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Journal articles on the topic 'Diclofenac'

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1

Shumyantseva, V. V., E. V. Shich, A. A. Machova, T. V. Bulko, V. G. Kukes, O. S. Sizova, G. V. Ramenskaya, S. A. Usanov, and A. I. Archakov. "The influence of vitamin B group on monooxygenase activity of cytochrome P450 3A4: pharmacokinetics and electro analysis of catalytic properties." Biomeditsinskaya Khimiya 57, no. 3 (2011): 343–54. http://dx.doi.org/10.18097/pbmc20115703343.

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It was shown that vitamin B group permit to shorten the longitude of diclofenak therapy and to reduce the daytime dose of this drug. All three schemes of diclofenac treatment - only diclofenac, diclofenac plus 2 tablets of Gitagamp (mixture of vitamin B group), and diclofenac plus 4 tablets of Gitagamp - gave maximum value of diclofenal in blood through 1 hour after treatment. In the case of diclofenak treatment without vitamins Cmax corresponds to 1137.2±82.4 ng/ml, with 2 tablets of Gitagamp - Cmax 1326.7±122.5 ng/ml, and with 4 tablets - Cmax 2200.4±111.3 ng/ml. Positive influence of vitamin B group on the decrease of pain syndrome was shown. Pharmacodynamics and pharmacokinetics data were confirmed in electrochemical experiments with cytochrome P450 3A4. For enzyme immobilization screen printed graphite electrodes modified with gold nanoparticles and synthetic membrane-like compound didodecyldimethylammonium bromide (DDAB/Au) were used. Electrochemical analysis reviled the influence of vitamin B group on metabolism of non steroid anti inflammation drug diclofenac catalyzed by cytochrome P450 3A4. Riboflavin was the most effective inhibitor of diclofenac hydroxylation by cytochrome P450 3A4 as was compared at 300 M concentration of vitamin B group (B1, B2, B6). These data confirmed the opportunity of pharmacokinetic parameters regulation and the level of pharmacodynamic effects by the influence of vitamin B group on the catalytic activity of cytochrome P450 3A4.
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2

Frah Razzaq Kbyeh and Ahmed N. Abedsalih. "Study the Antibacterial Mechanism of Diclofenac and its Activity Alone or Combined with Ciprofloxacin in Treating Urinary Tract Infection." Wasit Journal for Pure sciences 2, no. 3 (September 30, 2023): 292–310. http://dx.doi.org/10.31185/wjps.191.

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This study aimed to compare the effects of diclofenac, ciprofloxacin and their combination groups on urine tract infection (U.T.I.s) caused by resistance E coli 0157 H7 in vitro and in vivo. Two hundred urine samples were collected from adult women patients suffering from U.T.I.s from February 2022 to July 2022. The urine specimen was cultured on the blood agar and then incubated at 37°C for (1-2) days; MacConkey agar is the media used for determining the biochemistry results, and identification by Rapidchek test which was performed on typical colonies from the selective plate. The M.I.C effect of Diclofenac began at (25600µg/ml) against resistance E coli 0157H7 while M.I.C of ciprofloxacin it was at (0.96mg/ml), but M.I.C of a combination between (diclofenacn+ciprofloxacin) it was at (400+0.48) mg/ml. Resistance induction assay,with the ciprofloxacin has increased four times, while with the diclofenac has doubled, whilst the combination between (diclofenacn+ciprofloxacin) has no changed after 21 days, according to M.I.C.in the time-kill assay, it was proved that the ciprofloxacin and the combination between (diclofenacn+ciprofloxacin) works after 6 hours, compared to the diclofenac, which started to reduce bacterial counting after 40. After that, the examination was carried out by scanning electronic microscope (S.E.M.) to exam the mechanics of diclofenac,work which was found that it was works as anti-biofilm In this study, forty-eighth (48) rabbits were used and divided into six groups as follow positive control (P.C.), negative control (N.C.), diclofenac (D.C.) in 1mg/kg group, ciprofloxacin (C.I.P.)in7mg/kg group, combination (ciprofloxacin 3.5 mg/kg+diclofenac1mg/kg)COM1 group and combination (ciprofloxacin 1.75 mg/kg+diclofenac1mg/kg) com2 All animals (injected with 0.1 ml in CFU E coli 0157 H7 by urinary catheterization route excepting negative control all group excepting negative control resulted in a significant increase in pus cell, epithelium cell concentration in the urine after three days E coli 0157 H7 infection comparison with negative control while in all experimental period after (14 days) showed no significant (P < 0.05) between positive control (P.C.) and diclofenac treated groups but combination COM1 group and com2 decrease significantly (P< 0.05) after (seven and fourteen) days comparison with positive control. diclofenac can be combined with antibiotics as an anti-virulence agent, enhancing the immune system's ability to eradicate infection
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Gowtham, Dr S. E. "A Comparative Study of Diclofenac with Paracetamol versus Diclofenac with Serratiopeptidase in Pain Associated with Soft Tissue Injury." International Journal for Research in Applied Science and Engineering Technology 9, no. 8 (August 31, 2021): 2740–44. http://dx.doi.org/10.22214/ijraset.2021.37848.

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Abstract: The point of the executives is to ease the pain rapidly and improve practical capacity. NSAIDs are the primary line treatment. Serratiopeptidase is the proteolytic enzyme. The challenge lies in deciding whether only NSAIDs or NSAIDs with proteolytic enzyme will give more prominent indicative help, while additionally being savvy. the primary goal is to think about the adequacy of diclofenac with paracetamol and diclofenac with serratiopeptidase in the administration of delicate tisssue injury. This prospective, open label, observational study was conducted at a tertiary care hospital. Patients over 18 years of age and presenting with soft tissue injury pain (elbow pain, knee pain, general pain, back pain ) of less than 6 weeks duration were enrolled in the study. Forty patients with soft tissue injury pain were randomized into two groups: Group A got diclofenac with paracetamol (50mg/325mg) double a day and Group B got diclofenac with serratiopeptidase (50mg/10mg) double a day for 1 week. The Numerical Rating Scale (NRS) determined the clinically significant results. The decrease in pain intensity in Group B was (MEAN= 3.76), while in Group A it was (MEAN= 3.93). The average cost-effectiveness ratio indicated that diclofenac wit paracetamol was the dominant treatment over diclofenac with serratiopeptidase. Therefore, diclofenacc with paracetamol was found to be the cost-effective option for soft tissue injury pain relief in for 1 week. Both diclofenac wit paracetamol and diclofenac with serratiopeptidase. were clinically effective in reducing the pain intensity and in improving functional ability. H owever, diclofenac wit paracetamol was found to be the cost-effective intervention. Keywords: Paracetamol, diclofenac, Serratiopeptidase, soft tissue injury, pain.
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Guzmán, Miriam Franco, Luis Humberto Mendoza Huizar, Carlos Andrés Galán Vidal, Gabriela Roa Morales, and Giaan A. Álvarez Romero. "A Box-Behnken Optimized Methodology for the Quantification of Diclofenac using a Carbon Paste-Multiwalled Carbon Nanotubes Electrode." Current Analytical Chemistry 15, no. 3 (May 7, 2019): 294–304. http://dx.doi.org/10.2174/1573411014666180423151749.

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Background: Diclofenac is a widely used nonsteroidal anti-inflammatory drug. Recent studies have shown that frequent consumption of this drug in high concentrations can cause heart diseases, so strict control of diclofenac’s quantity in commercial drugs is necessary. This paper presents the development of an optimized voltammetric methodology for the quantification of diclofenac, which offers some advantages over other electrochemical and accepted methods. Objective: Optimize with a Box-Behnken design the differential pulse voltammetry parameters towards the quantification of diclofenac in pharmaceutical samples. Methods: Diclofenac behavior in the working electrode was evaluated by cyclic voltammetry, in order to stablish the best conditions for diclofenac’s quantification. A Box-Behnken design was then used to optimize the differential pulse voltammetry parameters and stablish the analytical behavior of the proposed methodology. Commercial tablets were prepared for analysis according to the Pharmacopeia, the DPV optimized methodology was used to quantify diclofenac in the samples, and the results were statistically compared with those obtained with the official methodology. Results: After optimization, the analytical parameters found were: correlation coefficient of 0.998, detection limit of 0.001 µM, quantification limit of 0.0033 µM and sensitivity of 0.299 µA.µM-1. The statistical analysis showed there were no significant differences between the results obtained with the proposed methodology and those obtained with the official methodology. Conclusion: The statistical analysis showed that the proposed methodology is as reliable as the official spectrophotometric one for the quantification of diclofenac in commercial drugs, with very competitive analytical parameters, and even better to others found with more complex electrodes.
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Rao, Varsha, Vidya Patil, Anusha Suntan, and Shivanand LK. "The Efficacy of Transdermal Diclofenac Patch for Postoperative Analgesia in Comparison with Intramuscular Diclofenac in Patients Undergoing Lower Abdominal and Perineal Surgeries Under Sub-Arachnoid Block A Randomised Comparative." Indian Journal of Anesthesia and Analgesia 8, no. 5 (October 15, 2021): 531–35. http://dx.doi.org/10.21088/ijaa.2349.8471.8521.78.

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Background: Although, postoperative pain is a distinctive and most common form of pain, it remains poorly treated. Aim: To evaluate the efficacy of Transdermal diclofenac patch versus IM diclofen patients undergoing lower abdominal and perineal surgeries under Subarachnoid during postoperative period. Methodology: This randomised comparative study included 90 ASA I and II patien either sex aged 18 – 60 years. Patients were randomly divided by computer generated into two groups of 45 patients each. Group A was applied with a Transdermal Diclofenac (100mg) at the beginning of surgery after subarachnoid block. In groupB 75mg of Diclofenac sodium was given intramuscularly half an hour befo end of surgery. Data was analysed using Chi-square test and Mann Whitney U test Results: The mean difference in the time of administration of rescue analgesia in grou 8hr 37 mins ± 1 hr 4.2 mins and group B is 6hrs 19 mins ±58.6 mins ( P value is < 0.0001 ) effects in group A were very minimal. Conclusion: Thus transdermal diclofenac patch is effective, non- invasive and safer w treating postoperative pain. Keywords: Transdermal Diclofenac Patch, Im Diclofenac, Postoperative Analgesia.
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6

Zapata-Morales, Ana Laura, Sarai Vega-Rodriguez, Ma Catalina Alfaro de la Torre, Alejandro Hernández-Morales, Socorro Leyva-Ramos, and Ruth Elena Soria-Guerra. "Efficiency of Cattail to Remove a Mixture of Pharmaceuticals in a Constructed Wetland." Journal of the Mexican Chemical Society 67, no. 1 (January 1, 2023): 1–11. http://dx.doi.org/10.29356/jmcs.v67i1.1848.

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Reducing the risk of the aquatic ecosystem’s contamination with organic substances such as pharmaceuticals is of great importance due to the toxicological effect of these substances on aquatic organisms. Therefore, the removal of pharmaceuticals and/or their metabolites frequently reported in industrial or municipal wastewaters require efficient processes that complement the conventional treatment systems; the constructed wetlands are an option. In this work, the removal efficiency of mixed diclofenac and naproxen was evaluated using a subsurface flow constructed wetland planted with cattail (Typha latifolia), operated during 100 days at a hydraulic residence time (HRT) of 3 days. Under these conditions, the diclofenac and naproxen removal efficiencies were 82.0% and 74.5%, respectively. The interaction between diclofenac and naproxen with cellulose, which is the major cell wall compound of higher plants, was computationally modeled at the PM6 semi-empirical level of theory and it was found that diclofenac and naproxen interact with cellulose via hydrogen bonds. Resumen. Reducir el riesgo de contaminación de los ecosistemas acuáticos con sustancias orgánicas como los fármacos es de gran importancia debido al efecto toxicológico de estas sustancias para los organismos acuáticos. Por ello, la remoción de los fármacos y/o sus metabolitos frecuentemente reportados en aguas residuales industriales o municipales requiere de procesos eficientes que complementen los sistemas convencionales de tratamiento; los humedales construidos son una opción. En este trabajo, se evaluó la eficiencia de remoción de diclofenaco y de naproxeno en mezcla utilizando un humedal construido de flujo subsuperficial con plantas de tule (Typha latifolia), operado durante 100 días con un tiempo de residencia hidráulica (TRH) de 3 días. En estas condiciones, las eficiencias de remoción de diclofenaco y de naproxeno fueron de 82.0 % y 74.5 % respectivamente. La interacción entre diclofenaco y naproxeno con celulosa, que es el componente mayoritario de la pared celular de las plantas superiores, se modeló computacionalmente al nivel de teoría semiempírico con el método PM6, y se encontró que diclofenaco y naproxeno interactúan con celulosa mediante puentes de hidrógeno.
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7

Barrros Gomes, Paulo Roberto, Victor Elias Mouchrek Filho, Rayone Wesly Santos de Oliveira, Adriana Pereira Everton, Jonas Batista Reis, Hilton Costa Louzeiro, Wellington Da Silva Lyra, Maria Alves Fontenele, and Danila Teresa Valeriano Alves. "Utilização dos métodos automáticos em fluxos com detecção espectrofotométrica na determinação de diclofenaco de sódio em formulações farmacêuticas e fluidos corporais." Revista Colombiana de Ciencias Químico-Farmacéuticas 48, no. 1 (January 1, 2019): 29–43. http://dx.doi.org/10.15446/rcciquifa.v48n1.80063.

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Este trabalho descreveu e comparou quatro estudos entre si que utilizaram métodos automáticos em fluxo com detecção espectrofotométrica e a reação de oxidação do diclofenaco para determinar diclofenaco em formulações farmacêuticas e fluidos corporais. Para isso, utilizamos os seguintes artigos: Versatility of a multicommuted flow system in the spectrometric determination of three analytes, Sequential injection spectrophotometric method for the assay of anti-inflammatory diclofenac sodium in pharmaceutical preparations, Screening of conditions controlling spectrophotometric sequential injection analysis e Sequential injection spectrophotometric determination of diclofenac in urine and pharmaceutical formulations e detalhamos as metodologias empregadas, os resultados, conclusões obtidas e comparamos entre eles os limites de detecção, desvio padrão relativo e a frequência analítica. Os resultados mostraram diferenças significativas entre métodos empregados e a utilização do Sistema automático do tipo Análise por Injeção Sequencial, apesar deste possuir menor frequência analítica.
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&NA;. "Diclofenac see Aspirin/diclofenac." Reactions Weekly &NA;, no. 355 (June 1991): 6. http://dx.doi.org/10.2165/00128415-199103550-00026.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 1379 (November 2011): 14–15. http://dx.doi.org/10.2165/00128415-201113790-00048.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 1388 (February 2012): 13. http://dx.doi.org/10.2165/00128415-201213880-00048.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 691 (March 1998): 7. http://dx.doi.org/10.2165/00128415-199806910-00024.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 693 (March 1998): 10. http://dx.doi.org/10.2165/00128415-199806930-00031.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 705 (June 1998): 6–7. http://dx.doi.org/10.2165/00128415-199807050-00017.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 714 (August 1998): 8. http://dx.doi.org/10.2165/00128415-199807140-00026.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 729 (November 1998): 8. http://dx.doi.org/10.2165/00128415-199807290-00028.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 740 (February 1999): 7. http://dx.doi.org/10.2165/00128415-199907400-00014.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 742 (March 1999): 7. http://dx.doi.org/10.2165/00128415-199907420-00020.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 764 (August 1999): 7. http://dx.doi.org/10.2165/00128415-199907640-00020.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 1179 (November 2007): 14. http://dx.doi.org/10.2165/00128415-200711790-00041.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 1188 (February 2008): 10. http://dx.doi.org/10.2165/00128415-200811880-00031.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 1194-1195 (March 2008): 16. http://dx.doi.org/10.2165/00128415-200811940-00053.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 1196 (April 2008): 15. http://dx.doi.org/10.2165/00128415-200811960-00045.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 1127 (November 2006): 10. http://dx.doi.org/10.2165/00128415-200611270-00031.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 1134 (January 2007): 12. http://dx.doi.org/10.2165/00128415-200711340-00043.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 1135 (January 2007): 15. http://dx.doi.org/10.2165/00128415-200711350-00056.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 1141 (March 2007): 11–12. http://dx.doi.org/10.2165/00128415-200711410-00042.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 1355 (June 2011): 16. http://dx.doi.org/10.2165/00128415-201113550-00050.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 1360 (July 2011): 16. http://dx.doi.org/10.2165/00128415-201113600-00047.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 1366 (August 2011): 13. http://dx.doi.org/10.2165/00128415-201113660-00045.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 1367 (September 2011): 16–17. http://dx.doi.org/10.2165/00128415-201113670-00051.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 537 (February 1995): 6. http://dx.doi.org/10.2165/00128415-199505370-00021.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 541 (March 1995): 5. http://dx.doi.org/10.2165/00128415-199505410-00019.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 544 (April 1995): 6. http://dx.doi.org/10.2165/00128415-199505440-00019.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 547 (April 1995): 6. http://dx.doi.org/10.2165/00128415-199505470-00015.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 568 (September 1995): 7. http://dx.doi.org/10.2165/00128415-199505680-00019.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 577 (November 1995): 5. http://dx.doi.org/10.2165/00128415-199505770-00020.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 580 (December 1995): 5. http://dx.doi.org/10.2165/00128415-199505800-00010.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 581 (December 1995): 6. http://dx.doi.org/10.2165/00128415-199505810-00018.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 585 (January 1996): 6. http://dx.doi.org/10.2165/00128415-199605850-00022.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 589 (February 1996): 6. http://dx.doi.org/10.2165/00128415-199605890-00015.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 426 (November 1992): 8. http://dx.doi.org/10.2165/00128415-199204260-00034.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 432 (December 1992): 9. http://dx.doi.org/10.2165/00128415-199204320-00048.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 433 (January 1993): 8. http://dx.doi.org/10.2165/00128415-199304330-00033.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 436 (January 1993): 6. http://dx.doi.org/10.2165/00128415-199304360-00020.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 437 (February 1993): 7. http://dx.doi.org/10.2165/00128415-199304370-00027.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 440 (February 1993): 7. http://dx.doi.org/10.2165/00128415-199304400-00018.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 455 (June 1993): 7. http://dx.doi.org/10.2165/00128415-199304550-00024.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 456 (June 1993): 7. http://dx.doi.org/10.2165/00128415-199304560-00032.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 459 (July 1993): 6. http://dx.doi.org/10.2165/00128415-199304590-00029.

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&NA;. "Diclofenac." Reactions Weekly &NA;, no. 468 (September 1993): 6. http://dx.doi.org/10.2165/00128415-199304680-00028.

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