Academic literature on the topic 'Dihydroisoquinolines'

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Journal articles on the topic "Dihydroisoquinolines"

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Puerto Galvis, Carlos, Mario Macías, and Vladimir Kouznetsov. "Unexpected PF6 Anion Metathesis during the Bischler–Napieralski Reaction: Synthesis of 3,4-Dihydroisoquinoline Hexafluorophosphates and Their Tetrahydroisoquinoline Related Alkaloids." Synthesis 51, no. 09 (2019): 1949–60. http://dx.doi.org/10.1055/s-0037-1610684.

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A series of N-phenethylcinnamamides were subjected to the Bischler–Napieralski reaction to furnish diverse 1-styryl-3,4-dihydroisoquinolines. We noticed that the desired products were unstable when the reaction was performed under conventional solvent conditions. However, when [bmim]PF6 was used as the reaction media, the nature of the Bischler–Napieralski reaction promoted an unusual in situ ionic interchange between this ionic liquid and the dihydroisoquinoline core that led to the stabilization of the desired 1-styryl-3,4-dihydroisoquinolines, allowing their isolation as hexafluorophosphate
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Mwansa, Joseph M., Matthew J. Stirling, and Michael I. Page. "Changing the kinetic order of enantiomer formation and distinguishing between iminium ion and imine as the reactive species in the asymmetric transfer hydrogenation of substituted imines using a cyclopentadienyl iridium (III) complex." Pure and Applied Chemistry 92, no. 1 (2020): 107–21. http://dx.doi.org/10.1515/pac-2019-0222.

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AbstractThe iridium (III) complex of pentamethylcyclopentadiene and (S,S) or (R,R)-1,2-diphenyl-N′-tosylethane-1,2-diamine is an effective catalyst for the asymmetric transfer hydrogenation of imines under acidic conditions. However, the enantiomeric excess (ee) of the product amines from the reduction of 1-methyl-3,4-dihydroisoquinolines in either acetonitrile or dichloromethane, decreases exponentially. The dominant cause of the enantioselectivity is the difference in kinetic order of the formation of the two enantiomers with the S-enantiomer being formed in a first-order process whereas tha
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Kmieciak, Anna, Marta Ćwiklińska, Karolina Jeżak, Afef Shili, and Marek P. Krzemiński. "Searching for New Biologically Active Compounds Derived from Isoquinoline Alkaloids." Chemistry Proceedings 3, no. 1 (2020): 97. http://dx.doi.org/10.3390/ecsoc-24-08417.

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Many isoquinoline alkaloids are biologically active compounds and successfully used as pharmaceuticals. Compounds belonging to the isoquinolines and tetrahydroisoquinolines (TIQs) can be used as anesthetics, antihypertensive drugs, antiviral agents, and vasodilators. In the presented studies, the search for new compounds and synthesis of tetrahydroisoquinoline alkaloid derivatives was undertaken. Several dihydroisoquinolines were synthesized by Bishler–Napieralski reaction from the corresponding amides. Dihydroisoquinolines were reduced with sodium borohydride to obtain racemic tetrahydroisoqu
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Flores-Ferrándiz, Jesús, Nicholas Carter, Maria José González-Soria, et al. "Stereoselective synthesis of 1,3-disubstituted dihydroisoquinolines vial-phenylalanine-derived dihydroisoquinoline N-oxides." Organic & Biomolecular Chemistry 16, no. 38 (2018): 6961–68. http://dx.doi.org/10.1039/c8ob02007h.

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Addition of Grignard reagents and alkenes to readily available (S)-3-(hydroxymethyl)-3,4-dihydroisoquinoline-2-oxide allow the highly stereoselective synthesis of a range of 1,3-disubstituted tetrahydroisoquinolines.
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Facchetti, Giorgio, Michael S. Christodoulou, Eleonora Binda, Marco Fusè, and Isabella Rimoldi. "Asymmetric Hydrogenation of 1-aryl substituted-3,4-Dihydroisoquinolines with Iridium Catalysts Bearing Different Phosphorus-Based Ligands." Catalysts 10, no. 8 (2020): 914. http://dx.doi.org/10.3390/catal10080914.

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Starting from the chiral 5,6,7,8-tetrahydroquinolin-8-ol core, a series of amino-phosphorus-based ligands was realized. The so-obtained amino-phosphine ligand (L1), amino-phosphinite (L2) and amino-phosphite (L3) were evaluated in iridium complexes together with the heterobiaryl diphosphines tetraMe-BITIOP (L4), Diophep (L5) and L6 and L7 ligands, characterized by mixed chirality. Their catalytic performance in the asymmetric hydrogenation (AH) of the model substrate 6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinoline 1a led us to identify Ir-L4 and Ir-L5 catalysts as the most effective. The applic
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Chen, Lei, Chuanxi Sun, Guidong Feng, et al. "Direct oxidative C–H alkynylation of N-carbamoyl tetrahydroisoquinolines and dihydroisoquinolines." Organic & Biomolecular Chemistry 16, no. 15 (2018): 2792–99. http://dx.doi.org/10.1039/c8ob00373d.

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Fathimath Salfeena, C. T., K. T. Ashitha, and B. S. Sasidhar. "BF3·Et2O mediated one-step synthesis of N-substituted-1,2-dihydropyridines, indenopyridines and 5,6-dihydroisoquinolines." Organic & Biomolecular Chemistry 14, no. 43 (2016): 10165–69. http://dx.doi.org/10.1039/c6ob02133f.

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Ramanivas, T., G. Gayatri, D. Priyanka, V. L. Nayak, K. K. Singarapu, and A. K. Srivastava. "Stereoselective synthesis of functionalized 1,2,3,4-tetrahydroisoquinolines (THIQs) via highly diastereoselective Ugi three-component reactions (U3CRs) with chiral 3,4-dihydroisoquinolines (DHIQs)." RSC Advances 5, no. 90 (2015): 73373–80. http://dx.doi.org/10.1039/c5ra11144g.

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Liu, Wangsheng, Shasha Liu, Ruiwen Jin, Hao Guo, and Jinbo Zhao. "Novel strategies for catalytic asymmetric synthesis of C1-chiral 1,2,3,4-tetrahydroisoquinolines and 3,4-dihydrotetrahydroisoquinolines." Organic Chemistry Frontiers 2, no. 3 (2015): 288–99. http://dx.doi.org/10.1039/c4qo00294f.

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Voskressensky, L. G., T. N. Borisova, M. D. Matveeva, et al. "A novel multi-component approach to the synthesis of pyrrolo[2,1-a]isoquinoline derivatives." RSC Advances 6, no. 78 (2016): 74068–71. http://dx.doi.org/10.1039/c6ra15810b.

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Dissertations / Theses on the topic "Dihydroisoquinolines"

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Ropic, Melanie. "Kinetic studies of asymmetric transfer hydrogenation of 1-Methyl-6,7-dimethoxy-3,4-dihydroisoquinoline using in-situ FTIR spectroscopy." Thesis, University of Hull, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.479148.

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Li, Deng-Hong, та 李登鴻. "Study on Addition Reaction of 3,4-Dihydroisoquinolines with γ-Hydroxy-α,β-unsaturated Phenyl Ketone at Room Temperature". Thesis, 2016. http://ndltd.ncl.edu.tw/handle/a65778.

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碩士<br>國立暨南國際大學<br>應用化學系<br>104<br>The application of asymmetric aza-Michael addition reactions by utilizing organic catalyst is one of the important synthesis methods to create a carbon-nitrogen bond. And it is useful for nature product and medicine synthesis. It has economic benefits and is environmentaly friendly in asymmetric synthesis. In this thesis, aza-Michael addition reaction’s product is 1,3-oxazolidine. 1,3-Oxazolidines are important structural moieties that exist in many biologically active compound. For example, quinocarcin and its analogue terazomine are polycyclic tetrahydroisoq
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Panayides, Jenny-Lee. "Investigations into the use of Ring Closing Metathesis to form 5-, 6-, 7- and 8-membered benzo-fused heterocylces." Thesis, 2006. http://hdl.handle.net/10539/1579.

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Student Number : 0002306V - MSc dissertation - School of Chemistry - Faculty of Science<br>The first part of the dissertation involves the use of ring closing metathesis (RCM) and ruthenium mediated isomerisation-RCM tandem reactions to form a wide range of nitrogencontaining benzo-fused heterocycles. Those synthesized include the 6-membered isoquinolines, the 7-membered benzazepines and the 8-membered benzazocines. In order to put these compounds into perspective, a review of selected naturally occurring nitrogencontaining benzo-fused heterocycles is included along with some of their
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Chiu, Yi-Pang, та 邱奕邦. "1. Synthesis of Pyromellitic Dithioimides in n-type Organic Field Effect Transistor2. Synthetic Study on aza-Michael Addition of γ-Amino-α,β-Unsaturated Ketones and 3,4-Dihydroisoquinolines". Thesis, 2017. http://ndltd.ncl.edu.tw/handle/v9e36q.

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碩士<br>國立暨南國際大學<br>應用化學系<br>105<br>This dissertation is divided into the following two parts. Part I:   The first chapter describes the synthesis of pyromellitic dithioimides, which can be used for n-type organic field effect transistor. A series of pyromellitic dithioimides were prepared from pyromellitic diimides. Then, the devices containing pyromellitic dithioimides showed good performance. We confirmed that oxygen-sulfur substitution not only enhances the electron mobility and air-stability but also improves molecular arrangement. Subsequently, we tried to synthesize dibrominated core pyro
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Huang, Sheng-Han, and 黃聖涵. "1. Total Synthesis of (+)-Antrocin 2. Study and Synthesis of Thionated Perylene Diimides for N-Channel Organic Field Effect Transistors3. Thiazo[2,3-a]tetrahydroisoquinolines from Addition Reaction of 3,4-Dihydroisoquinolines with (E)-4-Mercapto-2-butenoic Ester." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/05116601965888128991.

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博士<br>國立暨南國際大學<br>應用化學系<br>105<br>Part 1: This thesis three parts. The frist total synthesis of (+)-antrocin, which was need to clarify the absolute structure of the natural sesquiterpenoid (-)-antrocin. Special transformations in this synthetic route include highly stereoselective intramolecular Diels-Alder reaction (IMDA) of camphanate triene intermediate and highly efficient selective hydrogenation with two different catalysts. We explain the key intramolecular Diels-Alder reaction mechanism by density functional theory calculation. Overall the (+)-anrtocin was synthesized starting from com
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Wang, You-Feng, and 王友豐. "Synthesis of dihydroisoquinolin-1(2H)-one、oxazolidin-2-one and thiirane from isovanillin." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/62021734053001683017.

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碩士<br>高雄醫學大學<br>醫藥暨應用化學系碩士班<br>92<br>Part Ⅰ A novel route to substituted 3,4-dihydroisoquinolin-1(2H)-ones is established. The key intermediates, substituted o-oxiranylmethylbenzo- nitriles prepared from isovanillin via 5 steps, were respectively reacted with sodium cyanoborohydride to give a series of substituted 3,4-dihydroisoquinolin-1(2H)-one as major products. Part Ⅱ An efficient, inexpensive, and environmental concerning route to the synthesis of substituted benzonitriles bearing an oxazolidin-2-one ring from isovanillin is described. The key intermediate, o-oxiranylmethyl- benz
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Lin, Mei-Hsiang, and 林美香. "Synthesis and Pharmacology of Nonbenzopyran Analogs, 1,4-Dihydroisoquinolin-3(2H)-ones and Guanidine-base Cholesterol." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/31812631891272229183.

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博士<br>國立臺灣大學<br>藥學研究所<br>91<br>I. Synthesis and Pharmacology of Nonbenzopyran Analogs The synthesis of trans-3-[4-acyl-2-(1-methoxy-1-methylethyl)morpholin- 3-yl]benzonitriles 40 and 41 was started from 3-bromobenzonitrile, which was coupled with 2-methyl-3-butyn-2-ol followed by partial hydrogenation to afford cis olefin 51. Compound 51 was subjected to methylation and then epoxidation to give epoxide 46. Compound 46 was reacted with allylamine to produce aminoalcohol 55, which was then protected with Boc to afford 56. Ozonolysis, NaBH4 reduction, and Mitsunobu reaction transformed
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Lin, Mei-Xiang, and 林美香. "Synthesis of 7-substituted 4,4-dipyridylmethyl-2-phenyl-1,4-dihydroisoquinolin-3(2H)-ones as acetylcholine-release enhancers." Thesis, 1993. http://ndltd.ncl.edu.tw/handle/16875062971259299998.

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Lin, Mei-Hsiang, and 林美香. "Synthesis of 7-Substituted 4,4-Dipyridylmethyl-2-phenyl-1,4- dihydroisoquinolin-3(2H)-ones as Acetylcholine-Release Enhancers." Thesis, 1993. http://ndltd.ncl.edu.tw/handle/12308659790131013430.

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碩士<br>國立臺灣大學<br>藥學研究所<br>81<br>3,3-雙 ■ 啶 甲 基-1-苯 基-2-■ ■ 酮 (DuP 996) 在 老鼠的腦 組 織 中 有 明 顯 促 進 鉀 離 子 誘 導 之 乙 醯 膽 鹼 分泌 之 作 用 。 而 以 正 常 老 鼠 或 以 二 氧 化 碳 誘 導 記 憶 力 衰 退 之 老鼠 做 認 知 及 學 習 能 力 的 動 物 實 驗 , 包 括 被 動 和 主 動逃 避 試 驗 , DuP 996 亦 顯 示 有 增 進 作 用 。 最 近 以 [3H]DuP 996 標 示 的 接 受 器 亦 已 被 確 認 。 且 一 系 列 DuP 996 類似物 的 受 器 親 和 力 與 其 促 進 乙 醯 膽 鹼 分 泌 的 能 力 之 間有 相 關 性 , 反 映 出 此 受 器 具 有 相 關 的 生 理 意 義 。本實驗 先 前 合 成 出4,4- 雙 ■ 啶 甲 基-2- 苯 基-1,2,3,4-四氫異 ■ ■ -1,3-雙 酮 (1) 及 有 不 同 氮 取 代
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Chen, Po-Yuan, and 陳伯淵. "New syntheses of benzoheterocyclic derivatives: (i) flavanones; (ii) 2-substituted 3-benzylbenzofurans and (iii) 3,4-dihydroisoquinolin-1(2H)-ones." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/87931651625025683656.

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博士<br>高雄醫學大學<br>醫藥暨應用化學研究所<br>100<br>Chapter I Mild and environmentally benign methods for the syntheses of flavanones are described. The reaction of o-hydroxyacetophenones (I-1) and benzaldehydes (I-2) in water in the presence of DABCO at room temperature gave 3-hydroxy-1-(2-hydroxylphenyl)-3-arylpropan-1-ones (I-3a-i) as intermediates. Followed by an intramolecular dehydration of the 3a-i with the modified Mitsunobu’s reaction, the target flavanones (I-4a-i) were obtained. Moreover, the reaction of I-1 and I-2 at the same conditions but at reflux gave flavanones in one pot with good yields.
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Book chapters on the topic "Dihydroisoquinolines"

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Lv, Jian, Lei Lv, Xiaomin Zhang, et al. "Design, Synthesis and Biological Evaluation of the Novel Antitumor Agent 2-benzyl-3, 4-dihydroisoquinolin-1(2H)-one and Its Derivatives." In Proceedings of the 2012 International Conference on Applied Biotechnology (ICAB 2012). Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-37922-2_83.

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lvarez, M., and J. A. Joule. "Dehydrogenation of 3,4-Dihydroisoquinolines." In Six-Membered Hetarenes with One Nitrogen or Phosphorus Atom. Georg Thieme Verlag KG, 2005. http://dx.doi.org/10.1055/sos-sd-015-01265.

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lvarez, M., and J. A. Joule. "Dehydrogenation of 1,2-Dihydroisoquinolines." In Six-Membered Hetarenes with One Nitrogen or Phosphorus Atom. Georg Thieme Verlag KG, 2005. http://dx.doi.org/10.1055/sos-sd-015-01272.

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Knabe, J. "1,2-Dihydroisoquinolines and Related Compounds." In Advances in Heterocyclic Chemistry. Elsevier, 1986. http://dx.doi.org/10.1016/s0065-2725(08)60092-6.

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Wong, O. A., T. A. Ramirez, and Y. Shi. "Dihydroisoquinoline-Based Iminium and Oxaziridinium Salts." In Lewis Base and Acid Catalysts. Georg Thieme Verlag KG, 2012. http://dx.doi.org/10.1055/sos-sd-204-00427.

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"1-Oxo-6,7-dimethoxy-2-methyl-1,2-dihydroisoquinoline." In Natural Compounds. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-0560-3_887.

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lvarez, M., and J. A. Joule. "Synthesis of Phenyl 1-Allyl-1,2-dihydroisoquinoline-2-carboxylates." In Six-Membered Hetarenes with One Nitrogen or Phosphorus Atom. Georg Thieme Verlag KG, 2005. http://dx.doi.org/10.1055/sos-sd-015-01309.

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lvarez, M., and J. A. Joule. "By Dehydrogenation of 1,4-Dihydroisoquinolin-3(2)-ones." In Six-Membered Hetarenes with One Nitrogen or Phosphorus Atom. Georg Thieme Verlag KG, 2005. http://dx.doi.org/10.1055/sos-sd-015-01527.

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Schantl, J. G. "Catalytic Dehydrogenation of -Phenyl-3,4-dihydroisoquinolin-2(1)-amine Followed by [3 + 2] Cycloaddition." In Heteroatom Analogues of Aldehydes and Ketones. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-027-00681.

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Saito, Yukako, Hidekazu Ouchi, and Hiroki Takahata. "A Convenient Transformation of Carboxylic Acids to Esters Using l-tert-Butoxy-2-tert-butoxycarbonyl-1,2-dihydroisoquinoline (BBDI)." In 19th International Congress on Heterocyclic Chemistry. Elsevier, 2003. http://dx.doi.org/10.1016/b978-0-08-044304-1.50295-1.

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