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1

McGraw, Tim E. "Denoising, segmentation and visualization of diffusion weighted MRI." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0011618.

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2

Gaige, Terry A. (Terry Alden) 1981. "Complex muscle architecture described with diffusion weighted MRI." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/39867.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2007.<br>Includes bibliographical references (p. 89-98).<br>The complex array of fiber orientations exhibited by muscles such as the tongue, esophagus, and heart, enable function beyond basic pulling. Among other things, the presence of crossing geometry adds the ability to push by bi-directional contraction causing expansion in the orthogonal direction. Diffusion weighted magnetic resonance imaging (DW-MRI), provides a convenient, non-destructive, method for deriving fiber architecture in many tissues. DW-M
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Mosavi, Firas. "Whole-Body MRI including Diffusion-Weighted Imaging in Oncology." Doctoral thesis, Uppsala universitet, Enheten för radiologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-209777.

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Cancer is one of the major causes of worldwide mortality. Imaging plays a vital role in the staging, follow-up, and evaluation of therapeutic response in cancer patients. Whole-body (WB) magnetic resonance imaging (MRI), as a non-ionizing imaging technique, is a promising procedure to assess tumor spreading in a single examination. New MRI technological developments now enable the application of diffusion-weighted imaging (DWI) of the entire body. DWI reflects the random motion of water molecules and provides functional information of body tissues. DWI can be quantified with the use of the app
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4

Blackledge, Matthew David. "Assessing response in bone metastases using diffusion weighted MRI." Thesis, University of London, 2012. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.548045.

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5

Dhital, Bibek. "Characterizing Brain White Matter with Diffusion-Weighted Magnetic Resonance." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-180140.

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It has been known for almost two decades that the water proton NMR signal of diffusing water molecules in brain white matter undergoes a non-monoexponential decay with increasing diffusion gradient factor b. With the help of numerical simulations and analytical expressions, much effort has been directed to describing the signal decay and to extracting relevant biophysical features of the system under investigation. However, the physical basis of such nonmonoexponential behavior is still not properly understood. The primary difficulty in characterizing this phenomenon is the variation in behav
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6

Wilm, Bertram Jakob. "Diffusion-weighted MRI : volume selection, field monitoring and image reconstruction /." [S.l.] : [s.n.], 2009. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=18318.

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7

Schob, Stefan, Jonas Meyer, Matthias Gawlitza, et al. "Diffusion-weighted MRI reflects proliferative activity in primary CNS lymphoma." Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-210909.

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Purpose: To investigate if apparent diffusion coefficient (ADC) values within primary central nervous system lymphoma correlate with cellularity and proliferative activity in corresponding histological samples. Materials and Methods: Echo-planar diffusion-weighted magnetic resonance images obtained from 21 patients with primary central nervous system lymphoma were reviewed retrospectively. Regions of interest were drawn on ADC maps corresponding to the contrast enhancing parts of the tumors. Biopsies from all 21 patients were histologically analyzed. Nuclei count, total nuclei area and average
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8

McHugh, Damien Joseph. "The effect of tumour microstructure on diffusion-weighted MRI measurements." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/the-effect-of-tumour-microstructure-on-diffusionweighted-mri-measurements(9821717e-df69-4dd0-baf7-51cf27a18aa2).html.

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By sensitising the magnetic resonance signal to the diffusion of water molecules in tissue, diffusion-weighted magnetic resonance imaging provides a means of assessing tumour microstructure non-invasively. Such measurements have the potential to provide important information about tumour development and the response of tumours to treatment, but the way in which different tissue properties affect the diffusion-weighted signal remains unclear. Through simulations, in vivo studies and phantom experiments, this thesis investigates the relationship between the diffusion-weighted signal, the pulse s
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9

Nguyen, Huyen Thanh. "Dynamic Contrast-Enhanced MRI and Diffusion-Weighted MRI for the Diagnosis of Bladder Cancer." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1365176629.

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10

Sahalan, Mariaulpa. "Diffusion-weighted Imaging of Lymph Node Tissue." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/20070.

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Purpose: The study investigates the hypothesis of clinically observed decreased apparent diffusion coefficient (ADC) of cancerous lymph nodes can be attributed to increased cellularity. The study characterises the mean diffusivity (MD) of lymph node sub-structures and investigates correlation between MD and cellularity metrics. The study also investigates the theoretical information content of single and multi-biophysical models. Methods:. A 3 mm diameter core sample was extracted from a formalin fixed lymph node tissue post-surgery and imaged using 9.4T and 16.4T Bruker MRI system. Samples
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11

Niinimäki, J. (Jaakko). "Diffusion-weighted MRI and delayed contrast enhancement of degenerated intervertebral disc." Doctoral thesis, University of Oulu, 2009. http://urn.fi/urn:isbn:9789514291715.

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Abstract Magnetic resonance imaging (MRI) provides methods to study the microstructure and functional properties of tissues that can be utilized to acquire information about the degenerative processes in the spine. The purpose of the current study was to evaluate the value of diffusion-weighted MRI and quantification of delayed gadolinium enhancement in assessing intervertebral disc degeneration. An experimental degeneration model was used to evaluate the sensitivity of diffusion-weighted MRI and T2 relaxation time measurements in detecting early degenerative changes in the disc. In six pigs,
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12

Hosey, Timothy Peter. "Inference of heterogeneous nerve fibre structure from diffusion weighted MRI scans." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614155.

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13

Graham, Mark. "The development and application of a simulation system for diffusion-weighted MRI." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10047351/.

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Diffusion-weighted MRI (DW-MRI) is a powerful, non-invasive imaging technique that allows us to infer the structure of biological tissue. It is particularly well suited to the brain, and is used by clinicians and researchers studying its structure in health and disease. High quality data is required to accurately characterise tissue structure with DW-MRI. Obtaining such data requires the careful optimisation of the image acquisition and processing pipeline, in order to maximise image quality and minimise artefacts. This thesis extends an existing MRI simulator to create a simulation system cap
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Hillergren, Pierre. "Towards non-invasive Gleason grading of prostate cancer using diffusion weighted MRI." Thesis, Umeå universitet, Institutionen för fysik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-172808.

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Prostate cancer is one of the most common cancer diagnosis in men. This project aimed to help in characterization and treatment planning of prostate cancer by producing a Gleason grading probability based on apparent diffusion coefficient (ADC). In a study, from which this project received the patient data, the patients were first imaged using magnetic resonance imaging (MRI) in a 3T positron emission tomography MRI (PET/MRI) scanner. The prostates were surgically removed and placed in a patient specific mold. While inside the mold, the prostates were imaged using the same scanner, producing e
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Theilmann, Rebecca Jean. "High-resolution diffusion imaging with DIFRAD-FSE (diffusion-weighted radial acquisition with fast spin echo) MRI." Diss., The University of Arizona, 2001. http://hdl.handle.net/10150/284332.

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A novel MRI method, DIFRAD-FSE (D̲i̲f̲fusion with R̲adial A̲cquisition of D̲ata with F̲ast S̲pin-E̲cho) is presented that enables rapid, high-resolution, multi-shot diffusion-weighted MRI without significant artifacts due to motion. Following a diffusion-weighted spin-echo preparation, multiple radial lines of Fourier data are acquired using spin-echo refocusing. Data can be acquired in either 2D or 3D Fourier space. Motion correction is accomplished via one of four correction techniques: phase correction, shift correction, a combination of the phase and shift correction, or magnitude. Images
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Kokkonen, S. M. (Salla-Maarit). "MRI of intracranial tumours in adults:oedema-attenuated inversion recovery MR sequence in low-field MRI, diffusion-weighted MRI and BOLD fMRI." Doctoral thesis, University of Oulu, 2009. http://urn.fi/urn:isbn:9789514292316.

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Abstract The goal of this study was to explore preoperative evaluation of patients with intracranial tumours using magnetic resonance imaging (MRI) methods: oedema-attenuated inversion recovery (EDAIR) sequence in low-field MRI, and diffusion-weighted imaging (DWI) and resting-state functional MRI (fMRI) in high-field MRI. The aim was also to increase our knowledge about the effects of brain surgery on eloquent brain cortices using new MRI techniques. The total number of patients in these studies was 50 (24 women). Enhancement of the tumour in ten patients after intravenous administration of
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17

Mott, Lisa. "Efficient statistical methods for inference and model selection in diffusion-weighted MRI models." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/31173/.

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Diffusion-Weighted Magnetic Resonance Imaging (DW-MRI) on the brain is a revolutionary method that provides in-vivo access to tissue macrostructure non-invasively (Basser et al., 1994). Recently, DW-MRI has been shown to have great potential in characterising brain microstructure, such as diameter and size distribution of neuronal fibres, features that were available so far only postmortem or through animal studies (Zhang et al., 2011). Using a process known as Tractography the existence of brain connections can be estimated using a set of DW images (Basser et al., 2000). The main aim of this
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18

Morgado, Correia Marta. "Development of methods for the acquisition and analysis of diffusion weighted MRI data." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611789.

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19

Chatterjee, Aritrick. "Redefining the biophysical basis of contrast in diffusion-weighted MRI of the prostate." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/15400.

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Purpose: The study investigates the hypothesis that the clinically observed decrease in ADC with increasing prostate cancer Gleason grade can be attributed to an increasing volume of low diffusivity epithelial cells, and corresponding decreasing volumes of higher diffusivity stroma and lumen space, rather than increased cell density. Methods: Whole human prostates and tissue cores were imaged post radical prostatectomy on 9.4T and 16.4T Bruker MRI systems respectively. Digital histology images were analysed andDWI measurements were correlated with regions of interest in the prostate specimens
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20

Novello, Lisa. "Towards Improving the Specificity of Human Brain Microstructure Research with Diffusion-Weighted MRI." Doctoral thesis, Università degli studi di Trento, 2022. http://hdl.handle.net/11572/342277.

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The possibility to perform virtual, non-invasive, quantitative, in vivo histological assessments might revolutionize entire fields, among which clinical and cognitive neurosciences. Magnetic Resonance Imaging (MRI) is an ideal non-invasive imaging technique to achieve these goals. Tremendous advancements in the last decades have favored the transition of MRI scanners from “imaging devices” to “measurement devices” (Novikov, 2021), thus capable to yield measurements in physical units, which might be further combined to provide quantities describing histological properties of substrates. A centr
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21

Kanao, Shotaro. "Differentiating benign and malignant inflammatory breast lesions: Value of T2 weighted and diffusion weighted MR images." Kyoto University, 2019. http://hdl.handle.net/2433/236592.

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22

Frost, Stephen Robert. "Diffusion-weighted magnetic resonance imaging with readout-segmented echo-planar imaging." Thesis, University of Oxford, 2012. https://ora.ox.ac.uk/objects/uuid:94421cdc-6bcb-49c2-b9d9-64e016b875f8.

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Diffusion-weighted (DW) magnetic resonance imaging is an important neuroimaging technique that has successful applications in diagnosis of ischemic stroke and methods based on diffusion tensor imaging (DTI). Tensor measures have been used for detecting changes in tissue microstructure and for non-invasively tracing white matter connections in vivo. The most common image acquistion strategy is to use a DW single-shot echo-planar imaging (ss-EPI) pulse sequence, which is attractive due to its robustness to motion artefacts and high imaging speed. However, this sequence has limited achievable spa
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23

Wu, Ona. "Predictive models of tissue outcome in acute human cerebral ischemia using diffusion and perfusion weighted MRI." Thesis, Massachusetts Institute of Technology, 2002. http://hdl.handle.net/1721.1/8358.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2002.<br>Includes bibliographical references.<br>Diffusion (DWI) and perfusion weighted (PWI) magnetic resonance imaging (MRI) provide significant insight into acute stroke and can potentially be useful for clinical decision-making. In particular, current therapeutic decisions for acute human cerebral ischemia are typically based on time of symptom onset, limiting the number of patients treated. Imaging, however, offers insight into the physiologic integrity of brain tissue that is not
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Harkins, Kevin. "BIOPHYSICAL MECHANISMS OF DIFFUSION WEIGHTED MRI ASSESSED THROUGH COMPUTATIONAL MODELING AND EXPERIMENTS IN BIOREACTOR CELL CULTURES." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/195985.

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The apparent diffusion coefficient (ADC) is a quantitative measure of water diffusion in tissue which is sensitive to the microstructural features of brain tissue and can be measured non-invasively with diffusion-weighted MRI (DWMRI). Within minutes after the onset of ischemic stroke, the ADC of water decreases 30-50% within the affected tissue. Although this was initially discovered nearly two decades ago, there is no consensus on the biophysical mechanisms responsible for the drop in ADC after ischemia. This dissertation investigates the biophysical mechanisms which determine the ADC through
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25

Stahle, Jessica Anne. "Diffusion Weighted MR Imaging in the Differentiation between Metastatic and Benign Lymph Nodes in Canine Patients with Head and Neck Disease." Thesis, Virginia Tech, 2016. http://hdl.handle.net/10919/86612.

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In dogs with large primary tumors, regional lymph node involvement or evidence of distant metastasis can have worse prognoses and significantly decreased survival. Lymph node size alone has been shown to be insufficient as a predictor for the accurate clinical staging of some canine neoplasia, including oral malignant melanoma. However, regional lymph nodes of the oral cavity, such as the medial retropharyngeal lymph nodes, are difficult to access for routine sampling. Diffusion weighted magnetic resonance imaging (DWI) has demonstrated the ability to differentiate metastatic from inflammator
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Ohno, Ayami. "The comparison of high-resolution diffusion weighted imaging (DWI) with high-resolution contrast-enhanced MRI in the evaluation of breast cancers." Kyoto University, 2020. http://hdl.handle.net/2433/259003.

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27

Jepsen, Peter Austin. "Improvements in Diffusion Weighted Imaging Through a Composite Body and Insert Gradient Coil System." BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/3700.

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Diffusion Magnetic Resonance Imaging (DMRI) is a class of Magnetic Resonance Imaging (MRI) techniques with broad medical applications ranging from characterization of tumors and brain damage to potential prediction of stroke. Gradient coil and signal-to- noise ratio (SNR) constraints limit spatial resolution, accuracy, and scan time in DMRI. Achieving high b-values (measures of a scan's sensitivity to diffusion) often require scans with long diffusion gradient pulses, leading to significant magnetic resonance (MR) signal decay before the signal can be sampled. This signal loss reduces the accu
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Briody, Ashleigh. "Retrospective Evaluation of Diffusion Weighted MRI Imaging of Head and Neck Cancers and the Correlation with Histopathology." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu150296320276419.

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Kerttula, L. (Liisa). "Magnetic resonance imaging of the intervertebral disc:post-traumatic findings and the value of diffusion-weighted MR imaging." Doctoral thesis, University of Oulu, 2001. http://urn.fi/urn:isbn:9514264711.

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Abstract Magnetic resonance imaging (MRI) provides important information about structural and biochemical changes in organs. MRI is also an effective imaging method for the evaluation of spinal disorders. However, many of its potential applications - particularly diffusion imaging - have not yet been thoroughly explored. The purpose of this study was to determine the MRI-detectable changes in the intervertebral disc after trauma and to test the feasibility of diffusion-weighted MR imaging of the intervertebral discs. A minipig model was used in the experimental study to determine the MRI c
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LAPUCCI, CATERINA. "ADVANCED SUSCEPTIBILITY AND DIFFUSION WEIGHTED IMAGING IN THE DIAGNOSIS OF MULTIPLE SCLEROSIS: FROM RESEARCH TO CLINICAL APPLICATIONS." Doctoral thesis, Università degli studi di Genova, 2022. http://hdl.handle.net/11567/1088218.

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Rational and Objectives In 2015, the Institute of Medicine described the need to study the phenomenon of misdiagnosis as a “moral, professional, and public health imperative”. Despite the periodic updates of diagnostic criteria for MS, the risk of diagnosing as having MS patients with other disease involving the Central Nervous System (CNS) remains still not negligible. Indeed, diagnosis of MS may be straightforward, but a rapid and accurate diagnosis of MS can also be an issue, particularly due to the lack of specific biomarkers. Alongside developments that enabled earlier diagnosis of MS
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Metwalli, Nader. "High angular resolution diffusion-weighted magnetic resonance imaging: adaptive smoothing and applications." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/34854.

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Diffusion-weighted magnetic resonance imaging (MRI) has allowed unprecedented non-invasive mapping of brain neural connectivity in vivo by means of fiber tractography applications. Fiber tractography has emerged as a useful tool for mapping brain white matter connectivity prior to surgery or in an intraoperative setting. The advent of high angular resolution diffusion-weighted imaging (HARDI) techniques in MRI for fiber tractography has allowed mapping of fiber tracts in areas of complex white matter fiber crossings. Raw HARDI images, as a result of elevated diffusion-weighting, suffer from de
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Maiwald, Bettina, Donald Lobsien, Thomas Kahn, and Patrick Stumpp. "Is 3-Tesla Gd-EOB-DTPA-enhanced MRI with diffusion-weighted imaging superior to 64-slice contrast-enhanced CT for the diagnosis of hepatocellular carcinoma?" Universitätsbibliothek Leipzig, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-155190.

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Objectives: To compare 64-slice contrast-enhanced computed tomography (CT) with 3-Tesla magnetic resonance imaging (MRI) using Gd-EOB-DTPA for the diagnosis of hepatocellular carcinoma (HCC) and evaluate the utility of diffusion-weighted imaging (DWI) in this setting. Methods: 3-phase-liver-CT was performed in fifty patients (42 male, 8 female) with suspected or proven HCC. The patients were subjected to a 3-Tesla-MRI-examination with Gd-EOB-DTPA and diffusion weighted imaging (DWI) at b-values of 0, 50 and 400 s/mm2. The apparent diffusion coefficient (ADC)-value was determined for each lesio
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RUSSO, MICAELA. "MULTIMODAL IMAGING IN ONCOLOGY RESEARCH: MRI AND BIOLUMINESCENCE STUDIES IN A MURINE MODEL OF PANCREATIC CANCER." Doctoral thesis, Università degli Studi di Milano, 2013. http://hdl.handle.net/2434/219127.

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Adenocarcinoma of the pancreas is one of the most aggressive human malignancies. Better models to study tumor behavior in vivo are needed for the development of more effective therapeutics. In the attempt to create clinically relevant models for studying novel treatments directed against pancreatic cancer, we defined a methodology to measure the effect of antineoplastic compounds in established human pancreatic cancer orthotopic xenografts using different luciferized pancreatic cancer cell lines (MiaPaCa-2 and Capan-1) to allow both magnetic resonance and bioluminescence imaging of animals in
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Terra, Guilherme Teixeira Coelho. "Aplicação das imagens de ressonância magnética convencionais e ponderadas por difusão no diagnóstico de alterações das glândulas salivares maiores." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/23/23139/tde-10062017-111546/.

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A ressonância magnética (RM) tem sido amplamente utilizada no diagnóstico por imagem de alterações de glândulas salivares. No entanto, a presença de aspectos similares nas imagens com técnicas convencionais de RM dificulta a distinção do diagnóstico entre patologias inflamatórias e neoplásicas. O objetivo deste estudo foi comparar valores dos coeficientes de difusão aparentes (ADC - Apparent Diffusion Coefficient) de imagem ponderada em difusão (DWI - Difusion Weighted Imaging) com ressonância magnética, entre glândulas salivares normais, casos com sialoadenite e com adenoma pleomórfico das gl
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Mirus, Matthew M., Sergey V. Tokalov, Gerald Wolf, Jerilyn Heinold, V. Prochnow, and Nasreddin Abolmaali. "Noninvasive assessment and quantification of tumour vascularisation using MRI and CT in a tumour model with modifiable angiogenesis – An animal experimental prospective cohort study." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2018. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-232305.

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Background To investigate vascular-related pathophysiological characteristics of two human lung cancers with modifiable vascularisation using MRI and CT. Methods Tumour xenografts with modifiable vascularisation were established in 71 rats (approval by the Animal Care Committee was obtained) by subcutaneous transplantation of two human non-small-cell lung cancer (NSCLC) cells (A549, H1299) either alone or co-transplanted with vascular growth promoters. The vascularity of the tumours was assessed noninvasively by MRI diffusion-weighted-imaging (DWI), T2-weighted, and time-of-flight (TOF) seque
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Boyer, Peter Gerard. "A Study of Bioluminescent and Magnetic Resonance Imaging in Murine Glioblastoma Models." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1408624457.

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37

Kurunlahti, M. (Mauno). "Association of impaired blood supply with painful lumbar disc degeneration." Doctoral thesis, University of Oulu, 2003. http://urn.fi/urn:isbn:9514270436.

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Abstract The purpose of this study was to evaluate the role of diminished arterial blood flow in painful disc degeneration. Diffusion in intervertebral discs of 37 asymptomatic adults measured by magnetic resonance imaging (MRI) and their lumbar arterial blood supply measured by magnetic resonance angiography (MRA) correlated significantly. End plate degeneration in intervertebral discs evaluated with MRI was analysed with reference to disc distress evaluated with computed tomography (CT) discography, and a significant correlation between end plate degeneration and disc degeneration was foun
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Teillac, Achille. "Tractographie globale sous contraintes anatomiques." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS357/document.

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Ce travail vise au développement d’une méthode d’inférence des fibres de la substance blanche cérébrale fondée sur l’utilisation d’une approche globale de type « verres de spins » sous contraintes anatomiques. Contrairement aux méthodes classiques reconstituant les fibres indépendamment les unes des autres, cette approche markovienne reconstruit l’ensemble des fibres dans un unique processus de minimisation d’une énergie globale dépendant de la configuration des spins (position, orientation, longueur et connexion(s)) et de leur adéquation avec le modèle local du processus de diffusion, afin d'
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Júnior, Antenor Tavares de Sá. "Alterações de difusão e perfusão cerebral por RM em angioplastia carotídea com \"stent\" sob proteção cerebral por filtros." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5151/tde-22022010-171639/.

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INTRODUÇÃO: A angioplastia carotídea com stent (ACS) sob proteção cerebral é opção terapêutica em pacientes com estenose carotídea. Existe o risco de embolia apesar da utilização do filtro e as modificações na perfusão cerebral após tratamento da estenose carotídea não são claras. O propósito deste estudo é avaliar, após ACS sob proteção cerebral por filtros, modificações nas seqüências de RM de difusão (DWI) e perfusão (PWI), correlacionando-as com os aspectos técnicos da ACS, com as características da estenose e com dados demográficos dos pacientes. MÉTODO: Trinta e seis pacientes portadores
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Ghayoor, Ali. "Improved interpretation of brain anatomical structures in magnetic resonance imaging using information from multiple image modalities." Diss., University of Iowa, 2017. https://ir.uiowa.edu/etd/5477.

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This work explores if combining information from multiple Magnetic Resonance Imaging (MRI) modalities provides improved interpretation of brain biological architecture as each MR modality can reveal different characteristics of underlying anatomical structures. Structural MRI provides a means for high-resolution quantitative study of brain morphometry. Diffusion-weighted MR imaging (DWI) allows for low-resolution modeling of diffusivity properties of water molecules. Structural and diffusion-weighted MRI modalities are commonly used for monitoring the biological architecture of the brain in no
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Hottier, Mouton Laura. "Développement de l’imagerie IRM de diffusion pour la caractérisation des atteintes neuropathologiques induites par les radiations ionisantes chez un modèle murin." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASS062.

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Le diagnostic ou le traitement d’une pathologie par l’emploi de rayonnements ionisants peut causer l’apparition de conséquences néfastes et irréversibles pour le cerveau notamment au cours de son développement. D’autant plus, si on considère certains facteurs génétiques modulant la radiosensibilité des individus exposés. Il devient alors nécessaire de développer des marqueurs d’imagerie sensibles aux atteintes cérébrales de l’irradiation à la fois aux fortes et aux faibles doses. Cette thèse a permis de développer une approche non-invasive, par IRM anatomique et de diffusion, p
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Pontabry, Julien. "Construction d'atlas en IRM de diffusion : application à l'étude de la maturation cérébrale." Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAD039/document.

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L’IRM de diffusion (IRMd) est une modalité d’imagerie médicale in vivo qui suscite un intérêt croissant dans la communauté de neuro-imagerie. L’information sur l’intra-structure des tissus cérébraux est apportée en complément des informations de structure issues de l’IRM structurelle (IRMs). Ces modalités d’imagerie ouvrent ainsi une nouvelle voie pour l’analyse de population et notamment pour l’étude de la maturation cérébrale humaine normale in utero. La modélisation et la caractérisation des changements rapides intervenant au cours de la maturation cérébrale est un défi actuel. Dans ce but,
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Alison, Marianne. "Imagerie fonctionnelle du placenta en IRM." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA112329.

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L’insuffisance placentaire par défaut de vascularisation est une pathologie fréquente de la grossesse, de diagnostic difficile, avec des complications potentiellement graves (retard de croissance intra utérin, prééclampsie). L’objectif de ce travail de Thèse a été de développer l’IRM fonctionnelle multiparamétrique pour l’exploration du placenta à 4.7 T chez la rate gestante. Matériel et méthode : L’IRM de diffusion (SE- EPI DWI) avec analyse IVIM et l’IRM dynamique avec injection de gadolinium (DCE) et haute résolution temporelle (&lt; 1s) ont été développées puis étudiées sur un modèle murin
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Cano, Manuel Nicolas. "Estudo randomizado comparando dois dispositivos de proteção cerebral no implante de stent carotídeo: avaliação de novos focos isquêmicos através das sequências de difusão por ressonância magnética." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/98/98131/tde-07122012-110520/.

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Introdução: O Stent Carotídeo (SC) surgiu como uma alternativa à cirurgia de endarterectomia para o tratamento de estenose carotídea extracraniana com o objetivo de prevenir o acidente vascular encefálico (AVE). O sucesso do SC depende de estratégias que minimizem o risco de AVE. No início do estudo não existiam estudos randomizados comparando o implante de stent carotídeo com diferentes tipos de proteção cerebral. Objetivos: Testar de forma aleatória a eficácia de dois diferentes princípios de proteção embólica no território carotídeo (Angioguard®) e Mo.Ma), utilizando a ressonância magnética
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Pron, Alexandre. "Etude de la connectivité structurelle des faisceaux d'association courts de la substance blanche du cerveau humain en IRM de diffusion." Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0391.

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Les fibres d’association courtes (fibres en U) de la substance blanche connectent des territoires corticaux situés dans des gyri adjacents. L’estimation in vivo de l’extension spatiale de ces fibres requiert des données IRM pondérées en diffusion (IRMd) à résolution spatiale et angulaire élevée afin de limiter l’effet du volume partiel à l’interface cortex/substance blanche et de capturer la complexité des configurations de fibres de la matière blanche superficielle. De telles données nécessitent des méthodes de prétraitement adaptées. De plus, l’étude quantitative de la connectivité de ces fi
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Lin, Chieh. "Imagerie fonctionelle corps entier dans les hémopathies lymphoïdes." Thesis, Paris Est, 2009. http://www.theses.fr/2009PEST0053.

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Trois aspects principaux de l'imagerie fonctionnelle corps entier dans les hémopathies lymphoïdes ont été étudiés dans ma thèse. Nous avons d'abord démontré en étudiant 92 patients avec un lymphome B à grandes cellules que 14 patients (15%) considérés positifs sur l'analyse visuelle du FDG-TEP après deux cycles de chimiothérapie, auraient pu être reclassés comme des bons répondeurs si le pourcentage de réduction du SUVmax avait été mesuré. Dans un sous groupe de 80 patients, une deuxième étude a permis de montrer qu'après 4 cycles, l'analyse visuelle et l'analyse semi-quantitative SUV étaient
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Ruoss, Kerstin Andrea. "1. Brain development (sulci and gyri) as assessed by MR imaging in preterm and term newborn infants. 2. Germinal matrix hemorrhage and white matter lesions in neonates; correlation of serial ultrasound and early magnetic resonance imaging findings. 3. Diffusion-weighted MRI of middle cerebral artery stroke in a newborn /." Bern, 2002. http://www.stub.unibe.ch/html/haupt/datenbanken/diss/bestell.html.

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48

Genovese, Guglielmo. "Evaluation of microstructural alterations in the human brain and in experimental models with diffusion-weighted magnetic resonance spectroscopy." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS545.

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La spectroscopie pondérée en diffusion (DW-MRS) est un outil unique pour étudier la microstructure cérébrale, grâce à la compartimentation spécifique des métabolites dans les différents types de cellules cérébrales. Dans cette thèse, on a étudié la DW-MRS de plusieurs manières complémentaires afin de pouvoir appliquer cette technique à des études cliniques: optimisation du pipeline d’acquisition et de l’analyse des données, reproductibilité des mesures de diffusion et validation histologique des métriques de DW-MRS comme marqueurs potentiellement utiles des altérations de la microstructure lié
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Sveder, Anna, and Martin Lindberg. "Användbarheten av diffusionsviktade sekvenser vid MRT för att påvisa uteruscancer En litteraturstudie." Thesis, Luleå tekniska universitet, Institutionen för hälsovetenskap, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-67298.

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Inledning: Uteruscancer är den sjätte vanligaste cancerformen hos kvinnor i världen. Ny forskning pekar på att diffusionsviktad magnetresonanstomografi (MRT) kan vara en tillförlitlig undersökningsmetod för att detektera patologiska förändringar i uterus. Syfte: Att skapa en översikt av användbarheten av diffusionsviktade sekvenser vid MRT för att påvisa uteruscancer. Metod: Allmän litteraturöversikt, tio kvantitativa studier inkluderades. Resultat: Diffusionsviktade sekvenser vid MRT har högre sensitivitet, specificitet samt diagnostisk noggrannhet för att påvisa patologiska
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Chou, Chen-Pin, and 周春平. "Application of Diffusion-weighted MRI for Pelvic Abscess." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/73915290938348457505.

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碩士<br>國立陽明大學<br>臨床醫學研究所<br>98<br>The purpose of this study was to demonstrate the clinical applications of diffusion-weighted MRI techniques for patients with pelvic abscesses. Eleven patients (age 37-78 years, average 42 years) with a final diagnosis of pelvic abscess in Kaohsiung Veterans General Hospital underwent pelvic MRI examinations, which included diffusion-weighted sequences at the two different b values (b=0 and1000 s/mm2) in addition to conventional MRI sequences. Pelvic abscesses were confirmed in all patients by surgery or needle aspiration. In six patients, pathogens, including
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