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Dissertations / Theses on the topic 'Differentiated function'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Harrington, Louise Susan. "The role of phospholipase C isoforms in regulated differentiated function in vascular smooth muscle." Thesis, Imperial College London, 2003. http://hdl.handle.net/10044/1/7562.

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2

Kukucka, Mark A. "Mechanisms by which hypoxia augments Leydig cell viability and differentiated cell function in vitro." Diss., Virginia Tech, 1993. http://hdl.handle.net/10919/38407.

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The 1980's heralded the discovery and identification of extra-pituitary sources of the neurohypophysial hormone oxytocin in non-neural tissues of several animal species. The presence, location and biosynthesis of significant amounts of oxytocin in the ovarian corpus luteum was followed by the immunocytochemical demonstration of an oxytocin-like peptide in the testicular interstitial cells. Leydig cells, which comprise up to 80% of the testicular intertubular cell population, are known to synthesize testosterone in situ. Indirect evidence indicated that an oxytocin-like peptide was also present

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3

Kukucka, Mark Anthony. "Mechanisms by which hypoxia augments Leydig cell viability and differentiated cell function in vitro /." This resource online, 1993. http://scholar.lib.vt.edu/theses/available/etd-06062008-170416/.

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4

Абакумов, Б. Р., та Р. М. Гриценко. "Апроксимація довільної диференційованої функції відрізками прямих". Thesis, Сумський державний університет, 2014. http://essuir.sumdu.edu.ua/handle/123456789/38800.

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В практичній діяльності ми постійно маємо справу з наближеними величинами, рівностями, формулами: будуємо за точками графіки, добуваємо корені з чисел, вирішуємо рівняння и т. д. В теорії наближених обчислень, яка в наші дні швидко розвивається, особливе значення мають методи, які застосовуються для розв’язання широкого класу математичних задач.

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5

O'Neill, Karla M. "Exploration of the potential roles of DNA methylation in controlling cellular function in human and mouse differentiated cells." Thesis, Ulster University, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.674741.

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DNA methylation has been implicated in a range of cellular processes such as X chromosome inactivation, imprinting, the silencing of developmentally important genes and in maintaining cellular viability. However, not all of these roles are equally well supported and much of the functional work has been done in mouse alone. I took advantage of a normal but immortalised human hTERT -1604 cell line to examine the effects of depleting the maintenance methyltransferase DNMTl and carried out comparative work in other cell lines and in mouse. Several studies reported increased microsatellite instabil

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Bloom, Carri-Ann. "The effects of terpenoids on the expression and function of cytokines and adipokines in pre-adipocytes and differentiated adipocytes." Thesis, Nelson Mandela Metropolitan University, 2017. http://hdl.handle.net/10948/9208.

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CURRENTLY UNDER EMBARGO UNTIL THE 26/4/2019: Type 2 diabetes is a metabolic disorder characterised by inflammation, insulin resistance and the inability of pancreatic β-cells to secrete enough insulin to produce a physiological effect. Obesity and high levels of triacylglycerol’s are associated with the development of Type 2 diabetes. Adipose tissue is an active endocrine organ that secretes various protein and peptide hormones, known as adipokines, which mediate important metabolic functions. In an insulin resistant and hyperglycaemic state, levels of anti-inflammatory adipokines, adiponectin

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7

Alrasheed, Maha Meshal. "Association of gene polymorphisms in thyroid function-related genes with differentiated thyroid cancer risk and post thyroidectomy l-thyroxine suppressive dose requirements." Thesis, University of Brighton, 2013. https://research.brighton.ac.uk/en/studentTheses/a70cf85d-a940-4ab0-8eff-51c3fb069d2d.

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Patients with differentiated thyroid cancer (DTC) are usually managed with total thyroidectomy and subsequent radioiodine ablation of the remnant thyroid tissue. Since these patients become athyrotic, L-throxine (L-T4) therapy is required for life, in order to replace the thyroid hormones and also to suppress the endogenous thyroid stimulating hormone (TSH) which may have a growth-promoting effect on any residual thyroid cancer cells. The approximate dose required to achieve this suppression is about 2 g/kg. However, there is wide variation between patients in their L-T4 requirement. Although

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8

Li, Yongguo [Verfasser], Martin [Akademischer Betreuer] Klingenspor, Hannelore [Akademischer Betreuer] Daniel, Michael [Akademischer Betreuer] Schemann, and Susanne [Akademischer Betreuer] Klaus. "Characterization of brown-like adipocytes differentiated in primary culture: thermogenic function, molecular basis of variation between strains and transcriptome analysis / Yongguo Li. Betreuer: Martin Klingenspor. Gutachter: Hannelore Daniel ; Michael Schemann ; Susanne Klaus ; Martin Klingenspor." München : Universitätsbibliothek der TU München, 2015. http://d-nb.info/1079655115/34.

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9

Fitzpatrick, Martin Antony. "Do differentiated macrophages display distinct metabolic profiles reflecting their different functions?" Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/7036/.

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Macrophages are key players in both regulatory and inflammatory immune responses. They are implicated in the pathogenesis of rheumatoid arthritis (RA) where they accumulate in the synovium and produce pro-inflammatory cytokines including TNFα and IL-6. The rheumatoid synovium is metabolically distinctive, with low oxygen perfusion and high concentrations of lactate and reactive oxygen species (ROS). Macrophages are known to respond to metabolic signals, therefore we wanted to explore whether metabolic phenotypes of differentiated macrophages could play a role in the persistence of RA. We used

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10

Katsura, Nagato. "Long-Term Culture of Primary Human Hepatocytes with Preservation of Proliferative Capacity and Differentiated Functions." Kyoto University, 2002. http://hdl.handle.net/2433/149354.

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11

Fiorelli, S. "BIOCHEMICAL AND FUNCTIONAL PROFILE OF SPONTANEOUSLY DIFFERENTIATED HUMAN MONOCYTE-DERIVED MACROPHAGES IN PATIENTS WITH ISCHEMIC HEART DISEASE." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/544434.

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Background: Atherosclerosis is a chronic inflammatory disease in which oxidative stress and macrophages play fundamental roles. Macrophages are heterogeneous cells in term of morphology and function and the prevalence of a specific morpho-phenotype may influence the progression or the regression of the plaque. Human coronary plaque macrophages are not easily obtainable and monocyte-derived macrophages (MDMs) are widely accepted as a good surrogate. Our previous study has reported that healthy subjects show two dominant MDM morphotypes, spindle and round, present in the same percentage. Aim: T

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12

Myre, Maxine. "Exploring the Independent and Combined Effects of Persistent Organic Pollutants and Hypoxia on Human Adipocyte Functions." Thèse, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/30416.

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Persistent organic pollutants (POPs) and adipose tissue hypoxia have been shown to independently affect adipocyte functions. The goals of this study were to (1) determine the effect of PCB-77, PCB-153, and DDE on the differentiation of human preadipocytes, and (2) investigate the cross-talk between PCB-77 and hypoxia in differentiated human adipocytes. First, human preadipocytes were exposed to PCB-77, PCB-153, or DDE during the entire 14-day differentiation period. We found no effect of low POP levels on lipid accumulation. Second, differentiated human adipocytes were exposed to a combination

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13

Gogusetti, Vivek Shashank Nag. "Functions of ATR Kinase in Terminally Differentiated Human Epidermal Keratinocyles and in Human Ex-Vivo Skin After Exposure to Ultraviolet B Radiation." Wright State University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=wright1622357540982634.

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14

Ciappuccini, Renaud. "Apport de l'imagerie fonctionnelle par TEMP/TDM et TEP/TDM dans la prise en charge des cancers différenciés de la thyroïde Incremental Value of a Dedicated Head and Neck Acquisition during 18F-FDG PET/CT in Patients with Differentiated Thyroid Cancer Full text links full-text provider logo Actions Favorites Share Page navigation Title & authors Abstract Conflict of interest statement Figures Similar articles Cited by References Related information LinkOut - more resources EJNMMI Res . 2018 Dec 3;8(1):104. doi: 10.1186/s13550-018-0461-x. Optimization of a dedicated protocol using a small-voxel PSF reconstruction for head-and-neck 18 FDG PET/CT imaging in differentiated thyroid cancer 78 Lymph node involvement in head-and-neck and thyroid cancers with digital PET/CT: the impact of ultra-high definition voxels and point-spread function Tumor burden of persistent disease in patients with differentiated thyroid cancer: correlation with postoperative risk-stratification and impact on outcome 133 18F-Fluorocholine PET/CT is a highly sensitive but poorly specific tool for identifying malignancy in thyroid nodules with indeterminate cytology: The Chocolate study PSMA expression in neovasculature of persistent/recurrent differentiated thyroid cancerin the neck: relationship with radioiodine uptake, 18Fluorodeoxyglucose avidity and outcome." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMC424.

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L’imagerie scintigraphique des cancers thyroïdiens différenciés (CTD) présente la particularité d’utiliser deux radiopharmaceutiques, l’iode 131 (131I) et le 18-Fluorodésoxyglucose (18FDG). La fixation de ces traceurs dépend habituellement du degré de différenciation et de l’agressivité de la tumeur. L’objectif de ce travail était d’étudier l’apport de différents aspects techniques et d’instrumentation, à savoir l’imagerie hybride par TEMP/TDM et TEP/TDM, la point-spread function (PSF), la taille des voxels et la technologie TEP digitale, et d’explorer si d’autres traceurs TEP pouvaient présen

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15

Lizée, Marie-Hélène. "Diversité, organisation spatiale et fonctionnelle des communautés de papillons (lépidoptères, rhopalocères) en milieu urbain et périurbain : Rôle des espaces artificialisés en terme de conservation et de connectivité." Thesis, Aix-Marseille 1, 2011. http://www.theses.fr/2011AIX10153.

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Au regard de la variété d’enjeux (économiques, sociétaux et environnementaux) que recouvrent les espaces de nature soumis au développement humain, il apparait urgent de comprendre les déterminants de leur fonctionnement. En effet, même si elles ne constituent pas des lieux prioritaires de conservation pour les espèces rares et menacées, les zones urbanisées sont loin d’être dépourvues de biodiversité. Cependant, cette biodiversité et les processus écologiques en œuvre demeurent mal connus. Il s’agit ici d’utiliser les communautés de Rhopalocères (papillons de jour) comme grille de lecture des

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16

Bian, Weining. "Tissue Engineering of a Differentiated Skeletal Muscle Construct with Controllable Structure and Function." Diss., 2011. http://hdl.handle.net/10161/3812.

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<p>Transplantation of a functional engineered skeletal muscle substitute is a promising therapeutic option to repair irreversible muscle damage, and, on the other hand, functional muscle tissue constructs can serve as in vitro 3D tissue models that complement the conventional 2D cell cultures and animal models to advance our limited understanding of intrinsic myogenesis and muscle regeneration process. However, the engineering of skeletal muscle constructs with comparable contractile function to the native muscle is hampered by the lack of 1) effective and reproducible methods to form relative

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17

Chi, Kun-Ting, and 紀昆廷. "The Role of Sirtuin 3 and Mitochondria in the Function of Adipocytes Differentiated from Human Mesenchymal Stem Cells." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/03501116923857735044.

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碩士<br>國立陽明大學<br>生化暨分子生物研究所<br>100<br>It has been established that mitochondrial biogenesis plays a critical role during adipogenesis and in mature adipocytes. Abundant evidence has been accumulated to indicate that mitochondrial dysfunction in adipocytes is associated with type 2 diabetes. However, the role that mitochondrial dysfunction plays in the pathogenesis of type 2 diabetes remains to be elucidated. In this study, the role of Sirtuin 3 (SIRT3) and mitochondria in the function of adipocytes differentiated from adipose tissue-derived human mesenchymal stem cells were investigated. I

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18

Staecker, Jeffrey Lee. "Maintenance of some differentiated functions in rat hepatocytes in cell culture by butyrate." 1987. http://catalog.hathitrust.org/api/volumes/oclc/17337711.html.

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Thesis (Ph. D.)--University of Wisconsin--Madison, 1987.<br>Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

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19

Chin, Chia-Hsuan, and 金家宣. "Functional Characterization of Nicotinic Receptors in diButyryl cAMP-Differentiated SH-SY5Y Neuroblastoma." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/23519684857857054087.

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碩士<br>國立陽明大學<br>神經科學研究所<br>95<br>Abstract Nicotinic acetylcholine receptors (nAch receptors) play an important role in nervous system. nAch receptors are distributed over not only the peripheral nervous system also the central nervous system, and they have many functions in the nervous system. First, nAch receptors are permeable for cations, like Na+ and Ca2+, and produce the action potential while binding with neurotransmitters. Second, nAch receptors on the presynaptic terminal can increase the release of neurotransmitters and the mRNA expression of some genes. Third, nAch receptors can

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20

Lu, Hsing-Tsen, and 盧幸岑. "Transcriptional regulation and functional characterization of P2X4 receptors in the retinoic acid-differentiated N2a neuroblastoma cells." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/55671365166804541174.

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碩士<br>國立陽明大學<br>神經科學研究所<br>96<br>P2X4 receptor is one of the most abundant ATP receptors in the brain but its expression during neuronal differentiation and the transcriptional regulatory mechanisms remain unclear. The purpose of this study is to characterize mechanisms involving in P2X4 receptor expression of the retinoic acid (RA)-differentiated N2a neuroblastoma cells. Our results revealed that all-trans retinoic acid (atRA) induced the process less naïve N2a neuroblastoma cells differentiation into process bearing neuron-like cells. Interestingly, the differentiation was associated with a

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