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V Baroncini, Liz Andréa. "Right ventricle Outflow Tract Acceleration Time: Correlation with Left Ventricular Diastolic Function." Clinical Imaging and Interventional Radiology 3, no. 1 (2020): 01–05. http://dx.doi.org/10.31579/2642-1674/008.
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Background: There are no available data about the measurement of acceleration time at the right ventricle outflow tract (AcT) and its relevance in the analysis of the left ventricular diastolic function (LVDF). Objective: To correlate AcT with echocardiographic parameters of LVDF. Method: Eighty-seven patients (58.4±14.5 years; 52% women) submitted to transthoracic echocardiogram assessing spectral and tissue Doppler of the transmitral flow and mitral annulus, AcT, left atrial volume (LAV), and pulmonary artery systolic pressure (PASP). Patients with systolic dysfunction of the LV and grades II and III diastolic dysfunction (DD) were excluded. Main analyses were performed using the Spearman’s Correlation Coefficient (SCC) and Pearson’s Linear Correlation Coefficient (PLCC). Results: A negative correlation between AcT value and age (PLCC – 0.36; Student’s t-test; p <0.001) and a positive correlation between AcT and E/A ratio (SCC 0.38; p<0.001), between AcT and E/e’ ratio (SCC 0.26; p=0.01), between AcT and E wave of the mitral flow (PLCC 0.36; p= 0.001) were found. LAV and PASP did not correlate with AcT. In patients with a normal diastolic function, AcT was higher when compared with the AcT in patients with Grade I DD (0.150±0.029ms versus 0.127±0.023ms; p<0.001; Student’s t-test). The threshold suggested in this subgroup of patients was 0.135s. Conclusions: The present study correlated, unprecedentedly, AcT with echocardiographic parameters of the LV diastolic function. AcT values lower than 0.135s were associated with grade I diastolic dysfunction and higher than 0.135s values were associated with normal diastole.
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Spaska, G. "Heart left ventricle’s diastolic function features in patients with reactive arthritis." Likarska sprava, no. 3 (May 29, 2013): 56–58. http://dx.doi.org/10.31640/ls-2013-3-09.
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Cross-correlation analysis’s data indicate for the patients with reactive arthritis features, which determine character the left ventricle’s diastolic filling, are end-diastolic pressure and end-diastolic pressure / end-diastolic volume index in the left ventricle.
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WRANNE, B., and G. SUTHERLAND. "DIASTOLIC FUNCTION OF THE LEFT VENTRICLE." Echocardiography 15, no. 8-2 (1998): S74—S75. http://dx.doi.org/10.1111/j.1540-8175.1998.tb00976.x.
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Kuznetsova, V. V., and A. V. Bursikov. "Diastolic function left ventricle in a debut of revealing of hypertonic illness at young age." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 13, no. 4 (2007): 292–94. http://dx.doi.org/10.18705/1607-419x-2007-13-4-292-294.
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The purpose: To estimate diastolic function left ventricle at persons of young age with recently revealed arterial hypertension and to reveal early attributes of its infringement. Materials and methods: On device LOGIQ 500 method Doppler echocardiography studies diastolic function left ventricle at 34 patients of young age with prescription of revealing arterial hypertension no more than 3 years and practically healthy 48 persons. Results: At an arterial hypertension already in a debut of revealing of disease change of some Doppler echocardiography parameters diastolic fillings left ventricle takes place: decrease in high-speed parameters early diastolic fillings and increase in peak speed and fraction of late filling left ventricle, that reflects difficulty of filling left ventricle and increased hemodinamic loading on the left auricle. The conclusion: Changes of speeds diastolic fillings left ventricle reflects its structurally functional remodeling and can be used as criterion of diagnostics of defeat of heart at arterial hypertension
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Solomon, Steven B., Srdjan D. Nikolic, Stanton A. Glantz, and Edward L. Yellin. "Left ventricular diastolic function of remodeled myocardium in dogs with pacing-induced heart failure." American Journal of Physiology-Heart and Circulatory Physiology 274, no. 3 (1998): H945—H954. http://dx.doi.org/10.1152/ajpheart.1998.274.3.h945.
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In patients with heart failure, decreased contractility resulting in high end-diastolic pressures and a restrictive pattern of left ventricular filling produces a decrease in early diastolic filling, suggesting a stiff ventricle. This study investigated the elastic properties of the myocardium and left ventricular chamber and the ability of the heart to utilize elastic recoil to facilitate filling during pacing-induced heart failure in the anesthetized dog. Elastic properties of the myocardium were determined by analyzing the myocardial stress-strain relation. Left ventricular chamber properties were determined by analyzing the pressure-volume relation using a logarithmic approach. Elastic recoil was characterized using a computer-controlled mitral valve occluder to prevent transmitral flow during diastole. We conclude that, during heart failure, the high end-diastolic pressures suggestive of a stiff ventricle are due not to stiffer myocardium but to a ventricle whose chamber compliance characteristics are changed due to geometric remodeling of the myocardium. The restrictive filling pattern is a result of the ventricle being forced to operate on the stiff portion of the diastolic pressure-volume relation to maintain cardiac output. Slowed relaxation and decreased contractility result in an inability of the heart to contract to an end-systolic volume below its diastolic equilibrium volume. Thus the left ventricle cannot utilize elastic recoil to facilitate filling during heart failure.
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Koshlya, V. I., O. S. Kulbachuk, N. P. Sklyarova, A. V. Piskun, and O. V. Solovyov. "Changes of the diastolic function of left ventry in patients with arterial hypertension in the process of micardis treatment in the family doctor's conditions." Modern medical technologies 40, no. 1 (2019): 45–47. http://dx.doi.org/10.34287/mmt.1(40).2019.7.
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Among 38 patients with arterial hypertension I and II degree, the diastolic function of the left ventricle was studied in the course of a twelve-month treatment with Telmisartan (Micardis). Analysis of the diastolic function of the left ventricle before the treatment with telmisartan showed that in both groups of patients with respect to the control group there was a significant decrease in the maximum speed of early diastolic filling and an increase in the maximum rate of atrial filling with increasing severity of the disease.At the same time, the period of isovolumetric relaxation and the end diastolic pressure in the left ventricle increased, and the E/A and Ei/Ai ratios tended to decrease. At the end of the 12-month period of treatment with micardis, the achievement of target levels of blood pressure and normalization of diastolic function of the left ventricle were noted. Keywords: arterial hypertension, left ventricular diastolic dysfunction, micardis.
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Shveс, D. A., and S. V. Povetkin. "The Role of Residual Stenosis of the Coronary Arteries in the Dynamics Systolicdiastolic Left Ventricular Function after Acute Coronary Syndrome." Kardiologiia 60, no. 2 (2020): 33–40. http://dx.doi.org/10.18087/cardio.2020.2.n853.
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Objective. The aim of the research under consideration was to study the dynamics of a local systolic-diastolic function of patients with various ischemic heart disease (IHD) progressions after survival of an acute coronary syndrome (ACS) provided there are residual stenoses of coronary arteries.Materials and Methods. There were 112 patients suffering from ACS who took part in the research. The diagnosis was verified (acute myocardial infarction or unstable angina) in accordance with the recommendations of European Society of Cardiology (ESC). All patients were divided into two groups depending on the occurrence of major acute cardiac events (MACE): 59 patients with aggravated IHD progression and 152 patients with non-aggravated course. Echo-cardiography was performed on a scanner Philips iE33 (the Netherlands) with a consideration to systolic and diastolic functions parameters of a left ventricle. Quantitative analysis of the left ventricle was executed in the mode of Tissue Doppler Imaging (TDI) and according to the method of tracing the patches of the ultra-sound image gray scale (ST).Results. In the course of the aggravated IHD a decrease in systolic-diastolic function of left ventricle has been discovered. It has been found out that the amount of the systolic peak of longitudinal strain of the left ventricle anteroseptal wall less than 12% is associated with a greater extent of coronary atherosclerosis and aggravated progression of IHD. TDI and ST methods have enabled to reveal that in the course of non-aggravated IHD the contractility and the diastolic function of the left ventricle anteroseptal wall improve in combination with the increase in the contractility of the left ventricle inferolateral wall. During an aggravated IHD progression the contractility and diastolic function of the left ventricle anteresoptal wall decreases without an increase in contractility and diastolic function of the inferior and inferolateral walls of the left ventricle. The reason for such results might be a progressing myocardial ischemia of the left ventricle anteroseptal wall despite the sufficient anterior interventricular artery stenting. The presence of the relevant residual stenoses of the circumflex and right coronary arteries increases the possibility of the aggravated IHD progressing especially by the end of the fourth year of observation.Conclusion. The disbalance of the local contractility of anterior, inferior and inferolateral left ventricle walls in the course of aggravated IHD is connected with the CA residual stenoses presence and forwards the decrease in global systolic-diastolic function of the left ventricle. The final results can serve as a foundation for optimization of recommendations for performing PCI on the patients with multivessel disease of CA.
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Deljanin-Ilic, Marina, Stevan Ilic, Dragan Djordjevic, Marija Zdravkovic, and Vladimir Ilic. "Evaluation of myocardial function in the presence of left ventricular hypertrophy in athletes and hypertensive patients." Medical review 61, no. 3-4 (2008): 178–82. http://dx.doi.org/10.2298/mpns0804178d.
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Introduction Myocardial hypertrophy of the left ventricle may be of physiological or pathological nature. Distinction of these two types of hypertrophy is sometimes not easy and represents a diagnostic challenge. The aim of the study was to assess global diastolic and regional systolic and diastolic myocardial function in the presence of left ventricular hypertrophy in athletes and hypertensive patients. Material and methods In 18 male hypertensive patients and 14 male athletes global diastolic left ventriclar function and regional systolic and diastolic myocardial function of septum and posterior wall were investigated by pulsed wave tissue Doppler imaging. Results Ejection fraction and left ventricle mass index did not differ significantly between two groups. Hypertensive patients were found to have diastolic dysfunction while athletes had normal left ventricular diastolic function (the difference between the groups was P<0.00001). Index of regional diastolic function of septum as well as of the posterior wall was significantly less in hypertensive patients than in athletes (P<0.00001 for both). In spite of the normal global systolic function the regional systolic function of septum and posterior wall was significantly less in hypertensive patients than in athletes (P<0.02for both). Conclusion The present results show significantly less global and regional diastolic function of hypertrophied myocardium in hypertensive patients than in athletes. In the presence of preserved left ventricular systolic function, the quantification of myocardial velocity revealed significantly lower regional systolic function of septum and posterior wall in hypertensive patients than in athletes.
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Yao, Shifa, Tian Yang, Xiaoxiao Kong, Yuanyuan Dang, Ping Chen, and Mingli Lyu. "The Influence of Maternal Condition on Fetal Cardiac Function during the Second Trimester." Diagnostics 13, no. 17 (2023): 2755. http://dx.doi.org/10.3390/diagnostics13172755.
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Objective: Maternal health has a direct, profound and lasting effect on the formation and development of the fetal cardiovascular system. The aim of this research was to find whether maternal age, BMI hypertension (GH) or gestational diabetic mellitus (GDM) would affect fetal cardiac function in the second trimester. Method: 329 mothers who had a fetal echocardiogram examination at the International Peace Maternity & Child Health Hospital of China Welfare Institute, Shanghai, China, from 1 January 2020 to 30 April 2020 were enrolled at the gestational age of 21 to 26 weeks (mean 22.78 ± 1.13 weeks). Single-factor analysis and multi-factor line regression analysis were used to find the contribution values of each factor to fetal cardiac function. Results: at the second trimester, maternal age had a minor influence on the fetal left ventricle diastolic function. Higher maternal BMI could cause a decrease in the fetal diastolic function of both the left and right ventricle and the systolic function of the left ventricle. Maternal hypertension and gestational diabetic mellitus had a profound influence on both the left and right fetal heart ventricles of both systolic and diastolic function. Conclusion: maternal condition will have a profound influence on fetal cardiac function as early as the second trimester.
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Vysotskaya, N. V., V. V. Lee, N. Yu Timofeeva, V. S. Zadionchenko, and T. V. Adasheva. "THE ASSOCIATION BETWEEN INTRACARDIAC HEMODYNAMICS AND LUNG FUNCTION IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE." Russian Archives of Internal Medicine 9, no. 5 (2019): 373–81. http://dx.doi.org/10.20514/2226-6704-2019-9-5-373-381.
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Study objective. To assess the association between intracardiac hemodynamics and airway obstruction with pulmonary hyperinflation in patients with chronic obstructive pulmonary disease.Materials and methods. Ninety-six patients with chronic obstructive pulmonary disease, aged 40 to 75 years, without concomitant cardiovascular disease, were examined and divided into 4 groups according to the severity of the disease. The patients underwent general clinical examination, spirometry, 24-hour pulse oximetry and echocardiography with assessment of linear and volumetric parameters, as well as diastolic function of left and right ventricles.Results. Linear and volumetric parameters of the left ventricle, LV myocardial mass and geometry in the examined patients with chronic obstructive pulmonary disease matched threshold values. The progression of the severity of chronic obstructive pulmonary disease was accompanied by decrease of the end-diastolic size of the left ventricle, ratio of peak early to late diastolic filling velocity for the left ventricle (E/A) without significant changes in the left ventricle isovolumetric relaxation time (IVRT). Moderate correlations of the inspiratory capacity with the end-diastolic size of the left ventricle (r=0.612; p=0.001) and the left ventricle E/A (r=0.464; p=0.001); forced expiratory volume in 1 second (FEV1) with the left ventricle E/A (r=0.600; p=0.011) were established. As a result of the logistic regression performed, the predictor value of the inspiratory capacity was confirmed (Wald χ2 — 5.795; р=0.024). Impairment of left ventricular diastolic function of grade I was revealed in 12 (31.6 %) patients in group 2, in 7 (24.1 %) patients in group 3, and in 9 (56.2 %) patients in group 4.Conclusion. Airway obstruction severity and pulmonary hyperinflation progression in patients with chronic obstructive pulmonary disease and without concomitant cardiovascular disease is associated with a decrease of left ventricular size and diastolic filling, contributes to the development of the left ventricular diastolic dysfunction, predominantly due to the decrease in filling velocity parameters.
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Wang, Han, Hanxiong Liu, Xiuqiong Yu, Hui Jiang, Yinli Wang, and Lin Cai. "Left ventricle diastolic function in patients with polymyositis." International Journal of Cardiology 168, no. 4 (2013): 4311–12. http://dx.doi.org/10.1016/j.ijcard.2013.04.185.
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Paulus, Walter J., Pascal J. Vantrimpont, and Michel F. Rousseau. "Diastolic function of the nonfilling human left ventricle." Journal of the American College of Cardiology 20, no. 7 (1992): 1524–32. http://dx.doi.org/10.1016/0735-1097(92)90446-t.
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Skorodumova, E. G., V. A. Kostenko, E. A. Skorodumova, I. N. Gayvoronskiy, A. V. Siverina, and A. V. Rysev. "Systolic-diastolic attitude in patients with acute decompensation of heart failure." EMERGENCY MEDICAL CARE 22, no. 3 (2021): 19–23. http://dx.doi.org/10.24884/2072-6716-2021-22-3-19-23.
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The aim of the study was to evaluate the systolic-diastolic ratio in patients with acute decompensation of heart failure against the background of the intermediate function of the left ventricle. This article is based on data from 585 electrocardiograms of 195 patients (98 males and 97 females), the average age was 64.6±14.8 years. By the level of the ejection fraction of left ventricle (LVEF), all patients were divided into three groups: with a reduced LVEF an intermediate LVEF and a preserved LVEF. As a result it was shown that in the groups of intermediate and low EF, when the systole of ventricles dominate over the diastole, but under the treatment ratio changed to the prevalence of diastole. In the preserved LVEF sample diastole dominates at all stages of the observation. Analysis of the ratio described may be useful for assessment of treatment effectiveness and coronary flow in patients with different types of LV function under acute heart failure decompensation.
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Villars, Penelope S., Shannan K. Hamlin, Andrew D. Shaw, and Joseph T. Kanusky. "Role of Diastole in Left Ventricular Function, I: Biochemical and Biomechanical Events." American Journal of Critical Care 13, no. 5 (2004): 394–403. http://dx.doi.org/10.4037/ajcc2004.13.5.394.
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Left ventricular diastolic function plays an important role in cardiac physiology. Lusitropy, the ability of the cardiac myocytes to relax, is affected by both biochemical events within the myocyte and biomechanical events in the left ventricle. β-Adrenergic stimulation alters diastole by enhancing the phosphorylation of phospholamban, a substrate within the myocyte that increases the uptake of calcium ions into the sarcoplasmic reticulum, increasing the rate of relaxation. Troponin I, a regulatory protein involved in the coupling of excitation to contraction, is vital to maintaining the diastolic state; depletion of troponin I can produce diastolic dysfunction. Other biochemical events, such as defects in the voltage-sensitive release mechanism or in inositol triphosphate calcium release channels, have also been implicated in altering diastolic tone. Extracellular collagen determines myocardial stiffness; impaired glucose tolerance can induce an increase in collagen cross-linking and lead to higher end-diastolic pressures. The passive properties of the left ventricle are most accurately measured during the diastasis and atrial contraction phases of diastole. These phases of the cardiac cycle are the least affected by volume status, afterload, inherent viscoelasticity, and the inotropic state of the myocardium. Diastolic abnormalities can be conceptualized by using pressure-volume loops that illustrate myocardial work and both diastolic and systolic pressure-volume relationships. The pressure-volume model is an educational tool that can be used to demonstrate isolated changes in preload, afterload, inotropy, and lusitropy and their interaction.
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Harnavi, Harun, Febrianti Ika Kurnia, and Kam Alexander. "Correlation of Serum Fibroblast Growth Factor 23 With Left Ventricular Diastolic Function in Chronic Kidney Patients." Eduvest - Journal of Universal Studies 2, no. 9 (2022): 1894–904. http://dx.doi.org/10.36418/eduvest.v2i8.601.
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Chronic Kidney Disease (CKD) is one of most common world’s health problems with constantly increasing prevalence and many complications, and cardiovascular is one of them. The earliest cardiovascular damage that can be seen is left ventricular diastolic dysfunction. In patients with CKD, there will be mineral metabolism disorders, including phosphate. Persistently increased phosphate in CKD will cause rising in Fibroblast Growth Factor 23 (FGF23) that regulates phosphate in the circulation. High level of FGF23 will directly damage the heart and stimulates cardiac remodeling that will result in cardiomyocyte damage, atherosclerosis and intramyocardial cells fibrosis. This will cause myocardial stiffness and diastolic dysfunction. The purpose of the study is to discover correlation between Fibroblast Growth Factor 23 (FGF23) serum and left ventricle diastolic function in patients with chronic kidney disease. This is an observational study with cross-sectional methods. The sample is 30 patients diagnosed with chronic kidney disease (CKD). Patients are evaluated for Fibroblast Growth Factor 23 (FGF23) level in their serum, assessed the left ventricle diastolic function by measuring early diastolic velocity of the left ventricle (lateral e’) using echocardiography.There is significantly increased of FGF23 serum levels and decreased of lateral e’ value in chronic kidney disease case. There’s also a strong correlation between FGF23 serum and filtration glomerulus rate (LFG) (p<0.05), and a strong correlation between FGF23 serum level with lateral e’ as a component of left ventricle diastolic function. There’s a strong correlation between FGF23 with left ventricle diastolic function in patients with CKD.
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Harnavi, Harun, Febrianti Ika Kurnia, and Kam Alexander. "Correlation of Serum Fibroblast Growth Factor 23 With Left Ventricular Diastolic Function in Chronic Kidney Patients." Eduvest - Journal of Universal Studies 2, no. 9 (2022): 1894–904. http://dx.doi.org/10.59188/eduvest.v2i9.601.
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Chronic Kidney Disease (CKD) is one of most common world’s health problems with constantly increasing prevalence and many complications, and cardiovascular is one of them. The earliest cardiovascular damage that can be seen is left ventricular diastolic dysfunction. In patients with CKD, there will be mineral metabolism disorders, including phosphate. Persistently increased phosphate in CKD will cause rising in Fibroblast Growth Factor 23 (FGF23) that regulates phosphate in the circulation. High level of FGF23 will directly damage the heart and stimulates cardiac remodeling that will result in cardiomyocyte damage, atherosclerosis and intramyocardial cells fibrosis. This will cause myocardial stiffness and diastolic dysfunction. The purpose of the study is to discover correlation between Fibroblast Growth Factor 23 (FGF23) serum and left ventricle diastolic function in patients with chronic kidney disease. This is an observational study with cross-sectional methods. The sample is 30 patients diagnosed with chronic kidney disease (CKD). Patients are evaluated for Fibroblast Growth Factor 23 (FGF23) level in their serum, assessed the left ventricle diastolic function by measuring early diastolic velocity of the left ventricle (lateral e’) using echocardiography.There is significantly increased of FGF23 serum levels and decreased of lateral e’ value in chronic kidney disease case. There’s also a strong correlation between FGF23 serum and filtration glomerulus rate (LFG) (p<0.05), and a strong correlation between FGF23 serum level with lateral e’ as a component of left ventricle diastolic function. There’s a strong correlation between FGF23 with left ventricle diastolic function in patients with CKD.
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Aslan, Eyup, Ahmet Sert, Muammer Buyukinan, et al. "Left and right ventricular function by echocardiography, tissue Doppler imaging, carotid intima-media thickness, and asymmetric dimethyl arginine levels in obese adolescents with metabolic syndrome." Cardiology in the Young 29, no. 3 (2019): 310–18. http://dx.doi.org/10.1017/s1047951118002329.
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AbstractPurposeThe aim of our study was to assess left ventricle and right ventricle systolic and diastolic functions in obese adolescents with metabolic syndrome using conventional echocardiography and pulsed-wave tissue Doppler imaging and to investigate carotis intima-media thickness, and asymmetric dimethyl arginine levels.MethodsA total of 198 obese adolescents were enrolled in the study. The obese patients were divided into metabolic syndrome group and non-metabolic syndrome group. All subjects underwent laboratory blood tests, including asymmetric dimethyl arginine, complete two-dimensional, pulsed, and tissue Doppler echocardiography, and measurement of the carotid intima-media thickness.ResultsObese adolescents were characterised by enlarged left end-diastolic, end-systolic and left atrial diameters, thicker left and right ventricular walls compared with non-obese adolescents. The metabolic syndrome group had normal left ventricle systolic function, impaired diastolic function, and altered global systolic and diastolic myocardial performance. In the metabolic syndrome obese group patients, left ventricle mass was found positively correlated with body mass index, waist and hip circumferences, diastolic blood pressure, age, and waist-to-hip circumference ratio. The carotid intima-media thickness was found positively correlated with waist and hip circumferences and total cholesterol levels. Asymmetric dimethyl arginine levels were found positively correlated with systolic blood pressure, waist-to-hip circumference ratio, and diastolic blood pressure.ConclusionsThe results of this study demonstrate that metabolic syndrome in adolescence is associated with significant changes in myocardial geometry and function. In addition, it has been associated with a high level of asymmetric dimethyl arginine concentration and thicker carotid intima-media thickness reflecting endothelial dysfunction.
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Freire, Cláudia Maria V., Ana Luiza M. T. Moura, Márcia de Melo Barbosa, Lucas José de C. Machado, Anelise Impeliziere Nogueira, and Antônio Ribeiro-Oliveira Jr. "Left ventricle diastolic dysfunction in diabetes: an update." Arquivos Brasileiros de Endocrinologia & Metabologia 51, no. 2 (2007): 168–75. http://dx.doi.org/10.1590/s0004-27302007000200005.
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Diabetes mellitus, a disease that has been reaching epidemic proportions, is an important risk factor to the development of cardiovascular complication. Diabetes causes changes within the cardiac structure and function, even in the absence of atherosclerotic disease. The left ventricular diastolic dysfunction (VE) represents the earliest pre-clinical manifestation of diabetic cardiomyopathy, preceding the systolic dysfunction and being able to evolve to symptomatic heart failure. The doppler echocardiography has emerged as an important noninvasive diagnostic tool, providing reliable data in the stages of diastolic function, as well as for systolic function. With the advent of recent echocardiographic techniques, such as tissue Doppler and color M-mode, the accuracy in identifying the moderate diastolic dysfunction, the pseudonormal pattern, has significantly improved. Due to cardiometabolic repercussions of DM, a detailed evaluation of cardiovascular function in diabetic patients is important, and some alterations may be seen even in patients with gestational diabetes.
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Ozawa, Katsusuke, Jun Murotsuki, Susumu Miyashita, et al. "Assessing Fetal Cardiac Function by Measuring Myocardial Radial Velocity Using the Phased-Tracking Method." Fetal Diagnosis and Therapy 38, no. 2 (2015): 126–34. http://dx.doi.org/10.1159/000371514.
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Objective: This study aimed to assess the cardiac function of healthy and pathological fetuses by measuring radial velocity using phased tracking (PT). Based on phase differences, PT allows the displacement of a specified point to be detected with improved spatial and temporal resolution. Methods: PT was used to assess cardiac radial velocity in the basal free wall of the left and right ventricles in 134 healthy fetuses, 10 second-trimester intrauterine growth-restricted (IUGR) fetuses, and 10 recipient twins with twin-to-twin transfusion syndrome (TTTS). Maximum velocities were measured in systole and early diastole. Results: Maximum radial velocity was successfully measured in 126 healthy fetuses (94%) at gestational ages of 16-40 weeks. Systolic and early diastolic maximum velocities increased with gestational age in both ventricles. As compared with controls, IUGR fetuses had significantly lower early diastolic maximum velocities in the right ventricle, and recipient twins with TTTS had significantly lower systolic and early diastolic maximum velocities in both ventricles. Conclusions: PT demonstrated right ventricular diastolic dysfunction in second-trimester IUGR fetuses as well as systolic and diastolic dysfunctions in both ventricles in recipient twins with TTTS. PT could be useful for evaluating fetal cardiac radial function.
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Savio, Federica, Domenico Sirico, Giada Mazzon, et al. "Cardiac Mechanics Evaluation in Preschool-Aged Children with Preterm Birth History: A Speckle Tracking and 4D Echocardiography Study." Journal of Clinical Medicine 13, no. 10 (2024): 2762. http://dx.doi.org/10.3390/jcm13102762.
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Background: The premature-born adult population is set to grow significantly, and prematurity has emerged as an important cardiovascular risk factor. We aimed to comprehensively assess cardiac mechanics and function in a cohort of ex-preterm preschoolers. Methods: Ex-preterm children (<30 weeks of gestation), aged 2 to 5 years, underwent transthoracic 2D, speckle-tracking, and 4D echocardiography. The findings were compared with 19 full-term children. Results: Our cohort of 38 children with prematurity history showed a normal morpho-functional echocardiographic assessment. However, compared to controls, the indexed 3D end-diastolic volumes of ventricular chambers were reduced (left ventricle 58.7 ± 11.2 vs. 67.2 ± 8.5 mL/m2; right ventricle 50.3 ± 10.4 vs. 57.7 ± 11 mL/m2; p = 0.02). Left ventricle global and longitudinal systolic function were worse in terms of fraction shortening (32.9% ± 6.8 vs. 36.5% ± 5.4; p = 0.05), ejection fraction (59.2% ± 4.3 vs. 62.3% ± 3.7; p = 0.003), and global longitudinal strain (−23.6% ± 2.4 vs. −25.5% ± 1.7; p = 0.003). Finally, we found a reduced left atrial strain (47.4% ± 9.7 vs. 54.9% ± 6.8; p = 0.004). Conclusions: Preschool-aged ex-preterm children exhibited smaller ventricles and subclinical impairment of left ventricle systolic and diastolic function compared to term children. Long-term follow-up is warranted to track the evolution of these findings.
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Flaubert, Mark, Margaret H. Lauerman, Daniel Haase, et al. "Does right ventricle dysfunction represent cardiac frailty in critically ill trauma patients?" Trauma 22, no. 1 (2018): 18–25. http://dx.doi.org/10.1177/1460408618794215.
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Introduction Cardiac function includes left ventricle ejection fraction, right ventricle function, diastolic function, and multiple markers of cardiac outflow. Markers of cardiac function associated with mortality are unknown. The purpose of this study was to determine markers of cardiac function associated with mortality in the elderly which represent cardiac frailty and the relative importance of these many measurements of cardiac function when compared with each other. Methods A retrospective review of patients who underwent focused rapid echocardiographic evaluations was performed from 2009 to 2014. Focused rapid echocardiographic evaluations are echocardiographic exams focusing on cardiac function rather than structure. Results Overall, 513 trauma patients received focused rapid echocardiographic evaluations. In elderly patients, mortality increase of 33.9% was seen with left ventricle ejection fraction less than 30% (p = 0.05), 28.5% with moderate right ventricle dysfunction (p = 0.03), and 18.5% with velocity time integral less than 18 cm (p = 0.02). Any level of diastolic dysfunction, cardiac output of less than 4 l/min, and cardiac index less than 2.5 l/min/m2 was not significantly associated with increased mortality in the elderly (not significant [NS] for all). In younger patients, a mortality increase of 68.1% was seen with grade 3–4 diastolic dysfunction (p<0.001) and 14.6% with velocity time integral less than 18 cm (p = 0.02), with right ventricle dysfunction, decreased left ventricle ejection fraction, cardiac output less than 4 l/min, and cardiac index less than 2.5 l/min/m2 not associated with mortality (NS for all). In logistic regression for elderly patients, only moderate right ventricle dysfunction was associated with mortality (odds ratio 4.321, 95% confidence interval 1.451–12.866, p = 0.009). Conclusions Markers of cardiac function associated with mortality vary with age. Right ventricle dysfunction may represent cardiac frailty, while diastolic dysfunction and left ventricle ejection fraction likely do not.
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Kamal, Hanan M., Hoda A. Atwa, Omar M. Saleh, and Faten A. Mohamed. "Echocardiographic evaluation of cardiac structure and function in obese Egyptian adolescents." Cardiology in the Young 22, no. 4 (2011): 410–16. http://dx.doi.org/10.1017/s1047951111001910.
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AbstractObjectiveThe objective of this study was to detect structural and functional changes in the left and right ventricles in obese Egyptian adolescents.Methods and resultsAnthropometric and echocardiographic parameters, including tissue Doppler imaging, were obtained from 70 obese adolescents with average body mass index of 34 plus or minus 3.8 and compared with 50 age- and sex-matched controls, with a body mass index of 21.6 plus or minus 1.9. Cardiac dimensions, stroke volume, left ventricular and right ventricular systolic and diastolic functions were evaluated. The obese group had a higher end-diastolic septal and posterior wall thickness and left ventricular mass index than the non-obese group. Body mass index, mid-arm and hip circumference values showed significant correlations with these echocardiographic variables. Systolic and diastolic functions of the left ventricle were normal in both groups, although stroke volume was high in the obese group. The right ventricle tissue Doppler parameters were similar in both groups. However, the S wave of the septal/lateral tricuspid valve annulus was reduced in the obese group, but not to the level reflecting systolic dysfunction. This was inversely correlated with hip, waist, and mid-arm circumference. Stepwise multiple regression analysis showed that the mid-arm and hip circumference followed by the body mass index are significant predictors of these early cardiac abnormalities.ConclusionLeft ventricular hypertrophy is present in obese children, although both systolic and diastolic functions are normal. Tissue Doppler imaging revealed a minor, but still significant, reduction in the right ventricular systolic function. Mid-arm and hip circumference are predictors of left ventricular hypertrophy.
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Hayashida, Wataru, Toshiaki Kumada, Masashi Kambayashi, Noboru Ishikawa, and Shigetake Sasayama. "Early diastolic regional function of the hypertrophied left ventricle." International Journal of Cardiology 53, no. 2 (1996): 153–62. http://dx.doi.org/10.1016/0167-5273(95)02534-0.
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IŞIK, İsmet, Yalçın KEPEKÇİ, Vahap OKAN, Şebnem AKTARAN, and Ahmet SEZER. "Evaluation of Cardiovascular Autonomic Neuropathy in Niddm with Radionuclide Ventriculography." European Journal of Therapeutics 9, no. 1, 2 (1998): 7–13. http://dx.doi.org/10.58600/eurjther.1998-9-1-2-1434-arch.
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The aim of our study is to observe the relation between cardiovascular autonomic neuropathy (CON) in noninsulin dependent diabetes mellitus (NlDDM) and the left ventricle functions. We have three groups in this study. ln the first group of 30 patients with anamnestic diabetic ages between 0-1O years. The second group, 30 patients whose diabetes ages are older than 1O years. ln the control group there are 20 healty peoples. CON tests was performed in every patient. The left ventricle functions were observed by radionuclid ventriculography (RNV). When CON ratio in the diabetes mellitus (DM) groups is compared with, the control group significant difference was found between them (p<0.05). When the DM groups are compared among themselves, it was realised that there is a statistically significant difference (p<0.01). ln the DM during the time increased the frequency and severity of CON increased also. When the systolic function of the left ventricle was compared among themselves and with the control group, no statistical significant difference was observed (p<0.05). lt's concluded that DM doesn't effect systolic function of the left ventricle. Significant dif.ference is fouııd between the DM groups and the control group (p<0.01 ). It's found that DM effect diastolic fuııctioıı of the left ventricle in the early period diastolic disfunction emerges. Besides, in the %85 of the patients with the diastolic disfunction CON is found. Lastly it is concluded that as the severity of CON increases, the possibility ta observe the frequency of diastolic disfunction alsa increases.
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Dai, Yuanliang. "VALUE OF ECHOCARDIOGRAPHIC DIASTOLIC FUNCTION REACTIVITY UNDER EXERCISE LOAD." Revista Brasileira de Medicina do Esporte 28, no. 2 (2022): 159–61. http://dx.doi.org/10.1590/1517-8692202228022021_0477.
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ABSTRACT Introduction: Left ventricular diastolic dysfunction is one of the important long-term survival and prognosis factors in patients with coronary heart disease. Objective: To evaluate the diastolic function of the left ventricle in patients with coronary heart disease (CHD) using 3D speckle tracking echocardiography (3D-STE). Methods: Full volume images of four apical cavities were collected, and 4D Auto LVQ software was used for offline analysis to obtain longitudinal strain (GLS), circumferential strain (GCS), area strain (GAS) and radial strain (GRS) of the left ventricle as a whole (four three-dimensional strain indicators). Results: The receiver operating characteristic (ROC) curve analysis showed that the sensitivity and specificity of GLS in predicting left ventricular diastolic dysfunction were both 68% at −15.5%. The sensitivity and specificity of GCS for predicting left ventricular diastolic dysfunction at −17.5% were 76% and 81%, and those of GAS at −29.5% were 84% and 68%, respectively. Conclusions: The strain parameters of 3D-STE can be used to predict LVEDP in patients with coronary heart disease with normal left ventricular ejection fraction, and can be used as a new ultrasonic diagnostic index to evaluate left ventricular diastolic function in patients. Level of evidence II; Therapeutic studies - investigation of treatment results.
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Galyavich, A. S., and A. Yu Rafikov. "Evaluation of the right ventricular ejection fraction according to multislice computed tomography in patients with pulmonary embolism." Kazan medical journal 96, no. 6 (2015): 901–5. http://dx.doi.org/10.17750/kmj2015-901.
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Aim. Evaluation of the global systolic function of the right ventricle according to multislice computed tomography in patients with pulmonary embolism.
 Methods. 37 people aged 31 to 75 years (20 women and 17 men, mean age 55±12 years) were examined. The study group included 15 patients without clinical or instrumental signs of congenital heart disease and myocardial infarction of the left and right ventricles, with signs of pulmonary embolism according to multislice computed tomography. The control group included 22 patients. Tomographic analysis of end-diastolic volume, ejection fraction of the left and right ventricles was performed during noninvasive multislice computed tomography - coronary angiography, angiopulmonography. The study was conducted on a 64-helical computed tomography Aquillon 64 (Toshiba, Japan).
 Results. Analyzing group medians in patients with pulmonary embolism there was a decrease of the right ventricular ejection fraction and end-diastolic volume of the left ventricle (р
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Gritsenko, Olesia V., Galina A. Chumakova, and Elena V. Trubina. "Features of speckle tracking echocardiography for diagnosis of myocardial dysfunction." CardioSomatics 12, no. 1 (2021): 5–10. http://dx.doi.org/10.26442/22217185.2021.1.200756.
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Despite the undoubted success in the diagnosis of heart failure using echocardiography, the issue of detecting diastolic dysfunction of the left ventricle of the heart in the early stages remains insufficiently studied. The article describes a non-invasive ultrasound method for evaluating myocardial function, which allows early detection of left ventricle diastolic dysfunction due to myocardial fibrosis.
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Pinheiro, Bruna S., Patrícia M. Barrios, Liliane T. Souza, and Têmis M. Félix. "Echocardiographic study in children with osteogenesis imperfecta." Cardiology in the Young 30, no. 10 (2020): 1490–95. http://dx.doi.org/10.1017/s1047951120002474.
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AbstractBackground:Osteogenesis imperfecta is a collagen type I bone disorder. Recently, extra-skeletal manifestations have been described, including many cardiovascular alterations. This study aims to report echocardiogram study in children with osteogenesis imperfecta compared to a control group.Methods:A cross-sectional comparative study took place in the Reference Center for Treatment of Osteogenesis Imperfecta in Southern Brazil. Fifty-four patients with osteogenesis imperfecta were paired with 54 controls, based on body surface area, and echocardiogram findings were compared.Results:All cases were asymptomatic for cardiac manifestations. The case group presented significant larger values in aortic diameter, left atrium diameter, left ventricule end-diastolic diameter, left ventricule end-systolic diameter, and right ventricle diameter compared with the control group. The analysis considering the severity of osteogenesis imperfecta shows that in mild osteogenesis imperfecta, the aortic diameter (p < 0.001), left atrium diameter (p = 0.002), left ventricule end-diastolic diameter (p = 0.001), left ventricule end-systolic diameter (p = 0.026), and right ventricle diameter (p < 0.001) were significantly larger than in the control group. Patients with moderate/severe osteogenesis imperfecta had similar results, with aortic diameter (p < 0.001), left atrium diameter (p < 0.001), left ventricule end-diastolic diameter (p = 0.013), and left ventricule end-systolic diameter (0.004) statistically larger than controls. Twenty-six (48.1%) of the cases had physiological tricuspid regurgitation and in controls this finding was observed in eight (14.8%) (p < 0.001).Conclusion:Children with osteogenesis imperfecta presented cardiac function within the normal pattern, but dimensions of left ventricular dimensions were increased compared to the ones of the controls.
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Nugraha, Fauzi Akira, M. Rizki Akbar, Toni M. Aprami, and Januar W. Martha. "Correlation between Leptin with Diastolic Function in Young Adult Obesity." ACI (Acta Cardiologia Indonesiana) 5, no. 1 (2019): 54. http://dx.doi.org/10.22146/aci.44552.
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Background: Obesity is one of the global health problems with increasing prevalence, and the complication is related to the alteration of the left ventricle. An obese person without symptoms has impaired diastolic function compares to a normal population, but the mechanism is still unclear. One of the evolving theories is caused by chronic inflammation, characterized by the increase of proinflammatory adipocytokines in an obese person. Leptin is a chronic inflammatory marker which is synthesized by all adipose tissues and has a positive correlation with the body mass index. Leptin level are influenced by age except young adult group. The aim of this study is to investigate the correlation between leptin level and diastolic function of the left ventricle in youngadult obese.Method: This study was conducted in a single centre with cross-sectional design. The subject of this study consists of all young adult obese, worked in Dr. Hasan Sadikin General Hospital, between June-August 2018. The diastolic function of the left ventricle was measured by examining the ventricle relaxation (E/mean e’) by tissue doppler imaging method. The examination of leptin level was done by sandwich-ELISA testmethod. Pearson correlation test was done to assess the correlation between those two.Result: This study consisted of 38 patients with the mean of age 30.75±7.25 years old, 68% were males. The mean score of E/mean e’ was 6.49±3.02 ng/mL and the median of leptin was 13.95 (9.1–25.4) mg/L. After data log transformation of leptin was done, there was a significant positive correlation (r= 0.5892, p<0.001) between leptin level and E/mean e’.Conclusion: There was a significant correlation between the level of leptin and diastolic function of the left ventricle in young adult obese.
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Adjagba, Philippe M., Gaston Habib, Nancy Robitaille, et al. "Impact of sickle cell anaemia on cardiac chamber size in the paediatric population." Cardiology in the Young 27, no. 5 (2016): 918–24. http://dx.doi.org/10.1017/s1047951116001633.
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AbstractPurposeSickle cell disease is known to cause various degrees of vasculopathy, including impact on heart function. The aims of this single-centre, retrospective study were to assess cardiac chamber size and function and the relationship with haematological indices such as haemoglobin, aspartate aminotransferase, reticulocytosis and bilirubin, lactate dehydrogenase in sickle cell disease.MethodsRight ventricle and left ventricle diastolic diameters, left ventricle mass estimate, left ventricle shortening fraction, myocardial performance index, and an index of myocardial relaxation (E/E’) were calculated and correlated with haematological parameters.ResultsA total of 110 patients (65% haemoglobin SS, 29% haemoglobin SC) were studied at a mean age of 12.14±5.26 years. Right ventricle dilatation and left ventricle dilatation were present in 61.5 and 42.9%, respectively. Left ventricle mass was abnormal in 21.9%; all patients had normal myocardial performance index, 31.4% had abnormal E/E’, and left ventricle shortening fraction was low in 38.1%. Cardiac dilatation was best correlated with haemoglobin, aspartate aminotransferase, reticulocytosis and bilirubin. Best subset regression analysis yielded significant additional prediction for right ventricle or left ventricle dilatation with haemoglobin, bilirubin, and lactate dehydrogenase. Abnormal E/E’ was solely predictable with haemoglobin level. Hydroxyurea-treated patients had improved diastolic function.ConclusionRight ventricle dilatation was more prevalent than left ventricle dilatation. The long-term consequences of right ventricular dilatation, clinical consequences, and association with pulmonary vasculopathy need to be further determined.
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Daniuk, I. O., and N. G. Ryndina. "Immune-Inflammatory Predictors of Diastolic Dysfunction of Left Ventricle in Patients with Rheumatoid Arthritis Combined with Hypertension." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 6, no. 4 (2021): 83–90. http://dx.doi.org/10.26693/jmbs06.04.083.
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Hypertension is the most common concomitant disease in patients with rheumatoid arthritis. Diastolic dysfunction of left ventricle is an important predictor of chronic heart failure, which can be asymptomatic for a long time. Therefore, it is advisable to detect diastolic dysfunction of left ventricle as early as possible, which can slow the progression of chronic heart failure. The purpose of the study was to determine the value of lipid peroxidation, endothelial function and systemic inflammatory response markers for diagnostic of diastolic dysfunction of left ventricle and for diagnostic of pericardial effusion in patients with rheumatoid arthritis combined with hypertension. Materials and methods. 93 patients with rheumatoid arthritis in combination with stage II hypertension were studied. The ultrasound examination of heart was performed. The serum laboratory markers of lipid peroxidation, concentration of pro-inflammatory cytokines, markers of endothelial function were determined. Results and discussion. Signs of diastolic dysfunction of left ventricle were found in 79 patients and no signs of diastolic dysfunction were found in 14 patients. It was detected that there was a significant increase of concentration of asymmetric dimethylarginine by 16.3%, interleukin-1β by 35.3%, interleukin-10 by 24.3%, the ratio of interleukin-1β / interleukin-10 by 62.0%, C-reactive protein by 52.6% and there was a significant decrease of total nitric oxide metabolites by 36.9%, nitrires by 37.5% and nitrates by 37.0% in patients with signs of diastolic dysfunction of left ventricle compared to the patients without diastolic dysfunction of left ventricle (p <0.01). It was found that the levels of isolated double bonds, diene conjugates, diene ketones, schiff bases and malonic aldehyde in patients with diastolic dysfunction of left ventricle were significantly higher by 24.4%, 25.2%, 20.4%, 17.6% and 21.4% respectively compared to the corresponding markers in patients without signs of diastolic dysfunction of left ventricle (p <0.01). The levels of vitamin A, vitamin E and catalase in patients with diastolic dysfunction of left ventricle were significantly lower by 18.2%, 27.4% and 13.4% compared to the corresponding markers of patients with normal left ventricle diastolic function (p <0.01). The highest predictor value for the diagnostic of diastolic dysfunction of left ventricle was detected in interleukin-1β area under the ROC curve 0.882, sensitivity 72.15% and specificity 100%, 95% CI [0.798-0.939] at the optimal distribution point >9.67 pg/ml and in asymmetric dimethylarginine area under the ROC curve 0.879 sensitivity 75.95% and specificity of 100%, 95% CI [0.795-0.937] at the optimal distribution point >0.715 μmol/l. In 17 (18.28%) patients, the effusion in the pericardial cavity was detected. It was detected that there was a significant increase of isolated double bonds by 18.65%, diene conjugates by 19.73%, diene ketones by 25.25%, schiff bases by 20%, malonic aldehyde by 26.76% and there was a significant decrease of vitamin A by 38.4%, vitamin E by 55.4% and catalase by 37.2% in patients with effusion in the pericardial cavity. The significant increase of asymmetric dimethylarginine was detected by 25.25%, interleukin-1β – by 52.24%, interleukin-10 – by 15.76%, the ratio of interleukin-1β / interleukin-10 – by 38.86% and C-reactive protein – by 26.9% in patients with effusion in the pericardial cavity. In addition, patients with cavity effusion have significant decrease of nitric oxide metabolites by 25.0%, nitrires by 30.0% and nitrates by 11.11% compared to the patient without effusion. The highest predictor value for the detection of effusion in the pericardial cavity was found in asymmetric dimethylarginine area under the ROC curve 0.913, 95% CI area under the ROC curve [0.836-0.961] at the optimal distribution point >0.841 μmol/l, sensitivity 94.12% and specificity 85.53%. Conclusion. The markers, which have the highest prognostic value for diagnostic of diastolic dysfunction of left ventricle in patients with rheumatoid arthritis combined with hypertension, are interleukin-1β and asymmetric dimethylarginine. In addition, asymmetric dimethylarginine has the highest predictor value for detecting fluid in the pericardial cavity
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V. G. Deinega and V. V. Kryvenko. "Characteristics of the morphofunctional state of the heart, vessels and the endothelial function in patients combined course of chronic obstructive pulmonary disease and arterial hypertension." Bukovinian Medical Herald 17, no. 2 (66) (2013): 41–45. http://dx.doi.org/10.24061/2413-0737.xvii.2.66.2013.60.
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The study involved 101 patients with chronic obstructive pulmonary disease (COPD), arterial hypertension of stage II (AH) and their combined course. Using echocardiography and Doppler methods we evaluated the parameters of the systolic and diastolic function of the left and right ventricle, the thickness of the intima-media complex (TIMC) of the left and right common carotid artery (CCA), the parameters of the state of the endothelium. A statistically significant increase of the right and left TIMC, a decrease of the index of endothelium-dependent vasodilation, abnormalities of the systolic and diastolic function of the left and right ventricles in patients with a combined course of COPD and AH as compared with those who had COPD or AH have been detected.
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Kuryata, O., A. Zabida, and O. Sirenko. "Galectin-3, advanced glycated end-products serum levels, endothelial function and cardiac hemodynamics in post infarction heart failure patients with reduced and preserved ejection fraction." Medicni perspektivi 23, no. 2 part 1 (2018): 69–74. https://doi.org/10.26641/2307-0404.2018.2(part1).129519.
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Epidemiological studies have reported that the rate of signs and symptoms of heart failure after myocardial infarction is approximately 25%. In addition, approximately 40% of myocardial infarctions are accompanied by left ventricular systolic dysfunction. Aim.. Aim of the study is to evaluate serum levels of galactin-3, AGEs and endothelial function, cardiac hemodynamics in post infarction chronic heart failure patients with different ejection fraction. Materials and methods. All patients are divided into two main groups according to ejection fraction:1<sup>st</sup> group-20 patients with chronic heart failure with preserved ejection fraction, 2<sup>nd</sup> group-15 patients with chronic heart failure and reduced ejection fraction. Standard laboratory blood tests for erythrocyte sedimentation rate, haematological parameters, lipid profile, glucose, renal function, echocardiographic examination, endothelial function determine were performed for all patients. AGEs and galectin-3 serum levels were determined. Results. Patients with chronic heart failure and reduced ejection fraction and myocardial infarction in anamnesis had significantly increased left ventricle diastolic volume, left ventricle systolic volume,left ventricle diastolic dimension and left ventricle systolic dimension (p<0.05).AGEs serum level mildly increased in both groups.Galectin-3 level was significantly higher in pts with chronic heart failure and reduced ejection fraction(p < 0.05)and was correlated with age(R=0.74, p<0.05), left ventricle end diastolic volume (R=0.57, p<0.05), left ventricle end diastolic dimension (R=0.48, p<0.05), triglycerides level (R=0.45, p < 0.05). Most of the patients with chronic heart failure with myocardial infarction in anamnesis had endothelial dysfunction, the FMD% level was significantly higher in patients with preserved ejection fraction(p<0.05). Conclusions. Patients with chronic heart failure and reduced ejection fraction are characterized by significantly higher levels of galectin-3, endothelial dysfunction frequency, cardiac hemodynamics abnormalities.
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Qin, Shiyang, and Rui Zhang. "Clinical Application of Echocardiography in Evaluating Left Ventricular Diastolic Function in Patients with Acute Pulmonary Embolism." Computational and Mathematical Methods in Medicine 2022 (May 11, 2022): 1–9. http://dx.doi.org/10.1155/2022/3483390.
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Objective. To explore the clinical application of echocardiography in assessing left ventricular diastolic function in patients with acute pulmonary embolism (APE). Methods. About 90 patients with APE treated in our hospital from March 2016 to March 2019 were enrolled as the study group. The enrolled patients were assigned into three groups in accordance with the risk stratification of APE, with 30 patients in each group, including high-risk group, medium-risk group, and low-risk group. Approximately 90 healthy persons who underwent physical examination in the same period were enrolled as the control group. The two groups were used to analyze the clinical value of echocardiography in evaluating left ventricular diastolic function in patients with APE and to explore the correlation between left ventricular diastolic function and different risk stratification of APE. Results. First of all, we compared the side values of echocardiography. Compared to the control group, right ventricular end-diastolic diameter/left ventricular end-diastolic diameter (RVED/LVED) and pulmonary artery systolic pressure (PASP) in the study group were higher, while left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), left ventricular volume per stroke (LVSV), and left ventricular ejection fraction (LVEF) in the study group were lower ( P < 0.05 ). Secondly, we compared the echocardiographic side values of patients with different APE risk stratifications: (1) RVED/LVED, PASP: low ‐ risk group < medium ‐ risk group < high ‐ risk group ; (2) LVEDV, LVESV, LVSV, LVEF: low ‐ risk group > medium ‐ risk group > high ‐ risk group ( P < 0.05 ). The routine echocardiographic findings of APE patients: M-type left ventricular wave group of pulmonary embolism (PE) indicated right ventricular enlargement and interventricular septum shifted to the left ventricle; short-axis section of PE artery indicated thrombosis at the opening of the right pulmonary artery (indicated by arrow); long-axis section of the left ventricle of PE indicated right ventricular enlargement (RV 3.5 cm, LV 3.9 cm); four-chamber view of PE indicated enlargement of the right atrium and the right ventricle, and interventricular septum shifted like left ventricle. In terms of mitral annulus displacement, early diastolic ESD and ELD in the study group were lower compared to those in the normal control group, while late diastolic ASD and ALD in the study group were higher compared to those in the normal control group ( P < 0.05 ). The results of Pearson correlation analysis indicated that there was a positive correlation between RVED/LVED, PASP, and APE risk stratification, while APE risk stratification was negatively correlated with LVEDV, LVESV, LVSV, and LVEF ( P < 0.05 ). Conclusion. Echocardiography attaches importance to the evaluation of left ventricular diastolic function in APE. The side value of echocardiography can sensitively reflect the changes of left ventricular diastolic function in APE. The predictive value in the diagnosis of APE is better than other traditional parameters of left ventricular diastolic function, especially in patients with different APE risk stratifications. There is a remarkable correlation between the changes of left ventricular diastolic function and different APE risk stratifications. Echocardiographic measurement can be employed to assess left ventricular diastolic function in APE, which can be developed in clinical treatment and prognosis evaluation to provide a new evaluation method.
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Titova, O. N., N. A. Kuzubova, A. L. Aleksandrov, V. E. Perley, and A. Yu Gichkin. "Pulmonary and cardiac hemodynamics in COPD and cystic fibrosis by Doppler echocardiography." Russian Medical Inquiry 5, no. 7 (2021): 456–61. http://dx.doi.org/10.32364/2587-6821-2021-5-7-456-461.
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Aim: to assess the functionality of the right heart in patients with chronic obstructive pulmonary disease (COPD), mixed cystic fibrosis (CF), and cystic fibrosis lung disease by Doppler echocardiography. Patients and Methods: 30 adults with CF and 82 adults with COPD underwent ultrasonography to evaluate pulmonary and cardiac hemodynamics. All patients were divided into four groups based on the presence/absence of clinical signs of right ventricular failure and pulmonary hypertension. Results: in COPD, diastolic dysfunction of the right heart can be subclinical preceding systolic impairment. Right ventricular hypertrophy and failure in CF occur in relatively low pulmonary artery pressure. Thus, in systolic pulmonary pressure less than 40–50 mm Hg, hypertrophy and dilation were concomitant. As the diastolic function of the right ventricle worsens, right atrial contractility increases while the ratio of left ventricular filling velocities during the early atrial diastole and systole reduces in patients with CF. Conclusion: in severe COPD, significant structural and functional impairments of the right ventricle occur. Compensatory potentialities of the right and left ventricles exhaust, thereby providing the conditions for the progression of heart failure and the development of the chronic pulmonary heart. In CF, diastolic dysfunction of the right heart often precedes systolic dysfunction, as illustrated by changes in the proportion of various filling phases of the right ventricle. In right ventricular diastolic dysfunction, an increase in right atrial contractility occurs that reduces only in severe decompensation of the chronic pulmonary heart. KEYWORDS: chronic obstructive pulmonary disease, cystic fibrosis, echocardiography, Doppler cardiography, pulmonary hypertension, right ventricular failure, diastolic function. FOR CITATION: Titova O.N., Kuzubova N.A., Aleksandrov A.L. et al. Pulmonary and cardiac hemodynamics in COPD and cystic fibrosis by Doppler echocardiography. Russian Medical Inquiry. 2021;5(7):456–461 (in Russ.). DOI: 10.32364/2587-6821-2021-5-7-456-461.
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Peregud-Pogorzelska, Małgorzata, Małgorzata Zielska, Miłosz Piotr Kawa, et al. "Association between Light-Induced Dynamic Dilation of Retinal Vessels and Echocardiographic Parameters of the Left Ventricular Function in Hypertensive Patients." Medicina 56, no. 12 (2020): 704. http://dx.doi.org/10.3390/medicina56120704.
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Background and Objectives: The goal was to evaluate the association of dynamic retinal vessel analysis (DVA) with echocardiographic parameters assessing systolic and diastolic function of the left ventricle in hypertension (HT) patients with preserved left ventricle ejection fraction. Materials and Methods: This observational retrospective study recruited 36 patients with HT and 28 healthy controls. Retinal vessel diameter and reactions to flicker light were examined. Each patient was examined with echocardiography to assess left ventricular systolic and diastolic function. Results: Multivariate analysis revealed that hypertension was an independent factor associated with lower flicker-induced arterial vasodilatation (β = −0.31, p = 0.029). In the HT group, there was a significant positive association between left ventricular ejection fraction and flicker-induced arterial vasodilation (Rs = +0.31, p = 0.007). Additionally, end-diastolic left ventricular diameter negatively correlated with both arterial (Rs = −0.26, p = 0.02) and venous (Rs = −0.27, p = 0.02) flicker responses. Additionally, the echocardiographic characteristics of the left atrium (LA) remodeling in the course of HT, including the area of the LA and its antero-posterior dimension, were both negatively correlated with the arterial flicker response (Rs = −0.34, p = 0.003; Rs = −0.33, p = 0.004, respectively). From tissue Doppler parameters, the left ventricular filling index E/e’ negatively correlated with AVR (arteriovenous ratio) values (Rs = −0.36, p = 0.002). Conclusions: We revealed that systolic and diastolic function of the left ventricle in hypertensive patients is associated with retinal microvascular function.
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Stewart, Kelley C., John C. Charonko, Casandra L. Niebel, William C. Little, and Pavlos P. Vlachos. "Left ventricular vortex formation is unaffected by diastolic impairment." American Journal of Physiology-Heart and Circulatory Physiology 303, no. 10 (2012): H1255—H1262. http://dx.doi.org/10.1152/ajpheart.00093.2012.
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Normal left ventricular (LV) filling occurs rapidly early in diastole caused by a progressive pressure gradient within the ventricle and with a low left atrial pressure. This normal diastolic function is altered in patients with heart failure. Such impairment of diastolic filling is manifested as an abrupt deceleration of the early filling wave velocity. Although variations within the early filling wave have been observed previously, the underlying hydrodynamic mechanisms are not well understood. Previously, it was proposed that the mitral annulus vortex ring formation time was the total duration of early diastolic filling and provided a measure of the efficiency of diastolic filling. However, we found that the favorable LV pressure difference driving early diastolic filling becomes zero simultaneously with the deceleration of the early filling wave propagation velocity and pinch-off of the LV vortex ring. Thus we calculated the vortex ring formation time using the duration of the early diastolic filling wave from its initiation to the time of the early filling wave propagation velocity deceleration when pinch-off occurs. This formation time does not vary with decreasing intraventricular pressure difference or with degree of diastolic dysfunction. Thus we conclude the vortex ring pinch-off occurs before the completion of early diastole, and its formation time remains invariant to changes of diastolic function.
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Tasic, Ivan, Dragan Mijalkovic, Dragan Djordjevic, et al. "Effect of fosinopril on progression of the asymptomatic carotid atherosclerosis and left ventricular hypertrophy in hypertensive patients." Srpski arhiv za celokupno lekarstvo 134, no. 3-4 (2006): 106–13. http://dx.doi.org/10.2298/sarh0604106t.
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INTRODUCTION The cardiovascular changes (vascular structure changes, hypertrophy of the left ventricle) contribute to both the increased cardiovascular morbidity and the mortality of essential hypertension. Therefore, modern treatment strategies should not only target blood pressure (BP) reduction but also normalize cardiovascular structure and function. OBJECTIVE Aim of the study was to determine the effect of the ACE inhibitor Fosinopril on the Intima-media thickness of the common carotid artery and on the left ventricle mass after 9-month treatment of hypertensive patients. METHOD The study included 40 patients with the arterial hypertension and the left ventricle hypertrophy verified by echocardiography. The patients were randomized on A) ACE-inhibitor - Fosinopril and 6) without ACE inhibitor - atenolol, and they were followed up 9 months. The groups were not different by age, sex, and metabolic status. Color Duplex ultrasonography of the carotid arteries was performed by Acuson Sequia C236 with high-frequency linear probe of 8 MHz. The Intima-media thickness of the common carotids on the left and the right was measured in diastole at 1.5. cm from the highest point of bifurcation under maximal magnification. Using the same device, the left ventricle mass and other parameters of the left ventricle were determined in M-mode and by means of 2D image. RESULTS After 9 months, BP In both groups Was reduced In similar range (group A: systolic BP from 158 to 137 mmHg, and diastolic BP from 94 to 85 mmHg, and group B; systolic BP from 164 to 137 mmHg, and diastolic BP from 87 to 84 mmHg). The thickness of the intimomedial complex in patients using Fosinopril was decreased by 0.0278 ? 0.03 mm, while in the group of patients that did not use the ACE-inhibitor, it was increased by 0.078 ?0.13 mm. The left ventricle mass in patients using Fosinopril was decreased by 5 grams (312 ? 72 g vs. 307 ? 77 g), while in group B patients, it was increased by 15 grams (323 ? 79 g vs. 328 ? 58 g. Diastolic function expressed through relation E/A was improved minimally in the group A, while it worsened by 0.1 in the group B. After 9 months, serious cardiovascular events were recorded (one infarction of myocardium and one hospitalization due to the unstable angina pectoris) in two patients of the group A, while four patients of the group B. had serious CV events (1 cerebrovascular stroke and 3 hospitalizations due to unstable angina pectoris). CONCLUSION The results of our study showed that the application of Fosinopril in patients with the arterial hypertension and the left ventricle hypertrophy could efficiently block further progression of the intima-medial thickness of the common carotid artery, reduce the left ventricle mass, and improve. diastolic function of the left ventricle.
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Mazur, E. S., V. V. Mazur, Kh A. Djaber, and Yu A. Orlov. "Structural and electrophysiological remodeling interrelation in postinfarction cardiosclerosis and dilated cardiomyopathy." Kazan medical journal 97, no. 2 (2016): 173–77. http://dx.doi.org/10.17750/kmj2016-173.
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Aim. To study the interrelation of ventricles echocardiographic parameters and signal-averaged electrocardiogram indicators in patients with postinfarction cardiosclerosis and dilated cardiomyopathy.Methods. 28 patients with postinfarction cardiosclerosis (men aged 49 to 71 years) and 29 patients with dilated cardiomyopathy (men aged 24 to 61 years) were examined. All patients underwent echocardiography, by which left ventricle final diastolic and systolic volumes with ejection fraction calculation, right ventricle end diastolic and systolic volumes were determined. According to the signal-averaged electrocardiogram, filtered ventricular complex duration, the ventricular complex with an amplitude of less than 40 mV terminal part duration and signal root-mean-square (rms) amplitude of the ventricular complex last 40 ms were evaluated.Results.. According to the correlation analysis, increase in left ventricle end-diastolic and systolic volumes and decrease in its ejection fraction, as well as an increase in right ventricle end-diastolic and systolic volumes were associated with an increase in the filtered ventricular complex duration and the ventricular complex with an amplitude of less than 40 mV terminal part duration in patients with postinfarction cardiosclerosis. The left ventricle volumes increase and ejection fraction reduction were also associated with the signal rms amplitude of the ventricular complex last 40 ms reduction in patients with postinfarction cardiosclerosis. Similar interrelation was not found in patients with dilated cardiomyopathy.Conclusion. In patients with postinfarction cardiosclerosis cavities dilation and reduced systolic ventricular function are accompanied by the myocardium electrophysiological properties deterioration; in patients with dilated cardiomyopathy interrelation between structural and electrophysiological indicators of myocardial remodeling was not found.
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Naumenko, E. P., and I. E. Adzeriho. "DOPPLER TISSUE IMAGING: PRINCIPLES AND POSSIBILITIES OF THE METHOD (literature review)." Health and Ecology Issues, no. 4 (December 28, 2012): 17–22. http://dx.doi.org/10.51523/2708-6011.2012-9-4-3.
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Doppler tissue imaging is a group of regimes based on the Doppler effect and the qualitative and quantitative assessment of the global and segmental myocardial function. Doppler tissue imaging enables to evaluate quantitatively the functional state of not only the left, but also the right ventricle. The using of Doppler tissue imaging is informative for assessing the global and regional function of the left heart ventricle. The Doppler tissue imaging made it possible to assess the systolic and diastolic function of the various segments of the left and right ventricles. The review presents the information about the principles and possibilities of Doppler tissue imaging, the new technology of ultrasound heart examination in assessment of myocardial function. The review also covers the history of myocardial Doppler tissue imaging. The main attention is focused on the characterization of Doppler myocardial tissue imaging regimes.
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YAMAKADO, TETSU, and TAKASHI NAKANO. "Left ventricular systolic and diastolic function in the hypertrophied ventricle." Japanese Circulation Journal 54, no. 5 (1990): 554–62. http://dx.doi.org/10.1253/jcj.54.554.
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Brooks, Paul A., Nee S. Khoo, and Lisa K. Hornberger. "Systolic and Diastolic Function of the Fetal Single Left Ventricle." Journal of the American Society of Echocardiography 27, no. 9 (2014): 972–77. http://dx.doi.org/10.1016/j.echo.2014.06.012.
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Januar, Martha, Soerianata Sunarya, and Soesanto Amiliana. "Left ventricle diastolic function in patients undergoing chemotherapy with doxorubicin." Heart, Lung and Circulation 17 (January 2008): S22. http://dx.doi.org/10.1016/j.hlc.2007.11.056.
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Wikstrand, J. "Diastolic function of the hypertrophied left ventricle in primary hypertension." Clinical Physiology 6, no. 2 (1986): 115–27. http://dx.doi.org/10.1111/j.1475-097x.1986.tb00060.x.
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Karachentsev, A. N., V. G. Kukes, A. S. Kisrieva, and E. A. Mazerkina. "Cardiotropic activity of estrogens during hormone replacement therapy in postmenopausal women." Problems of Endocrinology 46, no. 1 (2000): 16–20. http://dx.doi.org/10.14341/probl11830.
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Cardiotropic activity of estrogens after a single administration and during 12-week substitute hormone therapy was studied during echocardiography and Doppler echocardiography in estrogen deficient women with natural or surgical postmenopause with negative cardiovascular (vasomotor) symptoms with hyperkinetic central hemodynamics, high arterial pressure, and disordered diastolic function of the left ventricle. The results confirm the cardioprotective and positive hemodynamic activity of substitute estrogens. Estrogens improved the initially disturbed diastolic and systolic function of the left ventricle, moderately decreased heart rate and systolic and diastolic arterial pressure. Time course of cardioprotective and hemodynamic effects of substitute monoestrogen therapy and estrogen/gestagen hormone therapy was virtually the same.
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Chávez, Christian Osmar, Osmar Antonio Centurión, Alfredo Javier Meza, et al. "Left Atrial Peak Systolic Strain as an Indicator Pathway of Diastolic Dysfunction of the Left Ventricle." Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine 23, no. 2 (2024): 111–18. http://dx.doi.org/10.1097/hpc.0000000000000349.
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Background: Left atrial peak systolic strain (LA-PSS) imaging is an emerging index of left atrial function, and it was shown to be decreased in heart failure with preserved ejection fraction (EF). We aimed to determine whether LA-PSS could be used as an additional diagnostic parameter to current existing guidelines for the presence of left ventricle diastolic dysfunction (LVDD). Materials and Methods: A total of 190 consecutive adult patients with cardiovascular risk factors and normal left ventricle EF with no prior history of heart failure were included in the study. Speckle tracking software was used to study ventricular parietal deformity, left ventricle global longitudinal systolic strain, and LA-PSS. Results: The median left ventricle global longitudinal systolic strain was −19%, with a significant difference (P < 0.001) between patients with normal diastolic function versus those with LVDD. The median LA-PSS was 33% (30% to 38%) (P < 0.001). Most patients (61%) had grade 1 atrial dysfunction based on PSS (range 24%–35%). The analysis of the area under the receiver operating characteristic curve of the LA-PSS as a potential indicator pathway of LVDD was 67% [95% confidence interval (CI), 62–72], and 75% (95% CI, 70–80), when the indeterminate pattern was included. The decreased LA-PSS made it possible to reclassify patients with an indeterminate pattern of diastolic function in 96% of cases. Conclusions: These results support the potential role of LA-PSS as an additional parameter for the diagnosis of LVDD in patients with normal EF, and may be integrated into the guidelines for routine evaluation of patients.
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Feiskhanova, L. "POS1392 TISSUE DOPPLEROGRAPHY AS A DIAGNOSTIC TOOL FOR MYOCARDIAL DYSFUNCTION IN PATIENTS WITH RHEUMATIC DISEASES." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1036.2–1037. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3755.
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BackgroundPathology of the cardiovascular system has a significant impact on the mortality rate in the population of patients with rheumatic diseases, including rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Involvement of the cardiovascular system determines the course and prognosis of many rheumatic diseases. In the general population, left ventricular diastolic dysfunction is an independent predictor of mortality and symptomatic chronic heart failure. However, routine screening for diastolic dysfunction is rarely performed in patients with RA and AS, especially in those who do not have clinical symptoms.Objectivesto identify early preclinical signs of myocardial dysfunction in patients with RA and AS.Methods142 people with verified rheumatic diseases were examined. All patients were divided into 2 groups. The first group consisted of patients with RA - 95 pts (average age 46.5±11.1 years). The second group consisted of patients with AS, 47 pts (average age 42.3±10.3 years). The control group included 70 healthy individuals (average age 43.7±12.1 years). All patients underwent standard laboratory and instrumental diagnostic tests, which included joint radiography (group 1), magnetic resonance imaging of the spine and ileosacral joints (group 2). In addition, we performed echocardiography and tissue dopplerography of the heart on the GE Vivid E9 ultrasound machine.ResultsThe parameters e’L, e’S, e’R were the lowest in patients with RA (9.95 [8; 12], 8.2 [6; 10], 12 [10; 14], respectively) compared to both the group with AS (11.1 [9; 13.7], 9.8 [7.2; 12], 13.1 [12; 14], respectively), and with the control group (12.1 [10; 14], 9.8 [8; 11], 13.4 [11; 15], respectively) (p<0.005). This indicates a significant deterioration in the diastolic function of both ventricles in patients with RA. We found a similar picture when comparing the systolic velocities of the fibrous ring of the left and right atrioventricular openings S’L, S’S, S’R. In the group of patients with RA, these parameters were the smallest (9.1 [8; 10], 7.4 [7; 8], 12.9 [12; 14], respectively) compared to the other two groups (p<0.0005). These results indicate a significant deterioration in the diastolic and systolic function of both ventricles in patients with RA. Diastolic dysfunction of both the left ventricle (25.3%) and both ventricles (16.8%) was more common among patients with RA compared to the control group (5.7%, 0%, respectively) (p<0.01). The same pattern was found in the group with AS: 17 and 10.6%, respectively (p<0.01). At the same time, there were no statistically significant differences between the 1st and 2nd groups. In addition, the calculation of the relative risk showed that the presence of RA 4.42 times increases the risk of developing diastolic dysfunction of the left ventricle compared with control group (CI 1.6-12.2). It should be noted that in the control group, diastolic dysfunction of the left ventricle was diagnosed only type 1, whereas among people with RA out of 24 pts, 10 had a pseudonormal type, and among patients with AS out of 8 pts, it was detected in four pts.ConclusionPatients with RA and AS are characterized by deterioration of the diastolic function of the left ventricle or both ventricles simultaneously. Quantitative characteristics obtained during tissue dopplerography confirm these changes. In addition, in people with RA, there is also a decrease in the systolic function of both ventricles. Thus, in order to detect early myocardial dysfunction in patients with RA and AS, it is advisable to conduct not only two-dimensional echocardiography, but also tissue dopplerography.References[1]Targońska-Stępniak B., Biskup M., Biskup W. at al. Diastolic dysfunction in rheumatoid arthritis patients with low disease activity. Clin Rheumatol 2019;38(4):1131-7. DOI: 10.1007/s10067-018-4369-7.[2]Heslinga S.C., Van Dongen C.J., Konings T.C. at al. Diastolic left ventricular dysfunction in ankylosing spondylitis – a systematic review and meta-analysis. Semin Arthritis Rheum 2014;44(1):14-9. DOI: 10.1016/j.semarthrit.2014.02.004.Disclosure of InterestsNone declared
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Sindhya, K. S., and Arthi P. S. "Estimation of left ventricular function in chronic alcoholics." International Journal of Advances in Medicine 8, no. 5 (2021): 667. http://dx.doi.org/10.18203/2349-3933.ijam20211473.
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Background: Alcohol abuse is one of the leading causes of millions of deaths, it is also a burden in society. Direct toxicity of ethanol affects cardiac muscle Acute intoxication shows pathological electrocardiogram changes such as sinus tachycardia in alcohol dependence syndrome, sinus arrhythmias, prolongation of QT interval, ventricular polarising complexes, poor progression of R wave, torse de pointes. Changes found in echocardiography are alteration in septal and ventricular wall thickness, left atrial dimensions, left ventricle dimension and mass.Methods: Patients attending outpatient and inpatients section in our tertiary care hospital Shri Balaji Vidhyapeet University were considered in study for a period of two years. Study size was 85 patients, Data were collected regarding proportion of ethanol intake, history of duration, symptoms related to cardiovascular system, blood parameters including thyroid function test, blood sugars are done, body mass index calculated, blood pressure recorded master chart made for statistical verification. The three-dimensional echocardiography in M mode is done by our cardiologist.Results: Echocardiography findings were correlated with duration of intake of alcohol end diastolic volume index (EDVI), End systolic volume index (ESVI), Left ventricle mass index (LVMI) had positive correlation of p-value less than 0.05. when quantity of ethanol intake correlated with echocardiography, Left ventricular inner dimension (LVID), fractional shortening (FS), ejection fraction (EF), posterior wall thickness, E/A ratio has no significance with p value. Abnormality is noted in left ventricle diastolic function and is corresponded to quantity and duration of alcohol. Moderate amount of less than 150grams of ethanol did not showed toxic effects in heart while severe quantity and duration more than ten years of intake showed left ventricle dysfunctionConclusions: Ethanol consumption in massive amount impair cardiac contractile function. Change in left ventricle volume takes place before the defect in the ventricular filling, which would be a marker for effect of ethanol in heart.
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Coelho, Patrícia, Hugo Duarte, Carlos Alcafache, and Francisco Rodrigues. "The Influence of Pericardial Fat on Left Ventricular Diastolic Function." Diagnostics 14, no. 7 (2024): 702. http://dx.doi.org/10.3390/diagnostics14070702.
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Background: Heart failure is a major cause of morbidity and mortality worldwide; left ventricular diastolic dysfunction plays a leading role in this clinical context. Diastolic dysfunction may be predisposed by increased abdominal fat and, consequently, increased pericardial and epicardial adiposity. This study aimed to determine whether pericardial fat (PF) and epicardial fat (EF) are associated with left ventricular diastolic function. Methods: A total of 82 patients had their abdominal circumference measured and underwent transthoracic echocardiography to measure the thickness of PF and EF and assess the left ventricular diastolic function. Two groups were created based on mean pericardial fat (PF) thickness (4.644 mm) and were related to abdominal circumference and echocardiographic parameters. Results: Subjects in the PF High group showed a significant decrease in septal e’ (p < 0.0001), lateral e’ (p < 0.0001), and E/A ratio (p = 0.003), as well as a significant increase in E/e’ ratio (p < 0.0001), E wave deceleration time (p = 0.013), left atrial volume (p < 0.0001), the left ventricle mass (p = 0.003), tricuspid regurgitant jet velocity (p < 0.0001), and the left ventricle diameter (p = 0.014) compared to the PF Low group. Correlations were found between pericardial fat and nine echocardiographic parameters in the study, while epicardial fat (EP) only correlated with eight. Conclusions: Measurement of abdominal circumference, PF, and EF is an early indicator of diastolic changes with transthoracic echocardiography being the gold standard exam.
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Korotenko, Olga Yu, Egor S. Filimonov, Nikolay I. Panev, and Evgeniya V. Ulanova. "Diastolic function of the right ventricle in workers of coal mining enterprises in the South of Kuzbass." Russian Journal of Occupational Health and Industrial Ecology 61, no. 6 (2021): 371–78. http://dx.doi.org/10.31089/1026-9428-2021-61-6-371-378.
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Introduction. Diastolic function is characterized by the earliest changes in the ventricular myocardium, rather than violations of their contractility, and can be used in the algorithm of prophylactic measures to prevent fatal cardiovascular events, including in people working at industrial enterprises. The objective of the study was to assess the indices of diastolic function of the right ventricle in workers of the coal mining industry in the South of Kuzbass. Materials and methods. Under the conditions of a periodic medical examination, we surveyed 337 people without lung diseases and coronary heart disease, of which 206 workers of coal mines in the South of Kuzbass and 131 workers of open pit mines, aged from 40 to 55 years (the average age of the miners was 46.12±0.36 years old, of the workers at open pit mines was 46.98±0.34 years, p=0.107). On the ultrasound system "Vivid E9" manufactured by General Electric, all examined persons underwent an assessment of the structural and functional state of the heart. Results. Diastolic dysfunction in the form of a decrease in the ratio of transtricuspid flows less than one was revealed in 22.5% of the miners with arterial hypertension and in 2.6% of the subjects without it (p=0.00001), in the workers of open pit mines there was in 12.3% and 8.3%, respectively (p=0.071). A decrease in the ratio of tissue Doppler flows of tricuspid annulus plane movement was detected in 89.9% of the miners with arterial hypertension and in 81.2% of the subjects without it (p=0.083), this parameter also did not differ among the workers of open pit mines (68.4% and 60.3% respectively, p=0.337), but the differences between the miners and the workers of the open pit mines turned out to be reliable (p=0.0012 in those examined with arterial hypertension, p=0.0015 - without it). Based on the conducted correlation analysis, it was revealed that the development of impaired right ventricular diastolic function in coal industry workers was influenced not only by generally accepted factors and concomitant arterial hypertension, but also by long-term work experience in underground conditions in the miners. Conclusion. The development of diastolic dysfunction of the right ventricle in miners was influenced by work experience in underground working conditions, the presence of arterial hypertension, a decrease in the longitudinal deformation of the left ventricle, a decline in the vital capacity of the lungs and impaired diastolic function of the left ventricle. Associations of right ventricular diastolic function indices with the presence of arterial hypertension, increased values of the smoker’s index, Quetelet index, waist circumference, relative wall thickness index of the left ventricle, a decrease in the longitudinal deformation of the left ventricle and forced expiratory volume in 1 second and impaired diastolic function of the left ventricle were revealed in the workers of open pit mines.