Relevant bibliographies by topics / Dihydroxypyrimidines

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Dihydroxypyrimidines'

Author: Grafiati
Published: 25 May 2024
Last updated: 31 July 2025

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Journal articles on the topic "Dihydroxypyrimidines"

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Powdrill, Megan H., Jerome Deval, Frank Narjes, Raffaele De Francesco, and Matthias Götte. "Mechanism of Hepatitis C Virus RNA Polymerase Inhibition with Dihydroxypyrimidines." Antimicrobial Agents and Chemotherapy 54, no. 3 (2009): 977–83. http://dx.doi.org/10.1128/aac.01216-09.

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ABSTRACT We studied the biochemical mechanisms associated with inhibition and resistance to a 4,5-dihydroxypyrimidine carboxylate that inhibits the hepatitis C virus (HCV) RNA-dependent RNA polymerase NS5B. On the basis of the structure of the pharmacophore, it has been suggested that these compounds may act as pyrophosphate (PPi) mimics. We monitored nucleotide incorporation events during the elongation phase and showed that the polymerase activity of wild-type NS5B was inhibited by the dihydroxypyrimidine at a 50% inhibitory concentration (IC50) of 0.73 μM. Enzymes with the G152E or P156L mu
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Guo, Di-Liang, Xing-Jie Zhang, Rui-Rui Wang, et al. "Structural modifications of 5,6-dihydroxypyrimidines with anti-HIV activity." Bioorganic & Medicinal Chemistry Letters 22, no. 23 (2012): 7114–18. http://dx.doi.org/10.1016/j.bmcl.2012.09.070.

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Novais, H. M., and S. Steenken. "Reactions of oxidizing radicals with 4,6-dihydroxypyrimidines as model compounds for uracil, thymine, and cytosine." Journal of Physical Chemistry 91, no. 2 (1987): 426–33. http://dx.doi.org/10.1021/j100286a034.

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Telvekar, Vikas N., and Kavitkumar N. Patel. "Pharmacophore Development and Docking Studies of the HIV-1 Integrase Inhibitors Derived from N-methylpyrimidones, Dihydroxypyrimidines, and Bicyclic Pyrimidinones." Chemical Biology & Drug Design 78, no. 1 (2011): 150–60. http://dx.doi.org/10.1111/j.1747-0285.2011.01130.x.

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Astrat'ev, A. A., D. V. Dashko, A. Yu Mershin, A. I. Stepanov, and N. A. Urazgil'deev. "ChemInform Abstract: Some Specific Features of Acid Nitration of 2-Substituted 4,6-Dihydroxypyrimidines. Nucleophilic Cleavage of the Nitration Products." ChemInform 32, no. 51 (2010): no. http://dx.doi.org/10.1002/chin.200151070.

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Winterbourn, Christine C., and Rex Munday. "Concerted Action Of Reduced Glutathione And Superoxide Dismutase In Preventing Redox Cycling Of Dihydroxypyrimidines, And Their Role In Antioxidant Defence." Free Radical Research Communications 8, no. 4-6 (1990): 287–93. http://dx.doi.org/10.3109/10715769009053361.

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Jansa, Petr, Antonín Holý, Martin Dračínský, et al. "5-Substituted 2-amino-4,6-dihydroxypyrimidines and 2-amino-4,6-dichloropyrimidines: synthesis and inhibitory effects on immune-activated nitric oxide production." Medicinal Chemistry Research 23, no. 10 (2014): 4482–90. http://dx.doi.org/10.1007/s00044-014-1018-9.

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Shi, Daqing, Lihui Niu, and Qiya Zhuang. "Clean synthesis of pyrido[2,3-d]pyrimidines in aqueous media." Journal of Chemical Research 2005, no. 10 (2005): 648–50. http://dx.doi.org/10.3184/030823405774663048.

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The reaction of substituted cinnamonitriles and 4-amino-2,6-dihydroxypyrimidine or 2,4-diamino-6-hydroxypyrimidine in water in the presence of triethylbenzylammonium chloride (TEBA) as catalyst affords a clean synthesis of pyrido[2,3-d]pyrimidine derivatives.
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Kufelnicki, Aleksander, Jan Jaszczak, Urszula Kalinowska-Lis, Cecylia Wardak, and Justyn Ochocki. "Complexes of Uracil (2,4-Dihydroxypyrimidine) Derivatives." Journal of Solution Chemistry 35, no. 5 (2006): 739–51. http://dx.doi.org/10.1007/s10953-006-9017-1.

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Novais, H. M., and S. Steenken. "ESR studies of electron and hydrogen adducts of thymine and uracil and their derivatives and of 4,6-dihydroxypyrimidines in aqueous solution. Comparison with data from solid state. The protonation at carbon of the electron adducts." Journal of the American Chemical Society 108, no. 1 (1986): 1–6. http://dx.doi.org/10.1021/ja00261a001.

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Dissertations / Theses on the topic "Dihydroxypyrimidines"

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Garlatti, Laura. "Development of Bunyavirales endonucleases inhibitors by in situ click chemistry." Electronic Thesis or Diss., Aix-Marseille, 2022. http://www.theses.fr/2022AIXM0586.

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Les virus de l'ordre des Bunyavirales constituent un problème de santé publique en raison du manque d’options thérapeutiques et de leur répartition mondiale. La protéine L gouvernant le système de réplication virale possède une activité endonucléase responsable du mécanisme du vol-de-coiffe permettant la transcription. Cette enzyme clé a été identifiée comme une cible thérapeutique de choix pour développer des antiviraux. Son mécanisme d’hydrolyse de l’ARN médié par les ions Mg2+ permet de développer des inhibiteurs chélateurs de métaux de type dicéto-acide (DCA). La synthèse guidée par la cib
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Chen, Hui-Fang, and 陳惠芳. "Self-Assembly of dihydroxypyrimidine-based Metal Complexes." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/40715693163039617195.

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碩士<br>中國文化大學<br>應用化學研究所<br>95<br>Abstract This thesis focuses on the preparation of novel-based metal-organic frameworks based on nucleobases via self-assembly strategy and the study of the influence of pH-values and alkali hydroxide (NaOH, KOH, CsOH). We chosen two uracil-derivatives 4,6-dihydroxypyrimidine (dhp-H2) and 2,4-dihydroxypyrimidine-5-carboxylic acid (H3L1), and 2-methyl-1H-benzo[d]imidazole-5-carboxylic acid (H2L2), as potential organic ligands. At first, assembly of Ni2+, Co2+or Zn2+ ions with dhp-H2 in water or alcohol at ambient temperature led to the formation of
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Chen, Han-Yin, and 陳函听. "Self-assembly, Structures, and Properties of Coordination Compounds Based on Dihydroxypyrimidine." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/psfr2d.

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碩士<br>國立臺北科技大學<br>化學工程研究所<br>101<br>This thesis focuses on the preparation of based metal–organic frameworks based on nucleobases via a self-assembly strategy. Two uracil-derivatives, 4,6-dihydroxypyrimidine (H2dhp) and 2,4-dihydroxypyrimidine-5-carboxylic acid (H3dhpca), were selected for use as potential organic ligands. The assembly of CaII, NiII ions with 4,6-dihydroxypyrimidine (H2dhp) in water or alcohol at ambient temperature led to the formation of the discrete molecule [Ni(Hdhp)2(H2O)4] (1) and a 2D metal–organic frameworks {[Ca(Hdhp)2(H2O2)]•THF}n (2). When MnII, MgII and ZnII were r
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Book chapters on the topic "Dihydroxypyrimidines"

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Ishikawa, T. "From 5-Amino-2,6-dihydroxypyrimidine-4-carboxylic Acid." In Six-Membered Hetarenes with Two Identical Heteroatoms. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-016-01777.

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Conference papers on the topic "Dihydroxypyrimidines"

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Vu, Tuan, Xuan Nguyen, Nikolai Yudin, and Alexander Kushtaev. "KINETICS AND NITRATION MECHANISM OF 4,6-DIHYDROXYPYRIMIDINE AND ITS DERIVATIVES IN THE PRESENCE OF NITROUS ACID." In Chemistry of nitro compounds and related nitrogen-oxygen systems. LLC MAKS Press, 2019. http://dx.doi.org/10.29003/m752.aks-2019/199-205.

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You might also be interested in the extended bibliographies on the topic 'Dihydroxypyrimidines' for particular source types:
Journal articles
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