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Journal articles on the topic 'Dihydrophthalazines'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Clark, Catherine, Lois M. Ednie, Gengrong Lin, et al. "Antistaphylococcal Activity of Dihydrophthalazine Antifolates, a Family of Novel Antibacterial Drugs." Antimicrobial Agents and Chemotherapy 53, no. 4 (2009): 1353–61. http://dx.doi.org/10.1128/aac.01619-08.

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ABSTRACT For a panel of 153 Staphylococcus aureus clinical isolates (including 13 vancomycin-intermediate or heterogeneous vancomycin-intermediate and 4 vancomycin-resistant strains), MIC50s and MIC90s of three novel dihydrophthalazine antifolates, BAL0030543, BAL0030544, and BAL0030545, were 0.03 and 0.25 μg/ml, respectively, for methicillin-susceptible strains and 0.03 and ≤0.25 μg/ml, respectively, for methicillin-resistant strains. For a panel of 160 coagulase-negative staphylococci (including 5 vancomycin-intermediate and heterogeneous vancomycin-intermediate strains and 7 linezolid-nonsu

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2

Caspers, Patrick, Luc Bury, Bérangère Gaucher, et al. "In Vitro and In Vivo Properties of Dihydrophthalazine Antifolates, a Novel Family of Antibacterial Drugs." Antimicrobial Agents and Chemotherapy 53, no. 9 (2009): 3620–27. http://dx.doi.org/10.1128/aac.00377-09.

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ABSTRACT Racemic 2,4-diaminopyrimidine dihydrophthalazine derivatives BAL0030543, BAL0030544, and BAL0030545 exhibited low in vitro MICs toward small, selected panels of Enterococcus faecalis, Enterococcus faecium, Streptococcus pneumoniae, Moraxella catarrhalis, and Mycobacterium avium, though the compounds were less active against Haemophilus influenzae. The constellation of dihydrofolate reductases (DHFRs) present in 20 enterococci and 40 staphylococci was analyzed and correlated with the antibacterial activities of the dihydrophthalazines and trimethoprim. DHFRs encoded by dfrB, dfrA (S1 i

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3

Lukács, Gyula, and Gyula Simig. "Synthesis of new 1,2-dihydrophthalazines." Journal of Heterocyclic Chemistry 39, no. 5 (2002): 989–96. http://dx.doi.org/10.1002/jhet.5570390520.

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4

Potikha, Lyudmyla M., Volodymyr S. Brovarets, and Victor V. Zhirnov. "Anticancer evaluation of difunctional substituted 1,2-dihydrophthalazines." Chemical Data Collections 37 (February 2022): 100817. http://dx.doi.org/10.1016/j.cdc.2021.100817.

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5

Jørgensen, K., K. Frisch, A. Landa, and S. Saaby. "Enantioselective Synthesis of 1,2-Dihydroisoquinolines and 1,2-Dihydrophthalazines." Synfacts 2006, no. 01 (2005): 0024. http://dx.doi.org/10.1055/s-2005-921690.

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6

Pei, Xue-Feng, Michael A. Sturgess, C. Fernando Valenzuela, and Maria-Luisa Maccecchini. "Allosteric modulators of the ampa receptor: Novel 6-substituted dihydrophthalazines." Bioorganic & Medicinal Chemistry Letters 9, no. 4 (1999): 539–42. http://dx.doi.org/10.1016/s0960-894x(99)00044-x.

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7

OPARIN, D. A. "ChemInform Abstract: Synthesis of 1-(2,4-Dinitrophenylhydrazono)-2,4-diaryl-1,2- dihydrophthalazines." ChemInform 25, no. 4 (2010): no. http://dx.doi.org/10.1002/chin.199404182.

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8

Pelletier, Jeffrey C., David P. Hesson, Kenneth A. Jones, and Anna-Maria Costa. "Substituted 1,2-Dihydrophthalazines: Potent, Selective, and Noncompetitive Inhibitors of the AMPA Receptor." Journal of Medicinal Chemistry 39, no. 2 (1996): 343–46. http://dx.doi.org/10.1021/jm950740w.

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9

Pei, Xue-Feng, Michael A. Sturgess, C. Fernando Valenzuela, and Maria-Luisa Maccecchini. "ChemInform Abstract: Allosteric Modulators of the AMPA Receptor: Novel 6-Substituted Dihydrophthalazines." ChemInform 30, no. 26 (2010): no. http://dx.doi.org/10.1002/chin.199926157.

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10

Aljaar, Nayyef, Jürgen Conrad, and Uwe Beifuss. "Synthesis of 2-Aryl-1,2-dihydrophthalazines via Reaction of 2-(Bromomethyl)benzaldehydes with Arylhydrazines." Journal of Organic Chemistry 78, no. 3 (2013): 1045–53. http://dx.doi.org/10.1021/jo302491x.

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11

PELLETIER, J. C., D. P. HESSON, K. A. JONES, and A. M. COSTA. "ChemInform Abstract: Substituted 1,2-Dihydrophthalazines: Potent, Selective, and Noncompetitive Inhibitors of the AMPA Receptor." ChemInform 27, no. 19 (2010): no. http://dx.doi.org/10.1002/chin.199619173.

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12

OPARIN, D. A., S. V. YAKOVLEV, and L. A. PAVLOVA. "ChemInform Abstract: Alkylation of 1-Thioxo-2-phenyl-4-aryl-1,2-dihydrophthalazines with Triethyloxonium Tetrafluoroborate." ChemInform 24, no. 10 (2010): no. http://dx.doi.org/10.1002/chin.199310223.

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13

Aljaar, Nayyef, Juergen Conrad, and Uwe Beifuss. "ChemInform Abstract: Synthesis of 2-Aryl-1,2-dihydrophthalazines via Reaction of 2-(Bromomethyl)benzaldehydes with Arylhydrazines." ChemInform 44, no. 25 (2013): no. http://dx.doi.org/10.1002/chin.201325148.

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14

Bourne, Christina R., Richard A. Bunce, Philip C. Bourne, K. Darrell Berlin, Esther W. Barrow, and William W. Barrow. "Crystal Structure of Bacillus anthracis Dihydrofolate Reductase with the Dihydrophthalazine-Based Trimethoprim Derivative RAB1 Provides a Structural Explanation of Potency and Selectivity." Antimicrobial Agents and Chemotherapy 53, no. 7 (2009): 3065–73. http://dx.doi.org/10.1128/aac.01666-08.

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ABSTRACT Bacillus anthracis possesses an innate resistance to the antibiotic trimethoprim due to poor binding to dihydrofolate reductase (DHFR); currently, there are no commercial antibacterials that target this enzyme in B. anthracis. We have previously reported a series of dihydrophthalazine-based trimethoprim derivatives that are inhibitors for this target. In the present work, we have synthesized one compound (RAB1) displaying favorable 50% inhibitory concentration (54 nM) and MIC (≤12.8 μg/ml) values. RAB1 was cocrystallized with the B. anthracis DHFR in the space group P212121, and X-ray

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15

Neumann, Helfried, Stefan Klaus, Markus Klawonn, et al. "A New Efficient Synthesis of Substituted Luminols Using Multicomponent Reactions." Zeitschrift für Naturforschung B 59, no. 4 (2004): 431–38. http://dx.doi.org/10.1515/znb-2004-0411.

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AbstractA new general synthesis of substituted luminols (5-amino-2,3-dihydrophthalazine-1,4-diones) is presented. Diversely substituted luminol derivatives can be synthesized in three steps. The products are of interest as new materials, which exhibit chemiluminescence.

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16

Bowker, Karen E., Patrick Caspers, Bérengère Gaucher, and Alasdair P. MacGowan. "In Vitro Activities of Three New Dihydrofolate Reductase Inhibitors against Clinical Isolates of Gram-Positive Bacteria." Antimicrobial Agents and Chemotherapy 53, no. 11 (2009): 4949–52. http://dx.doi.org/10.1128/aac.00845-09.

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ABSTRACT BAL0030543, BAL0030544, and BAL0030545 are dihydrophthalazine inhibitors with in vitro potency against gram-positive pathogens. The MIC50s for methicillin (meticillin)-sensitive Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, hetero-vancomycin-resistant Staphylococcus aureus, and vancomycin-resistant Staphylococcus aureus (VISA) range from 0.015 to 0.25 μg/ml (MIC90s ≤ 0.5 μg/ml). MIC50s for beta-hemolytic streptococci range from 0.03 to 0.06 μg/ml, MIC50s for Streptococcus pneumoniae range from 0.06 to 0.12 μg/ml, MIC50s for Listeria monocytogenes range from 0.015

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17

Vijay, Kumar Salvi, Pemawat Gangotri, Bapna Archita, and L. Talesara G. "Synthesis, characterization and antimicrobial activity of substituted 3-(phthalazine-1-ylamino)alkanoic acid containing imidoxy moiety." Journal of Indian Chemical Society Vol. 86, May 2009 (2009): 491–97. https://doi.org/10.5281/zenodo.5810168.

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Synthetic Organic Chemistry Research Laboratory, Department of Chemistry, M. L. Sukhadia University, Udaipur-313 001, Rajasthan, India <em>E-mail</em> : gtalesara@yahoo.com <em>Manuscript received 12 May 2008, revised 16 January 2009, accepted 20 January 2009</em> Hydrozinolysis of phthalyl derivatives of amino acid la-c afforded [(4-oxo-3,4-dihydrophthalazine-1- yl)amino]substituted acetic acid 2a-c, which on reaction with POCI<sub>3</sub>/PCI<sub>5</sub> gave ((4-chlorophahalazine-1-yl)amino]substituted acetic acid 3a-c. This when condensed with <em>N</em>-hydroxyphthalimide/ N-hydroxysuccin

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18

Bélanger, Alain, Paul Brassard, Sylvie Laquerre, and Yves Mérand. "Synthesis and chemiluminescence of new derivatives of isoluminol." Canadian Journal of Chemistry 65, no. 6 (1987): 1392–96. http://dx.doi.org/10.1139/v87-235.

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In an attempt to improve the sensitivity of luminescent immunoassays, we have prepared some new isoluminol, 7-(N,N-dialkylamino)-5-methyl-2,3-dihydrophthalazine-1,4-diones by means of a novel procedure involving the cycloaddition of dienamines to maleic acid derivatives. These compounds are characterized by the presence of a methyl group at C-5 and give quantum yields three to five times greater than those of the most efficient isoluminols in use at present.

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19

Sridhara, A. M., K. R. Venugopala Reddy, J. Keshavayya, D. S. Ambika, Sanathkumar Goud, and S. K. Peethambar. "Synthesis and Antimicrobial Studies of Some New 3-Isoxazoline Substituted Phthalazine Methylsulfonyl Oxadiazoles." E-Journal of Chemistry 8, no. 3 (2011): 1022–29. http://dx.doi.org/10.1155/2011/356437.

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A series of new 3-isoxazoline substituted phthalazine methylsulfonyl-oxadiazoles were prepared from methyl 2-(4-oxo-3,4-dihydrophthalazin-1-yl) acetate. The structure of synthesized compounds were characterized by spectral data and screened for their antimicrobial activities against various bacteria and fungi strains. Several of these compounds showed antimicrobial activity.

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20

Belousova, A. V., K. V. Sokolova, I. G. Danilova, M. V. Chereshneva, and V. A. Chereshnev. "Features of beta cell differentiation during the development of type 2 diabetes mellitus." Medical Immunology (Russia) 26, no. 5 (2024): 1037–44. http://dx.doi.org/10.15789/1563-0625-fob-16880.

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Type 2 diabetes mellitus is characterized by a mild inflammatory reaction in the pancreas, which affects the structure and function of the pancreatic islets: the number of β-cells decreases and the number of α-cells increases. The work examined the features of β-cell differentiation in the development of experimental type 2 diabetes mellitus and while reducing the inflammatory process. Biochemical, histological methods, enzyme-linked immunosorbent assay, immunohistochemical methods were used using primary antibodies to insulin, glucagon, proliferation marker Ki-67 and secondary antibodies labe

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21

Hall, Iris H., E. Stacy Hall, and Oi T. Wong. "The anti-neoplastic activity of 2,3-dihydrophthalazine-1,4-dione and N-butyl-2,3-dihydrophthalazine-1,4-dione in human and murine tumor cells." Anti-Cancer Drugs 3, no. 1 (1992): 55–62. http://dx.doi.org/10.1097/00001813-199202000-00010.

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22

Liang, Ling-Ling, Jian-She Zhao, and Seik Weng Ng. "4-Hydroxy-1-oxo-1,2-dihydrophthalazine-6,7-dicarboxylic acid dihydrate." Acta Crystallographica Section E Structure Reports Online 64, no. 7 (2008): o1225. http://dx.doi.org/10.1107/s1600536808014347.

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23

Tayde, D., U. Gawai, R. Nikam, V. Ingale, and M. Lande. "Hydrothermal Synthesis of In2O3-SiO2 as Recyclable Mesostructured Catalyst Utilized for 2,3-Dihydrophthalazine-1,4-dione (DHP) Derivatives." Asian Journal of Chemistry 35, no. 2 (2023): 507–12. http://dx.doi.org/10.14233/ajchem.2023.24060.

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Mesostructured In2O3-SiO2 as recyclable heterogeneous catalyst material was synthesized by an aqueous solution based wet chemistry method, i.e. hydrothermal method and utilized for the reaction between pathalic anhydride and substituted hydrazine hydrate in DMF medium to synthesize 2,3-dihydrophthalazine-1,4-dione (DHP) derivatives. The advantages of this protocol are cost effective, ease of handling and environmental friendly. This catalytic material were characterized by using X-ray diffraction spectroscopy, scanning electron microscopy, energy dispersive spectroscopy, Fourier transform infr

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24

Nesterov, V. N., V. E. Shklover, Yu T. Struchkov, K. A. Potekhin, V. N. Lisitsin, and A. G. Borovkov. "Structure of 7,12-dihydrophthalazino[2,3-b]phthalazine-5,14-dithione." Acta Crystallographica Section C Crystal Structure Communications 41, no. 12 (1985): 1771–73. http://dx.doi.org/10.1107/s0108270185009398.

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25

Suman, M., B. Vijayabhaskar, U. K. Syam Kumar, and B. Venkateswara Rao. "One-pot three-component green synthesis of novel dihydrophthalazine-1,4-diones." Russian Journal of General Chemistry 87, no. 9 (2017): 2039–44. http://dx.doi.org/10.1134/s1070363217090201.

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26

SACZEWSKI, F., and M. GDANIEC. "ChemInform Abstract: Synthesis and Structure of Novel 1,2-Dihydrophthalazine Containing Betaines." ChemInform 29, no. 49 (2010): no. http://dx.doi.org/10.1002/chin.199849196.

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27

Warrener, Ronald N., Douglas N. Butler, and Davor Margetic. "Preparation of the First Isobenzofuran Containing Two Ring Nitrogens: A New Diels - Alder Diene for the Synthesis of Molecular Scaffolds Containing One or More End-Fused 3,6-Di(2-pyridyl)pyridazine Ligands." Australian Journal of Chemistry 56, no. 8 (2003): 811. http://dx.doi.org/10.1071/ch03045.

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Preparation of a stable, crystalline isobenzofuran containing two ring-nitrogen atoms, 4,7-di(2-pyridyl)-5,6-diazaisobenzofuran (diaza-IBF) (12), is reported here for the first time. Diaza-IBF was prepared using the s-tetrazine-induced fragmentation of 1,4-di(2-pyridyl)-5,8-epoxy-5,8-dihydrophthalazine (9), for which a synthesis is provided. Diaza-IBF was also prepared by flash vacuum pyrolysis (FVP) of the isomeric N-methyl-1,4-di(2-pyridyl)-5,8-epoxy-5,6,7,8-tetrahydrophthalazine-6,7-dicarboximides (18) and (19), formed in three steps from furan, N-methyl maleimide, and 3,6-di(2-pyridyl)-s-t

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28

Prasanna, M. K., M. Sithambaresan, K. Pradeepkumar, and M. R. Prathapachandra Kurup. "2-{(E)-[(2Z)-2-(1,2-Dihydrophthalazin-1-ylidene)hydrazinylidene]methyl}phenol." Acta Crystallographica Section E Structure Reports Online 69, no. 10 (2013): o1522—o1523. http://dx.doi.org/10.1107/s1600536813024203.

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29

Wu, Dao-Xin, Zheng-Wang Chen, Ye-Guo Ren, and Ming-Zhi Huang. "3-tert-Butyl-4-oxo-3,4-dihydrophthalazin-1-yl 3,5-dimethylbenzoate." Acta Crystallographica Section E Structure Reports Online 64, no. 1 (2007): o8. http://dx.doi.org/10.1107/s1600536807061089.

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30

Degirmenci, Aysun, Ömer Sonkaya, Caner Soylukan, Tuğçe Karaduman, and Fatih Algi. "BODIPY and 2,3-Dihydrophthalazine-1,4-Dione Conjugates As Heavy Atom-Free Chemiluminogenic Photosensitizers." ACS Applied Bio Materials 4, no. 6 (2021): 5090–98. http://dx.doi.org/10.1021/acsabm.1c00328.

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31

Hall, Iris H., C. Brent Oswald, Steven D. Wyrick, James H. Maguire, and Robert P. Shrewsbury. "Disposition of the Hypolipidaemic Agent, 2,3-Dihydrophthalazine-1,4-dione, in Sprague Dawley Rats." Journal of Pharmacy and Pharmacology 41, no. 6 (1989): 394–97. http://dx.doi.org/10.1111/j.2042-7158.1989.tb06484.x.

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32

Liu, Xiang-Jun, Hong-Jian Zhang, and Zhe-Shan Quan. "Synthesis and evaluation of the anticonvulsant activities of 2,3-dihydrophthalazine-1,4-dione derivatives." Medicinal Chemistry Research 26, no. 9 (2017): 1935–46. http://dx.doi.org/10.1007/s00044-017-1896-8.

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33

Mirahmadpour, Pari, Davood Nematollahi, Saied Saeed Hosseiny Davarani, and Fahimeh Varmaghani. "Electrochemical Oxidation of 2,3-dihydrophthalazine-1,4-dione in the Presence of Indole Derivatives." Journal of The Electrochemical Society 160, no. 11 (2013): G156—G158. http://dx.doi.org/10.1149/2.116311jes.

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34

Haider, Norbert, Emilia Mavrokordatou, and Andreas Steinwender. "A Simple and Efficient Route To Cycloalkene-Fused 2,3-Dihydrophthalazine-1(4H),4-Diones." Synthetic Communications 29, no. 9 (1999): 1577–84. http://dx.doi.org/10.1080/00397919908086138.

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35

Degirmenci, Aysun, and Fatih Algi. "Synthesis, chemiluminescence and energy transfer efficiency of 2,3-dihydrophthalazine-1,4-dione and BODIPY dyad." Dyes and Pigments 140 (May 2017): 92–99. http://dx.doi.org/10.1016/j.dyepig.2017.01.037.

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36

Izuogu, David Chukwuma, Jonnie Niyi Asegbeloyin, Mukesh M. Jotani, and Edward R. T. Tiekink. "2-[(2,4,6-Trimethylbenzene)sulfonyl]phthalazin-1(2H)-one: crystal structure, Hirshfeld surface analysis and computational study." Acta Crystallographica Section E Crystallographic Communications 76, no. 5 (2020): 697–702. http://dx.doi.org/10.1107/s2056989020005101.

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The X-ray crystal structure of the title phthalazin-1-one derivative, C17H16N2O3S {systematic name: 2-[(2,4,6-trimethylbenzene)sulfonyl]-1,2-dihydrophthalazin-1-one}, features a tetrahedral sulfoxide-S atom, connected to phthalazin-1-one and mesityl residues. The dihedral angle [83.26 (4)°] between the organic substituents is consistent with the molecule having the shape of the letter V. In the crystal, phthalazinone-C6-C—H...O(sulfoxide) and π(phthalazinone-N2C4)–π(phthalazinone-C6) stacking [inter-centroid distance = 3.5474 (9) Å] contacts lead to a linear supramolecular tape along the a-axi

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37

Huang, Dong-liang, Xiu-Lin Fang, Qiu-Yun Chen, Qiang Wang, and Jing Gao. "Polymer United Fe2O3 Nanospheroids for Water Oxidation and the Green Synthesis of 2,3-Dihydrophthalazine-1,4-dione." ACS Sustainable Chemistry & Engineering 6, no. 9 (2018): 11280–85. http://dx.doi.org/10.1021/acssuschemeng.8b00528.

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38

Haider, Norbert, Emilia Mavrokordatou, and Andreas Steinwender. "ChemInform Abstract: A Simple and Efficient Route to Cycloalkene-Fused 2,3-Dihydrophthalazine-1(4H),4-diones." ChemInform 30, no. 29 (2010): no. http://dx.doi.org/10.1002/chin.199929153.

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39

Frisch, Kim, Aitor Landa, Steen Saaby, and Karl Anker Jørgensen. "Organocatalytic Diastereo- and Enantioselective Annulation Reactions—Construction of Optically Active 1,2-Dihydroisoquinoline and 1,2-Dihydrophthalazine Derivatives." Angewandte Chemie 117, no. 37 (2005): 6212–17. http://dx.doi.org/10.1002/ange.200501900.

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40

Frisch, Kim, Aitor Landa, Steen Saaby, and Karl Anker Jørgensen. "Organocatalytic Diastereo- and Enantioselective Annulation Reactions—Construction of Optically Active 1,2-Dihydroisoquinoline and 1,2-Dihydrophthalazine Derivatives." Angewandte Chemie International Edition 44, no. 37 (2005): 6058–63. http://dx.doi.org/10.1002/anie.200501900.

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41

Allen, Robert C. "Haloperoxidase-Catalyzed Luminol Luminescence." Antioxidants 11, no. 3 (2022): 518. http://dx.doi.org/10.3390/antiox11030518.

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Common peroxidase action and haloperoxidase action are quantifiable as light emission from dioxygenation of luminol (5-amino-2,3-dihydrophthalazine-1,4-dione). The velocity of enzyme action is dependent on the concentration of reactants. Thus, the reaction order of each participant reactant in luminol luminescence was determined. Horseradish peroxidase (HRP)-catalyzed luminol luminescence is first order for hydrogen peroxide (H2O2), but myeloperoxidase (MPO) and eosinophil peroxidase (EPO) are second order for H2O2. For MPO, reaction is first order for chloride (Cl−) or bromide (Br−). For EPO,

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42

Muddala, Nagendra, Baskar Nammalwar, Subhashini Selvaraju, et al. "Evaluation of New Dihydrophthalazine-Appended 2,4-Diaminopyrimidines against Bacillus anthracis: Improved Syntheses Using a New Pincer Complex." Molecules 20, no. 4 (2015): 7222–44. http://dx.doi.org/10.3390/molecules20047222.

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43

Wang, Xiaolun, Edward J. Salaski, Dan M. Berger, et al. "Structure-based design of isoindoline-1,3-diones and 2,3-dihydrophthalazine-1,4-diones as novel B-Raf inhibitors." Bioorganic & Medicinal Chemistry Letters 21, no. 23 (2011): 6941–44. http://dx.doi.org/10.1016/j.bmcl.2011.10.012.

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44

Cardia, M. C., S. Distinto, E. Maccioni, L. Bonsignore, and A. Delogu. "Synthesis and biological activity evaluation of differently substituted 1,4-dioxo-3,4-dihydrophthalazine-2(1H)-carboxamides and -carbothioamides." Journal of Heterocyclic Chemistry 40, no. 6 (2003): 1011–15. http://dx.doi.org/10.1002/jhet.5570400609.

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45

Spruit-van der Burg, A. "Emission spectra of some chemoluminescent reactions. Part II. The oxidation of derivatives of 2,3-dihydrophthalazine-1,4-dione." Recueil des Travaux Chimiques des Pays-Bas 69, no. 12 (2010): 1536–44. http://dx.doi.org/10.1002/recl.19500691210.

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46

Wan, Ke-Ke, Jie-Hui Yu, and Ji-Qing Xu. "6,6′-(Perfluoropropane-2,2-diyl)bis(2,3-dihydrophthalazine-1,4-dione)-based coordination polymers and their sensing properties towards Cr2O72−." CrystEngComm 21, no. 19 (2019): 3086–96. http://dx.doi.org/10.1039/c9ce00507b.

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The structures of six new diacylhydrazidate-based coordination polymers were reported. Based on their better photoluminescence properties, their sensing abilities towards Cr2O<sub>7</sub><sup>2−</sup> were investigated.

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47

El-Helby, Abdel Ghany A., Rezk R. Ayyad, Helmy M. Sakr, et al. "Design, synthesis, molecular modeling and biological evaluation of novel 2,3-dihydrophthalazine-1,4-dione derivatives as potential anticonvulsant agents." Journal of Molecular Structure 1130 (February 2017): 333–51. http://dx.doi.org/10.1016/j.molstruc.2016.10.052.

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48

NEMATOLLAHI, D., S. S. HOSSEINY DAVARANI, P. MIRAHMADPOUR, and F. VARMAGHANI. "Oxidative ring cleavage of 2,3-dihydrophthalazine-1,4-dione in aqueous and non-aqueous solutions: Electrochemical and kinetic studies." Journal of Chemical Sciences 126, no. 6 (2014): 1923–28. http://dx.doi.org/10.1007/s12039-014-0738-1.

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Zhou, Rui-Sha, and Jiang-Feng Song. "4-Hydroxy-6-[(4-hydroxy-1-oxo-1,2-dihydrophthalazin-6-yl)carbonyl]phthalazin-1(2H)-one." Acta Crystallographica Section E Structure Reports Online 65, no. 12 (2009): o3050. http://dx.doi.org/10.1107/s1600536809046509.

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Al-Rawashdeh, Banan H., and Mustafa M. El-Abadelah. "Synthesis and Properties of Some N-(2,3-Dihydrophthalazin-5-yl)amidrazones Incorporating Piperazines and Related Congeners." Asian Journal of Chemistry 29, no. 3 (2017): 605–8. http://dx.doi.org/10.14233/ajchem.2017.20271.

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