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Journal articles on the topic 'Diastolic dysfunction and pulmonary artery pressure'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Moser, Debra K., Susan K. Frazier, Mary A. Woo, and Linda K. Daley. "Normal Fluctuations in Pulmonary Artery Pressures and Cardiac Output in Patients with Severe Left Ventricular Dysfunction." European Journal of Cardiovascular Nursing 1, no. 2 (2002): 131–37. http://dx.doi.org/10.1016/s1474-51510200013-0.

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Background: One barrier to accurate interpretation of changes in hemodynamic pressures and cardiac output is lack of data about what constitutes a normal fluctuation. Few investigators have examined normal fluctuations in these parameters and none have done so in patients with left ventricular dysfunction. Aims: To describe normal fluctuations in pulmonary artery pressures and cardiac output in patients with left ventricular dysfunction. Methods: Hemodynamically stable advanced heart failure patients ( N=39; 55±6 years old; 62% male) with left ventricular dysfunction (mean ejection fraction 22

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2

Akram, Ramadan Farag Elburki, Patil Ravikant, and Awad Amgrab Emadaldin. "Assessment of Diastolic Dysfunction in Normotensive Asymptomatic Type II Diabetes Mellitus and Correlation with Pulmonary Artery Pressure." International Journal of Research and Review 7, no. 5 (2020): 8–13. https://doi.org/10.5281/zenodo.3938055.

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<strong>Aim: </strong>To estimate the prevalence of Diastolic Dysfunction in normotensive asymptomatic type 2 diabetes mellitus and determining its correlation with increased pulmonary artery pressure (PAP). <strong>Methods:</strong> Retrospective and cross-sectional study with data obtained from Sevasadan Lifeline Super Speciality hospitals between 10/1/2020 to 31/3/2020. A total of 111 patients records were retrieved. This study included inpatients of type 2 DM of all age groups and patients with cardiac diseases were excluded from the study. For each patient, clinical profile like

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Elrakhawy, Hany M., Mohamed A. Alassal, Ayman M. Shaalan, Ahmed A. Awad, Sameh Sayed, and Mohammad M. Saffan. "Impact of Major Pulmonary Resections on Right Ventricular Function: Early Postoperative Changes." Heart Surgery Forum 21, no. 1 (2018): 009. http://dx.doi.org/10.1532/hsf.1864.

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Background: Right ventricular (RV) dysfunction after pulmonary resection in the early postoperative period is documented by reduced RV ejection fraction and increased RV end-diastolic volume index. Supraventricular arrhythmia, particularly atrial fibrillation, is common after pulmonary resection. RV assessment can be done by non-invasive methods and/or invasive approaches such as right cardiac catheterization. Incorporation of a rapid response thermistor to pulmonary artery catheter permits continuous measurements of cardiac output, right ventricular ejection fraction, and right ventricular en

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Sachdev, Vandana, Roberto F. Machado, Yukitaka Shizukudu, et al. "Diastolic Dysfunction Is an Independent Risk Factor for Death in Patients with Sickle Cell Disease." Blood 106, no. 11 (2005): 206. http://dx.doi.org/10.1182/blood.v106.11.206.206.

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Abstract Background. Pulmonary hypertension, defined by an elevated pulmonary artery systolic pressure measured by Doppler-echocardiogram, has been identified as the major predictor of death in the adult sickle cell disease population. While diastolic dysfunction is also observed in this population, the prevalence in unselected patients, the association with high pulmonary artery systolic pressure, and the attributable mortality remain unknown. Methods. Diastolic function parameters, pulmonary artery systolic pressures and right and left ventricular size and function were measured prospectivel

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Titova, O. N., N. A. Kuzubova, A. L. Aleksandrov, V. E. Perley, and A. Yu Gichkin. "Pulmonary and cardiac hemodynamics in COPD and cystic fibrosis by Doppler echocardiography." Russian Medical Inquiry 5, no. 7 (2021): 456–61. http://dx.doi.org/10.32364/2587-6821-2021-5-7-456-461.

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Aim: to assess the functionality of the right heart in patients with chronic obstructive pulmonary disease (COPD), mixed cystic fibrosis (CF), and cystic fibrosis lung disease by Doppler echocardiography. Patients and Methods: 30 adults with CF and 82 adults with COPD underwent ultrasonography to evaluate pulmonary and cardiac hemodynamics. All patients were divided into four groups based on the presence/absence of clinical signs of right ventricular failure and pulmonary hypertension. Results: in COPD, diastolic dysfunction of the right heart can be subclinical preceding systolic impairment.

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Akkaya, Suleyman, and Umit Cakmak. "Changes in Cardiac Structure and Function of Recipients after Kidney Transplantation." Journal of Clinical Medicine 13, no. 12 (2024): 3629. http://dx.doi.org/10.3390/jcm13123629.

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Background: Chronic kidney disease (CKD) elevates the risk of cardiovascular disease (CVD) and mortality. Uremic cardiomyopathy, frequently observed in CKD and end-stage renal disease (ESRD), involves alterations in cardiac structure and function, which may reverse post-kidney transplantation, although data remain controversial. This study examines the relationship between graft function and changes in cardiac parameters pre- and post-transplantation in kidney transplant recipients. Methods: A total of 145 pediatric and adult recipients of living or deceased donor kidney transplants were enrol

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Rakhimova, D., A. Alyavi, and D. Muminov. "THE PATHOPHYSIOLOGICAL MECHANISMS DYSFUNCTION OF THE CARDIORESPIRATORY SYSTEM IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ASTHMA." Slovak international scientific journal, no. 65 (July 7, 2022): 7–9. https://doi.org/10.5281/zenodo.6805554.

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To study the pathophysiological mechanisms dysfunctions of the cardiorespiratory system in patients with chronic obstructive pulmonary disease and asthma. During the decrease in forced expiratory volume in the first second - FEV1 less than 50% of the due and the mean increase in middle pulmonary artery pressure greater than 25 mm Hg, at all patients were revealed signs of diastolic dysfunction of the right ventricle of heart, more pronounced in patients with COPD.

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Zorzi, Maria F., Emmanuelle Cancelli, Marco Rusca, Matthias Kirsch, Patrick Yerly, and Lucas Liaudet. "The prognostic value of pulmonary artery compliance in cardiogenic shock." Pulmonary Circulation 9, no. 3 (2019): 204589401987716. http://dx.doi.org/10.1177/2045894019877161.

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The aim of this study was to evaluate the pathophysiological role and the prognostic significance of pulmonary artery compliance (CPA), a measure of right ventricular pulsatile afterload, in cardiogenic shock. We retrospectively included 91 consecutive patients with cardiogenic shock due to primary left ventricular failure, monitored with a pulmonary artery catheter within the first 24 h. CPA was calculated as the ratio of stroke volume to pulmonary artery pulse pressure, and we determined whether CPA predicted mortality and whether it performed better than other pulmonary hemodynamic variable

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Larsen, Karl-Otto, Ivar Sjaastad, Aud Svindland, Kurt A. Krobert, Ole Henning Skjønsberg, and Geir Christensen. "Alveolar hypoxia induces left ventricular diastolic dysfunction and reduces phosphorylation of phospholamban in mice." American Journal of Physiology-Heart and Circulatory Physiology 291, no. 2 (2006): H507—H516. http://dx.doi.org/10.1152/ajpheart.00862.2005.

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Chronic obstructive pulmonary disease (COPD) may lead to pulmonary hypertension (PH) and reduced function of the right ventricle (RV). However, COPD patients may also develop left ventricular (LV) diastolic dysfunction. We hypothesized that alveolar hypoxia induces LV diastolic dysfunction and changes in proteins governing Ca2+ removal from cytosol during diastole. Mice exposed to 10% oxygen for 1, 2, or 4 wk were compared with controls. Cardiac hemodynamics were assessed with Doppler echocardiography and a microtransducer catheter under general anesthesia. The pulmonary artery blood flow acce

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10

Masha, Luke, James Stone, Danielle Stone, Jun Zhang, and Luo Sheng. "Pulmonary Catherization Data Correlate Poorly with Renal Function in Heart Failure." Cardiorenal Medicine 8, no. 3 (2018): 183–91. http://dx.doi.org/10.1159/000487203.

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Background: The mechanisms of renal dysfunction in heart failure are poorly understood. We chose to explore the relationship of cardiac filling pressures and cardiac index (CI) in relation to renal dysfunction in advanced heart failure. Objectives: To determine the relationship between renal function and cardiac filling pressures using the United Network of Organ Sharing (UNOS) pulmonary artery catherization registry. Methods: Patients over the age of 18 years who were listed for single-organ heart transplantation were included. Exclusion criteria included a history of mechanical circulatory s

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Shrivastava, Smit, Animesh Chaudhary, and Prabhat Pandey. "Cardiac Manifestations in Adult Sickle Cell Disease Patients at a Tertiary Care Hospital in Chhattisgarh, India." Journal of Evolution of Medical and Dental Sciences 10, no. 21 (2021): 1567–74. http://dx.doi.org/10.14260/jemds/2021/328.

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BACKGROUND Sickle cell disease is the commonest haemoglobinopathy. Recent advanced therapeutic approaches are enabling the sickle cell patients to survive beyond adulthood. METHODS The study provides important data on cardiovascular abnormalities in sickle cell disorder in Chhattisgarh by employing a non-invasive method of two-dimensional colour Doppler echocardiography. RESULTS The present study suggests that sickle cell disease has association with left ventricular diastolic dysfunction and pulmonary artery hypertension and no association with other echocardiographic findings including left

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12

Neuman, Yoram, Andy Kotliroff, Tamir Bental, Robert J. Siegel, Daniel David, and Michael Lishner. "Pulmonary artery pressure and diastolic dysfunction in normal left ventricular systolic function." International Journal of Cardiology 127, no. 2 (2008): 174–78. http://dx.doi.org/10.1016/j.ijcard.2007.06.003.

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13

Ullah, Kaleem, Zafar Niaz, Sami Ullah Mumtaz, and Sajid Abaidullah. "Presence of Left Ventricular Diastolic Dysfunction in Patients of Chronic Obstructive Pulmonary Disease." Annals of King Edward Medical University 24, no. 1 (2018): 593–97. http://dx.doi.org/10.21649/akemu.v24i1.2306.

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The relationship between chronic obstructive pulmonary disease (COPD) and cardiovascular diseases strongly exists as diastolic dysfunction is commonly reported in COPD patients. Objective: This study was conducted to determine the presence of left ventricular diastolic dysfunction in patients of COPD. Material and Methods: A cross sectional study was conducted in Mayo Hospital Lahore for one year. A total of 50 confirmed cases of COPD were included in the study. History of smoking was taken and subjects were examined for positive signs for the clinical, ECG, x-ray chest PA view and pulmonary f

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KULIK, EKATERINA G., VALENTINA I. PAVLENKO, ANASTASIA A. BAKINA, and SVETLANA V. NARYSHKINA. "IMPACT OF THE PREVIOUS 2019 NOVEL CORONAVIRUS INFECTION ON THE STRUCTURAL AND FUNCTIONAL PARAMETERS OF THE RIGHT HEART AND ON PULMONARY HEMODYNAMICS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE." Bulletin of Contemporary Clinical Medicine 17, no. 1 (2024): 15–21. http://dx.doi.org/10.20969/vskm.2024.17(1).15-21.

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Abstract. Introduction. This paper presents the interim results of a prospective clinical study, in which we studied the long-term inﬂuence of 2019 novel coronavirus infection (2019-nCoV) on pulmonary-cardiac relationships in patients with chronic obstructive pulmonary disease. Aim: Studying the eﬀect provided by the previous 2019-nCoV on the structural and functional parameters of the right ventricle of the heart and on pulmonary hemodynamics in patients with chronic obstructive pulmonary disease. Materials and Methods. Over the years 2021-2023, we examined 43 patients with stable chronic obs

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Atienza-Ortiz, Gerlie, Olivia B. Hipolito, and Mylene U. Cornel. "Prevalence of Subclinical Right Ventricular Dysfunction Using Tissue Doppler Imaging Among Newly Diagnosed Obstructive Sleep Apnea (OSA) Patients in St. Luke’s Medical Center." Philippine Journal of Cardiology 41, no. 2 (2013): 66–70. http://dx.doi.org/10.69944/pjc.c41dac5181.

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BACKGROUND: Obstructive sleep apnea (OSA) is a syndrome characterized by repetitive obstruction of the upper airway during sleep, and is associated with frequent episodes of transient nocturnal pulmonary hypertension and consequently, possible right heart dysfunction. The aim of this study is to determine the prevalence of subclinical right ventricular (RV) dysfunction in newly diagnosed OSA patients. METHODS: This is a retrospective analytical study from March 2012 to February 2013. We reviewed the recent transthoracic echocardiography results of 37 patients diagnosed with OSA determined by t

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D’Alto, Michele, Emanuele Romeo, Paola Argiento, et al. "Hemodynamic changes after acute fluid loading in patients with systemic sclerosis without pulmonary hypertension." Pulmonary Circulation 9, no. 1 (2018): 204589401881608. http://dx.doi.org/10.1177/2045894018816089.

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A fluid challenge with a rapid infusion of saline helps to discriminate between pre- and post-capillary pulmonary hypertension (PH) and allows unmasking hidden post-capillary PH. Systemic sclerosis (SSc) patients may present with biventricular systolic and diastolic dysfunction. The aim of this study was to evaluate the hemodynamic changes of the pulmonary circulation in SSc patients without PH after a fluid challenge. Twenty-five SSc patients and 25 controls underwent right heart catheterization in basal conditions and after volume loading with saline infusion of 7 mL/kg over 5–10 min. At bas

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17

Davis, K. L., U. Mehlhorn, G. A. Laine, and S. J. Allen. "Myocardial edema, left ventricular function, and pulmonary hypertension." Journal of Applied Physiology 78, no. 1 (1995): 132–37. http://dx.doi.org/10.1152/jappl.1995.78.1.132.

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Left ventricular dysfunction has been reported in both experimentally induced and clinical pulmonary hypertension. However, the mechanism by which pulmonary hypertension causes left ventricular dysfunction is unknown. We hypothesized that acute pulmonary hypertension causes left ventricular myocardial interstitial edema and that it is this edema that causes left ventricular dysfunction. In pulmonary artery-banded or sham-operated dogs, left ventricular diameter (septal-free wall axis) and pressure were measured using sonomicrometry crystals and a micromanometer, respectively. These measurement

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Mendes-Ferreira, P., D. Santos-Ribeiro, R. Adão, et al. "Distinct right ventricle remodeling in response to pressure overload in the rat." American Journal of Physiology-Heart and Circulatory Physiology 311, no. 1 (2016): H85—H95. http://dx.doi.org/10.1152/ajpheart.00089.2016.

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Pulmonary arterial hypertension (PAH), the most serious chronic disorder of the pulmonary circulation, is characterized by pulmonary vasoconstriction and remodeling, resulting in increased afterload on the right ventricle (RV). In fact, RV function is the main determinant of prognosis in PAH. The most frequently used experimental models of PAH include monocrotaline- and chronic hypoxia-induced PAH, which primarily affect the pulmonary circulation. Alternatively, pulmonary artery banding (PAB) can be performed to achieve RV overload without affecting the pulmonary vasculature, allowing research

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Guliyeva, Aynur, Erkan Cakir, Hakan Yazan, et al. "Assessment of Right Heart Functions in Children with Mild Cystic Fibrosis." Klinische Pädiatrie 233, no. 05 (2021): 231–36. http://dx.doi.org/10.1055/a-1341-1698.

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ABSTRACT Background Cystic fibrosis (CF) is a multisystemic disease that prevalently involves the lungs. Hypoxemia occurs due to the existing of progressive damage to the pulmonary parenchyma and pulmonary vessels. The condition may cause systolic and diastolic dysfunction to the right ventricle due to the effects of high pulmonary artery systolic pressure (PASP). The study aimed to determine echocardiographic alterations in PASP, right ventricle (RV) anatomy, and functions in mild CF children. Materials and Methods RV anatomy, systolic, and diastolic functions were evaluated with conventional

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Leonova, E. I., E. I. Shmelev, and R. B. Amansakhedov. "Intracardiac hemodynamic abnormalities in patients with sarcoidosis." Russian Pulmonology 28, no. 5 (2018): 567–75. http://dx.doi.org/10.18093/0869-0189-2018-28-5-567-575.

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The aim of this study was to evaluate intracardiac hemodynamic abnormalities in patients with pulmonary sarcoidosis and to investigate relevant factors. Methods. The study involved 42 patients with chronic pulmonary sarcoidosis. Chest computed tomography (CT), echocardiography, body plethysmography, spirometry, 6-minute walking test, and measurements of lung diffusing capacity (DLCO), blood gases and blood C-reactive protein (CRP) were performed in all patients. Results. Chronic cor pulmonale was detected in 26.2% of patients. The right heart diastolic dysfunction was found in 14.3% of patient

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Allemann, Yves, Martin Rotter, Damian Hutter, et al. "Impact of acute hypoxic pulmonary hypertension on LV diastolic function in healthy mountaineers at high altitude." American Journal of Physiology-Heart and Circulatory Physiology 286, no. 3 (2004): H856—H862. http://dx.doi.org/10.1152/ajpheart.00518.2003.

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In pulmonary hypertension right ventricular pressure overload leads to abnormal left ventricular (LV) diastolic function. Acute high-altitude exposure is associated with hypoxia-induced elevation of pulmonary artery pressure particularly in the setting of high-altitude pulmonary edema. Tissue Doppler imaging (TDI) allows assessment of LV diastolic function by direct measurements of myocardial velocities independently of cardiac preload. We hypothesized that in healthy mountaineers, hypoxia-induced pulmonary artery hypertension at high altitude is quantitatively related to LV diastolic function

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Baldivia, Guilherme Cristianini, João Vitor Moraes Pithon Napoli, Josiane Motta e. Motta, Normando Gomes Vieira Filho, and Heno Ferreira Lopes. "Is hepatojugular reflux a good predictor of heart failure with preserved ejection fraction?" Revista da Associação Médica Brasileira 65, no. 5 (2019): 592–95. http://dx.doi.org/10.1590/1806-9282.65.5.592.

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SUMMARY Hypertension may occur with left ventricular (LV) diastolic dysfunction, and the consequence may be symptoms and signs of heart failure (HF). Hepatojugular reflux (HJR), described as a sign of regurgitation of the tricuspid valve, may reflect structural and functional changes of the LV in the hypertensive patient. The signal may be present in the presence of HF. Case: male, 49 years old with uncontrolled blood pressure. Physical examination showed jugular turgescence, HJR, and elevated blood pressure. Complementary exams showed signs of atrial and left ventricular overload in the elect

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Marangoni, S., S. Scalvini, M. Schena, M. Vitacca, A. Quadri, and G. Levi. "Right ventricular diastolic function in chronic obstructive lung disease." European Respiratory Journal 5, no. 4 (1992): 438–43. http://dx.doi.org/10.1183/09031936.93.05040438.

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Early detection of diastolic dysfunction in chronic obstructive lung disease (COLD) patients could have great prognostic value. Echocardiography has been shown to be a useful technique in studying left ventricular diastolic function. A noninvasive method of studying right ventricular diastolic function has not yet been reported. Pulsed Doppler echocardiography was used to assess right ventricular diastolic function in three groups of subjects: Group I: 35 COLD patients with pulmonary hypertension; Group II: 32 COLD patients without pulmonary hypertension; and Group III: 18 control subjects. Ra

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Dr., Amna Tariq Dr. Maryam Liaqat Dr. Mohammad Noman Khalid. "A CROSS-SECTIONAL RESEARCH TO ASSESS THE LVDD (LEFT VENTRICULAR DIASTOLIC DYSFUNCTION) IN COPD (CHRONIC OBSTRUCTIVE PULMONARY DISEASE) PATIENTS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 11 (2018): 11328–33. https://doi.org/10.5281/zenodo.1477629.

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<em>Objective: </em><em>Association amongst COPD and cardiovascular diseases intensely persist because diastolic dysfunction is generally diagnosed in patients with COPD’s problem. </em><em>The purpose of the conduct of </em><em>the study is to </em><em>decide about the existence of left ventricular diastolic dysfunction in patients of COPD.</em> <em>Material and Methods: R</em><em>elative study had conducted for a period of one year at Allied Hospital, Faisalabad (February to October 2017). In the study, the inclusion of confirmed 50 COPD’s patients was sort. Patients were examine

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Rolland, Pierre-Henri, Pascal de Lagausie, Euletheris Stathopoulos, et al. "Phasic hemodynamics and reverse blood flows in the aortic isthmus and pulmonary arteries of preterm lambs with pulmonary vascular dysfunction." American Journal of Physiology-Heart and Circulatory Physiology 295, no. 6 (2008): H2231—H2241. http://dx.doi.org/10.1152/ajpheart.00410.2008.

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Time-domain representations of the fetal aortopulmonary circulation were carried out in lamb fetuses to study hemodynamic consequences of congenital diaphragmatic hernia (CDH) and the effects of endothelin-receptor antagonist tezosentan (3 mg/45 min). From the isthmic aortic and left pulmonary artery (PA) flows (Q) and isthmic aortic, PA, and left auricle pressures (P) on day 135 in 10 controls and 7 CDH fetuses (28 ewes), discrete-triggered P and Q waveforms were modelized as P t and Q t functions to obtain basic hemodynamic profiles, pulsatile waves [P, Q, and entry impedance ( Ze)], and P a

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Pérez-Peñate, Gregorio Miguel, Iñigo Rúa-Figueroa, Gabriel Juliá-Serdá, et al. "Pulmonary Arterial Hypertension in Systemic Lupus Erythematosus: Prevalence and Predictors." Journal of Rheumatology 43, no. 2 (2015): 323–29. http://dx.doi.org/10.3899/jrheum.150451.

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Objective.Pulmonary arterial hypertension (PAH) prevalence has been reported to be between 0.5% and 17% in systemic lupus erythematosus (SLE). This study assessed PAH prevalence and predictors in an SLE cohort.Methods.The Borg dyspnea scale, DLCO, N-terminal pro–brain natriuretic peptide (NT-proBNP), and Doppler echocardiographic (DE) were performed. An echocardiographic Doppler exercise test was conducted in selected patients. When DE systolic pulmonary arterial pressure was ≥ 45 mmHg or increased during exercise > 20 mmHg, a right heart catheterization was performed. Hemodynamic during ex

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Kiefer, Todd L., and Thomas M. Bashore. "Pulmonary Hypertension Related to Left-Sided Cardiac Pathology." Pulmonary Medicine 2011 (2011): 1–11. http://dx.doi.org/10.1155/2011/381787.

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Pulmonary hypertension (PH) is the end result of a variety of diverse pathologic processes. The chronic elevation in pulmonary artery pressure often leads to right ventricular pressure overload and subsequent right ventricular failure. In patients with left-sided cardiac disease, PH is quite common and associated with increased morbidity and mortality. This article will review the literature as it pertains to the epidemiology, pathogenesis, and diagnosis of PH related to aortic valve disease, mitral valve disease, left ventricular systolic and diastolic dysfunction, and pulmonary veno-occlusiv

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Kuzubova, N. A., V. E. Perley, A. Yu Gichkin, E. A. Surkova, and E. Yu Lukina. "Effect of inhaled glucocorticosteroids on endothelial function and pulmonary and cardiac haemodynamics in patients with chronic obstructive pulmonary disease." PULMONOLOGIYA, no. 5 (October 28, 2007): 84–87. http://dx.doi.org/10.18093/0869-0189-2007-0-5-84-87.

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Chronic obstructive pulmonary disease (COPD) is one of important problems of public healthcare. The aim of the present study was to investigate effect of beclomethazone on endothelial function (endothelin-1 level and results of Celermajer's test) and ultrasound parameters of pulmonary and central circulation in 42 COPD patients. Endothelium dysfunction was found in 66% of patients. It improved after antiinflammatory treatment. The improvement in myocardial diastolic function and decrease in systolic pulmonary artery pressure were revealed after 3-month beclomethazone therapy.

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Textor, JA, NG Ducharme, RD Gleed, et al. "Effect of pericardiotomy on exercise-induced pulmonary hypertension in the horse." Equine and Comparative Exercise Physiology 3, no. 1 (2006): 45–51. http://dx.doi.org/10.1079/ecp200677.

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AbstractThe role of cardiac function or dysfunction in the pathogenesis of exercise-induced pulmonary hypertension and haemorrhage in horses has been minimally investigated. We hypothesize that pericardiotomy would enhance diastolic function and attenuate pulmonary vascular pressures in maximally exercising horses. Our objective was to evaluate diastolic function and cardiopulmonary pressures before and after pericardiotomy, at rest and at maximal exercise. Study design was both self- and externally controlled. Five horses underwent pericardiotomy after a baseline exercise test. They subsequen

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Ewert, Ralf, Alexander Heine, Annegret Müller-Heinrich, et al. "Exercise and fluid challenge during right heart catheterisation for evaluation of dyspnoea." Pulmonary Circulation 10, no. 3 (2020): 10.1177_2045894. http://dx.doi.org/10.1177/2045894020917887.

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This prospective study compared exercise test and intravenous fluid challenge in a single right heart catheter procedure to detect latent diastolic heart failure in patients with echocardiographic heart failure with preserved ejection function. We included 49 patients (73% female) with heart failure with preserved ejection function and pulmonary artery wedge pressure ≤15 mmHg. A subgroup of 26 patients had precapillary pulmonary hypertension. Invasive haemodynamic and gas exchange parameters were measured at rest, 45° upright position, during exercise, after complete haemodynamic and respirato

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Allison, John David, Carl Zehner, Xiaoming Jia, et al. "Assessing the Validity of Echocardiographic Criteria for Left Ventricular Diastolic Dysfunction in Patients with Pulmonary Hypertension." Cardiology 145, no. 11 (2020): 703–9. http://dx.doi.org/10.1159/000510348.

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<b><i>Background:</i></b> In patients with pulmonary hypertension (PHT), the assessment of left ventricular (LV) diastolic function by echocardiography may not be reliable. PHT can affect Doppler parameters of LV diastolic function such as mitral inflow velocities and mitral annular velocities. The current guidelines for the assessment of LV diastolic function do not recommend specific adjustments for patients with PHT. <b><i>Methods:</i></b> We analyzed 36 patients from the PHT clinic that had an echocardiogram and right heart catheterization pe

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Yim, Deane L. S., Bryn O. Jones, Peta M. A. Alexander, Yves d’Udekem, and Michael M. H. Cheung. "Effect of anti-heart failure therapy on diastolic function in children with single-ventricle circulations." Cardiology in the Young 25, no. 7 (2015): 1293–99. http://dx.doi.org/10.1017/s1047951114002376.

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AbstractBackgroundChildren with functionally univentricular circulations have chronic volume loading of the systemic ventricle, potentially affecting ventricular function. Medications including angiotensin-converting enzyme inhibitors and β-blockers are used to treat ventricular dysfunction, despite limited evidence of their efficacy in this population.ObjectiveTo determine the effects of angiotensin-converting enzyme inhibitors on elevated filling pressures in children with single ventricle physiology.MethodsWe performed a single-centre, retrospective review of patients with single ventricle

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Tang, Hong, Ziyin Dai, Miao Wang, et al. "Lumped-Parameter Circuit Platform for Simulating Typical Cases of Pulmonary Hypertensions from Point of Hemodynamics." Journal of Cardiovascular Translational Research 13, no. 5 (2020): 826–52. http://dx.doi.org/10.1007/s12265-020-09953-y.

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Abstract Pulmonary hypertension (PH) presents unusual hemodynamic states characterized by abnormal high blood pressure in pulmonary artery. The objective of this study is to simulate how the hemodynamics develops in typical PH cases without treatment. A lumped-parameter circuit platform of human circulation system is set up to simulate hemodynamic abnormalities of PH in different etiologies and pathogenesis. Four typical cases are considered, which are distal pulmonary artery stenosis, left ventricular diastolic dysfunction, ventricular septal defect, and mitral stenosis. The authors propose r

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Baev, V. M., and Т. Yu Agafonova. "Pathogenetic role of the autonomic nervous system in arterial hypotension cardiac remodeling in young women." Cardiovascular Therapy and Prevention 18, no. 1 (2019): 67–72. http://dx.doi.org/10.15829/1728-8800-2019-1-67-72.

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Aim. To study the features of cardiac remodeling on condition of the autonomic nervous system (ANS) in young women with idiopathic arterial hypotension (IAH).Material and methods. A comparative analysis of the echocardiography data in women with IAH aged 18-25 years with a predominance of sympathetic (n=150) and parasympathetic (n=60) parts of the ANS was performed. The level of systolic blood pressure ≤98 mm Hg worked as the criterion of IAH. The activity of the ANS was evaluated by the I. Kérdö index.Results. It has been shown that women with IAH with sympathicotonia are characterized by a s

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Reque, Javier, Ana Garcia-Prieto, Tania Linares, et al. "Pulmonary Hypertension Is Associated with Mortality and Cardiovascular Events in Chronic Kidney Disease Patients." American Journal of Nephrology 45, no. 2 (2016): 107–14. http://dx.doi.org/10.1159/000453047.

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Background: We evaluated the prevalence, determinants and prognosis value of pulmonary hypertension (PH) in non-dialysis chronic kidney disease (CKD) patients. Methods: This is a prospective study with stages 3-5 non-dialysis-dependent CKD patients. PH was estimated by Doppler echocardiography and defined as a pulmonary artery systolic pressure above 35 mm Hg. Results: Three hundred fifty-three patients were recruited, of whom 94 (26.6%) had PH. Prevalence of PH increased with the decline of renal function: 21.6, 24.1, and 31.7% in stages 3, 4, and 5, respectively. Independent predictors of PH

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Gold, Jonathan, Yohei Akazawa, Mei Sun, Kendall S. Hunter, and Mark K. Friedberg. "Relation between right ventricular wall stress, fibrosis, and function in right ventricular pressure loading." American Journal of Physiology-Heart and Circulatory Physiology 318, no. 2 (2020): H366—H377. http://dx.doi.org/10.1152/ajpheart.00343.2019.

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Right ventricle (RV) pressure loading can lead to RV fibrosis and dysfunction. We previously found increased RV, septal hinge-point and left ventricle (LV) fibrosis in experimental RV pressure loading. However, the relation of RV wall stress to biventricular fibrosis and dysfunction is incompletely defined. Rabbits underwent progressive pulmonary artery banding (PAB) over 3 wk with hemodynamics, echocardiography, and myocardial samples obtained at a terminal experiment at 6 wk. An additional group received PAB and treatment with an endothelin receptor antagonist. The endocardial and epicardial

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von Arx, Robert, Yves Allemann, Claudio Sartori, et al. "Right ventricular dysfunction in children and adolescents conceived by assisted reproductive technologies." Journal of Applied Physiology 118, no. 10 (2015): 1200–1206. http://dx.doi.org/10.1152/japplphysiol.00533.2014.

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Assisted reproductive technologies (ART) predispose the offspring to vascular dysfunction, arterial hypertension, and hypoxic pulmonary hypertension. Recently, cardiac remodeling and dysfunction during fetal and early postnatal life have been reported in offspring of ART, but it is not known whether these cardiac alterations persist later in life and whether confounding factors contribute to this problem. We, therefore, assessed cardiac function and pulmonary artery pressure by echocardiography in 54 healthy children conceived by ART (mean age 11.5 ± 2.4 yr) and 54 age-matched (12.2 ± 2.3 yr)

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McCabe, Colm, Paul A. White, Stephen P. Hoole, et al. "Right ventricular dysfunction in chronic thromboembolic obstruction of the pulmonary artery: a pressure-volume study using the conductance catheter." Journal of Applied Physiology 116, no. 4 (2014): 355–63. http://dx.doi.org/10.1152/japplphysiol.01123.2013.

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Pressure-volume loops describe dynamic ventricular performance, relevant to patients with and at risk of pulmonary hypertension. We used conductance catheter-derived pressure-volume loops to measure right ventricular (RV) mechanics in patients with chronic thromboembolic pulmonary arterial obstruction at different stages of pathological adaptation. Resting conductance catheterization was performed in 24 patients: 10 with chronic thromboembolic pulmonary hypertension (CTEPH), 7 with chronic thromboembolic disease without pulmonary hypertension (CTED), and 7 controls. To assess the validity of c

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Kamelia, Telly, Cleopas M. Rumende, Lukman H. Makmun, et al. "A novel diastolic dysfunction score: A proposed diagnostic predictor for left ventricular dysfunction in obese population." Narra J 5, no. 1 (2025): e1564. https://doi.org/10.52225/narra.v5i1.1564.

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Obesity-related diastolic dysfunction is an emerging contributor to heart failure and cardiovascular mortality. However, effective and accessible diagnostic tools are still limited. Current methods for assessing diastolic dysfunction are often invasive or technologically demanding, making them impractical for routine clinical use and community settings. The aim of this study was to develop a novel, non-invasive scoring system designed to predict diastolic dysfunction in obese adults, addressing this diagnostic gap. This community-based, prospective cross-sectional study was conducted in Jakart

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V Baroncini, Liz Andréa. "Right ventricle Outflow Tract Acceleration Time: Correlation with Left Ventricular Diastolic Function." Clinical Imaging and Interventional Radiology 3, no. 1 (2020): 01–05. http://dx.doi.org/10.31579/2642-1674/008.

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Background: There are no available data about the measurement of acceleration time at the right ventricle outflow tract (AcT) and its relevance in the analysis of the left ventricular diastolic function (LVDF). Objective: To correlate AcT with echocardiographic parameters of LVDF. Method: Eighty-seven patients (58.4±14.5 years; 52% women) submitted to transthoracic echocardiogram assessing spectral and tissue Doppler of the transmitral flow and mitral annulus, AcT, left atrial volume (LAV), and pulmonary artery systolic pressure (PASP). Patients with systolic dysfunction of the LV and grades I

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V Baroncini, Liz Andréa. "Research Article: Right ventricle Outflow Tract Acceleration Time: Correlation with Left Ventricular Diastolic Function." Carcinogenesis and Chemotherapy 1, no. 1 (2022): 01–06. https://doi.org/10.31579/2835-9216/001.

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Background: There is no available data about the measurement of acceleration time at the right ventricle outflow tract (AcT) and its relevance in the analysis of the left ventricular diastolic function (LVDF). Objective: To correlate AcT with echocardiographic parameters of LVDF. Method: Eighty-seven patients (58.4±14.5 years; 52% women) submitted to transthoracic echocardiogram assessing spectral and tissue Doppler of the transmitral flow and mitral annulus, AcT, left atrial volume (LAV), and pulmonary artery systolic pressure (PASP). Patients with systolic dysfunction of the LV and grades II

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Martín de Miguel, Irene, C. Charles Jain, Alexander C. Egbe, Donald J. Hagler, Heidi M. Connolly, and William R. Miranda. "Surgical Repair of Truncus Arteriosus: A Long-Term Hemodynamic Assessment." World Journal for Pediatric and Congenital Heart Surgery 13, no. 6 (2022): 716–22. http://dx.doi.org/10.1177/21501351221114779.

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Background: Unrepaired truncus arteriosus (TA) carries poor prognosis due to complications of unrestricted pulmonary flow, truncal valve insufficiency, and pulmonary vascular disease. Currently, the hemodynamic profile of adults late after TA repair is unknown. We reviewed the hemodynamics, prevalence, and pathophysiology of pulmonary hypertension (PH) in this population. Methods: Eighteen adult patients with repaired TA who underwent cardiac catheterization at Mayo Clinic, MN, between 1997 and 2021 were identified. PH was defined as either precapillary (mean pulmonary artery pressure [mPAP] ≥

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Teplinsky, K., M. O'Toole, M. Olman, K. R. Walley, and L. D. Wood. "Effect of lactic acidosis on canine hemodynamics and left ventricular function." American Journal of Physiology-Heart and Circulatory Physiology 258, no. 4 (1990): H1193—H1199. http://dx.doi.org/10.1152/ajpheart.1990.258.4.h1193.

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Hypoperfusion states cause lactic acidosis, and the acidemia further reduces the inadequate cardiac output. Conceivably, the adverse effect of lactic acidemia on cardiac output is due to depressed contractility demonstrated in isolated myocardium. Alternatively, factors governing venous return cause a relative hypovolemic state and/or acidemic pulmonary vasoconstriction-induced right ventricular dysfunction. We reasoned that examination of left ventricular pressure-volume relationships at end systole and end diastole would determine which of these potential mechanisms accounted for reduced car

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Fomina, Elena S., Elena S. Fomina, Viktor S. Nikiforov, Elena V. Frolova, and Dmitrii A. Reshetnik. "Left ventricular myocardial dysfunction and parameters of ambulatory blood pressure monitoring in patients with arterial hypertension and frailty." Consilium Medicum 23, no. 1 (2021): 80–83. http://dx.doi.org/10.26442/20751753.2021.1.200476.

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Aim. To study and analyze the systolic and diastolic left ventricle (LV) function, parameters of the ambulatory blood pressure (BP) monitoring in patients over 65 years of age with arterial hypertension, depending on the presence of frailty. Materials and methods. We examined 77 patients over 65 years of age (25 men and 52 women) with arterial hypertension, who were divided into two groups: with the presence of frailty (38 people) and its absence (39 people). To detect frailty, we used the "Age is not a hindrance" questionnaire validated in Russia and the "Get up and go" test. The examination

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Ahmed Mohammad Abbas, Hany Hussein Mousa, Reda biomy, Mohamed AbdelGhafar Hussein, Heba Mohammad Reyad, and Osama Elagamy. "Tissue doppler echocardiography as a predictor of early subclinical right ventricular diastolic dysfunction in asthmatic children." Journal of the Pakistan Medical Association 73, no. 4 (2023): S151—S155. http://dx.doi.org/10.47391/jpma.egy-s4-31.

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Objective: To assess the effect of asthma in children on systolic and diastolic functions of the heart, and to explore the relationship between the two.Methods: The case-control study was conducted at Kafrelsheikh University Hospital, Egypt, from September 2019 to May 2022, and comprised asthmatic children of either gender aged 5-15 years and healthy controls matched for age and gender. The participants were subjected to detailed history, complete examination, spirometry evaluation and conventional and tissue Doppler echocardiography. Myocardial performance index was calculated and compared. D

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Borgdorff, Marinus A., Beatrijs Bartelds, Michael G. Dickinson, et al. "Sildenafil treatment in established right ventricular dysfunction improves diastolic function and attenuates interstitial fibrosis independent from afterload." American Journal of Physiology-Heart and Circulatory Physiology 307, no. 3 (2014): H361—H369. http://dx.doi.org/10.1152/ajpheart.00843.2013.

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Right ventricular (RV) function is an important determinant of prognosis in congenital heart diseases, pulmonary hypertension, and heart failure. Preventive sildenafil treatment has been shown to enhance systolic RV function and improve exercise capacity in a model of fixed RV pressure load. However, it is unknown whether sildenafil has beneficial effects when treatment is started in established RV dysfunction, which is clinically more relevant. Our aim was to assess the effects of sildenafil treatment on RV function and fibrosis in a model of established RV dysfunction due to fixed afterload.

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Braksator, Marta, Magdalena Jachymek, Karina Witkiewicz, et al. "The Impact of Left Ventricular Diastolic Dysfunction on Respiratory Adverse Events in Cardiac Surgery Patients—An Observational Prospective Single-Center Study." Journal of Clinical Medicine 12, no. 15 (2023): 4960. http://dx.doi.org/10.3390/jcm12154960.

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Background: Left ventricular diastolic dysfunction (LV DD) is the most dominant cause of heart failure with preserved ejection fraction (HFpEF) worldwide. This pathological condition may contribute to postcapillary pulmonary hypertension (pcPH) development. Hypoxemia, often observed in pcPH, may significantly negatively impact the course of hospitalization in patients after cardiac surgery. The aim of our study was to investigate the impact of LV DD on the frequency of postoperative respiratory adverse events (RAE) in patients undergoing Coronary Artery Bypass Grafting (CABG). Methods: The lef

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Aidargalieva, N. E., and A. Zh Teleusheva. "Features of intracardiac hemodynamics disoders in patients with chronic obstructive pulmonary disease complicated by the chronic pulmonary heart disease development and methods for their medical correction." Kazan medical journal 97, no. 3 (2016): 400–404. http://dx.doi.org/10.17750/kmj2016-400.

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Chronic pulmonary heart disease is a common pathology and has become one of the leading causes of disability and death in recent years [15]. According to the literature, two-thirds of patients with chronic obstructive pulmonary disease die during the period from 15 months to 5 years after the circulatory decompensation onset, which occupies the third place after hypertension and coronary heart disease among causes of death in the age group older than 50 years [14]. Pulmonary hypertension is considered to be the main pathogenetic mechanism of chronic pulmonary heart disease [11]. The mortality

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Vontetsianos, Angelos, Nikolaos Chynkiamis, Maria Gounaridi, et al. "Exercise Intolerance Is Associated with Cardiovascular Dysfunction in Long COVID-19 Syndrome." Journal of Clinical Medicine 13, no. 14 (2024): 4144. http://dx.doi.org/10.3390/jcm13144144.

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Background/Objectives: Cardiorespiratory complications are commonly reported among patients with long COVID-19 syndrome. However, their effects on exercise capacity remain inconclusive. We investigated the impact of long COVID-19 on exercise tolerance combining cardiopulmonary exercise testing (CPET) with resting echocardiographic data. Methods: Forty-two patients (55 ± 13 years), 149 ± 92 days post-hospital discharge, and ten healthy age-matched participants underwent resting echocardiography and an incremental CPET to the limit of tolerance. Left ventricular global longitudinal strain (LV-GL

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Castro, Oswaldo, Adriana Medina, and Peter Gaskin. "Normal Pulmonary Artery Pressure in Sickle Cell Patient with Severe Iron Deficiency Anemia." Blood 108, no. 11 (2006): 3785. http://dx.doi.org/10.1182/blood.v108.11.3785.3785.

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Abstract One-third of adults with sickle cell disease (SCD) have echocardiographic (ECHO) evidence of pulmonary hypertension (PHTN), a complication associated with early mortality. Because the pulmonary artery pressures in most SCD patients with PHTN are only mildly elevated, the question arises whether such increases are primarily a reflection of the high cardiac output state that accompanies the anemia. Recently we treated a 45 year-old woman with homozygous sickle-cell disease and profound iron deficiency due to heavy menstrual flow. Two ECHOs were done while she was severely iron deficient

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