Relevant bibliographies by topics / Diazepam

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Diazepam'

Author: Grafiati
Published: 4 June 2021
Last updated: 11 June 2025

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Journal articles on the topic "Diazepam"

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Hadžiabdić, Jasmina, Nevenka Kopjar, Davor Želježić, Selma Špirtović-Halilović та Davorka Završnik. "Cytogenotoxicity of Inclusion Complexes of Diazepam with 2-Hydroxypropyl-β-cyclodextrin". Drug Research 67, № 11 (2017): 661–72. http://dx.doi.org/10.1055/s-0043-115123.

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Abstract Background Diazepam, as one of the most frequent prescribed drug from 1,4-benzodiazepine group, has certain limitations in pharmaceutical technology due to its poor solubility in water. By forming inclusion complexes with 2-hydroxypropyl-β-cyclodextrin, diazepam's biopharmaceutical properties can be greatly improved. Aim Aim of this research was to in vitro evaluate genotoxicity of prepared novel complexes of diazepam and their influence on proliferation of human peripheral blood lymphocytes. Methods For identification of possible genotoxicity of diazepam inclusion complexes, cytokinesis-block micronucleus assay has been chosen. Evaluated concentrations of two diazepam inclusion complexes were 0.2 µg/mL, 0.5 µg/mL and 1.0 µg/mL in cell culture. For a reference, in vitro cytogenotoxicity evaluation of diazepam alone has been conducted as well. Results Neither one of the diazepam, complexed nor non-complexed, in given concentrations showed genotoxicity, induced genetic damage or loss of genetic material. Conclusions Nuclear division index values, as indicators of cytostaticity and cytotoxicity suggested that investigated inclusion diazepam complexes induced accelerated proliferation of human peripheral blood lymphocytes in vitro, therefore possibly shortening the duration and dynamics of the cell cycle.
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&NA;. "Diazepam." Reactions Weekly &NA;, no. 759 (1999): 7. http://dx.doi.org/10.2165/00128415-199907590-00019.

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&NA;. "Diazepam." Reactions Weekly &NA;, no. 424 (1992): 8. http://dx.doi.org/10.2165/00128415-199204240-00034.

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&NA;. "Diazepam." Reactions Weekly &NA;, no. 432 (1992): 9. http://dx.doi.org/10.2165/00128415-199204320-00044.

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&NA;. "Diazepam." Reactions Weekly &NA;, no. 462 (1993): 7. http://dx.doi.org/10.2165/00128415-199304620-00033.

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&NA;. "Diazepam." Reactions Weekly &NA;, no. 770 (1999): 6. http://dx.doi.org/10.2165/00128415-199907700-00019.

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&NA;. "Diazepam." Reactions Weekly &NA;, no. 367 (1991): 6–7. http://dx.doi.org/10.2165/00128415-199103670-00023.

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&NA;. "Diazepam." Reactions Weekly &NA;, no. 389 (1992): 8. http://dx.doi.org/10.2165/00128415-199203890-00029.

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&NA;. "Diazepam." Reactions Weekly &NA;, no. 394 (1992): 6. http://dx.doi.org/10.2165/00128415-199203940-00015.

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&NA;. "Diazepam." Reactions Weekly &NA;, no. 400 (1992): 7. http://dx.doi.org/10.2165/00128415-199204000-00028.

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Dissertations / Theses on the topic "Diazepam"

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Silva, Sílvia Raquel Filipe da. "Farmacocinética do diazepam." Master's thesis, [s.n.], 2013. http://hdl.handle.net/10284/3978.

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Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas<br>O diazepam é um princípio ativo do grupo farmacológico das benzodiapezinas, do qual é o mais representativo, sendo por muitos considerado a molécula modelo deste grupo. É largamente utilizado no tratamento de ansiedades e outros distúrbios físicos e psicológicos associados às mesmas. De forma a optimizar os resultados da prática clínica, considerando o factor variabilidade interindividual, é essencial recorrer à monitorização terapêutica e ao estudo da evolução temporal das concentrações por meio de simulações farmacocinéticas. A farmacocinética do diazepam vem sendo estudada desde os anos setenta do século XX e tem sido modelada por recurso a vários tipos de modelos farmacocinéticos, nomeadamente, compartimentais (de um, dois ou mais compartimentos) e de base fisiológica, limitados por perfusão ou por difusão, envolvendo diferentes níveis de complexidade, nomeadamente no que toca ao número de órgãos considerados. No que concerne aos modelos compartimentais, grandes avanços foram conseguidos quando a conversão do diazepam nos seus metabolitos (N-desmetildiazepam, temazepam e oxazepam) foi considerada. Todavia, atualmente os modelos de base fisiológica são aqueles que têm merecido mais atenção por parte da comunidade científica. Nesta tese é apresentada uma revisão bibliográfica organizada em perspectiva histórica de como a farmacocinética do diazepam tem vindo a ser estudada. As referências foram selecionadas e analisadas segundo a informação cinética ou dinâmica que fornecem, de modo a expor os diferentes modelos farmacocinéticos que têm sido propostos, bem como elucidar a sua aplicação. Adicionalmente e a título exemplificativo, apresenta-se uma simulação de um dos modelos farmacocinéticos de base fisiológica mais citados, de Igari et al. (1983), usando o Microsoft Excel®. Os resultados desta simulação quando se utiliza o método de Euler para integrar o sistema de equações diferenciais apresentam uma razoável concordância com as curvas de concentração experimentais para os diferentes órgãos. Diazepam is the most representative drug of the pharmacological group of benzodiazepines, being considered by many as a model molecule of this group. It is widely used in the treatment of anxiety and other physical and psychological disorders associated therewith. In order to optimize the results of clinical practice, in particular to take into account the intersubject variability, it is essential to implement therapeutic monitoring, to study the time evolution of concentrations and to recourse to pharmacokinetic simulation. The pharmacokinetics of diazepam has been studied since the early seventies of the past century and has been modeled by use of various pharmacokinetic models, including compartmental (of one, two or more compartments) and physiologically based, limited by diffusion or by perfusion, and with different levels of complexity , particularly with regard to the number of organs considered. In what concerns the compartmental models, major advances were achieved when the conversion of the diazepam into its metabolites (N-desmetildiazepam, temazepam and oxazepam) was considered. Yet, currently the physiologic models are those who have received more attention from the scientific community. This thesis presents a literature review, organized in historical perspective, of how the pharmacokinetics of diazepam has been studied. References were selected and analyzed according to the dynamic or kinetic information they provide, in order to expose the different pharmacokinetic models that have been proposed, and to clarify their application. Additionally and as an example, it is presented a simulation of one of the most cited a physiologically based pharmacokinetic model using Microsoft Excel® and experimental data of Igari et al. (1983). The results of simulation when using the Euler method to integrate the system of differential equations have a reasonable agreement with the experimental diazepam concentration profiles for the different organs.
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Aerden, Leo Adrianus Maria. "Diazepam in acute stroke /." [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Universiteit Maastricht [host], 2006. http://arno.unimaas.nl/show.cgi?fid=5836.

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Barbour, Carol J. "Analytical studies on diazepam." Thesis, University of Strathclyde, 1987. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=21481.

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Assay methods have been developed which are specific for the analysis of diazepam in the presence of formulation excipients, closely related degradation products and manufacturing impurities. The methods developed used difference ultraviolet spectrophotometry and HPLC. These methods have been applied to the analysis of diazepam in formulations and to investigate the reaction kinetics of the acid hydrolysis of diazepam. From analysis of both fresh and stored samples of formulations, it was seen that solid dosage forms showed no degradation, but degradation products were detected in liquid formulations. Advantages and disadvantages were seen for both techniques and criteria were established for the choice of method. The reaction kinetics of the degradation of diazepam was studied, using HPLC and GC. Previous workers had investigated the acid hydrolysis of diazepam using non-specific analytical methods. An attempt was made to repeat their work using the specific chromatographic methods described. From initial work, it appears that the results obtained are similar to those previously generated. Further work is required to investigate this more fully.
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Rocha, Vanessa de Moraes. "Efeito do esteroide anabolico nandrolona sobre o nivel de ansidade em ratos." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/288845.

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Orientador: Fernanda Klein Marcondes<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-08T02:16:22Z (GMT). No. of bitstreams: 1 Rocha_VanessadeMoraes_M.pdf: 1061559 bytes, checksum: 4455455a00850fa30a24f9a89ea8dd5e (MD5) Previous issue date: 2006<br>Resumo: Os esteróides androgênicos anabólicos (EAA) são usados no tratamento de hipogonadismo masculino, andropausa associada ao envelhecimento, osteoporose, anemia associada à doença renal crônica, síndrome de imunodeficiência adquirida, politraumatismo e em períodos pós-operatórios. Porém, o uso de EAA, com finalidades não¿terapêuticas, e em altas doses, apresenta graves efeitos colaterais que incluem alterações de humor, agressividade e aumento da incidência de suicídios. O objetivo deste estudo foi avaliar o efeito do decanoato de nandrolona sobre o nível de ansiedade de ratos. Ratos machos Wistar, com 2 meses de idade foram aleatoriamente divididos em 6 grupos (n = 12- 15/grupo): controle, veículo, nandrolona, controle + diazepam, veículo + diazepam e nandrolona + diazepam. Animais tratados com veículo ou nandrolona receberam administração de propilenoglicol (0,2 mL/ Kg i.m.)ou decanoato de nandrolona (5mg/Kg i.m.), respectivamente, 2 vezes por semana, durante 6 semanas. Ratos do grupo controle foram submetidos somente aos procedimentos relacionados à rotina do biotério. No fim de 6 semanas, todos os grupos foram submetidos ao teste do LCE, 24 h após a última administração de veículo ou nandrolona, ou período equivalente para o grupo controle. Para validação farmacológica dos resultados comportamentais, alguns animais foram tratados com diazepam (1mg/Kg i.p.), 30 min antes do teste comportamental. Os resultados foram comparados por análise de variância, e teste de Tukey (p<0,05). Animais tratados com o nandrolona apresentaram menor porcentagem de tempo nos braços abertos (1,46 ± 0,90) quando comparados àqueles tratados com veículo (3,96 ± 0,85) e controles (3,80 ± 0,97 %). O grupo tratado com nandrolona também apresentou menor porcentagem de entradas nos braços abertos (6,00 ± 1,67) em relação aos grupos veículo (15,06 ± 2,80) e controle (16,75 ± 3,30 %). Contudo, a nandrolona não promoveu alteração no número de entradas nos braços fechados, na avaliação de risco e no número de idas ao final dos braços abertos. O tratamento com diazepam reverteu os efeitos causados pela nandrolona na porcentagem de tempo e no número de entradas nos braços abertos. Estes dados sugerem que o decanoato de nandrolona induziu aumento no nível de ansiedade em ratos de laboratório<br>Abstract: Androgenic anabolic steroids (AAS) are used for the treatment of male hypogonadism, andropause associated with elderly, osteoporosis, anemia associated with kidney failure, acquired immunodeficiency disease syndrome, politraumatism and postsurgery periods. However, the AAS abuse and non-therapeutic use, in higher doses show side effects, including mood alteractions, aggressiveness and higher suicide incidence. The aim of this study was to evaluate the nandrolone decanoate effect on the anxiety levels in rats. Male Wistar rats (2 mo.) were randomly divided into 6 groups (n = 12-15/groups: control, vehicle, nandrolone, control + diazepam, vehicle + diazepam, and nandrolone + diazepam. The vehicle or nandrolone treated animals received injection of propilenglycol (0,2mL/Kg, i.m.) or nandrolone decanoate (0,5 mg/Kg i.m.), respectively, twice a week, for 6 weeks. Control group rats were subject only to procedures related to their routine living conditions. By the end of 6 weeks, all groups were submitted to the elevated pluz maze (EPM), 24 hours after the last vehicle or nandrolone injection, or equivalent period for the control group. In order to pharmacological validation, some animals were treated with diazepam (1 mg/Kg i.p.) 30 min before the EPM. Data were analyzed by Two-way ANOVA and post-hoc Tukey test (p<0,05). Nandrolone treated animals showed less percentage of time spent in the open arms (1.46 ± 0.49) compared with control (3.80 ± 0.97) and vehicle (3.96 ± 0.85 %) groups. Nandrolone treated animals also showed less percentage of open arms entries (6,00 ± 1,67) in relation to vehicles groups (15,06 ± 2,80) and control groups (16,75 ± 3,30 %). However, nandrolone did not promote any changes in enclosed arms entries, risk assessment and final open arms end- exploring. Diazepam treatment reverted the effects of nandrolone in the time and entries percentage in the open arms. The present data showed that the treatment with a high dose of nandrolone decanoate induced an increase in the anxiety level in rats<br>Mestrado<br>Fisiologia Oral<br>Mestre em Odontologia
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Nicholson, Martin William. "Diazepam-dependent modulation of GABAergic inhibitory synapses." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10046265/.

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Diazepam is an allosteric modulator of GABAA receptors which potentiates GABAA receptor activity resulting in enhanced inhibitory synaptic transmission. Diazepam is used to treat anxiety, insomnia and seizures, however, its use is limited due to the development of tolerance. Here I show that prolonged treatment of cortical neurones with diazepam triggers endocytosis and subsequent downregulation of cell-surface GABAA receptors. Using pharmacological reagents, I have demonstrated that diazepam triggers PLC-dependent release of calcium from the endoplasmic reticulum which activates the phosphatase calcineurin resulting in dephosphorylation of the γ2 subunit of GABAA receptors and their endocytosis. This was elucidated using a combination of biochemical and cell biological approaches. In addition, I have developed HEK293 cell lines stably expressing various subtypes of GABAA receptors to investigate further diazepam and isoguvacine-dependent regulation of GABAA receptors. The same calcium-dependent signalling pathway that regulates cell-surface stability of GABAA receptors in neurones was found to operate in HEK293 cells. Subsequently, I focused on a key component of this signalling pathway; PLCδ1. Using biochemical techniques I have demonstrated that PLCδ1 binds directly to the GABAA receptor β3 subunit at two independent sites. This binding was confirmed by coimmunoprecipitation of PLCδ1 and GABAA receptors from cortical neuronal lysates. Interestingly, upon diazepam treatments, PLCδ1 was shown to dissociate from GABAA receptors, thus leading to mobilisation of calcium from the intracellular stores and activation of calcineurin. To assess how changes in cell-surface expression of GABAA receptors affect the stability of GABAergic synapses, I characterised the size and number of post-synaptic GABAA receptor clusters and the number of presynaptic GABA-releasing terminals following chronic diazepam treatment. I observed a reduction in the size and number of post-synaptic GABAA receptor clusters and a reduction in the number of GABA-releasing terminals. These data are consistent with the loss of cell-surface GABAA receptors following long-term treatments of cortical neurones with diazepam. These changes correlated with an increase in the expression of the early apoptosis marker, cleaved-caspase 3, in glutamatergic neurones suggesting indirect cytotoxic effects of diazepam treatments. The loss of inhibitory GABAergic synapses following chronic diazepam treatment may contribute to the well-known development of tolerance to these clinically important therapies for stress- and anxiety- related neurological disorders.
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Janušauskaitė, Gineta. "Diazepamo, metamizolo natrio ir omeprazolo mišinio tyrimas instrumentinės analizės metodais." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140618_215801-90728.

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Šio darbo tikslas buvo pritaikyti instrumentinės analizės metodus (plonasluoksnės chromatografijos, UV - spektroskopijos ir efektyviosios skysčių chromatografijos) apsinuodijimą sukeliančio mišinio - diazepamo, metamizolo natrio druskos ir omeprazolo tyrimui. UV spektroskopijos metodas tinkamas atskirų mišinį sudarančių komponentų omeprazolo, diazepamo, metamizolo natrio identifikavimui. Plonasluoksnės chromatografijos metodas buvo pritaikytas metodikos kūrime tirtų medžiagų mišinio identifikavimui ir atskyrimui suradus ir modifikavus dvi tirpiklių sistemas: etilacetatas : etanolis: 25% NH4OH santykiu 17:2:1; etilacetatas : etanolis : 25% NH4OH : benzenas santykiu 16:3:1:4. Sukurta metodika tinkanti omeprazolo, metamizolo natrio ir diazepamo atskyrimui ir identifikavimui efektyviosios skysčių chromatografijos metodu.<br>This work was undertaken to instrumental analytical methods (thin-layer chromatography, UV - spectroscopy and high performance liquid chromatography) poisoning causes mix - diazepam, metamizol sodium and omeprazole test. UV – spectroscopy method is suitable individual components fixing of the latter.The thin-layer chromatographic method has been applied to investigate the creation of methods for identification and mixture separation and finding a modification of the two solvent systems: ethyl acetate: ethanol: 25% NH4OH 17:2:1 ratio; ethyl acetate: ethanol: 25% NH4OH: benzene ratio of 16: 3:1:4. Also was created solvent system suitable for omeprazole, metamizol sodium and diazepam separation and identification using high-performance liquid chromatography.
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Paula, Valéria Veras De. "Efeito da pré-medicação em papagaios (Amazona aestiva), com cloridrato de cetamina isolado ou associado ao diazepam, sobre a indução e anestesia com sevofluorano." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/10/10137/tde-09042007-183459/.

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A pré-medicação apesar de ser freqüentemente utilizada nos mamíferos, é raramente utilizada nas espécies aviárias. O objetivo deste estudo foi avaliar o efeito da pré-medicação na indução e anestesia com sevofluorano em papagaios. Foram utilizados trinta e seis animais adultos oriundos do Parque ecológico do Tietê. Os animais foram randomicamente distribuídos em três grupos: grupo I (n = 12), tratado com NaCl 0,9% como placebo, grupo II (n = 12), com cetamina 10 mg.Kg-1 e grupo III (n = 12), com cetamina 10 mg.Kg-1 e diazepam 0,5 mg.Kg-1, por via intramuscular. Quinze minutos após a pré-medicação, a indução foi realizada por meio de máscara facial conectada a um circuito sem reinalação, usando 4,5% de sevofluorano em 100% de oxigênio, com um fluxo de 1,5L. Tanto os efeitos cardiovasculares e respiratórios, bem como, a qualidade da pré-medicação, indução e recuperação da anestesia foram avaliadas. A Dose anestésica mínima obtida neste estudo foi de 2.4 &plusmn; 0.37%, 1.7 &plusmn; 0.39%, e 1.3 &plusmn; 0.32% para os grupos I, II e III respectivamente. Foi concluído que a cetamina isolada ou cetamina/diazepam diminuem consideravelmente a dose anestésica mínima em papagaios. A cetamina isolada ou em associação, promoveu uma boa qualidade de sedação, permitindo uma melhor indução da anestesia quando comparada a indução com o agente inalatório. Tanto a cetamina isolada quanto a associação, mostraram-se seguras, não alterando as funções cardiovasculares, a oxigenação ou ventilação, podendo ser utilizados com sucesso nesta espécie. Além disto, a anestesia com o sevofluorano foi considerada segura para esta espécie em todos os protocolos estudados.<br>Although pre-medication is commonly used in mammals, it is rarely used in avian species. The aim of this study was to evaluate the effect of pre-medication in the induction and anesthesia with sevoflurane in parrots. Thirty-six adults animals were utilized from Tietê ecologic park. The animals were randomically distributed in three groups: group I (n = 12), was pre-medicated with NaCl0.9% as a placebo, group II (n = 12), with ketamine 10 mg.kg-1 and group III (n = 12), with ketamine 10mg.kg-1 and diazepam 0.5mg.kg-1, intramuscularly. Fifteen minutes after pre-medication, the induction was accomplished with a facial mask connected to a non rebreathing circuit using 4.5% of sevoflurane in 100% oxygen with a flow rate of 1.5L. The cardiovascular and respiratory effects were evaluated as well as the quality of pre-medication, induction and recovery of anesthesia. The minimal anesthetic concentration obtained at this study was 2.4 &plusmn; 0.37%, 1.7 &plusmn; 0.39%, and 1.3 &plusmn; 0.32% for group I, II and III respectively. It was concluded that ketamine alone or ketamine/diazepam consider decreased the DAM of sevofluorano in parrots. ketamine alone or in association, promoted a good quality of sedation allowing better induction of anesthesia when compared with the induction with inhalant agent. Even ketamine alone or the association were considered a safe procedure, not changing cardiovascular, oxygenation and ventilation and could be successfully used in this specie. Furthermore, the anesthesia with sevoflurane was considered safe to this specie in all protocols.
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Battrum-Mounts, Deborah E. "A comparison of two conventional sedatives-diazepam and droperidol in combination with fentanyl in surgical patients." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/24474.

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One hundred patients who were to have cataract extraction and intraocular lens replacement carried out were randomly assigned to one of two drug groups. The purpose was to compare droperidol/ fentanyl and diazepam/fentanyl for the following effects: central nervous system depression, cardiovascular depression and ability to alleviate anxiety. Patients, psychology observes, and surgeons were not cognizant of others' opionons, nor of assignment of drug treatment group. Experimental design was a between group single treatment design. Psychological testing consisted of State-Trait Anxiety Inventory of Spielberger, Gorsuch and Lushene, and the Sensory/Affect ratio pain descriptors of Gracely, Dubner and McGrath. Opinion of ease of carrying out the surgical procedure was obtained from the surgeon, and opinion of the anaesthetic outcome was obtained from the anaesthetist. While both drug combinations proved to be successful for use as a sedative adjunct to local anaesthetic for this type of surgical procedure some differences were found. Patients found the diazepam/ fentanyl combination provided for a less intense overall procedure, and had little if any recall of the procedure. The surgeons also found the patients less restless in the diazepam/fentanyl group. Anaesthetists rated the level of sedation as equivalent for both groups and found there was not a significant difference between the amount of sedation they observed.<br>Dentistry, Faculty of<br>Graduate
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Gomes, Sandra Terezinha Marques. "Desenvolvimento de um eletrodo de pasta de carbono modificado para acumulação e determinação voltametrica de diazepan." [s.n.], 1997. http://repositorio.unicamp.br/jspui/handle/REPOSIP/248498.

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Orientadores: Luiz Manoel Aleixo, Oswaldo E. S. Godinho<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Quimica<br>Made available in DSpace on 2018-07-23T06:59:49Z (GMT). No. of bitstreams: 1 Gomes_SandraTerezinhaMarques_D.pdf: 3400371 bytes, checksum: f579f07964f5142b6020fa1c3dd23fc8 (MD5) Previous issue date: 1997<br>Doutorado
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Reid, Lee. "What role does the α1-GABA←A receptor subtype play in mediating the development of tolerance, dependence, and sensitisation following long-term exposure to benzodiazepines?" Thesis, University of Sussex, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250006.

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Books on the topic "Diazepam"

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Diazepam: [riwāyah]. Dār al-Ḥiwār, 2001.

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Reiter, Susanne. Digoxinspiegelveränderungen nach einmaliger Diazepam-Gabe. [s.n.], 1985.

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Rauh, Hans Werner. Dikaliumclorazepat und Diazepam bei Niereninsuffizienz, Serumkonzentrationen und Proteinbindung von Diazepam und Desmethyldiazepam: Gleichzeitig ein Beitrag zur Pharmakologie der Benzodiazepine. [s.n.], 1985.

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Winger, Gail. Valium and other tranquilizers. Chelsea House Publishers, 1992.

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Beischlag, Timothy V. P. C. The effect of mephenytoin on diazepam metabolism in rat and man. National Library of Canada, 1990.

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Joint Epilepsy Council of the UK and Ireland. A guideline on training standards for the administration of rectal diazepam. Joint Epilepsy Council of the UK and Ireland, 2000.

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Parker, Philip M., and James N. Parker. Diazepam: A medical dictionary, bibliography, and annotated research guide to Internet references. ICON Health Publications, 2003.

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Zomorodi, Katayoun. The interaction between omeprazole and diazepam: Investigations performed in various drugmetabolising systems. University of Manchester, 1994.

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Barbara, Gordon. I'm dancing as fast as I can. 3rd ed. Beaufort Books, 2011.

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Alison, Smiley, Moskowitz Herbert K, Ziedman Kenneth, and United States. Alcohol, Drug Abuse, and Mental Health Administration., eds. Effects of drugs on driving: Driving simulator tests of secobarbital, diazepam, marijuana, and alcohol. For sale by the Supt. of Docs., U.S. G.P.O., 1985.

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Book chapters on the topic "Diazepam"

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Benkert, Otto, Ion Anghelescu, Christoph Fehr, et al. "Diazepam." In Pocket Guide Psychopharmaka von A bis Z. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-01910-4_31.

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Courtney, John C. "Diazepam." In Encyclopedia of Clinical Neuropsychology. Springer New York, 2011. http://dx.doi.org/10.1007/978-0-387-79948-3_1649.

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Beyer, Karl-Heinz. "Diazepam." In Biotransformation der Arzneimittel. Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-74386-3_103.

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Courtney, John C., and Efrain Antonio Gonzalez. "Diazepam." In Encyclopedia of Clinical Neuropsychology. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-56782-2_1649-2.

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Gonzalez, Efrain Antonio. "Diazepam." In Encyclopedia of Clinical Neuropsychology. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-56782-2_1649-3.

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Gonzalez, Efrain Antonio. "Diazepam." In Encyclopedia of Clinical Neuropsychology. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-57111-9_1649.

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Simola, Nicola, Micaela Morelli, Tooru Mizuno, et al. "Diazepam." In Encyclopedia of Psychopharmacology. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_1732.

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Balogh, Nicholas J. "Diazepam." In Encyclopedia of Child Behavior and Development. Springer US, 2011. http://dx.doi.org/10.1007/978-0-387-79061-9_3001.

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Stabel, Aaron, Kimberly Kroeger-Geoppinger, Jennifer McCullagh, et al. "Diazepam." In Encyclopedia of Autism Spectrum Disorders. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1698-3_1434.

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Goodkin, Howard P. "Diazepam." In Atlas of Epilepsies. Springer London, 2010. http://dx.doi.org/10.1007/978-1-84882-128-6_263.

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Conference papers on the topic "Diazepam"

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COLPINI, L. M. S., G. N. SILVA, L. E. N. CASTRO, et al. "DEGRADAÇÃO DO DIAZEPAM POR FOTOCATÁLISE HETEROGÊNEA." In XXII Congresso Brasileiro de Engenharia Química. Editora Blucher, 2018. http://dx.doi.org/10.5151/cobeq2018-pt.0971.

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Aguiar, Beatriz Rosa de Oliveira, and SHARLENE LOPES PEREIRA. "INTERAÇÕES ALIMENTARES ESTÃO ADEQUADAMENTE DESCRITAS NAS BULAS DO DIAZEPAM?" In I Congresso Nacional de Saúde Coletiva On-line. Revista Multidisciplinar em Saúde, 2023. http://dx.doi.org/10.51161/conasc/21755.

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Okkesim, Cukru, Musa Hakan Asyali, Sadik Kara, and Mehmet Gungor Kaya. "Effect of diazepam on the sempatovagal balance and O2 saturation." In 2010 15th National Biomedical Engineering Meeting (BIYOMUT 2010). IEEE, 2010. http://dx.doi.org/10.1109/biyomut.2010.5479858.

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Barbosa, R., A. Capela, C. Sampaio, et al. "3PC-028 Compounding an oral liquid formulation of diazepam alcohol free." In 25th EAHP Congress, 25th–27th March 2020, Gothenburg, Sweden. British Medical Journal Publishing Group, 2020. http://dx.doi.org/10.1136/ejhpharm-2020-eahpconf.75.

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Schürfeld, Robin, Benjamin Sandner, Annett Hoffmann, et al. "Renal function is a major predictor of circulating acyl-CoA-binding protein/diazepam-binding inhibitor." In Diabetes Kongress 2023 - 57. Jahrestagung der DDG. Georg Thieme Verlag, 2023. http://dx.doi.org/10.1055/s-0043-1767932.

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Damasceno Júnior, Eustáquio Costa, Isabella Sabião Borges, João Victor Aguiar Moreira, et al. "Successful treatment with rituximab in a refractory Stiffperson syndrome (SPS)." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.507.

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Background: SPS is a disorder consisting of rigidity of axial muscles with painful spasms. More than 80 % of SPS patients have high titer antibodies against glutamic acid decarboxylase (GAD). The use of rituximab for the treatment of SPS is a recent therapeutical approach showing promising results. We present a case of SPS treated with rituximab, showing a good and safe response. Case: A 38-year-old female patient presented with a history of rigidity of abdominal and paravertebral muscles associated with painful spasms in lower back region, increased tonus, lumbar lordosis, frequent falls and severe functional limitation. The anti-GAD antibodies were positive in high titles. Electromyography showed continuous motor activity with normal morphology especially on paravertebral muscles. She had a partial response to baclofen and diazepam, but could not tolerate it because of somnolence, and started the treatment with rituximab. After one year, the baclofen was discontinued and the diazepam reduced. The axial stiffness and spasm frequency improved, including postural instability, without new episodes of falls. Discussion: Rituximab is a monoclonal antibody targeting the CD20 antigens on the surface of mature B lymphocytes. After binding to these antigens, it initiates a cascade of biochemical events leading to apoptosis. Its use has been approved for numerous diseases with promising results. The use of rituximab in the treatment of SPS is a recent approach and good results have been reported. Conclusion: Rituximab may be a promising option in SPS treatment. However, this is a preliminary paper showing partial results requiring long-term follow-up.
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"PV-004 - THE COMPLEXITY OF DUAL PATHOLOGY: REGARDING A CASE REPORT OF SEIZURES." In 24 CONGRESO DE LA SOCIEDAD ESPAÑOLA DE PATOLOGÍA DUAL. SEPD, 2022. http://dx.doi.org/10.17579/abstractbooksepd2022.pv004.

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Objectives: Wernicke's encephalopathy (WE) is a potentially reversible neuropsychiatric emergency caused by thiamine deficiency, whose classical triad consists of confusion, ataxia, and oculomotor dysfunction. The diagnosis is missed in 75-80% of cases and approximately 80% of untreated patients develop Korsakoff Syndrome, whereby recognition of nutritional deficiency or any portion of the triad should prompt treatment. We present a case of a 44-year-old Ukrainian man with suspected background of chronic alcohol abuse and psychiatric history of schizoaffective disorder, who presented with acute onset of confusion, psychomotor agitation, gait ataxia and nystagmus. Anamnesis was hampered by the language barrier and absence of past medical history and patient's alcoholic habits remained unclear. After suspicion of WE it was introduced thiamine and diazepam, with significant improvement. After discontinuation of diazepam, the patient presented with several episodes of tonic-clonic seizures. Starting from this case report, we pretend to discuss the differential diagnosis of seizures in dual pathology. Materials and methods: Clinical records and Pubmed search using the keywords: Wernicke’s Encephalopathy, Seizures, Alcohol, Benzodiazepines. Results and conclusions: Seizures are a common presentation of various conditions associated with alcohol use, whose differential diagnosis is difficult, especially in patients with dubious alcohol consumption. Alcohol abuse is a major precipitant of status epilepticus as seizure threshold is raised by alcohol drinking. Seizures may also occur during alcohol withdrawal for which treatment with benzodiazepines is recommended, however carefully, since both abrupt cessation and high-dose use are critical for the appearance of seizures. Although very rare, WE may also present with seizures, whereby overdiagnosis and overtreatment are preferred to prevent persistent neurocognitive impairments. At discharge the diagnostic discussion prevailed and the patient was medicated for seizures with clinical stabilization. The complexity of psychiatric diagnoses in dual pathology requires a longitudinal assessment for a better understanding of clinical conditions as illustrated here.
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"Comparison of the anesthesia with concurrent use of Mentha piperita essential oil-ketamine with diazepam-ketamine in male rat." In International Conference on Medicine, Public Health and Biological Sciences. CASRP Publishing Company, Ltd. Uk, 2016. http://dx.doi.org/10.18869/mphbs.2016.224.

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Huergo Lora, Covadonga, Sergio Ocio León, Manuel Gómez Simón, et al. "PATOLOGÍA DUAL Y COMORBILIDAD SOMÁTICA. CASO CLÍNICO." In 22° Congreso de la Sociedad Española de Patología Dual (SEPD) 2020. SEPD, 2020. http://dx.doi.org/10.17579/sepd2020p111.

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Se expone el caso clínico de patología dual acompañado de comorbilidad somática: mujer de 52 años conocida tanto en seguimiento en UTT Mieres como por múltiples ingresos en la unidad de hospitalización debido a historia de consumo perjudicial de alcohol ( abstinente en la actualidad a dicho tóxico), síndrome de dependencia a opioides en actualidad en abstinencia en régimen clínico de mantenimiento o sustitución supervisado y trastorno de inestabilidad emocional con el siguiente tratamiento psicofarmacológico: trazodona 100 mg, buprenorfina-naloxona 8/2, omeprazol 20 mg, diazepam 10 mg, olanzapina 5 mg, pregabalina 150 mg, venlafaxina 150 mg y acetato de eslicarbazepina 1600 mg. En actualidad, fumadora, no otros hábitos tóxicos, Como patología somática padece HTA a tratamiento con diuréticos, hipercolesterolemia, hipertriglicerinemia, antecedentes de hepatitis C y obesidad mórbida acompañado por síndrome hipoventilatorio.
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"PV-058 - SUSTANCIAS DE CONSUMO DETECTADAS EN PACIENTES DUALES QUE INGRESAN EN LA UNIDAD DE AGUDOS DE PSIQUIATRÍA DEL HOSPITAL DE MATARÓ." In 24 CONGRESO DE LA SOCIEDAD ESPAÑOLA DE PATOLOGÍA DUAL. SEPD, 2022. http://dx.doi.org/10.17579/abstractbooksepd2022.pv058.

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Objetivos Describir sustancias de consumo en pacientes duales que ingresan en la Unidad de agudos de psiquiatría del H. de Mataró entre octubre- diciembre 2021. Material-métodos Pacientes ingresados tipo dual se analizan las sustancias de consumo principal y secundarias. Resultados- conclusiones Del total de 195 ingresos en unidad de agudos, un 27.1% (n=52) eran de perfil dual, el 61.5% de los pacientes hombres (n=32) y con edad media 50.5 años. La sustancia principal más frecuente cánnabis 34.6% (n=18), cocaína 21.2% (n=11) y alcohol 19.2% (n=10); anfetaminas 13.5% (n=7), hipnosedantes 7.6% (n=4) y óxido nitroso 2% (n=1). Consumos comórbidos: nicotina 65.38% (n=34), alcohol 53.8% (n=28); cánnabis 30.7% (n=16); cocaína 23.1% (n=12); hipnosedantes 15.3% (n=8); anfetaminas 9.6% (n=5), xantinas 9.6%. Metanfetamina 3.8% (n=2), opiáceos 5.7% (n=3), y 2% (n=1-respectivamente): GHB, estramonio, ketamina, Popper. Cánnabis: alguna vez 83% (n=43), habitual 70% (n = 26), marihuana 53% (n=18), hachís 43% (n=15) y CBD 3% (n=1). Consumo medio 0.75-1g/día. Cocaína: alguna vez 75% (n=39), habitual 29% (n= 9). El 93% inició esnifada (n=28) y 7% (n=2) inhalada; actualmente esnifado 70% (n=14), inhalado 20% (n=4), fumado 5% (n=1) e inyectado 5%. Consumo medio 0.8g/d. Anfetaminas: ocasional 33% (n=17), habitual 58% (n=7), vía esnifada. Hipnosedantes: 33% (n=17) habían consumido, de los cuales habitualmente 75% (n=9): Diazepam 29.4% (n = 5); Clonazepam 29.4% (n=5), Lorazepam 23.5% (n=4) y Alprazolam 17.6% (n=3), Midazolam 11.7% (n=2); y Lormetazepam 5.8% (n=1). Dosis media 53mg/d equivalentes-Diazepam. Opiáceos: heroína alguna vez 13% (n= 7), ninguno habitual; opiáceos no-heroína 4% (n=2). Tabaco: 79% (n= 41), habitual 80.5% (n=33), tipo procesado 75.7% (n=25) y de liar el 24.2% (n=8). Media de 20 unidades/día. Se registró ChemSex 2% (n=1). Conclusiones: Resultados de acuerdo a fuentes principales: Informe-Europeo-Drogas 2021 y ESTUDES-2021-OEDA: incrementa cánnabis en adulto-joven, mantenimiento de tabaco y alcohol, descenso psicoestimulantes y retroceso opiáceos.
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Reports on the topic "Diazepam"

1

Rizzuto, Anthony P., Glenn F. Wilson, Ronald E. Yates, and Regina Palmer. Diazepam and Its Effects on Psychophysiological Measures of Performance. Defense Technical Information Center, 1985. http://dx.doi.org/10.21236/ada168750.

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