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Journal articles on the topic 'Differential Dissolution'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Loodts, V., H. Saghou, B. Knaepen, L. Rongy, and A. De Wit. "Differential Diffusivity Effects in Reactive Convective Dissolution." Fluids 3, no. 4 (2018): 83. http://dx.doi.org/10.3390/fluids3040083.

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When a solute A dissolves into a host fluid containing a reactant B, an A + B → C reaction can influence the convection developing because of unstable density gradients in the gravity field. When A increases density and all three chemical species A, B and C diffuse at the same rate, the reactive case can lead to two different types of density profiles, i.e., a monotonically decreasing one from the interface to the bulk and a non-monotonic profile with a minimum. We study numerically here the nonlinear reactive convective dissolution dynamics in the more general case where the three solutes can

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2

Yang, Xin, Xinrong Liu, Wanjun Zang, Zhiyong Lin, and Qiyun Wang. "A Study of Analytical Solution for the Special Dissolution Rate Model of Rock Salt." Advances in Materials Science and Engineering 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/4967913.

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By calculating the concentration distributions of rock salt solutions at the boundary layer, an ordinary differential equation for describing a special dissolution rate model of rock salt under the assumption of an instantaneous diffusion process was established to investigate the dissolution mechanism of rock salt under transient but stable conditions. The ordinary differential equation was then solved mathematically to give an analytical solution and related expressions for the dissolved radius and solution concentration. Thereafter, the analytical solution was fitted with transient dissolut

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Malakhov, V. V. "Stoichiography: New Ways Determining Chemical Composition and Real Structure of Materials." Eurasian Chemico-Technological Journal 3, no. 3 (2017): 141. http://dx.doi.org/10.18321/ectj557.

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The principles of stoichiography and novel reference-free methods of molecular and phase analysis for complex unknown mixtures are considered. The stoichiography can be inferred from stoichiometry of mass transfer of unsteady homo- and heterophase processes and joins both operations: separation of mixture by means of chromatography, electromigration, dissolution or others and determination of stoichiometry of a substance flow with time. The stoichiography allows a chemical compound to be determined by its primary property, namely, by stoichiometry of elemental composition. Stoichiograms provid

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Zhou, Cai Ju, Li Fang Li, Ying Liu, Shao Peng Wen, Yong En Guo та Xiao Guang Niu. "Study on the Inclusion Complex of Rutin/Sulfobutylether-β-Cyclodextrin". Advanced Materials Research 455-456 (січень 2012): 1177–81. http://dx.doi.org/10.4028/www.scientific.net/amr.455-456.1177.

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The inclusion complexes of rutin/sulfobutylether-β-cyclodextrin (SBE-β-CD) were prepared by grinding, co-precipitation and ultrasonic method and then identified with differential scanning calorimetry (DSC) and UV-visible spectrophotometry (UV). The molar ratio 1∶1 of rutin to SBE-β-CD in the complex was confirmed by phase solubility studies, and the dissolutions of rutin/SBE-β-CD were investigated by UV. The dissolution of rutin included in the complex showed significant increases in aqueous solution. The rutin/SBE-β-CD inclusion complex exhibited unique physical characteristics that are diffe

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5

Sharad, Kamble, and Shinde Sunita. "Studies on solubility enhancement of telmisartan by adsorption method." i-manager's Journal on Chemical Sciences 1, no. 1 (2019): 17. http://dx.doi.org/10.26634/jchem.1.1.16370.

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In this study precipitated form of Telmisartan was prepared by using Solvent evaporation technique and Spray drying technique. For this used adsorbents like Sylysia, Neusilin, and diluents like Lactose Monohydrate and Avicel. All these prepared batches were screened by performing Drug content, saturation solubility and dissolution study of the prepared batches. From this obtained optimized batch further characterized by using the dissolution test, Differential Scanning Calorimetry (DSC), X-Ray powder Diffractometer (XRD), and USP Dissolution test apparatus.

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Wang, Bo, Xinran Sun, Xu Guo, Hanxi Yi, and Zeneng Cheng. "Improvement of Resveratrol Solubility by Complexation with Lactose Using Organic Solvent Spray Drying Technique." Journal of Nanomaterials 2021 (October 6, 2021): 1–6. http://dx.doi.org/10.1155/2021/2886450.

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The purpose of this experiment is to change the crystallization state of resveratrol and improve its solubility and dissolution in water by spray drying technology, so as to improve the feasibility of resveratrol in clinical application. The powder samples were spray-dried with different proportions of ethanol aqueous solution as dissolution medium. The powder samples were characterized by infrared spectroscopy, thermogravimetry/differential scanning calorimetry, and ultraviolet spectroscopy, and their dissolution characteristics were investigated. It was found that the solubility and dissolut

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Patel, V. P., M. C. Gohel, and R K Parikh. "In Vitro Dissolution Enhancement of Felodipine." Indo Global Journal of Pharmaceutical Sciences 01, no. 02 (2011): 194–205. http://dx.doi.org/10.35652/igjps.2011.19.

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Purpose: With the introduction of combinatorial chemistry and high throughput screening, the properties of new chemical entities shifted towards higher molecular weight and increasing lipophilicity that results in decreasing aqueous solubility. It is not surprising that many drug candidates have poor water solubility since the initial selection of drug candidates are based on activity alone. Other physiochemical and biopharmaceutical properties such as permeability, biopharmaceutics and metabolism are rarely considered during the selection process. The aim of this study was to increase dissolu

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Choi, Min-Jong, Mi Ran Woo, Han-Gon Choi, and Sung Giu Jin. "Effects of Polymers on the Drug Solubility and Dissolution Enhancement of Poorly Water-Soluble Rivaroxaban." International Journal of Molecular Sciences 23, no. 16 (2022): 9491. http://dx.doi.org/10.3390/ijms23169491.

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The purpose of this study was to investigate the efficacy of hydrophilic polymers in a solid dispersion formulation in improving the solubility and dissolution rate of rivaroxaban (RXB), a poorly soluble drug. The developed solid dispersion consisted of two components, a drug and a polymer, and the drug was dispersed as amorphous particles in a polymer matrix using the spray drying method. Polymeric solid dispersions were evaluated using solubility tests, in vitro dissolution tests, powder X-ray diffraction, differential scanning calorimetry, scanning electron microscopy, and particle size dis

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9

Arif, Budiman, Nurlatifah Elis, and Amin Saeful. "Enhancement of Solubility and Dissolution Rate of Glibenclamide by Cocrystal Approach with Solvent Drop Grinding Method." International Journal of Current Pharmaceutical Review and Research 7, no. 5 (2016): 248–50. https://doi.org/10.5281/zenodo.12680579.

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Solubility is one of the physical properties of active substances that affect drug absorption after dissolved in thegastrointestinal tract. Drugs with a limited aqueous solubility show low bioavaibility and will affect dissolution as adetermine rate limiting step in the absorption process of the drug. Glibenclamide is antidiabetic which based on theBiopharmaceutical Classification System (BCS), has low solubility and high permeability which causes lowbioavailability. Cocrystallization is the process to enhance the physical properties of drugs, especially the solubility. Theresearch aimed to de

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10

Ketcham, Eric, and Neil G. Bennett. "Comparative Couple Stability: Same-sex and Male-female Unions in the United States." Socius: Sociological Research for a Dynamic World 5 (January 2019): 237802311982931. http://dx.doi.org/10.1177/2378023119829312.

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Findings on comparative couple stability between same-sex and male-female unions vary, with some studies finding similar dissolution rates among same-sex and male-female unions and others finding higher rates of dissolution among same-sex unions. The authors extend previous research by examining the association between gender composition of couples and dissolution patterns, distinguishing between cohabitational and formal unions. Using data from the How Couples Meet and Stay Together survey, a nationally representative longitudinal survey of coupled individuals including an oversample of gay-,

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Sushmita, Bala*1 Mukesh L. Shah2. "Impact Of Antisolvent Crystallization On Rate Of Dissolution Of Nifedipine." International Journal in Pharmaceutical Sciences 2, no. 1 (2024): 443–47. https://doi.org/10.5281/zenodo.10537527.

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Aim of the present study was to study the effect of the antisolvent method of crystallization/precipitation on the rate of dissolution using different antisolvent for nifedipine. Recrystallization of the drug was done in DMF, DMSO and ethanol using water as antisolvent. Drug Excipient Compatibility Study was confirmed by FTIR method. Differential scanning calorimetry (DSC) of pure drug and it’s solvates were done to confirm the crystalline structure of the and molecular symmetry was assured by XRD studies. Impact of the size of drug and it’s solvates n dissolution was confirmed by

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Dhokchawle, B. V., and A. B. Bhandari. "PREPARATION AND CHARACTERIZATION OF AMORPHOUS CEFUROXIME AXETIL." INDIAN DRUGS 50, no. 10 (2013): 53–61. http://dx.doi.org/10.53879/id.50.10.p0053.

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In the present study, amorphous form of cefuroxime axetil was prepared and characterized by various methods. The result showed that the amorphous form of cefuroxime axetil with hydrophilic carriers was successfully obtained by freeze drying. The amorphous form showed a substantially higher dissolution rate and saturation solubility than cefuroxime axetil and physical mixture. The molecular behaviour of the drug in all samples were characterized by X-ray powder diffraction, Fourier transformed infrared spectroscopy, scanning electron microscopy and differential scanning calorimetry. The dissolu

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13

MAHATO, HARI SHANKAR, and MICHAEL BÖHM. "An existence result for a system of coupled semilinear diffusion-reaction equations with flux boundary conditions." European Journal of Applied Mathematics 26, no. 2 (2014): 121–42. http://dx.doi.org/10.1017/s0956792514000369.

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In this paper, we consider diffusion, reaction and dissolution of mobile and immobile chemical species present in a porous medium. Inflow–outflow boundary conditions are considered at the outer boundary and the reactions amongst the species are assumed to be reversible which yield highly nonlinear reaction rate terms. The dissolution of immobile species takes place on the surfaces of the solid parts. Modelling of these processes leads to a system of coupled semilinear partial differential equations together with a system of ordinary differential equations (ODEs) with multi-valued right-hand si

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14

Gonzalez-Alvarez, Isabel, Marival Bermejo, Yasuhiro Tsume, et al. "An In Vivo Predictive Dissolution Methodology (iPD Methodology) with a BCS Class IIb Drug Can Predict the In Vivo Bioequivalence Results: Etoricoxib Products." Pharmaceutics 13, no. 4 (2021): 507. http://dx.doi.org/10.3390/pharmaceutics13040507.

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The purpose of this study was to predict in vivo performance of three oral products of Etoricoxib (Arcoxia® as reference and two generic formulations in development) by conducting in vivo predictive dissolution with GIS (Gastro Intestinal Simulator) and computational analysis. Those predictions were compared with the results from previous bioequivalence (BE) human studies. Product dissolution studies were performed using a computer-controlled multicompartmental dissolution device (GIS) equipped with three dissolution chambers, representing stomach, duodenum, and jejunum, with integrated transi

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15

Hu, Xinyu, and Xin Chen. "Optimisation of fertiliser dissolution under differential pressure tank during fertigation." Biosystems Engineering 206 (June 2021): 79–93. http://dx.doi.org/10.1016/j.biosystemseng.2021.03.016.

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16

Bryant, R. B., and J. Macedo. "Differential Chemoreductive Dissolution of Iron Oxides in a Brazilian Oxisol." Soil Science Society of America Journal 54, no. 3 (1990): 819–21. http://dx.doi.org/10.2136/sssaj1990.03615995005400030033x.

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17

Vasilyeva, I. G., V. V. Malakhov, L. S. Dovlitova, and H. Bach. "Composition characterization of Bi2Sr2CaCu2Ox single crystals by differential dissolution technique." Materials Research Bulletin 34, no. 1 (1999): 81–92. http://dx.doi.org/10.1016/s0025-5408(98)00207-4.

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18

Xie, Ming, Wei Yang, Mingzhu Zhao, et al. "Diagenetic Facies Controls on Differential Reservoir-Forming Patterns of Mixed Shale Oil Sequences in the Saline Lacustrine Basin." Minerals 13, no. 2 (2023): 143. http://dx.doi.org/10.3390/min13020143.

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The Permian Lucaogou Formation has developed mixed shale reservoirs, but there are few studies on the diagenetic facies, and the control effect of differential diagenesis on the reservoir capacity of shale oil reservoirs in this area is not clear. Therefore, shale samples of the Lucaogou Formation were systematically selected in this study, and through cast thin sections, field emission scanning electron microscopy, XRD mineral analysis, low-temperature nitrogen adsorption and high-pressure mercury injection experiments, the reservoir capacity of the shale oil reservoirs was evaluated from the

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19

Ahmadi, Shahram, Ali Shokuhfar, M. R. Abotalebi, and Arash Rezaei. "A Calorimetric Study on the Precipitation of T₁ Phase during the Ageing of an Al-Li-Cu-Zr Alloy." Defect and Diffusion Forum 273-276 (February 2008): 14–17. http://dx.doi.org/10.4028/www.scientific.net/ddf.273-276.14.

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The precipitation of T1 phase during the ageing of an Al- Li- Cu -Zr alloy sheet was studied by DSC (Differential Scanning Calorimetric) technique. Results showed that precipitation of T1 phase occurred in temperature range of 250°C to 300°C whereas its dissolution occurred within the temperature of 450°C to 530°C. Furthermore, activation energies for precipitation and dissolution of T1 phase were determined 122.1 kJ/mol and 130.3 kJ/mol, respectively.

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20

Zhao, W. W., J. Q. Gao, D. H. Liu, and Z. X. Li. "Study on the Thermodynamic Properties of Two Anti-Cancer Drugs." Advanced Materials Research 634-638 (January 2013): 1086–89. http://dx.doi.org/10.4028/www.scientific.net/amr.634-638.1086.

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The dissolution enthalpy of Cisplatin and Etoposide in the appropriate solvent were measured by RD496-2000 microcalorimeter under the conditions of atmospheric pressure and 309.65 K. The differential heat and the integral heat of the process are obtained, thereby establishing the relationship between the heat and the amount of solute, knowing that the dissolution process is the pseudo-first order reaction. In turn, the half-life, △solHm, △solGm, △solSm are also can obtained.

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Zaini, Erizal, Afriyani, Lili Fitriani, Friardi Ismed, Ayano Horikawa, and Hidehiro Uekusa. "Improved Solubility and Dissolution Rates in Novel Multicomponent Crystals of Piperine with Succinic Acid." Scientia Pharmaceutica 88, no. 2 (2020): 21. http://dx.doi.org/10.3390/scipharm88020021.

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The objectives of this study were to prepare and characterize a novel piperine–succinic acid multicomponent crystal phase and to evaluate the improvement in the solubility and dissolution rate of piperine when prepared in the multicomponent crystal formation. The solid-state characterization of the novel multicomponent crystal was performed by powder X-ray diffraction (XRD), differential scanning calorimetry (DSC), and Fourier transform-infrared (FT-IR) spectroscopy. Solubility and dissolution rate profiles were evaluated in distilled water. The physical stability was evaluated under high rela

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22

Karolewicz, Bożena, Karol Nartowski, Janusz Pluta, and Agata Górniak. "Physicochemical characterization and dissolution studies of acyclovir solid dispersions with Pluronic F127 prepared by the kneading method." Acta Pharmaceutica 66, no. 1 (2016): 119–28. http://dx.doi.org/10.1515/acph-2016-0008.

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Abstract The dissolution rate of anhydrous acyclovir was improved by the preparation of physical mixtures and solid dispersions with the non-ionic polymer Pluronic F127 using the kneading method at different drug-to-polymer ratios. The obtained physical mixtures and solid dispersions were examined in terms of drug content and possible physical and chemical interactions between the drug and polymer using FTIR spectral studies, differential scanning calorimetry and powder X-ray diffraction analysis. The dissolution rate of acyclovir was determined using the rotating disk method. It was found tha

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Zaini, Erizal, Salman Umar, and Nurhidayah Nurhidayah. "IMPROVEMENT OF DISSOLUTION RATE OF VALSARTAN BY SOLID DISPERSION SYSTEM USING D(−) MANNITOL." Asian Journal of Pharmaceutical and Clinical Research 10, no. 3 (2017): 288. http://dx.doi.org/10.22159/ajpcr.2017.v10i3.16171.

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ABSTRACTObjective: To improve dissolution rate of valsartan from solid dispersion system of valsartan and D(−) mannitol using co-grinding approach.Methods: Valsartan solid dispersion with different ratio of D(−) mannitol (1:1; 1:3 and 1: 5) were prepared by co-grinding method. Solid statecharacterization of the solid dispersion system was evaluated in term of crystallographic properties (powder X-ray diffraction), thermal behavior(differential scanning calorimetry [DSC]) and morphology (scanning electron microscope). The profile of dissolution rate was examined using USPdissolution apparatus t

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de, Melo Barbosa Raquel. "Development of solid dispersions of b-lapachone in PEG and PVP by solvent evaporation method." Drug Development and Industrial Pharmacy 44, no. 5 (2018): 750–56. https://doi.org/10.5281/zenodo.14780622.

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ABSTRACTb-lapachone (blap) has shown potential use in various medical applications. However, its poor solubility has limited its systemic administration and clinical applications. The aim of this work is to develop solid dispersions of blap using poly (ethylene glycol) (PEG 6000) and polyvinylpyrrolidone (PVP K30) as hydro- philic polymers and evaluate the dissolution rate in aqueous medium. Solid dispersions were prepared by solvent evaporation method using different weight ratios of blap and hydrophilic polymer (1:1, 1:2, and 1:3). Characterization performed by differential scanning calorime

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Kang, Yanhui, Fangyu Wang, Zeming Zhang, and Jinping Zhou. "Dissolution and Interaction of Cellulose Carbamate in NaOH/ZnO Aqueous Solutions." Polymers 13, no. 7 (2021): 1092. http://dx.doi.org/10.3390/polym13071092.

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The dissolution and molecular interactions of cellulose carbamate (CC) in NaOH/ZnO aqueous solutions were studied using optical microscopy, differential scanning calorimetry (DSC), 1H NMR, dynamic light scattering (DLS), atomic force microscopy (AFM), transmission electron microscopy (TEM), and molecular dynamic simulation. The dissolution of CC in NaOH/ZnO aqueous solutions using the freezing–thawing method was an exothermic process, and the lower temperature was favorable for the dissolution of CC. ZnO dissolved in NaOH aqueous solutions with the formation of Zn(OH)42−, and no free Zn2+ ions

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Riekes, Manoela, Gislaine Kuminek, Gabriela Rauber, Silvia Cuffini, and Hellen Stulzer. "Development and validation of an intrinsic dissolution method for nimodipine polymorphs." Open Chemistry 12, no. 5 (2014): 549–56. http://dx.doi.org/10.2478/s11532-014-0511-9.

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AbstractThe polymorphs of nimodipine, Modification I (Mod I), the metastable racemate, and Modification II (Mod II), the stable conglomerate, were evaluated by means of the intrinsic dissolution procedure. For this purpose, a hydro alcoholic solution (ethanol:water, 50:50, v/v) was selected as the dissolution medium, maintained at 37±0.5°C. Different rotation speeds were tested (50, 75 and 100 rpm) and the lower one was chosen for the test validation. Although the sample initially characterized as polymorph Mod I presented higher intrinsic dissolution rates in all the conditions tested, no sta

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Costa, Mayre Aparecida Borges da, Ana Lucia Vazquez Villa, Rita de Cássia da Silva Ascenção Barros, Eduardo Ricci-Júnior, and Elisabete Pereira dos Santos. "Development, characterization and evaluation of the dissolution profile of sulfasalazine suspensions." Brazilian Journal of Pharmaceutical Sciences 51, no. 2 (2015): 449–59. http://dx.doi.org/10.1590/s1984-82502015000200022.

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<p>This paper reports the development, characterization and <italic>in vitro</italic>dissolution behavior of sulfasalazine suspensions for treatment of chronic intestinal inflammatory diseases. Three formulations were developed, from powdered sulfasalazine obtained from different suppliers. The sulfasalazine was characterized regarding concentration, Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), X-Ray Diffraction (XRD), particle size distribution, polydispersion and solubility. The suspensions were developed and characterized regardi

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Li, Chengsong, Jie Fang, Feisheng Feng, Tingting Yao, Yongping Shan, and Wanli Su. "Differential Evolution in Hydrochemical Characteristics Amongst Porous, Fissured and Karst Aquifers in China." Hydrology 12, no. 7 (2025): 175. https://doi.org/10.3390/hydrology12070175.

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The efficacy of water resource management and protection hinges on a profound understanding of the controlling factors and regulatory mechanisms that shape groundwater chemistry within aquifers. Despite this, our comprehension of how groundwater chemistry and ion sources vary across diverse aquifer types remained limited. To bridge this gap, our study conducted a detailed hydrochemical and statistical investigation of porous, fissured, and karst aquifers. By applying multivariate statistical techniques, including principal component analysis (PCA) and hierarchical cluster analysis (HCA), the h

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Parmar, Komal, Mehul Patel, Kishorkumar Sorathia, and Tejal Soni. "Design and development of quetiapine fumarate nanosuspension by media milling method." Ars Pharmaceutica (Internet) 66, no. 1 (2024): 46–62. https://doi.org/10.30827/ars.v66i1.29818.

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Introduction: The critical and complex properties of Biopharmaceutics Classification System Class II quetiapine fumarate active pharmaceutical ingredient molecules that complicate effective oral delivery of these active pharmaceutical ingredients include low aqueous solubility and reduced bioavailability. Objective: The objective of this investigation is to develop a nanosuspension formulation of quetiapine fumarate using media milling techniques to effectively reduce particle size and enhance dissolution rate. Method: Quetiapine fumarate Nano suspensions were prepared by the media milling met

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Wagh, Vinod T., Ritu M. Gilhotra, and Rajendra D. Wagh. "Solid Dispersion (Kneading) Technique: A Platform for Enhancement Dissolution Rate of Valsartan Poorly Water Soluble Drug." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 11, no. 01 (2020): 20–24. http://dx.doi.org/10.25258/ijpqa.11.1.3.

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The objective of this study was to the enhancement of dissolution rate of Valsartan. Using a solid dispersion (kneading) method with Kollidon and Povidone K30 as a carrier. Eight different drugs: Carrier ratios were prepared. Using factorial design taking 3 factors i.e., the concentration of Valsartan (x1), Kollidon (x2), and Povidone K30(x3). The enhancement of dissolution depends on the amount of carrier and an increase in the concentration of carrier. Enhancement of dissolution rate depends on reduce particle size of drug place on the surface of carrier and increased wettability of drug par

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Shelake, S. S., R. G. Gaikwad, S. Patil, F. I. Mevekari, and S. Patil. "DEVELOPMENT OF SOLID DISPERSION TABLET OF CARVEDILOL TO IMPROVE SOLUBILITY." INDIAN DRUGS 53, no. 01 (2016): 54–59. http://dx.doi.org/10.53879/id.53.01.10330.

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Crystalline state compounds are typically dissolution rate limited and dissolution rate is directly proportional to the solubility for BCS class II or class IV compounds. Solid dispersions are one of the most promising strategies to improve the oral bioavailability poorly water soluble drugs. The purpose of this study was to increase solubility of carvedilol by solid dispersion (SDs) technique with Poloxamer (PXM) 407 in aqueous media. The carvedilol- PXM 407 solid dispersion was prepared by solvent evaporation, kneading and melting method. It was characterized by differential scanning calorim

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Radugin, Mikhail V., Tatiana N. Lebedeva, and Alexander N. Prusov. "DEPENDENCE OF DISSOLUTION ENTHALPY OF POLYVINYLPYRROLIDONE IN WATER ON ITS INITIAL MOISTURE CONTENT." IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENIY KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 59, no. 5 (2018): 27. http://dx.doi.org/10.6060/tcct.20165905.5304.

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Changes in integral and differential enthalpies of dissolution of polyvinylpyrrolidone (PVP) of different molecular weight in water were determined as a function of initial moisture content of the polymer. Hydration numbers were calculated.

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Latreche, Mansour, and Jean-François Willart. "Analysis of the Dissolution Mechanism of Drugs into Polymers: The Case of the PVP/Sulindac System." Pharmaceutics 15, no. 5 (2023): 1505. http://dx.doi.org/10.3390/pharmaceutics15051505.

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This paper is dealing with the dissolution mechanism of crystalline sulindac into amorphous Polyvinylpyrrolidone (PVP) upon heating and annealing at high temperatures. Special attention is paid on the diffusion mechanism of drug molecules in the polymer which leads to a homogeneous amorphous solid dispersion of the two components. The results show that isothermal dissolution proceeds through the growth of polymer zones saturated by the drug, and not by a progressive increase in the uniform drug concentration in the whole polymer matrix. The investigations also show the exceptional ability of t

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Wang, Jingmin, Denglin Han, Yuan Deng, et al. "Differential Characteristics and the Main Controlling Factors of Shale Oil Sweet Spot Reservoirs in Lucaogou Formation, Jimsar Sag, Junggar Basin." Geofluids 2022 (August 13, 2022): 1–19. http://dx.doi.org/10.1155/2022/6936161.

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The microscopic differences in characteristics and formation mechanism of shale oil reservoirs in the upper and lower sweet spot sections of the Lucaogou Formation in the Jimsar Depression, which has been identified as a national shale oil demonstration area in China, are still unclear. In this study, the characteristics and the main controlling factors of reservoir differences in different sweet spots of Lucaogou Formation were specified based on core observation, thin-section observation, X-ray diffraction, Rock-Eval, microscopic fluorescence of hydrocarbon inclusions, and temperature measur

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Hitendra, S. Mahajan. "Development and Evaluation of Rutin-HPβCD Inclusion Complex Based Mouth Dissolving Tablets". International Journal of Pharmaceutical Sciences and Developmental Research 3, № 1 (2018): 001–6. https://doi.org/10.17352/ijpsdr.000009.

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The objective of the present study was to explore inclusion complex of Rutin to improve the aqueous solubility and dissolution rate along with rapid mouth dissolving tablets for oral drug delivery. Rutin is a BCS class II drug having low aqueous solubility and therefore low oral bioavailability. In the present study, inclusion complex of rutin with hydroxypropyl-b-cyclodextrin were prepared by kneading method. Inclusion complex were characterized by 1H NMR, X-ray diffractometry (XRD), differential scanning calorimetry (DSC) studies, and Fourier transform infrared spectroscopy and evaluated for

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Fule, Ritesh A., Tarique S. Meer, Ajay R. Sav, and Purnima D. Amin. "Artemether-Soluplus Hot-Melt Extrudate Solid Dispersion Systems for Solubility and Dissolution Rate Enhancement with Amorphous State Characteristics." Journal of Pharmaceutics 2013 (April 4, 2013): 1–15. http://dx.doi.org/10.1155/2013/151432.

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This work studied artemether (ARTM) solid dispersion (SD) formulation using mixture of polymer excipient Soluplus, PEG 400, Lutrol F127, and Lutrol F68 melts at temperatures lower than the melting point of ARTM using a laboratory-size, single-screw rotating batch extruder. The effects of three surfactants PEG 400, Lutrol F127, and Lutrol F68 and parameters like mixing temperature, screw rotating speed, and residence time were systematically studied. SEM, XRD, and FT-IR were employed to investigate the evolution of ARTM’s dissolution into the molten excipient. Differential scanning calorimetry

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Sharma, Sanjay Kumar, and Rakesh P. Patel. "Enhancing the Solubility and Dissolution Rate of Meclizine Hydrochloride by Inclusion Complex." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 57–64. http://dx.doi.org/10.22270/jddt.v9i4.2981.

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Meclizine Hydrochloride is an Anti-Histamine drugs with very low bioavailability that can be improved by increasing its solubility and dissolution rate. The aim of this study is to enhance dissolution of Meclizine Hydrochloride as a model hydrophobic drug through application of inclusion complex technology. It was formulated as inclusion complex compact, and its dissolution property is evaluated and compared with marketed product of Meclizine Hcl tablet. The newly formulated drug and the interaction between excipients was examined by, Fourier-transform infrared spectroscopy, and differential s

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Al-Kazemi, Reham, Yacoub Al-Basarah, and Aly Nada. "Dissolution Enhancement of Atorvastatin Calcium by Cocrystallization." Advanced Pharmaceutical Bulletin 9, no. 4 (2019): 559–70. http://dx.doi.org/10.15171/apb.2019.064.

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Purpose: To enhance the dissolution rate of the poorly soluble drug atorvastatin calcium (ATC) bycocrystallization with selected coformers. Enhancement of the dissolution rate and solubility of thedrug, which is classified as Class II of the Biopharmaceutical Classification System (BCS), is expectedto enhance the bioavailability.Methods: Two methods were used for preparing the cocrystals, solvent drop grinding (SDG) andsolvent evaporation (SE) method using 1:1, 1:3, and 1:10 drug-coformer molar ratios. Glucosaminehydrochloride (GluN) and nicotinamide (NIC) were investigated as coformers. The c

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Ahmed, Md Faseehuddin, Kalpana Swain, Satyanarayan Pattnaik, and Biplab Kumar Dey. "Quality by Design Based Development of Electrospun Nanofibrous Solid Dispersion Mats for Oral Delivery of Efavirenz." Acta Chimica Slovenica 71, no. 1 (2024): 161–69. http://dx.doi.org/10.17344/acsi.2023.8538.

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Poor aqueous solubility often results in poor dissolution behavior and, consequently, poor bioavailability for those drugs whose intestinal absorption is dissolution rate limited. It is essential for formulation scientists to identify strategies to improve the solubility and dissolution rate of candidate drugs in order to improve their bioavailability. The present study investigated electrospun polymeric nanofibers for efavirenz (an antiretroviral drug), a Class II drug in the Biopharmaceutical Classification System. In order to fabricate nanofibers, hydrophilic spinnable polymer like Soluplus

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Varma, Mohan M., та Satish Kumar P. "Formulation and Evaluation of Gliclazide Tablets Containing PVP-K30 and Hydroxypropyl-β-cyclodextrin Solid Dispersion". International Journal of Pharmaceutical Sciences and Nanotechnology 5, № 2 (2012): 1706–19. http://dx.doi.org/10.37285/ijpsn.2012.5.2.6.

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Gliclazide is an anti-diabetic drug. It is a BCS class-II (poorly water soluble) drug and its bioavailability is dissolution rate limited. The dissolution rate of the drug was enhanced by using the solid dispersion technique. Solid dispersions were prepared using PVP-K30 (polyvinylpyrrolidone) and hydroxypropyl-β-cyclodextrin (HP BCD) as the hydrophilic carriers. The solid dispersions were characterized by using DSC (Differential scanning calorimetry), XRD (X-ray diffractometry) and FTIR (Fourier transform infrared spectroscopy). Solid dispersions were formulated into tablets. The formulated t

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Kapure, V. J., V. V. Pande, and P. K. Deshmukh. "Dissolution Enhancement of Rosuvastatin Calcium by Liquisolid Compact Technique." Journal of Pharmaceutics 2013 (February 27, 2013): 1–9. http://dx.doi.org/10.1155/2013/315902.

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In present investigation liquisolid compact technique is investigated as a tool for enhanced dissolution of poorly water-soluble drug Rosuvastatin calcium (RVT). The model drug RVT, a HMG-Co A reductase inhibitor was formulated in form of directly compressed tablets and liquisolid compacts; and studied for in-vitro release characteristics at different dissolution conditions. In this technique, liquid medications of water insoluble drugs in non-volatile liquid vehicles can be converted into acceptably flowing and compressible powders. Formulated systems were assessed for precompression paramete

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Patil, Payal H., Veena S. Belgamwar, Pratibha R. Patil, and Sanjay J. Surana. "Solubility Enhancement of Raloxifene Using Inclusion Complexes and Cogrinding Method." Journal of Pharmaceutics 2013 (January 29, 2013): 1–9. http://dx.doi.org/10.1155/2013/527380.

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The objective of the present work was to enhance the solubility and dissolution of practically water-insoluble drug raloxifene HCl (RLX), for the same two approaches that were used. In the first approach, drug was kneaded with hydroxypropyl-β-cyclodextrin (HPβCD), and in the second one drug was cogrinded with modified guar gum (MGG). The drug-cyclodextrin complex and drug-MGG cogrind mixtures were characterized by differential scanning calorimetry, X-ray diffraction studies, scanning electron microscopy, and Fourier transform infrared spectroscopy. The solubility and dissolution study reveals

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Nijhawan, Monika, Bhavana Jidige, Rajeswari Aleti, Sailaja Gunnam, and Trapti Saxena. "Development and characterization of voriconazole-oxalic acid dihydrate cocrystals for enhanced pharmaceutical performance." Prospects in Pharmaceutical Sciences 22, no. 4 (2025): 199–203. https://doi.org/10.56782/pps.278.

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Pharmaceutical cocrystallization is a promising alternative for improving the solubility and dissolution rate or manipulating other physical properties of active pharmaceutical ingredients. The objective of this investigation was to study the effect of cocrystallization to improve physicochemical properties of voriconazole (VZ). Liquid assisted grinding method was attempted for preparation of cocrystals. Melting point, Fourier transformation infrared spectroscopy (FTIR), powder X-ray diffraction (PXRD), and differential scanning calorimetry (DSC) techniques were employed to investigate the hyd

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Pai, H. C., Bikas C. Maji, A. Biswas, Madangopal Krishnan, and M. Sundararaman. "Calorimetric Studies of Dissolution Kinetics of Ni₂(Cr,Mo) Phase in Ni-Cr-Mo Alloys Using Non-Isothermal Approach." Defect and Diffusion Forum 279 (August 2008): 111–16. http://dx.doi.org/10.4028/www.scientific.net/ddf.279.111.

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The kinetics of dissolution of ordered phase with Pt2Mo structure has been studied in two nickel chromium alloys – one without molybdenum and another with molybdenum - using differential scanning calorimetry. The activation energy for dissolution, determined using three nonisothermal approaches was found to be ~ 418 kJ /mole for both the alloys. This value agreed very well with the activation energy for coarsening of g″ precipitates in Ni-Cr-Mo matrix and is close to activation energy for mobility of chromium and molybdenum in complex nickel alloy matrix.

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MASTEKAASA, ARNE. "Psychological Well-Being and Marital Dissolution." Journal of Family Issues 15, no. 2 (1994): 208–28. http://dx.doi.org/10.1177/0192513x94015002004.

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The low psychological well-being of the divorced and separated could be due to the hardships of the divorce process, more general problems of unmarried living, or differential selection for divorce. Using combined questionnaire and register data on 39,000 Norwegian men and women, it is shown that psychological well-being is a strong predictor of subsequent marital dissolution over a 2-to 4-year period. The strength of the relationship is particularly strong in the short run, but remains significant throughout the period of observation. The strong short-term relationship is most probably due to

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Lachkar-Zamouri, Olfa, Khemaies Brahim, Faten Bennour, and Ismail Khattech. "Dissolution of Tunisian phosphate ore by a mixture of sulfuric and phosphoric acid: Kinetics study by means of differential reaction calorimetry." Journal of Mining and Metallurgy, Section B: Metallurgy 55, no. 1 (2019): 9–19. http://dx.doi.org/10.2298/jmmb180808013l.

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A mixture of phosphoric and sulfuric acid was used to investigate the dissolution kinetics of phosphate ore by Differential Reaction Calorimetry (DRC). The effect of the solid-to-iquid ratio, concentration, stirring speed, particle size and temperature of the reaction is examined. It was established that the dissolution rate increased with stirring speed and particle size. However, rising the olid-to-iquid ratio, temperature and concentration decreased the dissolution rate. It was determined that the dissolution rate fits in the first order of the pseudo-homogeneous reaction model. Two negativ

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Imre, Silvia, Timea Haidu, Oana Ponta, Szende Vancea, Camil-Eugen Vari, and Amelia Tero-Vescan. "Internal Structure Quality Control of Solid Pharmaceuticals. A Comparative Study." Acta Medica Marisiensis 62, no. 1 (2016): 95–100. http://dx.doi.org/10.1515/amma-2015-0104.

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AbstractObjective: The aim of the study was a comparative investigation by spectral and thermal analysis in order to asses a number of characteristics of different varieties ofrawmaterials of ursodeoxycholic acid and ibuprofen. The different dissolution behavior of two ursodeoxycholic acid pharmaceutical product by crystallinity pattern was investigated. Methods: Raw materials of ursodeoxycholic acid and ibuprofen were used. IR spectroscopy, differential scanning calorimetry and X-Ray Diffraction Analysis were applied. Results: The results show no crystallinitydifferences for different batches

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Ivanov, Alexander A., Dmitri V. Alexandrov, and Irina V. Alexandrova. "Dissolution of polydisperse ensembles of crystals in channels with a forced flow." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 378, no. 2171 (2020): 20190246. http://dx.doi.org/10.1098/rsta.2019.0246.

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A non-stationary integro-differential model describing the dissolution of polydisperse ensembles of crystals in channels filled with flowing liquid is analysed. The particle-size distribution function, the particle flux through an arbitrary cross-section of the channel, the particle concentration profile, as well as the disappearance intensity of particles are found analytically. It is shown that a nonlinear behaviour of solutions is completely defined by the source term of particles introduced into the channel. In particular, the model approximately describes the processes of dissolution and

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Yucel, Deniz. "Wives’ Work Hours and Marital Dissolution: Differential Effects across Marital Duration." Sociology Mind 02, no. 01 (2012): 12–22. http://dx.doi.org/10.4236/sm.2012.21002.

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Orabi, Orabi H., and Amr S. Zaky. "Differential dissolution susceptibility of Paleocene foraminiferal assemblage from Farafra Oasis, Egypt." Journal of African Earth Sciences 113 (January 2016): 181–93. http://dx.doi.org/10.1016/j.jafrearsci.2015.11.004.

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