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Journal articles on the topic 'Dihydrofurane derivatives'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 February 2022

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1

Oremus, Vladimír, Lubor Fišera, and Ladislav Štibrányi. "Preparation and photochemistry of 3-cyanosubstituted condensed isoxazolines containing an oxygen atom." Collection of Czechoslovak Chemical Communications 52, no. 7 (1987): 1773–79. http://dx.doi.org/10.1135/cccc19871773.

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The 1,3-dipolar cycloaddition of cyanonitrile oxide to 2,3- and 2,5-dihydrofurane, 7-oxabicyclo[2,2,1]-2-heptene and derivatives of 1,3-dioxep-5-ene is described. The condensed isoxazolines Ia, IIIa, Va, Vc, Vd thus prepared are rearranged on irradiation into cyanosubstituted heterocyclic enaminoaldehydes IIa, IVa, VIa, VIc. The quantum yields of the photorearrangement of cyanoderivatives are higher than those of the phenyl derivatives, being within the limits from 0·068 to 0·19. The reaction of II with hydrazine gives the derivative IX of oxazino[4,5-d]pyridazine.

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2

Reissig, Hans-Ulrich, and Reinhold Zimmer. "Cyclizations of Alkoxyallenes: Mechanisms, Intermediates, Products – A Personal Account on Solved and Unsolved Problems with Unique Allene Building Blocks." Synthesis 49, no. 15 (2017): 3291–302. http://dx.doi.org/10.1055/s-0036-1588846.

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The additions of lithiated alkoxyallenes to electrophiles, such as carbonyl compounds, thioketones, imines, and nitrones, provide the expected primary addition products. These alkoxyallene intermediates undergo ring-closure reactions under quite different conditions. Whereas allenyl hydroxylamine derivatives spontaneously cyclize to 1,2-oxazine derivatives, the related allenyl amines, thiols, and alcohols require, with distinct exceptions, promotion by acids, base, silver(I), or gold(I). The different mechanisms of these processes are discussed in this account. The serendipitous discovery of a

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3

Buchta, Vladimír, Milan Pour, Petra Kubanová, et al. "In Vitro Activities of 3-(Halogenated Phenyl)-5-Acyloxymethyl- 2,5-Dihydrofuran-2-ones against Common and Emerging Yeasts and Molds." Antimicrobial Agents and Chemotherapy 48, no. 3 (2004): 873–78. http://dx.doi.org/10.1128/aac.48.3.873-878.2004.

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ABSTRACT Three 3-(halogenated phenyl)-5-acyloxymethyl-2,5-dihydrofuran-2-ones were evaluated for activity against 191 strains of common and emerging yeasts and Aspergillus species by the broth microdilution test performed according to NCCLS guidelines. The furanone derivatives displayed broad-spectrum in vitro activity against potentially pathogenic yeasts and molds, especially Aspergillus spp. (MIC ≤ 2.0 μg/ml) and fluconazole-resistant yeast isolates, including Candida glabrata and Saccharomyces cerevisiae. The 4-bromophenyl derivative was the most effective derivative against the majority o

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4

Siliveri, Sravanthi, Harinadha Babu Vamaraju, and Shivaraj. "Synthesis and Biological Evaluation of Furo[3,2-c]pyrazole-5-carbimidates." Asian Journal of Chemistry 31, no. 10 (2019): 2389–93. http://dx.doi.org/10.14233/ajchem.2019.21971.

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In the present work, novel pyrazole fused dihydrofurans synthesized via a chronological addition of N-chloro succinimide and base piperidine to pyrano[3,2-c]pyrazole carbonitrile derivatives in methanol medium. Oxidative difunctionalization was done with the reagent N-chloro succinimide by the addition of both chlorine and alkoxy groups crosswise the chromene double bond. The addition of base results in the construction of dihydrofuran derivatives by ring contraction. The structures of newly synthesized compounds were characterized on the basis of physical and spectral data. Synthesized compou

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5

Lu, Shan, Siegfried Draeger, Barbara Schulz, et al. "Bioactive Aromatic Derivatives from Endophytic Fungus, Cytospora sp." Natural Product Communications 6, no. 5 (2011): 1934578X1100600. http://dx.doi.org/10.1177/1934578x1100600518.

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Two new benzyl γ-butyrolactone analogues, ( R)-5-(( S)-hydroxy(phenyl)-methyl)dihydrofuran-2(3H)-one (1) and its 6-acetate (2), and a new naphthalenone derivative (8), together with eight additional known aromatic derivatives, ( S)-5-(( S)-hydroxy(phenyl)-methyl)dihydrofuran-2(3H)-one (3), ( S)-5-benzyl-dihydrofuran-2(3H)-one (4), 5-phenyl-4-oxopentanoic acid (5), γ-oxo-benzenepentanoic acid methyl ester (6), 3-(2,5-dihydro-4-hydroxy-5-oxo-3-phenyl-2-furyl)propionic acid (7), (3 R)-5-methylmellein (9), integracins A (10) and B (11) were isolated from Cytospora sp., an endophytic fungus isolate

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6

Fišera, Lubor, Igor Goljer, and Libuše Jarošková. "Reaction of tetrahydrofuroisoxazoles with molybdenum hexacarbonyl. A new route to preparation of 3-substituted tetrahydro- and dihydrofuran derivatives." Collection of Czechoslovak Chemical Communications 53, no. 8 (1988): 1753–60. http://dx.doi.org/10.1135/cccc19881753.

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3-(4-X-Phenyl)-3a,4,6,6a-tetrahydrofuro[3,4-d]isoxazoles Ia-If (X = H, CH3, CH3O, Cl, F, C6H5) react with molybdenum hexacarbonyl to give not only the expected cis-3-aroyl-4-hydroxytetrahydrofuran III, but also its trans isomer IV and 3-aroyl-2,5-dihydrofuran II. This paper concerns a new preparation of 3-aroyl-2,5-dihydrofuran derivatives starting from 2,5-dihydrofuran via 1,3-dipolar cycloaddition of nitrile oxides, cleavage with molybdenum hexacarbonyl and dehydratation with p-toluenesulfonic acid. The structure of cis-(III) and trans-(IV) derivatives was deduced from both the γ-effect in t

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7

V, Vijay, Manjusha V. Karkhelikar, B. Sridhar, Nedaossadat Mirzadeh, Suresh Bhargava, and Pravin R. Likhar. "Electronically modified amine substituted alkynols for regio-selective synthesis of dihydrofuran derivatives." Organic & Biomolecular Chemistry 14, no. 1 (2016): 288–95. http://dx.doi.org/10.1039/c5ob02033f.

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8

Geibel, Irina, Marc Schmidtmann, and Jens Christoffers. "Cerium-catalyzed, oxidative synthesis of annulated, tetrasubstituted dihydrofuran-derivatives." Organic & Biomolecular Chemistry 15, no. 37 (2017): 7824–29. http://dx.doi.org/10.1039/c7ob01904a.

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9

Shi, Taoda, Shenghan Teng, Yajie Wei, Xin Guo та Wenhao Hu. "Synthesis of spiro[2,3-dihydrofuran-3,3′-oxindole] derivatives via a multi-component cascade reaction of α-diazo esters, water, isatins and malononitrile/ethyl cyanoacetate". Green Chemistry 21, № 18 (2019): 4936–40. http://dx.doi.org/10.1039/c9gc01751h.

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10

Chen, Zi-cong, Lang Tong, Zhi-bo Du та ін. "Annulation of β-naphthols and 4-hydroxycoumarins with vinylsulfonium salts: synthesis of dihydrofuran derivatives". Organic & Biomolecular Chemistry 16, № 15 (2018): 2634–38. http://dx.doi.org/10.1039/c8ob00293b.

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11

Sun, Zhen, Zheng Li, and Wei-Wei Liao. "An organocatalytic hydroalkoxylation/Claisen rearrangement/Michael addition tandem sequence: divergent synthesis of multi-substituted 2,3-dihydrofurans and 2,3-dihydropyrroles from cyanohydrins." Green Chemistry 21, no. 7 (2019): 1614–18. http://dx.doi.org/10.1039/c8gc03978j.

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12

SARI, Sait, and Mehmet YILMAZ. "Synthesis and characterization of piperazine-substituted dihydrofuran derivatives viaMn(OAc)3 mediated radical cyclizations." TURKISH JOURNAL OF CHEMISTRY 44, no. 5 (2020): 1303–13. http://dx.doi.org/10.3906/kim-2003-23.

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The aim of this study is to synthesize novel piperazine-containing dihydrofuran compounds (3a-n)from radical additions and cyclizations of diacyl and alkyl-acyl piperazine derivatives (1a-h) with 1,3-dicarbonyl compounds (2a-c) mediated by Mn(OAc)3 for the first time. From the reactions of 1a-c with dimedone (2a);1a, 1c, and 1d with acetylacetone (2b); and 1a with ethylacetoacetate(2c) ,the dihydrofuran-piperazine compounds 3a-c, 3d-f, and 3g were obtained in medium to high yields (31%–81%), respectively. In addition, dihydrofuran-piperazine compounds 3h-j and 3k-n were prepared at low to medi

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13

Tangella, Yellaiah, Kesari Lakshmi Manasa, V. Laxma Nayak, et al. "An efficient one-pot approach for the regio- and diastereoselective synthesis of trans-dihydrofuran derivatives: cytotoxicity and DNA-binding studies." Organic & Biomolecular Chemistry 15, no. 32 (2017): 6837–53. http://dx.doi.org/10.1039/c7ob01456b.

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A facile one-pot, three component strategy has been developed for the construction oftrans-2,3-dihydrofuran derivatives. All the synthesized compounds have been evaluated for their cytotoxic activity.

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14

Brown, RFC, and RP Mcgeary. "A Pyrolytic Preparation of (S)-2-(t-Butyl-Dimethyl-silyloxymethyl)-2,3-dihydrofuran." Australian Journal of Chemistry 46, no. 8 (1993): 1321. http://dx.doi.org/10.1071/ch9931321.

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15

Sunil, Komalla, Yadagiri Thummala, Purnachandar Dalovai, Sridhar Balasubramanian, and Galla V. Karunakar. "A gold-catalyzed facile intramolecular rearrangement and cyclization sequence for synthesis of 2,5-dihydrofurans." Organic & Biomolecular Chemistry 17, no. 24 (2019): 6015–24. http://dx.doi.org/10.1039/c9ob00756c.

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An efficient gold-catalyzed intramolecular rearrangement and cyclization protocol was developed for synthesis of 2,5-dihydrofuran derivatives via formation of a new C–C and C–O bond with a quaternary centre.

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16

Bai, Xiaohui, Leiyang Lv, and Zhiping Li. "Copper-catalyzed tandem trifluoromethylation–cyclization of olefinic carbonyls: synthesis of trifluoromethylated 2,3-dihydrofurans and 3,4-dihydropyrans." Organic Chemistry Frontiers 3, no. 7 (2016): 804–8. http://dx.doi.org/10.1039/c6qo00137h.

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A copper-catalyzed trifluoromethylation–cyclization of olefinic carbonyls was developed. With this method, a variety of 2,3-dihydrofuran and 3,4-dihydropyran derivatives containing a CF<sub>3</sub> group were selectively obtained in moderate to good yields.

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17

Wu, Xiaoyan, Junjie Fan, Xin Huang, and Shengming Ma. "Rh-Catalyzed oxidative homo-coupling cyclization of 2,3-allenols to conjugated furylenones." Organic Chemistry Frontiers 8, no. 16 (2021): 4432–37. http://dx.doi.org/10.1039/d1qo00599e.

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An unexpected rhodium-catalyzed highly regio- and stereo-selective bimolecular nucleophilic oxyrhodation/insertion/1,4-Rh migration/β-H elimination reaction of 2,3-allenols affording (2,5-dihydrofuran-3-yl)but-2(E)-en-1-one derivatives is reported.

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18

Zagidullin, Almaz, Daut Islamov, Elena Oshchepkova, Peter Lonnecke, and Vasili Miluykov. "Crystal structure of 3-(triphenylphosphoranylidene)-2,5-dihydrofuran-2,5-dione tetrahydrofuran monosolvate." Acta Crystallographica Section E Crystallographic Communications 74, no. 9 (2018): 1336–38. http://dx.doi.org/10.1107/s2056989018011775.

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The title pseudo-polymorph of 3-(triphenylphosphoranylidene)-2,5-dihydrofuran-2,5-dione crystallizes with a tetrahydrofuran solvent molecule, viz. C22H17O3P·C4H8O. The succinic anhydride ring is approximately planar (r.m.s. deviation = 0.032 Å). The tetrahydrofuran molecule is disordered over two orientations about a pseudo-twofold axis with refined occupancy ratio 0.718 (4):0.282 (4). In the crystal, C—H...O hydrogen bonds link molecules of the dihydrofuran-2,5-dione derivative into chains parallel to the b axis and arranged into layers stacked along [100] alternating with hydrogen-bonded tet

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19

Ma, Jun-Rui, Wen-Ming Shu, Kai-Lu Zheng, Fan Ni, Guo-Dong Yin, and An-Xin Wu. "Efficient approach to 2-hydroxy-2,3-dihydrofuran derivatives and its application for the synthesis of novel 4-(1H-pyrazol-4-yl)pyridazines." Organic & Biomolecular Chemistry 13, no. 17 (2015): 4976–80. http://dx.doi.org/10.1039/c5ob00163c.

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A highly efficient method for the synthesis of 2-hydroxy-2,3-dihydrofuran derivatives from 1,4-enediones and phenacyl pyridinium halides via a domino reaction has been developed. At the same time, we also synthesize the novel 4-(1H-pyrazol-4-yl)pyridazine skeleton.

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20

Xu, Jing, Wenbo Huang, Rongxian Bai, Yves Queneau, François Jérôme, and Yanlong Gu. "Utilization of bio-based glycolaldehyde aqueous solution in organic synthesis: application to the synthesis of 2,3-dihydrofurans." Green Chemistry 21, no. 8 (2019): 2061–69. http://dx.doi.org/10.1039/c8gc04000a.

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Bio-based glycolaldehyde aqueous solution was used as a C2 building block for the synthesis of a class of dihydrofuran derivatives with the aid of a deep eutectic solvent composed of FeCl<sub>3</sub>·6H<sub>2</sub>O and meglumine.

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21

Findik, E., A. Dingil, I. Karaman, Y. Budak, and M. Ceylan. "Synthesis of Multi-substituted 4,5-Dihydrofuran Derivatives from (S)-Limonene and 1,3-Dicarbonyl Compounds and their Biological Activities." E-Journal of Chemistry 6, s1 (2009): S53—S58. http://dx.doi.org/10.1155/2009/353268.

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Multi-substituted 4,5-dihydrofuran derivatives were regioselectively synthesized by the reaction of α-carbo radical produced from 1,3-dicarbonyl compounds by oxidation with Mn(OAc)3in Acetic acid andS-(-)-limonene. All the compounds were tested for their antibacterial and antifungal activities by the disc-diffusion technique.

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22

Yang, Han-Lin, Li-Jun Xu, Wen-Zhong Li та ін. "Base-iodine-promoted metal-catalyst-free reactions of [60]fullerene with β-keto esters for the selective formation of [60]fullerene derivatives". RSC Advances 10, № 41 (2020): 24549–54. http://dx.doi.org/10.1039/d0ra04996d.

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In this study, methanofullerenes and 2′,3′-dihydrofuran C<sub>60</sub> derivatives were selectively synthesized in high yields via the reactions of C<sub>60</sub> with β-keto esters under mild conditions by controlling the addition sequence and molar ratio of iodine and base.

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23

Sietmann, Rabea, Elke Hammer, Michael Specht, Carl E. Cerniglia, and Frieder Schauer. "Novel Ring Cleavage Products in the Biotransformation of Biphenyl by the Yeast Trichosporon mucoides." Applied and Environmental Microbiology 67, no. 9 (2001): 4158–65. http://dx.doi.org/10.1128/aem.67.9.4158-4165.2001.

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ABSTRACT The yeast Trichosporon mucoides, grown on either glucose or phenol, was able to transform biphenyl into a variety of mono-, di-, and trihydroxylated derivatives hydroxylated on one or both aromatic rings. While some of these products accumulated in the supernatant as dead end products, the ortho-substituted dihydroxylated biphenyls were substrates for further oxidation and ring fission. These ring fission products were identified by high-performance liquid chromatography, gas chromatography-mass spectrometry, and nuclear magnetic resonance analyses as phenyl derivatives of hydroxymuco

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24

Alekseeva, Kseniia A., Pavel V. Raspertov, Sevim Türktekin Çelikesir, Mehmet Akkurt, Flavien A. A. Toze, and Elena A. Sorokina. "Crystal structure and Hirshfeld surface analysis of dimethyl (1R*,3aS*,3a1 R*,6aS*,9R*,9aS*)-3a1,5,6,9a-tetrahydro-1H,4H,9H-1,3a:6a,9-diepoxyphenalene-2,3-dicarboxylate." Acta Crystallographica Section E Crystallographic Communications 75, no. 4 (2019): 460–64. http://dx.doi.org/10.1107/s2056989019003499.

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The title diepoxyphenalene derivative, C17H18O6, comprises a fused cyclic system containing four five-membered rings (two dihydrofuran and two tetrahydrofuran) and one six-membered ring (cyclohexane). The five-membered dihydrofuran and tetrahydrofuran rings adopt envelope conformations, and the six-membered cyclohexane ring adopts a distorted chair conformation. Two methyl carboxylate groups occupy adjacent positions (2- and 3-) on a tetrahydrofuran ring. In the crystal, two pairs of C—H...O hydrogen bonds link the molecules to form inversion dimers, enclosing two R 2 2(6) ring motifs, that st

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25

Oremus, Vladimír, Lubor Fišera, and Hans-Joachim Timpe. "Preparation and photochemistry of 3-methoxycarbonyl substituted condensed isoxazolines." Collection of Czechoslovak Chemical Communications 52, no. 12 (1987): 2953–60. http://dx.doi.org/10.1135/cccc19872953.

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The 1,3-dipolar cycloaddition of methoxy- and ethoxycarbonylnitriloxide to 2,3- and 2,5-dihydrofuran, 2,3-dihydropyrane, 7-oxabicyclo[2,2,1]-2-heptene, and 1,3-dioxep-5-ene derivatives is described. The condensed isoxazolines Ia, IIIa, Va, Vb are rearranged on irradiation to give the methoxycarbonyl substituted enaminoaldehydes IIa, IVa, VIa, VIb, respectively. The photolysis of VIIc, VIIIa, VIIIc is connected with destruction. The quantum yields of the photorearrangement are higher than those of the phenyl substituted derivatives but lower than those of the corresponding cyano derivatives. Th

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26

Chen, Guodong, Weiguo Cao, Jie Chen, and Rongqing Chen. "High Stereoselective Synthesis of trans‐2,3‐Dihydrofuran Derivatives." Synthetic Communications 34, no. 20 (2004): 3793–99. http://dx.doi.org/10.1081/scc-200032510.

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27

Yonezumi, Motomasa, Shokyoku Kanaoka, and Sadahito Aoshima. "Living cationic polymerization of dihydrofuran and its derivatives." Journal of Polymer Science Part A: Polymer Chemistry 46, no. 13 (2008): 4495–504. http://dx.doi.org/10.1002/pola.22785.

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28

Güngör, Füsun Şeyma, Olcay Anaç, and Özkan Sezer. "Synthesis of the Naphthalenone, Dihydroquinoline, and Dihydrofuran Derivatives." Helvetica Chimica Acta 94, no. 6 (2011): 1115–29. http://dx.doi.org/10.1002/hlca.201000386.

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29

ITOKAWA, HIDEJI, HAJIME MATSUMOTO, TOSHIYUKI OSHIMA, and SUSUMU MIHASHI. "Photocycloaddition of Benzaldehyde to 2, 3-Dihydrofuran Derivatives." YAKUGAKU ZASSHI 107, no. 10 (1987): 767–73. http://dx.doi.org/10.1248/yakushi1947.107.10_767.

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30

Len, Christophe, M. Rodriguez-Fernandez, Sophie Vuong, and Brigitte Renoux. "3-Vinyl-2,5-dihydrofuran Derivatives via Enyne Metathesis." Synlett 2007, no. 11 (2007): 1703–6. http://dx.doi.org/10.1055/s-2007-984503.

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31

Besenyei, Gábor, András Neszmélyi, Sándor Holly, László I. Simándi, and László Párkányi. "A relationship between the catalytic carbonylation of (N-arenesulfonyl)imides and iodonium ylides." Canadian Journal of Chemistry 79, no. 5-6 (2001): 649–54. http://dx.doi.org/10.1139/v01-074.

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Reactivities of various sulfonamide derivatives of general formula ArSO2N=XPhn (X = I; n = 1; X = S, Se, n = 2; X = P, As, n = 3) in catalytic carbonylations have been explained by structural properties of the substrates. Based on crystallographic data reported in the literature, it has been concluded that the two-step catalytic oxidative carbonylation of sulfonylimides proceeds only when the N=X double bond is strongly polarized. The structural requirement observed within the sulfonamide derivatives has been found to be applicable for iodonium ylides. Catalytic carbonylation of the phenyliodo

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32

Cao, Ziping, Rumeng Zhang, Xin Meng та ін. "Sc(OTf)3-catalyzed cyclization of α-allylated 1,3-dicarbonyls: an efficient access to 2,2-disubstituted 2,3-dihydrofuran derivatives". RSC Advances 6, № 78 (2016): 74582–85. http://dx.doi.org/10.1039/c6ra14051c.

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33

Fujita, Takeshi, Ryutaro Morioka, Tomohiro Arita, and Junji Ichikawa. "sp3 carbon–fluorine bond activation in 2,2-difluorohomoallylic alcohols via nucleophilic 5-endo-trig cyclisation: synthesis of 3-fluorinated furan derivatives." Chemical Communications 54, no. 92 (2018): 12938–41. http://dx.doi.org/10.1039/c8cc04643c.

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34

Tokmajyan, G. G., L. V. Karapetyan, R. V. Paronikyan, and H. M. Stepanyan. "SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NEW DERIVATIVES OF 2-OXO-2,5-DIHYDROFURANS CONTAINING AN OXOTHIAZOLIDINYLIDENE RING." Proceedings of the YSU B: Chemical and Biological Sciences 54, no. 1 (251) (2020): 12–16. http://dx.doi.org/10.46991/pysu:b/2020.54.1.012.

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ring were successfully synthesized based on thiosemicarbazones of 3-acetyl-2-oxo-2,5-dihydrofurans. The synthesized compounds exhibited moderate to defined antibacterial activities against Gram-positive (Staphylococcus aureus 209P and 1) and Gram-negative (Shigella Flexneri 6858, Esherichia coli 0–55) bacteria compared to furazolidone.

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35

Özgür, Mehtap, Mehmet Yılmaz, Hiroshi Nishino, et al. "Efficient syntheses and antimicrobial activities of new thiophene containing pyranone and quinolinone derivatives using manganese(iii) acetate: the effect of thiophene on ring closure–opening reactions." New Journal of Chemistry 43, no. 15 (2019): 5737–51. http://dx.doi.org/10.1039/c9nj00054b.

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36

Ghochikyan, Tariel V., Melanya A. Samvelyan, Vilik S. Harutyunyan, Edgar V. Harutyunyan, Andranik Petrosyan, and Peter Langer. "Synthesis of aminomethyl derivatives of 5-substituted-3-(prop-2-ynyl)dihydrofuran-2(3H)-ones." Zeitschrift für Naturforschung B 71, no. 3 (2016): 267–71. http://dx.doi.org/10.1515/znb-2015-0144.

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AbstractAn easy approach for the synthesis of various 5-substituted-3-(prop-2-ynyl)dihydrofuran-2(3H)-ones is described. As a method of choice, Mannich aminomethylation of terminal alkynes is adopted. The reaction works well with acyclic and cyclic secondary amines and provides the desired products, with good to very good yields.

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37

Narasegowda, R. N., H. S. Yathirajan, D. E. Lynch, T. Narasimhamurthy, and R. S. Rathore. "1-Isopropyl-6,6,8a-trimethyl-1,3a,5,6,7,8a-hexahydro-3H-1-benzofuro[2,3-b]pyrrole-2,4-dione." Acta Crystallographica Section E Structure Reports Online 62, no. 4 (2006): o1328—o1329. http://dx.doi.org/10.1107/s1600536806006180.

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The crystal structure of the title benzofuran derivative, C16H23NO3, has been elucidated. The tricyclic core, i.e. the tetrahydrobenzo–dihydrofuro–pyrrolidine ring system, is non-planar owing to the folding of the five-membered rings at their cis junction. The cyclohexene ring assumes a half-chair conformation, while the dihydrofuran and pyrrolidine rings each adopt an envelope conformation. Intramolecular C—H...O hydrogen bonds form S(6) closed patterns.

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38

Lolya, D., Ya Freimanis, M. Gavar, Yu Popelis, I. Turovskii, and V. Belikov. "Protolytic cleavage of derivatives of 2,5-dimethoxy-2,5-dihydrofuran." Chemistry of Heterocyclic Compounds 33, no. 2 (1997): 164–70. http://dx.doi.org/10.1007/bf02256757.

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39

Avetisyan, A. A., L. V. Karapetyan, R. V. Paronikyan, and H. M. Stepanyan. "Synthesis and antibacterial activity of new 2.5-dihydrofuran derivatives." Pharmaceutical Chemistry Journal 45, no. 3 (2011): 156–58. http://dx.doi.org/10.1007/s11094-011-0582-2.

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40

Miksch, April M., Annalena Riffelt, Ricardo Oliveira, Johannes Kästner, and Germán Molpeceres. "Hydrogenation of small aromatic heterocycles at low temperatures." Monthly Notices of the Royal Astronomical Society 505, no. 3 (2021): 3157–64. http://dx.doi.org/10.1093/mnras/stab1514.

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ABSTRACT The recent wave of detections of interstellar aromatic molecules has sparked interest in the chemical behaviour of aromatic molecules under astrophysical conditions. In most cases, these detections have been made through chemically related molecules, called proxies, that implicitly indicate the presence of a parent molecule. In this study, we present the results of the theoretical evaluation of the hydrogenation reactions of different aromatic molecules (benzene, pyridine, pyrrole, furan, thiophene, silabenzene, and phosphorine). The viability of these reactions allows us to evaluate

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41

Fusi, Stefania, Donato Donati, and Fabio Ponticelli. "Reaction of Arylnitroso Derivatives: Synthesis of Arylimino 2,5-Dihydrofuran and Arylamino Fulvenes Derivatives." International Journal of Organic Chemistry 06, no. 02 (2016): 147–55. http://dx.doi.org/10.4236/ijoc.2016.62016.

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LOLYA, D., YA FREIMANIS, M. GAVAR, YU POPELIS, I. TUROVSKII, and V. BELIKOV. "ChemInform Abstract: Protolytic Cleavage of 2,5-Dimethoxy-2,5-dihydrofuran Derivatives." ChemInform 28, no. 27 (2010): no. http://dx.doi.org/10.1002/chin.199727044.

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Yao, Changsheng, Ying Wang, Tuanjie Li, Chenxia Yu, Liang Li, and Chao Wang. "A pseudo multi-component electrochemical synthesis of spiro dihydrofuran derivatives." Tetrahedron 69, no. 49 (2013): 10593–97. http://dx.doi.org/10.1016/j.tet.2013.10.056.

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44

Azizian, Javad, Ali Reza Karimi, Ebrahim Soleimani, Ali A. Mohammadi, and Mohammad R. Mohammadizadeh. "Highly functionalized dihydrofuran derivatives: Synthesis by diastereoselective intramolecular Wittig reaction." Heteroatom Chemistry 17, no. 4 (2006): 277–79. http://dx.doi.org/10.1002/hc.20202.

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Rompes, J. A., S. Hoff, P. P. Montijn, L. Brandsma, and J. F. Arens. "Derivatives of furan and 2,5-dihydrofuran from cumulenic carbinol ethers." Recueil des Travaux Chimiques des Pays-Bas 88, no. 12 (2010): 1445–50. http://dx.doi.org/10.1002/recl.19690881209.

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Shang, Yongjia, Kai Ju, Xinwei He, et al. "Copper-Catalyzed Multicomponent Reaction: Synthesis of 4-Arylsulfonylimino-4,5-dihydrofuran Derivatives." Journal of Organic Chemistry 75, no. 16 (2010): 5743–45. http://dx.doi.org/10.1021/jo1010075.

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Cao, Weiguo, Guodong Chen, Jie Chen, and Rongqing Chen. "Simple Approach to the High Stereoselective Synthesis oftrans‐2,3‐Dihydrofuran Derivatives." Synthetic Communications 35, no. 4 (2005): 527–33. http://dx.doi.org/10.1081/scc-200049776.

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Scheide, Marcos R., Alex R. Schneider, Guilherme A. M. Jardim, et al. "Electrochemical synthesis of selenyl-dihydrofurans via anodic selenofunctionalization of allyl-naphthol/phenol derivatives and their anti-Alzheimer activity." Organic & Biomolecular Chemistry 18, no. 26 (2020): 4916–21. http://dx.doi.org/10.1039/d0ob00629g.

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Kuneš, Jiří, Vojtěch Balšánek, Milan Pour, and Vladimír Buchta. "Synthesis and Antifungal Activity Evaluation of 3-Hetaryl-2,5-dihydrofuran-2-ones. An Unusual Fragmentation of the Oxazole Ring via 2,3-Selenoxide Shift." Collection of Czechoslovak Chemical Communications 66, no. 12 (2001): 1809–30. http://dx.doi.org/10.1135/cccc20011809.

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In continuing the studies on the synthesis and evaluation of antifungal activity of the analogues of (-)incrustoporine, the replacement of the phenyl moiety at C3 of the furanone ring with a hetaryl substituent was considered. Thus, a series of 5-alkyl-3-hetaryl-2,5-dihydrofuran-2-ones with the thienyl, furyl and thiazolyl moieties attached to C3 was synthesized, and the compounds subjected to antifungal activity screening. In the preparation of compounds containing the oxazolyl fragment, the [2,3]-sigmatropic rearrangement led to the fragmentation of the oxazole ring, resulting in the formati

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Avetisyan, A. A., A. G. Alvandzhyan, and K. S. Avetisyan. "Synthesis of new unsaturated derivatives of functionally substituted 2-imino-2,5-dihydrofurans." Russian Journal of Organic Chemistry 47, no. 3 (2011): 433–36. http://dx.doi.org/10.1134/s1070428011030183.

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