Relevant bibliographies by topics / Diazepin

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Diazepin'

Author: Grafiati
Published: 5 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Diazepin"

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Dzedulionytė, Karolina, Melita Veikšaitė, Vít Morávek, et al. "Convenient Synthesis of N-Heterocycle-Fused Tetrahydro-1,4-Diazepinones." Molecules 27, no. 24 (2022): 8666. http://dx.doi.org/10.3390/molecules27248666.

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A general approach towards the synthesis of tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepin-4-one, tetrahydro[1,4]diazepino[1,2-a]indol-1-one and tetrahydro-1H-benzo[4,5]imidazo[1,2-a][1,4]diazepin-1-one derivatives was introduced. A regioselective strategy was developed for synthesizing ethyl 1-(oxiran-2-ylmethyl)-1H-pyrazole-5-carboxylates from easily accessible 3(5)-aryl- or methyl-1H-pyrazole-5(3)-carboxylates. Obtained intermediates were further treated with amines resulting in oxirane ring-opening and direct cyclisation—yielding target pyrazolo[1,5-a][1,4]diazepin-4-ones. A straightforward tw
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Zemanová, Ivana, Michaela Potančoková, and Renata Gašparová. "Synthesis of 4-OXO-4H-Chromene Derivative with Fused Benzodiazepine Ring." Nova Biotechnologica et Chimica 15, no. 1 (2016): 85–89. http://dx.doi.org/10.1515/nbec-2016-0009.

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Abstract 6-Acetylbenzo[b]chromeno[2,3-e][1,4]diazepin-13(6H)-one 6 was synthesized by reaction of 4- oxo-4H-chromene-3-carboxaldehyde 1 with 1,2-diaminobenzene 2 followed by cyclisation of formed Schiff base 3 and spontaneous oxidation of dihydrodiazepine 4 by air oxygen. Finally, diazepine 5 was acetylated at N(6) by reaction with acetic anhydride.
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Addicott, Chris, and Curt Wentrup. "1H-1,3-Diazepines and Ketenimines from Cyanotetrazolopyridines." Australian Journal of Chemistry 61, no. 8 (2008): 592. http://dx.doi.org/10.1071/ch08252.

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Cyano-substituted tetrazolo[1,5-a]pyridines/2-azidopyridines 8T and 15T undergo thermal ring opening to the azides 8A and 15A. Solution photolysis causes nitrogen elimination and ring expansion to 1,3-diazacyclohepta-1,2,4,6-tetraenes 10 and 17, which react with alcohols to afford 2-alkoxy-1H-1,3-diazepines, with secondary amines to 2-dialkylamino-5H-1,3-diazepines, and with water to 1,3-diazepin-2-ones (12–14, 19, 21). Argon matrix photolysis of the azides affords the diazacycloheptatetraenes 10 and 17 as principal products together with ring-opened dicyanovinylketenimines 11 and 18. The matr
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Odame, F., T. Madanhire, E. C. Hosten, and K. Lobb. "Crystal structure, Hirshfeld surface analysis and computational studies of two benzo[b] [1,4]diazepine derivatives." Журнал структурной химии 64, no. 12 (2023): 119104. http://dx.doi.org/10.26902/jsc_id119104.

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The DFT computational studies, crystal structures and Hirshfeld surface analysis of (E)-4-(2-chlorostyryl)-2,2-dimethyl-2,3-dihydro-1H-benzo[b][1,4]diazepine (1) and (E)-4-(2-(2,2-dimethyl-2,3-dihydro-1H-benzo[b][1,4]diazepin-4-yl)vinyl)phenol (2) have been presented. The compounds crystallized in the monoclinic space group P21/c with 4 molecules in their unit cells each. The experimental and computed bond lengths and bond angles deviated from each other to some extent but also showed good agreement with each other in some cases. Hirshfeld surface analysis of the compounds provided further inf
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Patel, Anil S., Hasmukh R. Khunt, Satish M. Ghelani, Jayesh S. Babariya, Kalpesh V. Vilapara, and Yogesh T. Naliapara. "Two Step One-Pot Synthesis of Novel 5-(4-Fluorophenyl)-1H-Beno[e][1,4]Diazepin-2(3H)-One and it’s Base Catalyzed Transformation to N-Alkyl and C-3 Arylidene Derivatives." International Letters of Chemistry, Physics and Astronomy 30 (March 2014): 106–15. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.30.106.

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We have demonstrated two step one-pot synthesis of novel 5-(4-Fluorophenyl)-1H-Beno[e][1,4]Diazepin-2(3H)-one using 2-Amino-4’-fluorobenzophenone as initial stating material. The small library of N-alkylation and C-3 benzylidene derivatives have been synthesized by base catalyzedreaction of 5-(4-fluorophenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one (3) nucleus with various alkyl halides and aromatic aldehydes respectively.
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Patel, Anil S., Hasmukh R. Khunt, Satish M. Ghelani, Jayesh S. Babariya, Kalpesh V. Vilapara, and Yogesh T. Naliapara. "Two Step One-Pot Synthesis of Novel 5-(4-Fluorophenyl)-1<i>H</i>-Beno[e][1,4]Diazepin-2(3<i>H</i>)-One and it’s Base Catalyzed Transformation to <i>N</i>-Alkyl and C-3 Arylidene Derivatives." International Letters of Chemistry, Physics and Astronomy 30 (March 12, 2014): 106–15. http://dx.doi.org/10.56431/p-9l954w.

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We have demonstrated two step one-pot synthesis of novel 5-(4-Fluorophenyl)-1H-Beno[e][1,4]Diazepin-2(3H)-one using 2-Amino-4’-fluorobenzophenone as initial stating material. The small library of N-alkylation and C-3 benzylidene derivatives have been synthesized by base catalyzedreaction of 5-(4-fluorophenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one (3) nucleus with various alkyl halides and aromatic aldehydes respectively.
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Capuano, Ben, Ian T. Crosby, Edward J. Lloyd, Juliette E. Neve, and David A. Taylor. "Aminimides as Potential CNS Acting Agents. I. Design, Synthesis, and Receptor Binding of 4′-Aryl Aminimide Analogues of Clozapine as Prospective Novel Antipsychotics." Australian Journal of Chemistry 60, no. 9 (2007): 673. http://dx.doi.org/10.1071/ch07197.

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A series of substituted 1-[4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-methylhexahydropyrazin-1-ium]-1-aminimide derivatives were designed on the basis of the physicochemical properties of the aminimide functional group and synthesized as potential antipsychotic agents for the treatment of schizophrenia. The target compounds were readily prepared in two steps from clozapine (8-chloro-11-(4-methylpiperazino)-5H-dibenzo[b,e][1,4]diazepine) and involved N-acylation of a common hydrazinium salt intermediate by an acyl chloride or activated ester in the presence of a strong base. The aminimid
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Bennamane, Norah, Oualid Talhi, Artur Silva, et al. "Dibenzo[b,e][1,4]diazepin-1-ones and their Ring-Opened Derivatives: Revisited Synthesis, 2D NMR and Crystal Structure." Synlett 28, no. 17 (2017): 2247–52. http://dx.doi.org/10.1055/s-0036-1590306.

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The synthesis of 2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-ones was revisited and a catalyst-free method was established, by exploring the reactivity of 3-[(2-aminoaryl)amino]dimedones towards carbonylated electrophiles. 2D NMR and single-crystal X-ray diffraction studies were used to characterize the structures unequivocally and to review the mechanism leading to the formation of supposed positional isomers. The action of 3-[(2-aminoaryl)amino]dimedones on chromene-3-carboxylic acid, fumaryl, and oxalyl chloride has led to dibenzo[b,e][1,4]diazepin-1-one ring opening to produce n
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Iden, Hassan S., and William D. Lubell. "1,3,5-Trisubstituted 1,4-Diazepin-2-ones." Journal of Organic Chemistry 72, no. 23 (2007): 8980–83. http://dx.doi.org/10.1021/jo701467d.

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Xu, Xin-Ming, Sen Chen, Shao-Lei Duan, Xiang-Min Wang, Qian Liu, and Kai Sun. "Synthesis of 1,4-Benzodiazepines via Intramolecular C–N Bond Coupling and Ring Opening of Azetidines." Molecules 30, no. 9 (2025): 2014. https://doi.org/10.3390/molecules30092014.

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A facile and efficient synthesis of functionalized 1,4-benzodiazepine derivatives under mild conditions was developed. The CuI/N,N-dimethylglycine-catalyzed intramolecular cross-coupling reaction of 1-(2-bromobenzyl)azetidine-2-carboxamides proceeded smoothly under mild conditions to provide 1,4,9,10a-tetrahydroazeto[1,2-a]benzo[e][1,4]diazepin-10(2H)-ones. The resulting azetidine-fused 1,4-benzodiazepine compounds underwent consecutive N-methylation with methyl triflate and the opening of the four-membered heterocyclic ring by NaN3, KCN and PhSNa to produce diverse 1,4-benzodiazepine derivati
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Dissertations / Theses on the topic "Diazepin"

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Nouvet, André. "Synthèse en solution, en phases liquide et solide de peptidomimétiques contraints à base de perhydro-(1,4)-diazepin-2-ones." Montpellier 2, 1998. http://www.theses.fr/1998MON20111.

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L'utilisation de peptides natifs en tant que medicaments se heurte a des inconvenients inherents a leur metabolisme et a leur manque de specificite. C'est dans le but de resoudre ces problemes que l'axe de recherche concernant les peptidomimetiques contraints a ete developpe. Nous avons synthetise des perhydrodiazepinones dont la structure s'apparente a celle des coudes presents dans certains peptides. Dans ce manuscrit, nous avons decrit differentes voies de synthese dont la principale implique une reaction de mitsunobu afin de realiser l'etape-clef de cyclisation. Cette strategie de synthese
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Sulier, Kiaya Minh-Li. "Developing 1,2,3,4-tetrahydro-5H-aryl[1,4]diazepin-5-ones and Related Scaffolds as Poly-(ADP-ribosyl) Polymerase (PARP) Inhibitors and Exploring Their Targeted Polypharmacology with Kinases." Thesis, Virginia Tech, 2017. http://hdl.handle.net/10919/86200.

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Poly-(ADP-ribsoyl) Polymerases (PARPs) are a superfamily of enzymes comprised of 17 known isoforms. PARP inhibitors (PARPi) have shown success in clinical trials for the treatment of homologous recombination-deficient cancers. Though proven effective initially, tumors treated with PARPi eventually develop resistance. Combinatorial therapeutics targeting PARP and other pathways that may re-sensitize tumors to PARP inhibition, including PI3K/AKT/mTor pathway, and cell-cycle checkpoints (such as CDKs, CHK, and Wee) are being tested. In this context, the synthetic lethality of cyclin-dependent kin
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Santos, Alessandro Casale dos. "PARTICIPAÇÃO DO SISTEMA GABAérgico NO MECANISMO DE AÇÃO ANESTÉSICA DOS ÓLEOS ESSENCIAIS DE Aloysia triphylla E Cymbopogon flexuosus EM JUNDIÁS (Rhamdia quelen)." Universidade Federal de Santa Maria, 2016. http://repositorio.ufsm.br/handle/1/9028.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>This study demonstrated the sedative and anesthetic activity of the essential oil (EO) of Cymbopogon flexuosus in the silver catfish (Rhamdia quelen). The time for induction and recovery of this EO was compared with the EO of Aloysia triphylla, due to the similarity between their major components: α-citral (geranial) and β-citral (neral). Both EOs induced anesthesia at concentrations from 150 to 300 μL L-1 and sedation at 25 μL L-1. The EO of C. flexuosus was faster in inducing the initial stages of anesthesia, but there was no sig
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Silva, Sílvia Raquel Filipe da. "Farmacocinética do diazepam." Master's thesis, [s.n.], 2013. http://hdl.handle.net/10284/3978.

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Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas<br>O diazepam é um princípio ativo do grupo farmacológico das benzodiapezinas, do qual é o mais representativo, sendo por muitos considerado a molécula modelo deste grupo. É largamente utilizado no tratamento de ansiedades e outros distúrbios físicos e psicológicos associados às mesmas. De forma a optimizar os resultados da prática clínica, considerando o factor variabilidade interindividual, é essencial recorrer à monitorização ter
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Aerden, Leo Adrianus Maria. "Diazepam in acute stroke /." [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Universiteit Maastricht [host], 2006. http://arno.unimaas.nl/show.cgi?fid=5836.

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Barbour, Carol J. "Analytical studies on diazepam." Thesis, University of Strathclyde, 1987. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=21481.

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Assay methods have been developed which are specific for the analysis of diazepam in the presence of formulation excipients, closely related degradation products and manufacturing impurities. The methods developed used difference ultraviolet spectrophotometry and HPLC. These methods have been applied to the analysis of diazepam in formulations and to investigate the reaction kinetics of the acid hydrolysis of diazepam. From analysis of both fresh and stored samples of formulations, it was seen that solid dosage forms showed no degradation, but degradation products were detected in liquid formu
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Hofmann, Thorsten. "Synthese und Reaktionen von Cyclopenta[c]1,2-diazepinen und Cyclopenta[d]1,2-diazepinen." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=963775774.

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Rocha, Vanessa de Moraes. "Efeito do esteroide anabolico nandrolona sobre o nivel de ansidade em ratos." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/288845.

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Orientador: Fernanda Klein Marcondes<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-08T02:16:22Z (GMT). No. of bitstreams: 1 Rocha_VanessadeMoraes_M.pdf: 1061559 bytes, checksum: 4455455a00850fa30a24f9a89ea8dd5e (MD5) Previous issue date: 2006<br>Resumo: Os esteróides androgênicos anabólicos (EAA) são usados no tratamento de hipogonadismo masculino, andropausa associada ao envelhecimento, osteoporose, anemia associada à doença renal crônica, síndrome de imunodeficiência adquirida, politraumatismo e
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Wilpert, Carsten. "Pyrido[3,2-e][1,4]diazepine : Synthese und Prüfung auf Anti-HIV-1-Wirkung /." [S.l. : s.n.], 1995. http://www.gbv.de/dms/bs/toc/184661447.pdf.

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Raihane, Mohamed. "Reactions d'annelation en serie imidazo(1,2-a)pyridine : acces aux systemes pyridoimidazo(iso)quinoleiniques et imidazopyridodiazepiniques isosteres de tibo." Clermont-Ferrand 1, 1996. http://www.theses.fr/1996CLF1PP01.

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Books on the topic "Diazepin"

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Ian, Fryer R., ed. Bicyclic diazepines: Diazepines with an additional ring. Wiley, 1991.

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Reiter, Susanne. Digoxinspiegelveränderungen nach einmaliger Diazepam-Gabe. [s.n.], 1985.

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Kaiser, Claudia. Farbsalze von Thieno- und Benzo[1,4]diazepinen. [s.n.], 1985.

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Rauh, Hans Werner. Dikaliumclorazepat und Diazepam bei Niereninsuffizienz, Serumkonzentrationen und Proteinbindung von Diazepam und Desmethyldiazepam: Gleichzeitig ein Beitrag zur Pharmakologie der Benzodiazepine. [s.n.], 1985.

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Winger, Gail. Valium and other tranquilizers. Chelsea House Publishers, 1992.

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Small, Cathleen. Valium and other antianxiety drugs. Cavendish Square Publishing, 2016.

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Barbara, Gordon. I'm dancing as fast as I can. 3rd ed. Beaufort Books, 2011.

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Beischlag, Timothy V. P. C. The effect of mephenytoin on diazepam metabolism in rat and man. National Library of Canada, 1990.

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Joint Epilepsy Council of the UK and Ireland. A guideline on training standards for the administration of rectal diazepam. Joint Epilepsy Council of the UK and Ireland, 2000.

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Parker, Philip M., and James N. Parker. Diazepam: A medical dictionary, bibliography, and annotated research guide to Internet references. ICON Health Publications, 2003.

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Book chapters on the topic "Diazepin"

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Iden, Hassan S., and William D. Lubell. "Solid-Phase Synthesis of 1,3,5-Trisubstituted 1,4-Diazepin-2-one Peptide Mimic." In Advances in Experimental Medicine and Biology. Springer New York, 2009. http://dx.doi.org/10.1007/978-0-387-73657-0_98.

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Deaudelin, Philippe, and William D. Lubell. "Synthesis of pyrrolo[3,2-e][1,4]diazepin-2-ones as potential γ-turn mimetics." In Advances in Experimental Medicine and Biology. Springer New York, 2009. http://dx.doi.org/10.1007/978-0-387-73657-0_84.

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Benkert, Otto, Ion Anghelescu, Christoph Fehr, et al. "Diazepam." In Pocket Guide Psychopharmaka von A bis Z. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-01910-4_31.

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Courtney, John C. "Diazepam." In Encyclopedia of Clinical Neuropsychology. Springer New York, 2011. http://dx.doi.org/10.1007/978-0-387-79948-3_1649.

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Beyer, Karl-Heinz. "Diazepam." In Biotransformation der Arzneimittel. Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-74386-3_103.

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Courtney, John C., and Efrain Antonio Gonzalez. "Diazepam." In Encyclopedia of Clinical Neuropsychology. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-56782-2_1649-2.

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Gonzalez, Efrain Antonio. "Diazepam." In Encyclopedia of Clinical Neuropsychology. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-56782-2_1649-3.

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Gonzalez, Efrain Antonio. "Diazepam." In Encyclopedia of Clinical Neuropsychology. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-57111-9_1649.

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Simola, Nicola, Micaela Morelli, Tooru Mizuno, et al. "Diazepam." In Encyclopedia of Psychopharmacology. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_1732.

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Balogh, Nicholas J. "Diazepam." In Encyclopedia of Child Behavior and Development. Springer US, 2011. http://dx.doi.org/10.1007/978-0-387-79061-9_3001.

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Conference papers on the topic "Diazepin"

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Shutalev, Anatoly, and Anastasia Fesenko. "Ring Expansion Tetrahydropyrimidin-2-ones into Tetrahydro-1H-1,3-diazepin-2-ones: a Theoretical Study." In The 21st International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2017. http://dx.doi.org/10.3390/ecsoc-21-04766.

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Shutalev, Anatoly, and Anastasia Fesenko. "Diastereoselectivity in the Ring Expansion of Tetrahydropyrimidin-2-ones into Tetrahydro-1H-1,3-diazepin-2-ones." In The 19th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2015. http://dx.doi.org/10.3390/ecsoc-19-a034.

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COLPINI, L. M. S., G. N. SILVA, L. E. N. CASTRO, et al. "DEGRADAÇÃO DO DIAZEPAM POR FOTOCATÁLISE HETEROGÊNEA." In XXII Congresso Brasileiro de Engenharia Química. Editora Blucher, 2018. http://dx.doi.org/10.5151/cobeq2018-pt.0971.

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Aguiar, Beatriz Rosa de Oliveira, and SHARLENE LOPES PEREIRA. "INTERAÇÕES ALIMENTARES ESTÃO ADEQUADAMENTE DESCRITAS NAS BULAS DO DIAZEPAM?" In I Congresso Nacional de Saúde Coletiva On-line. Revista Multidisciplinar em Saúde, 2023. http://dx.doi.org/10.51161/conasc/21755.

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Okkesim, Cukru, Musa Hakan Asyali, Sadik Kara, and Mehmet Gungor Kaya. "Effect of diazepam on the sempatovagal balance and O2 saturation." In 2010 15th National Biomedical Engineering Meeting (BIYOMUT 2010). IEEE, 2010. http://dx.doi.org/10.1109/biyomut.2010.5479858.

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Sanz, Dionisia, Ana Andrade, Rosa M. Claramunt, and José Elguero. "Synthesis and Structural Characterization of 1,4-Diazepines Related to Curcumin." In The 19th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2015. http://dx.doi.org/10.3390/ecsoc-19-a044.

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Barbosa, R., A. Capela, C. Sampaio, et al. "3PC-028 Compounding an oral liquid formulation of diazepam alcohol free." In 25th EAHP Congress, 25th–27th March 2020, Gothenburg, Sweden. British Medical Journal Publishing Group, 2020. http://dx.doi.org/10.1136/ejhpharm-2020-eahpconf.75.

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Schürfeld, Robin, Benjamin Sandner, Annett Hoffmann, et al. "Renal function is a major predictor of circulating acyl-CoA-binding protein/diazepam-binding inhibitor." In Diabetes Kongress 2023 - 57. Jahrestagung der DDG. Georg Thieme Verlag, 2023. http://dx.doi.org/10.1055/s-0043-1767932.

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Alasadi, Yuosra K., Fawzi Hameed Jumaa, and Adil Hussein Dalaf. "Synthesis, identification, antibacterial activity and laser effect of new derivatives of bis-1,3-oxazepene-4,7-dione and 1,3-diazepine-4,7-dione." In 1ST SAMARRA INTERNATIONAL CONFERENCE FOR PURE AND APPLIED SCIENCES (SICPS2021): SICPS2021. AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0121358.

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Damasceno Júnior, Eustáquio Costa, Isabella Sabião Borges, João Victor Aguiar Moreira, et al. "Successful treatment with rituximab in a refractory Stiffperson syndrome (SPS)." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.507.

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Background: SPS is a disorder consisting of rigidity of axial muscles with painful spasms. More than 80 % of SPS patients have high titer antibodies against glutamic acid decarboxylase (GAD). The use of rituximab for the treatment of SPS is a recent therapeutical approach showing promising results. We present a case of SPS treated with rituximab, showing a good and safe response. Case: A 38-year-old female patient presented with a history of rigidity of abdominal and paravertebral muscles associated with painful spasms in lower back region, increased tonus, lumbar lordosis, frequent falls and
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Reports on the topic "Diazepin"

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Rizzuto, Anthony P., Glenn F. Wilson, Ronald E. Yates, and Regina Palmer. Diazepam and Its Effects on Psychophysiological Measures of Performance. Defense Technical Information Center, 1985. http://dx.doi.org/10.21236/ada168750.

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