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Journal articles on the topic 'Digital Therapeutics'

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1

Yoo, Joo Hun, Harim Jeong, and Tai-Myoung Chung. "Cutting-Edge Technologies for Digital Therapeutics: A Review and Architecture Proposals for Future Directions." Applied Sciences 13, no. 12 (2023): 6929. http://dx.doi.org/10.3390/app13126929.

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Digital therapeutics, evidence-based treatments delivered through software programs, are revolutionizing healthcare by utilizing cutting-edge computing technologies. Unlike conventional medical treatment methods, digital therapeutics are based on multiple information technologies, from data collection to analysis algorithms, and treatment support approaches. In this research, we provide a comprehensive overview of the latest technologies involved in the development of digital therapeutics and highlight specific technologies necessary for the future growth of the rapidly evolving digital therap
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Hong, Ji Sun, Chris Wasden, and Doug Hyun Han. "Introduction of digital therapeutics." Computer Methods and Programs in Biomedicine 209 (September 2021): 106319. http://dx.doi.org/10.1016/j.cmpb.2021.106319.

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Thorndike, Frances P. "Prescription Digital Therapeutics: Evidence." Health Affairs 43, no. 6 (2024): 897. http://dx.doi.org/10.1377/hlthaff.2024.00068.

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Bashan, Eran. "Prescription Digital Therapeutics: Devices." Health Affairs 43, no. 6 (2024): 896. http://dx.doi.org/10.1377/hlthaff.2024.00159.

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Molnar, Andrew. "Prescription Digital Therapeutics: Assertions." Health Affairs 43, no. 6 (2024): 897. http://dx.doi.org/10.1377/hlthaff.2024.00152.

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Sverdlov, Alex. "Introduction to digital therapeutics." Biomedical & Life Sciences Collection 2025, no. 1 (2025): e1006561. https://doi.org/10.69645/jfbb2228.

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Shah, Amit, and Sachi Shah. "Chronopharmacology: Optimizing drug therapy through biological rhythms." National Journal of Physiology, Pharmacy and Pharmacology 14, no. 9 (2024): 1. http://dx.doi.org/10.5455/njppp.2024.14.08352202422082024.

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Digital therapeutics are evidence-based therapeutic interventions that utilize digital technologies to prevent, manage, or treat medical disorders. These interventions utilize digital technologies such as mobile applications or online platforms to deliver evidence-based therapeutic interventions and treatments for various health conditions. Digital therapeutics undergo rigorous clinical validation and regulatory processes to ensure their safety and efficacy. Digital therapeutics offer several benefits in health care, including improved accessibility, personalized treatment, cost-effectiveness,
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Lee, Ho-Jin. "Digital therapeutics in pain medicine." Korean Journal of Pain 34, no. 3 (2021): 247–49. http://dx.doi.org/10.3344/kjp.2021.34.3.247.

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Chung, Jae-Yong. "Digital therapeutics and clinical pharmacology." Translational and Clinical Pharmacology 27, no. 1 (2019): 6. http://dx.doi.org/10.12793/tcp.2019.27.1.6.

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Nakamura, Keisuke A., and Noori Kim. "Digital therapeutics in hearing healthcare." Journal of the Acoustical Society of America 155, no. 3_Supplement (2024): A35—A36. http://dx.doi.org/10.1121/10.0026703.

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Digital therapeutics (DTx) in hearing research have emerged as a new category of therapies that provide evidence-based intervention via digital means, such as software, smartphone apps, or websites. However, as they are relatively new, yet not well-established. In this presentation, we review DTx technologies in hearing research fields, focusing on three categories: prevention and diagnosis, aid (assistance), and curing (digital medicine). We observed that the majority of DTx systems require interactions with users (or patients) without clinical professionals’ direct support to obtain or colle
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Carrera, Alessandro, Emanuele Lettieri, Gaia Lietti, Sara Martignoni, Chiara Sgarbossa, and Joseph Cafazzo. "Therapies go digital. What drives physicians’ acceptance?" PLOS ONE 19, no. 5 (2024): e0303302. http://dx.doi.org/10.1371/journal.pone.0303302.

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National healthcare systems face multiple challenges, including the increasing demand for care and decreasing availability of healthcare professionals. Digital health technologies represent opportunities that offer improved efficiency, accessibility, and patient care. In this scenario, Digital Therapeutics are technological advancements to treat or alleviate a disease and deliver a medical intervention with evidence-based therapeutic impacts and regulatory approval. Digital Therapeutics are a paradigm shift for physicians, who exercise caution in terms of trust and wide usage. Digital Therapeu
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Kim, Soojin, Juhee Eom, and Jiwon Shim. "A Comparative Study on Intention to Use Digital Therapeutics: MZ Generation and Baby Boomers’ Digital Therapeutics Use Intention in Korea." International Journal of Environmental Research and Public Health 19, no. 15 (2022): 9556. http://dx.doi.org/10.3390/ijerph19159556.

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Purpose: The aim of this study lies in articulating the relationship between digital literacy and private concern as a predictor of intention to use digital therapeutics. Materials and Methods: An online survey was conducted through a research company among 600 panels. The survey questionnaire consists of items of digital literacy, privacy concern, perceptions, and intention to use digital therapeutics, and the participants were asked to fill out the questions online. A structural equation model was established, and the difference in paths between the MZ generation and the baby boomers were ex
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Gujrathi, Ashish. "Digital Therapeutics Hold a Promising Prospect in the Healthcare Sector – Explore How." Clinical Research and Clinical Trials 4, no. 3 (2021): 01–02. http://dx.doi.org/10.31579/2693-4779/060.

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The treatments of several diseases are evolving continuously towards a digital future indeed. Digital therapeutics use digital technologies to prevent, manage, or cure physical and mental health conditions. In the past ten years, the outcomes from digital therapeutics in a broad range of symptoms, such as cancer, ADHD, asthma, mental disorders, and insomnia have improved to a great extent, thereby making it more popular around the world.
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Kravchuk, A. A., E. I. Aksenova, and N. N. Kamynina. "DIGITAL THERAPY TECHNOLOGIES (LITERATURE REVIEW)." Problems of Social Hygiene, Public Health and History of Medicine 30, s1 (2022): 1038–43. http://dx.doi.org/10.32687/0869-866x-2022-30-s1-1038-1043.

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This article presents an analysis of international experience in the implementation of digital therapeutics technologies in health care. The features of digital therapeutics products: their distinction from digital health products and digital medicine are highlighted. An analysis of the global market for digital therapeutics is presented. The aspects of regulation of digital therapeutics and the barriers to its implementation are presented. The importance of digital therapeutics for the transition of health systems to a value-based management model is discussed.
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Maliha Mirza, Haniya Jabeen, and Ayesha Fatima. "Artificial Intelligence in Digital Therapeutics for Optimized Healthcare." Journal of Pharma Insights and Research 3, no. 2 (2025): 346–57. https://doi.org/10.69613/g5mbda64.

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Digital therapeutics (DTx) powered by artificial intelligence are reshaping modern healthcare by innovative ways of disease prevention, management, and treatment. The usage of machine learning, natural language processing, and computer vision enables DTx platforms to process patient data in real-time, predict health trajectories, and deliver personalized interventions. These intelligent systems optimize therapeutic efficacy based on individual patient responses while monitoring adherence and progress metrics to enhance clinical outcomes. In mental health applications, AI algorithms evaluate be
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Kim, Eun Joung, and Jung Yoon Kim. "The Metaverse for Healthcare: Trends, Applications, and Future Directions of Digital Therapeutics for Urology." International Neurourology Journal 27, Suppl 1 (2023): S3–12. http://dx.doi.org/10.5213/inj.2346108.054.

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In recent years, the emergence of digital therapeutics as a novel approach to managing conditions has garnered significant attention. This approach involves using evidence-based therapeutic interventions that are facilitated by high-quality software programs to treat, manage, or prevent medical conditions. The incorporation of digital therapeutics into the Metaverse has increased the feasibility of their implementation and application in all areas of medical services. In urology, substantial digital therapeutics are being produced and researched, including mobile apps, bladder devices, pelvic
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Ellis, Terry D., and Gammon M. Earhart. "Digital Therapeutics in Parkinson’s Disease: Practical Applications and Future Potential." Journal of Parkinson's Disease 11, s1 (2021): S95—S101. http://dx.doi.org/10.3233/jpd-202407.

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Digital therapeutics, treatments delivered remotely and enabled by modern technology, facilitate the provision of personalized, evidence-based, interdisciplinary interventions to manage the complexities associated with Parkinson’s disease. In the context of the COVID-19 pandemic, the need for digital therapeutics has arguably never been greater. However, despite new advances in technology and a heightened interest due to the pandemic, digital therapeutics remain underdeveloped and underutilized. In this paper, we briefly review practical applications and emerging advances in digital therapeuti
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Traynor, Kate. "Clinic finds benefits from digital therapeutics." American Journal of Health-System Pharmacy 75, no. 17 (2018): 1263–64. http://dx.doi.org/10.2146/news180055.

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Fassbender, Amelie, Shaantanu Donde, Mitchell Silva, et al. "Adoption of Digital Therapeutics in Europe." Therapeutics and Clinical Risk Management Volume 20 (December 2024): 939–54. https://doi.org/10.2147/tcrm.s489873.

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20

Makin, Simon. "The emerging world of digital therapeutics." Nature 573, no. 7775 (2019): S106—S109. http://dx.doi.org/10.1038/d41586-019-02873-1.

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Park, Jinyoung, and Jung Hyun Park. "Digital Therapeutics for the Musculoskeletal Disorders." Clinical Pain 21, no. 2 (2022): 74–79. http://dx.doi.org/10.35827/cp.2022.21.2.74.

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22

Graham, Andrea K., Emily G. Lattie, and David C. Mohr. "Experimental Therapeutics for Digital Mental Health." JAMA Psychiatry 76, no. 12 (2019): 1223. http://dx.doi.org/10.1001/jamapsychiatry.2019.2075.

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23

Salvatore, V. "The Regulatory Challenges of Digital Therapeutics." European Health & Pharmaceutical Law Review 7, no. 1 (2023): 29–35. http://dx.doi.org/10.21552/ehpl/2023/1/6.

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24

Kumar, Anika, Rita F. Redberg, Sanket S. Dhruva, and Joseph S. Ross. "Prescription Digital Therapeutics: The Authors Reply." Health Affairs 43, no. 6 (2024): 898. http://dx.doi.org/10.1377/hlthaff.2024.00278.

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25

Lichtenstein, David P. "Digital therapeutics: don't be afraid — yet." Brown University Child and Adolescent Behavior Letter 41, no. 7 (2025): 8. https://doi.org/10.1002/cbl.30882.

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Morton Peppercorn (not his real name, but it was memorably unique) was a graduate student therapist whose story was told during my doctoral training. Morton worked hard with one client struggling with depression. In time, the client's symptoms improved, and Morton inquired about what had made the difference. Was it the cognitive restructuring? Behavioral activation? “No,” said the client. “I noticed one day that you had a hole in your shoe. I realized that if this guy has a hole in his shoe, then maybe my life isn't so bad in comparison.”
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26

Dahlhausen, Florian, Maximillian Zinner, Linn Bieske, Jan P. Ehlers, Philip Boehme, and Leonard Fehring. "There's an app for that, but nobody's using it: Insights on improving patient access and adherence to digital therapeutics in Germany." DIGITAL HEALTH 8 (January 2022): 205520762211046. http://dx.doi.org/10.1177/20552076221104672.

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Background Mobile health applications and their subset digital therapeutics—defined as evidence-based software interventions to prevent, manage, or treat a medical condition—offer great potential to improve patient care. However, such solutions often struggle to reach widespread adoption. Objective This study seeks to explore healthcare stakeholders’ roles and potential for fostering patient access and adherence to evidence-based digital therapeutics and thereby improve health outcomes from the perspective of digital therapeutics developers and distributors. Methods Semi-structured qualitative
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27

van Kessel, Robin, Andres Roman-Urrestarazu, Michael Anderson, et al. "Mapping Factors That Affect the Uptake of Digital Therapeutics Within Health Systems: Scoping Review." Journal of Medical Internet Research 25 (July 25, 2023): e48000. http://dx.doi.org/10.2196/48000.

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Background Digital therapeutics are patient-facing digital health interventions that can significantly alter the health care landscape. Despite digital therapeutics being used to successfully treat a range of conditions, their uptake in health systems remains limited. Understanding the full spectrum of uptake factors is essential to identify ways in which policy makers and providers can facilitate the adoption of effective digital therapeutics within a health system, as well as the steps developers can take to assist in the deployment of products. Objective In this review, we aimed to map the
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28

Damodaran, Pavithran. "P047 DIGITAL THERAPEUTICS FOR HYPERTENSION MANAGEMENT: A REVIEW." Journal of Hypertension 42, Suppl 3 (2024): e71. http://dx.doi.org/10.1097/01.hjh.0001063060.08360.02.

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Background and Objective: Digital therapeutics have emerged as a viable approach to manage chronic conditions, including hypertension. This review evaluates the effectiveness of digital therapeutic interventions in hypertension management. Methods A literature review was conducted on studies published from 2010 to 2023, focusing on digital health tools such as mobile apps, wearable devices, and telemonitoring systems. Data was extracted from PubMed, Cochrane Library, and IEEE Xplore. Results Digital health interventions, including smartphone apps for BP monitoring and lifestyle modification, r
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Aisha Katsina Isa. "Exploring digital therapeutics for mental health: AI-driven innovations in personalized treatment approaches." World Journal of Advanced Research and Reviews 24, no. 3 (2024): 2733–49. https://doi.org/10.30574/wjarr.2024.24.3.3997.

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Digital therapeutics have emerged as a transformative approach in addressing mental health challenges, offering evidence-based, technology-driven interventions. As mental health disorders become increasingly prevalent globally, traditional methods of treatment often fail to meet the growing demand due to limited accessibility, stigmatization, and resource constraints. Digital therapeutics leverage advanced technologies, including artificial intelligence (AI), to bridge these gaps, providing scalable and personalized mental health solutions. AI has revolutionized this domain by enabling adaptiv
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Aisha, Katsina Isa. "Exploring digital therapeutics for mental health: AI-driven innovations in personalized treatment approaches." World Journal of Advanced Research and Reviews 24, no. 3 (2024): 2733–49. https://doi.org/10.5281/zenodo.15241622.

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Digital therapeutics have emerged as a transformative approach in addressing mental health challenges, offering evidence-based, technology-driven interventions. As mental health disorders become increasingly prevalent globally, traditional methods of treatment often fail to meet the growing demand due to limited accessibility, stigmatization, and resource constraints. Digital therapeutics leverage advanced technologies, including artificial intelligence (AI), to bridge these gaps, providing scalable and personalized mental health solutions. AI has revolutionized this domain by enabling adaptiv
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Sang-Yoon, Park. "Teledentistry and Digital Therapeutics (DTx) for dentistry." Journal of Clinical Advances in Dentistry 6, no. 1 (2022): 028–30. http://dx.doi.org/10.29328/journal.jcad.1001029.

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32

Liu, Michelle, and Stephen M. Schueller. "Integrating Digital Therapeutics With Mental Healthcare Delivery." Journal of Health Service Psychology 50, no. 2 (2024): 77–85. http://dx.doi.org/10.1007/s42843-024-00105-3.

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Han, Young-min. "Role and Regulatory Status of Digital Therapeutics." Annals of CardioPulmonary Rehabilitation 4, no. 2 (2024): 44–48. https://doi.org/10.53476/acpr.2024.4.2.44.

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Bedbrook, Robert, and Zachary Byfield. "Digital therapeutics in the primary healthcare setting." Contemporary Nurse 54, no. 4-5 (2018): 421–24. http://dx.doi.org/10.1080/10376178.2018.1512373.

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Weiss, Margaret D. "12.3 Digital Therapeutics and Solutions for ADHD." Journal of the American Academy of Child & Adolescent Psychiatry 62, no. 10 (2023): S19. http://dx.doi.org/10.1016/j.jaac.2023.07.190.

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36

Joshi, M., and A. Dcruz. "MT22 Value Assessment of Prescription Digital Therapeutics." Value in Health 26, no. 6 (2023): S301. http://dx.doi.org/10.1016/j.jval.2023.03.1669.

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Jeon, Jin Yong. "Soundscape and Digital Therapeutics: Psycho-physiological Restoration." INTER-NOISE and NOISE-CON Congress and Conference Proceedings 265, no. 1 (2023): 6728–36. http://dx.doi.org/10.3397/in_2022_1011.

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The psychological and physiological indicators derived from studies of urban soundscapes have been suggested to explain the restoration effects of digital treatments using virtual reality (VR) environments. These experiences of virtual spaces that lead to emotional restoration are often related to natural environments such as waterfront and sites with vegetations. Perceptions of VR environments demonstrated that urban areas, including urban parks with traffic noise in the background were also considered as such spaces. VR technology used for experiencing spatial atmospheres creates a realistic
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Athreya, Arjun, Paul Croarkin, William Bobo, and Magdalena Romanowicz. "Digital Therapeutics for Precision Medicine in Psychiatry." Biological Psychiatry 95, no. 10 (2024): S72. http://dx.doi.org/10.1016/j.biopsych.2024.02.174.

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Kim, Hee-Jin, Kyung Min Kim, Byung-Su Kim, et al. "Latest Trends in Digital Therapeutics for Neurology." Journal of the Korean Neurological Association 43, no. 3 (2025): 142–52. https://doi.org/10.17340/jkna.2025.0027.

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As societies age rapidly, the long-term medical and economic burdens of major neurological diseases -such as Alzheimer’s disease, Parkinson’s disease, and stroke- are increasing. Digital therapeutics (DTx), defined as evidence-based therapeutic interventions delivered via software for disease prevention, management, or treatment, are emerging as a novel paradigm in neurology. Unlike general health apps, DTx are developed for medical purposes and require clinical validation and regulatory approval. As of 2025, over 500 DTx products have been approved globally, including in the United States, Ch
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Sverdlov, Oleksandr, Joris van Dam, Kristin Hannesdottir, and Tricia Thornton-Wells. "Digital Therapeutics: An Integral Component of Digital Innovation in Drug Development." Clinical Pharmacology & Therapeutics 104, no. 1 (2018): 72–80. http://dx.doi.org/10.1002/cpt.1036.

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41

Lee, Ki-Ho, and Kye-Hyun Kim. "Current status and implications of legislation related to digital therapeutics." Wonkwang University Legal Research Institute 29 (June 30, 2023): 115–40. http://dx.doi.org/10.22397/bml.2022.29.115.

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With the development of the digital healthcare sector, the software itself has now become a medical device. Digital Therapeutics(DTx) are defined as “providing evidence-based treatment interventions driven by high-quality software programs to prevent, manage, or treat medical disorders or diseases.” With the spread of digital therapeutics(DTx), major countries are expanding government-level support and investment, and overhauling related laws.
 This study examined the current status of domestic and foreign digital therapeutics and identified related laws and regulatory trends. Based on th
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42

Park, Jin Young. "Current status and future development of digital therapeutics." Journal of the Korean Medical Association 67, no. 2 (2024): 76–82. http://dx.doi.org/10.5124/jkma.2024.67.2.76.

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Background: Digital therapeutics, evidence-based software applications, offer preventive measures for various diseases and enhance healthcare accessibility and change. This article explores the current status and future trajectory of these devices.Current Concepts: Digital therapeutics prioritize a patient-centered approach. Historically, healthcare relied heavily on prescribed treatments during hospital visits. However, these devices provide objective data on patient symptoms through real-time digital monitoring. They also foster advancements in biotechnology and information technology, leadi
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Lee, Choong-Young. "Digital Therapeutics Using Brain Waves XR Research on How to Create Contents." Korean Journal of animation 16, no. 4 (2020): 197–209. http://dx.doi.org/10.51467/asko.2020.12.16.4.197.

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44

Mogk, Jessica, Abisola E. Idu, Jennifer F. Bobb, et al. "Prescription Digital Therapeutics for Substance Use Disorder in Primary Care: Mixed Methods Evaluation of a Pilot Implementation Study." JMIR Formative Research 8 (September 2, 2024): e59088. http://dx.doi.org/10.2196/59088.

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Background Delivering prescription digital therapeutics (ie, evidence-based interventions designed to treat, manage, or prevent disorders via websites or smartphone apps) in primary care could increase patient access to substance use disorder (SUD) treatments. However, the optimal approach to implementing prescription digital therapeutics in primary care remains unknown. Objective This pilot study is a precursor to a larger trial designed to test whether implementation strategies (practice facilitation [PF] and health coaching [HC]) improve the delivery of prescription digital therapeutics for
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Giancaterini, A. "Digital therapeutics: the innovation that will transform healthcare." Journal of AMD 28, no. 1-2 (2025): 37. https://doi.org/10.36171/jamd25.28.1-2.6.

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Le Terapie Digitali (DTx) rappresentano un’innovazione nel trattamento delle malattie croniche e dei disturbi mentali. Sono software con valore terapeutico e, rispetto alle app di salute gene­riche, sono prescrivibili dai medici dopo approva­zione degli enti regolatori a seguito di rigorosi studi clinici (RCT). Integrano Intelligenza Artificiale (IA) e strumenti digitali per fornire cure personalizzate e migliorare l’aderenza terapeutica. Le DTx possono essere: Stand alone (autonome), As­sociate (integrate con altri trattamenti), Combinate (in­sieme a farmaci specifici). Devono rispettare stan
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Yu, In-Geun, and Sun-Ki Hong. "Research on legal issues and legal improvements in the emergence of Digital Therapeutics: Focusing on the introduction of the concept of 'Digital Therapeutics game product'." Wonkwang University Legal Research Institute 31 (June 30, 2024): 205–32. http://dx.doi.org/10.22397/bml.2024.31.205.

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This study aims to review and improve the current legal issues related to the emergence of Digital Therapeutics. First, we reviewed the scope of the Game Industry Promotion Act (Game Industry Act) and what regulations are made under the Game Industry Act. In particular, the scope of application of the Game Industry Act is the same as whether or not a game falls under Article 2(1) of the Game Industry Act, and we found that the concept of a game is used in a broad sense both in literature and in practice. In other words, there have been precedents in which content in the field of education and
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Menon, Vidya. "Artificial Intelligence in Digital Therapeutics: Exploring the Tangled Web of Legal Issues." Chettinad Health City Medical Journal 13, no. 01 (2024): 102–7. http://dx.doi.org/10.24321/2278.2044.202418.

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Lee, Dongwon, and Yeo Jin Kim. "Current trends and future perspectives on digital therapeutics." Journal of the Korean Medical Association 68, no. 4 (2025): 235–39. https://doi.org/10.5124/jkma.25.0033.

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Purpose: This review explores the current status and future potential of digital therapeutics (DTx), emphasizing their role in clinical practice. It focuses on clarifying their classification, clinical applications, regulatory challenges, and prospective developments in the field.Current Concepts: Digital therapeutics are evidence-based interventions delivered via software to prevent, manage, and treat medical conditions. Unlike traditional pharmacotherapy, DTx products can be updated and modified, offering greater flexibility in treatment delivery. They are categorized into behavior-modificat
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Kim, Yoon-Soo, Tae-Woong Seo, and Hayoung Oh. "Implementation of Suicide Prevention Digital Therapeutics Using Digital Humans and Prediction Model." Journal of the Korea Institute of Information and Communication Engineering 28, no. 4 (2024): 467–77. http://dx.doi.org/10.6109/jkiice.2024.28.4.467.

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Jharbade,, Dr Ruchika. "Digital Therapeutics: Transforming Healthcare Through AI & Emerging Technology." IOSR Journal of Dental and Medical Sciences 24, no. 1 (2025): 40–49. https://doi.org/10.9790/0853-2401014049.

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The integration of Artificial Intelligence (AI) into Digital Therapeutics (DTx) has emerged as a transformative trend in healthcare, offering innovative solutions for the management, treatment, and prevention of various medical conditions. DTx, defined as clinically validated software-based therapeutic interventions, are increasingly leveraging AI technologies, including machine learning, deep learning, and advanced data analytics, to enhance their efficacy, personalization, and scalability. This literature review explores the state-ofthe-art developments in AI-driven DTx, focusing on key appl
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