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Dissertations / Theses on the topic 'Diazepin'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Nouvet, André. "Synthèse en solution, en phases liquide et solide de peptidomimétiques contraints à base de perhydro-(1,4)-diazepin-2-ones." Montpellier 2, 1998. http://www.theses.fr/1998MON20111.

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L'utilisation de peptides natifs en tant que medicaments se heurte a des inconvenients inherents a leur metabolisme et a leur manque de specificite. C'est dans le but de resoudre ces problemes que l'axe de recherche concernant les peptidomimetiques contraints a ete developpe. Nous avons synthetise des perhydrodiazepinones dont la structure s'apparente a celle des coudes presents dans certains peptides. Dans ce manuscrit, nous avons decrit differentes voies de synthese dont la principale implique une reaction de mitsunobu afin de realiser l'etape-clef de cyclisation. Cette strategie de synthese

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2

Sulier, Kiaya Minh-Li. "Developing 1,2,3,4-tetrahydro-5H-aryl[1,4]diazepin-5-ones and Related Scaffolds as Poly-(ADP-ribosyl) Polymerase (PARP) Inhibitors and Exploring Their Targeted Polypharmacology with Kinases." Thesis, Virginia Tech, 2017. http://hdl.handle.net/10919/86200.

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Poly-(ADP-ribsoyl) Polymerases (PARPs) are a superfamily of enzymes comprised of 17 known isoforms. PARP inhibitors (PARPi) have shown success in clinical trials for the treatment of homologous recombination-deficient cancers. Though proven effective initially, tumors treated with PARPi eventually develop resistance. Combinatorial therapeutics targeting PARP and other pathways that may re-sensitize tumors to PARP inhibition, including PI3K/AKT/mTor pathway, and cell-cycle checkpoints (such as CDKs, CHK, and Wee) are being tested. In this context, the synthetic lethality of cyclin-dependent kin

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3

Santos, Alessandro Casale dos. "PARTICIPAÇÃO DO SISTEMA GABAérgico NO MECANISMO DE AÇÃO ANESTÉSICA DOS ÓLEOS ESSENCIAIS DE Aloysia triphylla E Cymbopogon flexuosus EM JUNDIÁS (Rhamdia quelen)." Universidade Federal de Santa Maria, 2016. http://repositorio.ufsm.br/handle/1/9028.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>This study demonstrated the sedative and anesthetic activity of the essential oil (EO) of Cymbopogon flexuosus in the silver catfish (Rhamdia quelen). The time for induction and recovery of this EO was compared with the EO of Aloysia triphylla, due to the similarity between their major components: α-citral (geranial) and β-citral (neral). Both EOs induced anesthesia at concentrations from 150 to 300 μL L-1 and sedation at 25 μL L-1. The EO of C. flexuosus was faster in inducing the initial stages of anesthesia, but there was no sig

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4

Silva, Sílvia Raquel Filipe da. "Farmacocinética do diazepam." Master's thesis, [s.n.], 2013. http://hdl.handle.net/10284/3978.

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Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas<br>O diazepam é um princípio ativo do grupo farmacológico das benzodiapezinas, do qual é o mais representativo, sendo por muitos considerado a molécula modelo deste grupo. É largamente utilizado no tratamento de ansiedades e outros distúrbios físicos e psicológicos associados às mesmas. De forma a optimizar os resultados da prática clínica, considerando o factor variabilidade interindividual, é essencial recorrer à monitorização ter

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5

Aerden, Leo Adrianus Maria. "Diazepam in acute stroke /." [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Universiteit Maastricht [host], 2006. http://arno.unimaas.nl/show.cgi?fid=5836.

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6

Barbour, Carol J. "Analytical studies on diazepam." Thesis, University of Strathclyde, 1987. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=21481.

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Assay methods have been developed which are specific for the analysis of diazepam in the presence of formulation excipients, closely related degradation products and manufacturing impurities. The methods developed used difference ultraviolet spectrophotometry and HPLC. These methods have been applied to the analysis of diazepam in formulations and to investigate the reaction kinetics of the acid hydrolysis of diazepam. From analysis of both fresh and stored samples of formulations, it was seen that solid dosage forms showed no degradation, but degradation products were detected in liquid formu

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7

Hofmann, Thorsten. "Synthese und Reaktionen von Cyclopenta[c]1,2-diazepinen und Cyclopenta[d]1,2-diazepinen." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=963775774.

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8

Rocha, Vanessa de Moraes. "Efeito do esteroide anabolico nandrolona sobre o nivel de ansidade em ratos." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/288845.

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Orientador: Fernanda Klein Marcondes<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-08T02:16:22Z (GMT). No. of bitstreams: 1 Rocha_VanessadeMoraes_M.pdf: 1061559 bytes, checksum: 4455455a00850fa30a24f9a89ea8dd5e (MD5) Previous issue date: 2006<br>Resumo: Os esteróides androgênicos anabólicos (EAA) são usados no tratamento de hipogonadismo masculino, andropausa associada ao envelhecimento, osteoporose, anemia associada à doença renal crônica, síndrome de imunodeficiência adquirida, politraumatismo e

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9

Wilpert, Carsten. "Pyrido[3,2-e][1,4]diazepine : Synthese und Prüfung auf Anti-HIV-1-Wirkung /." [S.l. : s.n.], 1995. http://www.gbv.de/dms/bs/toc/184661447.pdf.

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10

Raihane, Mohamed. "Reactions d'annelation en serie imidazo(1,2-a)pyridine : acces aux systemes pyridoimidazo(iso)quinoleiniques et imidazopyridodiazepiniques isosteres de tibo." Clermont-Ferrand 1, 1996. http://www.theses.fr/1996CLF1PP01.

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11

Hamidi, Parinaz. "Design and synthesis of diazepine inhibitors as novel anti-cancer agents." Thesis, Cardiff University, 2006. http://orca.cf.ac.uk/54275/.

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Cancer is a new growth that arises from abnormal and uncontrolled division of cells that may go on to invade and destroy surrounding tissues. The eukaryotic cell cycle consists of a complex sequence of events that regulates cell division and responses to DNA damage. These processes rely upon several key enzymes, including the cyclin dependent kinases (CDKs), checkpoint kinases (Chk2) and poly(ADP-ribose)polymerase-l (PARP-1). CDKs are a family of protein kinases that control progression of the cell cycle, and are themselves regulated by a complex network of activating and inhibitory mechanisms

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12

Nicholson, Martin William. "Diazepam-dependent modulation of GABAergic inhibitory synapses." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10046265/.

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Diazepam is an allosteric modulator of GABAA receptors which potentiates GABAA receptor activity resulting in enhanced inhibitory synaptic transmission. Diazepam is used to treat anxiety, insomnia and seizures, however, its use is limited due to the development of tolerance. Here I show that prolonged treatment of cortical neurones with diazepam triggers endocytosis and subsequent downregulation of cell-surface GABAA receptors. Using pharmacological reagents, I have demonstrated that diazepam triggers PLC-dependent release of calcium from the endoplasmic reticulum which activates the phosphata

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13

Paula, Valéria Veras De. "Efeito da pré-medicação em papagaios (Amazona aestiva), com cloridrato de cetamina isolado ou associado ao diazepam, sobre a indução e anestesia com sevofluorano." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/10/10137/tde-09042007-183459/.

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A pré-medicação apesar de ser freqüentemente utilizada nos mamíferos, é raramente utilizada nas espécies aviárias. O objetivo deste estudo foi avaliar o efeito da pré-medicação na indução e anestesia com sevofluorano em papagaios. Foram utilizados trinta e seis animais adultos oriundos do Parque ecológico do Tietê. Os animais foram randomicamente distribuídos em três grupos: grupo I (n = 12), tratado com NaCl 0,9% como placebo, grupo II (n = 12), com cetamina 10 mg.Kg-1 e grupo III (n = 12), com cetamina 10 mg.Kg-1 e diazepam 0,5 mg.Kg-1, por via intramuscular. Quinze minutos após a pré-medica

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14

Battrum-Mounts, Deborah E. "A comparison of two conventional sedatives-diazepam and droperidol in combination with fentanyl in surgical patients." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/24474.

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One hundred patients who were to have cataract extraction and intraocular lens replacement carried out were randomly assigned to one of two drug groups. The purpose was to compare droperidol/ fentanyl and diazepam/fentanyl for the following effects: central nervous system depression, cardiovascular depression and ability to alleviate anxiety. Patients, psychology observes, and surgeons were not cognizant of others' opionons, nor of assignment of drug treatment group. Experimental design was a between group single treatment design. Psychological testing consisted of State-Trait Anxiety Inventor

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15

Gomes, Sandra Terezinha Marques. "Desenvolvimento de um eletrodo de pasta de carbono modificado para acumulação e determinação voltametrica de diazepan." [s.n.], 1997. http://repositorio.unicamp.br/jspui/handle/REPOSIP/248498.

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Orientadores: Luiz Manoel Aleixo, Oswaldo E. S. Godinho<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Quimica<br>Made available in DSpace on 2018-07-23T06:59:49Z (GMT). No. of bitstreams: 1 Gomes_SandraTerezinhaMarques_D.pdf: 3400371 bytes, checksum: f579f07964f5142b6020fa1c3dd23fc8 (MD5) Previous issue date: 1997<br>Doutorado

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16

Reid, Lee. "What role does the Î±1-GABAâ†A receptor subtype play in mediating the development of tolerance, dependence, and sensitisation following long-term exposure to benzodiazepines?" Thesis, University of Sussex, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250006.

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17

Tomita, Laura Mendes. "Uma descrição funcional do comportamento da criança no contexto odontopediatrico." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/288678.

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Orientador: Antonio Bento Alves de Moraes<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-12T20:02:19Z (GMT). No. of bitstreams: 1 Tomita_LauraMendes_D.pdf: 494168 bytes, checksum: 6212c45d72e7cbbd71b1e651b4e6c3b6 (MD5) Previous issue date: 2009<br>Resumo: A experiência odontológica pode ser considerada uma situação potencialmente geradora de ansiedade para a criança; esta situação envolve um conjunto de variáveis desconhecidas e invasivas que podem desencadear respostas que caracterizam desconforto e sofr

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18

Wolfe, Steven Scott. "Uterine uptake of diazepam and quantification by gas chromatography/mass spectrometry." Morgantown, W. Va. : [West Virginia University Libraries], 2003. http://etd.wvu.edu/templates/showETD.cfm?recnum=2957.

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Thesis (M.S.)--West Virginia University, 2003.<br>Title from document title page. Document formatted into pages; contains vii, 70 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 69-70).

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19

Silva, Frederico Andrade e. 1948. "Efeito do diazepam na secreção salivar e na atividade metabolica da glandula submandibular de ratos." [s.n.], 1989. http://repositorio.unicamp.br/jspui/handle/REPOSIP/289286.

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Orientador: Jaime Aparecido Cury<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-07-14T04:04:25Z (GMT). No. of bitstreams: 1 Silva_FredericoAndradee_D.pdf: 1287739 bytes, checksum: 50d7be71d9f7ffdbb0dfa042aa377c81 (MD5) Previous issue date: 1989<br>Resumo: Uma série de medicamentos podem modificar o fluxo salivar e provocar xerostomia com efeitos indesejáveis à cavidade bucal. Dentre estas drogas encontram-se os antidepressivos largamente utilizados pela população. Procurou-se neste trabalho estudar o efeito

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20

LAGARDE, CLAIRE. "Intoxication aigue par la chloroquine." Lille 2, 1997. http://www.theses.fr/1997LIL2P052.

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21

Arrunátegui, Lorena Barbosa. "Avaliação biofarmacêutica do diazepam visando subsidiar discussão sobre bioisenção." reponame:Repositório Institucional da UFOP, 2013. http://www.repositorio.ufop.br/handle/123456789/5731.

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Programa de Pós-Graduação em Ciências Farmacêuticas. CIPHARMA, Escola de Farmácia, Universidade Federal de Ouro Preto.<br>Submitted by Oliveira Flávia (flavia@sisbin.ufop.br) on 2015-10-14T20:50:06Z No. of bitstreams: 2 license_rdf: 22190 bytes, checksum: 19e8a2b57ef43c09f4d7071d2153c97d (MD5) DISSERTAÇÃO_AvaliaçãoBiofarmacêuticaDiazepam.pdf: 1691374 bytes, checksum: 187fa5033c104983097e5b0f6a39ea5b (MD5)<br>Approved for entry into archive by Gracilene Carvalho (gracilene@sisbin.ufop.br) on 2015-11-04T17:05:03Z (GMT) No. of bitstreams: 2 license_rdf: 22190 bytes, checksum: 19e8a2b57ef43c0

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22

Nascimento, Jedson dos Santos [UNESP]. "Efeitos sedativos e cardiovasculares do midazolam e do diazepam associados ou não à clonidina, em pacientes submetidos a estudos hemodinâmicos por suspeitas de doença arterial coronariana." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/106013.

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Made available in DSpace on 2014-06-11T19:35:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2007-02-27Bitstream added on 2014-06-13T19:05:32Z : No. of bitstreams: 1 nascimento_js_dr_botfm.pdf: 722430 bytes, checksum: e2016c502b8c938e01734e5747ae7a04 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Avaliar a qualidade da sedação e os efeitos sobre a frequencia cardiaca e a pressão arterial do midazolam e do diazepam associados ou nao a clonidina, em pacientes com suspeita de doenca coronariana. Métodos: Foi desenvolvido ensaio clinico prospectivo, duplo ce

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23

Hamaguchi, Anzu. "Molecular and cellular pharmacology of novel pyrrolo [2,1-c] [1,4] diazepine-based anticancer agents." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1444728/.

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The pyrrolo 2,1-c 1,benzodiazepines (PBDs) are a family of naturally occurring antitumour antibiotics which includes anthramycin, DC-81, tomaymycin and sibiromycin. They exert their biological activity through covalent binding to the exocyclic N2 group of guanine in the minor groove of DNA and block transcription in a sequence-specific manner. These PBD monomers span three DNA base pairs and have a preference for binding to purine-G-purine triplets. The PBDs have been used as a scaffold to attach other moieties, leading to novel sequence-selective DNA minor groove alkylating agents. In additio

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24

Neis, Christian [Verfasser], and Kaspar [Akademischer Betreuer] Hegetschweiler. "Koordinationschemische Eigenschaften von Pyridylmethylderivaten des 1,4-Diazepan-6-amins / Christian Neis. Betreuer: Kaspar Hegetschweiler." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2009. http://d-nb.info/105233864X/34.

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25

Bratenko, M. K. "Modern organic synthesis of pyrazolo[3,4-e][1,2,3]triazolo[1,5-a]diazepine-3-carboxamides." Thesis, БДМУ, 2020. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18354.

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26

Barioni, Éric Diego. "Interferência do TSPO sobre as vias de ativação de adipócitos da linhagem 3T3-L1." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/9/9141/tde-03042018-155412/.

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A obesidade está associada a um processo inflamatório crônico de baixa intensidade e representa um dos fatores de risco para o desenvolvimento de uma série de comorbidades. A proteína TSPO está envolvida em inúmeras funções celulares, incluindo biossíntese e transporte de esteróides, transporte de porfirinas, apoptose, biossíntese do heme, processos oxidativos e imunomodulação. Ademais, a presença e a função da proteína TSPO no tecido adiposo e na inflamação ainda não estão bem estabelecidas. Deste modo, o objetivo do presente estudo foi validar a expressão e função do TSPO durante a diferenci

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27

Szakacs, Cameron Benjamin Neil. "Effects of feeding on the disposition of lorazepam and diazepam." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq23884.pdf.

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28

Fernandes, Catherine. "Factors influencing the development of diazepam dependence in the rat." Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339194.

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29

West, Charles Edward. "The photodegradation of diazepam and its human metabolites in water." Thesis, University of Plymouth, 2007. http://hdl.handle.net/10026.1/2254.

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In recent years, the environmental occurrence, fate and effects of pharmaceuticals or pharmaceutically active compounds (PhACs) and their metabolites have received increased attention. PhACs have been detected in wastewater, river water, marine waters and even sewage sludge and soil. Since PhACs are developed with the intention of stimulating or inhibiting physiological responses, these findings have prompted concern over their environmental fate and potential adverse effects on nontarget ecological species. The major source of discharge of PhACs to the environment is through sewage treatment

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30

Dunworth, Sarah Jane. "Investigations into the consequences of single and repeated Diazepam withdrawal." Thesis, University of Sussex, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310967.

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31

Riley, Christine Marie 1964. "The effect of triacetin on solubility of diazepam and phenytoin." Thesis, The University of Arizona, 1990. http://hdl.handle.net/10150/277304.

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The effect of triacetin in combination with common cosolvents on the solubility of phenytoin and diazepam was studied. The cosolvents were PEG 400 and propylene glycol. In addition, the data were used to test the following model: UNFORMATTED EQUATION FOLLOWS: log Sᵈ(c,p,w) = log Sᵈ(w) + f(c)σᵈ(c) + [Sᵖ(w)10(f(c)σᵖ(c))/D(p)] σᵈ(p). UNFORMATTED EQUATION ENDS. The term on the left side of the equation is the solubility of a drug in the ternary system. This is related to the aqueous solubility of the drug, the solubility of the drug in a completely miscible organic solvent (CMOS), and the solubili

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32

Hakmi, Selem Chain. "Estudo de uma associação analgesica/tranquilizante (acido acetilsalicilico e diazepam) em cirurgias odontologicas (exodontia simples e terceiros molares inclusos." [s.n.], 1988. http://repositorio.unicamp.br/jspui/handle/REPOSIP/288060.

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Orientador: Maria de Lourdes Garboggini da Gama<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-07-17T17:46:38Z (GMT). No. of bitstreams: 1 Hakmi_SelemChain_M.pdf: 1254972 bytes, checksum: 6973e0b80a6434e9a0d72f14d430bd2c (MD5) Previous issue date: 1988<br>Resumo: Não informado<br>Abstract: Not informed.<br>Mestrado<br>Mestre em Odontologia

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Ribeiro, Carmen Sylvia. "Consumo cronico de diazepam por pacientes atendidos em unidades basicas de saude de Campinas." [s.n.], 2001. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311449.

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Orientador : Neury Jose Botega<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-07-31T19:14:53Z (GMT). No. of bitstreams: 1 Ribeiro_CarmenSylvia_M.pdf: 23696444 bytes, checksum: 9a057eb3e2a9fc3eb6252466beeda5e9 (MD5) Previous issue date: 2001<br>Resumo: o objetivo desta pesquisa é investigar aspectos relacionados ao uso crônico de benzodiazepínicos, no caso, o diazepam. Foram estudados 41 pacientes, provenientes de selViços de atenção primária á saúde em Campinas, e que receberam prescrição desse fármacopor tempo

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34

Demazière, Jacques. "Intoxications aigues par la chloroquine a dakar : efficacite du diazepam, facteurs previsionnels de deces ; etude retrospective de 360 observations." Lyon 1, 1993. http://www.theses.fr/1993LYO1M042.

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35

Vidailhet, Pierre. "Les effets du lorazepam et du diazepam sur la memoire explicite et sur l'amorcage perceptif chez le volontaire sain : une analyse des mecanismes cognitifs (doctorat : psychopharmacologie)." Strasbourg 1, 1999. http://www.theses.fr/1999STR15053.

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36

Jauer, Stephan. "Bestimmung und Modellierung der Initiatoreffektivität von Diazenen in der Ethen-Hochdruckpolymerisation." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=976941236.

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37

Hughes, Dyfrig Arwyn. "Mechanistic studies on the effects of diazepam on chloroquine-induced cardiotoxicity." Thesis, University of Liverpool, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243244.

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38

Allison, Claire. "Investigations of regional changes in AMPA receptor characteristics during diazepam withdrawal." Thesis, University of Strathclyde, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249020.

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39

Ribeiro, Mayron Pereira Picolo. "Efeito do diazepam sobre o grooming induzido por contenção em ratos." Universidade Estadual de Londrina. Centro de Ciências Biológicas. Programa de Pós-Graduação em Análise do Comportamento, 2016. http://www.bibliotecadigital.uel.br/document/?code=vtls000209701.

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Um importante recurso para o estudo da ansiedade é o uso de modelos animais, pois permitem investigações de situações e de comportamentos relacionados à ansiedade que seriam inviáveis em estudos com humanos. Nesse sentido, o comportamento de grooming tem sido estudado em roedores quanto à sua relação com o estresse. Embora haja evidências dessa relação, estudos recentes têm relacionado o grooming com momentos de desexcitação e não necessariamente de estresse. O objetivo do presente estudo foi investigar como a resposta de grooming induzido por contenção pode ser modulada por diferentes doses d

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40

Figueiredo, Raul Sebastião 1981. "Confecção e caracterização de eletrodos tridimensionais de PbO2 e PbO2/SnOx produzidos por anodização para decomposição de compostos organicos." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/265273.

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Orientador: Rodnei Bertazzoli<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia Mecânica<br>Made available in DSpace on 2018-08-24T00:35:31Z (GMT). No. of bitstreams: 1 Figueiredo_RaulSebastiao_D.pdf: 4040065 bytes, checksum: 3400db86cd1264a10105354e1cc73250 (MD5) Previous issue date: 2013<br>Resumo: Este trabalho investiga o desempenho do chumbo anodizado e de uma mistura de óxidos de chumbo / estanho para uso em processos de eletro-oxidação. Os eletrodos foram preparados por anodização do chumbo e ligas de chumbo/estanho previamente laminados na forma de plac

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Fruhwirth, Grant. "Minor tranquilziers [sic] and the Valium epidemic prescription drug use and abuse in the United States, 1906-1979 /." Pullman, Wash. : Washington State University, 2010. http://www.dissertations.wsu.edu/Thesis/Spring2010/g_fruhwirth_042310.pdf.

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Li, Nan, and 李楠. "The influence of partial hepatectomy on desmethyldiazepam formation and elimination after diazepam infusion in Chinese." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31245687.

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LOVICHI, NICOLE. "Sedation pour gastroscopie : etude personnelle sur 72 cas." Toulouse 3, 1988. http://www.theses.fr/1988TOU31318.

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Kalichak, Fabiana. "EFEITOS DE RESÍDUOS DE PSICOFÁRMACOS NA ÁGUA SOBRE O DESENVOLVIMENTO INICIAL DE ZEBRAFISH." Universidade Federal de Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/9024.

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The growing and continuous use of drugs by the human population transformed the pharmacological agents in "emerging pollutants" are often found in aquatic environments. The consequences of this finding are still unclear, and little is known about the effects of these compounds on the environment and the health of exposed species. The excretion of these components still in its active form and the improper disposal thereof are among the main causes of environmental contamination. The use of embryos and larvae of zebrafish (Danio rerio) as an experimental model for toxicological testing has shown

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Sakai, Mônica. "Efeitos do diazepam sobre o crescimento do tumor ascítico de Ehrlich: envolvimento do Receptor Periférico para Benzodiazepínico (PBR) ou Proteína Translocadora (TSPO)." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/10/10133/tde-10112009-161606/.

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Os benzodiazepínicos são amplamente utilizados devido às suas propriedades ansiolíticas e sedativas mediadas pelo complexo GABAA no Sistema Nervoso Central. Porém, posteriormente foi demonstrado que os mesmos também atuam no Receptor Periférico para Benzodiazepínico (PBR), conhecido atualmente como Proteína Translocadora (TSPO), expresso tanto em células normais como também em células tumorais. O presente trabalho avaliou os efeitos in vivo da administração de diazepam sobre o crescimento do tumor ascítico de Ehrlich em camundongos e o envolvimento da TSPO mediando este efeito. Mais especifica

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Abreu, Murilo Sander de. "DIAZEPAM E FLUOXETINA INIBEM A RESPOSTA DE ESTRESSE EM ZEBRAFISH (Danio rerio)." Universidade Federal de Santa Maria, 2014. http://repositorio.ufsm.br/handle/1/9009.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The presence of pharmaceuticals in the aquatic environment has long been reported for some years in various studies. However, the impact of drugs on organisms present in aquatic ecosystems is still poorly known. Thus, we investigated the effects of acute exposure to diazepam or fluoxetine on the response to acute stress in zebrafish (Danio rerio). Fish were exposed to drugs for 15 minutes and, after this period, the group designated time 0 was collected; the other groups were subjected to a stimulus of stress, which consisted in pe

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SILVEIRA, Alberto Thalison. "Influência do diazepam nos níveis dos bioindicadores de exposição ocupacional ao tolueno." Universidade Federal de Alfenas, 2016. https://bdtd.unifal-mg.edu.br:8443/handle/tede/785.

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O tolueno (TOL) é um hidrocarboneto aromático amplamente utilizado em colas, tintas, detergentes, corantes, gasolina, solventes para tintas e produtos farmacêuticos. A exposição ao TOL pode ocorrer através da via inalatória e dérmica, no local de trabalho ou como droga de abuso. A literatura tem relatado a influência de alguns fármacos, como o etanol e o fenobarbital, na cinética de biotransformação do TOL devido interações no citocromo P450 (CYP). Os benzodiazepínicos (BZD) são fármacos amplamente utilizados na prática clínica e não há, até o presente momento, informações sobre a sua influênc

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Westergren, Emma. "Intranasal midazolam som anfallskupering vid epileptiska anfall : En jämförelse med rektal diazepam." Thesis, Umeå universitet, Institutionen för integrativ medicinsk biologi (IMB), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-173211.

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Overturf, Carmen L. "Investigation of the Pharmacokinetics of Diazepam in Juvenile Channel Catfish (Ictalurus Punctatus)." Thesis, University of North Texas, 2013. https://digital.library.unt.edu/ark:/67531/metadc407799/.

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The presence of pharmaceuticals in the environment is becoming an increasing regulatory and scientific concern. Thus, the metabolic profile and bioconcentration potential of diazepam, a model benzodiazepine, were examined, as well as effects on the endocrine system in channel catfish. Through the use of specific and non-specific cytochrome P450 (CYP450) inhibitors, it was determined that CYP3A-like enzymes may play a role in the biotransformation of diazepam into temazepam; however, the isoform(s) required for the formation of other metabolites is still unknown. Overall, only around 7-8% of di

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Fillion, Alain. "Anesthesie generale pour laryngoscopie en suspension : interet de l'association etomidate-diazepam-fentanyl." Lyon 1, 1989. http://www.theses.fr/1989LYO1M027.

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