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Journal articles on the topic 'Diazocan'

Author: Grafiati

Published: 4 June 2021

Last updated: 9 February 2022

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1

Matheny, Jonathon P., Pavel M. Yamanushkin, Peter A. Petillo, and Michael Rubin. "Facile assembly of 1,5-diazocan-2-ones via cyclization of tethered sulfonamides to cyclopropenes." RSC Advances 10, no. 72 (2020): 44183–90. http://dx.doi.org/10.1039/d0ra09014j.

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The sulfonamide moiety was evaluated as an activating and stabilizing functional group in the metal templated strain release-driven intramolecular nucleophilic addition of amines to cyclopropenes to generate 1,5-diazocan-2-ones.

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2

Oppong, Kofi A., Christopher D. Ellis, Michael C. Laufersweiler, Steven V. O’Neil, Yili Wang, David L. Soper, Mark W. Baize, et al. "Discovery of novel conformationally restricted diazocan peptidomimetics as inhibitors of interleukin-1β synthesis." Bioorganic & Medicinal Chemistry Letters 15, no. 19 (October 2005): 4291–94. http://dx.doi.org/10.1016/j.bmcl.2005.06.050.

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3

Aversaw, M. C., P. Bonaccorsi, P. Giannetto, B. Beagley, D. A. Leigh, R. Pritchard, and A. M. Truscello. "The crystal structure of 1,5-bis(3,5-dimethyl-2-hydroxybenzyl)-1,5-diazocan-2,6-dione." Journal of Heterocyclic Chemistry 29, no. 2 (March 1992): 317–20. http://dx.doi.org/10.1002/jhet.5570290207.

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4

James, Thomas, Paul MacLellan, George M. Burslem, Iain Simpson, J. Andrew Grant, Stuart Warriner, Visuvanathar Sridharan, and Adam Nelson. "A modular lead-oriented synthesis of diverse piperazine, 1,4-diazepane and 1,5-diazocane scaffolds." Org. Biomol. Chem. 12, no. 16 (2014): 2584–91. http://dx.doi.org/10.1039/c3ob42512f.

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A modular synthetic approach is described in which combinations of cyclic sulfamidate and hydroxy sulfonamide building blocks may be converted into piperazine, 1,4-diazepine and 1,5-diazocane scaffolds.

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5

Rapelli, Chandrashekhar, Balasubramanian Sridhar, and B. V. Subba Reddy. "Correction: Tandem Prins cyclization for the synthesis of indole fused spiro-1,4-diazocane scaffolds." Organic & Biomolecular Chemistry 18, no. 36 (2020): 7224. http://dx.doi.org/10.1039/d0ob90122a.

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Correction for ‘Tandem Prins cyclization for the synthesis of indole fused spiro-1,4-diazocane scaffolds’ by Chandrashekhar Rapelli et al., Org. Biomol. Chem., 2020, 18, 6710–6715, DOI: 10.1039/D0OB01384F.

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6

Bieszczad, Bartosz, Damian Garbicz, Damian Trzybiński, Damian Mielecki, Krzysztof Woźniak, Elżbieta Grzesiuk, and Adam Mieczkowski. "Unsymmetrically Substituted Dibenzo[b,f][1,5]-diazocine-6,12(5H,11H)dione—A Convenient Scaffold for Bioactive Molecule Design." Molecules 25, no. 4 (February 18, 2020): 906. http://dx.doi.org/10.3390/molecules25040906.

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A novel approach for the synthesis of unsymmetrically substituted dibenzo[b,f][1,5]diazocine-6,12(5H,11H)diones has been developed. This facile three-step method uses variously substituted 1H-benzo[d][1,3]oxazine-2,4-diones (isatoic anhydrides) and 2-aminobenzoic acids as a starting materials. The obtained products were further transformed into N-alkyl-, N-acetyl- and dithio analogues. Developed procedures allowed the synthesis of unsymmetrical dibenzo[b,f][1,5]diazocine-6,12(5H,11H)diones and three novel heterocyclic scaffolds: benzo[b]naphtho[2,3-f][1,5]diazocine-6,14(5H,13H)dione, pyrido[3,2-c][1,5]benzodiazocine-5,11(6H,12H)-dione and pyrazino[3,2-c][1,5]benzodiazocine-6,12(5H,11H)dione. For 11 of the compounds crystal structures were obtained. The preliminary cytotoxic effect against two cancer (HeLa, U87) and two normal lines (HEK293, EUFA30) as well as antibacterial activity were determined. The obtained dibenzo[b,f][1,5]diazocine(5H,11H)6,12-dione framework could serve as a privileged structure for the drug design and development.

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7

Muthukrishnan, Isravel, Muthu Karuppasamy, B. S. Vachan, Diksha Rajput, Nagarajan Subbiah, C. Uma Maheswari, and Vellaisamy Sridharan. "Chemodivergent synthesis of functionalized methanodibenzo[b,f][1,5]diazocin-13-ylmethanones and tetrahydroquinolines via solvent-dependent AB2 and A2B2 multicomponent annulation reactions." Organic Chemistry Frontiers 7, no. 13 (2020): 1616–25. http://dx.doi.org/10.1039/d0qo00449a.

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A solvent-dependent chemodivergent approach was developed for the synthesis of 6,12-methanodibenzo[b,f][1,5]diazocin-13-ylmethanones and 2,3,4-trisubstituted 1,2,3,4-tetrahydroquinolines involving two distinct AB₂ and A₂B₂ multicomponent processes.

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8

Rapelli, Chandrashekhar, Balasubramanian Sridhar, and B. V. Subba Reddy. "Tandem Prins cyclization for the synthesis of indole fused spiro-1,4-diazocane scaffolds." Organic & Biomolecular Chemistry 18, no. 34 (2020): 6710–15. http://dx.doi.org/10.1039/d0ob01384f.

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A tandem Prins strategy has been developed for the first time to produce a novel class of spiro-1,4-diazocane derivatives by the condensation of indole tethered γ-hydroxyolefin with aldehydes using BF₃·OEt₂ at −40 °C in dichloromethane.

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9

Schnieders, Christoph, Walter Huber, Johann Lex, and Klaus Müllen. "1,5-Diazocine." Angewandte Chemie 97, no. 7 (July 1985): 579–80. http://dx.doi.org/10.1002/ange.19850970716.

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10

Bieszczad, Bartosz, Damian Garbicz, Damian Trzybiński, Marta K. Dudek, Krzysztof Woźniak, Elżbieta Grzesiuk, and Adam Mieczkowski. "Unsymmetrically-Substituted 5,12-dihydrodibenzo[b,f][1,4]diazocine-6,11-dione Scaffold—A Useful Tool for Bioactive Molecules Design." Molecules 25, no. 12 (June 20, 2020): 2855. http://dx.doi.org/10.3390/molecules25122855.

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Unsymmetrically N-substituted and N,N’-disubstituted 5,12-dihydrodibenzo [b,f][1,4]diazocine-6,11-diones were synthesized in the new protocol. The desired modifications of the dibenzodiazocine scaffold were introduced at the stages of proper selection of building blocks as well as post-cyclization modifications with alkylation or acylation agents, expanding the structural diversity and possible applications of synthesized molecules. The extension of developed method resulted in the synthesis of novel: tricyclic 5,10-dihydrobenzo[b]thieno[3,4-f][1,4]diazocine-4,11-dione scaffold and fused pentacyclic framework possessing two benzodiazocine rings within its structure. Additionally, the unprecedented rearrangement of 5,12-dihydrodibenzo[b,f][1,4]diazocine-6,11-diones to 2-(2-aminophenyl)isoindoline-1,3-diones was observed under the basic conditions in the presence of sodium hydride for secondary dilactams. The structures of nine synthesized products have been established by single-crystal X-ray diffraction analysis. Detailed crystallographic analysis of the investigated tri- and pentacyclic systems has shed more light on their structural features. One cell line derived from non-cancerous cells (EUFA30—human fibroblasts) and three tumor cells (U87—human primary glioblastoma, HeLa—cervix adenocarcinoma, BICR18—laryngeal squamous cell carcinoma) were used to determine the cytotoxic effect of the newly synthesized compounds. Although these compounds showed a relatively weak cytotoxic effect, the framework obtained for 5,12-dihydrodibenzo[b,f][1,4]diazocine-6,11-dione could serve as a convenient privilege structure for the design and development of novel bioactive molecules suitable for drug design, development and optimization programs.

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11

Matheny, J. P., A. V. Aksenov, and M. Rubin. "Synthesis of 1,5-diazocin-2-ones." Russian Chemical Bulletin 70, no. 6 (June 2021): 1046–66. http://dx.doi.org/10.1007/s11172-021-3184-5.

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12

Li, Zhenghua, Yaping Zhao, Guilong Tian, Yi He, Gonghua Song, Luc Van Meervelt, and Erik V. Van der Eycken. "Synthesis of novel imidazole-based triheterocycles via a domino Ugi/Michael reaction and silver-catalyzed heteroannulation." RSC Advances 6, no. 105 (2016): 103601–5. http://dx.doi.org/10.1039/c6ra23180b.

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13

Eremeev, A. V., I. P. Piskunova, and R. S. �l'kinson. "New diazocine synthesis." Chemistry of Heterocyclic Compounds 21, no. 6 (June 1985): 707. http://dx.doi.org/10.1007/bf00515081.

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14

Preußke, Nils, Widukind Moormann, Katrin Bamberg, Matthias Lipfert, Rainer Herges, and Frank D. Sönnichsen. "Visible-light-driven photocontrol of the Trp-cage protein fold by a diazocine cross-linker." Organic & Biomolecular Chemistry 18, no. 14 (2020): 2650–60. http://dx.doi.org/10.1039/c9ob02442e.

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15

Moormann, Widukind, Daniel Langbehn, and Rainer Herges. "Solvent-Free Synthesis of Diazocine." Synthesis 49, no. 15 (July 11, 2017): 3471–75. http://dx.doi.org/10.1055/s-0036-1590685.

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A convenient two-step synthesis of diazocine starting from 2-nitrotoluene is described. The first step, the oxidative dimerization of 2-nitrotoluene, is improved to 95% yield. The second step, the reductive azo cyclization, is performed as a solvent-free reaction with lead powder in a ball mill (51% yield). As a reference, the previously described azo cyclization with Zn/Ba(OH)2 is investigated in detail. The results explain why in previous experiments the yields are low and extremely dependent on the reaction conditions. In view of potential applications in photopharmacology, we checked the stability under reducing conditions. Diazocine does not react with glutathione, indicating intracellular stability.

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16

Heintze, Linda, Dorian Schmidt, Theo Rodat, Lydia Witt, Julia Ewert, Malte Kriegs, Rainer Herges, and Christian Peifer. "Photoswitchable Azo- and Diazocine-Functionalized Derivatives of the VEGFR-2 Inhibitor Axitinib." International Journal of Molecular Sciences 21, no. 23 (November 25, 2020): 8961. http://dx.doi.org/10.3390/ijms21238961.

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In this study, we aimed at the application of the concept of photopharmacology to the approved vascular endothelial growth factor receptor (VEGFR)-2 kinase inhibitor axitinib. In a previous study, we found out that the photoisomerization of axitinib’s stilbene-like double bond is unidirectional in aqueous solution due to a competing irreversible [2+2]-cycloaddition. Therefore, we next set out to azologize axitinib by means of incorporating azobenzenes as well as diazocine moieties as photoresponsive elements. Conceptually, diazocines (bridged azobenzenes) show favorable photoswitching properties compared to standard azobenzenes because the thermodynamically stable Z-isomer usually is bioinactive, and back isomerization from the bioactive E-isomer occurs thermally. Here, we report on the development of different sulfur–diazocines and carbon–diazocines attached to the axitinib pharmacophore that allow switching the VEGFR-2 activity reversibly. For the best sulfur–diazocine, we could verify in a VEGFR-2 kinase assay that the Z-isomer is biologically inactive (IC50 >> 10,000 nM), while significant VEGFR-2 inhibition can be observed after irradiation with blue light (405 nm), resulting in an IC50 value of 214 nM. In summary, we could successfully develop reversibly photoswitchable kinase inhibitors that exhibit more than 40-fold differences in biological activities upon irradiation. Moreover, we demonstrate the potential advantage of diazocine photoswitches over standard azobenzenes.

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17

Zou, Yang, Jingyi Fei, Liangzhe Chen, Qingfeng Dong, and Houbin Li. "Application of Response Surface Methodology for Improving the Yield of 1,5-bis(ptoluenesulfonyl)- 3,7-Dihydroxyoctahydro-1,5-Diazocine." Current Organic Synthesis 16, no. 3 (June 17, 2019): 398–404. http://dx.doi.org/10.2174/1570179415666181113144357.

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Background: 3,3,7,7-tetrakis (difluoramino) octahydro-1,5-dinitro-1,5-diazocine (HNFX), as an important oxidizer in propellants, has received much attention due to its high density and energy. However, there are many difficulties that need to be solved, such as complex synthetic processes, low product yield, high cost of raw materials and complicated purification. In the synthesis of HNFX, the intermediate named 1,5-bis (p-toluenesulfonyl)-3,7-dihydroxyoctahydro-1, 5-diazocine (gem-diol), is difficult to synthesize. Methods: A simple method was used to synthesize the gem-diol. This prepared gem-diol was characterized by FT-IR, 1H NMR, melting point and mass spectrometry. In order to increase the yield of gem-diol, response surface methodology (RSM) was introduced to optimize experimental conditions. Results: After the establishment of the model, the optimal conditions of synthesis were found to be 9.33h for reaction time, 6.13wt. % for the concentration of NaOH and 1.38:1 for ratio of ECH (p-toluenesulfonamide): TCA (epichlorohydrin). Under the optimal conditions, the experimental value and the predicted value of yield were 22.18% and 22.92%, respectively. Conclusion: 1,5-bis (p-toluenesulfonyl)-3,7-dihydroxyoctahydro-1,5-diazocine (gem-diol) can be synthesized using the low cost of chemical materials, including p-toluenesulfonamide, epichlorohydrin, sodium hydroxide and ethanol. Response surface methodology (RSM) is an effective method to optimize the synthesis process, thereby improving the yield of gem-diol.

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18

Löw, Roland, Talina Rusch, Fynn Röhricht, Olaf Magnussen, and Rainer Herges. "Diazocine-functionalized TATA platforms." Beilstein Journal of Organic Chemistry 15 (July 5, 2019): 1485–90. http://dx.doi.org/10.3762/bjoc.15.150.

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Recently, it has been shown that the thermochemical cis→trans isomerization of azobenzenes is accelerated by a factor of more than 1000 by electronic coupling to a gold surface via a conjugated system with 11 bonds and a distance of 14 Å. The corresponding molecular architecture consists of a platform (triazatriangulenium (TATA)) which adsorbs on the gold surface, with an acetylene spacer standing upright, like a post in the middle of the platform and the azobenzene unit mounted on top. The rate acceleration is due to a very peculiar thermal singlet–triplet–singlet mechanism mediated by bulk gold. To investigate this mechanism further and to examine scope and limitation of the “spin-switch catalysis” we now prepared analogous diazocine systems. Diazocines, in contrast to azobenzenes, are stable in the cis-configuration. Upon irradiation with light of 405 nm the cis-configuration isomerizes to the trans-form, which slowly returns back to the stable cis-isomer. To investigate the thermal trans→cis isomerization as a function of the conjugation to the metal surface, we connected the acetylene spacer in meta (weak conjugation) and in para (strong conjugation) position. Both isomers form ordered monolayers on Au(111) surfaces.

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19

Bhuiyan, M. Delower H., Paul Jensen, and Andrew C. Try. "2,8-Dimethoxy-4,10-dimethyl-1,3,7,9-tetranitro-6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine." Acta Crystallographica Section E Structure Reports Online 63, no. 11 (October 24, 2007): o4393. http://dx.doi.org/10.1107/s1600536807050945.

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In the molecule of the title compound, C19H18N6O10, the 2,8-dimethoxy-4,10-dimethyl-1,3,7,9-tetranitro analogue of Tröger's base, the diazocine bridge imparts a twist such that the two aryl rings are offset with respect to one another. The hinge angle of the molecule, measured as the dihedral angle between the two benzene rings, is 103.64 (5)°.

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20

Himah, Sofi Aliyatul, Desie Dwi Wisudanti, and Heni Fatmawati. "Effect of Soyflour (Glycine max L.) Hepatoprotector Activity on Liver MDA Level in Male Wistar Rat Induced by Diazinon." Journal of Agromedicine and Medical Sciences 4, no. 1 (February 5, 2018): 1. http://dx.doi.org/10.19184/ams.v4i1.6857.

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Diazinon is metabolized in liver becomes diazoxon, an active metabolite form that can cause free radical raisingthat leads to lipid peroxidation. The result of lipid peroxidation is MDA. Soyflour has higher isoflavones than theother processed food of Glycine max L.This isoflavones donate its electron and hydrogen atom in lipidperoxidation so it can block the lipid peroxidation. The aim of this experiment is to investigate the effect of soyflour on MDA hepar level increase of male wistar rat induced by diazinon. The sample are divided into 5 groupswhich are Kn, K(-) group induced by diazinon 40mg/kgBW, K1, K2, K3 group given with soy flour 10%, 15%, and20% orally, then induced by diazinon 40 mg/kgBW. MDA liver measured on the day 34th with MDA-TBAmethode which has pink colour and measured by spectrofotometer. Average of liver MDA levels is Kn 6,35μg/mL; K(-) 9,23 μg/mL; K1 8,85 μg/mL; K2 7,88 μg/mL; K3 7,04 μg/mL. One way ANOVA and Post hoc LSDshowed significantly different (p<0,05). Pearson correlation showed strong negative correlation. Keywords: Diazinon, Diazoxon, MDA, Soyflour, Glycine max L., antioxidant

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21

Van Meervelt, L., and P. Kong Thoo Lin. "5,8-Bis(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-1,4-dioxa-5,8-diazocane." Acta Crystallographica Section C Crystal Structure Communications 53, no. 8 (August 15, 1997): 1131–33. http://dx.doi.org/10.1107/s0108270197003806.

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22

Gyömöre, Ádám, Zoltán Kovács, Tibor Nagy, Veronika Kudar, András Szabó, and Antal Csámpai. "DNMR, DFT and preparative study on the conformation of (Z)-4,5,6,7-tetrahydropyrazolo[1,5-e]benzo[g][1,5]diazonin-8-ones and (Z)-4,5-dihydropyrazolo[1,5-d]benzo[f][1,4]diazocin-7(6H)-ones." Tetrahedron 64, no. 48 (November 2008): 10837–48. http://dx.doi.org/10.1016/j.tet.2008.09.020.

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23

MOTTEQUIN, Bernard. "An annotated catalogue of types of Silurian–Devonian brachiopod species from southern Belgium and northern France in the Royal Belgian Institute of Natural Sciences (1870–1945), with notes on those curated in other Belgian and foreign institutions." Geologica Belgica 22, no. 1-2 (2019): 47–89. http://dx.doi.org/10.20341/gb.2019.005.

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The type material of 45 Pridolian–Devonian brachiopod species, described in southern Belgium and northern France (1870–1945) and curated at the Royal Belgian Institute of Natural Sciences (Brussels), is re-investigated and illustrated in order to facilitate future taxonomic revision; such a catalogue should allow a better assessment of the brachiopod diversity during the considered time span. Furthermore, 28 other Silurian–Devonian species originally described in Belgium (1850–1950), but housed in other Belgian or foreign institutions, are also discussed. For taxonomical purposes, the lectotypes of several species are selected; the latter were described by Asselberghs (Stropheodonta couviniensis, Plethorhyncha percostata var. gdoumontensis, Athyris dorlodoti, Retzia gdoumontensis, Dielasma maillieuxi), Béclard (Orthis dorsoplicata, Orthis musischura, Rhynchonella parvula (non R. parvula Eudes-Deslongchamps)), de Ryckholt (Lingula amayana), Dewalque (Crania corneti), and Maillieux (Discina (Discina) forrierensis, Pholidostrophia extensa, Anoplia theorassensis, Schuchertella durbutensis, Streptorhynchus rahiri, Pentamerus loei). Re-investigation of the ambocoeliid Spirifer pentameroides Stainier highlighted the homonymy between Diazoma Dürkoop, 1970 (Brachiopoda) and Diazoma Lamarck, 1816 (Tunicata); the former genus must be rejected and replaced by a valid synonym, namely Kelusia Mamedov, 1978.

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24

Breydak, O. A. "Experimental evaluation of gonadotoxical action of diazolin." Medicni perspektivi (Medical perspectives) 21, no. 4 (December 22, 2016): 15–18. http://dx.doi.org/10.26641/2307-0404.2016.4.90022.

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25

Kudo, Yoshiyuki, Teruyoshi Kimura, and Shuichi Hamada. "The Pyrolysis of 1,2,3,4,6,7-Hexathia-5,8-diazocine." Bulletin of the Chemical Society of Japan 63, no. 1 (January 1990): 235–40. http://dx.doi.org/10.1246/bcsj.63.235.

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26

Liu, Yanan, Zuwei Song, Libin Gao, and Jianzhong Li. "An Optical pH Sensor Based on Diazocine." ChemistrySelect 2, no. 26 (September 11, 2017): 7956–60. http://dx.doi.org/10.1002/slct.201700983.

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27

Ryu, Jaemin, Min-Jin Jo, Hyocheol Jung, Hayoon Lee, Donghee Shin, Miyeon Park, Kwang-Yol Kay, and Jongwook Park. "Synthesis and electroluminescent properties of diazocine derivatives." Molecular Crystals and Liquid Crystals 651, no. 1 (July 3, 2017): 77–84. http://dx.doi.org/10.1080/09273948.2017.1338890.

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28

Yang, Bingchuan, Guodong Shen, Xianqiang Huang, and Rutao Liu. "Design and Synthesis of a Novel Banana-Shaped Functional Molecule via Double Cross-Coupling." Molecules 24, no. 4 (February 15, 2019): 698. http://dx.doi.org/10.3390/molecules24040698.

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A novel banana-shaped molecule using 2,8-Dimethyl-6H,12H-5,11-methanodibenzo [b,f] [1,5]diazocine (Tröger’s base) as bent-core was synthesized via double Carbon-Carbon cross-coupling reaction. The double Sonogashira cross-coupling reaction was optimized by using Pd(PPh3)2Cl2 as catalyst, CuI as cocatalyst and diisopropylamine as base in place of triethylamine. The structure of this compound was confirmed by 1H-NMR, 13C-NMR, Fourier transform infrared (FT-IR) spectroscopy and mass spectrometry.

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29

Cai, Xiao-Qing, Ai-Li Liu, Xiao-Wei Yan, Ke-Jian Zhao, Mei-Rong Li, and Xiao-Nuan Xie. "Crystal structure of N,N-ditosyldibenzo-1,5-diazocane-2,6-dione, C28H22N2O6S2." Zeitschrift für Kristallographie - New Crystal Structures 224, no. 2 (June 2009): 224–26. http://dx.doi.org/10.1524/ncrs.2009.0100.

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30

Cai, Xiao-Qing, Ai-Li Liu, Xiao-Wei Yan, Ke-Jian Zhao, Mei-Rong Li, and Xiao-Nuan Xie. "Crystal structure of N,N-ditosyldibenzo-1,5-diazocane-2,6-dione, C28H22N2O6S2." Zeitschrift für Kristallographie - New Crystal Structures 224, no. 1-4 (April 2009): 224. http://dx.doi.org/10.1524/ncrs.2009.224.14.224.

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31

Cai, Xiao-Qing, Ai-Li Liu, Xiao-Wei Yan, Ke-Jian Zhao, Mei-Rong Li, and Xiao-Nuan Xie. "Crystal structure of N,N-ditosyldibenzo-1,5-diazocane-2,6-dione, C28H22N2O6S2." Zeitschrift für Kristallographie - New Crystal Structures 224, no. 1-4 (April 2009): 234–36. http://dx.doi.org/10.1524/ncrs.2009.224.14.234.

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32

Faroughi, Masoud, Paul Jensen, and Andrew C. Try. "6H,12H-5,11-Methanodibenzo[b,f][1,5]diazocine." Acta Crystallographica Section E Structure Reports Online 63, no. 7 (June 8, 2007): o3111. http://dx.doi.org/10.1107/s160053680702661x.

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33

Faroughi, Masoud, Andrew C. Try, and Peter Turner. "6H,12H-5,11-Ethanodibenzo[b,f][1,5]diazocine." Acta Crystallographica Section E Structure Reports Online 64, no. 2 (January 16, 2008): o458. http://dx.doi.org/10.1107/s1600536808000883.

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34

Kim, Taemin, Seokwoo Kang, Hyocheol Jung, Hayoon Lee, Donghee Shin, Miyeon Park, Kwang-Yol Kay, and Jongwook Park. "Synthesis and electroluminescent properties of new diazocine derivatives." Molecular Crystals and Liquid Crystals 662, no. 1 (February 11, 2018): 102–8. http://dx.doi.org/10.1080/15421406.2018.1466521.

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35

Collier, W., LS Curtis, NF Curtis, and IJ Pomer. "Kinetics of Acid-Hydrolysis of Nickel(II) and Copper(II) Compounds With the Cyclic Diamines 1,5-Diazocane and 4,4-Dimethyl-7-(5,5,7-trimethyl-1,4-diazepan-1-Yl)-5-azaheptan-2-ol." Australian Journal of Chemistry 42, no. 9 (1989): 1611. http://dx.doi.org/10.1071/ch9891611.

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The kinetics of acid-promoted hydrolysis reactions of nickel(II) and copper(ll) complexes of the cyclic diamines 1,5-diazocane ( daco ) and 4,4-dimethyl-7-(5,5,7-trimethyl-1,4-diazepan-1-yl)-5-azaheptan-2-ol (pyaz) in NaCl/HCl media ([Cl-] = 2 mol dm-3) are reported. For [Ni( daco )2]2+, beyond small [H+], an acid-limited rate constant of 2.0×10-5 S-l, involving dissociation of the first daco ligand, and for [Cu( daco )2]2+ a similarly acid-limited rate constant of 1.5×10-2 s-l, involving dissociation of the second daco ligand, were measured at 50°C. For [Ni( pyaz )]2+ and [Cu ( pyaz )2+ the rates of the hydrolysis reactions are again acid-limited, effectively independent of acid with rate constant of 1.0×10-2 s-1 for [Ni( pyaz )]2+ while for [Cu( pyaz )]2+ the rate follows the expression kobs , = 6.0×10-2[H+]/(l+4.6[H+]) S-l, both measured at 25°C.

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36

Wakamatsu, Hideaki, Yuichi Yoshimura, Yoshimi Sasaki, Masatoshi Kawahata, and Kentaro Yamaguchi. "Synthesis of Various Heterocycles Having a Dienamide Moiety by Ring-Closing Metathesis of Ene-ynamides." Synthesis 50, no. 17 (May 30, 2018): 3467–86. http://dx.doi.org/10.1055/s-0037-1609857.

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Ring-closing metathesis (RCM) of ynamides, having alkene substituents of various lengths on the side chain, was demonstrated using the second-generation Grubbs catalyst. When the reaction of ene-ynamides was carried out in the presence of 5 mol% of the catalyst, RCM proceeded smoothly to give quinoline or isoquinoline derivatives having a dienamide unit in good yields. Furthermore, RCM of ene-ynamides, having one more carbon on the side chain, proceeded smoothly to provide seven-membered heterocycles having a dienamide component. Similarly, eight-membered heterocycles, diazocine and benzodiazocine, were also synthesized by RCM of ene-ynamides in good yields.

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37

Vande Velde, Christophe M. L., Benoît Tylleman, Matthias Zeller, and Sergey Sergeyev. "Structures of alkyl-substituted Tröger's base derivatives illustrate the importance of Z′ for packing in the absence of strong crystal synthons." Acta Crystallographica Section B Structural Science 66, no. 4 (July 12, 2010): 472–81. http://dx.doi.org/10.1107/s0108768110021981.

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Crystal structures of Tröger's base (5,11-methano-2,8-dimethyl-5,6,11,12-tetrahydrodibenzo[b,f][1,5]diazocine) analogues with the methyl groups replaced by ethyl, iso-propyl and tert-butyl groups were studied. The incidence of Z′ > 1 structures increases to rather conspicuous levels. The reasons behind this trend are expanded upon, and a possible explanation is given in the flexibility of the alkyl substituents and van der Waals stabilization. In combination these effects allow for an additional stabilization of the packing by small changes in the molecular conformations, thus expanding the size of the asymmetric unit.

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38

VAN MEERVELT, L., and P. KONG THOO LIN. "ChemInform Abstract: 5,8-Bis(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-1,4-dioxa-5,8- diazocane (V)." ChemInform 28, no. 48 (August 2, 2010): no. http://dx.doi.org/10.1002/chin.199748206.

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39

Kuzminov, B. P., T. S. Zazuljak, V. A. Turkina, A. A. Breydak, and T. A. Alechina. "JUSTIFICATION OF DIAZOLINE PERMISSIBLE LEVELS IN OCCUPATIONAL AIR IN CHEMICAL AND PHARMACEUTICAL INDUSTRIES." Toxicological Review, no. 1 (February 28, 2016): 18–20. http://dx.doi.org/10.36946/0869-7922-2016-1-18-20.

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The toxicological assessment of diazoline, the first- generation antihistaminic preparation, was carried out together with justification of the hygiene standard for permissible content ( (Tentative Safe Exposure LevelTSEL) of occupational air in production premises. It was found out that according to acute oral toxicity criterion, Diazoline refers to low hazardous substances. In the clinical picture of acute and sub-chronic intoxication, CNS involvement prevails. Diazolin has a weak local irritant effect in case of contact with mucous membranes, shows a strong cumulative activity. In case of intracutaneous sensitization, it influences indicators of the cellular and humoral component of innate and acquired immunity. TSEL of diazoline in occupational air is 1.0 mg/m .

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40

Wallis, J. D. "The first structure of a benzo[b][1,4]diazocine." Acta Crystallographica Section C Crystal Structure Communications 48, no. 5 (May 15, 1992): 897–99. http://dx.doi.org/10.1107/s0108270191012337.

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41

Gregory, Mark A., Bolong Zhang, Andrew J. Tilley, Tamika Scheerlinck, Jonathan M. White, and Wallace W. H. Wong. "Amine-Substituted Diazocine Derivatives - Synthesis, Structure, and Photophysical Properties." Helvetica Chimica Acta 101, no. 11 (November 2018): e1800146. http://dx.doi.org/10.1002/hlca.201800146.

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42

Jung, Hyocheol, Hayoon Lee, Jaemin Ryu, Donghee Shin, Miyeon Park, Kwang-Yol Kay, and Jongwook Park. "Synthesis and Electroluminescent Properties of New Dibenzo-Diazocine Derivatives." Journal of Nanoscience and Nanotechnology 18, no. 3 (March 1, 2018): 2171–74. http://dx.doi.org/10.1166/jnn.2018.14951.

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43

Lee, Hayoon, Seokwoo Kang, Cheulwoo Ann, Donghee Shin, Miyeon Park, Kwang-Yol Kay, and Jongwook Park. "New anthracene derivatives including diazocine for blue emitting materials." Molecular Crystals and Liquid Crystals 651, no. 1 (July 3, 2017): 71–76. http://dx.doi.org/10.1080/09273948.2017.1338888.

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44

Fan, Xiao-Wei, Xue-Hai Ju, and He-Ming Xiao. "Density functional theory study of piperidine and diazocine compounds." Journal of Hazardous Materials 156, no. 1-3 (August 2008): 342–47. http://dx.doi.org/10.1016/j.jhazmat.2007.12.024.

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45

Ewing, D. F., G. Goethals, G. Mackenzie, P. Martin, G. Ronco, L. Vanbaelinghem, and P. Villa. "Entry to the 2,5-Epoxyimidazo[1,5-a][1,3]Diazocine and 5,8-Epoxy[1,2,3]Triazolo[1,5-a][1,3]Diazocine Systems : Novel Reversed Cyclonucleoside Analogues." Journal of Carbohydrate Chemistry 18, no. 4 (January 1999): 441–50. http://dx.doi.org/10.1080/07328309908544008.

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46

Xu, Qiang, Guo Qiang Li, and Jiang Ping Meng. "Crystal structure of [2,2'-(1,5-diazocane-1,5-diyl)diethanamine-κ4N]- nickel(II) diperchlorate, C10H24Cl2N4NiO8." Zeitschrift für Kristallographie - New Crystal Structures 230, no. 3 (September 1, 2015): 231–32. http://dx.doi.org/10.1515/ncrs-2014-9148.

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47

Shvydenko, Tetiana, Kostiantyn Nazarenko, Kostiantyn Shvydenko, Sergey Boron, Oleksii Gutov, Andrey Tolmachev, and Aleksandr Kostyuk. "Reduction of imidazolium salts – An approach to diazocines and diazocanes." Tetrahedron 73, no. 49 (December 2017): 6942–53. http://dx.doi.org/10.1016/j.tet.2017.10.053.

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48

Tang, Le, Jing Ren, Yuchi Ma, Xin Wang, Lin Chen, Jingkang Shen, Yue-Lei Chen, and Bing Xiong. "Formation of 1,3-diazocine by palladium catalyzed C–H arylation." Tetrahedron Letters 57, no. 21 (May 2016): 2311–14. http://dx.doi.org/10.1016/j.tetlet.2016.04.050.

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49

Faroughi, Masoud, Andrew C. Try, and Peter Turner. "2,8-Dichloro-6H,12H-5,11-ethanodibenzo[b,f][1,5]diazocine." Acta Crystallographica Section E Structure Reports Online 64, no. 1 (December 6, 2007): o39. http://dx.doi.org/10.1107/s1600536807062642.

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50

Yuan, Chun-Xue. "2,8-Dimesitylboranyl-6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine." Acta Crystallographica Section E Structure Reports Online 68, no. 1 (December 3, 2011): o22. http://dx.doi.org/10.1107/s1600536811051051.

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