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16

Thongkrajai, Earmpom, Pramote Thongkrajai, John Stoeckel, Somsong Na-nakhon, Busara Karenjanabutr, and Jirapa Sirivatanamethanont. "Socioeconomic and Health Programme Effects Upon the Behavioral Management of Diarrhoeal Disease in Northeast Thailand." Asia Pacific Journal of Public Health 4, no. 1 (January 1990): 45–52. http://dx.doi.org/10.1177/101053959000400108.

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This study investigates the effects of socioeconomic and health programme factors on preventive and curative health behaviors and assesses the impact of preventive health behaviors on the incidence of diarrhoea among children under five years of age. Methodological approaches included focus groups to uncover local definitions of diarrhoeal disease, a baseline survey which collected data on maternal preventive health behaviors for 1, 364 children, and a monitoring system which collected data on the incidence of diarrhoea and on maternal curative behaviors among the same group of children. Results indicate that socioeconomic status and exposure to health programmes showed significant relationships with selected maternal preventive behaviors. Children whose mothers washed their hands before breastfeeding, gave their child food immediately after cooking and warmed foods each time before meals had significantly lower proportions with diarrhoea than children of mothers who did not practice these behaviors, and 70 percent of the children with diarrhoea were exposed to high risk of severe dehydration and related health complications. Implications of these findings for health programmes are discussed.
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17

BLOEM, MARTIN W., MICHEL WEDEL, ROBERT J. EGGER, ANDRIES J. SPEEK, JAAP SCHRIJVER, SASTRI SAOWAKONTHA, and WIL H. P. SCHREURS. "MILD VITAMIN A DEFICIENCY AND RISK OF RESPIRATORY TRACT DISEASES AND DIARRHEA IN PRESCHOOL AND SCHOOL CHILDREN IN NORTHEASTERN THAILAND." American Journal of Epidemiology 131, no. 2 (February 1990): 332–39. http://dx.doi.org/10.1093/oxfordjournals.aje.a115502.

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18

Pham, Ngan Thi Kim, Aksara Thongprachum, Dinh Nguyen Tran, Shuichi Nishimura, Yuko Shimizu-Onda, Quang Duy Trinh, Pattara Khamrin, et al. "Antibiotic Resistance of Campylobacter jejuni and C. coli Isolated from Children with Diarrhea in Thailand and Japan." Japanese Journal of Infectious Diseases 69, no. 1 (2016): 77–79. http://dx.doi.org/10.7883/yoken.jjid.2014.582.

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19

Kjolhede, Chris L., Francisco J. Rosales, and Anne M. Gadomski. "RE: “MILD VITAMIN A DEFICIENCY AND RISK OF RESPIRATORY TRACT DISEASES AND DIARRHEA IN PRESCHOOL AND SCHOOL CHILDREN IN NORTHEASTERN THAILAND”." American Journal of Epidemiology 133, no. 3 (February 1, 1991): 319–20. http://dx.doi.org/10.1093/oxfordjournals.aje.a115880.

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Khamrin, Pattara, Niwat Maneekarn, Aksara Thongprachum, Natthawan Chaimongkol, Shoko Okitsu, and Hiroshi Ushijima. "Emergence of new norovirus variants and genetic heterogeneity of noroviruses and sapoviruses in children admitted to hospital with diarrhea in Thailand." Journal of Medical Virology 82, no. 2 (February 2010): 289–96. http://dx.doi.org/10.1002/jmv.21640.

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Khamrin, Pattara, Supatra Peerakome, Lumduan Wongsawasdi, Supin Tonusin, Penpuck Sornchai, Varunee Maneerat, Chantana Khamwan, et al. "Emergence of human G9 rotavirus with an exceptionally high frequency in children admitted to hospital with diarrhea in Chiang Mai, Thailand." Journal of Medical Virology 78, no. 2 (2005): 273–80. http://dx.doi.org/10.1002/jmv.20536.

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Majeed, Muhammad Mansoor, and Asfa Munir. "Pakistan: country report on children’s environmental health." Reviews on Environmental Health 35, no. 1 (March 26, 2020): 57–63. http://dx.doi.org/10.1515/reveh-2019-0087.

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AbstractPakistan is a developing country with an estimated population of 220 million, and among them 34% are children. Due to the lack of a proper health care system, particularly in rural areas, children are prone to many environmental hazards. This paper reports about the different environmental health issues faced by children in Pakistan and was presented at the Regional Meeting on Children’s Environmental Health at the Chulabhorn Research Institute, Bangkok, Thailand in May 2019. Pakistan is among those countries where polio is still present due to misconceptions, hard-to-reach areas, war zones, political uncertainty, etc. Extensively drug-resistant typhoid is broadly spreading in Pakistan, and this is a very serious concern over antibiotic failure around the world. Pakistan was long considered a region with a low prevalence of human immunodeficiency virus, but now the disease is spreading at an alarming rate. Globally, Pakistan has the third highest burden of maternal, fetal and child mortality. In the last 10 years or so, around 10,000 cases of dengue have been reported with around 800 deaths, including children. Other issues related to children’s environmental health in Pakistan include cholera because of poor sanitation and hygiene, respiratory disease due to pollution, exposure to pesticides, diarrhea, occupational hazards as a result of child labor, etc.
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LEE, H., K. KOTLOFF, P. CHUKASERM, S. SAMOSORNSUK, P. CHOMPOOK, J. L. DEEN, L. VON SEIDLEIN, J. D. CLEMENS, and C. WANPEN. "Shigellosis remains an important problem in children less than 5 years of age in Thailand." Epidemiology and Infection 133, no. 3 (January 14, 2005): 469–74. http://dx.doi.org/10.1017/s0950268804003590.

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This is a review of existing data on the burden of shigellosis in Thailand to determine trends, vulnerable groups, predominant species and serotypes, and antimicrobial resistance patterns. Diarrhoea and dysentery morbidity and mortality data from 1991 to 1999 was collected from the routine surveillance system and demographic data from the government census. International and local literature published between 1988 and 2000 was systematically reviewed. Based on the routine surveillance system, the annual incidence of bacillary dysentery decreased from 1·3 to 0·2/10000 persons per year. The remaining burden is highest in children <5 years of age at 2·7/10000 persons per year. In comparison, a prospective study utilizing active surveillance found an incidence in children <5 years of age that was more than 100-fold higher at 640/10000 persons per year. Despite the decrease in morbidity and mortality based on routinely collected data, shigellosis remains an important problem in children <5 years of age in Thailand.
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Chulasak, R., W. Phothachareon, and C. Sawatdeenarunat. "Economic Analysis of Applying Biomass Stove to Produce Hot Water Serving Child Development Center: The Case Study Of Omkoi District, Chiangmai, Thailand." AJARCDE | Asian Journal of Applied Research for Community Development and Empowerment 3, no. 1 (December 24, 2019): 17–18. http://dx.doi.org/10.29165/ajarcde.v3i1.16.

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This research aims to perform the techno-economic feasibility of the applied hybrid biomass stove to produce hot water for serving Child Development Center (CDC) in Omkoi District, Chiang Mai, Thailand. The hot water generated from the stove could help to decrease LPG usage and enhance household economics. Many activities in CDC (i.e., children showering during the winter season, cloth washing, and utensils cleaning among others) require hot water to prevent the contamination of harmful germs which could cause many diseases such as diarrhea in young children. Presently, Asian Development College for Community Economy and Technology, Chiang Mai Rajabhat University (adiCET) has installed the hybrid stove to the in Omkoi district. The biomass stove could generate 90 °C hot water using plant/agriculture waste as the fuel. However, the economical parameters (i.e., Payback Period, Net Present Value and Internal Rate of Return) could strengthen the technology. The results from this study could be used as one of the guidelines for policymakers to design the appropriate programs for enhancing the CDC using the waste-to-energy concept.
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Jaisue, Siriluk, Sommaly Phomtavong, Sasithorn Eua-anant, and Glenn N. Borlace. "Dispensing pattern for acute non-infectious diarrhoea in children at community pharmacies in Thailand." Journal of Pharmacy Practice and Research 47, no. 5 (October 2017): 383–88. http://dx.doi.org/10.1002/jppr.1345.

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Dalsgaard, Anders, Anita Forslund, Oralak Serichantalergs, and Dorthe Sandvang. "Distribution and Content of Class 1 Integrons in Different Vibrio cholerae O-Serotype Strains Isolated in Thailand." Antimicrobial Agents and Chemotherapy 44, no. 5 (May 1, 2000): 1315–21. http://dx.doi.org/10.1128/aac.44.5.1315-1321.2000.

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ABSTRACT In this study, 176 clinical and environmental Vibrio cholerae strains of different O serotypes isolated in Thailand from 1982 to 1995 were selected and studied for the presence of class 1 integrons, a new group of genetic elements which carry antibiotic resistance genes. Using PCR and DNA sequencing, we found that 44 isolates contained class 1 integrons harboring the aadB,aadA2, blaP1, dfrA1, anddfrA15 gene cassettes, which encode resistance to gentamicin, kanamycin, and tobramycin; streptomycin and spectinomycin; β-lactams; and trimethoprim, respectively. Each cassette array contained only a single antibiotic resistance gene. Although resistance genes in class 1 integrons were found in strains from the same epidemic, as well as in unrelated non-O1, non-O139 strains isolated from children with diarrhea, they were found to encode only some of the antibiotic resistance expressed by the strains. Serotype O139 strains did not contain class 1 integrons. However, the appearance and disappearance of the O139 serotype in the coastal city Samutsakorn in 1992 and 1993 were associated with the emergence of a distinct V. cholerae O1 strain which contained the aadA2resistance gene cassette. A 150-kb self-transmissible plasmid found in three O1 strains isolated in 1982 contained the aadB gene cassette. Surprisingly, several strains harbored two integrons containing different cassettes. Thus, class 1 integrons containing various resistance gene cassettes are distributed among differentV. cholerae O serotypes of mainly clinical origin in Thailand.
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Ivanov, Dmitry O., Valentina V. Malinovskaya, Vladimir N. Timchenko, Tatyana A. Kaplina, and Jean-Claude Hakizimana. "Global and pediatric aspects of Zika virus infection." Pediatrician (St. Petersburg) 7, no. 1 (March 15, 2016): 129–34. http://dx.doi.org/10.17816/ped71129-134.

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This article presents the results of data analysis or references on etiology, epidemiology, pathogenesis, clinical features, therapy and prophylaxis of Zika virus infection. The article presents the results of the literature analysis of the data on the etiology, epidemiology, pathogenesis, clinical presentation, treatment and prevention of Zika virus infection. Currently Zika fever is common in tropical climates (Uganda, Brazil, Haiti, Colombia, Ecuador, El Salvador, Venezuela, Jamaica, Thailand, etc.). However, a large number of travelers and areolas mosquito habitat Αedes kind of make this a global problem. Acquired Zika virus infection usually occurs in mild and/or moderate forms. The development of severe forms occurs mainly in people with a weakened immune system or autoimmune diseases. Patients affected with Zika virus may develop neurological complications such as encephalitis, myelitis, optic neuritis, meningoencephalitis, Guillain-Barre syndrome. Transplacental and sexual transmissions contribute to an increase in the number of cases among children, including newborns. Zika congenital infection is characterized with brain damage, hearing and sight. Acquired Zika fever in children is accompanied by the presence of the following syndromes: subfebrile fever, mild intoxication, maculopapular rash with a landmark distribution, arthralgia, myalgia, photophobia and conjunctivitis, diarrhea rarely observed. In the laboratory diagnosis are used virological, molecular biological and serological methods. There are no specific prophylactic methods.To treat Zika virus infection, may be used recombinant human inteferona α2β and interferon inducers.
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Laoprasopwattana, Kamolwish, Wannee Limpitikul, and Alan Geater. "Using Clinical Profiles and Complete Blood Counts to Differentiate Causes of Acute Febrile Illness during the 2009–11 Outbreak of Typhoid and Chikungunya in a Dengue Endemic Area." Journal of Tropical Pediatrics 66, no. 5 (February 4, 2020): 504–10. http://dx.doi.org/10.1093/tropej/fmaa006.

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Abstract Background and aims After the 2009–11 outbreak of typhoid and chikungunya (CHIK) in Thailand, an effort was made to use complete blood counts and clinical profiles to differentiate these diseases to facilitate earlier specific treatment. Methods Patients aged 2–15 years having fever on first visit ≤3 days without localizing signs were enrolled retrospectively. Typhoid fever was confirmed by hemoculture, dengue by nonstructural protein-1 or polymerase chain reaction (PCR), and CHIK by PCR. Febrile children with negative results for these infections were classified as other acute febrile illness (AFI). Results Of the 264 cases, 56, 164, 25 and 19 had typhoid fever, dengue viral infection (DVI), CHIK and other AFI, respectively. Arthralgia had sensitivity, specificity, positive predictive value (PPV) and negative predictive value of 0.96, 0.97, 0.80 and 0.99, respectively, to differentiate CHIK from the others. After excluding CHIK by arthralgia, the PPV of the WHO 1997 and 2009 criteria for DVI increased from 0.65 and 0.73 to 0.95 and 0.84, respectively. Children with one of myalgia, headache or leukopenia had sensitivity of 0.84, specificity of 0.76 and PPV of 0.92 to differentiate DVI from typhoid and other AFIs. Patients with one of abdominal pain, diarrhea or body temperature &gt;39.5°C were more likely to have typhoid fever than another AFI with PPV of 0.90. Conclusion Using this flow chart can help direct physicians to perform more specific tests to confirm the diagnosis and provide more specific treatment. Nevertheless, clinical follow-up is the most important tool in unknown causes of febrile illness.
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Isenbarger, D. W., P. Echeverria, L. Bodhidatta, U. Umpawasiri, W. Nirdnoy, C. W. Hoge, and C. Pitarangsi. "Prospective study of the incidence of diarrheal disease and Helicobacter pylori infection among children in an orphanage in Thailand." American Journal of Tropical Medicine and Hygiene 59, no. 5 (November 1, 1998): 796–800. http://dx.doi.org/10.4269/ajtmh.1998.59.796.

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Shwe, Valerie Daw Tin, Ratana Somrongthong, and Robert Sedgwick Chapman. "HOUSEHOLD DRINKING WATER STORAGE INTERVENTION TO ASSESS ITS IMPACT ON WATER QUALITY AT MAE LA TEMPORARY SHELTER." Journal of Chitwan Medical College 9, no. 3 (September 26, 2019): 3–14. http://dx.doi.org/10.54530/jcmc.8.

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Background: Diarrhoea cases make up nearly two-thirds of total clinic visits at Mae La temporary shelter, Thailand, 40% being under five diarrhoeal cases. The use of a safe storage container for drinking water may prevent contamination and reduce diarrhoeal disease morbidity in camp residents. The aim of this study was to evaluate the use of safe drinking water storage containers and diarrhoeal diseases in under 5 children at the Mae La temporary shelter. Methods: A randomized controlled trail was conducted in 400 households with at least one child under 5 years old over a period of four months. Intervention households received safe containers, while control households did not. Households were visited twice weekly during the three-month follow-up. Recent occurrence of diarrhoea in children under five was ascertained and residual chlorine levels in drinking water were measured. The results were analyzed by chi-square tests and survival analyses. Results: Overall, the study found a 75% reduction of under five diarrhoea in the intervention group and 3.5-times less risk than control group subjects. Key factors associated with under five diarrhoea were: study group participation, no formal education of household primary caregivers; main sources of acquired drinking water; awareness regarding tap water chlorination; length of time living in camp Conclusion: In conclusion, intervention group participants were found to experience a reduction in diarrhoea morbidity when compared to their control group counterparts. E. coli contamination of drinking water was very common, suggesting little or no protection from chlorination.
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Shwe, Valerie Daw Tin, Ratana Somrongthong, and Robert Sedgwick Chapman. "Household Drinking Water Storage Intervention to Assess its Impact on Water Quality at Mae La Temporary Shelter." Journal of Chitwan Medical College 9, no. 3 (September 25, 2019): 3–14. http://dx.doi.org/10.3126/jcmc.v9i3.25776.

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Background: Diarrhoea cases make up nearly two-thirds of total clinic visits at Mae La temporary shelter, Thailand, 40% being under five diar­rhoeal cases. The use of a safe storage container for drinking water may prevent contamination and reduce diarrhoeal disease morbidity in camp residents. The aim of this study was to evaluate the use of safe drinking water storage containers and diarrhoeal diseases in under 5 children at the Mae La temporary shelter. Methods: A randomized controlled trail was conducted in 400 households with at least one child under 5 years old over a period of four months. In­tervention households received safe containers, while control households did not. Households were visited twice weekly during the three-month follow-up. Recent occurrence of diarrhoea in children under five was as­certained and residual chlorine levels in drinking water were measured. The results were analyzed by chi-square tests and survival analyses. Results: Overall, the study found a 75% reduction of under five diarrhoea in the intervention group and 3.5-times less risk than control group sub­jects. Key factors associated with under five diarrhoea were: study group participation, no formal education of household primary caregivers; main sources of acquired drinking water; awareness regarding tap water chlori­nation; length of time living in camp Conclusions: In conclusion, intervention group participants were found to experience a reduction in diarrhoea morbidity when compared to their control group counterparts. E. coli contamination of drinking water was very common, suggesting little or no protection from chlorination.
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Stracke, Katharina, Poom Adisakwattana, Suparat Phuanukoonnon, Tippayarat Yoonuan, Akkarin Poodeepiyasawat, Paron Dekumyoy, Kittipong Chaisiri, et al. "Field evaluation of the gut microbiome composition of pre-school and school-aged children in Tha Song Yang, Thailand, following oral MDA for STH infections." PLOS Neglected Tropical Diseases 15, no. 7 (July 26, 2021): e0009597. http://dx.doi.org/10.1371/journal.pntd.0009597.

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Soil-transmitted helminths, such as roundworms (Ascaris lumbricoides), whipworms (Trichuris trichiura) and hookworms (Necator americanus and Ancylostoma spp.), are gastrointestinal parasites that occur predominantly in low- to middle-income countries worldwide and disproportionally impact children. Depending on the STH species, health status of the host and infection intensity, direct impacts of these parasites include malnutrition, anaemia, diarrhoea and physical and cognitive stunting. The indirect consequences of these infections are less well understood. Specifically, gastrointestinal infections may exert acute or chronic impacts on the natural gut microfauna, leading to increased risk of post-infectious gastrointestinal disorders, and reduced gut and overall health through immunomodulating mechanisms. To date a small number of preliminary studies have assessed the impact of helminths on the gut microbiome, but these studies are conflicting. Here, we assessed STH burden in 273 pre-school and school-aged children in Tha Song Yang district, Tak province, Thailand receiving annual oral mebendazole treatment. Ascaris lumbricoides (107/273) and Trichuris trichiura (100/273) were the most prevalent species and often occurred as co-infections (66/273). Ancylostoma ceylanicum was detected in a small number of children as well (n = 3). All of these infections were of low intensity (<4,999 or 999 eggs per gram for Ascaris and Trichuris respectively). Using this information, we characterised the baseline gut microbiome profile and investigated acute STH-induced alterations, comparing infected with uninfected children at the time of sampling. We found no difference between these groups in bacterial alpha-diversity, but did observe differences in beta-diversity and specific differentially abundant OTUs, including increased Akkermansia muciniphila and Bacteroides coprophilus, and reduced Bifidobacterium adolescentis, each of which have been previously implicated in STH-associated changes in the gut microfauna.
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33

Rahman, Mustafizur, Jelle Matthijnssens, Xuelei Yang, Thomas Delbeke, Ingrid Arijs, Koki Taniguchi, Miren Iturriza-Gómara, Nadia Iftekharuddin, Tasnim Azim, and Marc Van Ranst. "Evolutionary History and Global Spread of the Emerging G12 Human Rotaviruses." Journal of Virology 81, no. 5 (March 1, 2007): 2382–90. http://dx.doi.org/10.1128/jvi.01622-06.

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ABSTRACT G12 rotaviruses were first detected in diarrheic children in the Philippines in 1987, but no further cases were reported until 1998. However, G12 rotaviruses have been detected all over the world in recent years. Here, we report the worldwide variations of G12 rotaviruses to investigate the evolutionary mechanisms by which they managed to spread globally in a short period of time. We sequenced the complete genomes (11 segments) of nine G12 rotaviruses isolated in Bangladesh, Belgium, Thailand, and the Philippines and compared them with the genomes of other rotavirus strains. Our genetic analyses revealed that after introduction of the VP7 gene of the rare G12 genotype into more common local strains through reassortment, a vast genetic diversity was generated and several new variants with distinct gene constellations emerged. These reassortment events most likely took place in Southeast Asian countries and spread to other parts of the world. The acquirement of gene segments from human-adapted rotaviruses might allow G12 to better propagate in humans and hence to develop into an important emerging human pathogen.
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34

Varavithya, W., K. Vathanophas, L. Bodhidatta, P. Punyaratabandhu, R. Sangchai, S. Athipanyakom, C. Wasi, and P. Echeverria. "Importance of salmonellae and Campylobacter jejuni in the etiology of diarrheal disease among children less than 5 years of age in a community in Bangkok, Thailand." Journal of Clinical Microbiology 28, no. 11 (1990): 2507–10. http://dx.doi.org/10.1128/jcm.28.11.2507-2510.1990.

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35

DALSGAARD, A., A. FORSLUND, L. BODHIDATTA, O. SERICHANTALERGS, C. PITARANGSI, L. PANG, T. SHIMADA, and P. ECHEVERRIA. "A high proportion of Vibrio cholerae strains isolated from children with diarrhoea in Bangkok, Thailand are multiple antibiotic resistant and belong to heterogenous non-O1, non-O139 O-serotypes." Epidemiology and Infection 122, no. 2 (April 1999): 217–26. http://dx.doi.org/10.1017/s0950268899002137.

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Results of a surveillance on cholera conducted with patients seen at the Children Hospital in Bangkok, Thailand from August 1993 to July 1995 are presented. Annually, isolation rates for Vibrio cholerae varied between 1·7 and 4·4% of patients with diarrhoea. V. cholerae O1 serotype Ogawa accounted for between 31 and 47% of patients cultured positive for V. cholerae, whereas the O139 serotype dominated in early 1994 after which it disappeared. Non-O1, non-O139 strains were isolated at similar rates as serotype O1 in 1993 and 1994, but accounted for 69% of V. cholerae culture positive specimens in 1995. However, the annual proportion of the isolation of non-O1, non-O139 strains showed little variation and remained low between 1·0 and 1·3%. Serotyping of 69 epidemiological unrelated non-O1, non-O139 strains produced 37 different O-serotypes. BglI ribotyping of serotypes containing more than two strains demonstrated a high degree of heterogeneity within and between serotypes, except seven serotype O37 strains which showed an identical ribotype suggesting clonality. None of the 69 strains hybridized with a cholera toxin probe and only two strains hybridized with a heat-stable enterotoxin probe. Susceptibility testing to 12 antibiotics showed that 40 of 69 (58%) non-O1, non-O139 strains were resistant to colistin, streptomycin and sulphisoxazole and 28 of 69 (41%) were multiple antibiotic resistant (MAR; [ges ]4 antibiotics). Although 26 of 69 (38%) strains contained one or more plasmids, the plasmids were of low molecular weights and did not seem to encode antibiotic resistance. The results of the present study showed that a high proportion of heterogenous MAR V. cholerae non-O1, non-O139 strains were isolated from children at the hospital. With reference to the emergence of V. cholerae O139 in 1992, we suggest that non-O1, non-O139 strains should be monitored carefully to detect new serotypes with a possible epidemic potential, but also to determine the development and mechanism of antibiotic resistance.
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36

Shinoda, Sumio. "Special Issue on J-GRID (Japan Initiative for Global Research Network on Infectious Disease)." Journal of Disaster Research 9, no. 5 (October 1, 2014): 765–67. http://dx.doi.org/10.20965/jdr.2014.p0765.

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In the developed countries including Japan, malignant tumor (cancer), heart disease and cerebral apoplexy are major causes of death, but infectious diseases still responsible for high mortality in the developing countries, especially for children less than 5 years of age. World Health Statistics published byWHO indicates a high percentage of mortality from infectious diseases such as HIV/AIDS, diarrhea, measles, malaria and pneumonia in children of South and Southeast Asian and African countries (World Health Statistics 2014,World Health Organization). Many of these infectious diseases have the potential for borderless transmission and invasion to Japan. Given this situation, Japan’s Ministry of Education, Culture, Sports, Science and Technology (MEXT) introduced Phase I of a program “Founding Research Centers for Emerging and Reemerging Infectious Diseases,” running from fiscal 2005 to 2009 and involving 8 Japanese universities and 2 Japanese research centers. The program was established to: 1) Create of a domestic research structure to promote the accumulation of fundamental knowledge about infectious diseases, 2) Set up 13 overseas research collaboration centers in 8 countries at high risk of emerging and reemerging infections, Japanese researchers are stationed at these centers, where they conduct research in partnership with overseas instructors, 3) Develop a network among domestic and overseas research centers, 4) Develop human resources. The program, supervised by MEXT, and managed by the RIKEN Center of the Research Network for Infectious Diseases (Riken CRNID). Dr. Yoshiyuki Nagai, Program Director (PD), heads CRNID and is organizing the program. Phase II of the program was set up as the Japan Initiative for the Global Research Network on Infectious Diseases (J-GRID) and was established for fiscal 2010-2014. Participating universities, institutes and countries in J-GRID are as follows: Hokkaido University : Zambia Tohoku University : Philippines The University of Tokyo : China Tokyo Medical and Dental University : Ghana Osaka University : Thailand Kobe University : Indonesia Okayama University : India Nagasaki University : Vietnam Kenya (Associate*) Niigata University : Myanmar (Associate*) National Center for Global Health and Medicine : Vietnam National Institute of Animal Health : Thailand *Two associate members were involved in 2011. Each university and institute set up its collaborative research center in a country and conducts research on infectious diseases, especially typical regional diseases. The program’s outcome of each collaborative center is announced by the publication of various research papers or outreach programs, such as open lectures for citizens, and so on. The Asian-African Research Forum (AARF) on Infectious Disease organized by J-GRID is dedicated to reporting and discussing the research results of the collaborative research centers. Details and activities of J-GRID can be seen at http://www.crnid.riken.jp/jgrid/. The Figs. 1 and 2 show examples of the home page indicating the countries and the collaborative research institutes involved. J-GRID publishes the magazine entitled “Monthly CRNID,” which is available by mail upon request to “https://krs.bz/crnid/m?f=2&m=1110&t=8cdk&v=076691d2.” This publication contains various topical information on infectious diseases, such as research papers, newly announced news from WHO, overseas trip news, domestic infections, new drug developments, explanations, events, etc. Phase II will terminate on March 2015 (the end of FY 2014), and Phase III will begin in April 2015 at the start of the new FY. This special issue on J-GRID is being edited on the occasion of the final year of Phase II. The outlines of J-GRID and those of all the collaborative research centers are reviewed by Dr. Nagai, PD of CRNID, and the representatives of each respective collaborative center in this issue. Finally, I extend my sincere thanks to all authors and reviewers involved in this special issue.
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37

Chongsuvivatwong, Virasakdi, Suwat Chariyalertsak, Edward McNeil, Somboon Aiyarak, Songwut Hutamai, Herbert L. DuPont, Zhi‐Dong Jiang, et al. "Epidemiology of Travelers’ Diarrhea in Thailand." Journal of Travel Medicine 16, no. 3 (May 1, 2009): 179–85. http://dx.doi.org/10.1111/j.1708-8305.2009.00331.x.

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38

Echeverria, P., L. R. Jackson, C. W. Hoge, M. K. Arness, G. R. Dunnavant, and R. R. Larsen. "Diarrhea in U.S. troops deployed to Thailand." Journal of Clinical Microbiology 31, no. 12 (1993): 3351–52. http://dx.doi.org/10.1128/jcm.31.12.3351-3352.1993.

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39

MITSUI, YOSHINORI, CHARNCHUDHI CHANYASANHA, CHAWEEWON BOONSHUYAR, MASAAKI SHIMADA, and KAZUHIKO MOJI. "INCIDENCE OF TRAVELERS' DIARRHEA AMONG JAPANESE VISITING THAILAND." Tropical Medicine and Health 32, no. 1 (2004): 21–26. http://dx.doi.org/10.2149/tmh.32.21.

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40

Zella, G. C., and E. J. Israel. "Chronic Diarrhea in Children." Pediatrics in Review 33, no. 5 (May 1, 2012): 207–18. http://dx.doi.org/10.1542/pir.33-5-207.

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41

Radlovic, Nedeljko, Zoran Lekovic, Biljana Vuletic, Vladimir Radlovic, and Dusica Simic. "Acute diarrhea in children." Srpski arhiv za celokupno lekarstvo 143, no. 11-12 (2015): 755–62. http://dx.doi.org/10.2298/sarh1512755r.

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Acute diarrhea (AD) is the most frequent gastroenterological disorder, and the main cause of dehydration in childhood. It is manifested by a sudden occurrence of three or more watery or loose stools per day lasting for seven to 10 days, 14 days at most. It mainly occurs in children until five years of age and particularly in neonates in the second half-year and children until the age of three years. Its primary causes are gastrointestinal infections, viral and bacterial, and more rarely alimentary intoxications and other factors. As dehydration and negative nutritive balance are the main complications of AD, it is clear that the compensation of lost body fluids and adequate diet form the basis of the child?s treatment. Other therapeutic measures, except antipyretics in high febrility, antiparasitic drugs for intestinal lambliasis, anti-amebiasis and probiotics are rarely necessary. This primarily regards uncritical use of antibiotics and intestinal antiseptics in the therapy of bacterial diarrhea. The use of antiemetics, antidiarrhetics and spasmolytics is unnecessary and potentially risky, so that it is not recommended for children with AD.
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42

DeWitt, T. G. "Acute Diarrhea in Children." Pediatrics in Review 11, no. 1 (July 1, 1989): 6–12. http://dx.doi.org/10.1542/pir.11-1-6.

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43

Bobrova, V. I. "Diarrhea syndrome in children." SOVREMENNAYA PEDIATRIYA 75, no. 3 (April 30, 2016): 115–20. http://dx.doi.org/10.15574/sp.2016.75.115.

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44

Zulqarnain, Arif, Zeeshan Jaffar, and Imran Iqbal. "MALNOURISHED CHILDREN WITH DIARRHEA." Professional Medical Journal 22, no. 05 (May 10, 2015): 610–14. http://dx.doi.org/10.29309/tpmj/2015.22.05.1275.

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Objectives: “To assess the frequency of serum electrolytes (Na+, K+ & Ca+)disturbances in malnourished children with diarrhea”. Study Design: Cross-sectional.Setting: Pediatrics Department Nishtar Hospital Multan. Period: 01-07-2013 to 31-12-2013.Methodology: Approval from the institutional ethical committee was taken. Malnourishedchildren with diarrhea admitted to Pediatrics Department Nishtar Hospital Multan wereregistered. Children meeting the inclusion and exclusion criteria enrolled in the study. Results:In this study there were 90 patients which were found to be malnourished and having diarrhea.The average age of patients was 3.28±1.2 years and the average duration of diarrhea was4.67±0.821 days. There were 58(64.4%) males and 32(35.5%) female patients. Hyponatremiawas present in 28(31.1%) patients, Hypokalemia was present in 55(61.1%) while Hypocalcemiawas present in 12(13.3%).Conclusion: Serum electrolyte disturbances in malnourished childrenare obvious during diarrheal illness particularly in those patients with Grade III malnutrition andmeasurement of these Serum electrolytes is helpful for immediate therapy to avoid serious lifethreatening situations.
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Zella, Garrett C., and Esther J. Israel. "Chronic Diarrhea in Children." Pediatrics In Review 33, no. 5 (May 1, 2012): 207–18. http://dx.doi.org/10.1542/pir.33.5.207.

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46

Leung, Alexander K. C., and W. Lane M. Robson. "Acute diarrhea in children." Postgraduate Medicine 86, no. 8 (December 1989): 161–74. http://dx.doi.org/10.1080/00325481.1989.11704505.

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47

Ashkenazi, Shai, Eli Schwartz, and Miguel O’Ryan. "Travelers’ Diarrhea in Children." Pediatric Infectious Disease Journal 35, no. 6 (June 2016): 698–700. http://dx.doi.org/10.1097/inf.0000000000001145.

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48

Plourde, Pierre J. "Travellers' diarrhea in children." Paediatrics & Child Health 8, no. 2 (February 2003): 99–103. http://dx.doi.org/10.1093/pch/8.2.99.

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49

Udall, John N. "SECRETORY DIARRHEA IN CHILDREN." Pediatric Clinics of North America 43, no. 2 (April 1996): 333–53. http://dx.doi.org/10.1016/s0031-3955(05)70409-0.

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50

Ramaswamy, Kannan, and Kevan Jacobson. "INFECTIOUS DIARRHEA IN CHILDREN." Gastroenterology Clinics of North America 30, no. 3 (September 2001): 611–24. http://dx.doi.org/10.1016/s0889-8553(05)70201-6.

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