Relevant bibliographies by topics / Dibenzalacetone / Journal articles
To see the other types of publications on this topic, follow the link: Dibenzalacetone.

Journal articles on the topic 'Dibenzalacetone'

Author: Grafiati
Published: 5 June 2025
Last updated: 15 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 47 journal articles for your research on the topic 'Dibenzalacetone.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Purwaningsih, Yuliana, Erwin Indriyanti, Mighfar Syukur, and Dyan Wigati. "Synthesis of Dibenzalacetone using Sonochemistry and Its Antibacterial Activity Against Escherichia coli." JKPK (Jurnal Kimia dan Pendidikan Kimia) 8, no. 3 (2023): 297. http://dx.doi.org/10.20961/jkpk.v8i3.65172.

Full text
Abstract:
The synthesis of dibenzalacetone, a ketone compound with potential antibacterial properties, especially against <em>Escherichia coli</em>, has typically involved time-consuming methods. This study adopts sonochemistry, an increasingly popular technique recognized for its efficiency and quick yield. The aim is to synthesize dibenzalacetone using the sonochemical method and evaluate its antibacterial efficacy against <em>E. coli</em>. The synthesis process includes a cross-aldol condensation reaction between acetone and benzaldehyde, catalyzed by NaOH, conducted in an ultrasonic bath at 35 °C for 1-5 minutes. The optimal synthesis condition, achieved in 4 minutes, resulted in a 76.56% yield of dibenzalacetone, characterized as a bright yellow solid with a melting point of 111-114°C. Techniques such as FT-IR, GC-MS, 1H-NMR, and 13C-NMR spectrometry were employed for structural characterization. The FTIR analysis revealed various functional groups, including C=O ketone, C=C aromatic, and C-H aromatic. GC-MS data confirmed the molecular weight of dibenzalacetone at m/z 234.1. Furthermore, <sup>1</sup>H-NMR and <sup>13</sup>C-NMR analyses provided detailed insights into the compound's chemical shifts and structural groups, affirming the successful synthesis of dibenzalacetone. The antibacterial activity of dibenzalacetone against <em>E. coli</em> was tested at concentrations ranging from 5% to 20%. Notably, at a 15% concentration, dibenzalacetone exhibited antibacterial activity comparable to amoxicillin. These findings suggest that dibenzalacetone, efficiently synthesized via sonochemistry, not only achieves a high yield but also has potential as an antibacterial agent against <em>E. coli</em>. This research highlights the efficacy of sonochemistry for the rapid and effective synthesis of compounds with significant medical applications.
APA, Harvard, Vancouver, ISO, and other styles
2

Ariefin, Mokhamat, and Rokiy Alfanaar. "Immobilization of Dibenzalacetone on TiO2 Surface and its Potential as Anti-UV Material." CHEMPUBLISH JOURNAL 7, no. 1 (2023): 1–7. http://dx.doi.org/10.22437/chp.v7i1.26109.

Full text
Abstract:
Sunlight has been known to provide many benefits to human life. However, behind these benefits, there are some negative effects along with the destruction of the ozone layer and the environment on earth. One of them is exposure to ultraviolet (UV) rays which can cause several diseases such as skin cancer. One way to overcome this is by using sunscreen substances. In this study, dibenzalacetone immobilization on TiO2 has been carried out for anti-UV applications. Based on the test results using UV-Vis spectrometry, TiO2, and dibenzalacetone both have anti-UV properties with maximum peaks at wavelengths of 335 nm and 346 nm with absorbance values of 0.871 and 1.197. Immobilization of TiO2 with dibenzalacetone gives an absorbance with a value of 1.221 at a wavelength of 329. These results indicate that TiO2 immobilization with dibenzalacetone provides better anti-UV A properties than TiO2 because of the higher absorbance value.
APA, Harvard, Vancouver, ISO, and other styles
3

Jessica, Maria Anabella, Tutuk Budiati, and Caroline. "Pengaruh Gugus Hidroksi pada Sintesis Senyawa 4,4’-Dihidroksibenzalaseton dan Aktivitasnya sebagai Antioksidan." Jurnal Farmasi Sains dan Terapan 12, no. 1 (2025): 54–63. https://doi.org/10.33508/jfst.v12i1.7201.

Full text
Abstract:
Dibenzalacetone and their derivatives, , 4,4’ dihydroxydibenzalacetone are curcumin analogs that have antioxidant activity. The effect of hydroxyl group on the synthesis reaction is proven by comparing the synthesis results yield of dibenzalacetone with 4,4’-dihydroxydibenzalacetone. Both compounds are synthesized through the Claisen-Schmidt condensation reaction using sodium hydroxide as the catalyst. The synthesis results were tested for purity by melting point tests and thin layer chromatography, and structure identification tests were carried out using infrared spectrophotometry. The results of the study showed that the percentage yield of dibenzalacetone was greater than 4,4’-dihydroxydibenzalacetone, which was 67.29% and 24.51%, respectively. The presence of hydroxyl groups can increase the density of the benzene ring and facilitate the reaction of the carbonyl group of 4-hydroxybenzaldehyde, including the Cannizaro reaction. The Cannizaro reaction can occur in aldehyde compounds without alpha hydrogen, such as benzaldehyde, where some of the aldehyde will undergo oxidation and some will undergo reduction. As a result, the amount of aldehyde that reacts with acetone decreases so that the yield obtained is lessthan dibenzalacetone. Antioxidant testing was carried out using the DPPH method and expressed as an IC50 value, then compared with curcumin and vitamin C. Although it does not show greater antioxidant activity than curcumin or vitamin C, the presence of hydroxyl groups in 4,4' dihydroxydibenzalacetone can increase antioxidant activity compared to dibenzalacetone which does not have a hydroxyl group. This is proven by the IC50 value of the compound 4,4'-dihydroxydibenzalacetone which is lower than dibenzalacetone, which is 3.9588 mM and 66.5503 mM, respectively.
APA, Harvard, Vancouver, ISO, and other styles
4

Raymond Compton Jagessar and Coco Dawn Barthod. "Antimicrobial activity of Dibenzalacetone (C17H14O)." World Journal of Advanced Pharmaceutical and Medical Research 4, no. 1 (2023): 020–29. http://dx.doi.org/10.53346/wjapmr.2023.4.1.0012.

Full text
Abstract:
Dibenzalacetone was synthesized via the base catalysed condensation reaction between acetone and benzaldehyde. This study was done to evaluate the antimicrobial activity of the synthesized compound dibenzalacetone (C17H14O) against four human pathogenic microorganisms: Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginiosa and the fungus Candida albicans. The highest area of zone of inhibition of 68.23 mm2 was induced against Candida albicans and the lowest AZOI of 37.55 mm2 was induced against E.coli. Staphylococcus aureus was totally resistant to the drug, in that zero zone of inhibition was induced against dibenzalacetone. The order of antimicrobial potency followed the sequence: Candida albicans > Klebsiella pneumoniae > Pseudomonas aeruginosa > Staphylococcus aureus. However, its antimicrobial potency was lowered than that of standard synthetic drug, Ampicillin and Ketoconazole.
APA, Harvard, Vancouver, ISO, and other styles
5

Hull, Leslie A. "The Dibenzalacetone Reaction Revisited." Journal of Chemical Education 78, no. 2 (2001): 226. http://dx.doi.org/10.1021/ed078p226.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Vasconcelos, Vitória M. R., Bruna B. Postacchini, Hélcio S. dos Santos та ін. "Red-shifted optical absorption induced by donor–acceptor–donor π-extended dibenzalacetone derivatives". RSC Advances 15, № 4 (2025): 2416–29. https://doi.org/10.1039/d4ra07256a.

Full text
Abstract:
Dibenzalacetone derivatives exhibit red-shifted absorption influenced by structural modifications and solvent polarity, showing potential for applications in organic solar cells due to enhanced conjugation and optoelectronic properties.
APA, Harvard, Vancouver, ISO, and other styles
7

Godha, Neha, Shubhang Vyas, Seema Kothari, and Suresh C. Ameta. "Use of Some Metal Ferrites as Catalyst in Aldol Condensation Reaction." Asian Journal of Organic & Medicinal Chemistry 7, no. 4 (2023): 304–8. http://dx.doi.org/10.14233/ajomc.2022.ajomc-p407.

Full text
Abstract:
Two moles of benzaldehyde and one mole of acetone were condensed to afford dibenzalacetone in presence of sodium hydroxide. This aldol condensation was carried out in presence of magnetic copper ferrite, CuFe2O4, which was synthesized by hydrothermal method. Other magnetic ferrites (where M = Ni, Co, Zn and Mg) were also prepared. As-prepared metal ferrites were characterized by X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDX), scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). The copper ferrite was observed to be square shaped and particle size was 29.71 nm. The yield of product (dibenzalacetone) in presence of copper ferrite was found to be highest (90.6%). A comparative study was made with different metal ferrites as catalyst and found that the activity of metal ferrites followed the order: CuFe2O4 > ZnFe2O4 > NiFe2O4 > CoFe2O4 > MgFe2O4
APA, Harvard, Vancouver, ISO, and other styles
8

Mohammed Metwally, El Sayed Aly, Mohammed Abdel Fattah Desheesh, Doaa Mohammed Abd El-kawy Elmasry, Mahmoud Morshedy Farg, Hamada Mahmoud Youssef, and Rasha M. Elshinety. "Congenital skeletal malformations induced by lambda-cyhalothrin, dibenzalacetone and heptanone derivatives in embryos of albino mice." International Journal of Anatomy and Research 9, no. 1.3 (2021): 7912–27. http://dx.doi.org/10.16965/ijar.2021.109.

Full text
Abstract:
Background: Insecticides such as lambda-cyhalothrin(LCT), dibenzalacetone (DBA) and heptanone HD are teratogenic substances. Skeleton is one of the organs sensitive to teratogens during the period of organogenesis. Material and methods:This study was conducted on fifty adult female albino mice, divided randomly into four groups: Group I (control group, n= 5 received corn oil orally in adose of 10 mg /kg body weight), group II (LCT group, n=10 received LCT (nano 8%)10, 20 mg /kg body weight for each subgroup), group III (DBA group, n=20, received DBA (main) 10, 20 mg /kg body weight and DBA (nano 8%)) 10,20mg /kg body weight for each subgroup) and group IV (HD group, n=15, received HD (main) 10 mg /kg body weight and HD (nano 8%)) 10,50mg /kg body weight for each subgroup),The calculated treatment dissolved in 1 ml of corn oil by orogastric tube was given to the pregnant mice during the first week of pregnancy (1st, 3rd and 5th day).The delivered live and dead pups were examined externally, then double stained and prepared for skeletal examination by dissecting microscope. Results: All experimental groups showed various anomalies that can be categorized as the following: 1) presence of dead pups and resorption sites 2) macroscopic anomalies in the form of anencephaly, extended forelimb, cranioshisis, macroglossia, lowset ears, lage eye bulge, half body, amelia, internal rotation of forelimb and encephalocele. 3) skeletal anomalies by double staining of fetal skeleton showed incomplete ossification of nasal and interparietal bones, open arch of atlas, incomplete ossification of vertebrae, supernumerary ribs, wavy ribs, incomplete ossification of ribs and sternebrae, incomplete ossification of sternum, incomplete ossification of 5th metacarpal and terminal phalangal bones and incomplete ossification of tarsal , and phalangal bones. Conclusion: Lambda-cyhalothrin, dibenzalacetone and derivatives of heptanone result in numbers of congenital gross and skeletal abnormalities that indicate their teratogenic effect. KEY WORDS: Lambada, Congenital, Skeletal, Dibenzalacetone, Heptanone, Teratogenic.
APA, Harvard, Vancouver, ISO, and other styles
9

Periyasamy, Seplapatty Kalimuthu, and R. Ponmadasamy. "Cooxidation of Dibenzalacetone with Oxalic Acid by Pyrazinium Chlorochromate." International Letters of Chemistry, Physics and Astronomy 85 (December 2020): 1–14. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.85.1.

Full text
Abstract:
Oxidation of dibenzalacetone with pyrazinium chlorochromate in presence of oxalic acid has been studied at 313 K. Various reaction parameters such as effect of varying oxidant, substrate, Hydrogen ion concentration, catalyst, solvent composition, ionic strength, effect of Mn2+, effect of Al3+ and effect of temperature were studied to determine the kinetics of the reaction. Our study revealed that the reaction followed first order dependence with respect to oxidant and catalyst. The reaction followed fractional order kinetics with respect to substrate and H+. Increase in ionic strength was found to have no effect on the reaction rate and decrease in the dielectric constant of the medium decreases the reaction rate. Increase in the concentration of manganous sulphate retarded the reaction rate which confirmed the two-electron transfer involved in the mechanism. There was no possibility of free radical mechanism, which was confirmed by the addition of acrylonitrile shows no significant effect on the reaction rate indicating the non-involvement of free radical reaction.. Based on the experimental observations a mechanism and rate law has been derived. Moreover, the oxidation product was found to be chalcone epoxide, which was characterized by IR spectrum.
APA, Harvard, Vancouver, ISO, and other styles
10

Periyasamy, Seplapatty Kalimuthu, and R. Ponmadasamy. "Cooxidation of Dibenzalacetone with Oxalic Acid by Pyrazinium Chlorochromate." International Letters of Chemistry, Physics and Astronomy 85 (December 24, 2020): 1–14. http://dx.doi.org/10.56431/p-jsue79.

Full text
Abstract:
Oxidation of dibenzalacetone with pyrazinium chlorochromate in presence of oxalic acid has been studied at 313 K. Various reaction parameters such as effect of varying oxidant, substrate, Hydrogen ion concentration, catalyst, solvent composition, ionic strength, effect of Mn2+, effect of Al3+ and effect of temperature were studied to determine the kinetics of the reaction. Our study revealed that the reaction followed first order dependence with respect to oxidant and catalyst. The reaction followed fractional order kinetics with respect to substrate and H+. Increase in ionic strength was found to have no effect on the reaction rate and decrease in the dielectric constant of the medium decreases the reaction rate. Increase in the concentration of manganous sulphate retarded the reaction rate which confirmed the two-electron transfer involved in the mechanism. There was no possibility of free radical mechanism, which was confirmed by the addition of acrylonitrile shows no significant effect on the reaction rate indicating the non-involvement of free radical reaction.. Based on the experimental observations a mechanism and rate law has been derived. Moreover, the oxidation product was found to be chalcone epoxide, which was characterized by IR spectrum.
APA, Harvard, Vancouver, ISO, and other styles
11

Lynch, Hailey N., Austin H. Harnage, and Anuradha Liyana Pathiranage. "Gas Chromatography–Mass Spectrometric Analysis of Derivatives of Dibenzalacetone Aldol Products." Journal of Chemical Education 98, no. 11 (2021): 3572–79. http://dx.doi.org/10.1021/acs.jchemed.1c00595.

Full text
APA, Harvard, Vancouver, ISO, and other styles
12

Periasamy, R., R. Rajamohan, S. Kothainayaki та K. Sivakumar. "Spectral investigation and structural characterization of Dibenzalacetone: β-Cyclodextrin inclusion complex". Journal of Molecular Structure 1068 (червень 2014): 155–63. http://dx.doi.org/10.1016/j.molstruc.2014.04.004.

Full text
APA, Harvard, Vancouver, ISO, and other styles
13

Singh, Neeloo, and Indira Singh Chauhan. "MicroRNA expression profiling of dibenzalacetone (DBA) treated intracellular amastigotes of Leishmania donovani." Experimental Parasitology 193 (October 2018): 5–19. http://dx.doi.org/10.1016/j.exppara.2018.07.018.

Full text
APA, Harvard, Vancouver, ISO, and other styles
14

Albar, Hassan A., Magda A. Abdallah, Mosselhi A. N. Mosselhi, and Ahmad S. Shawali. "Regiochemistry of the cycloaddition of nitrilium N-phenylimides to dibenzalacetone: A reinvestigation." Heteroatom Chemistry 7, no. 4 (1996): 225–28. http://dx.doi.org/10.1002/(sici)1098-1071(199608)7:4<225::aid-hc2>3.0.co;2-4.

Full text
APA, Harvard, Vancouver, ISO, and other styles
15

Muthukrishnan, P., P. Prakash, K. Kavi Rasu, P. Sakthivel, and A. Muthukrishnaraj. "Charge transfer resistance of nitro substituted dibenzalacetone on mild steel against acid attack." Journal of the Indian Chemical Society 100, no. 1 (2023): 100834. http://dx.doi.org/10.1016/j.jics.2022.100834.

Full text
APA, Harvard, Vancouver, ISO, and other styles
16

Faghihi, Khalil, and Mohsen Hajibeygi. "Synthesis and properties of polyimide/silver nanocomposite containing dibenzalacetone moiety in the main chain." Journal of Saudi Chemical Society 17, no. 4 (2013): 419–23. http://dx.doi.org/10.1016/j.jscs.2011.05.005.

Full text
APA, Harvard, Vancouver, ISO, and other styles
17

ALBAR, H. A., M. A. ABDALLAH, M. A. N. MOSSELHI, and A. S. SHAWALI. "ChemInform Abstract: Regiochemistry of the Cycloaddition of Nitrilium N-Phenylimides to Dibenzalacetone: A Reinvestigation." ChemInform 28, no. 5 (2010): no. http://dx.doi.org/10.1002/chin.199705073.

Full text
APA, Harvard, Vancouver, ISO, and other styles
18

Behzad, Nasiri, and Ashouri Akram. "Highly diastereodivergent green synthesis of cyclohexanones via double Michael addition of malononitrile to Dibenzalacetone." Tetrahedron 179 (July 2025): 134637. https://doi.org/10.1016/j.tet.2025.134637.

Full text
APA, Harvard, Vancouver, ISO, and other styles
19

Ekawati, Linda, Bambang Purwono, and Muhammad Idham Darussalam Mardjan. "Synthesis N-Phenyl Pyrazoline from Dibenzalacetone and Heme Polymeration Inhibitory Activity (HPIA) Assay." Key Engineering Materials 840 (April 2020): 245–50. http://dx.doi.org/10.4028/www.scientific.net/kem.840.245.

Full text
Abstract:
The synthesis of 1,5-diphenyl-3-styryl-4,5-dihydro-1H-pyrazole (B1) and 5-(3,4-dimethoxyphenyl)-3-(3,4-dimethoxystyryl)-1-phenyl-4,5-dihydro-1H-pyrazole (B2) have been conducted from 1,5-diphenylpenta-1,4-dien-3-on (A1) and 1,5-bis(3,4-dimethoxyphenyl)penta-1,4-dien-3-one (A2). Heme polymerization inhibitory activity (HPIA) assay of the synthesized compounds has also been carried out. The first step of reaction was Claisen-Schmidt condensation of benzaldehyde derivatives and acetone using NaOH 20% and ethanol as solvent. Dibenzalacetone derivatives were reacted with phenylhydrazine using acetic acid to form N-phenylpyrazoline. The structure of products was characterized by FT-IR, GC-MS, DI-MS, 1H- and 13C-NMR The result of heme polymerization inhibitory activity assay showed that IC50 of B1 and B2 1.26 and 0.79 mM while quinine 1.26 mM. The result indicated that compound B2 was more potent as antimalarial than quinine.
APA, Harvard, Vancouver, ISO, and other styles
20

Pramod, Singh, Rawat Bipin, S. Rawat B., Joshi nee Pant Geeta, S. M. Rawat M., and C. Joshi G. "Synthesis, centrifugal chromatographic separation and fluorescence study of a 2-pyrazoline." Journal of Indian Chemical Society Vol. 91, Aug 2014 (2014): 1555–60. https://doi.org/10.5281/zenodo.5728887.

Full text
Abstract:
Department of Chemistry, H. N. B. Garhwal University, Srinagar (Garhwal)-246 174, Uttarakhand, India <em>E-mail </em>: msmrawat@gmail.com; geeta_joshi4f54@rediffmail.com Department of Physics, H. N. B. Garhwal University, Srinagar (Garhwal)-246 174, Uttarakhand, India <em>Manuscript received 20 December 2013, accepted 20 January 2014</em> The pyrazolines are well known fluorescent brightening agents and are used as chemosensors. The reaction of dibenzalacetone with hydrazine hydrate and acetic acid yielded a mixture of two products (1 and 2), purified by centrifugal chromatographic separation using chromatotron. Compound 1 was characterized as 5-phenyl-3-[(<em>E</em>)-2- phenylvinyl]-4,5-dihydro-1<em>H</em>-pyrazole-1-methylcarbaldehyde by ESI-MS, FT-IR, UV, fluorescence spectroscopy, <sup>1</sup>H NMR data and microanalysis. The fluorescence quantum yield has been determined in various solvents and ratio of excited state dipole moment to ground state dipole moment has been determined using solvatochromic method. The compound can be used as efficient fluorescent material in ultraviolet range.
APA, Harvard, Vancouver, ISO, and other styles
21

Ogasawara, Masamichi, Hisashi Ikeda, Takashi Nagano, and Tamio Hayashi. "Palladium-Catalyzed Asymmetric Synthesis of Axially Chiral Allenes: A Synergistic Effect of Dibenzalacetone on High Enantioselectivity." Journal of the American Chemical Society 123, no. 9 (2001): 2089–90. http://dx.doi.org/10.1021/ja005921o.

Full text
APA, Harvard, Vancouver, ISO, and other styles
22

Faghihi, Khalil, Mohsen Hajibeygi, and Meisam Shabanian. "Novel thermally stable poly(amide-imide)s containing dibenzalacetone moiety in the main chain: Synthesis and characterization." Macromolecular Research 18, no. 5 (2010): 421–28. http://dx.doi.org/10.1007/s13233-010-0511-3.

Full text
APA, Harvard, Vancouver, ISO, and other styles
23

Aguilera, J. L., G. Sosa, W. F. Reynolds, E. Diaz, and H. Barrios. "Reaction of dibenzalacetone with hydroxylamine hydrochloride under phase-transfer conditions.1H and13C 2D NMR structural elucidation of the products." Magnetic Resonance in Chemistry 27, no. 9 (1989): 823–29. http://dx.doi.org/10.1002/mrc.1260270903.

Full text
APA, Harvard, Vancouver, ISO, and other styles
24

Chauhan, Indira Singh, Simran Marwa, G. Subba Rao, and Neeloo Singh. "Antiparasitic dibenzalacetone inhibits the GTPase activity of Rab6 protein of Leishmania donovani (LdRab6), a potential target for its antileishmanial effect." Parasitology Research 119, no. 9 (2020): 2991–3003. http://dx.doi.org/10.1007/s00436-020-06810-4.

Full text
APA, Harvard, Vancouver, ISO, and other styles
25

Linda Ekawati, Linda Ekawati, Beta Achromi Nurohmah Beta Achromi Nurohmah, Jufrizal Syahri Jufrizal Syahri, and Bambang Purwono Bambang Purwono. "Substituted 3-styryl-2-pyrazoline Derivatives as an Antimalaria: Synthesis, in vitro Assay, Molecular Docking, Druglikeness Analysis and Admet Prediction." Sains Malaysiana 51, no. 10 (2022): 3215–36. http://dx.doi.org/10.17576/jsm-2022-5110-09.

Full text
Abstract:
The synthesis, in vitro antimalarial assay, molecular docking, drug-likeness analysis, and ADMET prediction of substituted 3-styryl-2-pyrazoline derivatives as antimalaria have been conducted. The synthesis of N-phenyl (1a‒3a) and N-acetyl-substituted (1b‒3b) 3-styryl-2-pyrazolines was carried out using dibenzalacetone derivatives and hydrazine hydrate or phenylhydrazine. An in vitro antimalarial assay was conducted against the chloroquine-sensitive Plasmodium falciparum 3D7 strain, while molecular docking was performed toward the crystal protein of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) (PDB ID: 1J3I). Furthermore, the prediction of drug-like properties was determined by assessing Lipinski’s rules, and the pharmacokinetic parameters were also studied in-silico, including absorption, distribution, metabolism, excretion, and toxicity (ADMET). The in vitro assay showed that 3a (IC50 0.101 µM) has excellent antimalarial activity, followed by 2a (0.177 µM), and 1b (0.258 µM). Molecular docking has supported the in vitro assay by showing the lowest CDOCKER energy for 3a (‒56.316 kcal/mol), then 2a (‒51.2603 kcal/mol), and 1b (‒48.8774 kcal/mol). The drug-like properties showed that all of the prepared compounds were acceptable based on Lipinski’s rules and predicted to be potentially orally bioavailable. The ADMET analysis provided information that 3a and 2a could be proposed as the best lead antimalarial drugs with further modification to reduce the lipophilicity and toxicity properties.
APA, Harvard, Vancouver, ISO, and other styles
26

Akatyev, Nikolay, and Albina Samigolla. "Sun protection properties and photostability of aqueous extracts of dandelion (Taraxacum officinale L.)." Prospects in Pharmaceutical Sciences 22, no. 4 (2024): 160–67. https://doi.org/10.56782/pps.285.

Full text
Abstract:
The aim of this study was to determine the sun protection properties and photostability of aqueous extracts of Taraxacum officinale L. growing locally in the West Kazakhstan region. These properties were examined using UV-Vis spectroscopy, and the relevant metrics were calculated using the Mansur equation. Qualitative phytochemical screening revealed the presence of both primary and secondary metabolites in extracts obtained from the whole plant and its parts. The phenolic compounds present in extracts mainly contributed to the absorption of UV rays in the wavelength range of 280–400 nm. Six-week experiments allowed the detection of significant photostability of most of the extracts studied, up to 86.8% for leaf-derived extracts. It was observed that the first few days of exposure caused the greatest loss of sun protection properties of the extracts. It was also confirmed that the concentration of the extracts has a direct influence on the sun protection properties of the aqueous extracts from the roots, leaves, inflorescences, and the whole plant of T. officinale. The study found that the sun protection properties of T. officinale aqueous extracts are comparable to the same properties of dibenzalacetone, a synthetic ingredient commonly found in modern sunscreens. In addition, both the plant parts and the concentration of the extract were found to determine the tested extracts' photostability and sensitivity to direct sunlight.
APA, Harvard, Vancouver, ISO, and other styles
27

Chauhan, Indira Singh, G. Subba Rao, Jai Shankar, Lalit Kumar Singh Chauhan, Govind J. Kapadia, and Neeloo Singh. "Chemoprevention of Leishmaniasis: In - vitro antiparasitic activity of dibenzalacetone, a synthetic curcumin analog leads to apoptotic cell death in Leishmania donovani." Parasitology International 67, no. 5 (2018): 627–36. http://dx.doi.org/10.1016/j.parint.2018.06.004.

Full text
APA, Harvard, Vancouver, ISO, and other styles
28

Hajibeygi, Mohsen, Khalil Faghihi, and Meisam Shabanian. "Preparation and characterization of new photosensitive and optically active poly(amide-imide)s from N-trimellitylimido-L-amino acid and dibenzalacetone moiety in the main chain." Polymer Science Series B 53, no. 9-10 (2011): 518–27. http://dx.doi.org/10.1134/s1560090411090016.

Full text
APA, Harvard, Vancouver, ISO, and other styles
29

Faghihi, Khalil, Akram Feyzi, and Mohsen Hajibeygi. "Synthesis and characterization of new poly(amide-imide)s based on [N,N′-(4,4′-carbonyldiphtaloyl)-bis-L-amino diacid]s and dibenzalacetone moieties in the main chain." Designed Monomers and Polymers 15, no. 5 (2012): 523–32. http://dx.doi.org/10.1080/1385772x.2012.688334.

Full text
APA, Harvard, Vancouver, ISO, and other styles
30

Faghihi, Khalil, Mohsen Hajibeygi, and Meisam Shabanian. "Photosensitive and Optically Active Poly(amide-imide)s Based on N,N- (pyromellitoyl)-bis-L-amino acid and Dibenzalacetone Moiety in the Main Chain: Synthesis and Characterization." Journal of Macromolecular Science, Part A 47, no. 2 (2009): 144–53. http://dx.doi.org/10.1080/10601320903458622.

Full text
APA, Harvard, Vancouver, ISO, and other styles
31

Theresih, Karim, and Cornelia Budimarwanti. "PENGARUH GUGUS p-METOKSI PADA REAKSI KONDENSASI CLAYSEN-SCHMIDT MENGGUNAKAN METODA GRINDING." Jurnal Sains Dasar 5, no. 2 (2016): 124. http://dx.doi.org/10.21831/jsd.v5i2.13719.

Full text
Abstract:
Penelitian ini bertujuan untuk mensintesis senyawa dibenzalaseton, 4-metoksikalkon dan dianizalaseton melalui reaksi kondensasi Claysen Schmidt menggunakan metode grinding dan mengetahui pengaruh gugus p-metoksi pada reaksi tersebut. Sintesis dibenzalaseton menggunakan benzaldehida, aseton, dan NaOH. Senyawa 4-metoksikhalkon disintesis dari campuran 4-metoksibenzaldehida, asetofenon, dan NaOH. Sedangkan sintesis senyawa dianisalseton melalui reaksi Claysen-schmidt antara aseton, anisaldehid, dan katalis basa NaOH dengan perbandingan mol yang digunakan secara berturut-turut 2:1:2. Sintesis dilakukan dengan metode grinding bebas pelarut. Bahan dasar dan katalis digerus secara bersamaan dalam mortir selama 15 menit hingga membentuk pasta yang dikeringkan dan direkristalisasi. Ketiga senyawa hasil yang diperoleh dikarakterisasi menggunakan KLT, FTIR, dan GC-MS. Berdasarkan hasil analisis FTIR dan GC-MS menunjukkan bahwa dibenzalaseton, 4-metoksikhalkon dan dianizalaseton dapat disintesis dan memiliki rendemen berturut-turut 59,93 %, 86,21 % dan 70,39 %. Ada pengaruh gugus p-metoksi pada reaksi kondensasi Claysen-Schmidt pada sintesis senyawa dibenzalaseton, 4-metoksikalkon dan dianizalaseton menggunakan metoda Grinding.Kata kunci : dibenzalaseton, 4-metoksikhalkon , dianizalaseton , metode grinding Abstract This research aims to synthesize the compound dibenzalaceton, 4-methoksikalkon and dianisalaceton through Claysen Schmidt condensation reaction with grinding method and to determine the effect of p-methoxy groups on the reaction. Dibenzalaceton compound was synthesized from benzaldehyde, acetone, and NaOH. Synthesis of compound 4-metoksikhalkon was done using 4-methoxybenzaldehyde, acetophenone, and NaOH. Dianisalceton compound was synthesized through Claysen-schmidt reaction between acetone, anisaldehide, and the catalysts NaOH. This synthesis were performed through solvent-free grinding method. Catalyst base material and simultaneously crushed in mortar for 15 minutes to form a paste. The pasta is dried and recrystallized. The resulted compounds were characterized by TLC, FTIR and GC-MS. Based on the results of the analysis of FTIR and GC-MS showed that dibenzalaceton, 4-methoksikhalkon and dianisalaceton can be synthesized and have succession yield 59.93%, 86.21% and 70.39% . There is the influence of p-methoxy groups in a condensation reaction Claysen-Schmidt on the synthesis of compounds dibenzalaceton, 4-methoksikhalkon and dianizalaceton use grinding method. Keywords: dibenzalaceton, 4-methoksikhalkon, dianizalaceton, grinding method
APA, Harvard, Vancouver, ISO, and other styles
32

Kashyap, Akshay, Treyvon K. Bokosike, Nattamai Bhuvanesh та Mahesh Pattabiraman. "Stereo- and regioselective photocycloaddition of extended alkenes using γ-cyclodextrin". Organic & Biomolecular Chemistry 16, № 38 (2018): 6870–75. http://dx.doi.org/10.1039/c8ob01966e.

Full text
Abstract:
Photoexcitation of dibenzalacetones in homogeneous media and solid state yields a mixture of products with poor conversions. Reactivity of the substrate encapsulated within γ-cyclodextrin results in efficient 2 + 2 photocycloaddition between two reactants on both alkenes groups, yielding a single product with remarkable regio- and stereoselectivity at high conversions.
APA, Harvard, Vancouver, ISO, and other styles
33

Peitzika, Stergiani-Chrysovalanti, Eirini Tsiampakari, and Eleni Pontiki. "Microwave Assisted Synthesis of Antioxidant Dihydro-Pyrazole Hybrids as Possible Lipoxygenase Inhibitors." Molecules 30, no. 10 (2025): 2224. https://doi.org/10.3390/molecules30102224.

Full text
Abstract:
Free radicals and inflammation have pivotal role in various degenerative diseases like cancer, rheumatoid arthritis, diabetes, cardiovascular and neurodegenerative disorders. Pyrazoles possess a wide range of biological activities such as antifungal, antituberculosis, antimicrobial, antiviral, anti-inflammatory, anti-convulsant, anticancer etc. In this present study a series of dibenzalacetones and the corresponding pyrazole hybrids were designed through bioisosterism, synthesized and biologically evaluated to highlight the importance of the extended conjugated system and substitution to the anti-inflammatory and antioxidant activity. The synthesis of dibenzalacetones was achieved via Claisen-Schmidt reaction. The dihydro-pyrazoles were synthesized from the substituted dibenzacetones and phenylhydrazines, hydrazine and semicarbazide under microwave irradiation optimizing reaction conditions. The synthesized compounds were spectroscopically characterized and evaluated for their anti-lipid peroxidation (AAPH) activity, their interaction with the free radical DPPH and the inhibition of soybean LOX. The novel derivatives were studied in terms of their physicochemical properties. Many of the dihydro-pyrazoles showed potent antioxidant properties and significant inhibition of soybean lipoxygenase as a result of their physicochemical features. Compounds 4a and 4b presented the most potent anti-lipid peroxidation abilities (98% and 97%), whereas compounds 2d and 2e have proved to be the most potent lipoxygenase inhibitors with IC50 values 2.5 μM and 0.35 μM. Moreover, docking studies with soybean lipoxygenase highlight the interactions of the novel derivatives with the enzyme.
APA, Harvard, Vancouver, ISO, and other styles
34

Schwarzer, Anke, and Edwin Weber. "Penta- and Decafluorinated Dibenzalacetones: Synthesis, Crystal Structure, and Cocrystallization Experiments." Crystal Growth & Design 14, no. 5 (2014): 2335–42. http://dx.doi.org/10.1021/cg5000342.

Full text
APA, Harvard, Vancouver, ISO, and other styles
35

da Silva, Aline Alves, Pedro Ivo da Silva Maia, Carla Duque Lopes, Sergio de Albuquerque, and Marcelo Siqueira Valle. "Synthesis, characterization and antichagasic evaluation of thiosemicarbazones prepared from chalcones and dibenzalacetones." Journal of Molecular Structure 1232 (May 2021): 130014. http://dx.doi.org/10.1016/j.molstruc.2021.130014.

Full text
APA, Harvard, Vancouver, ISO, and other styles
36

Liu, Ling, Guochun Yang, Yun Geng, Yong Wu, and Zhongmin Su. "Electron transport via phenyl–perfluorophenyl interaction in crystals of fluorine-substituted dibenzalacetones." RSC Adv. 4, no. 91 (2014): 50188–94. http://dx.doi.org/10.1039/c4ra09323b.

Full text
Abstract:
Although substitution with fluorine creates stability in organic electronic materials by altering the molecular crystal packing, the charge transport properties of the materials are significantly affected.
APA, Harvard, Vancouver, ISO, and other styles
37

Al-Majid, Abdullah, Mohammad Islam, Saleh Atef та ін. "Synthesis of Pyridine-Dicarboxamide-Cyclohexanone Derivatives: Anticancer and α-Glucosidase Inhibitory Activities and In Silico Study". Molecules 24, № 7 (2019): 1332. http://dx.doi.org/10.3390/molecules24071332.

Full text
Abstract:
An efficient and practical method for the synthesis of 2,6-diaryl-4-oxo-N,N′-di(pyridin-2-yl)cyclohexane-1,1-dicarboxamide is described in this present study, which occurs through a double Michael addition reaction between diamide and various dibenzalacetones. The reaction was carried out in dichloromethane (DCM) in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). The anticancer activities of the synthesized compounds were evaluated in several cancer cell lines, including MCF-7, MDA-MB-231, SAS, PC-3, HCT-116, HuH-7 and HepG2 cells. From these experiments, we determined that MDA-MB-231 was the most sensitive cancer cell line to the compounds 3c, 3e, 3d, 3j and 3l, which exhibited variable anticancer activities (3l [IC50 = 5 ± 0.25 µM] &gt; 3e [IC50 = 5 ± 0.5 µM] &gt; 3c [IC50 = 7 ± 1.12 µM] &gt; 3d [IC50 = 18 ± 0.87 µM] &gt; 3j [IC50 = 45 ± 3 µM]). Of these, 3l (substituted p-trifluoromethylphenyl and chloropyridine) showed good potency (IC50 = 6 ± 0.78 µM) against HCT-116 colorectal cancer cells and exhibited high toxicity against HuH-7 liver cancer cells (IC50 = 4.5 ± 0.3 µM). These values were three times higher than the values reported for cisplatin (IC50 of 8 ± 0.76 and 14.7 ± 0.5 µM against HCT-116 and HuH-7 cells, respectively). The highest α-glucosidase inhibitory activity was detected for the 3d, 3i and 3j compounds. The details of the binding mode of the active compounds were clarified by molecular docking studies.
APA, Harvard, Vancouver, ISO, and other styles
38

Bargujar, Savita, and Sonia Ratnani. "An Alternative Greener Synthesis of Dibenzalacetone." Organic Preparations and Procedures International, August 12, 2022, 1–3. http://dx.doi.org/10.1080/00304948.2022.2096383.

Full text
APA, Harvard, Vancouver, ISO, and other styles
39

Houshia, Orwa, Abdalla Walwil, Hanan Jumaa, et al. "Assessment of the Ratio of Geometric Isomers of Dibenzalacetone Spectroscopically." Journal of Pharmaceutical Research International, November 12, 2019, 1–9. http://dx.doi.org/10.9734/jpri/2019/v31i430307.

Full text
Abstract:
The aim of this experiment is to estimate the relative ratio of geometric isomers of Dibenzalacetone that was prepared via the crossed-aldol condensation by reacting benzaldehyde with acetone. Dibenzalacetone was synthesized in the lab from benzaldehyde and acetone under basic conditions. The GC-MS was used to relate the molar mass of the product. Thin layer chromatography was used to visualize the relative RF factor for each isomer. Uv-Vis instrument showed three peaks that were assigned to each isomer. And the FT-IR was used for the assignment of the vibrational modes of each isomer. The relative ratio of trans-trans, Cis-trans, and Cis-Cis was 59.87%, 26.53%, and 13.60% respectively with the aid of FT-IR instruments peak assignments were made for the vibrational frequency of the functional groups. For organic laboratory setups and practices, the fragments from the MS spectrum of DBA can be explained based on cleaving or rearrangement in gas phase by mechanisms known as α-cleavage, β-cleavage, and Rearrangement migration.
APA, Harvard, Vancouver, ISO, and other styles
40

de Oliveira, Mauro M., Carlos E. S. Nogueira, Francisco Wagner Q. Almeida-Neto, et al. "Full Spectroscopic Characterization and Cytotoxicity Activity of Synthetic Dibenzalacetone Derivatives." Journal of Molecular Structure, November 2020, 129670. http://dx.doi.org/10.1016/j.molstruc.2020.129670.

Full text
APA, Harvard, Vancouver, ISO, and other styles
41

Dehamchia, Mohamed, Ichrak Bouguessa, Mohamed Aber, Nawal Khier, Samir Bayou, and Zine Régaïnia. "Water-Mediated Synthesis, Antibacterial and Antioxidant Evaluation of New Fused Pyrimido-pyrimidine and Pyrimido-purines Derived From Nucleobases." Current Green Chemistry 10 (July 20, 2023). http://dx.doi.org/10.2174/2213346110666230720152024.

Full text
Abstract:
Introduction: A simple and eco-friendly synthesis of novel substituted pyrimido[1,6-a]pyrimidine, pyrimido[1,2-g]purine, and pyrimido[2,1-e]purine was accomplished by refluxing of nucleobases (cytosine, adenine or guanine) and dibenzalacetone (DBA) in water using NaOH as a catalyst. Method: The molecular structures of the resulting products were characterized by infrared spectroscopy (FT-IR), mass spectrometry, and proton (1H) and carbon (13C) nuclear magnetic resonance (NMR). Result: The antibacterial activity of the newly fused heterocycles was assayed against the Gram-positive bacterium Staphylococcus aureus (ATCC 6538) and Gram-negative Escherichia coli (ATCC 8737) using gentamicin as a standard commercially available antibiotic. Conclusion: In addition, the antioxidant capacity was screened using the 2,2-diphenyl-2-picrylhydrazyl hydrate (DPPH•) and the 2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS+•) radicals scavenging assay.
APA, Harvard, Vancouver, ISO, and other styles
42

Elhaid, M’bark, Elhachmia Ech-chihbi, Ayoub Mouhib, et al. "Design of novel dibenzalacetone-based organic inhibitor responsible for excellent corrosion performance: Electrochemical response and theoretical exploration." Inorganic Chemistry Communications, March 2025, 114236. https://doi.org/10.1016/j.inoche.2025.114236.

Full text
APA, Harvard, Vancouver, ISO, and other styles
43

Abuelella, Khaled E., Saadalla Nady Gaid, Mahmoud Alaaeldin Khattab, Kareem O. Rashwan, and Nermin M. Sheta. "Photoprotective efficacy of dibenzalacetone in sunscreen formulations: Physicochemical properties, synthesis, characterization, potential applications in sunscreen and biological activities." International Journal of Cosmetic Science, July 10, 2025. https://doi.org/10.1111/ics.70002.

Full text
Abstract:
AbstractSunscreens reduce the harmful effects of ultraviolet radiation (UVR) by reflecting, absorbing or scattering photons. UVR comprises ultraviolet‐B (UVB), which plays a major role in sunburn and the development of skin cancers, and ultraviolet‐A (UVA), which contributes to photoaging and skin damage. The application of sunscreen is among the most effective approaches to mitigating UV‐induced damage. As a topical photoprotective agent, it can be classified as either inorganic (physical blockers) or organic (chemical absorbers). Physical sunscreens are particularly beneficial for people who are hypersensitive to UVA and visible light, such as those who have photosensitising diseases. Chemical sunscreens that selectively absorb UVB and/or UVA, include cinnamates, benzophenones, benzimidazoles and dibenzalacetone (DBA). DBA is a synthetic compound with potent UV‐absorbing properties, making it an important component in sunscreen formulations for effective skin protection. This review provides a comprehensive analysis of DBA, focusing on its physicochemical properties, conventional synthesis methods and structural characterization using UV–Visible absorption spectroscopy, Fourier Transform Infrared (FTIR) spectroscopy, Gas Chromatography–Mass Spectrometry (GC–MS) and Nuclear Magnetic Resonance (NMR) spectroscopy. Furthermore, its potential applications in sunscreen formulations and other biological activities are critically investigated.
APA, Harvard, Vancouver, ISO, and other styles
44

Abyyu, Aulia, Rijal Baihaki Kusuma, Anindya Khairunnisa, et al. "Green Synthesis, Bio-evaluation, and In Silico Study of Dibenzalacetone: A Curcumin Analog for The Medicinal Treatment of Inflammatory Diseases." Biocatalysis and Agricultural Biotechnology, March 2025, 103561. https://doi.org/10.1016/j.bcab.2025.103561.

Full text
APA, Harvard, Vancouver, ISO, and other styles
45

Faghihi, Khalil, Mohsen Hajibeygi, and Meisam Shabanian. "Synthesis and properties of new photosensitive and chiral poly(amide-imide)s based on bicyclo[2,2,2]oct-7-ene-2,3,5,6-tetracarboxylic diimide and dibenzalacetone moieties in the main chain." Polymer International, 2009, n/a. http://dx.doi.org/10.1002/pi.2711.

Full text
APA, Harvard, Vancouver, ISO, and other styles
46

ORLOV, V. D., KH KIROGA, A. MARRUGO, N. N. KOLOS, and S. V. IKSANOVA. "ChemInform Abstract: Reactions of 4,5-Diamino-3-methyl-1-phenylpyrazole with Dibenzalacetones." ChemInform 19, no. 23 (1988). http://dx.doi.org/10.1002/chin.198823257.

Full text
APA, Harvard, Vancouver, ISO, and other styles
47

Moghaddam, Firouz Matloubi, Vahid Saberi, and Ashkan Karimi. "Highly diastereoselective cascade [5 + 1] double Michael reaction, a route for the synthesis of spiro(thio)oxindoles." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-021-01766-6.

Full text
Abstract:
AbstractThe first diastereoselective synthesis of spirothiooxindoles is reported via the Michael reaction between thiooxindoles and dibenzalacetones. The reaction was conducted without any catalyst or additive under green conditions, i.e., ethanol as the solvent and at room temperature. In addition, the described robust method benefits from scalability, simple work-up, and column chromatography-free purification. This work demonstrates the art of governing regio- and stereoselectivity, which has been discussed in the light of Density Functional Theory calculations. Our method represents the first synthesis of spiro[cyclohexanone-thiooxindoles] with the relative configuration of the aryl moieties at the cyclohexanone ring as cis. The obtained cis-spirothiooxindoles, can be used to afford cis-spirooxindoles, which their synthesis had not been explored before. According to our molecular docking studies, cis-spirooxindoles demonstrate higher binding affinities than corresponding trans-spirooxindoles for the OPRT domain of the Leishmania donovani uridine 5′-monophosphate synthase (LdUMPS). Thus, the reported method may eventually be utilized to develop new hit compounds for leishmaniasis treatment.
APA, Harvard, Vancouver, ISO, and other styles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography