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Journal articles on the topic 'Differentiating therapy'

Author: Grafiati

Published: 29 March 2025

Last updated: 31 July 2025

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1

Mauss, Stefan, Juergen Stechel, Reinhard Willers, Guenther Schmutz, Florian Berger, and Werner O. Richter. "Differentiating hyperlipidaemia associated with antiretroviral therapy." AIDS 17, no. 2 (2003): 189–94. http://dx.doi.org/10.1097/00002030-200301240-00008.

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Akita, Sadanori, Keiji Suzuki, Hiroshi Yoshimoto, Akira Ohtsuru, Akiyoshi Hirano, and Shunichi Yamashita. "Cellular Mechanism Underlying Highly-Active or Antiretroviral Therapy-Induced Lipodystrophy: Atazanavir, a Protease Inhibitor, Compromises Adipogenic Conversion of Adipose-Derived Stem/Progenitor Cells through Accelerating ER Stress-Mediated Cell Death in Differentiating Adipocytes." International Journal of Molecular Sciences 22, no. 4 (2021): 2114. http://dx.doi.org/10.3390/ijms22042114.

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Lipodystrophy is a common complication in human immunodeficiency virus (HIV)-infected patients receiving highly active antiretroviral therapy (HAART) or antiretroviral therapy (ART). Previous studies demonstrated that endoplasmic reticulum (ER) stress-mediated unfolded protein response (UPR) is involved in lipodystrophy; however, the detailed mechanism has not been fully described in human adipogenic cell lineage. We utilized adipose tissue-derived stem cells (ADSCs) obtained from human subcutaneous adipose tissue, and atazanavir (ATV), a protease inhibitor (PI), was administered to ADSCs and

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Waheed, Zeeshan, Muhammad Irfan, Mohammad Salih, and Ali Bin Sarwar Zubairi. "Differentiating Asthma from its mimics." Chest Disease Reports 1, no. 1 (2011): e17. http://dx.doi.org/10.4081/cdr.1.191.

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All that wheezes is not asthma this adage accredited to Chevalier Jackson emphasizes the importance of differentiating asthma from its mimics, particularly if the patient is not responding to usual therapy. The above statement also warrants further diagnostic evaluation and management of non-asthma conditions that mimic asthma. We present here a case of a middle aged female who presented with severe bronchospasm, initially labeled as asthma but was resistant to usual anti-asthma therapy. After further workup she was eventually diagnosed to have esophageal achalasia.

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Waheed, Zeeshan, Muhammad Irfan, Mohammad Salih, and Ali Bin Sarwar Zubairi. "Differentiating Asthma from its mimics." Chest Disease Reports 1, no. 1 (2011): 17. http://dx.doi.org/10.4081/cdr.2011.e17.

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<em>All that wheezes is not asthma</em> this adage accredited to Chevalier Jackson emphasizes the importance of differentiating asthma from its mimics, particularly if the patient is not responding to usual therapy. The above statement also warrants further diagnostic evaluation and management of non-asthma conditions that mimic asthma. We present here a case of a middle aged female who presented with severe bronchospasm, initially labeled as asthma but was resistant to usual anti-asthma therapy. After further workup she was eventually diagnosed to have esophageal achalasia.

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Danielian, Alfred, and Ankit B. Shah. "Differentiating Physiology from Pathology." Clinics in Sports Medicine 41, no. 3 (2022): 425–40. http://dx.doi.org/10.1016/j.csm.2022.02.005.

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Lin, Tara L., William Matsui, Milada S. Vala, Sarah Brennan, B. Douglas Smith, and Richard J. Jones. "Anti-Leukemic Effect of Maintenance Chemotherapy Is Mediated by Induction of Differentiation." Blood 106, no. 11 (2005): 865. http://dx.doi.org/10.1182/blood.v106.11.865.865.

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Abstract The clinical benefit of maintenance therapy (prolonged post-remission low-dose therapy) has been limited to two diseases, acute lymphocytic leukemia (ALL) and acute promyelocytic leukemia (APL), despite extensive study in many malignancies. Moreover, the mechanisms responsible for the anti-leukemic effects of maintenance therapy in both ALL and APL are unclear. Maintenance therapy in ALL consists of the low-dose cytotoxic agents methotrexate (MTX) and 6-mercaptopurine (6MP), while maintenance therapy in APL has primarily been all-trans-retinoic acid (ATRA). Interestingly, the addition

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Cassinat, Bruno, Sylvie Chevret, Fabien Zassadowski, et al. "In vitro all-trans retinoic acid sensitivity of acute promyelocytic leukemia blasts: a novel indicator of poor patient outcome." Blood 98, no. 9 (2001): 2862–64. http://dx.doi.org/10.1182/blood.v98.9.2862.

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Abstract Acute promyelocytic leukemia (APL) blasts possess a unique sensitivity to the differentiating effects of all-transretinoic acid (ATRA). Multicenter trials confirm that the combination of differentiation and cytotoxic therapy prolongs survival in APL patients. However relapses still occur, and exquisite adaptation of therapy to prognostic factors is essential to aim at a possible cure of the disease. A heterogeneity was previously reported in the differentiation rate of patients' APL blasts, and it was postulated that this may reflect the in vivo heterogeneous outcome. In this study, i

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Mehrazin, Reza, and Matthew D. Galsky. "Systemic therapy—differentiating the achievable from the achieved." Nature Reviews Urology 12, no. 3 (2015): 128–29. http://dx.doi.org/10.1038/nrurol.2014.358.

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9

Callens, Celine, Séverine Coulon, Jerome Naudin, et al. "Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia." Journal of Experimental Medicine 207, no. 4 (2010): 731–50. http://dx.doi.org/10.1084/jem.20091488.

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Differentiating agents have been proposed to overcome the impaired cellular differentiation in acute myeloid leukemia (AML). However, only the combinations of all-trans retinoic acid or arsenic trioxide with chemotherapy have been successful, and only in treating acute promyelocytic leukemia (also called AML3). We show that iron homeostasis is an effective target in the treatment of AML. Iron chelating therapy induces the differentiation of leukemia blasts and normal bone marrow precursors into monocytes/macrophages in a manner involving modulation of reactive oxygen species expression and the

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10

Dadheech, Nidheesh, Sanket Soni, Abhay Srivastava, et al. "A Small Molecule Swertisin fromEnicostemma littoraleDifferentiates NIH3T3 Cells into Islet-Like Clusters and Restores Normoglycemia upon Transplantation in Diabetic Balb/c Mice." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–20. http://dx.doi.org/10.1155/2013/280392.

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Aim. Stem cell therapy is one of the upcoming therapies for the treatment of diabetes. Discovery of potent differentiating agents is a prerequisite for increasing islet mass. The present study is an attempt to screen the potential of novel small biomolecules for their differentiating property into pancreatic islet cells using NIH3T3, as representative of extra pancreatic stem cells/progenitors.Methods. To identify new agents that stimulate islet differentiation, we screened various compounds isolated fromEnicostemma littoraleusing NIH3T3 cells and morphological changes were observed. Character

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11

Martire, Joseph R. "Differentiating Stress Fracture From Periostitis." Physician and Sportsmedicine 22, no. 10 (1994): 71–81. http://dx.doi.org/10.1080/00913847.1994.11710503.

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Gobbi, Giuliana, Prisco Mirandola, Cecilia Carubbi та ін. "Phorbol ester–induced PKCϵ down-modulation sensitizes AML cells to TRAIL-induced apoptosis and cell differentiation". Blood 113, № 13 (2009): 3080–87. http://dx.doi.org/10.1182/blood-2008-03-143784.

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AbstractDespite the relevant therapeutic progresses made in these last 2 decades, the prognosis of acute myeloid leukemia (AML) remains poor. Phorbol esters are used at very low concentrations as differentiating agents in the therapy of myeloid leukemias. Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL), in turn, is a death ligand that spares normal cells and is therefore currently under clinical trials for cancer therapy. Emerging evidence, however, suggests that TRAIL is also involved in nonapoptotic functions, like cell differentiation. PKCϵ is differentially modulated along

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13

Gribble, Phillip A. "Evaluating and Differentiating Ankle Instability." Journal of Athletic Training 54, no. 6 (2019): 617–27. http://dx.doi.org/10.4085/1062-6050-484-17.

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Given the prevalence of lateral ankle sprains during physical activity and the high rate of reinjury and chronic ankle instability, clinicians should be cognizant of the need to expand the evaluation of ankle instability beyond the acute time point. Physical assessments of the injured ankle should be similar, regardless of whether this is the initial lateral ankle sprain or the patient has experienced multiple sprains. To this point, a thorough injury history of the affected ankle provides important information during the clinical examination. The physical examination should assess the talocru

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Kamdar, Forum, Mohammad Nurulqadr Jameel, Paul Score, and Jianyi Zhang. "Cellular therapy promotes endogenous stem cell repair." Canadian Journal of Physiology and Pharmacology 90, no. 10 (2012): 1335–44. http://dx.doi.org/10.1139/y2012-115.

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Cellular transplantation for cardiac repair has emerged as an exciting treatment option for patients with myocardial infarction (MI) and heart failure. Animal models of post-infarction left ventricular remodeling have demonstrated an improvement in left ventricular (LV) function, decrease in scar size, and amelioration of adverse cardiac remodeling after stem cell transplantation. These beneficial effects occur despite minimal engraftment and negligible differentiation of transplanted cells. Evidence of the heart capability to self-renew continues to mount; however, the extent to which this oc

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Kornitzer, Jeffrey, Hael F. Abdulrazeq, Mohammad Zaidi, et al. "Differentiating Flail Limb Syndrome From Amyotrophic Lateral Sclerosis." American Journal of Physical Medicine & Rehabilitation 99, no. 10 (2020): 895–901. http://dx.doi.org/10.1097/phm.0000000000001438.

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Park, Hyo Eun, Donghee Kim, Hyun Sook Koh, Sungbo Cho, Jung-Suk Sung, and Jae Young Kim. "Real-Time Monitoring of Neural Differentiation of Human Mesenchymal Stem Cells by Electric Cell-Substrate Impedance Sensing." Journal of Biomedicine and Biotechnology 2011 (2011): 1–8. http://dx.doi.org/10.1155/2011/485173.

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Stem cells are useful for cell replacement therapy. Stem cell differentiation must be monitored thoroughly and precisely prior to transplantation. In this study we evaluated the usefulness of electric cell-substrate impedance sensing (ECIS) forin vitroreal-time monitoring of neural differentiation of human mesenchymal stem cells (hMSCs). We cultured hMSCs in neural differentiation media (NDM) for 6 days and examined the time-course of impedance changes with an ECIS array. We also monitored the expression of markers for neural differentiation, total cell count, and cell cycle profiles. Cellular

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17

Arkhipov, S. A., E. D. Mangazeeva, V. V. Arkhipova, A. P. Bogachuk, V. M. Lipkin, and A. I. Autenshlyus. "The effect of the acetyl-amide form of the synthetic peptide HLDF-6 on the CDH2 and CD24 expression in breast cancer." Сибирский научный медицинский журнал 45, no. 3 (2025): 97–103. https://doi.org/10.18699/ssmj20250310.

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The development and research of drugs capable of reducing the malignancy of tumors is one of the most promising areas in the differentiation therapy of breast cancer (BC). As the full-size differentiation factor (HLDF) significantly contributes to enhancing the differentiation level of invasive breast carcinoma cells of a non-specific type, it can be considered as a promising tool for differentiating therapy of BC. The disadvantage of full-size HLDF is its rapid biodegradation in the body. In this regard, the acetyl-amide form of the peptide (HLDF-6) was synthesized to protect against hydrolys

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18

Horn, Linda B. "Differentiating Between Vestibular and Nonvestibular Balance Disorders." Neurology Report 21, no. 1 (1997): 23–28. http://dx.doi.org/10.1097/01253086-199721010-00006.

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Hatton, Jennifer L., та Lisa D. Yee. "Clinical Use of PPARγLigands in Cancer". PPAR Research 2008 (2008): 1–13. http://dx.doi.org/10.1155/2008/159415.

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The role of PPARγin adipocyte differentiation has fueled intense interest in the function of this steroid nuclear receptor for regulation of malignant cell growth and differentiation. Given the antiproliferative and differentiating effects of PPARγligands on liposarcoma cells, investigation of PPARγexpression and ligand activation in other solid tumors such as breast, colon, and prostate cancers ensued. The anticancer effects of PPARγligands in cell culture and rodent models of a multitude of tumor types suggest broad applicability of these agents to cancer therapy. This review focuses on the

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Ferrero, Dario, Benedetto Bruno, Patrizia Pregno, et al. "Combined differentiating therapy for myelodysplastic syndromes: A phase II study." Leukemia Research 20, no. 10 (1996): 867–76. http://dx.doi.org/10.1016/0145-2126(95)00156-5.

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21

Prashad, Sacha L., Leylah Drusbosky, Hassan Sibai, et al. "Ex Vivo High-Throughput Flow Cytometry Screening Identifies Subsets of Responders to Differentiation Agents in Individual AML Patient Samples." Blood 128, no. 22 (2016): 5206. http://dx.doi.org/10.1182/blood.v128.22.5206.5206.

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Abstract Background: Prognoses for acute promyelocytic leukemia (APL) patients improved drastically upon the introduction of differentiation therapy with all-trans-retinoic acid (ATRA) in combination with conventional chemotherapy. Unfortunately, this therapeutic approach has not translated to other genetic subtypes of acute myeloid leukemia (AML) where patients demonstrate marked heterogeneity to differentiating agents. To provide improved detection of drug-induced differentiation in AML patients, we have developed a high-throughput, flow cytometry-based personalized medicine platform. Method

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Medhat, Dalia, Clara I. Rodríguez, and Arantza Infante. "Immunomodulatory Effects of MSCs in Bone Healing." International Journal of Molecular Sciences 20, no. 21 (2019): 5467. http://dx.doi.org/10.3390/ijms20215467.

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Mesenchymal stem cells (MSCs) are capable of differentiating into multilineage cells, thus making them a significant prospect as a cell source for regenerative therapy; however, the differentiation capacity of MSCs into osteoblasts seems to not be the main mechanism responsible for the benefits associated with human mesenchymal stem cells hMSCs when used in cell therapy approaches. The process of bone fracture restoration starts with an instant inflammatory reaction, as the innate immune system responds with cytokines that enhance and activate many cell types, including MSCs, at the site of th

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23

Prime, Morgane, J. Lucas McKay, Allison A. Bay, et al. "Differentiating Parkinson Disease Subtypes Using Clinical Balance Measures." Journal of Neurologic Physical Therapy 44, no. 1 (2020): 34–41. http://dx.doi.org/10.1097/npt.0000000000000297.

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24

Guillaume, Daniel J., and Su-Chun Zhang. "Human embryonic stem cells: a potential source of transplantable neural progenitor cells." Neurosurgical Focus 24, no. 3-4 (2008): E3. http://dx.doi.org/10.3171/foc/2008/24/3-4/e2.

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✓ The primary therapeutic goal of embryonic stem cell (ESC) research is cell replacement therapy. During the last decade, great strides have been made in developing in vitro protocols for differentiating human ESCs into neuroepithelial progenitors. More recent progress has been made in further directing them into becoming cells with specialized regional and neurotransmitter identities, such as midbrain dopaminergic and spinal motor neurons. Along with directed differentiation, other current efforts are aimed at efficient enrichment, avoidance of immune rejection, demonstration of functional in

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25

Ferguson, Bruce. "The Importance of Bian Zheng (Pattern Differentiation) in TCVM." American Journal of Traditional Chinese Veterinary Medicine 3, no. 1 (2008): 67–69. https://doi.org/10.59565/fzsp4218.

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Bian Zheng is a system of Pattern Differentiation unique to TCVM used to make a TCVM diagnosis. Bian Zheng is not equivalent to a Western Biomedical diagnosis. A canine clinical case of inflammatory bowel disease is used as an example of differentiating between Bian Zheng and Western Biomedical diagnosis. Treating a disease which was non-responsive to conventional Western therapy on the basis of Bian Zheng led to a complete resolution of clinical signs and a positive outcome. The approach to making the correct Bian Zheng is discussed.

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ATSTUPĖNAITĖ, Vaida, Algidas BASEVIČIUS, Adrijus KRIMELIS, Artūras INČIŪRA, and Daiva VAITKIENĖ. "Diffusion-weighted magnetic resonance imaging of cervical cancer." Acta medica Lituanica 18, no. 4 (2011): 139–46. http://dx.doi.org/10.6001/actamedica.v18i4.1866.

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Background. Diffusion-weighted magnetic resonance imaging (DW–MRI) has been employed in the diagnostics of malignant tumors of abdomen and pelvis relatively recently. Nowadays, there exists a particular interest in adaptation DW–MRI for assessing the response of tumors to chemoradiaton therapy. The aim of our study was to compare the mean value of the apparent diffusion coefficient (ADC) in a healthy cervix, cancer-affected cervix and a cervix after chemoradiation therapy, as well as to identify the ADC range typical of cervical cancer. Materials and methods. The study enrolled 108 female pati

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Kemp, Erika L., and Jeffrey L. Crabtree. "Differentiating Fieldwork Settings: Matching Student Characteristics to Demands." Occupational Therapy In Health Care 32, no. 3 (2018): 216–29. http://dx.doi.org/10.1080/07380577.2018.1491084.

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Ghila, Luiza, Yngvild Bjørlykke, Thomas Aga Legøy та ін. "Bioinformatic Analyses of miRNA–mRNA Signature during hiPSC Differentiation towards Insulin-Producing Cells upon HNF4α Mutation". Biomedicines 8, № 7 (2020): 179. http://dx.doi.org/10.3390/biomedicines8070179.

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Mutations in the hepatocyte nuclear factor 4α (HNF4α) gene affect prenatal and postnatal pancreas development, being characterized by insulin-producing β-cell dysfunction. Little is known about the cellular and molecular mechanisms leading to β-cell failure as result of HNF4α mutation. In this study, we compared the miRNA profile of differentiating human induced pluripotent stem cells (hiPSC) derived from HNF4α+/Δ mutation carriers and their family control along the differentiation timeline. Moreover, we associated this regulation with the corresponding transcriptome profile to isolate transcr

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Takahashi, Nobushige, Osamu Takahashi, Ryosuke Ushijima, Rie Umebayashi, and Junji Nishikawa. "A Tip for Differentiating Between Sensory and Muscle Action Potentials." American Journal of Physical Medicine & Rehabilitation 96, no. 12 (2017): e228. http://dx.doi.org/10.1097/phm.0000000000000749.

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Cañal-Bruland, Rouwen, Merel Mooren, and Geert J. P. Savelsbergh. "Differentiating Experts' Anticipatory Skills in Beach Volleyball." Research Quarterly for Exercise and Sport 82, no. 4 (2011): 667–74. http://dx.doi.org/10.1080/02701367.2011.10599803.

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Koeffler, H. Phillip. "Is there a role for differentiating therapy in non-APL AML?" Best Practice & Research Clinical Haematology 23, no. 4 (2010): 503–8. http://dx.doi.org/10.1016/j.beha.2010.09.014.

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Schlough, Kathleen, Kerryn Andre, Marley Owen, et al. "Differentiating Between Idiopathic Toe Walking and Cerebral Palsy." Pediatric Physical Therapy 32, no. 1 (2020): 2–10. http://dx.doi.org/10.1097/pep.0000000000000659.

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Wettasinghe, M. C., S. Perera, and N. D. Wickramasinghe. "Pulmonary artery filling defects - Not all are pulmonary emboli." Sri Lanka Journal of Medicine 32, no. 2 (2023): 82–84. http://dx.doi.org/10.4038/sljm.v32i2.418.

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Differentiating pulmonary artery sarcoma from pulmonary artery emboli is challenging since the clinical presentation and imaging features of both conditions are often similar. Timely differentiation of the two conditions is important as delayed diagnosis often results in the progression of pulmonary artery sarcoma leading to poor prognosis and unnecessary anticoagulant therapy. We describe a case of a middle-aged male, who was initially diagnosed with pulmonary embolism, but later diagnosed with a pulmonary artery sarcoma. The case report emphasizes the importance of early imaging findings, wh

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Tampin, B., K. Briffa, and H. Slater. "Differentiating nociceptive and neuropathic components of clinical pain presentations matters!" Manual Therapy 25 (September 2016): e52. http://dx.doi.org/10.1016/j.math.2016.05.069.

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Ogrodniczuk, John S., William E. Piper, Anthony S. Joyce, et al. "Differentiating Symptoms of Complicated Grief and Depression among Psychiatric Outpatients." Canadian Journal of Psychiatry 48, no. 2 (2003): 87–93. http://dx.doi.org/10.1177/070674370304800204.

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Objective: This study examined whether dimensions of complicated grief (CG) could be distinguished from dimensions of depression and whether these dimensions were differentially affected by group psychotherapy for CG. Method: A total of 398 psychiatric outpatients who had experienced one or more significant death losses provided ratings on standard measures of grief and depression. Factor analysis of the 56 items from these measures was used to explore the possibility that grief and depression symptoms would form separate dimensions of distress. Subsamples of the patients also participated in

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LYDEN, KATE, DINESH JOHN, PHILIPPA DALL, and MALCOLM H. GRANAT. "Differentiating Sitting and Lying Using a Thigh-Worn Accelerometer." Medicine & Science in Sports & Exercise 48, no. 4 (2016): 742–47. http://dx.doi.org/10.1249/mss.0000000000000804.

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ROSS, GWYNETH B., BRITTANY DOWLING, NIKOLAUS F. TROJE, STEVEN L. FISCHER, and RYAN B. GRAHAM. "Objectively Differentiating Movement Patterns between Elite and Novice Athletes." Medicine & Science in Sports & Exercise 50, no. 7 (2018): 1457–64. http://dx.doi.org/10.1249/mss.0000000000001571.

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Berkowska, Klaudia, Aoife Corcoran, Małgorzata Grudzień, et al. "Investigating the Role of VDR and Megalin in Semi-Selectivity of Side-Chain Modified 19-nor Analogs of Vitamin D." International Journal of Molecular Sciences 20, no. 17 (2019): 4183. http://dx.doi.org/10.3390/ijms20174183.

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1,25-dihydroxyvitamin D3 (1,25D3) is implicated in many cellular functions, including cell proliferation and differentiation, thus exerting potential antitumor effects. A major limitation for therapeutic use of 1,25D3 are potent calcemic activities. Therefore, synthetic analogs of 1,25D3 for use in anticancer therapy should retain cell differentiating potential, with calcemic activity being reduced. To obtain this goal, the analogs should effectively activate transcription of genes responsible for cell differentiation, leaving the genes responsible for calcium homeostasis less active. In order

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Mathur, Ankit, and Daman Saluja. "Abstract 264: Differentiation therapy: Esculetin as a potent agent to alter cellular plasticity of leukemic & solid tumor stem cells." Cancer Research 84, no. 6_Supplement (2024): 264. http://dx.doi.org/10.1158/1538-7445.am2024-264.

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Abstract Background The “Differentiation therapy” has been emerging as a promising and more effective strategy against acute leukemia relapses. Objective In extension to the revolutionising therapeutic outcomes of All Trans Retinoic Acid (ATRA) to induce terminal differentiation of Acute Promyelocytic Leukemic (APL) blast cells, we decipher the potential effect of a natural compound “Esculetin” to serve as a differentiating agent in Acute Myeloid Leukemia (AML) as well as solid tumour cells. Underlaying role of Wnt signaling pathways in esculetin mediated blast cell differentiation was also ev

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Chou, Chung-Hsing, Hueng-Chuen Fan, and Dueng-Yuan Hueng. "Potential of Neural Stem Cell-Based Therapy for Parkinson’s Disease." Parkinson's Disease 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/571475.

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Neural stem cell (NSC) transplantation is an emerging strategy for restoring neuronal function in neurological disorders, such as Parkinson’s disease (PD), which is characterized by a profound and selective loss of nigrostriatal dopaminergic (DA) neurons. Adult neurogenesis generates newborn neurons that can be observed at specialized niches where endothelial cells (ECs) play a significant role in regulating the behavior of NSCs, including self-renewal and differentiating into all neural lineage cells. In this minireview, we highlight the importance of establishing an appropriate microenvironm

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Khatoonabadi, Ahmad Reza, Mahshid Aghajanzadeh, Saman Maroufizadeh, Zahra Vahabi, and Armin Safaeian. "Developing a Persian Verbal Fluency Test and Comparing the Results Between Healthy Persian Speakers and Persian Speakers Patients With Alzheimer Disease and Mild Cognitive Impairment." Iranian Rehabilitation Journal 19, no. 4 (2021): 387–98. http://dx.doi.org/10.32598/irj.19.4.1518.1.

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Objectives: Phonemic and semantic fluency tasks are used for verbal fluency (VF) evaluation. The present study aimed to select the most appropriate semantic categories and the most frequent phonemes of Persian as items for the VF test. Then, we determine the test results in differentiation between cognitively intact people and those with Mild Cognitive Impairment (MCI) and Alzheimer Disease (AD). Methods: A cross-sectional study was conducted on 120 people (60 cognitively intact, 30 with AD, and 30 with MCI) in two phases. In phase one, linguists determine the most frequent phonemes at the beg

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Molinaro, Alessandro, Daniela Zanta, Maria Luisa Moleti, et al. "Challenging management of severe differentiation syndrome in pediatric acute promyelocytic leukemia treated with ATRA/ATO." Mediterranean Journal of Hematology and Infectious Diseases 14, no. 1 (2022): e2022027. http://dx.doi.org/10.4084/mjhid.2022.027.

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The ATRA/ATO combination treatment of acute promyelocytic leukemia (APL) represents a paradigm of successful targeted and chemotherapy-free treatment in oncology. This therapeutic strategy is aimed at sparing patients from chemotherapy toxicity, while maintaining an excellent survival with a low risk of relapse. Main induction treatment-related complications are differentiation syndrome (DS) and hyperleukocytosis, which is related to DS and its severity. In the period December 2019 – December 2020, 8 children with newly diagnosed APL underwent induction therapy with ATRA/ATO in our center. In

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Zhang, Zhenqing, Yunli Jia, Xiaoniu Miao, et al. "Abstract 6115: Development of functionally differentiating anti-CD73 antibodies for cancer therapy." Cancer Research 82, no. 12_Supplement (2022): 6115. http://dx.doi.org/10.1158/1538-7445.am2022-6115.

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Abstract Background: Although the discovery and development of first-generation of immune checkpoint inhibitors (towards PD1 and CTLA-4) was a major milestone for cancer therapy, current clinical response rates are still considered very limited. Combination treatments are predicted to improve on these current immunotherapies including the targeting of the adenosine pathway (CD39, CD73 or A2AR), which has shown a lot of promise in preclinical and early clinical studies. CD73 is an ecto-5′-nucleotidase which transforms adenosine monophosphate (AMP) to adenosine. Adenosine is a soluble immunosupp

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Ahmed, Mariyam, Henny Alice Westra, and Michael J. Constantino. "Early therapy interpersonal process differentiating clients high and low in outcome expectations." Psychotherapy Research 22, no. 6 (2012): 731–45. http://dx.doi.org/10.1080/10503307.2012.724538.

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Oktar, Nezih, Tayfun Dalbasti, and Berna Yilmaz. "Local therapy of recurrent anaplastic gliomas with a differentiating agent of bucladesine." Clinical Neurology and Neurosurgery 99 (July 1997): S230. http://dx.doi.org/10.1016/s0303-8467(97)82344-x.

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Dadfarmay, Sina, Robert Berkowitz, Bernard Kim, and Rama Bindu Manchikalapudi. "Differentiating Pulmonary Arterial and Pulmonary Venous Hypertension and the Implications for Therapy." Congestive Heart Failure 16, no. 6 (2010): 287–91. http://dx.doi.org/10.1111/j.1751-7133.2010.00192.x.

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Oreshkina, Yelena Vladimirovna. "TO THE ISSUE OF DIFFERENTIATING THE NOTIONS «ART THERAPY» AND «ART PEDAGOGY»." Вестник Восточно-Сибирского государственного института культуры 144 (November 28, 2022): 123–31. http://dx.doi.org/10.31443/2541-8874-2022-3-23-123-131.

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Kolhe, Kailash, and Vishal Sharma. "Editorial: Differentiating Gastrointestinal Tuberculosis and Crohn's Disease—Antitubercular Therapy, Corticosteroids or Both." Journal of Gastrointestinal Infections 12, no. 01 (2022): 009–10. http://dx.doi.org/10.1055/s-0042-1757398.

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Granlund, Mats, Patrik Arvidsson, Anna Niia, et al. "Differentiating Activity and Participation of Children and Youth with Disability in Sweden." American Journal of Physical Medicine & Rehabilitation 91 (February 2012): S84—S96. http://dx.doi.org/10.1097/phm.0b013e31823d5376.

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Robinson, Jeffery R. "Lower Extremity Pain of Lumbar Spine Origin: Differentiating Somatic Referred and Radicular Pain." Journal of Manual & Manipulative Therapy 11, no. 4 (2003): 223–34. http://dx.doi.org/10.1179/106698103790825519.

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