Relevant bibliographies by topics / Diastolic function of the left ventricle

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Academic literature on the topic 'Diastolic function of the left ventricle'

Author: Grafiati
Published: 4 June 2025
Last updated: 23 June 2025

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Journal articles on the topic "Diastolic function of the left ventricle"

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V Baroncini, Liz Andréa. "Right ventricle Outflow Tract Acceleration Time: Correlation with Left Ventricular Diastolic Function." Clinical Imaging and Interventional Radiology 3, no. 1 (2020): 01–05. http://dx.doi.org/10.31579/2642-1674/008.

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Background: There are no available data about the measurement of acceleration time at the right ventricle outflow tract (AcT) and its relevance in the analysis of the left ventricular diastolic function (LVDF). Objective: To correlate AcT with echocardiographic parameters of LVDF. Method: Eighty-seven patients (58.4±14.5 years; 52% women) submitted to transthoracic echocardiogram assessing spectral and tissue Doppler of the transmitral flow and mitral annulus, AcT, left atrial volume (LAV), and pulmonary artery systolic pressure (PASP). Patients with systolic dysfunction of the LV and grades II and III diastolic dysfunction (DD) were excluded. Main analyses were performed using the Spearman’s Correlation Coefficient (SCC) and Pearson’s Linear Correlation Coefficient (PLCC). Results: A negative correlation between AcT value and age (PLCC – 0.36; Student’s t-test; p <0.001) and a positive correlation between AcT and E/A ratio (SCC 0.38; p<0.001), between AcT and E/e’ ratio (SCC 0.26; p=0.01), between AcT and E wave of the mitral flow (PLCC 0.36; p= 0.001) were found. LAV and PASP did not correlate with AcT. In patients with a normal diastolic function, AcT was higher when compared with the AcT in patients with Grade I DD (0.150±0.029ms versus 0.127±0.023ms; p<0.001; Student’s t-test). The threshold suggested in this subgroup of patients was 0.135s. Conclusions: The present study correlated, unprecedentedly, AcT with echocardiographic parameters of the LV diastolic function. AcT values lower than 0.135s were associated with grade I diastolic dysfunction and higher than 0.135s values were associated with normal diastole.
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Spaska, G. "Heart left ventricle’s diastolic function features in patients with reactive arthritis." Likarska sprava, no. 3 (May 29, 2013): 56–58. http://dx.doi.org/10.31640/ls-2013-3-09.

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Cross-correlation analysis’s data indicate for the patients with reactive arthritis features, which determine character the left ventricle’s diastolic filling, are end-diastolic pressure and end-diastolic pressure / end-diastolic volume index in the left ventricle.
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WRANNE, B., and G. SUTHERLAND. "DIASTOLIC FUNCTION OF THE LEFT VENTRICLE." Echocardiography 15, no. 8-2 (1998): S74—S75. http://dx.doi.org/10.1111/j.1540-8175.1998.tb00976.x.

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Kuznetsova, V. V., and A. V. Bursikov. "Diastolic function left ventricle in a debut of revealing of hypertonic illness at young age." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 13, no. 4 (2007): 292–94. http://dx.doi.org/10.18705/1607-419x-2007-13-4-292-294.

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The purpose: To estimate diastolic function left ventricle at persons of young age with recently revealed arterial hypertension and to reveal early attributes of its infringement. Materials and methods: On device LOGIQ 500 method Doppler echocardiography studies diastolic function left ventricle at 34 patients of young age with prescription of revealing arterial hypertension no more than 3 years and practically healthy 48 persons. Results: At an arterial hypertension already in a debut of revealing of disease change of some Doppler echocardiography parameters diastolic fillings left ventricle takes place: decrease in high-speed parameters early diastolic fillings and increase in peak speed and fraction of late filling left ventricle, that reflects difficulty of filling left ventricle and increased hemodinamic loading on the left auricle. The conclusion: Changes of speeds diastolic fillings left ventricle reflects its structurally functional remodeling and can be used as criterion of diagnostics of defeat of heart at arterial hypertension
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Solomon, Steven B., Srdjan D. Nikolic, Stanton A. Glantz, and Edward L. Yellin. "Left ventricular diastolic function of remodeled myocardium in dogs with pacing-induced heart failure." American Journal of Physiology-Heart and Circulatory Physiology 274, no. 3 (1998): H945—H954. http://dx.doi.org/10.1152/ajpheart.1998.274.3.h945.

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In patients with heart failure, decreased contractility resulting in high end-diastolic pressures and a restrictive pattern of left ventricular filling produces a decrease in early diastolic filling, suggesting a stiff ventricle. This study investigated the elastic properties of the myocardium and left ventricular chamber and the ability of the heart to utilize elastic recoil to facilitate filling during pacing-induced heart failure in the anesthetized dog. Elastic properties of the myocardium were determined by analyzing the myocardial stress-strain relation. Left ventricular chamber properties were determined by analyzing the pressure-volume relation using a logarithmic approach. Elastic recoil was characterized using a computer-controlled mitral valve occluder to prevent transmitral flow during diastole. We conclude that, during heart failure, the high end-diastolic pressures suggestive of a stiff ventricle are due not to stiffer myocardium but to a ventricle whose chamber compliance characteristics are changed due to geometric remodeling of the myocardium. The restrictive filling pattern is a result of the ventricle being forced to operate on the stiff portion of the diastolic pressure-volume relation to maintain cardiac output. Slowed relaxation and decreased contractility result in an inability of the heart to contract to an end-systolic volume below its diastolic equilibrium volume. Thus the left ventricle cannot utilize elastic recoil to facilitate filling during heart failure.
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Koshlya, V. I., O. S. Kulbachuk, N. P. Sklyarova, A. V. Piskun, and O. V. Solovyov. "Changes of the diastolic function of left ventry in patients with arterial hypertension in the process of micardis treatment in the family doctor's conditions." Modern medical technologies 40, no. 1 (2019): 45–47. http://dx.doi.org/10.34287/mmt.1(40).2019.7.

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Among 38 patients with arterial hypertension I and II degree, the diastolic function of the left ventricle was studied in the course of a twelve-month treatment with Telmisartan (Micardis). Analysis of the diastolic function of the left ventricle before the treatment with telmisartan showed that in both groups of patients with respect to the control group there was a significant decrease in the maximum speed of early diastolic filling and an increase in the maximum rate of atrial filling with increasing severity of the disease.At the same time, the period of isovolumetric relaxation and the end diastolic pressure in the left ventricle increased, and the E/A and Ei/Ai ratios tended to decrease. At the end of the 12-month period of treatment with micardis, the achievement of target levels of blood pressure and normalization of diastolic function of the left ventricle were noted. Keywords: arterial hypertension, left ventricular diastolic dysfunction, micardis.
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Shveс, D. A., and S. V. Povetkin. "The Role of Residual Stenosis of the Coronary Arteries in the Dynamics Systolicdiastolic Left Ventricular Function after Acute Coronary Syndrome." Kardiologiia 60, no. 2 (2020): 33–40. http://dx.doi.org/10.18087/cardio.2020.2.n853.

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Objective. The aim of the research under consideration was to study the dynamics of a local systolic-diastolic function of patients with various ischemic heart disease (IHD) progressions after survival of an acute coronary syndrome (ACS) provided there are residual stenoses of coronary arteries.Materials and Methods. There were 112 patients suffering from ACS who took part in the research. The diagnosis was verified (acute myocardial infarction or unstable angina) in accordance with the recommendations of European Society of Cardiology (ESC). All patients were divided into two groups depending on the occurrence of major acute cardiac events (MACE): 59 patients with aggravated IHD progression and 152 patients with non-aggravated course. Echo-cardiography was performed on a scanner Philips iE33 (the Netherlands) with a consideration to systolic and diastolic functions parameters of a left ventricle. Quantitative analysis of the left ventricle was executed in the mode of Tissue Doppler Imaging (TDI) and according to the method of tracing the patches of the ultra-sound image gray scale (ST).Results. In the course of the aggravated IHD a decrease in systolic-diastolic function of left ventricle has been discovered. It has been found out that the amount of the systolic peak of longitudinal strain of the left ventricle anteroseptal wall less than 12% is associated with a greater extent of coronary atherosclerosis and aggravated progression of IHD. TDI and ST methods have enabled to reveal that in the course of non-aggravated IHD the contractility and the diastolic function of the left ventricle anteroseptal wall improve in combination with the increase in the contractility of the left ventricle inferolateral wall. During an aggravated IHD progression the contractility and diastolic function of the left ventricle anteresoptal wall decreases without an increase in contractility and diastolic function of the inferior and inferolateral walls of the left ventricle. The reason for such results might be a progressing myocardial ischemia of the left ventricle anteroseptal wall despite the sufficient anterior interventricular artery stenting. The presence of the relevant residual stenoses of the circumflex and right coronary arteries increases the possibility of the aggravated IHD progressing especially by the end of the fourth year of observation.Conclusion. The disbalance of the local contractility of anterior, inferior and inferolateral left ventricle walls in the course of aggravated IHD is connected with the CA residual stenoses presence and forwards the decrease in global systolic-diastolic function of the left ventricle. The final results can serve as a foundation for optimization of recommendations for performing PCI on the patients with multivessel disease of CA.
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Deljanin-Ilic, Marina, Stevan Ilic, Dragan Djordjevic, Marija Zdravkovic, and Vladimir Ilic. "Evaluation of myocardial function in the presence of left ventricular hypertrophy in athletes and hypertensive patients." Medical review 61, no. 3-4 (2008): 178–82. http://dx.doi.org/10.2298/mpns0804178d.

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Introduction Myocardial hypertrophy of the left ventricle may be of physiological or pathological nature. Distinction of these two types of hypertrophy is sometimes not easy and represents a diagnostic challenge. The aim of the study was to assess global diastolic and regional systolic and diastolic myocardial function in the presence of left ventricular hypertrophy in athletes and hypertensive patients. Material and methods In 18 male hypertensive patients and 14 male athletes global diastolic left ventriclar function and regional systolic and diastolic myocardial function of septum and posterior wall were investigated by pulsed wave tissue Doppler imaging. Results Ejection fraction and left ventricle mass index did not differ significantly between two groups. Hypertensive patients were found to have diastolic dysfunction while athletes had normal left ventricular diastolic function (the difference between the groups was P<0.00001). Index of regional diastolic function of septum as well as of the posterior wall was significantly less in hypertensive patients than in athletes (P<0.00001 for both). In spite of the normal global systolic function the regional systolic function of septum and posterior wall was significantly less in hypertensive patients than in athletes (P<0.02for both). Conclusion The present results show significantly less global and regional diastolic function of hypertrophied myocardium in hypertensive patients than in athletes. In the presence of preserved left ventricular systolic function, the quantification of myocardial velocity revealed significantly lower regional systolic function of septum and posterior wall in hypertensive patients than in athletes.
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Yao, Shifa, Tian Yang, Xiaoxiao Kong, Yuanyuan Dang, Ping Chen, and Mingli Lyu. "The Influence of Maternal Condition on Fetal Cardiac Function during the Second Trimester." Diagnostics 13, no. 17 (2023): 2755. http://dx.doi.org/10.3390/diagnostics13172755.

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Objective: Maternal health has a direct, profound and lasting effect on the formation and development of the fetal cardiovascular system. The aim of this research was to find whether maternal age, BMI hypertension (GH) or gestational diabetic mellitus (GDM) would affect fetal cardiac function in the second trimester. Method: 329 mothers who had a fetal echocardiogram examination at the International Peace Maternity & Child Health Hospital of China Welfare Institute, Shanghai, China, from 1 January 2020 to 30 April 2020 were enrolled at the gestational age of 21 to 26 weeks (mean 22.78 ± 1.13 weeks). Single-factor analysis and multi-factor line regression analysis were used to find the contribution values of each factor to fetal cardiac function. Results: at the second trimester, maternal age had a minor influence on the fetal left ventricle diastolic function. Higher maternal BMI could cause a decrease in the fetal diastolic function of both the left and right ventricle and the systolic function of the left ventricle. Maternal hypertension and gestational diabetic mellitus had a profound influence on both the left and right fetal heart ventricles of both systolic and diastolic function. Conclusion: maternal condition will have a profound influence on fetal cardiac function as early as the second trimester.
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Vysotskaya, N. V., V. V. Lee, N. Yu Timofeeva, V. S. Zadionchenko, and T. V. Adasheva. "THE ASSOCIATION BETWEEN INTRACARDIAC HEMODYNAMICS AND LUNG FUNCTION IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE." Russian Archives of Internal Medicine 9, no. 5 (2019): 373–81. http://dx.doi.org/10.20514/2226-6704-2019-9-5-373-381.

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Study objective. To assess the association between intracardiac hemodynamics and airway obstruction with pulmonary hyperinflation in patients with chronic obstructive pulmonary disease.Materials and methods. Ninety-six patients with chronic obstructive pulmonary disease, aged 40 to 75 years, without concomitant cardiovascular disease, were examined and divided into 4 groups according to the severity of the disease. The patients underwent general clinical examination, spirometry, 24-hour pulse oximetry and echocardiography with assessment of linear and volumetric parameters, as well as diastolic function of left and right ventricles.Results. Linear and volumetric parameters of the left ventricle, LV myocardial mass and geometry in the examined patients with chronic obstructive pulmonary disease matched threshold values. The progression of the severity of chronic obstructive pulmonary disease was accompanied by decrease of the end-diastolic size of the left ventricle, ratio of peak early to late diastolic filling velocity for the left ventricle (E/A) without significant changes in the left ventricle isovolumetric relaxation time (IVRT). Moderate correlations of the inspiratory capacity with the end-diastolic size of the left ventricle (r=0.612; p=0.001) and the left ventricle E/A (r=0.464; p=0.001); forced expiratory volume in 1 second (FEV1) with the left ventricle E/A (r=0.600; p=0.011) were established. As a result of the logistic regression performed, the predictor value of the inspiratory capacity was confirmed (Wald χ2 — 5.795; р=0.024). Impairment of left ventricular diastolic function of grade I was revealed in 12 (31.6 %) patients in group 2, in 7 (24.1 %) patients in group 3, and in 9 (56.2 %) patients in group 4.Conclusion. Airway obstruction severity and pulmonary hyperinflation progression in patients with chronic obstructive pulmonary disease and without concomitant cardiovascular disease is associated with a decrease of left ventricular size and diastolic filling, contributes to the development of the left ventricular diastolic dysfunction, predominantly due to the decrease in filling velocity parameters.
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Dissertations / Theses on the topic "Diastolic function of the left ventricle"

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Meyers, Brett Albert. "Feasibility of Echocardiographic Particle Image Velocimetry for evaluation of cardiac left ventricular filling function." Thesis, Virginia Tech, 2014. http://hdl.handle.net/10919/78159.

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Heart disease is one of the primary causes of morbidity and mortality for the adult population over the age of 65. Furthermore, ailments such as hypertension can affect as many as 50% of the adult population over the age of 45. If left untreated, these ailments eventually precipitate the onset of diastolic dysfunction and heart failure. Diastolic dysfunction is the alteration or impairment of performance in either the left or right ventricle of the heart. Although there has been a marked increase in study of this disease, there is still an apparent difficulty to diagnose patients. Flow visualization techniques have been commonly employed to study the development of these diseases as they relate to the filling process of the ventricles. One method, Echo Particle Image Velocimetry (Echo-PIV) is a relatively new method for cardiac flow chamber visualization, with the potential to provide physicians with a cost-effective and safe method for obtaining high temporal resolution recordings for extending knowledge on the filling processes in cardiac chamber flow. This work presents a new approach to extending the capabilities of Echo-PIV for more accurate measurement of cardiac flows for patients with poor quality recordings. Currently, much of the literature notes that temporal resolution and poor acoustic windows results in exclusion from study. These recordings are more representative of the contrast-enhancement studies used by physicians to better identify chamber walls. When applying standard PIV cross-correlation techniques, measurements tend to fail due to image noise and artifacts. By implementing a Moving Ensemble (MWE) with Product of Correlation (PoC) processing scheme, measurement accuracy, reliability, and robustness can be obtained for measurement in left ventricular filling assessment.<br>Master of Science
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Koh, Carline, and 許上冕. "Effects of right ventricular pacing and its interruption on left ventricular torsional mechanics and diastolic function in congenitalheart block." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45167199.

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Guzzoni, Vinicius. "Remodelamento da matriz extracelular e respostas cardíacas funcionais em ratos idosos submetidos a treinamento resistido." Universidade Federal de São Carlos, 2016. https://repositorio.ufscar.br/handle/ufscar/7766.

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Submitted by Luciana Sebin (lusebin@ufscar.br) on 2016-09-28T12:49:43Z No. of bitstreams: 1 TeseVG.pdf: 16725561 bytes, checksum: 4a535b068b4ee7e66f0e74094c0f1ed0 (MD5)<br>Approved for entry into archive by Marina Freitas (marinapf@ufscar.br) on 2016-10-10T18:43:03Z (GMT) No. of bitstreams: 1 TeseVG.pdf: 16725561 bytes, checksum: 4a535b068b4ee7e66f0e74094c0f1ed0 (MD5)<br>Approved for entry into archive by Marina Freitas (marinapf@ufscar.br) on 2016-10-10T18:43:12Z (GMT) No. of bitstreams: 1 TeseVG.pdf: 16725561 bytes, checksum: 4a535b068b4ee7e66f0e74094c0f1ed0 (MD5)<br>Made available in DSpace on 2016-10-10T18:43:24Z (GMT). No. of bitstreams: 1 TeseVG.pdf: 16725561 bytes, checksum: 4a535b068b4ee7e66f0e74094c0f1ed0 (MD5) Previous issue date: 2016-03-04<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>INTRODUCTION: It is well documented that aging causes morphological and functional alterations in the heart. Cardiac ECM remodeling is one event of structural changes in left ventricle (LV), which is modulated by MMPs/TIMPs balance and may lead to cardiac fibrosis. To prevent such effects inherent of aging, aerobic exercise training has been suggested to improve the cardiac fibrosis and function. However the effects of resistance training (RT) remains unclear. Whether that RT could alter cardiac function following cardiac ECM remodeling is uncertain. PURPOSE: to investigate the chronic effects of high intensity resistance training (RT) in the extracellular matrix (ECM) remodeling of left ventricle (LV) and cardiac function in old rats. PROCEDURES: Rats with 3 and 21 months-age were assigned as young sedentary (YS), young trained (YT), old sedentary (OS) and old trained (OT). The trained groups (YT and OT) were submitted to high-intensity RT protocol (3 times a week during 12 weeks). After 48h post-training, hemodynamic and intra-ventricular pressures were recorded. LV myocyte width, LV connective tissue and collagen fibrils were analyzed. MMP-2 activity, gene and protein expression from ECM components as well as angiotensin II (Ang-II) and atrial natriuretic peptide (ANP) were evaluated FINDINGS: LV myocyte width and connective tissue were reduced in OT rats. RT increased the MMP-2 activity in OT rats and improved the agerelated increase in the left ventricle end diastolic pressure (LVEDP). The RT unchanged Ang-II and ANP in LV of old rats. CONCLUSION: RT was effective to decrease LV connective tissue, which was associated with increased ECM remodeling by MMP-2 activity in LV tissue and improvement of LVEDP in aging rats. Our results point out the importance of RT in ECM homeostasis and diastolic function in experimental aging model.<br>INTRODUÇÃO: O remodelamento da matriz extracelular (MEC) cardíaca é um evento dentre estas mudanças estruturais no ventrículo esquerdo (VE) que é orquestrado pelos níveis de metaloproteinases (MMP) e seus inibidores endógenos (TIMPs). Na tentativa de prevenir tais efeitos decorrentes da idade avançada, o exercício aeróbico tem sido sugerido por melhorar a fibrose e a função cardíaca. Entretanto, os efeitos do treinamento resistido (TR) nestas variáveis necessitam de melhor compreensão. OBJETIVO: investigar os efeitos crônicos do TR de alta intensidade na MEC do VE e a função cardíaca em ratos idosos. METODOLOGIA: ratos de 3 e 21 meses de idade foram designados como grupos: jovem sedentário (YS), jovem treinado (YT), idoso sedentário (OS) e idoso treinado (OT). Os grupos treinados foram submetidos à um protocolo de 12 semanas de escalada sob alta intensidade, 3 vezes por semana. Decorridos 48h pós última sessão de treino, medidas hemodinâmicas foram registradas: pressão arterial sistólica (SAP), pressão arterial diastólica (DAP), pressão arterial média (MAP), frequência cardíaca (HR), constante de decaímento da pressão ventricular (Tau), derivada temporal positiva da pressão intraventricular (+d P/dt), razão de decaímento da pressão ventricular (-dP/dt), pressão arterial sistólica máxima do VE (LVSP) e pressão arterial diastólica final do VE (LVEDP). Largura dos cardiomiócitos, % de tecido conectivo e de colágeno intersticial foram analisados no VE. A atividade da MMP-2 foi detectada por zimografia, assim como a expressao gênica e proteica de alguns constituintes da MEC. Moduladores da hipertrofia e fibrose cardíaca, angiotensina II (Ang-II) e peptídeo natriurético atrial (ANP) foram avaliados. RESULTADOS: a largura do cardiomiócito e a concentração de colágeno diminuíram em ratos OT comparados ao grupo OS. TR aumentou a atividade da MMP-2 e atenuou os aumentos na LVEDP de ratos idosos. Ratos OT não apresentaram alterações significativas na expressão dos elementos da MEC e nos peptídeos cardíacos Ang-II e ANP. O TR diminuiu significativamente a expressão gênica elevada de TIMP-1, TGF-β e COL-1, observados no grupo OS. CONCLUSÃO: o TR foi eficaz em diminuir o colágeno cardíaco o que pode ser associado com a melhora na função diastólica, o que pode estar relacionado com o aumento na atividade da MMP-2 em VE de ratos idosos. O TR atenuou a via de sinalização TGF-β–TIMP-1–COL-1, a nível transcricional. Portanto este estudo revela a importância do treinamento resistido na homesostase da MEC e melhora da função diastólica em modelo experimental de idoso.
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Niebel, Casandra L. "Dispersive Characteristics of Left Ventricle Filling Waves." Thesis, Virginia Tech, 2013. http://hdl.handle.net/10919/19249.

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Left ventricular diastolic dysfunction (LVDD) is any abnormality in the filling of the left ventricle (LV).  Despite the prevalence of this disease, it remains difficult to diagnose, mainly due to inherent compensatory mechanisms and a limited physical understanding of the filling process.  LV filling can be non-invasively imaged using color m-mode echocardiography which provides a spatio-temporal map of inflow velocity.  These filling patterns, or waves, are conventionally used to qualitatively assess the filling pattern, however, this work aims to physically quantify the filling waves to improve understanding of diastole and develop robust, reliable, and quantitative parameters.  <br />This work reveals that LV filling waves in a normal ventricle act as dispersive waves and not only propagate along the length of the LV but also spread and disperse in the direction of the apex.  In certain diseased ventricles, this dispersion is limited due to changes in LV geometry and wall motion.  This improved understanding could aid LVDD diagnostics not only for determining health and disease, but also for distinguishing between progressing disease states.<br />This work also indentifies a limitation in a current LVDD parameter, intra ventricular pressure difference (IVPD), and presents a new methodology to address this limitation.  This methodology is also capable of synthesizing velocity information from a series of heartbeats to generating one representative heartbeat, addressing inaccuracies due to beat-to-beat variations.  This single beat gives a comprehensive picture of that specific patient\'s filling pattern.  Together, these methods improve the clinical utility of IVPD, making it more robust and limiting the chance for a misdiagnosis.    <br /><br>Master of Science
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Müller-Brunotte, Richard. "Diastolic heart function in hypertension-induced left ventricular hypertrophy /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-898-3/.

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Clarkson, Peter Bruce Mark. "Studies of left ventricular diastolic function inhealth and disease." Thesis, University of Dundee, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337397.

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斎藤, 英彦, 博史 林, 和彦 宮口, et al. "Discrepancy between systolic and diastolic dysfunction of the left ventricle in patients with Duchenne muscular dystrophy." Thesis, Oxford University Press, 1993. http://hdl.handle.net/2237/16373.

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Zanaboni, Jacopo. "Left atrial conduit function: a Janus two-faced diastolic, powerful parameter." Doctoral thesis, Università del Piemonte Orientale, 2022. http://hdl.handle.net/11579/144262.

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Heart failure (HF) is a frequent clinical condition in which the heart cannot guarantee an adequate cardiac output, or it can do that at the cost of increasing intra-cardiac pressures, causing symptoms, reduced quality of life and poor prognosis. Left atrial (LA) function has an underappreciated role in HF pathophysiology. Aim: to assess if a larger LA conduit contribution to the left ventricular (LV) filling was associated with a heavier pulmonary haemodynamic burden, and, consequently, with a reduced patients’ functional capacity and worse survival. Methods: 60 HF patients (67 ± 11 years, ejection fraction 39 ± 11%, range 20-62%) underwent 6 minute walk test (6MWT) and 3D transthoracic echocardiography. LA conduit was computed off-line,gathering simultaneous real-time 3D multibeats (six cycles)LA and LV volume curves, with conduit (time) = [LV volume(time) - LV minimum volume] - [LA maximum volume - LA volume(time)], and expressed as % LV stroke volume. Atrial stiffness (Kla) was computed using noninvasively assessed wedge pressure divided by LA reservoir (maximum - minimum) volume. Pulmonary arterial compliance (PAC), representing the pulsatile component of right ventricular (RV) afterload wasobtained as the ratio between RV stroke volume and noninvasively estimated pulmonary pulse pressure. Results: Conduit averaged 34±12%, PAC 3.1±1.1 ml/mmHg, 6MWT 404±154 m. Conduit was independent of LV volumes and ejection fraction, showing a direct dependence on noninvasive Kla (r=0.56; P <0.001). Dividing patients into tertiles according to 6MWT and to PAC, the largest conduit fraction was associated with the lowest functional capacity (P<0.001) and most deranged PAC (P<0.001), respectively, suggesting outmost RV haemodynamic burden. Tertiles of conduit predicted survival (P=0.01). Conclusion: conduit depends on Kla and appears to be increased in heart failure patients with lowest capacity and worst survival, likely as RV pulsatile afterload, as reflected by PAC, is highest in these individuals.
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Bilal, Dejan. "Evaluation of systolic and diastolic left ventricular function during exercise in athletes." Thesis, Malmö universitet, Fakulteten för hälsa och samhälle (HS), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-25669.

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Idrottshjärta är ett kardiovaskulärt tillstånd som uppträder under längre perioder av intensiv träning som orsakar strukturella, funktionella och elektriska förändringar hos hjärtat och är en fysiologisk anpassning som svar på ett ökat hemodynamiskt behov under fysisk ansträngning. De fysiologiska anpassningarna har dock blivit ett diagnostiskt dilemma att urskilja från de patologiska förändringarna såsom hypertrofisk kardiomyopati. Det finns därför ett behov av standardisering av kardiovaskulär screening hos idrottare för att upptäcka underliggande eller dolda kardiomyopatier som kan leda till allvarliga konsekvenser under fysisk ansträngning. Studiens ändamål var att undersöka den systoliska och diastoliska vänsterkammarfunktionen under ansträngning hos idrottare och öka förståelsen om vad som händer med de olika variablerna under arbete. Nio friska idrottare genomförde stressekokardiografi där cardiac index, ejektionsfraktion, fyllnadstryck, mitralisklaffplanets longitudinella rörelse (MAPSE), mitralisinflöde, vävnadsdoppler (e´ och s´) och veninflöde undersöktes före, under och efter ett ansträngningstest på ergometercykel. Variablerna under och efter cykeltestet jämfördes sedan med värdena i vila. Resultaten visade en signifikant ökning av cardiac index, MAPSE och vävnadsdoppler under ansträngning. Sammanfattningsvis visade studien att flera av variablerna förbättrades under ansträngning och en del av de visade sig vara relativt okänsliga för störningar och artefakter vilket kan vara användbart för framtida studie protokoll som avser utföra en hjärtstudie under arbete.<br>Athlete’s heart is a cardiovascular condition that occurs during extended periods of intense exercise that causes structural, functional and electrical changes of the heart and is a physiological adaptation in response to increased hemodynamic needs during physical exertion. However, the physiological adaptations have become a diagnostic dilemma to distinguish from the pathological changes such as hypertrophic cardiomyopathy. Therefore, there is a need for standardization of cardiovascular screening in athletes to detect underlying or hidden cardiomyopathies that can lead to severe consequences during physical exercise. The aim of the present study was to investigate the systolic and diastolic left ventricular function during exercise in athletes and to increase the understanding of what happens to the various variables during exertion. Nine healthy athletes conducted stress echocardiography where cardiac index, ejection fraction, filling pressure, mitral annular plane systolic excursion (MAPSE), mitral inflow, tissue Doppler imaging (e 'and s') and pulmonary venous inflow were examined before, during and after a cycle ergometer test. The variables during and after the cycle test were then compared to baseline. The results showed a significant increase in cardiac index, MAPSE, and tissue Doppler imaging during exertion. In conclusion, the study showed that several of the variables improved during exertion and some of them proved to be quite insensitive to disturbances and artifacts, which may be useful in future study protocols that consider carrying out a cardiac study during work.
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Fonseca, Carissa Grace. "Assessment of left ventricular diastolic function with three dimensional cardiac magnetic resonance imaging." Thesis, University of Auckland, 2004. http://hdl.handle.net/2292/5715.

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Measurement of diastolic left ventricular (LV) function is vitally important in the assessment of cardiac disease. However, only limited information on tissue function can be obtained with current clinical techniques. This Thesis developed and investigated novel parameters of both global and regional myocardial function, using cardiac magnetic resonance imaging (MRI) with three-dimensional tissue tagging. Multidirectional peak myocardial shortening strains and strain rates, as well as the peak systolic displacement and velocity of the mitral valve annulus plane (MVP), were considered as parameters of LV systolic function. The corresponding peak diastolic strain relaxation rates and peak diastolic MVP velocity were used to assess diastolic function. The effects of normal ageing were studied in people with no evidence of cardiac disease, and compared with the effects of disease in patients with type 2 diabetes mellitus (DM). In normal healthy subjects, systolic strain parameters were preserved, while diastolic parameters were impaired, with age. DM patients showed impaired diastolic function on correction for age, and systolic functional parameters were also impaired, even though LV ejection fraction was normal. MVP systolic and diastolic motion were reduced both with age and in DM patients. Systolic LV torsion was increased with age and in DM, with no corresponding increase in torsional relaxation. Both systolic and diastolic function parameters were regionally heterogeneous. With normal ageing, diastolic function was impaired in a regionally non-uniform manner. Thus, a complete assessment of LV function requires measurement of LV tissue mechanics as well as chamber haemodynamics. MRI provides valuable information regarding myocardial tissue behaviour, contributing to systolic and/or diastolic dysfunction, which cannot be obtained otherwise. Systolic tissue dysfunction may develop concomitantly in patients with diastolic dysfunction, even when global ejection fraction is preserved. Regional analyses provide important information on how local changes contribute to global function. The influence of age must be taken into account in studies of disease.
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Books on the topic "Diastolic function of the left ventricle"

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Dries, David J. Right ventricle: The neglected neighbor of the left. R.G. Landes, 1994.

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Kantor, B. I͡A. Noninvasive diagnostics of the left heart: Biomechanical disturbances. Nova Science Publishers, 1995.

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Smiseth, Otto A., Maurizio Galderisi, and Jae K. Oh. Left ventricle: diastolic function. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198726012.003.0021.

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Evaluation of diastolic function by echocardiography is useful to diagnose heart failure with preserved ejection fraction by showing signs of diastolic dysfunction, and regardless of ejection fraction, echocardiography can be used to estimate left ventricular (LV) filling pressure. Diastolic dysfunction occurs in a number of cardiac diseases other than heart failure and mild diastolic dysfunction is part of the normal ageing process. The fundamental disturbances in diastolic dysfunction are slowing of myocardial relaxation, loss of restoring forces, and reduced LV chamber compliance. As a compensatory response there is elevated LV filling pressure. Slowing of relaxation and loss of restoring forces are reflected in reduction in LV early diastolic lengthening velocity (e?) by tissue Doppler. The reduced diastolic compliance is reflected in faster deceleration of early diastolic transmitral velocity by pulsed wave Doppler. Elevated LV filling pressure is reflected in a number of Doppler indices and in enlarged left atrium. This chapter reviews the physiology of diastolic function, the clinical methods and indices which are available, and how these should be applied.
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D’Andrea, Antonello, André La Gerche, and Christine Selton-Suty. Systemic disease and other conditions: athlete’s heart. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198726012.003.0055.

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The term ‘athlete’s heart’ refers to the structural, functional, and electrical adaptations that occur as a result of habitual exercise training. It is characterized by an increase of the internal chamber dimensions and wall thickness of both atria and ventricles. The athlete’s right ventricle also undergoes structural, functional, and electrical remodelling as a result of intense exercise training. Some research suggests that the haemodynamic stress of intense exercise is greater for the right heart and, as a result, right heart remodelling is slightly more profound when compared with the left heart. Echocardiography is the primary tool for the assessment of morphological and functional features of athlete’s heart and facilitates differentiation between physiological and pathological LV hypertrophy. Doppler myocardial and strain imaging can give additional information to the standard indices of global systolic and diastolic function and in selected cases cardiac magnetic resonance imaging may help in the diagnosis of specific myocardial diseases among athletes such as hypertrophic cardiomyopathy, dilated cardiomyopathy, or arrhythmogenic right ventricular cardiomyopathy.
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Cosyns, Bernard, Thor Edvardsen, Krasimira Hristova, and Hyung-Kwan Kim. Left ventricle: systolic function. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198726012.003.0020.

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The assessment of left ventricular (LV) systolic function is one of the most important parts of correct diagnosis, selection of treatment strategy or medications, and prediction of prognosis. Although cardiac magnetic resonance imaging is generally accepted as the gold standard in vivo imaging modality for assessing LV systolic function, its practical use is limited due to its limited availability, high cost, and the presence of conditions precluding its performance such as a pacemaker, claustrophobia, and severe arrhythmia. Thus, transthoracic echocardiography is a first-line imaging modality employed in daily practice and has been widely used. Since the first attempts with M-mode approach, remarkable improvements have been made with the advent of two-dimensional echocardiography, and more recently three-dimensional echocardiography, with high accuracy and reproducibility. More sophisticated methodologies such as strain imaging, based on Doppler or speckle tracking techniques, provide a more sensitive and quantitative measurement of myocardial contractility, and are gaining a place in common daily practice. This chapter describes different modalities that have been used for assessment of LV systolic function based on echocardiography, and is grossly composed of two parts: LV global systolic function and LV regional or segmental systolic function. For better application of these conventional and novel methods of assessing LV systolic function, strengths and pitfalls of these techniques should be acknowledged.
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Rigo, Fausto, Covadonga Fernández-Golfín, and Bruno Pinamonti. Dilated cardiomyopathy. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198726012.003.0043.

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Dilated cardiomyopathy (DCM) is characterized by a globally dilated and dysfunctioning left ventricle (LV). Therefore, echocardiographic diagnostic criteria for DCM are a LV end-diastolic diameter greater than 117% predicted value corrected for age and body surface area and a LV ejection fraction less than 45% (and/or fractional shortening less than 25%). Usually, the LV is also characterized by a normal or mildly increased wall thickness with eccentric hypertrophy and increased mass, a spherical geometry (the so-called LV remodelling), a dyssynchronous contraction (typically with left bundle branch block), and diastolic dysfunction with elevated LV filling pressure. Other typical echocardiographic features of DCM include functional mitral and tricuspid regurgitation, right ventricular dysfunction, atrial dilatation, and secondary pulmonary hypertension. Several echocardiographic parameters, measured both at baseline and at follow-up, are valuable for prognostic stratification of DCM patients. Furthermore, re-evaluation of echocardiographic parameters during the disease course under optimal medical therapy is valuable for tailoring medical treatment and confirming indications for invasive treatments at follow-up. The stress echo can play a pivotal role in the different phases of DCM helping us in stratifying the prognosis of these patients. Finally, familial screening is an important tool for early diagnosis of DCM in asymptomatic patients.
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Lancellotti, Patrizio, and Bernard Cosyns. Assessment of Diastolic Function. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198713623.003.0005.

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Diastole is the part of the cardiac cycle starting at aortic valve closure and ending at mitral valve closure. Evaluation of diastolic function by echocardiography is useful to diagnose heart failure with preserved ejection fraction, and regardless of ejection fraction, echocardiography can be used to estimate left ventricular filling pressure. Assessment of diastolic function includes analysis of left ventricular relaxation and compliance, left atrial and left ventricular filling pressures. This chapter describes the phases of diastole and covers the integrated approach of LV diastolic function through M-Mode and 2D/3D echocardiography, pulsed-wave Doppler echocardiography, and pulsed-wave tissue Doppler echocardiography.
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Galderisi, Maurizio, and Sergio Mondillo. Assessment of diastolic function. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199599639.003.0009.

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Modern assessment of left ventricular (LV) diastolic function should be based on the estimation of degree of LV filling pressure (LVFP), which is the true determinant of symptoms/signs and prognosis in heart failure.In order to achieve this goal, standard Doppler assessment of mitral inflow pattern (E/A ratio, deceleration time, isovolumic relaxation time) should be combined with additional manoeuvres and/or ultrasound tools such as: ◆ Valsalva manoeuvre applied to mitral inflow pattern. ◆ Pulmonary venous flow pattern. ◆ Velocity flow propagation by colour M-mode. ◆ Pulsed wave tissue Doppler of mitral annuls (average of septal and lateral E′ velocity).In intermediate doubtful situations, the two-dimensional determination of left atrial (LA) volume can be diagnostic, since LA enlargement is associated with a chronic increase of LVFP in the absence of mitral valve disease and atrial fibrillation.Some new echocardiographic technologies, such as the speckle tracking-derived LV longitudinal strain and LV torsion, LA strain, and even the three-dimensional determination of LA volumes can be potentially useful to add further information. In particular, the reduction of LV longitudinal strain in patients with LV diastolic dysfunction and normal ejection fraction demonstrates that a subclinical impairment of LV systolic function already exists under these circumstances.
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Zhang, Peng-Fei, Yun Zhang, and Siew Yen Ho. Left ventricle: morphology and geometry. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198726012.003.0018.

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The left ventricle is a cone-shaped muscular pump which receives the blood from the left atrium through the inflow tract and ejects it to the aorta through the outflow tract. The double helical myocardial fibre formation is the basis of efficient motion, function, and morphology of the left ventricle. Physiological or pathological changes of these characteristics of the left ventricle can be evaluated by echocardiography. This chapter describes the morphology and geometry of the left ventricle, including the inflow tract, the outflow tract, double helix formation of left ventricle myocardium, and the echocardiographic assessment of left ventricle morphology and geometry.
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The effect of oral smokeless tobacco on left ventricular function. 1987.

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Book chapters on the topic "Diastolic function of the left ventricle"

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Toader, Despina-Manuela. "Left Ventricle Diastolic Function Evaluation in Patients with Implanted Devices." In Echocardiographic Evaluation of Patients with Implanted Devices. Springer Nature Switzerland, 2024. http://dx.doi.org/10.1007/978-3-031-64079-7_3.

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Garcia, Kristen, Marcus Hock, Vikrant Jaltare, et al. "Investigating the Multiscale Impact of Deoxyadenosine Triphosphate (dATP) on Pulmonary Arterial Hypertension (PAH) Induced Heart Failure." In Computational Physiology. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-05164-7_7.

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Abstract2-deoxy-ATP (dATP) is a myosin activator known to improve cardiac contractile force [1]. In vitro studies have shown that dATP alters the calcium transient profile in addition to the kinetics of the cross-bridge cycle [2]. Furthermore, in vivo studies of transgenic mice with increased production of dATP show elevated left ventricular systolic function [3]. Pulmonary arterial hypertension (PAH) is a rare disease of the pulmonary vasculature in which pressure overload in the right ventricle results in reduced contractile function and right heart failure [4]. We hypothesize that dATP may have a therapeutic effect on PAH-induced heart failure, by improving contractile function and restoring cardiac output and ejection fraction. However, because the effects of dATP cannot easily be assessed experimentally, we propose using a computational multiscale modeling approach to predict cardiac function. By altering parameters in an existing multiscale biventricular cardiac model [5], we were able to reproduce end-systolic and end-diastolic pressures and volumes that reflect the PAH condition, as well as healthy hearts. dATP was simulated by adjusting parameters in the model at the molecular and cellular levels based on experimental data [1], allowing us to predict the effects of dATP on PAH at the organ level. Our results show that the molecular effects of dATP can increase cardiac output and restore ejection fraction in PAH conditions, though at the cost of elevated mean arterial pressure, and may provide a new approach to treating this disease. Our multiscale modeling approach paves the way for further studies mapping out cardiovascular mechanics. As novel therapeutics continue to be discovered, their application and mechanism can be further explored through these computational models.
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Gaasch, William H., Carl S. Apstein, and Herbert J. Levine. "Diastolic Properties of the Left Ventricle." In The Ventricle. Springer US, 1985. http://dx.doi.org/10.1007/978-1-4613-2599-4_7.

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De Hert, Stefan G. "Left Ventricular Diastolic Function." In Transoesophageal Echocardiography in Anaesthesia and Intensive Care Medicine. BMJ Publishing Group, 2008. http://dx.doi.org/10.1002/9780470760239.ch4.

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Rambhatla, Tarak, and Gila Perk. "Left Ventricular Diastolic Function." In The Echocardiography Companion. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-47041-8_5.

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Fox, Steven, Milad Matta, and Siddharth Dugar. "Left Ventricle Systolic Function." In Critical Care Echocardiography. Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-45731-9_5.

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Grossman, William. "Relaxation and Diastolic Distensibility of the Regionally Ischemic Left Ventricle." In Diastolic Relaxation of the Heart. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4615-6832-2_20.

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Fouad-Tarazi, Fetnat M. "Left ventricular diastolic function in hypertension." In The Heart in Hypertension. Springer Netherlands, 1989. http://dx.doi.org/10.1007/978-94-009-0941-0_19.

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Krayenbuehl, H. P., M. Jakob, and O. M. Hess. "Left Ventricular Function: Systolic and Diastolic Alterations." In Coronary Artery Graft Disease. Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-78637-2_11.

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Jehle, J., H. Rose, F. K. Schmiel, P. Spiller, and L. J. Ulbricht. "Angiographic Analysis of Left Ventricular Diastolic Function." In Angiocardiography. Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-662-00820-1_16.

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Conference papers on the topic "Diastolic function of the left ventricle"

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Shandas, Robin, Jean R. Hertzberg, Jason E. Cooke, and Matthieu Boardman. "Left Ventricular Filling Dynamics: Particle Image Velocimetry and Ultrasound Color M-Mode Imaging." In ASME 2001 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2001. http://dx.doi.org/10.1115/imece2001/bed-23114.

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Abstract Studies have shown that left ventricular diastolic function is an important indicator of overall cardiac health [1,2]. Quantitation of diastolic function using non-invasive imaging techniques continues to be a long-standing goal for clinicians. The recent development of ultrasound Doppler color M-mode imaging techniques to measure the speed of flow propagation within the ventricle during diastole appears promising in this regard. However, significant subjectivity in measuring flow propagation speed exists. One reason for this is that the relationship between clinically derived parameters such as color M-mode flow propagation and underlying fluid mechanics of diastolic filling is still unclear.
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Ibrahim, Nabilah, Muhammad Haniff S. M. Johan, Lina Farhana Mahadi, and Wan Mahani Hafizah Wan Mahmud. "Assessment on blood flow velocity at left ventricle for diastolic function diagnosis." In 2017 6th International Conference on Electrical Engineering and Informatics (ICEEI). IEEE, 2017. http://dx.doi.org/10.1109/iceei.2017.8312432.

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Peterson, Sherket B., Branislav Radovancevic, Antonietta Hernandez, et al. "Diastolic Dysfunction Persists After Unloading by Left Ventricular Assist Device (LVAD) Support." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176158.

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Left Atrium (LA) size has prognostic importance in a variety of cardiac conditions [1] and is known to be enlarged with decreased contractile function in patients with congestive heart failure (CHF) [2]. Nearly 5 million Americans have CHF [3] and a majority of these patients display diastolic dysfunction, which is an abnormality in the left ventricle (LV) myocardial relaxation and/or compliance that alters the ease with which the blood is accepted into the LV from the LA during diastole [4]. Due to abnormal LV filling, the LA experiences intense stress and elevated pressures. In fact, the left atrium is exposed directly to the LV diastolic pressure through the open mitral valve (MV) and because of its thin wall structure it tends to dilate with increasing pressure [5]. This augmented LA size and increased contractility and booster function are some of the mechanisms compensating for decreased early filling in patients with reduced LV compliance [6]. Over time, the LA compensatory contribution decreases, this may lead to intrinsic left atrium dysfunction [7]. This in turn results in a progressive decline in health unless the hearts’ inadequate blood flow is augmented by a left ventricular assist device (LVAD). Although LVAD implantation rest the heart, restores function to the ventricle [8], and improve overall function [9], its effects on the left atrium remain unclear. The purpose of the present study was to use 2D and Doppler echocardiography to define the parameters for assessing LVAD unloading and determine its effect on LA diameter, area, volume, and pressure in patients prior to and following LVAD implantation.
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Seidel, Joshua B., J. Michael Kabo, and Vidya K. Nandikolla. "Modeling and Analysis of Heart Left Ventricle in Diastole Using Finite Element." In ASME 2016 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/imece2016-65338.

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Finite element is used to analyze the effects of infarct on left ventricular end-diastolic function. The results for the symmetric infarct cases 1–6 demonstrated in this paper correspond to infarct percent by volume of 4, 8, 9, 16, 25 and 51% respectively. Using the developed three-dimensional model, these infarct percent by volume showed a reduction in end-diastolic volume (EDV) of 3, 5, 5, 8, 11, 17 mL respectively. Three natural infarct cases denoted A, B and C was evaluated consisting of 7%, 15% and 50% infarct region by volume respectively. The decrease in EDV for cases A, B and C were 6, 9 and 17 mL. The simulated decrease in EDV for the infarct cases was consistent with patients experiencing decreased tissue compliance. The higher left ventricle (LV) pressure resulted in an increase in wall stress opposite to the infarct for the symmetric and natural infarct cases.
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Van Der Smissen, Benjamin, Tom E. Claessens, Ernst R. Rietzschel, et al. "Noninvasive Assessment of Diastolic Intraventricular Pressure Gradients in a Large General Population (the Asklepios Study)." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19328.

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Accurate assessment of diastolic (dys)function by non-invasive techniques has important therapeutic and prognostic implications but remains a challenge to the cardiologist. A promising parameter to evaluate diastolic (dys)function more accurately is the early diastolic intraventricular pressure gradient (IVPGe) which is considered representative of the active relaxation of the left ventricle. It has been shown that IVPGe can be estimated non-invasively by measuring blood velocities along a base-to-apex scan line using color M-mode Doppler (CMD) echography [1]. Although this technique is known for about 20 years, IVPGe is still not used in daily clinical practice because its approach is complicated and too laborious [2].
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Korotenko, O. Yu, E. S. Filimonov, and N. I. Panev. "COMPARATIVE ECHOCARDIOGRAPHIC STUDY OF TRAINED WORKERS OF THE MAIN PROFESSIONS OF THE COAL AND ALUMINUM INDUSTRY." In The 17th «OCCUPATION and HEALTH» Russian National Congress with International Participation (OHRNC-2023). FSBSI «IRIOH», 2023. http://dx.doi.org/10.31089/978-5-6042929-1-4-2023-1-225-228.

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The coal mining and metallurgical industries are characterized by the presence of harmful production factors, the negative effects of which, in concentrations exceeding the maximum permissible levels, can lead to myocardial remodeling and impaired heart function. The objective of the study — conduct a comparative echocardiographic study in trained workers in the main professions of the coal and aluminum industries. Material and methods. The study included 62 miners and 42 workers of the main professions of aluminum production with more than 20 years of work experience in hazardous working conditions, aged 40‑55 years (p=0.190). The subjects did not have any somatic pathology that could lead to structural and functional changes in the heart. All underwent echocardiography according to the standard technique with automatic calculation of the global longitudinal deformation of the left ventricle. Results. There were no differences between the geometric parameters of the left parts of the heart between the groups. Lower values of the ejection fraction of the left ventricle and its longitudinal deformation were found in aluminum industry workers (p=0.037 and p=0.0062). The average speed of the mitral ring also turned out to be significantly lower in metallurgists (p=0.00007). A decrease in longitudinal deformation of the left ventricle was found in 14.5% of miners and 26.8% of metallurgists, p=0.122. There were no significant differences in the parameters of diastolic function of the left ventricle. Conclusion. Indicators of contractile function of the left ventricle in workers of the aluminum industry were significantly lower compared to those in miners, which indicates the need for preclinical diagnosis of left ventricular systolic dysfunction, dynamic monitoring and timely prevention.
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Nikonovа, V. V., and T. O. Holovko. "Heart remodeling and state of diastolic function of the left ventricle in adolescents with myocardial pathology." In DEVELOPMENT OF THE HEALTHCARE SECTOR IN UKRAINE: THE PATH TOWARDS THE EUROPEAN UNION. Baltija Publishing, 2023. http://dx.doi.org/10.30525/978-9934-26-387-3-6.

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Masithulela, Fulufhelo. "The Effect of Over-Loaded Right Ventricle During Passive Filling in Rat Heart: A Biventricular Finite Element Model." In ASME 2015 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/imece2015-50004.

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The physiological basis of the right ventricle diastolic function is not well studied. In most heart failure, heart transplantation remains the first choice with survival ranges between 40% and 50%. It is known that heart transplantation lacks donors and therefore, there is a need to search for new surgical techniques for heart failure prevention. This study utilized the finite elment method to study the structural behavior of heart wall under severe pressures. In this study the effect RV filling during over-pressurised RV using bi-ventricular model has been studied using finite element modeling (FEM). Cardiovascular disease (CVD) is the leading cause of death in low-income and middle-income countries. The right ventricle (RV) dysfunction is understood to have an impact on the performance of the left ventricle (LV) but the mechanisms remain poorly understood. Finite strain analyses of bi-ventricular model provide important information on the heart function. The passive myocardium was modelled as a nearly incompressible, hyperelastic, transversely isotropic material. Biventricular geometries of healthy and infarcted rat hearts reconstructed from magnetic resonance images were imported in Abaqus©. In simulating the passive filling of the healthy condition of the rat heart, the inner walls of the LV and RV the pressures of 4.8 kPa and 0.0098 kPa were applied respectively. The average circumferential strain was found to be 0.138 and 0.100 on the endocardium of the over-pressured and healthy model respectively. The high stresses and strains on the over-loaded model were observed.
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Hu, Yingying, Liang Shi, Siva Parameswaran, Sergey A. Smirnov, and Zhaoming He. "Numerical Study on Diastolic Left Ventricular Hemodynamics Using Motion Models of Mitral Valve With/Without Edge-to-Edge Repair." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19570.

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Edge-to-edge repair (ETER) is a newly developed technique to correct such mitral valve (MV) malfunctions as regurgitation [1,2]. This technique changes MV geometric configuration by suturing the anterior and posterior leaflets at central or commissural edges, and consequently alters MV and left ventricle (LV) dynamics. For instance, stress in the MV elevated due to ETER may cause leaflets tearing near suture. Little has been known about shear stress on the MV and LV walls under MV ETER conditions, where high shear stress might cause platelet activation or hemolysis [3]. When ETER is done at the central leaflet edges, it generates two MV orifices, leads to two deflected jets, and completely changes vortices in the LV. ETER also reduces the orifice area, and increases jet velocity and transmitral pressure [1,2,4]. Flow patterns in the LV and ETER effects on the LV and MV functions have not been understood well.
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Andreeva, Yulia A., Marina A. Saidova, Tamila V. Martynyuk, et al. "Diastolic Function Of Left And Right Ventricles By Echocardiography And Tissue Doppler Imaging In Various Forms Of Pulmonary Hypertension." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a3407.

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Reports on the topic "Diastolic function of the left ventricle"

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Liu, Gejing, Man Ren, Yingshi Du, et al. A meta-analysis of Effect of thyroid hormone replacement therapy on the Cardiac diastolic function in Patients with Subclinical Hypothyroidism. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2023. http://dx.doi.org/10.37766/inplasy2023.2.0083.

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Review question / Objective: P:Subclinical Hypothyroidism(Age over 18); I:thyroid hormone replacement therapy; C:baseline(before-after study in the same patient); O:Cardiac diastolic function measurement by echocardiography. Condition being studied: Subclinical hypothyroidism is associated with anomalies left ventricular diastolic functions, however, there are still disputes about whether to use levothyroxine for treatment. This meta-analysis aimed to determine whether levothyroxine (LT4), commonly used to treat hypothyroidism, affects cardiovascular indices in SCH patients as measured by echocardiography.
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