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Journal articles on the topic 'Diethylcarbamazine'

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Published: 4 June 2021
Last updated: 1 February 2022

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1

&NA;. "Diethylcarbamazine." Reactions Weekly &NA;, no. 507 (June 1994): 8. http://dx.doi.org/10.2165/00128415-199405070-00034.

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2

&NA;. "Diethylcarbamazine." Reactions Weekly &NA;, no. 368 (September 1991): 6. http://dx.doi.org/10.2165/00128415-199103680-00020.

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3

Kitchen, L. W. "Diethylcarbamazine-Related Immunity." Journal of Infectious Diseases 172, no. 6 (December 1, 1995): 1639. http://dx.doi.org/10.1093/infdis/172.6.1639.

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4

Lee, Sukhyang. "Analysis of diethylcarbamazine and diethylcarbamazine-N-oxide by gas chromatography." Archives of Pharmacal Research 19, no. 6 (December 1996): 475–79. http://dx.doi.org/10.1007/bf02986014.

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5

Bhavani, Podili, Seelam Mohan, and Kammela Prasada Rao. "STABILITY INDICATING RP-HPLC METHOD FOR THE ESTIMATION OF DIETHYLCARBAMAZINE CITRATE, GUAIPHENESIN AND CHLORPHENIRAMINE MALEATE." International Journal of Applied Pharmaceutics 10, no. 1 (January 6, 2018): 124. http://dx.doi.org/10.22159/ijap.2018v10i1.22180.

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Objective: The present work describes the development and subsequent validation of a simple, precise and stability–indicating reversed-phase high-performance liquid chromatography (RP-HPLC) method for the simultaneous estimation of diethylcarbamazine citrate, guaiphenesin and chlorpheniramine maleate in tablet dosage forms.Methods: A simple, accurate, precise and robust RP-HPLC method was developed and validated for the estimation of diethylcarbamazine citrate, guaiphenesin and chlorpheniramine maleate. The chromatographic separation of all the three active components was achieved by using luna phenyl-hexyl column (250 mmx4.6 mm, dp=5 µm) with a mobile phase consisting of isocratic method with 0.1% triethylamine as buffer along with orthophosphoric acid adjusted to PH 2.5: acetonitrile (50:50v/v) at a flow rate 1.0 ml/min and ultraviolet detection at 210 nm.Results: The retention time of chlorpheniramine maleate, guaiphenesin and diethylcarbamazine citrate were 2.86, 4.89 and 7.76 min respectively. Validation of the proposed method was carried out according to an international conference on harmonization (ICH) guidelines. The established method was linear in the range of 1-15, 0.6-9, 0.02-0.3 µg/ml and correlation coefficient was 0.999, 0.9991, and 0.993 for diethylcarbamazine citrate, guaiphenesin and chlorpheniramine maleate respectively.Conclusion: The proposed method can be used for the quantitative analysis of diethylcarbamazine citrate, guaiphenesin and chlorpheniramine maleate.
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6

Sklaver, Lilliam, and Craig Murray. "Availability of diethylcarbamazine citrate." American Journal of Health-System Pharmacy 43, no. 12 (December 1, 1986): 2987. http://dx.doi.org/10.1093/ajhp/43.12.2987.

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7

Rogers, F. B., R. Dunn, and A. Barrett. "Diethylcarbamazine: A Leukotriene Inhibitor." International Journal of Microcirculation 14, no. 1-2 (1994): 22–26. http://dx.doi.org/10.1159/000178202.

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8

&NA;. "Doxycycline ?? diethylcarbamazine, albendazole in filariasis." Inpharma Weekly &NA;, no. 1635 (April 2008): 16. http://dx.doi.org/10.2165/00128413-200816350-00032.

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9

Aires, S. T., D. S. S. Paiva, L. V. Santos, D. N. Paiva, P. R. M. Rocco, and W. A. Zin. "Respiratory mechanics after chronic diethylcarbamazine." Respiration Physiology 108, no. 1 (April 1997): 73–77. http://dx.doi.org/10.1016/s0034-5687(97)02528-0.

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10

&NA;. "Single-dose diethylcarbamazine reduces microfilaraemia." Inpharma Weekly &NA;, no. 737 (May 1990): 10–11. http://dx.doi.org/10.2165/00128413-199007370-00026.

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11

Nutman, Thomas B., Kirk D. Miller, Maurita Mulligan, G. Nicholas Reinhardt, Bart J. Currie, Cathy Steel, and Eric A. Ottesen. "Diethylcarbamazine Prophylaxis for Human Loiasis." New England Journal of Medicine 319, no. 12 (September 22, 1988): 752–56. http://dx.doi.org/10.1056/nejm198809223191204.

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12

Duke, B. O. L. "Effect of diethylcarbamazine on adultLoain monkeys." Annals of Tropical Medicine & Parasitology 84, no. 4 (January 1990): 387–92. http://dx.doi.org/10.1080/00034983.1990.11812484.

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13

Sivashankar, M., and A. C. N. Nandasena. "A Patient with Milky Urine: Nonparasitic Chyluria and Silver Nitrate Sclerotherapy." Case Reports in Urology 2020 (July 23, 2020): 1–3. http://dx.doi.org/10.1155/2020/8853473.

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Chyluria has become a rare clinical presentation in Sri Lanka, which may have a direct correlation with the low prevalence of lymphatic filariasis following the use of diethylcarbamazine and albendazole mass drug administration (MDA) for five rounds between 2002 and 2006. Here we report a 50-year-old male who presented with milky urine and progressive weight loss, diagnosed as having nonparasitic chyluria. The patient was initially managed with a trail of diethylcarbamazine (DEC) 6 mg/kg/day for 21 days and a low-fat diet with an unsatisfactory response. Subsequent management with endoscopic instillation of 0.5% silver nitrate brought in him a quick response, which was maintained for a year. Endoscopic sclerotherapy is considered a safer, effective and a minimally invasive treatment option for symptomatic patients.
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14

Nasution, Windya Sari, Muhammad Ali, Ayodhia Pitaloka Pasaribu, Syahril Pasaribu, and Chairuddin P. Lubis. "Albendazole alone vs. albendazole and diethylcarbamazine combination therapy for trichuriasis." Paediatrica Indonesiana 54, no. 2 (April 30, 2014): 109. http://dx.doi.org/10.14238/pi54.2.2014.109-13.

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Background Trichuris trichiura is one of the most commonsoil-transmitted helminths, estimated to infect l billion peopleworldwide. Several studies have compared the efficacies ofalbendazole and diethylcarbamazine, but the efficacy of acombination of these two drugs has been inconclusive.Objective To assess the effectiveness of a single dose ofalbendazole compared to a combination of albendazole anddiethylcarbamazine for trichuriasis treatment.Methods A randomized, clinical open trial was conducted fromJune to September 2009 on elementary school children withtrichuriasis from two villages in the North Sumatera Province.Stool specimens were collected at baseline and at days 7, 14,21, and 28 after treatment, and examined by the Kato Katzmethod. Subjects were randomized into two groups. Group Ireceived a single dose of albendazole (400 mg) and group IIreceived albendazole (400 mg) plus diethylcarbamazine (6 mg!kg). Statistical analyses used were Chi square test for cure ratesand Wilcoxon rank test for egg reduction rates.Results One hundred eight children were enrolled andrandomized into group l (53 children) and group II (55children). The prevalence of T. trichiura infection was 54.7%.There were no significant differences (P=0.52) in the curerate between groups I and II (66% and 60%, respectively) or inegg reduction rates at day 28 (54.5% and 60.07%, respectively,P= 0.10).Conclusion Albendazole alone and abendazole combinedwith diethylcarbamazine have similar efficacies for trichuriasistreatment, in terms of cure rates and egg reduction rates.
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15

Kitler, Mary Ellen, and Nevio Zagaria. "Ensuring Supplies of Quality Diethylcarbamazine Citrate (DEC)." Journal of Clinical Pharmacology 43, no. 5 (May 2003): 477–90. http://dx.doi.org/10.1177/0091270003251856.

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16

&NA;. "Ivermectin compares well with diethylcarbamazine for filariasis." Inpharma Weekly &NA;, no. 735 (May 1990): 8–9. http://dx.doi.org/10.2165/00128413-199007350-00017.

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17

Parasurama Jawaharlal, Jeya Prita, Prince Rajaiah Prabhu, Anugraha Gandhirajan, Nithya Krishnan, and Kaliraj Perumal. "Immunoadjuvant effect of diethylcarbamazine in experimental filariasis." International Immunopharmacology 24, no. 2 (February 2015): 458–62. http://dx.doi.org/10.1016/j.intimp.2014.12.034.

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18

Roy, B., and R. K. Das. "Genotoxic potential of diethylcarbamazine, an antifilarial drug." Toxicology Letters 44, no. 1-2 (November 1988): 7–12. http://dx.doi.org/10.1016/0378-4274(88)90123-3.

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19

Peixoto, Christina Alves, and Bruna Santos Silva. "Anti-inflammatory effects of diethylcarbamazine: A review." European Journal of Pharmacology 734 (July 2014): 35–41. http://dx.doi.org/10.1016/j.ejphar.2014.03.046.

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20

Mak, J. W., P. L. W. Lam, M. F. Choong, and K. Suresh. "Antifilarial activity of intravenous suramin and oral diethylcarbamazine citrate on subperiodic Brugia malayi in the leaf-monkey, Presbytis cristata." Journal of Helminthology 64, no. 2 (June 1990): 96–99. http://dx.doi.org/10.1017/s0022149x00011986.

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ABSTRACTThe known filaricides, suramin and diethylcarbamazine citrate, were tested against subperiodic Brugia malayi infection in the leaf-monkey, Presbytis cristata. As expected, intravenous suramin at 10 mg/kg daily × 5 days or 17 mg/kg weekly × 5 weeks, did not show any microfilaricidal activity, but substantially reduced the recovery of live adult worms to 50·6% and 13·6% of controls respectively. Oral diethylcarbamazine citrate at 6 mg/kg daily × 6 or 10 days reduced final microfilarial counts to 30% of initial counts four weeks post-treatment and adult worm recovery was reduced to 4·5% and 0% of controls respectively. Although the antifilarial activity of these drugs against the infection in this non-human primate model appears to be similar to that seen in man, these results have to be confirmed using larger groups of animals.
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21

BOCKARIE, MOSES J., DANIEL J. TISCH, LIVINGSTONE TAVUL, IRVIN IBAM, JAMES W. KAZURA, FRED HAZLETT, MICHAEL P. ALPERS, and WILL KASTENS. "EFFICACY OF SINGLE-DOSE DIETHYLCARBAMAZINE COMPARED WITH DIETHYLCARBAMAZINE COMBINED WITH ALBENDAZOLE AGAINST WUCHERERIA BANCROFTI INFECTION IN PAPUA NEW GUINEA." American Journal of Tropical Medicine and Hygiene 76, no. 1 (January 1, 2007): 62–66. http://dx.doi.org/10.4269/ajtmh.2007.76.62.

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22

Gessler Stähelin and Nüesch. "Patientin aus Kamerun mit rezidivierenden, transienten, juckenden Schwellungen an Armen und Beinen." Praxis 95, no. 37 (September 1, 2006): 1423–25. http://dx.doi.org/10.1024/1661-8157.95.37.1423.

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Wir berichten über eine 36-jährige, aus Kamerun stammende Patientin mit rezidivierenden, transienten Schwellungen an den Extremitäten verbunden mit starkem Juckreiz. Zudem Augensymtome mit zeitweiligem Gefühl, «als ob ein Wurm ihr Auge durchquere». Die weitere Diagnostik ergab ein Eosinophilie und die Filarienserologie war positiv, sodass die Verdachtsdiagnose einer Loiasis mit rezidivierenden Kalabarschwellungen bestätigt werden konnte. Der Mikrofilariennachweis im Blut und Urin gelang nicht, was wir auf die geringe Mikrofilariendichte zurückführten. Unter einer Einmaldosis Ivermectin (43 × 3 mg) war die Patientin in der Folge beschwerdefrei. Die Loiasis kommt vorwiegend im tropischen Regenwald Zentral- und Westafrikas vor und gehört zu den Filariosen. Die Übertragung erfolgt durch die tagaktive Chrysopsfliege. Die Krankheit verursacht meist keine erntshaften Schäden, führt jedoch in endemischen Gebieten zu chronischen Beschwerden. Eine medikamentöse Therapie ist mit Diethylcarbamazine, Ivermectin oder auch Albendazol möglich. Prävention erfolgt durch schützende helle Kleidung, Anwendung von Insektensprays und allenfalls präventive Therapie mit Diethylcarbamazine oder Ivermectin.
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23

Gelband, Hellen. "Diethylcarbamazine Salt in the Control of Lymphatic Filariasis." American Journal of Tropical Medicine and Hygiene 50, no. 6 (June 1, 1994): 655–62. http://dx.doi.org/10.4269/ajtmh.1994.50.655.

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24

Ribeiro, Edlene Lima, Ingrid Tavares Fragoso, Fabiana Oliveira dos Santos Gomes, Amanda Costa Oliveira, Amanda Karoline Soares e. Silva, Patrícia Martins e. Silva, Bianca Torres Ciambarella, Isalira Peroba Rezende Ramos, and Christina Alves Peixoto. "Diethylcarbamazine: A potential treatment drug for pulmonary hypertension?" Toxicology and Applied Pharmacology 333 (October 2017): 92–99. http://dx.doi.org/10.1016/j.taap.2017.08.015.

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25

Junnila, Amy, D. Scott Bohle, Roger Prichard, Inna Perepichka, and Carla Spina. "Fluorescent Diethylcarbamazine Analogues: Sites of Accumulation inBrugia malayi." Bioconjugate Chemistry 18, no. 6 (November 2007): 1818–23. http://dx.doi.org/10.1021/bc0701040.

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26

Vijayan, V. K., K. V. Kuppu Rao, K. Sankaran, P. Venkatesan, and R. Prabhakar. "Tropical eosinophilia: clinical and physiological response to diethylcarbamazine." Respiratory Medicine 85, no. 1 (January 1991): 17–20. http://dx.doi.org/10.1016/s0954-6111(06)80205-2.

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27

Cesbron, Jean-Yves, André Capron, Boris B. Vargaftig, Michel Lagarde, Joël Pincemail, Pierre Braquet, Henri Taelman, and Michel Joseph. "Platelets mediate the action of diethylcarbamazine on microfilariae." Nature 325, no. 6104 (February 1987): 533–36. http://dx.doi.org/10.1038/325533a0.

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28

Eberhard, M. L., P. J. Lammie, C. M. Dickinson, and J. M. Roberts. "Evidence of Nonsusceptibihty to Diethylcarbamazine in Wucheria bancrofti." Journal of Infectious Diseases 163, no. 5 (May 1, 1991): 1157–60. http://dx.doi.org/10.1093/infdis/163.5.1157.

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29

Saraiva, Karina Lidianne Alcântara, Valdemiro Amaro Silva, Elisângela Santos Ferreira Dias, and Christina Alves Peixoto. "Morphological changes in the testis induced by diethylcarbamazine." Reproductive Toxicology 22, no. 4 (November 2006): 754–59. http://dx.doi.org/10.1016/j.reprotox.2006.07.008.

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30

Horton, John, and Thomas B. Nutman. "Albendazole Therapy for Loiasis Refractory to Diethylcarbamazine Treatment." Clinical Infectious Diseases 29, no. 3 (September 1999): 680–82. http://dx.doi.org/10.1086/598654.

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31

ILONDU, Ndidi, Orish Ebere ORISAKWE, Sabinus OFOEFULE, Onyenmechi Johnson AFONNE, Ejeatuluchukwu OBI, Kingsley Chisorom CHILAKA, and Chinna ORISH. "Pharmacokinetics of Diethylcarbamazine: Prediction by Concentration in Saliva." Biological & Pharmaceutical Bulletin 23, no. 4 (2000): 443–45. http://dx.doi.org/10.1248/bpb.23.443.

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32

&NA;. "Diethylcarbamazine vs ivermectin mass administration for lymphatic filariasis." Inpharma Weekly &NA;, no. 1593 (June 2007): 16. http://dx.doi.org/10.2165/00128413-200715930-00026.

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33

Awadzi, K., and HM Gilles. "Diethylcarbamazine in the treatment of patients with onchocerciasis." British Journal of Clinical Pharmacology 34, no. 4 (October 1992): 281–88. http://dx.doi.org/10.1111/j.1365-2125.1992.tb05632.x.

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34

Baveja, S. K., K. V. Ranga Rao, Rajinder Kumar, and K. Padmalatha Devi. "Sustained release tablet formulation of diethylcarbamazine. Part II." International Journal of Pharmaceutics 24, no. 2-3 (May 1985): 355–58. http://dx.doi.org/10.1016/0378-5173(85)90034-1.

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35

Baveja, S. K., K. V. Ranga Rao, and K. Padmalatha Devi. "Sustained release tablet formulation of diethylcarbamazine. Part III." International Journal of Pharmaceutics 27, no. 2-3 (December 1985): 157–62. http://dx.doi.org/10.1016/0378-5173(85)90065-1.

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36

Kitchen, Lynn W. "Diethylcarbamazine treatment of feline leukemia virus-infected cats." Veterinary Immunology and Immunopathology 53, no. 1-2 (September 1996): 191–92. http://dx.doi.org/10.1016/0165-2427(95)05522-3.

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37

Stenmark, K. R., M. L. Morganroth, L. K. Remigio, N. F. Voelkel, R. C. Murphy, P. M. Henson, M. M. Mathias, and J. T. Reeves. "Alveolar inflammation and arachidonate metabolism in monocrotaline-induced pulmonary hypertension." American Journal of Physiology-Heart and Circulatory Physiology 248, no. 6 (June 1, 1985): H859—H866. http://dx.doi.org/10.1152/ajpheart.1985.248.6.h859.

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We tested the hypothesis that monocrotaline would activate arachidonic acid metabolism in rats. If activation occurred before the pulmonary hypertension developed, arachidonate metabolites could play a role in the hypertensive monocrotaline injury. We found that 1 wk after monocrotaline administration 6-ketoprostaglandin F1 alpha and leukotriene C4 were increased in lung lavages. At 3 wk when pulmonary hypertension was well developed, lung lavage contained increased 6-ketoprostaglandin F1 alpha and thromboxane B2. In addition, the number and activity of white blood cells in the lavages was increased, and abnormal alveolar macrophages were present. The lung extract contained slow-reacting substances including leukotriene D4. Indomethacin administration inhibited the formation of cyclooxygenase metabolites but did not prevent pulmonary hypertension. Diethylcarbamazine administration reduced the numbers and activity of inflammatory cells, increased pulmonary hypertension, prevented right ventricular hypertrophy, and inhibited the formation of slow-reacting substances. We concluded that arachidonate metabolism was activated before pulmonary hypertension developed, that the inflammatory cells in the alveolus accompanied the hypertensive process, and that diethylcarbamazine attenuated both the monocrotaline-induced inflammatory response and the pulmonary hypertension.
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38

&NA;. "High microfilariae levels a risk factor for diethylcarbamazine ADRs." Reactions Weekly &NA;, no. 748 (April 1999): 5. http://dx.doi.org/10.2165/00128415-199907480-00011.

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39

Peixoto, C. A., L. C. Alves, F. A. Brayner, and M. S. Florêncio. "Diethylcarbamazine induces loss of microfilarial sheath of Wuchereria bancrofti." Micron 34, no. 8 (December 2003): 381–85. http://dx.doi.org/10.1016/s0968-4328(03)00099-4.

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40

Kitchen, L. "Diethylcarbamazine-related antimicrobial activity in Mycobacterium tuberculosis-infected blood." Journal of Antimicrobial Chemotherapy 42, no. 2 (August 1, 1998): 241–43. http://dx.doi.org/10.1093/jac/42.2.241.

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41

Orisakwe, O. E., N. D. A. Ilondu, O. J. Afonne, S. I. Ofoefule, C. N. Orish, and P. U. Agbasi. "Effect of Activated Charcoal on Diethylcarbamazine Absorption in Humans." American Journal of Therapeutics 8, no. 1 (January 2001): 7–9. http://dx.doi.org/10.1097/00045391-200101000-00003.

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42

Maizels, R. M., and D. A. Denham. "Diethylcarbamazine (DEC): immunopharmacological interactions of an anti-filarial drug." Parasitology 105, S1 (January 1992): S49—S60. http://dx.doi.org/10.1017/s0031182000075351.

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SUMMARYAnti-parasitic drugs may achieve their therapeutic effect either by direct activity against the pathogenic organism, or by altering host factors which lead to parasite killing. In this review, we discuss the evidence for an indirect mode of action for one major anti-filarial drug, diethylcarbamazine (DEC). The interpretation most consistent with existing data is that DEC alters arachidonic acid metabolism in microfilariae and in host endothelial cells. These changes may result in vasoconstriction and amplified endothelial adhesion leading to immobilization of microfilarial parasites, enhanced adherence and cytotoxic activity by host platelets and granulocytes. These events would represent activation of the innate, non-specific immune system, independent of the adaptive, antigen-specific, immune response. This model explains the paradox between rapid clearance in vivo and the lack of an in vitro effect, as well as the efficacy of DEC in non-immune animals.
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43

Rajan, T. V., Leonard D. Shultz, Subash Babu, John Doukas, Dale Greiner, and Pat Porte. "Diethylcarbamazine (DEC) Does Not Induce Nitric Oxide (NO) Synthesis." Experimental Parasitology 88, no. 3 (March 1998): 217–22. http://dx.doi.org/10.1006/expr.1998.4247.

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44

Vijayan, V. K., K. Sankaran, P. Venkatesan, and R. Prabhakar. "Effect of Diethylcarbamazine on the Alveolitis of Tropical Eosinophilia." Respiration 58, no. 5-6 (1991): 255–59. http://dx.doi.org/10.1159/000195941.

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45

Hamilton, Robert G., Elizabeth Wagner, Milton April, Jerry A. Winkelstein, Ann K. Sobotka, Eugene Bleeker, and N. Franklin Adkinson. "Dirofilaria immitis: Diethylcarbamazine-induced anaphylactoid reactions in infected dogs." Experimental Parasitology 61, no. 3 (June 1986): 405–20. http://dx.doi.org/10.1016/0014-4894(86)90197-9.

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46

Kanesa-thasan, Niranjan, Janice G. Douglas, and James W. Kazura. "Diethylcarbamazine inhibits endothelial and microfilarial prostanoid metabolism in vitro." Molecular and Biochemical Parasitology 49, no. 1 (November 1991): 11–19. http://dx.doi.org/10.1016/0166-6851(91)90125-p.

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47

Bach, Michael K., and John R. Brashler. "Inhibition of the leukotriene synthetase of rat basophil leukemia cells by diethylcarbamazine, and synergism between diethylcarbamazine and piriprost, a 5-lipoxygenase inhibitor." Biochemical Pharmacology 35, no. 3 (February 1986): 425–33. http://dx.doi.org/10.1016/0006-2952(86)90215-7.

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48

Ganesan, Senthil, Saurabh Galodha, and Rajan Saxena. "Retroperitoneal Cyst: An Uncommon Presentation of Filariasis." Case Reports in Surgery 2015 (2015): 1–3. http://dx.doi.org/10.1155/2015/674252.

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Primary retroperitoneal parasitic cysts are rare. Here we report about a middle aged male patient from rural north India with a recent onset of central abdominal retroperitoneal lump, pain, and fever. After surgical resection due to diagnostic uncertainty, at histopathology, it turned out be a filarial cyst. After receiving a course of diethylcarbamazine, the patient is asymptomatic at 4 months’ follow-up.
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49

Rizzo, J. Â., C. Belo, R. Lins, and G. Dreyer. "Children and adolescents infected withWuchereria bancroftiin Greater Recife, Brazil: a randomized, year-long clinical trial of single treatments with diethylcarbamazine or diethylcarbamazine–albendazole." Annals of Tropical Medicine & Parasitology 101, no. 5 (July 2007): 423–33. http://dx.doi.org/10.1179/136485907x176517.

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50

Weil, Gary J., K. V. P. Sethumadhavan, S. Santhanam, D. C. Jain, and T. K. Ghosh. "Persistence of Parasite Antigenemia Following Diethylcarbamazine Therapy of Bancroftian Filariasis." American Journal of Tropical Medicine and Hygiene 38, no. 3 (May 1, 1988): 589–95. http://dx.doi.org/10.4269/ajtmh.1988.38.589.

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