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Journal articles on the topic 'Dihydrochloride'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Carlson, Mark. "Azimilide dihydrochloride." Expert Review of Cardiovascular Therapy 3, no. 3 (2005): 387–91. http://dx.doi.org/10.1586/14779072.3.3.387.

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2

Yang, Lily P. H., and Caroline M. Perry. "Histamine Dihydrochloride." Drugs 71, no. 1 (2011): 109–22. http://dx.doi.org/10.2165/11206410-000000000-00000.

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3

Kennedy, Stanley W., Peter K. Schultz, Phillip G. Slade, and Edward R. T. Tiekink. "Triethylenediamine dihydrochloride." Zeitschrift für Kristallographie 180, no. 1-4 (1987): 211–17. http://dx.doi.org/10.1524/zkri.1987.180.1-4.211.

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4

Betz, Richard, Thomas Gerber, Eric Hosten, Budanoor P. Siddaraju, and Hemmige S. Yathirajan. "Opipramol dihydrochloride." Acta Crystallographica Section E Structure Reports Online 67, no. 11 (2011): o2994—o2995. http://dx.doi.org/10.1107/s1600536811042280.

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5

McIntyre, J. A., J. Castañer, and P. A. Leeson. "Canertinib Dihydrochloride." Drugs of the Future 30, no. 8 (2005): 771. http://dx.doi.org/10.1358/dof.2005.030.08.927254.

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6

Reviriego, C. "Daclatasvir dihydrochloride." Drugs of the Future 36, no. 10 (2011): 735. http://dx.doi.org/10.1358/dof.2011.036.10.1703570.

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7

Reviriego, C. "Daclatasvir dihydrochloride." Drugs of the Future 36, no. 10 (2011): 735. http://dx.doi.org/10.1358/dof.2011.36.10.1703570.

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8

Ravindra S Morey, Ganesh G Tapadiya, and Manisha V Doud. "Development and validation of stability indicating HPTLC method for estimation of Daclatasvir Dihydrochloride in pharmaceutical dosage form." World Journal of Advanced Research and Reviews 23, no. 2 (2024): 2470–78. http://dx.doi.org/10.30574/wjarr.2024.23.2.2569.

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A high-performance thin-layer chromatographic method was developed and validated for estimation of Daclatasvir Dihydrochloride in pharmaceutical dosage form. The proposed method was applied successfully to the pharmaceutical analysis of the recently approved dosage form of Daclatasvir Dihydrochloride which is available in market as a brand name of ‘NALDAC 60’ tablets. The drugs were satisfactorily show peak with RF 0.38 for Daclatasvir Dihydrochloride. Method was validated according to the ICH guidelines. The calibration plot was linear between 50-300 ng per band for Daclatasvir Dihydrochlorid

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9

Ravindra, S. Morey, G. Tapadiya Ganesh, and V. Doud Manisha. "Development and validation of stability indicating HPTLC method for estimation of Daclatasvir Dihydrochloride in pharmaceutical dosage form." World Journal of Advanced Research and Reviews 23, no. 2 (2024): 2470–78. https://doi.org/10.5281/zenodo.14891592.

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A high-performance thin-layer chromatographic method was developed and validated for estimation of Daclatasvir Dihydrochloride in pharmaceutical dosage form. The proposed method was applied successfully to the pharmaceutical analysis of the recently approved dosage form of Daclatasvir Dihydrochloride which is available in market as a brand name of ‘NALDAC 60’ tablets. The drugs were satisfactorily show peak with RF 0.38 for Daclatasvir Dihydrochloride. Method was validated according to the ICH guidelines. The calibration plot was linear between 50-300 ng per band for Daclatasvir Di

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10

Beatrix, Shella, Gilny Aileen Joan, and Denny Ricky. "PENGGUNAAN ANTISEPTIK ALKOHOL 70% DAN OCTENIDINE DIHYDROCHLORIDE 0,1% PADA PROSEDUR PEMASANGAN INFUS UNTUK MENCEGAH PHLEBITIS." Jurnal Skolastik Keperawatan 3, no. 1 (2017): 25. http://dx.doi.org/10.35974/jsk.v3i1.583.

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ABSTRAK Pendahuluan: Antiseptik alkohol merupakan cairan antiseptik yang sering digunakan sebelum penusukan infus dalam pencegahan masuknya mikroorganisme. Pemberian antiseptik lain untuk kulit adalah Octenidine Dihydrochloride 0,1% yang terbukti efektif dalam melawan berbagai macam mikroorganisme, penutupan luka, dan tidak beracun. Octenidine Dihydrochloride 0,1% biasanya tidak dipakai dalam pengolesan antiseptik sebelum penusukan infus. Metode: Penelitian ini menggunakan metode eksperimen dengan Post-Test Only Design dan sampel dipilih dengan menggunakan metode Purposive sampling Hasil: Pero

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11

Blazheyevskiy, Mykola, and Valeriy Moroz. "Iodometric determination of cystamine dihydrochloride in tablets using diperoxyadipic acid." French-Ukrainian Journal of Chemistry 8, no. 1 (2020): 19–27. http://dx.doi.org/10.17721/fujcv8i1p19-27.

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The kinetics of cystamine dihydrochloride oxidation by diperoxyadipic acid (DPAA) was studied in aqueous buffer solutions of pH 2.9, 6.9, 8.0, 8.5 and 9.2 under second-order conditions at the temperature 293 K. The second order rate constants, k (L mol−1 min−1) were calculated from kinetic values. A suitable mechanism scheme based on these observations was proposed. The possibility of application of DPAA as reagent for oxidimetric determination of cystamine dihydrochloride in tabtets was investigated. Cystamine dihydrochloride was determined by indirect titration with DPAA. The required amount

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12

Patel, Palak, and Kashyap K. Bhatt. "Development and Validation of HPTLC Method for Estimation of Propranolol Hydrochloride and Flunarizine Dihydrochloride in Combined Dosage Form." ISRN Analytical Chemistry 2012 (July 9, 2012): 1–6. http://dx.doi.org/10.5402/2012/502604.

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A simple, sensitive, and precise high-performance thin layer chromatographic method has been developed for the estimation of propranolol hydrochloride and Flunarizine dihydrochloride in combined dosage form. The method employed HPTLC aluminum plates precoated with silica gel 60F as the stationary phase while the solvent system was toluene:methanol: ethyl acetate: acetic acid (7 : 1.5 : 1.5 : 0.1 v/v/v/v). The Rf value was observed to be 0.07±0.02 and 0.67±0.02 for propranolol hydrochloride and flunarizine dihydrochloride. The densitometric analysis was carried out in absorbance mode at 240 nm.

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13

Cada, Dennis J., Terri Levien, and Danial E. Baker. "Sapropterin Dihydrochloride Tablets." Hospital Pharmacy 43, no. 4 (2008): 307–14. http://dx.doi.org/10.1310/hpj4304-307.

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14

Bats, Jan W., Hamid Reza Nasiri, and Harald Schwalbe. "Isoguanine dihydrochloride dihydrate." Acta Crystallographica Section E Structure Reports Online 62, no. 5 (2006): o2040—o2042. http://dx.doi.org/10.1107/s1600536806014061.

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The crystal structure of the title compound, 6-amino-2-oxo-1,2-dihydro-9H-purine-3,7-diium dichloride dihydrate, C5H7N5O2+·2Cl−·2H2O, consists of hydrogen-bonded layers parallel to (10\overline{1}). In addition, pairs of layers are connected by an O—H...Cl hydrogen bond and there are also short Cl...C and Cl...N contacts between the layers.

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15

Selmeczi, Katalin, Patrick Gizzi, Emmanuel Wenger, and Bernard Henry. "L-Alanylglycylhistamine dihydrochloride." Acta Crystallographica Section E Structure Reports Online 68, no. 6 (2012): o1917—o1918. http://dx.doi.org/10.1107/s1600536812023562.

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In the title compound {systematic name: 4-[2-({N-[(2S)-2-ammoniopropanoyl]glycyl}amino)ethyl]-1H-imidazol-3-ium dichloride}, C10H19N5O2 2+·2Cl−, the pseudo-tripeptide L-alanylglycylhistamine is protonated at both the terminal amino group and the histidine N2 atom. The resulting positive charges are neutralized by two chloride anions. In the crystal, the organic cation adopts a twisted conformation about the CH2—CH2 bond of histamine and about the C—N bond in the main chain, stabilized by a short intramolecular C—H...O contact. In the crystal, N+—H...O and N+—H...Cl− hydrogen bonds link the mol

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16

Yousefi, Behrooz H., and Ulrich Jordis. "4,4'-Diethylaminoethoxyhexestrol dihydrochloride." Molbank 2006, no. 6 (2006): M511. http://dx.doi.org/10.3390/m511.

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17

Abramovits, William, and Aditya Gupta. "Xyzal (levocetirizine dihydrochloride)." SKINmed 7, no. 2 (2008): 84–85. http://dx.doi.org/10.1111/j.1751-7125.2008.08173.x.

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18

Belikova, Anastasiia, Liudas Ivanauskas, Lyudmila Sidorenko, et al. "Study of the degradation behavior of enisamium iodide, tilorone dihydrochloride, morpholinium thiazotate in the soil by the GC-Fid method." ScienceRise: Pharmaceutical Science, no. 2 (48) (April 30, 2024): 12–18. http://dx.doi.org/10.15587/2519-4852.2024.300209.

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The aim. To study the behaviour of enisamium iodide, thiloron dihydrochloride, morpholinium thiazotate, and the suitability of the previously developed GC-FID methodology in soil. Materials and methods. The determination of the Enisamium iodide, Tilorone dihydrochloride, and Morpholinium thiazotate in soil gas chromatography with a flame ionization detector using the Rxi-5 ms (30 m long, 0.25 mm outer diameter and 0.25 μm liquid stationary phase thickness). Results. A study was conducted on the behaviour of enisamium iodide, thiloron dihydrochloride, and morpholinium thiazotate in soil, along

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19

Chhalotiya, Usmangani K., Kashyap K. Bhatt, Dimal A. Shah, Gautam R. Chauhan, and Sunil L. Baldania. "Development of LC Method for the Simultaneous Determination of Antidepressant Drug Combination Melitracen Hydrochloride and Flupentixol Dihydrochloride in their Combined Dosage Form." Chromatography Research International 2011 (June 16, 2011): 1–6. http://dx.doi.org/10.4061/2011/632820.

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A simple, specific and stability-indicating reversed-phase high-performance liquid chromatographic method was developed for the simultaneous determination of melitracen hydrochloride and flupentixol dihydrochloride in tablet dosage form. A Brownlee C-18, 5 μm column having 250×4.6 mm i.d. in isocratic mode, with mobile phase containing 0.025 M potassium dihydrogen phosphate: methanol (10 : 90, v/v; pH 7.3) was used. The flow rate was 1.0 mL/min, and effluents were monitored at 230 nm. The retention times of melitracen hydrochloride and flupentixol dihydrochloride were 7.75 min and 5.50 min, re

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20

Blazheyevskiy, Mykola, Myhailo Kucher, and Oleh Shpychak. "The quantitative determination of Perphenazine in tablets by the spectrophotometric method as its sulfoxide obtained with diperoxyazelaic acid." French-Ukrainian Journal of Chemistry 7, no. 2 (2019): 96–103. http://dx.doi.org/10.17721/fujcv7i2p96-103.

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The oxidative derivatization method using diperoxyazelaic acid for the indirect spectrophotometric determination of Perphenazine dihydrochloride is presented. Diperoxyazelaic acid is introduced as a derivatizing agent for Perphenazine, yielding sulfoxides. This reaction product was successfully employed for the spectrophotometric determination of Perphenazine dihydrochloride. The UV spectroscopic detection of sulfoxide has been proven to be the more robust and selective. The method developed allowed determination of Perphenazine dihydrochloride in the concentration range of 1–40 µg/mL. The lim

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21

Anandakumar, K., and P. Veerasundari. "Simultaneous Estimation of Paracetamol, Ambroxol Hydrochloride, Levocetirizine Dihydrochloride, and Phenylephrine Hydrochloride in Combined Tablet Formulation by First-Order Derivative Spectrophotometry." ISRN Spectroscopy 2014 (March 30, 2014): 1–8. http://dx.doi.org/10.1155/2014/248960.

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Paracetamol, ambroxol hydrochloride, levocetirizine dihydrochloride, and phenylephrine hydrochloride are used in combination for the treatment of chronic sinusitis, rhinitis, fever, nasal discharge, sore throat, and wheezing. The present work deals with method development for simultaneous estimation of paracetamol, ambroxol hydrochloride, levocetirizine dihydrochloride, and phenylephrine hydrochloride in tablet formulation by first-order derivative spectrosphotometry. For determination of sampling wavelength, 10 μg/mL of each of paracetamol, ambroxol hydrochloride, levocetirizine dihydrochlori

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22

Denysov, Yevhen, and Gennadii Putyatin. "Innovative opportunities of pharmakotherapy of generalized anxiety disorder." Ukrains'kyi Visnyk Psykhonevrolohii, Volume 32, Issue 2 (119), 2024 (July 1, 2024): 32–37. http://dx.doi.org/10.36927/2079-0325-v32-is2-2024-5.

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The work shows the actual problem and proven effectiveness of treatment of generalized anxiety disorder (GAD), including its modern methods. There was an open-label, 6-week study of the efficacy, safety, and tolerability of opipramol dihydrochloride 200 mg/day to evaluate an innovative method of treatment the patients with GAD. The conducted study demonstrates the rapid and powerful anxiolytic effect of opipramol dihydrochloride in the treatment of general, mental and somatic anxiety in patients with GAD. Opipramol dihydrochloride demonstrates a reliable fast and strong vegetative-stabilizing

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23

Uygur, Fatih, Mustafa Özyurt, Rahmi Evinç, Tugrul Hosbul, Bahattin Çeliköz, and Tuncer Haznedaroglu. "Comparison of octenidine dihydrochloride (Octenisept®), polihexanide (Prontosan®) and povidon iodine (Betadine®) for topical antibacterial effects in Pseudomonas aeruginosa-contaminated, full-skin thickness burn wounds in rats." Open Medicine 3, no. 4 (2008): 417–21. http://dx.doi.org/10.2478/s11536-008-0042-x.

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AbstractPseudomonas aeruginosa is one of the most frequently isolated organisms from infected burn wounds and a significant cause of nosocomial infection and septic mortality among burn patients. In this animal study, three antiseptic agents which were Octenidine dihydrochloride (Octenisept®, Schülke & Mayr, Norderstedt, Germany), polyhexanide (Prontosan®, B. Braun, Melsungen AG, Germany) and povidon iodine (Betadine, Purdue Pharma L.P, Stamford, USA) were compared to assess the antiseptic effect of their applications on experimental burn wounds in in rats contaiminated with P. aeruginosa.

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24

Lynch, Daniel E., and Ian McClenaghan. "8-Hydrazinoquinoline dihydrochloride hydrate." Acta Crystallographica Section E Structure Reports Online 58, no. 10 (2002): o1070—o1071. http://dx.doi.org/10.1107/s1600536802015878.

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25

Petrus, Joanna, Rafał Petrus, and Bogusława Czarnik-Matusewicz. "Fluphenazine dihydrochloride dimethanol solvate." Acta Crystallographica Section E Structure Reports Online 68, no. 4 (2012): o1004—o1005. http://dx.doi.org/10.1107/s1600536812008707.

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In the title compound {systematic name: 1-(2-hydroxyethyl)-4-[3-(2-trifluoromethyl-10H-phenothiazin-10-yl)propyl]piperazine-1,4-diium dichloride dimethanol disolvate}, C22H28F3N3OS2+·2Cl−·2CH3OH, the dihedral angle between the planes of the two outer benzene rings of the tricyclic phenothiazine system is 46.91 (13)°. The piperazine ring adopts a chair conformation. The crystal structure is stabilized by O—H...Cl, N—H...Cl, C—H...O, C—H...Cl and C—H...F hydrogen bonds and contacts.

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26

Kumar, A., and D. Strech. "Zuclopenthixol Dihydrochloride for Schizophrenia." Schizophrenia Bulletin 35, no. 5 (2009): 855–56. http://dx.doi.org/10.1093/schbul/sbp077.

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27

Henck, Jan‐Olav, Emil Finner, and Artur Burger. "Polymorphism of Tedisamil Dihydrochloride." Journal of Pharmaceutical Sciences 89, no. 9 (2000): 1151–59. http://dx.doi.org/10.1002/1520-6017(200009)89:9<1151::aid-jps7>3.0.co;2-e.

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28

Henck, Jan‐Olav, Emil Finner, and Artur Burger. "Polymorphism of tedisamil dihydrochloride." Journal of Pharmaceutical Sciences 89, no. 9 (2000): 1151–59. http://dx.doi.org/10.1002/1520-6017(200009)89:9<1151::aid-jps7>3.3.co;2-5.

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29

Wieczorek, Micha? W., Danuta Kalemba, and J�zef G�ra. "Crystal and molecular structures of (�)cadinene dihydrochloride (1) and (?)cadinene dihydrochloride (2)." Journal of Crystallographic and Spectroscopic Research 22, no. 5 (1992): 557–62. http://dx.doi.org/10.1007/bf01161340.

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30

Armitage, M. A., and D. Saunders. "Synthesis of 2-[2-14C]-(2-aminoethyl)-thiazole dihydrochloride: Thiazolyl ethylamine dihydrochloride." Journal of Labelled Compounds and Radiopharmaceuticals 22, no. 10 (1985): 1075–80. http://dx.doi.org/10.1002/jlcr.2580221010.

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31

Zhang, Bei Long, Hong Hai Huang, Wei Yong Deng, Yong Zhou Wang, Li Ding, and Ping Yue Wang. "Effect of Tackifier on Thermal Oxidation Kinetics and Effective Storage Time of Raw Natural Rubber." Advanced Materials Research 898 (February 2014): 102–6. http://dx.doi.org/10.4028/www.scientific.net/amr.898.102.

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The thermal oxidation kinetics of natural rubber containing hydrazine dihydrochloride or hydrazine sulfate used as tackifier were studied, and the effective storage time of natural rubber containing tackifier was predicted with a method of heat accelerated storage aging. The results show that the thermal oxidation activation energy of natural rubber containing hydrazine dihydrochloride is 105.6kJ/ mol, being a little higher than that (104.7 kJ/ mol) of the control. The thermal oxidation activation energy of natural rubber containing hydrazine sulfate is 103.1kJ/ mol, being a little lower than

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32

Pantelic, Nebojsa, Bojana Zmejkovski, Tatjana Stanojkovic, et al. "Synthesis and high in vitro cytotoxicity of some (S,S)-ethylenediamine-N,N’-di-2-propanoate dihydrochloride esters." Journal of the Serbian Chemical Society 79, no. 6 (2014): 649–58. http://dx.doi.org/10.2298/jsc130512022p.

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Novel (S,S)-R2eddip ester, O,O?-diisoamyl-(S,S)-ethylenediamine-N,N?-di-2-propanoate dihydrochloride, 1, was synthesized and characterized by IR, 1H and 13C NMR spectroscopy, mass spectroscopy and elemental analysis.In vitro antitumor action of 1, and two more R2eddip esters, O,O?-dialkyl-(S,S)-ethylenediamine-N,N?-di-2-propanoate dihydrochlorides, obtained before, (alkyl = n-Bu, n-Pe; 2 and 3, respectively), was determined against cervix adenocarcinoma (HeLa), human melanoma (Fem-x), human chronic myelogenous leukemia (K562) cells, and a non-cancerous cell line human embryonic lung fibroblast

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33

Mulinari, Eduardo, Nayara Castelano Brito, and Lays Pires Marra. "PP14 Budget Impact Of Sapropterin Dihydrochloride For Phenylketonuria." International Journal of Technology Assessment in Health Care 35, S1 (2019): 40. http://dx.doi.org/10.1017/s0266462319001880.

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IntroductionThe National Committee for Health Technology Incorporation (CONITEC) evaluates health technologies to recommend their inclusion or exclusion within the Brazilian Public Health System (SUS), and uses the budget impact assessment to estimate costs to the system. The Ministry of Health (MS) guideline recommends treatment of phenylketonuria (PKU) with restricted phenylalanine diet and phenylalanine-free amino acid formula (PFAAf) supplementation. CONITEC evaluated the inclusion of sapropterin dihydrochloride for PKU in the SUS.MethodsThe population eligible for treatment was evaluated

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34

Elmes, BC, G. Holan, GT Wernert, and DA Winkler. "The Synthesis of Bisguanidinoalkanes and Guanidinoalkanes, N- or N'-Substituted With Pyrimidines, as Analogues of Chlorhexidine." Australian Journal of Chemistry 49, no. 5 (1996): 573. http://dx.doi.org/10.1071/ch9960573.

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A series of N,N???- alkanediylbis [N?-(5-halopyrimidin-2-yl)guanidine] salts has been synthesized along with N,N???-(trans-cyclohexane-1,4-diyl) bis [N'-(5-chloropyrimidin-2-yl)guanidine], N,N???-(cis-cyclohexane-1,4-diyl) bis [N?-(5-chloropyrimidin-2-yl)guanidine] dihydrochloride and N-(cis-4-amino-cyclohexan-1-yl)-N'-(5-chloropyrimidin-2-yl)guanidine dihydrochloride . Furthermore, a series of N-(alkan-1-yl)-N?-(5-chloropyrimidin-2yl)guanidine hydrochlorides and N-(6-aminohexan-1-yl)-N?-(5-chloropyrimidin-2-yl)guanidine dihydrochloride were synthesized. This series of compounds was prepared b

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35

Islam, Asraful, Shimul Halder, and Sitesh Chandra Bachar. "Formulation and in vitro Evaluation of Betahistine Dihydrochloride Twice Daily Controlled Release Matrix Tablet." Dhaka University Journal of Pharmaceutical Sciences 10, no. 2 (2012): 93–100. http://dx.doi.org/10.3329/dujps.v10i2.11786.

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In order to reduce dosing frequency, a sustained release dosage form of betahistine dihydrochloride was developed as a twice daily controlled release tablet formulation that could be used to decrease vertigo resulted in Meniere's disease for a prolonged time. Six formulations were developed by using Methocel K4M CR, Methocel K15M CR and Methocel K 100 LVCR as single and combinations in different percentage. The tablets were prepared by wet granulation method. Physical properties of betahistine dihydrochloride granules and betahistine dihydrochloride matrix tablets were evaluated. The tablets w

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36

Jena, Tapan Kumar, and Rakesh Kumar Jat. "Characterization of Sapropterin Dihydrochloride Tablet." Journal of Drug Delivery and Therapeutics 14, no. 6 (2024): 109–13. http://dx.doi.org/10.22270/jddt.v14i6.6599.

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Characterization of Kuvan tablets involved thorough analysis of physical, chemical, and dissolution properties. Formulation development encompassed pre-formulation studies, feasibility trials, and process optimization. Kuvan tablets demonstrated variability in sapropterin dihydrochloride concentration but rapid dissolution across different media. Consistent mechanical strength, low impurity levels, and appropriate pH values were observed, ensuring efficacy, safety, and reliability. Keywords: Sapropterin dihydrochloride, Hyperphenylalaninemia, Kuvan tablets

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37

Rahmawati, Lidya, Sandra Pebrianti, and Hesti Platini. "Perubahan Perbaikan Luka Abses DM Post Debridemen Selama Perawatan Luka dengan Octenidine Dihydrochloride : Laporan Kasus." MAHESA : Malahayati Health Student Journal 3, no. 8 (2023): 2575–87. http://dx.doi.org/10.33024/mahesa.v3i8.10951.

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ABSTRACT Diabetes mellitus is a chronic disease caused by insulin resistance and can cause complications, one of which is an abscess. surgical debridement is the initial medical treatment for abscesses that cause injury. wound care is needed to speed up the healing process, reduce the risk of infection, and absorb wound fluid. Purpose of this paper is to find out how the development of the debridemen wound repair with diabetes on the left shoulder. Used was a case study in post-debridement diabetes patients with wound care using a moist NaCl 0.9% dressing and adding the topical drug octenidine

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38

Rodin, A. V. "Selection of local antiseptic for treatment and prevention of wound infection." Нospital-replacing technologies:Ambulatory surgery, no. 3-4 (November 16, 2019): 47–57. http://dx.doi.org/10.21518/1995-1477-2019-3-4-47-56.

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The advantages and disadvantages of modern antiseptics for local treatment and prevention of wound infections are considered. On the basis of data of comparative clinical studies the advantages of topical drugs based on octenidine dihydrochloride in combination with phenoxyethanol are presented. The advantages of octenidine dihydrochloride/ phenoxyethanol as a local antiseptic for treatment and prevention of wound infections in case of wound defects, burns are described.

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39

B., SURENDER REDDY, BUCHI REDDY R., V. P. CHANDRA MOULI G., and D. REDDY Y. "Synthesis of New 1-Aryl-2H-benzimidazolo[2, 1-e] imidazoles." Journal of Indian Chemical Society Vol. 65, Dec 1988 (1988): 853–54. https://doi.org/10.5281/zenodo.6090216.

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Department of Chemistry, Regional Engineering College, Warangal-506 004. <em>Manuscript received 19 February 1988, accepted 1 September 1988</em> The condensation of <em>o</em>-phenylenediamine with glycine in acid medium gave 2-aminomethylbenzimidazole dihydrochloride. The reaction or 2-aminomethylbenzimidazole dihydrochloride with the aromatic aldehydes Ia alkaline medium afforded fused benzimidazolo[2,1- <em>e</em>] imidazole derivatives. They were screened for antimicrobial activity.  

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40

Dehghanpour, Saeed, Amir H. Mahmoudkhani, and Vratislav Langer. "Redetermination of piperazine dihydrochloride monohydrate." Acta Crystallographica Section E Structure Reports Online 57, no. 7 (2001): o610—o611. http://dx.doi.org/10.1107/s1600536801009771.

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41

Ghose, S., and J. K. Dattagupta. "Struture of sulfisomidine dihydrochloride dihydrate." Acta Crystallographica Section C Crystal Structure Communications 42, no. 11 (1986): 1563–66. http://dx.doi.org/10.1107/s0108270186091461.

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Brisson, J., and A. L. Beauchamp. "Structure of 1,7-heptanediamine dihydrochloride." Acta Crystallographica Section C Crystal Structure Communications 44, no. 6 (1988): 1152–53. http://dx.doi.org/10.1107/s0108270188001167.

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Pflum, Derek A., Dhileepkumar Krishnamurthy, Zhengxu Han, Stephen A. Wald, and Chris H. Senanayake. "Asymmetric synthesis of cetirizine dihydrochloride." Tetrahedron Letters 43, no. 6 (2002): 923–26. http://dx.doi.org/10.1016/s0040-4039(01)02294-8.

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Vilchiz, V. H., R. E. Norman, and S. C. Chang. "L-Histidine Methyl Ester Dihydrochloride." Acta Crystallographica Section C Crystal Structure Communications 52, no. 3 (1996): 696–98. http://dx.doi.org/10.1107/s0108270195013308.

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Mistry, Vaishali, and Rohan Mishra. "SIMULTANEOUS ESTIMATION, VALIDATION, AND FORCED DEGRADATION STUDIES OF BETAHISTINE DIHYDROCHLORIDE AND DOMPERIDONE IN A PHARMACEUTICAL DOSAGE FORM USING RP-HPLC METHOD." Asian Journal of Pharmaceutical and Clinical Research 11, no. 10 (2018): 125. http://dx.doi.org/10.22159/ajpcr.2018.v11i10.26132.

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Objective: This study describes the stability-indicating reverse-phase high-performance liquid chromatography (RP-HPLC) method for simultaneous estimation of betahistine dihydrochloride and domperidone in pharmaceutical dosage forms.Methods: The proposed RP-HPLC method was developed using Shimadzu Prominence-i LC-2030 HPLC system equipped with UV detector and chromatographic operation was carried on Shim-pack C18 (250 mm×4.6 mm, 5 μ) column at a flow rate of 1 ml/min and the run time was 10 min. The mobile phase consisted of methanol and water in the ratio of 80:20% v/v and eluents were scanne

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Bebawy, Lories I., Mohammed F. El Tarras, and Samah A. El Sabour. "Determination of Trimetazidine Dihydrochloride in the Presence of Its Acid-Induced Degradation Products." Journal of AOAC INTERNATIONAL 87, no. 4 (2004): 827–33. http://dx.doi.org/10.1093/jaoac/87.4.827.

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Abstract Three methods are presented for the determination of trimetazidine dihydrochloride in the presence of its acid-induced degradation products. The first method was based on measurement of first-derivative D1 value of trimetazidine dihydrochloride at 282 nm over a concentration range of 8.00–56.00 μg/mL with mean percentage accuracy of 99.80 ± 1.17. The second method was based on first derivative of the ratio spectra DD1 at 282 nm over the same concentration range with the percentage accuracy of 99.14 ± 0.68. The third method was based on separation of trimetazidine dihydrochloride from

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Resende Nassur, Rita de Cássia Mirela, Giuliano Elias Pereira, Maria Beatriz Abreu Glória, and Luiz Carlos Oliveira Lima. "Rootstock influencing the quality and biogenic amines content on Syrah tropical wines." Comunicata Scientiae 8, no. 2 (2018): 202–8. http://dx.doi.org/10.14295/cs.v8i2.2562.

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The São Francisco Valley, in Brazil, is a region with harvest of grapes more than once a year due to the peculiar climate condition, being important to evaluate new agronomic variables for the vines and elucidade its influence on wine quality and nutritional compounds. Syrah vines grafted on different rootstocks (IAC-313 and Paulsen 1103) were cultivated in semi-arid conditions in Petrolina, PE, Brazil, and the quality of the wine was evaluated for color, sugars, acidity, phenolic compounds, antioxidant activity and the presence and contents of eight biogenic amines by HPLC (putrescine (PUT) d

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Sullivan, DW, RC Peterson, CV Mujer, and SC Gad. "A 7-day intravenous toxicity study and neurotoxicity assessment of pyridorin in Sprague-Dawley rats." Human & Experimental Toxicology 36, no. 7 (2016): 718–26. http://dx.doi.org/10.1177/0960327116661023.

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Pyridorin®, a naturally occurring metabolite of vitamin B6 that inhibits and scavenges reactive oxygen species, is being developed as a potential therapeutic for acute kidney injury. An investigational new drug application (IND) was opened for Pyridorin in support of its ongoing oral drug clinical development program. Currently, a Pyridorin intravenous (IV) formulation is being developed for use in surgical patients. To support the IND for Pyridorin, a full battery of nonclinical Good Laboratory Practice compliant studies was performed with no neurological or behavioral signs of toxicity seen

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LADUTSKA, A. I., M. BORISEVITCH, V. NIKALAICHUK, et al. "PRODACTION AND CHARACTERIZATION COMPLEXES FORMED BY OCTENIDINE DIHYDROCHLORIDE AND PECTIN." Микробные биотехнологии: фундаментальные и прикладные аспекты 13 (October 21, 2021): 295–307. http://dx.doi.org/10.47612/2226-3136-2021-13-295-307.

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Complexes of antiseptic octenidine dihydrochloride with biopolymer pectin were derived. The efficiency of octenidine integretion and its ratio as the component were evaluated. The electrostatic type of complexing was confirmed by dynamic light scattering and IR spectroscopy. In vitro experiments revealed antibacterial effect of complexes of octenidine dihydrochloride and pectin polysaccharide on test culture Bacillus sp. BIM B-210, whereas growth inhibition of bacteria Staphylococcus sp. BIM B-798G, Pseudomonas aeruginosa BIM B-153, Escherichia coli BIM B-378 was not observed.

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Ghule, Sneha S., Ashpak M. Tamboli, and Snehal D. Patil. "Analytical Method Development and Validation of Rp-Hplc Method for Simultaneous Estimation of Pyridoxamine Dihydrochloride and Acetylcysteine in Tablet Dosage Form." Journal of University of Shanghai for Science and Technology 23, no. 06 (2021): 992–1000. http://dx.doi.org/10.51201/jusst/21/05377.

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A reverse-phase high-performance liquid chromatography (RP-HPLC) method for the simultaneous estimation of Pyridoxamine dihydrochloride and Acetylcysteine in the marketed formulation is developed. Chromatography carried out at 30oc temperature on Agilent Zorbax Bonus-RP (250 x 4.6 mm, 5 µ) coloum. Coloum using a mobile phase 0.1% trifluroacetic acid in water: acetonitrile (80:20v/v) with flow rate 1ml/min (DAD scan at 210nm). Validation parameters such as system suitability, linearity, precision, accuracy are considered as reported International Conference on Harmonization guidelines. The rete

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