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Dissertations / Theses on the topic 'Digestive cancers'

Author: Grafiati
Published: 11 January 2025
Last updated: 31 July 2025

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1

Le, Scanf Enora. "Caractérisation des altérations de l’épissage des ARN pré-messagers dans les cancers digestifs à microsatellites instables." Electronic Thesis or Diss., Brest, 2024. http://www.theses.fr/2024BRES0113.

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L’exon en aval dans l’ARNm, dépendant du gène considéré et de la taille de la délétion dans le SP-MS. Nous montrons qu’un SP-MS raccourci présente moins d’affinité pour la protéine U2AF2 in vitro et que la mutation U2AF1-S34F ou le knock-down d’U2AF1 peuvent mimer l’effet de l’altération du PyT. Enfin, les transcrits matures dépourvus de l'exon cible peuvent être soit stables, soit dégradés par le système NMD de surveillance des codons non-sens prématurés, et ne sont donc pas dotés d'une capacité spécifique à éviter la dégradation. Nous supposons que les protéines aberrantes, qui peuvent être
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2

Macaire, Pauline. "Modélisation par une approche de population de l’effet des facteurs de croissance granulocytaire lors de neutropénies chimio-induites." Thesis, Bourgogne Franche-Comté, 2020. http://www.theses.fr/2020UBFCJ001.

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Les travaux de cette thèse s'appuient sur les résultats d'une étude de cohorte ayant pour objectif principal de définir le schéma optimal d'administration prophylactique des facteurs de croissance granulocytaire (G-CSF) dans le cadre d’un traitement par FOLFIRINOX. Pour ce faire, un modèle pharmacocinétique/pharmacodynamique (PK/PD) a été construit pour décrire l'évolution des polynucléaires neutrophiles (PNN) en fonction du temps dans notre population en tenant compte de l'effet neutropéniant des trois chimiothérapies administrées mais également de l'effet stimulant des G-CSF exogènes sur la
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3

Väkeväinen, Satu. "Local acetaldehyde production as a pathogenetic factor for upper digestive tract cancers in humans." Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/vakevainen/.

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4

Vila, Casadesús Maria. "Design of bioinformatic tools for integrative analysis of microRNA-mRNA interactome applied to digestive cancers." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/663087.

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En esta tesis se han desarrollado e implementado distintas herramientas bioinformáticas que permiten el estudio de las interacciones miRNA-mRNA en contextos celulares específicos. oncretamente se ha creado un paquete de R (miRComb) que calcula las interacciones miRNA-mRNA partiendo de expresión de miRNAs y mRNAs, y predicciones bloinformáticas de bases de datos preexistentes. Las interacciones miRNA-mRNA finales son aquellas que muestran una correlación negativa y han estado predichas por al meno una base de datos. Como valor añadido, el paquete miRComb realiza un resumen en pdf con los result
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5

Perrichet-Pechinez, Anaïs. "Ciblage de l'IL-1beta pour améliorer l'efficacité de la chimio-immunothérapie dans le cancer." Electronic Thesis or Diss., Bourgogne Franche-Comté, 2024. http://www.theses.fr/2024UBFCI014.

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L'IL-1b est connue pour avoir un rôle ambivalent dans le microenvironnement tumoral. Le cancer du poumon et le cancer colorectal figurent parmi les cancers les plus meurtriers, et l'incidence de l'adénocarcinome canalaire pancréatique a considérablement augmenté au cours des 30 dernières années. Ce projet vise à étudier le rôle de l'IL-1b dans les cancers du poumon, du côlon et du pancréas en condition de traitement par chimio-immunothérapie et démontrer comment cette interleukine agit dans le microenvironnement tumoral afin d’identifier des pistes d’amélioration thérapeutique.Dans le cancer d
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6

Cui, Yan. "Polymorphism of xeroderma pigmentosum group G and dietary flavonoid intake on the risk of lung and upper aero-digestive tract cancers." Diss., Restricted to subscribing institutions, 2005. http://proquest.umi.com/pqdweb?did=954047411&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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7

Gupta, Bhawna. "Life-course approach to behavioural risk factors and quality of life for cancers of the upper aero-digestive tract in an Indian population: a case-control study." Thesis, Griffith University, 2018. http://hdl.handle.net/10072/371971.

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The incidence and mortality rates of cancers of upper aero-digestive tract (UADT) remain significantly high in India. These cancers, which occur more commonly in later adulthood, are influenced by social and lifestyle behaviours carried out during childhood, adolescence and early adult life. Thus, life-course epidemiology attempts to assess varying health effects of various risk factors, according to timing, duration and frequency of exposure, which may give important clues to the causes of cancer. These cancers have serious impacts on quality of life (QoL) as they involve anatomical structure
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8

Chen, Jun 1969. "The association between dietary intake and the risk of cancers of the upper aero-digestive tract : a case-control study in Brazil." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=29422.

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Cancers of the upper aero-digestive tract (UADT) rank as the fifth most common neoplastic disease worldwide. Two identified risk contributors are consumption of tobacco and alcohol. Among all other potential etiological factors, diet has long been recognized to play an important role in the development of cancers of the UADT. Data from a multi-centre, hospital-based case-control study conducted in Brazil were used to assess the association of dietary intake with the risk of cancers of the UADT. Dietary assessment was made in terms of estimated intake of nutrients, specific foods and food group
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9

He, Hua, and 何華. "Anti-tumor mechanisms of cyclooxygenase inhibitors and a c-Jun-N-terminal kinase inhibitor in gastrointestinal cancers." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B30075245.

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10

Collard, Olivier Conroy Philippe. "Chirurgie des métastases hépatiques dans les cancers colo-rectaux étude rétrospective de 84 patients opérés au Centre Alexis Vautrin et en chirurgie digestive générale, CHU de Nancy de 1985 à 2000 /." [S.l.] : [s.n.], 2002. http://www.scd.uhp-nancy.fr/docnum/SCDMED_T_2002_COLLARD_OLIVIER.pdf.

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11

Moura, Kelly Cristina Rodrigues de [UNESP]. "Análise da frequencia do polimorfismo rs12979860 C/T no gene IL28B em pacientes acometidos por câncer gástrico." Universidade Estadual Paulista (UNESP), 2015. http://hdl.handle.net/11449/126466.

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Made available in DSpace on 2015-08-20T17:09:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-02-26. Added 1 bitstream(s) on 2015-08-20T17:26:18Z : No. of bitstreams: 1 000839769.pdf: 1095151 bytes, checksum: 5c5372db38bb52b66a5da5b0b13785b5 (MD5)<br>O câncer gástrico é um dos tipos de câncer mais comum e está associado com uma alta frequência de mortalidade. Embora nas últimas décadas tenha ocorrido um decréscimo na incidência mundial, o prognóstico desta patologia permanece ruim, principalmente quando o diagnóstico é feito em estágios avançados. A etiologia é complexa e multifator
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12

Moura, Kelly Cristina Rodrigues de. "Análise da frequencia do polimorfismo rs12979860 C/T no gene IL28B em pacientes acometidos por câncer gástrico /." Botucatu, 2015. http://hdl.handle.net/11449/126466.

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Orientador: Adriana Camargo Ferrasi<br>Banca: Maria Inês de Campos Moura Pardini<br>Banca: Juliana Garcia de Oliveira<br>Resumo: O câncer gástrico é um dos tipos de câncer mais comum e está associado com uma alta frequência de mortalidade. Embora nas últimas décadas tenha ocorrido um decréscimo na incidência mundial, o prognóstico desta patologia permanece ruim, principalmente quando o diagnóstico é feito em estágios avançados. A etiologia é complexa e multifatorial, onde a combinação de fatores genéticos e ambientais parecem estar envolvidos na carcinogênese e progressão da doença. Desta form
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13

De, Rosa Antonella. "Oestrogen receptors in oesophageal cancer." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/52399/.

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Introduction: Oesophageal cancer is more common in men than women. Oestrogen, which mediates its effects via oestrogen receptors (ERs), may be responsible for the gender disparity. This thesis investigates the role of ERs in oesophageal cancer development and explores potential therapeutic possibilities. Methods: ERα and ERβ expression in oesophageal AC cell lines (OE19 and OE33) was knocked down using siRNA, and the effect of knockdown on the expression of proliferation-associated proteins (Ki67, PCNA, E-cadherin, Cyclin D) was assessed. The effect of the SERM, tamoxifen, on oesophageal cance
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14

Khreiche, Antoine. "Aspects héréditaires des cancers digestifs familiaux." Montpellier 1, 1998. http://www.theses.fr/1998MON11050.

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15

Mirams, Gary R. "Subcellular phenomena in colorectal cancer." Thesis, University of Nottingham, 2008. http://eprints.nottingham.ac.uk/10567/.

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The Wnt signalling pathway is involved in stem cell maintenance, differentiation and tissue development, and in so doing plays a key role in controlling the homeostasis of colorectal crypts. In response to an external Wnt stimulus, the intracellular levels of the protein beta-catenin are regulated by the proteins which make up the Wnt signalling pathway. Abnormalities in the Wnt signalling pathway have been implicated in the initiation of colorectal and other cancers. In this thesis we analyse and simplify existing models of the Wnt signalling pathway, formulate models for Wnt's control of the
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16

Saunders, John. "Ex vivo modelling of oesophago-gastric cancer." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/47574/.

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Introduction The response to neoadjuvant chemotherapy in oesophago-gastric (OG) cancer is only 40%, so over half of the patient’s disease will progress, whilst they also suffer the toxic chemotherapy side-effects. A model to predict chemotherapy response would provide a marked clinical benefit, by enabling personalised treatment of OG cancer. Methods Live chemo-naïve tumour biopsies were obtained following informed consent at staging endoscopy, before patients underwent their routine neoadjuvant chemotherapy. Tumour cells from the endoscopic biopsies were expanded, using an in vitro feeder la
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17

Lafon, Cyril. "Développement d'un applicateur interstitiel ultrasonore pour l'endoscopie digestive." Lyon 1, 1999. http://u556.lyon.inserm.fr/theses/pdf/lafon.pdf.

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18

JEUNET, ERIC. "Hepatectomies iteratives pour metastases de cancers digestifs." Lyon 1, 1990. http://www.theses.fr/1990LYO1M394.

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19

Akhlaq, Maham. "Investigation of Cten signalling and regulation in colorectal cancer." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/32802/.

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Cten (also known as Tensin4) is the fourth member of the Tensin gene family. It lacks the N terminal actin binding domain while retaining the C terminal SH2 and PTB domains. This helps to bind Cten to the intracytoplasmic tail of β1 integrin and puts it at the heart of focal adhesions. It is reported to be a tumour suppressor in kidney and prostate cancer where normal tissues show high expression. However in a number of tumours, including colorectal cancer, Cten has been labelled as an oncogene. Cten which normally is a cytoplasmic protein gives nuclear staining in colorectal metastatic deposi
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20

Alsulaiman, Abdullah. "Investigation of the role of CD24 in metastatic colorectal cancer." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/55401/.

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CD24 is a small (81 amino acids) GPI anchored protein which is involved in promoting cell motility and stemness and may be a part of the metastatic process. It is a heavily glycosylated molecule and contains numerous O-glycosylation sites together with two N-glycosylation sites. N-glycosylation is thought to be important in protein function, and therefore, the aim of this study is to (a) investigate the importance of N-glycosylation in the function of CD24, (b) identify other potentially functional sites in CD24 by deletion mapping, (c) define downstream targets of CD24, and (d) identify the e
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21

Asiri, Abdulaziz. "Investigations into the role of Cten signalling in colorectal cancer." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/52233/.

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C-terminal tensin-like (Cten, also known as Tensin4) is the member of the tensin gene family. Cten functions as an oncogene in a variety of cancer types and its expression is commonly associated with poor prognosis and metastasis in colorectal cancer (CRC). Although several studies have shown that Cten has a critical role in the regulation of cell motility and invasion in different tumour tissues, the underlying signalling mechanisms have not been fully elucidated. This thesis investigated the biological activity of Cten in four different ways in order to further elucidate the mechanisms of Ct
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22

Royal, E. L. "Interplay between hypoxia and gastrin in gastrointestinal cancer." Thesis, University of Nottingham, 2009. http://eprints.nottingham.ac.uk/10805/.

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Tumour hypoxia has been linked to increased resistance to both radiotherapy and chemotherapy, especially in solid metastatic GI tumours. Under hypoxic conditions, genes that promote tumour growth and survival are up-regulated, via the transcription factor hypoxia-inducible factor-1 (HIF-1). The digestive hormone gastrin, which is often over-expressed in GI cancers, has also been shown to act as a pro-survival factor, up-regulating processes such as tumour proliferation, angiogenesis and migration, and down-regulating apoptosis. Due to the high level of similarity between the downstream events
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23

Onyido, Emenike K. "Mechanisms and roles of FLYWCH1 in colorectal cancer." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/42558/.

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Human colorectal cancer (CRC) is the fourth most common cause of cancer-related death in the UK and worldwide. Defects in conserved signalling pathways play key roles in the development of almost all cancers and, in CRCs, over 80% of tumours show hyper-activation of the canonical Wnt signalling pathway. This pathway, through the transcriptional activity of β-catenin (and its binding partner, TCF4), maintains the stem cell compartment of colon and intestinal-crypts as well as cancer-initiating cells. Whilst the role of β-catenin/TCF4 in the development of both normal and neoplastic colon/intest
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24

Lefaure, Jean-Marc. "Intérêt de l'antigène carcinoembryonnaire, ACE, en cancérologie digestive." Paris 5, 1991. http://www.theses.fr/1991PA05P003.

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25

GASPAR, LODS MANUELA. "Cancer des voies aero-digestives superieures et douleur." Besançon, 1994. http://www.theses.fr/1994BESA3030.

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26

Ham, Karom Hersh Abdul. "Investigate tumour heterogeneity and genetic pathways in colorectal cancer." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/42487/.

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Background: Colorectal cancer is a major global public health problem that has predominantly been considered a genetic disease following a precise series of molecular events. These are characterized by sequential accumulation of genetic and epigenetic alteration in several oncogenes and tumour suppressor genes. Understanding of the genetic mechanisms that explain the initiation and evolution of colorectal cancer are key to improving risk prediction, prognostication and treatment. Aims: The aim of this study was to understand the basic principles of the molecular biology of colorectal cancer ba
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27

Al-Masmoum, Hussain. "An investigation of chromosome 20q13 amplification in colorectal cancer." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/36938/.

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Background: Colorectal cancer (CRC) is the third most prevalent and second most fatal type of cancer in the Western world. 20q amplification has been identified in approximately 50% of CRC cases. 20q amplification and may be associated with liver metastasis. In our lab, a previous array comparative genomic hybridization (aCGH) study of a series of primary CRCs and corresponding liver metastases, found that the 20q13 was frequently amplified in both groups. Several known oncogenes are located at Chromosome 20q (for example SRC, TPX2 and CSE1L) suggesting that 20q amplification may be an importa
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Drugeon, Dutin Cécile. "Pratiques en cancérologie digestive : enquête prospective auprès des gastroentérologues du Sud-Ouest." Bordeaux 2, 1997. http://www.theses.fr/1997BOR2M149.

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29

Barabino, Gabriele. "La chirurgie digestive oncologique aidée par la fluorescence." Thesis, Saint-Etienne, 2015. http://www.theses.fr/2015STET006T/document.

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Dans notre travail de thèse, nous nous sommes attachés à répondre à cette question : peut-t-on améliorer la résécabilité tumorale dans le métastases hépatiques et péritonéales du cancer colorectal? Pour cela nous nous sommes appuyés sur deux éléments : la fluorescence du vert d’indocyanine et sa détection par la caméra NIR. Dans un premier temps, après une mise au point en laboratoire, nous avons appliqué cette technique aux résections hépatiques. Nous avons montré que cette technique a un double intérêt : la détection des lésions tumorales et l’amélioration de la marge de résection oncologiqu
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Gamelin, Erick. "Pharmacologie clinique du 5-fluorouracile et de certains sels de platine chez des patients souffrant de cancers du tractus digestif et des voies aéro-digestives supérieures." Bordeaux 2, 1997. http://www.theses.fr/1997BOR28484.

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31

Gemmill, Elizabeth H. "Minimally invasive gastro-oesophageal surgery for cancer : current evidence and practice." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/55424/.

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Background Since its introduction in the early 1990s, minimally invasive gastro-oesophageal surgery for cancer has been growing in popularity. Despite this, published evidence on this type of technique is weak and its role in the management of gastric and oesophageal cancer remains controversial. Aims The aim of this thesis was to test the hypothesis that: minimally invasive gastro- oesophageal cancer surgery has superior outcomes compared to control studies of conventional open surgery; but current studies are methodologically inadequate to confirm this. Methods The first study (chapter 3) is
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32

LANGRAND-ESCURE, PHILIPPE. "Role de l'exerese digestive dans la chirurgie du cancer de l'ovaire." Clermont-Ferrand 1, 1989. http://www.theses.fr/1989CLF13077.

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33

Lasolle, Christophe. "Métastases digestives des cancers bronchiques : à propos de deux cas cliniques." Nancy 1, 1992. http://www.theses.fr/1992NAN1A002.

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34

Boereboom, Catherine L. "Determining the feasibility and effectiveness of high intensity interval training in preoperative colorectal cancer patients." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/47342/.

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Colorectal cancer (CRCa) is the 4th most common cancer in the United Kingdom with 41,265 new cases diagnosed in 2014 (Cancer Research UK, 2017). Advancing age is an established risk factor for the development of CRCa (Figure 1.1); between 2012 and 2014 44% of new cancers were diagnosed in patients aged 75 years and over (Cancer Research UK, 2017). Due to our ageing population, national screening programmes and improved diagnostic techniques, a greater number of older people are now being diagnosed with CRCa. However older people are not surviving the disease as well as their younger counterpar
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Tognarelli, Bruno. "Bilan d'extension des cancers digestifs : laparoscopie ou imagerie médicale ?" Montpellier 1, 1992. http://www.theses.fr/1992MON11156.

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36

Benhamiche, Anne-Marie. "Épidémiologie descriptive des cancers digestifs : incidence, prévalence, tendances chronologiques." Dijon, 2000. http://www.theses.fr/2000DIJOMU05.

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Par leur fréquence et leur gravité, les cancers digestifs posent un réel problème de santé publique. Le Registre Bourguignon des Cancers Digestifs a été crée avec l'idée que la recherche épidémiologique et la recherche en santé publique permettent de concevoir de nouvelles modalités de lutte contre ces cancers. Dans ce contexte, l'objectif de ce travail est de souligner l'intérêt de l'épidémiologie descriptive. Les données collectées localement et dans le cadre du réseau FRANCIM ont modifié nos connaissances sur la fréquence des cancers digestifs qui reposaient auparavant sur les statistiques
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Lepage, Côme. "Epidémiologie des cancers digestifs rares : incidence, tendances chronologiques, pronostic." Dijon, 2007. http://www.theses.fr/2007DIJOMU01.

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L’objectif principal de ce travail était d’améliorer les connaissances épidémiologiques des tumeurs digestives rares jusqu’alors parcellaires puisque essentiellement basées sur des données hospitalières. Nous avons pu montrer qu’à l’image des autres cancers digestifs, leur incidence est en constante augmentation, et concernant adénocarcinomes de l’oesophage que cette hausse était en passe de devenir préoccupante. Ce travail réunit des données épidémiologiques sur les cancers digestifs rares à partir de bases de population qui pour la plupart étaient inexistantes. Ces données sont précieuses po
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Grellet, Pierre. "Les tumeurs du tube digestif dans les Pyrénées Orientales : étude statistique de 1984 à 1990." Montpellier 1, 1992. http://www.theses.fr/1992MON11038.

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Méthy, Nicolas. "Identification et évaluation des critères de substitution en cancérologie digestive." Dijon, 2009. http://www.theses.fr/2009DIJOMU04.

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En cancérologie, le critère de jugement de référence dans les essais cliniques de phase III est la survie globale. Une longue période de suivi est parfois nécessaire à son évaluation. Le recours à un critère de substitution permet alors de réduire la durée des essais. Un critère de substitution doit permettre de prédire l'effet du traitement expérimental sur le critère clinique de référence. Deux approches statistiques sont proposées pour s'assurer de cette relation. La première consiste à estimer la proportion de l'effet traitement expliquée par le critère de substitution. La seconde, dite mé
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Faivre-Finn, Corinne. "Amélioration des pratiques de soin et du pronostic du cancer colo-rectal : études de population." Dijon, 2001. http://www.theses.fr/2001DIJOMU10.

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LA PRISE EN CHARGE DU CANCER COLO-RECTAL A BEAUCOUP EVOLUE AU COURS DES 25 DERNIERES ANNEES. TRES PEU DE DONNEES SONT DISPONIBLES CONCERNANT LES AMELIORATIONS THERAPEUTIQUES, L'IMPACT DES ESSAIS THERAPEUTIQUES SUR LES PRATIQUES DE SOIN ET L'EVOLUTION DU PRONOSTIC DE CETTE MALADIE A L'ECHELLE D'UNE POPULATION. CE TRAVAIL EST BASE SUR LES REGISTRES DES TUMEURS DIGESTIVES DE LA COTE-D'OR, DE LA SAONE ET LOIRE ET DU CALVADOS. LE TAUX D'EXERESE EST PASSE DE 66. O % A 80. 1 % ENTRE 1978 A 1993 POUR LE CANCER DU RECTUM ET DE 69. 3 % A 91. 9 % ENTRE 1976 ET 1991 (TAUX STABLE APRES 1991) POUR LE CANCER
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Constant, Emilie. "Approche multidimensionnelle de l’intimité conjugale et de ses déterminants socio-cognitifs et émotionnels : du couple tout-venant au couple confronté au cancer digestif." Thesis, Lille 3, 2016. http://www.theses.fr/2016LIL30028.

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Un sentiment global d’intimité se construit à travers des composantes comportementales ainsi que, des expériences d’intimité qui correspondent à la perception de la réactivité du partenaire. De plus, la manière dont les individus appréhendent leurs relations interpersonnelles ainsi que leurs émotions et celles d’autrui, est susceptible d’influencer la construction de cette intimité. La qualité de l’intimité conjugale se caractériserait par trois dimensions : (1) un sentiment de connexion, (2) une bonne communication et (3) un partage de loisirs avec des amis communs (Article 1). En outre, la c
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Murphy, Jamie. "The role of PROM-1/CD/AC133 in colorectal cancer." Thesis, Queen Mary, University of London, 2012. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8838.

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Background: Colorectal cancer is the result of dysregulation within classic regulatory pathways in epithelial stem-cell(s): the precursors giving rise to all other intestinal lineages. The resulting cancer stem-cell (CSC) generates tumours utilising its innate properties, e.g. self-renewal and lineage plasticity. CSCs appear to persist within a tumour as a distinct subtype responsible for local recurrence/metastasis. Therefore, therapies targeting colorectal CSCs may lead to improved cancer-specific outcome measures. The PROM-1/CD/AC133 cell surface marker has been associated with colorectal C
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Moka, Nagaishwarya, Manisha Nukavarapu, Jennifer Phemister, and Mckinney Jason. "Small cell lung cancer(SCLC) disguised as Dysphagia." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/asrf/2019/schedule/168.

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Common presenting symptoms of Lung cancer are cough, hemoptysis, chest pain, dyspnea, pleurisy. Dysphagia is a very uncommon presenting feature of Lung cancer. Incidence of Dysphagia in Lung cancer is unclear from Literature. Causes of Dysphagia in case of Lung cancer are Anatomically classified as Oropharyngeal and Esophageal. Causes of oropharyngeal dysphagia are oral candidiasis, oropharyngeal Metastasis of Lung cancer. Causes of esophageal dysphagia are Cervical or Mediastinal Lymphadenopathy, Motor dysfunction because of Brain stem Metastasis, Lambert eaton syndrome, Esophageal candidiasi
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Albasri, Abdulkader. "An investigation of the role of C-terminal tensin-like (Cten) gene in colorectal cancer." Thesis, University of Nottingham, 2011. http://eprints.nottingham.ac.uk/12055/.

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The C-terminal tensin-like (Cten) gene is a member of the tensin family and is localised at the cytoplasmic tail of β-integrin. It is involved in various biological events although the role of in the development of colorectal cancer (CRC) is uncertain. In order to study this, the expression of Cten during the development of CRC was initially evaluated using immunohistochemistry (IHC) on colorectal adenomas and carcinomas. Positive immunoreactivity for Cten was observed in 317/342 (92.6%) of CRC and 19/20 (90%) of colorectal adenoma. High Cten expression was significantly associated with advanc
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45

Findlay, John Mitchell. "Precision staging and management of Barrett's oesophagus and oesophageal cancer : genomic, imaging and pathological biomarkers." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/38037/.

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Barrett’s oesophagus and oesophageal cancer represent two of the most important and challenging oesophageal disease processes globally, combining increasing incidences with high morbidity treatments, often with poor clinical outcomes. A major contributory factor is that disease susceptibility, progression and response to therapy are largely unpredictable, due to inherent biological complexity and variability. At present, just staging groups are used routinely as thresholds for guiding the use of therapies such as ablation, resection, and oncological therapies. However, these represent blunt to
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46

TOUILLON, ANVARI NASSIME. "Incidence des cancers digestifs en saone-et-loire (1982-1992)." Dijon, 1994. http://www.theses.fr/1994DIJOM108.

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47

Ducreux, Michel. "Tumeurs neuroendocrines : nouvelles approches diagnostiques et thérapeutiques, facteurs pronostiques." Dijon, 2000. http://www.theses.fr/2000DIJOMU16.

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Les tumeurs neuroendocrines (tne) sont des tumeurs rares dont le point de depart est le plus souvent digestif. Les objectifs de ce travail ont ete de definir la place des nouveaux examens, l'efficacite des nouvelles therapeutiques permettant d'ameliorer la strategie diagnostique et therapeutique de ces tumeurs. Apres une premiere etude demontrant le peu d'interet de la recherche de catecholamines urinaires, une seconde etude a montre que la chromogranine a etait plus sensible et avait une meilleure valeur predictive positive que l'enolase neurone-specifique. Enfin une grande etude de screening
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48

VOLPATTO, SILVIO. "Robotic technology and endoluminal surgery in digestive surgery." Doctoral thesis, Politecnico di Torino, 2018. http://hdl.handle.net/11583/2709912.

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BACKGROUND. Colorectal cancer (CRC) is the third most common cancer in males and second in females, and the fourth most common cause of cancer death worldwide. The implementation of screening programs has allowed to the identification of an increasing number of early-stage neoplastic lesions. Presently, superficial colorectal neoplasms (including precancerous lesions and early cancer) can be resected in the colon by Endoscopic Mucosal Resection (EMR) and Endoscopic Submucosal Dissection (ESD), while in the rectum by Transanal Endoscopic Microsurgery (TEM). They are the preferred choices inside
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Maxwell-Armstrong, Charles Alan. "Studies using the anti-idiotypic monoclonal antibody 105AD7 in patients with advanced and primary colorectal cancer." Thesis, University of Nottingham, 1998. http://eprints.nottingham.ac.uk/14137/.

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Introduction. The anti-idiotypic monoclonal antibody 10SAD7 mimics the tumour associated antigen 791T/ gp72, present on approximately 80% of colorectal cancer cells. A Phase I study using 10SAD7 in 13 patients with advanced colorectal cancer has shown that it is nontoxic, and conferred a survival advantage on patients who received it [Denton GWL 1994]. Aim. There were two aims of this work. The first was to assess whether. the survival advantage seen in the Phase I study was reproducible in a Phase II study. The second was to immunise patients with primary colorectal cancer, in a non-randomise
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50

Segara, Davendra St Vincents Hospital Clinical School UNSW. "Studies of retinoic acid signalling in pancreatic cancer." Awarded by:University of New South Wales. St Vincents Hospital Clinical School, 2006. http://handle.unsw.edu.au/1959.4/26269.

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Pancreatic cancer (PC) is the fourth leading cause of cancer death in Western societies. Despite significant progress in understanding the molecular pathology of PC and its precursor lesion: pancreatic intraepithelial neoplasia (PanIN), there remain no molecules with proven clinical utility. Affymetrix Genechipfi oligonucleotide microarrays were used to interrogate mRNA expression of PC and normal pancreas to identify molecular pathways dysregulated in PC. Analysis of these data identified altered expression of numerous components of the S100 Calcium Binding Protein Family, Retinoic Acid signa
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