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1
Loesch, Perk. "Die Bilder zum Text." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2007. http://nbn-resolving.de/urn:nbn:de:swb:14-1176293248506-92291.
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Die ebenso glückliche, wie schöne und wertvolle Erwerbung einer Handschrift von Wilhelm Dilich (1571/72-1650) für die Handschriftensammlung der SLUB gibt Veranlassung, nicht allein diese Handschrift vorzustellen, sondern auch an ihren Verfasser zu erinnern, dessen Wirken gleichermaßen mit Hessen und Sachsen verbunden ist.
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Smolij, Oleg. "Balkerių korpuso korozinio dilimo tyrimas." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2013. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130626_134718-75033.
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Magistratūros baigiamajame darbe buvo analizuojamas jūrinio transportinio laivo korpuso korozinis dilimas ir jo priežastys, pateikiami defektacijos metodai, vertinami eksperimentinių matavimų metu gauti rezultatai. Baigiamasis darbas susideda iš teorinės, eksperimentinės ir praktinės dalies. Teorinėje dalyje apžvelgtos laivo korpuso nusidėvėjimo problemos, apžvelgti klasifikacinių bendrovių reikalavimai laivo korpuso būklei, išnagrinėtos laivo korpuso remonto technologijos. Eksperimentinėje dalyje pateiktos balkerio ,,LEDI CHRIS“ korpuso konstrukcijų liekamojo storio matavimo ultragarsiniu stormačiu rezultatai, palyginti matavimų duomenys, gauti laivo korpuso defektacijos tyrimo metu 2002, 2007 ir 2012 m., nustatytos labiausiai korozinio proceso paveiktos laivo konstrukcijos. Praktinėje baigiamojo darbo dalyje buvo atlikti skaičiavimai, siekiant nustatyti laivo korpuso lakštu stipruma po korozijos poveikio ir apskaičiuota tikimybes analize.The master‘s thesis analyses the causes of the corrosive wear in marine transport ships. It is further followed by the examples of the flaw detection methods and the assessment of the results obtained through experimental measurements. The thesis has theoretical, experimental and practical parts to it. The theoretical part entails the review of the issues related to the depreciation of the ship‘s hull. Moreover, the theory includes the overview of the requirements imposed by the classification society in regards to the condition of the ship‘s hull. The thesis also brings forth the examination of the repair technology that is being used in connection to such issues. The experimental section of the thesis entails the residual thickness measurements of the hull structures obtained through the ultrasonic calipers that were applied on the bunker „LEDI CHRIS“. The comparison of the measurements‘results is also provided, based mainly on the data taken from the flaw detection test that was administered in the years 2002, 2007 and 2012. Additionally, the thesis identifies the structures of the ship that were impacted the most by the process of the corrosion. Last but not least, the practical part of the thesis presents calculations that were conducted in order to determine the durability of the ship‘s hull plating that was affected by the corrosion. The thesis concludes with the probability analysis of the corrosion causes.
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Augustinavičius, Giedrius. "Ekskavatoriaus kaušo dantų abrazyvinio dilimo tyrimas." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2008. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2008~D_20080721_105658-49960.
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Baigiamajame magistro darbe apžvelgti laboratoriniai ir praktiniai abrazyvinio dėvėjimosi tyrimų metodai. Sumontuotas ekskavatoriaus kaušo dantų abrazyvinio dėvėjimosi stendas, sudaryta nauja tyrimo metodika. Tyrimas buvo atliktas su šešiais ekskavatoriaus kaušo dantimis: trys aplydyti „Anykščių vario“, du ESAB firmų elektrodais, vienas dantis neaplydytas. Darbe ištirtos neaplydyto ir aplydytų skirtingais elektrodais ekskavatoriaus kaušo dantų abrazyvinio dėvėjimosi charakteristikos, pateiktos išvados ir rekomendacijos.The final magistracy work review laboratory and field abrasive wear test methods. New excavator bucket teeth abrasive wear tester was mounted and new research method was created. Research was developed with six excavator bucket’s teeth: three teeth were coating with “Anyksciu varis” company electrodes, two teeth were coating with ESAB company electrodes and one tooth wasn’t coating. In this work are analysing teeth that are coating with several types electrodes or without them, abrasive wear performances. It was present conclusion and recommendation.
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Andrešiūnas, Aurimas. "Bioskalių tepamųjų medžiagų dilimo slopinimo savybių tyrimas." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2011. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20110602_120441-47126.
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Šiame darbe atlikti biologinių tepamųjų medžiagų tribologinių savybių tyrimai bei aptariami gauti rezultatai. Tirtas grynas ir sekančiais priedais modifikuotas rapsų aliejus: stearino rūgštimi, oleino rūgštimi, monogliceridais, monodigliceridais bei jų kompozicijomis. Tyrimų rezultatai rodo, kad rapsų aliejus, modifikuotas įvardintomis medžiagomis bei jų mišiniais, efektyviau slopina dilimą, o trintį mažina efektyviau net už komercines biologines alyvas. Nnustatyta, kad rapsų aliejus modifikuotas oleino rūgštimi geriau slopina dilimą lyginant su grynu rapsų aliejumi. Rapsų aliejaus mišinys su 2% oleino rūgšties ir 0,5% monodigliceridų priedais ne tik užtikrina mažus trinties nuostolius tribosistemoje, bet šie nuostoliai viso standartinio keturių bandymo metu turi tendenciją mažėti.At this work there are accomplished researches of biological properties of lubricating materials bio-tribological features and disputed obtained results. This work discusses bio-tribological properties of lubricating materials results. Tests were used rapeseed oil additives modified next: stearic acid, oleic acid, monoglycerides, monodiglycerides and their compositions. Investigation shows, that the modification of rapeseed oil substances and mixtures there of effectively inhibits wear and effectively reduces friction, even for commercial bio oil. The investigation revealed that the modified rapeseed oil oleic acid improves friction surfaces to wear protection. It was found that a mixture of rapeseed oil with 2% oleic acid and 0.5% monodiglycerides accessories not only ensure the minimum of friction losses in the moment, but these losses during the test have a tendency to decrease.
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Durai, Dilip [Verfasser]. "Novel graph based algorithms for transcriptome sequence analysis / Dilip Durai." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2020. http://d-nb.info/1236897064/34.
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Kumar, Dilip [Verfasser]. "Long Memory in the Volatility of Indian Financial Market : An Empirical Analysis / Dilip Kumar." München : GRIN Verlag, 2014. http://d-nb.info/118391797X/34.
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Silva, Ilce Hanjan da. "Estudo da estrutura da série metamórfica de Dili. Implicações geodinâmicas." Master's thesis, Universidade de Évora, 2011. http://hdl.handle.net/10174/15213.
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A Série Metamórfica de Dili ou Formação de Aileu segundo Audley-Charles (1968) é
uma sequência de rochas metasedimentares que são a chave para a compreensão do
processo de colisão entre o bloco australiano e o mar de Banda. Esta sequência de rochas
sofreu um conjunto de processos tectónicos e metamórficos que implicou a sobreposição
de diferentes graus metamórficos e diversas fases tectónicas.
Neste trabalho procurou contribuir-se para o aprofundamento do conhecimento
destes processos quer pelo estudo estrutural das meso-estruturas encontradas, quer através
da ligação dessas estruturas à escala microscópica, bem como a sua petrografia e
mineralogia.
Os trabalhos realizados permitiram confirmar algumas das fases deformacionais
previamente descritas por outros autores, nomeadamente os trabalhos dos investigadores
Berry & Grady (1981a). O estudo de metamorfismo e a sua ligação às diferentes fases
tectónicas foi iniciado, porém deverá ser aprofundado, através de mais análises
petrográficas e através de geoquímica de elementos maiores e menores; ABSTRACT: The metamorphic Series of Dili or Aileu Formation according to Audley-Charles (1968)
is a sequence of metasedimentary rocks that are the key to understanding the process of collision
between the Australian block and the Banda Sea. This sequence of rocks has suffered a series of
tectonic and metamorphic processes involving the overlap of different metamorphic grades and
various tectonic phases.
In this work we intend to contribute to improve the knowledge of these processes either
by the structural study of the meso-structures found and also through the linkage of these
structures to the microscopic scale, its petrography and mineralogy.
This work allowed confirming some of the deformacional phases previously described by
other authors, notably the work of researchers Berry & Grady (1981a). The study of
metamorphism and its relations to the various tectonic phases was started, but must be deepened,
through more petrographic studies and the analysis of major and minor element geochemistry.
8
Frejd, Julia. "Magnetic Mineralogy of Nb-bearing Carbonatites from Oldoinyo Dili (Tanzania)." Thesis, Uppsala universitet, Institutionen för geovetenskaper, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-445837.
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Niobium (Nb) and Rare Earth Elements (REE’s) have in recent years received considerable attention because of their importance to the modern technical industry, and more specifically the enhanced sustainability that comes with them. The main source for Nb and REE’s on Earth are carbonatites and associated alkaline silicate rocks. This report examines the magnetic properties of rocks from the Oldoinyo Dili carbonatite complex in northern Tanzania. Previous workers have suggested a link between the Fe-bearing mineralogy and the formation of Nb-mineralizations at Oldoinyo Dili. This hypothesis is further examined in this report by combining detailed petrographic observations and withnew measurements of magnetic susceptibility. The aim is to see if any correlation exists between occurrence of Nb-mineralizations and the types of Fe-minerals present at Oldoinyo Dili. Based on the magnetic susceptibility measurements, at least two different species of Fe-minerals arefound in the examined samples. These are characterized by different magnetic trends during heating/cooling and also by their separate Curie temperatures (Tc). In combination with the petrographic observations these minerals are interpreted to be magnetite (Fe2O4) with Tc ~580°C, and a mineral that most likely represents a solid solution between ilmenite (FeTiO3) and hematite (Fe2O3) with Tc ~300°C. Here, no clear link between the type of opaque mineral(s) present and the total Nb content of the carbonatites can be conclusively determined based on the petrography and the magnetic measurements alone. Although the results of this report provide an important first step towards understanding the relationship between Nb-mineralizations and the magnetic mineralogy at Oldoinyo Dili, more detailed analyses of the mineral chemistry is a necessity to fully understand their complex relations and the specific conditions under which they formed.Niob (Nb) och sällsynta jordartsmetaller (REE’s) har på senare år fått stor uppmärksamhet för sin betydelse för den moderna tekniska industrin, och specifikt för den förhöjda hållbarhet som de bidrar med. Den huvudsakliga källan till Nb och REE’s på jorden är karbonatiter och associerade alkalisilikater. Denna rapport undersöker de magnetiska egenskaperna för karbonatit-komplexet Oldoinyo Dili i norra Tanzania. Forskare har tidigare anat att det finns en koppling mellan Fe-bärande mineralogi och bildandet av Nb-mineraliseringar vid Oldoinyo Dili. Denna hypotes undersöks vidare i denna rapport genom att kombinera detaljerade petrografiska observationer med nya mätningar av magnetisk susceptibilitet. Syftet är att undersöka om det finns någon korrelation mellan förekomst av Nb-mineraliseringar och de typer av järnmineral som finns vid Oldoinyo Dili. Baserat på de genomförda magnetiska susceptibilitets-mätningarna så finns det åtminstone två olika sorters järnmineral i de undersökta proverna. De karaktäriseras av olika magnetiska trender vid upphettning/nedkylning och även av sina olika Curietemperaturer (Tc). Kombinerat med petrografiska observationer uttolkas att dessa mineral är magnetit (Fe2O4) med Tc ~580°C, samt en mineral som troligen är en solid solution av ilmenit (FeTiO3) och hematit (Fe2O3) med Tc ~300°C. Det går inte att senågon tydlig koppling mellan förekommande opaka mineral och det totala Nb-innehållet i karbonatiterna med säkerhet enbart utifrån petrografin och de genomförda magnetiska mätningarna. Resultaten av denna rapport utgör ett bra första steg mot att förstå relationen mellan Nb-mineraliseringar och den magnetiska mineralogin för Oldoinyo Dili, men mer detaljerade analyser av mineralkemin är nödvändigt för att till fullo förstå de komplexa förhållanden som råder vid bildning av dessa.
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Sheth, Mihir Dilip [Verfasser], and Jan [Akademischer Betreuer] Kohlhaase. "Locally analytic representations in the moduli spaces of Lubin-Tate / Mihir Dilip Sheth ; Betreuer: Jan Kohlhaase." Duisburg, 2018. http://d-nb.info/1153337959/34.
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Gulmez, Sinem. "EPIHAM Drug-induced liver injury leading to hospital admission : a study in national healthcare insurance databases." Thesis, Bordeaux, 2017. http://www.theses.fr/2017BORD0592.
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L’objectif principal de l’étude était d’identifier les principaux médicaments associés aux hépatites aiguës (HA) associé aux médicaments (HAM) en France. Trois approches méthodologiques ont été définies. L’approche méthodologique principale est l’analyse cas-population. Les autres approches sont cas-propre témoin et cas témoins.Les cas ont été identifiés parmi les patients adultes présents dans le SNIIRAM, ayant une première hospitalisation entre 01/01/2010-31/12/2014 dont le diagnostic principal est une atteinte hépatique toxique (Classification Internationale des Maladies (CIM-10) K71.1, K71.2, K71.6, K71.9) ou une insuffisance hépatique(CIM-10 K72.0). La population de référence a été définie à partir de l’EGB. La date index (DI) considérée est la date de première hospitalisation pour HA. Les délivrances de l’ensemble des traitements précédant la DI ont été étudiées en considérant une exposition variant de 7 à 60 jours avant la DI. Les produits les plus fréquemment retrouvés sont classiques: antalgiques et en premier lieu le paracétamol, puis les produits à visée digestive symptomatique (inhibiteur de la pompe à protons, prokinétique, antispasmodique). Les suivants sont l’amoxicilline seule ou associée à l’acide clavulanique, l’ibuprofène, la codéine associée et le furosémide. L’ensemble de ces résultats pourra informer les autorités sanitaires, les praticiens et les patients sur le risque associé à chacune de ces molécules tant au plan individuel (risque absolu, risque attribuable), qu’au sein d’une famille de produits(risque relatif) ainsi que plus globalement pour la population et le système de santé(nombre absolu de cas attribuables)The main objective of EPIHAM study is to identify the main drugs associated with drug induced liver injury leading to hospital admission (DILIH) in France and the event rates associated with DILIH. Three methodological approaches were defined. Principal approach is case-population. The others are case-crossover and case control analyses. Cases were identified among adult patients present in SNIIRAM database having a first hospitalization between 01/01/2010-2010/31/12/1204, the main diagnosis of which is toxic liver disease (diagnostic codes according to the International Classification of Diseases (ICD-10) K71.1, K71.2, K71.6, K71.9) orK72.0. Reference population was defined from the EGB. Index date (ID) was considered as the date of hospital admission for DILI. The dispensations of all treatments preceding the ID were studied by considering an exposure windowvarying from 7 to 60 days before ID. The most frequently found are classical: analgesics and firstly paracetamol, followed by drugs acting on digestive system (proton pump inhibitors, prokinetics, antispasmodics). The following were amoxicillinalone or combined with clavulanic acid, ibuprofen, codeine combinations, and furosemide. These results can inform health authorities, practitioners and patients about the acute hepatitis risk leading to hospitalisation associated with each of these molecules, both individually (absolute risk, attributable risk) and within a therapeutic drug family (relative risk) as well as more generally for the population and the health system (absolute number of attributable cases)
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Maitra, Dilip D. [Verfasser]. "Regeln und Prinzipien. : Zur Soziologie juristischer Argumentation am Beispiel persönlichkeitsrechtlicher Normbildung im Bereich der Genanalyse. / Dilip D. Maitra." Berlin : Duncker & Humblot, 2019. http://d-nb.info/1238353398/34.
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Wewering, Franziska [Verfasser]. "Charakterisierung der Chemikalien-induzierten Leberschädigung („Drug-Induced Liver Injury“ – DILI) / Franziska Wewering." Berlin : Freie Universität Berlin, 2017. http://d-nb.info/1141678403/34.
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Frank, Uswatta Liyanage Dilini Chrischon Madhurangi [Verfasser]. "Kollagenfolie als Träger zur Transplantation von Zellen im subretinalen Raum für den Ersatz des RPE in AMD / Uswatta Liyanage Dilini Chrischon Madhurangi Frank." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2011. http://d-nb.info/1018203753/34.
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Holkar, Rohit Dilip [Verfasser], Ralf [Akademischer Betreuer] Meyer, Jean [Akademischer Betreuer] Renault, and Thomas [Akademischer Betreuer] Schick. "Topological construction of C*-correspondences for groupoid C*-algebras / Rohit Dilip Holkar. Gutachter: Jean Renault ; Thomas Schick. Betreuer: Ralf Meyer." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2015. http://d-nb.info/1076398677/34.
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Ribas, Juliana Rodrigues. "Direito, economia e organiza??es : uma an?lise dos deveres de prote??o e dilig?ncia nos contratos de trabalho." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2016. http://tede2.pucrs.br/tede2/handle/tede/7415.
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This dissertation analyzes the contractual duties of employment relationship trough Law, Economics and Organization Theory, limiting the study to the employer?s duty to protect the employee and the employee from diligent work. This research, also, asks the conception of man in the Brazilian work contract seeks a more sophisticated answer considering the framework of the Consolidation of Labor Laws, explores the similarities and differences between the decision-making process of the employee and the employer, inquires the dogmas of conflict in Labor Law, that is presented since the 19th century, theme which inaugurates the First Chapter. Still, It presents the labor contract as the legal instrument that creates employment relations and legal subordination, investigating its subjects and refining legal rules about its existence, execution, termination and flexibility. This dissertation likewise ruminates on the duties in contractual labor relations, lists introductory notions of Economic Analysis of Labor Law, focusing on different economic perspectives of labor contracts, and defends the inclusion of ethical values into Economic Analysis of Law, focusing on the protection of employees in work accidents perception, environmental protection of work and human capital investment. Finally, this work ascertains the employee?s identification and commitment and its connection to diligence, the attempt to insert Brazilian Profit Participation in Labor Market and the connection between the job satisfaction and its turnover, thinking about the trust dynamics between the subjects in the employment relationships and about the influences of Brazil?s protectionist legal system; lastly, this work is concluded trough a proposal of reconciliation between work value and the pursuit of profit through the (re) adaptation of the decision-making process of the business organization.
Esta disserta??o analisa por meio do Direito, da Economia e da Administra??o os deveres contratuais da rela??o de emprego. Limita o estudo ao dever do empregador de prote??o ao empregado e do empregado de presta??o de trabalho diligente. Indaga a concep??o de indiv?duo no contrato de trabalho brasileiro. Procura uma resposta sofisticada ao enquadramento da Consolida??o das Leis do Trabalho. Explora as semelhan?as e diferen?as entre o processo decis?rio do empregado e do empregador. Questiona a dogm?tica do conflito no Direito do Trabalho, que trata a rela??o de emprego ainda sob a ?tica da luta de classes retratada no s?culo XIX, tema que inaugura o primeiro cap?tulo. Apresenta o contrato de trabalho como instrumento jur?dico gerador da rela??o de emprego e da subordina??o jur?dica. Investiga seus sujeitos e apura as regras legais sobre a sua exist?ncia, execu??o, extin??o e flexibiliza??o. Reflete sobre a ?tica de deveres na rela??o contratual laboral. Disp?e no??es introdut?rias acerca da An?lise Econ?mica do Direito do Trabalho, com foco na exposi??o de diferentes perspectivas econ?micas sobre a rela??o e o contrato de trabalho. Defende a inclus?o de valores ?ticos ? An?lise Econ?mica do Direito. Observa o dever de prote??o ao empregado pelo vi?s da percep??o de acidentes de trabalho, prote??o ao meio ambiente de trabalho e investimento em capital humano. Averigua a identifica??o e comprometimento do empregado e sua rela??o com a dilig?ncia, a tentativa de implanta??o de Participa??o de Lucros ou Resultados da Empresa no Brasil e a liga??o entre a satisfa??o do emprego e a rotatividade no emprego. Reflete acerca das din?micas de confian?a entre os sujeitos da rela??o de emprego e as influ?ncias de um sistema jur?dico protecionista. Conclui propondo a concilia??o entre a valoriza??o do trabalho e a persecu??o de lucros, por meio da (re)adequa??o do processo decis?rio da organiza??o empresarial.
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Newberry, Shawn. "Laser Speckle Patterns with Digital Image Correlation." OpenSIUC, 2021. https://opensiuc.lib.siu.edu/theses/2885.
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Digital Laser Speckle Image Correlation (DiLSIC) is a technique that utilizes a laser generated speckle pattern with Digital Image Correlation (DIC). This technology eliminates the need to apply an artifact speckle pattern to the surface of the material of interest, and produces a finer speckle pattern resulting in a more sensitive analysis. This investigation explores the parameters effecting laser speckle patterns for DIC and studies DiLSIC as a tool to measure surface strain and detect subsurface defects on pressure vessels. In this study a 632.8 nm 30 mW neon-helium laser generated the speckle pattern by passing through the objective end of an objective lens. All experiments took place in a lab setting on a high performance laminar flow stabilizer optical table.This investigation began with a deeper look at the camera settings that effect the effectiveness of using laser speckles with DIC. The first studies were concentrated on the aperture size (f-stop), shutter speed, and gain (ISO) of the camera. Through a series of zero-correlation studies, translation tests, and settings studies, it was discovered that, much like white light DIC, an increased gain allowed for more noise and less reliable measurements when using DiLSIC. It was shown that the aperture size and shutter speed will largely depend on the surface composition of the material, and that these factors should be investigated with each new sample of different surface finish.To determine the feasibility of using DiLSIC on pressure vessels two samples were acquired. The first was a standard ASTM filament wound composite pressure vessel (CPV) which had an upper load limit of 40 psi. The second was a plastic vessel that had internal subsurface defects added with the use of an air pencil grinder. Both vessels were put under a pressure load with the use of a modified air compressor that allowed for multiple loading cycles through the use of a pressure relief valve. The CPV was mapped out in 10-degree increments between the 90° and 180° markings that were on the pressure vessel, occurring in three areas, each one inch apart. The CPV had a pressure load applied to at 10, 20, 30,and 40 psi. DiLSIC was able to measure increasing displacement with increased loading on the surface of the CPV, however with a load limit of 40 psi no strains were detected. The plastic vessel had known subsurface defects, and these areas were the focus of the investigation. The plastic vessel was loaded with a pressure load at 5, 10, 12, 15, 17, and 20 psi. The 5 psi loaded image was used as a reference image for the correlation and decorrelation consistently occurred at 20 psi. This investigation proved that DiLSIC can detect and locate subsurface defects through strain measurement. The results were verified with traditional white light DIC, which also showed that the subsurface defects on pressure vessels were detectable. The DIC and DiLSIC results did not agree on maximum strain measurement, with the DiLSIC prediciting much larger strains than traditional DIC. This is due to the larger effect out-of-plane displacement has on DiLSIC. DiLSIC was able to detect subsurface defects on a pressure vessel. The median measured hoop strain was in agreement for DiLSIC, DIC and the predicted hoop strain for a wall thickness of 0.1 inches. However, DiLSIC also produced unreliable maximum strain measurements. This technique shows potential for future applications, but more investigations will be needed to implement it for industrial use. A full investigation into the parameters surrounding this technique, and the factors that contribute the most to added noise and unreliability should be conducted. This technology is being developed by multiple entities and shows promising results, and once further advanced could be a useful tool for rapid surface strain measurement and subsurface defect detection in nondestructive evaluation applications. Therefore, it is recommended to continue further investigations into this technology and its applications.
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Tesfamariam, Gebremichael Te-ame [Verfasser], Abdelhak M. [Akademischer Betreuer] Zoubur, and Dilip S. [Akademischer Betreuer] Mali. "Signal Processing Techniques for Landmine Detection Using Impulse Ground Penetrating Radar (ImGPR) / Gebremichael Te-ame Tesfamariam. Betreuer: Abdelhak M. Zoubur ; Dilip S. Mali." Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2013. http://d-nb.info/1107770718/34.
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Costa, Zacarias Florêncio da. "Capital social e desenvolvimento comunitário em Timor-Leste: o caso em Suco Biqueli, Atauro; Dili, Timor-Leste." Doctoral thesis, Universidade de Évora, 2020. http://hdl.handle.net/10174/28083.
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O estudo realizado analisa as lógicas do capital social no contexto do desenvolvimento
comunitário do Suco Biqueli, Ataúro, Dili, Timor-Leste, procurando conhecer o
seu papel na mediação dos processos participativos e de empowerment, e as implicações
nos factores críticos de sucesso do desenvolvimento.
A partir de uma abordagem bottom up do desenvolvimento sobre as dinâmicas da
participação, empowerment, capital social e desenvolvimento comunitário, privilegiou-se
uma investigação qualitativa através de um estudo de caso, tendo sido realizadas nove
entrevistas semiestruturadas a informantes privilegiados, complementadas com a observação
não participante em dois trabalhos de campo intensivos em Biqueli e a análise documental
dos registos oficiais e planos de programas de desenvolvimento e relatórios de
pesquisa. O tratamento e a análise dos dados basearam-se nos pressupostos da análise
estrutural de conteúdo, complementada com o tratamento lexicométrico do corpus das
entrevistas.
Os principais resultados do estudo sugerem que o capital social é percebido como
um recurso pelos atores sociais, representando um elemento gerador de impactos positivos
no desenvolvimento comunitário, porque reforça a coesão social e a ação coletiva, e
capacita os atores sociais na luta contra a miséria e a pobreza. Verificámos ainda que
muitas das intervenções de desenvolvimento em Biqueli só existem porque se encontram
associadas ao poder das lideranças locais e dos grupos comunitários, à racionalidade decisional
das suas escolhas e à previsibilidade dos resultados esperados. Estes resultados
demonstram igualmente a presença de certos limites da racionalidade e previsibilidade
das ações implementadas, mostrando, por exemplo, que a intuição, o voluntarismo, o sentimento
de solidariedade, a confiança e a honestidade têm um papel mais decisivo do que
a “razão” na formulação de objetivos estratégicos de intervenção no desenvolvimento
comunitário, na participação direta e no empowerment comunitário; Social Capital and Community Development in East Timor:
the Case in Suco Biqueli, Atauro, Dili, East Timor
Abstract:
The research analyzes the logic of social capital in the context of community development
in Suco Biqueli, Ataúro, Dili, East Timor, seeking to know its role in mediating
participatory and empowerment processes, and the implications on critical success
factors of development.
Through a bottom up approach of development about the dynamics of participation,
empowerment, social capital and community development, a qualitative research
through a case study was favored and 9 semi-structured interviews were conducted with
key informants, complemented with non-participant observation in 2 intensive fieldwork
in Biqueli and document analysis of research reports and governmental records about
development programs and plans. Data treatment and analysis were based on structural
content analysis assumptions, complemented by lexicometric treatment of the interview
corpus.
The main results of the study suggest that social capital is perceived as a resource
by social actors, representing an element that generates positive impacts on community
development because it reinforces social cohesion and collective action, and empowers
social actors to fight against misery and poverty. We have also found that many of the
development interventions in Biqueli exist only because they are associated with the power
of locals leaders and community groups, the rationality of their choices and the predictability
of expected outcomes. These results demonstrate the presence of certain limits
of rationality and predictability of the implemented actions, showing, for example, that
intuition, voluntarism, feelings of solidarity, trust and honesty play a more decisive role
than “reason” to formulate strategic objectives for intervention in community development,
direct participation and community empowerment.
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Sarmento, Lopes Da Cruz Nizia Maria. "Analysis of Current Conditions and Future Needs of the Public Water Supply System in Dili, East Timor." Thesis, North Dakota State University, 2017. https://hdl.handle.net/10365/28199.
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This research focuses on the public water supply system in East Timor?s capital, Dili. Through this research the performance of the current public water supply system is evaluated, shortages in system capacity and operation are identified, and the future need is analyzed. Only 41.77% of Dili?s urban population currently has access to the public water supply system. A better documentation and record keeping of the water treatment plants? operations is needed. As the population grows and city develops, more water will be needed in the future. The current public water supply system will not be adequate to supply water in the future because the water demand outweighs the design capacity of the current system. Therefore, a proper water supply system and management is highly needed, especially if the government of East Timor wants to achieve their target to supply continuous water in East Timor?s urban areas by 2030.
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Liu, Dilin [Verfasser]. "Annotation, phylogenetic analysis and functional characterization of barley (Hordeum vulgare L.) WRKY transcription factors in the interaction with powdery mildew fungus Blumeria graminis / Dilin Liu." Gießen : Universitätsbibliothek, 2012. http://d-nb.info/1064838251/34.
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Douglas, O. "An evaluation of in vitro models for the assessment of mitochondrial toxicity within Drug Induced Liver Injury (DILI)." Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3012327/.
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Drug Induced Liver Injury (DILI) is of major concern to both clinicians and the pharmaceutical industry due to the attrition of lead compounds during preclinical development and the incidence of hepatotoxicity and/or the withdrawal of drugs post marketing. It has been hypothesised that drug-induced mitochondrial dysfunction (DIMD) could be a causative factor of DILI. The nucleoside analogue fialuridine (FIAU) was withdrawn from use following a clinical trial in 1993 in which 5 patients died of hepatic failure. Subsequent research has shown that FIAU induces toxicity via mitochondrial DNA damage. However, current in vitro screening methods do not identify these compounds as toxic and thus this poses a problem to pre-clinical safety assessments. Three methods of metabolic modification, utilising glucose or galactose supplemented media and 2DG were compared to define and monitor mitochondrial toxicity induced by FIAU, and positive control adefovir (ADEF), in HepG2 (human hepatocellular carcinoma) cells. The structural isomer of fialuridine, (FIAU 2’ epimer) was included as a negative control. Mitochondrial toxicity could not be demonstrated in HepG2 cells over a 7-day period by any of these drugs. The HepaRG line is evident to be more hepatocyte-like than HepG2 cells and therefore can overcome the limitations of the widely used HepG2 cells. It is hypothesised that their increased primary human hepatocyte (PHH) like phenotypic characteristics may be more suitable for drug toxicity studies. Here, the utility of HepaRG based models in the detection of mitotoxicants was compared with previous research using a HepG2 model. Bioenergetic phenotyping revealed that the HepaRG line is less metabolically active when compared to HepG2 cells. HepaRG cells have the capacity to undergo metabolic modification using a short term glucose/galactose switch method and thus detect compounds with mitochondrial liabilities (EC50-ATPglu/EC50-ATPgal >2). Following the assessment of 12 hepatotoxins it was concluded that the HepaRG line offered no increased sensitivity for the detection of mitotoxicants compared with HepG2 cells. However, their stability in culture over extended periods (1 to 4 weeks) may be advantageous for the study of delayed toxicity. Therefore, HepaRG cells were further utilised in the assessment of FIAU induced mitochondrial toxicity, using an acute metabolic screen. Mitochondrial toxicity in the absence of cell death was demonstrated following 2-week drug incubation. The measurement of cellular respiration (using Seahorse technology) demonstrated a dose-dependent decrease in mitochondrial respiration in the absence of a decrease in mitochondrial mass. Further studies demonstrated significant drug-dependent decreases in the expression of nuclear encoded complex II, mitochondria-encoded complex IV, plus a decrease in mitochondrial DNA (mtDNA). The studies have demonstrated that the HepaRG cell model is a suitable model for the study of mitochondrial toxicity induced by nucleoside antivirals with evidence indicating that the mechanism of action via effects upon mitochondrial DNA matches the clinical mechanism of hepatotoxicity. Further studies utilising HepaRG were performed to assess the chemical and molecular pathways of toxicity induced by paracetamol. The studies provided evidence that HepaRG cells have the metabolic capacity for the turnover of parent compound to the toxic metabolite NAPQI. Furthermore, acute metabolic screening demonstrated that following short term incubations the parent compound paracetamol contains a mitochondrial liability in the absence of NAPQI-induced GSH depletion. The studies within this thesis have highlighted that the HepaRG line is suitable for the detection of mitotoxicants in which toxicity is delayed or which is mediated via CYP P450 catalysed-metabolites. Additionally, the studies provide much evidence as to the power of in vitro screening models in providing fine and detailed mechanistic information.
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Novais, Rui Alexandre Sousa da Costa. "News factors in foreign news : a case study comparing British and Portuguese press coverage of the Dili Massacre." Thesis, University of Kent, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412464.
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Dilci, Burcin [Verfasser]. "Agronomic approaches in yield and quality stability of high oleic sunflowers (Helianthus annuus L.) / Burcin Dilci. Julius Kühn-Institut. Georg-August-Universität Göttingen, Fakultät für Agrarwissenschaften." Quedlinburg : Julius Kühn-Institut, 2011. http://d-nb.info/110558013X/34.
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Pophaly, Saurabh Dilip [Verfasser], Aurélien [Akademischer Betreuer] [Gutachter] Tellier, John [Gutachter] Parsch, and Klaus F. X. [Gutachter] Mayer. "Neutral and selective processes underlying genome evolution post-duplication in maize / Saurabh Dilip Pophaly ; Gutachter: John Parsch, Aurélien Tellier, Klaus F. X. Mayer ; Betreuer: Aurélien Tellier." München : Universitätsbibliothek der TU München, 2017. http://d-nb.info/1136422765/34.
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Kand, Deepashree Dilip [Verfasser], and Uta [Akademischer Betreuer] Dickhöfer. "The effects of rumen nitrogen balance on nutrient digestion, protein metabolism, and performance of dairy cows as influenced by diet composition / Deepashree Dilip Kand ; Betreuer: Uta Dickhöfer." Hohenheim : Kommunikations-, Informations- und Medienzentrum der Universität Hohenheim, 2021. http://d-nb.info/1231356707/34.
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Rangel, Felipe Augusto Barreto. "Aos sinais das Ave Marias: furtos de h?stias, feituras de prote??o e o desenho religioso da Bahia setecentista: o caso das Dilig?ncias de Muritiba." Universidade Estadual de Feira de Santana, 2015. http://localhost:8080/tede/handle/tede/146.
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Funda??o de Amparo ? Pesquisa do Estado da Bahia - FAPEB
Studies of magical practices and popular religiosities have revealed important facets of modern miscegenation. The bolsas de mandinga, one of the numerous magic instruments of protection, congregated elements and experiences of social and cultural universes disparate, fruit of religious atlantic dynamics. The processes of comprehension, elaboration and commercialization of these amulets were not as directs and revealed, because of the repressor activities of religious instances, which scoured the Portuguese overseas in search of the devil affronts to Catholic Christianity, made through the variable heterodoxies that drew in overseas. In this sense, we trace as objective to undertake a micro analysis of what we treat, while production of development processes, through documentary information, focusing on the predilection by the insertion of consecrated hosts inside the bolsas de mandinga, attentive, yet, to the motivations, contexts, experiences and understandings of involved subjects. We use a large body of documents, with a clear qualitative option, especially the inquisitorial files. We elected the written narrative in Dilig?ncias sobre o caso do desacato e sacril?gio cometido na igreja paroquial de S?o Pedro do Monte Moritiba, na Ba?a, concerning the Bahian Reconcavo, in the first half of 18th century, as the backbone of our proposal. Crossed the information present in our sources, through the evidentiary framework proposed by Carlo Ginzburg, and soaked by theoretical proposals of micro studies and trajectories, we seek to understand the religious creolization processes in Bahian Reconcavo eighteenth century. The small fragments collected through the coppery documentary lines show us how the everyday life of investigated subjects measured their spiritual universe, allowing the elaborations, called here Feituras de Prote??o.
Os estudos das pr?ticas m?gicas e religiosidades populares t?m revelado importantes facetas das mesti?agens modernas. As bolsas de mandinga, um dos in?meros instrumentos m?gicos de prote??o, congregavam elementos e experi?ncias de universos sociais e culturais d?spares, fruto das din?micas religiosas atl?nticas. Os processos de compreens?o, elabora??o e comercializa??o destes amuletos n?o eram t?o diretos e revelados, por contadas atividades repressoras das inst?ncias religiosas, que vasculhavam o ultramar luso em busca das ?afrontas do dem?nio? ao cristianismo cat?lico, feitas atrav?s das vari?veis heterodoxias que se desenhavam no al?m mar.Neste sentido, tra?amos enquanto objetivo empreenderuma micro an?lise do que tratamos enquanto processos de feituras de prote??o, atrav?s das informa??es documentais, ao enfocarmos a predile??o pela inser??o de h?stias consagradas no interior das bolsas de mandinga, atentos, ainda, ?s motiva??es, contextos, experi?ncias e entendimentos dos sujeitos envolvidos.Utilizamos um vasto corpo documental, com clara op??o qualitativa, especialmente dos arquivos inquisitoriais. Elegemos a narrativa grafada nas Dilig?ncias sobre o caso do desacato e sacril?gio cometido na igreja paroquial de S?o Pedro do Monte de Moritiba, na Ba?a, referente ao Rec?ncavo baiano, na primeira metade do s?culo XVIII, como espinha dorsal de nossa proposta. Ao cruzarmos informa??es presentes em nossas fontes, atrav?s do referencial indici?rio proposto por Carlo Ginzburg, e embebidos pelas propostas te?ricas de estudos micros e trajet?rias, buscamos entender os processos de criouliza??o religiosa no Rec?ncavo baiano setecentista. Os pequenos fragmentos coletados por entre as acobreadas linhas documentais nos revelaram como a vida cotidiana dos sujeitos investigados dimensionava o universo espiritual dos mesmos, permitindo as elabora??es que chamamos aqui de feituras de prote??o.
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Aygül, Hasan Hüseyin Bal Hüseyin. "Türk modernleşme sürecinde dil olgusunun sosyolojik analizi /." Isparta : SDÜ Sosyal Bilimler Enstitüsü, 2008. http://tez.sdu.edu.tr/Tezler/TS00617.pdf.
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Chowdhary, Vivek K. "Role of miR-122 in Acetaminophen Induced Liver Injury." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1494133473685399.
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Rego, Patricia da Silva. "Dano hepático induzido por medicamentos: estudo de concordância diagnóstica das escalas Rucam, Maria & Victorino e Naranjo." Universidade do Estado do Rio de Janeiro, 2010. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=1704.
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Reação Adversa ao Medicamento (RAM) é definida como a reação a um medicamento que é nociva e não-intencional. O dano hepático induzido por medicamento (DILI) é um exemplo de RAM que pode ser muito severa e provocar casos de transplante hepático e morte. A falta de marcadores específicos ou testes para o diagnóstico de DILI conduziu ao desenvolvimento de escalas para avaliar a imputabilidade do medicamento na ocorrência do dano hepático. O presente estudo teve como objetivo caracterizar os tipos de danos hepáticos induzidos por medicamentos e investigar a concordância de três escalas utilizadas na sua identificação: RUCAM, Maria & Victorino (M&V) e Naranjo. Trata-se de um estudo seccional realizado em um hospital universitário no Rio de Janeiro em que a população fonte foi composta por 230 pacientes internados no período de junho de 2006 a novembro de 2007, que apresentaram dano hepático segundo os critérios do CIOMS (Council for Internacional Organizations of Medical Science), que consideram os resultados dos exames hepáticos e os níveis enzimáticos. Com a aplicação dos critérios CIOMS e após a exclusão das causas alternativas de dano hepático, foram identificados 41 indivíduos com suspeita de serem portadores de dano hepático induzido por medicamento. A imputabilidade do medicamento foi investigada mediante aplicação de escalas específicas para estudo da hepatotoxicidade, RUCAM e Maria & Victorino, e pela aplicação da escala Naranjo utilizada para qualquer tipo de RAM. O estimador kappa foi utilizado para interpretação da concordância entre as escalas. Foram avaliados 23 homens e 18 mulheres e a grande maioria dos pacientes (87,8%) apresentava dano hepático do tipo colestático. Todos os homens apresentavam este tipo de dano, enquanto que entre as mulheres, a distribuição foi: 72,2% para danos colestáticos, 22,2% para danos hepatocelulares e 5,6% para danos mistos. Para cada medicamento suspeito utilizado pelos pacientes foram aplicadas as escalas RUCAM, M&V e Naranjo, o que resultou em 166 avaliações. O cálculo para avaliar a concordância entre as escalas RUCAM e M&V resultou em Кw = 0, 2492, IC 95% (0,1293- 0,3617), valor superior ao encontrado na comparação entre RUCAM e Naranjo, Кw = 0,0006. A avaliação entre as escalas M&V e Naranjo com valor de Кw= 0,013 também apontou baixa concordância. Os resultados mostraram que a concordância no diagnóstico de DILI entre as escalas utilizadas é baixa, sendo, como esperado, um pouco maior quando da avaliação das escalas específicas para hepatotoxicidade (RUCAM e M&V), quando comparada às concordâncias entre estas e a escala global de Naranjo, que foi desenhada para a avaliação de todos os tipos de RAM. A aplicação de escalas para avaliação da hepatotoxicidade representa uma alternativa ao diagnóstico baseado apenas no julgamento clínico. Entretanto, a baixa concordância entre as escalas demonstra que existem limitações das definições e dos escores adotados pelos métodos que devem ser reavaliados. Espera-se que um consenso sobre definições em comum, critérios diagnósticos e terminologias oriente a construção de um novo instrumento para avaliar causalidade.ADR (Adverse Drug Reaction) is defined as a response to a drug that is noxious and unintended. Drug induced liver injury (DILI) is a type of ADR that can be very severe and result in liver failure and death. The lack of specific biomarkers or diagnostic tests for DILI led to the development of numeric scales to assess the imputability of drug in DILI cases. The aim of this present work was to describe the types of DILI and assess the agreement of three scales used for its identification: RUCAM, Maria & Victorino and Naranjo. It is a sectional study was conducted at a university hospital in Rio de Janeiro. The target population was composed of 230 inpatients between June 2006 and November 2007, who had liver injury classified according to the criteria of CIOMS (Council for Internacional Organizations of Medical Science) that consider the results of liver tests and the enzyme levels. With the use of CIOMS criteria and after the exclusion of alternative causes of liver injury, 41 inpatients were identified as suspected DILI cases. Drug causality was assessed through the use of specific scales to study cases of hepatotoxicity, RUCAM and Maria & Victorino, and with Naranjo scale, used in the evaluation of any type of ADR. Kappa statistical test was used to assess the agreement between the scales. Twenty-three men and 18 were women were evaluated. The great majority of patients (87.8%) had cholestatic liver injury. All men had cholestatic liver injury, while for women, 72.2% of the cases were cholestatic, 22.2% were hepatocelular and 5.6% were mixed cases. For each suspected drug taken by the patients, the three scales were used, with a total of 166 ratings generated for each scale. The agreement between RUCAM and M & V was Кw = 0. 2492, CI 95% (0.1293 0.3617), as compared to RUCAM and Naranjo (Кw = 0.0006). The comparison between M&V and Naranjo (Кw= 0.013) showed low agreement. Results showed low agreement between the scales used for the diagnostic of DILI. As expected, the results were a little bit higher when assessment was made with specific scales for hepatotoxicity (RUCAM and M&V), as compared to the agreement made with these scales and the global scale Naranjo, which was designed to assess all types of RAM. The use of scales to assess hepatotoxicity are an alternative to diagnosis based only on clinical judgment. However, the low agreement between the scales shows that there are limitations in definitions and methods adopted by the scores that should be reconsidered. It is hoped that a consensus on common definitions, diagnostic criteria and terminology guide the construction of a new instrument to assess causality.
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Albrecht, Wiebke [Verfasser], Jan G. [Akademischer Betreuer] Hengstler, and Carsten [Gutachter] Watzl. "Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations / Wiebke Albrecht ; Gutachter: Carsten Watzl ; Betreuer: Jan G. Hengstler." Dortmund : Universitätsbibliothek Dortmund, 2021. http://d-nb.info/1238348599/34.
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Řehořová, Magdalena. "Ochranné autorské organizace v ČR, jejich působení a prezentace činnosti." Master's thesis, Vysoká škola ekonomická v Praze, 2017. http://www.nusl.cz/ntk/nusl-360000.
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This Master's thesis entitled Author rights protection organizations in the Czech Republic - their activities and presentation focuses on the area of copyright protection, especially in the field of musical work. The aim of the thesis is to provide a comprehensive overview of the current situation of collective societies operating in the Czech Republic and to compare them in selected areas of activity. The aim of the work is also to evaluate the practical functioning of the collective societies and explain some myths that are routed by the general public about the collective administration. The theoretical part of the thesis contains the definition of basic concepts, as the basis for other chapters dealing with specific collective societies, namely OSA, INTERGRAM and DILIA. This part of the thesis is based on annual reports analysis of these organizations, as well as personal interviews and written communication with these institutions' representatives. This master thesis is particularly helpful as a summary and evaluation of collective organizations' activities that are part of the culture and therefore have a significant impact on the level of Czech and other cultures.
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Eren, Ebru. "De la culture éducative à la culture métalinguistique. Les contextualisations de la description du français dans les discours grammaticaux en Turquie." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCA112.
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Après avoir analysé l'influence de la culture éducative turque sur l'enseignement du français en Turquie (2012, J.-C. Beacco), nous en avons conclu que les pratiques éducatives y sont fondées davantage sur la grammaire, ce qui peut s’expliquer par le rattachement à la culture éducative turque. Nous poursuivons nos recherches sur les contextualisations de la description du français dans des grammaires pédagogiques qui sont élaborées par et pour des turcophones (Grammaire et contextualisations- GRAC). Ces grammaires présentant des « contextualisations », s’écartent de celles dites de référence du français pour s’adapter aux cultures éducatives et métalinguistiques des apprenants turcophones. Il est intéressant d’étudier le discours grammatical à partir de plusieurs entrées : les articles avec les changements terminologiques dont ils sont l’objet, le genre avec la création d’une catégorie inexistante en turc et les cas grammaticaux avec la production de règles d’équivalence. Une démarche complémentaire par une cyber-enquête est engagée pour identifier les contextualisations des erreurs de français les plus fréquentes en milieu scolaire et universitaire turcophone. Les données obtenues ont permis de montrer que les discours sont modelés par les cultures éducatives et métalinguistiques. Il serait opportun de faire contribuer ces grammaires « extérieures » du français à une grammaire plus « centrale » du françaisAfter having studied the impact of educational culture on French teaching (2012, J.-C. Beacco), we concluded that teaching methods applied in Turkey are mostly based on grammar. This tendency reflects the educational culture of this country. The present research focuses on the contextualization of French grammar in reference books which were written by and for Turkish-speaking people (Project of GRAC).French reference books written in Turkey contain a number of “contextualization”, resulting from educational and metalinguistic culture of Turkish students learning French. Therefore, they differed from the French edition of French grammar. For this purpose, the French grammatical discourse was analyzed in many aspects: the articles which cause the change of terms; the gender of nouns which does not exist in Turkish introduces a new grammatical classification and the grammatical cases which result in the creation of equivalent rules. A cyber-survey was prepared to find out the contextualization of the frequent errors in French in high school and university area in Turkey. All the research, showed that these discourses were modulated by the educational and metalinguistic culture. Moreover, we demonstrated that the “off-center” Turkish edition of French grammar books need to be standardized to the “central norm” of the French edition
Türk eğitim anlayışının Fransızca öğretimine etkisi incelenmiş olup (2012, J.-C. Beacco), Türkiye’de daha çok dil bilgisine dayalı bir öğretim şekli uygulandığı ve bunun da geleneksel eğitim anlayışına bağlı kalmanın bir sonucu olduğu belirlenmiştir. Fransızca dil bilgisinin Türkiye bağlamına uyarlanmış ve Türk yazarlar tarafından Türk okuyucular için kaleme alınan kaynak kitaplar üzerine çalışılmıştır (GRAC Projesi).Türkiye’de yayımlanan Fransızca kaynak kitapları bu “bağlama göre uyarlanmakta”, dolayısıyla bir Fransız yayını Fransızca dil bilgisinden uzaklaşmaktadır: bu kitaplar, Türk öğrencilerin eğitim anlayışları gereği ve dil ötesi nedenlerle farklı algıladıkları “o yabancı dile” uygun olabilmesi için uyarlanmıştır. Bu varsayımdan yola çıkarak, Fransızca dilbilgisel söylem birçok açıdan ele alınmıştır: terim değişikliğine neden olan « article », Türkçede karşılığı olmadığı için yeni bir sınıflandırmaya yol açan isimlerde cinsiyet ve iki dil arası kural denkliğine neden olan ismin halleri. İnternet ortamında yayımlanan bir anket ile Türkiye’de lise ve üniversite düzeyinde sıklıkla yapılan Fransızca yanlışların bu bağlama uyarlanması araştırılmıştır. Tüm bu veriler, bu söylemlerin Türklerin eğitim anlayışı ve dil ötesi algıları ile şekillendiğini göstermiştir. Elde edilen sonuçlar doğrultusunda ise, “merkez dışı” bu kaynak kitapların daha “merkezi” bir Fransız yayın ölçütüne kazandırılması gerekmektedir
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Pedersen, Jenny M. "ATP-Binding-Cassette Transporters in Biliary Efflux and Drug-Induced Liver Injury." Doctoral thesis, Uppsala universitet, Institutionen för farmaci, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-205355.
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Membrane transport proteins are known to influence the absorption, distribution, metabolism, excretion and toxicity (ADMET) of drugs. At the onset of this thesis work, only a few structure-activity models, in general describing P-glycoprotein (Pgp/ABCB1) interactions, were developed using small datasets with little structural diversity. In this thesis, drug-transport protein interactions were explored using large, diverse datasets representing the chemical space of orally administered registered drugs. Focus was set on the ATP-binding cassette (ABC) transport proteins expressed in the canalicular membrane of human hepatocytes. The inhibition of the ABC transport proteins multidrug-resistance associated protein 2 (MRP2/ABCC2) and bile salt export pump (BSEP/ABCB11) was experimentally investigated using membrane vesicles from cells overexpressing the investigated proteins and sandwich cultured human hepatocytes (SCHH). Several previously unknown inhibitors were identified for both of the proteins and predictive in silico models were developed. Furthermore, a clear association between BSEP inhibition and clinically reported drug induced liver injuries (DILI) was identified. For the first time, an in silico model that described combined inhibition of Pgp, MRP2 and breast cancer resistance protein (BCRP/ABCG2) was developed using a large, structurally diverse dataset. Lipophilic weak bases were more often found to be general ABC inhibitors in comparison to other drugs. In early drug discovery, in silico models can be used as predictive filters in the drug candidate selection process and membrane vesicles as a first experimental screening tool to investigate protein interactions. In summary, the present work has led to an increased understanding of molecular properties important in ABC inhibition as well as the potential influence of ABC proteins in adverse drug reactions. A number of previously unknown ABC inhibitors were identified and predictive computational models were developed.
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Lan, Yu-Chin, and 藍煜欽. "Optical Multi-layers of Dilicon Dioxide and Niobium Pentoxide Deposited by Plasma-Assisted RF Sputtering Deposition." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/65973530950433081351.
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碩士輔仁大學
物理學系碩士班
104
In this study, optical films of silicon dioxide and niobium pentoxide were coated by using an RF sputtering system aided with a plasma source. Dioxide need in multilayer optical applications usually is a low refractive index material, and; niobium pentoxide is a high refractive index material. In this study, we expected that the silicon dioxide and niobium pentoxide films have a good stable refractive index and low optical absorption to develop the useful optical filters. We use home-made plasma source system to replace end-Hall ion source used in our previous study. The advantages of this plasma source are no overheating, and less contamination from the filament of Wolfram assembled in the end-Hall source. There is no issue of burning of filament during the deposition. This plasma source is derived by using a high DC voltage to dissociate the reactive gas in the source, such as oxygen. The substrate temperature significantly reduces in the deposition process, when compared with that in ion assisted deposition by end-Hall source. The optical properties of the samples are illustrated by ellipsometry and spectroscopy measurements to, analyze their refractive index and extinction coefficients and to identify the suitable parameters for coating optical thin films of silicon dioxide and niobium pentoxide. The results show that the silicon dioxide film has the best refractive index and the lowest optical absorption when deposited at the oxygen partial pressure of 70% with the ion current 1.2 mA. Moreover, the niobium pentoxide film at the oxygen partial pressure of 60% with the ion current 1.5 mA. In this study, we confirmed the plasma in the sputtering process can effectively increase the film optical quality. Keywords: silicon dioxide, niobium pentoxide, optical thin film, ellipsometry, spectroscopy
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Burman, Markéta. "Dělníci autorského práva. Agentura DILIA v období tzv. normalizace ve vzpomínkách tehdejších zaměstnanců." Master's thesis, 2019. http://www.nusl.cz/ntk/nusl-392604.
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In this thesis, I present Dilia, the Theater and Literary Agency, at the time of so-called normalization from the perspective of its employees. On the basis of available documentation, the organization's history from the beginning of 1949 until 1990 (a time of revolutionary societal changes) is mapped. Then I describe the organizational structure and different scope of work of each department and afterwards I turn back to the history again, this time with the focus on historical events, especially during the time of so-called normalization. I present the events as they were related to corresponding changes in directorship. In this thesis, I discover on the background of the era how the former employees recall their everyday life. I recall the employees' recollections of everyday life, working and private, in the context of the era. These recollections include forced membership in social organizations. Ultimately, they assess their their lives the vantage of today.
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Huang, Yun-Ching, and 黃雲清. "Thermoregulation of Miniopterus schreibersii in Dili Area, Nantou County." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/25890704004875886235.
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碩士東海大學
生物學系
88
Insectivorous bats can use daily torpor as a means of energy-saving strategies. The purpose of this study was to investigate the thermoregulatory pattern of Miniopterus schreibersii in Dili area from March 1999 to May 2000 and factors affecting their thermal regulation. This study includes three parts. First, the reproductive cycle of M. schreibersii was investigated by histological method. Female''s delayed implantation occurred from November to next February, embryonic development from January to April, parturition and lactation from May to June, post-lactation from June to August, and mating season from September to November. Second, post-flight body temperature (Tb) of freshly captured bats was recorded. The resting Tb was also monitored in laboratory. The post-flight Tb demonstrated positively correlated with ambient temperature, and affected by reproductive conditions, but not founded in sex or age. M. schreibersii entered torpor only during poor foraging condition and cold currents. Most adults tended not to use torpor and maintain high resting Tb throughout the year. There were no significant differences in using torpor between sex and reproductive stage. However, juveniles torpid more frequently than did adults. Third, the activity level and structure of singles and clusters of M. schreibersii were investigated monthly. Most M. schreibersii always roost communally and active consisting of adults and juveniles. In conclusion, food accessibility and bad weather were more important factors than others in determining the subtropical population of M. schreibersii''s entering torpor. And clustering behavior might help M. schreibersii to maintain high body temperature in field.
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TSENG, CHUN-YU, and 曾軍瑜. "A Study on the Meanings of Mingtang in the Dili Xinshu." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/59jvj3.
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碩士國立臺北藝術大學
建築與古蹟保存研究所
95
Mingtang, a thousand years thesis, people discussed its meanings of existence mostly in“rite”coverage and seldom in“custom”condition.While geomancy was formed in Tang and Sung, Mingtang was generally existed in geomantic belief as spiritual implication of rites architecture.For geomantic knowledge system, there has no process of definite discussion about Mingtang formation. This brought Mingtang an indistinct, metaphysical image in funeral culture implication. Through the adoption of the Dili Xinshu―an official funeral book which amalgamated rites and customs in the Northern Song Dynasty, the paper is discussion about Ming-tong issues, such as geomantic types, construction methods of ambit, context of ritual table.The discussion begins with Dili Xinshu, and then examine and lap two figures of the Dili Xinshu―“Five Cadence and Direction fig.”and“Ritual Table Mark fig.”for integrating ambit context of Mingtang geomancy in funeral culture. In the Dili Xinshu, the types of Mingtang include“turned mountain”and“ground center”―the former is like flat surrounded by mountains, the latter is like ritual table figuration. Their qualities and functions mostly agree with dynast Mingtang.However, the“turned mountain”type usually means fortune discrimination by propitious and baleful gods system, and“ground center”type not only has the implication of center, but also plays an important role in sustainable ritual of fair omen area. After single discussion of each type, the above two figures are lapped again so the“turned mountain”and“ground center”Mingtang can combine and offer three-level economy of divinity ambit. Plus the land selection based on five surnames cadence, the small cosmos relationship between“heaven, terra and human”is not very hard to be found.
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Dilci, Burcin [Verfasser]. "Agronomic approaches in yield and quality stability of high oleic sunflowers (Helianthus annuus L.) / presented by Burcin Dilci." 2008. http://d-nb.info/997928514/34.
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Cavaco, Maria João São Miguel Perestrelo. "Susceptibility to antituberculosis drugs-induced hepatotoxicity: a multivariate model." Master's thesis, 2019. http://hdl.handle.net/10316/90020.
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Trabalho Final do Mestrado Integrado em Medicina apresentado à Faculdade de MedicinaTuberculosis remains a pressing public health problem at a global scale, due to its incidence, morbidity and mortality. Drug-induced liver injury (DILI) is one of the most feared side effects associated with antituberculosis treatment, INH being frequently implicated. DILI is a multifactorial phenotype, influenced by the interaction of both genetic and non-genetic factors. The present study aimed to identify clinical and genetic variables associated with susceptibility to antituberculosis drugs-induced hepatotoxicity in patients with pulmonary tuberculosis. Clinical variables analyzed included age, gender, weight, smoking habits and presence of chronic diseases. Variants of four candidate genes, NAT2 (INH-metabolism), ABCB11 (bile-salts transport), IL6 (immunoinflammation and liver regeneration) and NBAS (liver failure) were assessed. The population sample included a total of 217 Caucasian patients with pulmonary tuberculosis, of whom 96 developed hepatotoxicity. Three grades of hepatotoxicity were considered: grade 1 (mild, 45 patients), grade 2 (DILI, 46 patients) and grade 3 (need for liver transplant or death, 5 patients). A logistic multivariate regression analysis was used to identify risk variables. Hardy-Weinberg equilibrium was tested by a chi-squared test.Age ≥ 60 years old (OR: 2.93; 95% CI: 1.58 – 5.43; p = 0.001) was found to be associatedwith an increased risk of hepatotoxic events in the global group with hepatotoxicity, as well as in subgroups comprising only females, males, grade 1 or grade 2 hepatitis. Female gender (OR: 2.16; 95% CI: 1.16 – 4.03; p = 0.015) and slow acetylator genotype (OR: 1.82; 95% CI: 1.02 – 3.27; p = 0.044) were also identified as predictors of hepatotoxicity. The model explains 15% of susceptibility to liver injury. For grade 1 hepatitis, the correlation between slow acetylator genotype and hepatotoxicity was also observed in the subgroup of females < 60 year old, but not in males’ subgroup. For males with grade 1 hepatitis, the presence of the CC genotype of rs2287622 variant in ABCB11 gene was associated with increased risk only for men > 60 years old (OR: 7.39; 95% CI: 1.33 – 41.04; p = 0.022). For grade 2 hepatitis, only older age and female gender were identified as risk factors.In conclusion, antituberculosis drugs-induced hepatotoxicity is a complex phenotype, difficult to predict, for which age, female gender and variants of NAT2 and ABCB11 genes, have a modest contribution. Until the mechanisms involved are revealed, a close clinical and analytical monitoring and eventually, an INH dosage adapted to the acetylator status, are the only disposable preventive measures.
A tuberculose continua a ser um importante problema de saúde pública à escala global,devido à sua incidência, morbidade e mortalidade. A hepatite induzida por drogas (DILI) é um dos efeitos secundários mais temidos associados aos fármacos antituberculosos,estando a isoniazida (INH) frequentemente envolvida. A DILI é um fenótipo multifatorial,influenciado pela interação de fatores genéticos e não genéticos, sendo difícil identificar um perfil de suscetibilidade.O presente estudo teve como objetivo identificar variáveis clínicas e genéticas associadas à suscetibilidade à hepatotoxicidade induzida por fármacos antituberculosos em pacientes com tuberculose pulmonar. As variáveis clínicas analisadas incluíram idade, sexo, peso, tabagismo e presença de doenças crónicas. Caracterizaram-se variantes de quatro genes candidatos, NAT2 (metabolismo da INH), ABCB11 (transporte de sais biliares), IL6 (imunoinflamação e regeneração hepática) e NBAS (insuficiência hepática). A amostra populacional incluiu 217 pacientes com tuberculose pulmonar, 96 dos quais desenvolveram hepatotoxicidade. Três graus de hepatotoxicidade foram considerados: grau 1 (leve, 45 pacientes), grau 2 (tóxica ou DILI, 46 pacientes) e grau 3 (necessidade de transplante hepático ou morte, 5 pacientes). Foi realizada uma regressão logística multivariada para identificar as variáveis de risco. O equilíbrio de Hardy-Weinberg foi testado pelo teste de quiquadrado.Idade ≥ 60 revelou-se um fator de risco quer quando se consideraram todos os doentes comhepatotoxicidade (OR: 2.93; 95% CI: 1.58 – 5.43; p = 0.001), quer para os subgruposincluindo apenas mulheres, homens, grau 1 ou 2 de hepatite. O sexo feminino (OR: 2.16;95% CI: 1.16 – 4.03; p = 0.015) e o genótipo de acetilador lento (OR: 1,82; 95% CI: 1,02 – 3,27; p = 0,044) também foram identificados como preditores de hepatotoxicidade. O modelo explica 15% de suscetibilidade a lesão hepática. Para a hepatite grau 1, a correlação entre genótipo de acetilador lento e hepatotoxicidade também foi observada em mulheres com menos de 60 anos de idade, mas não no grupo dos homens. Para os homens com hepatite de grau 1, a presença do genótipo CC da variante rs2287622 de gene ABCB11 associou-se a risco aumentado apenas em homens ≥ 60 anos (OR: 7.39; 95% CI: 1.33 – 41.04; p = 0.022). Para hepatite de grau 2, apenas a idade ≥ 60 anos e sexo feminino foram identificados como fatores de risco.Conclui-se que a hepatotoxicidade induzida por fármacos antituberculosos é um fenótipocomplexo, difícil de prever, para o qual a idade, sexo feminino e variáveis dos genes NAT2 e ABCB11 têm uma contribuição modesta. Até que os mecanismos envolvidos sejam desvendados, a monitorização clínica e analítica e, eventualmente, uma dosagem de INHadaptada ao genótipo de acetilação, são os únicos recursos disponíveis.
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Bei-WenPan and 潘倍汶. "The Transition of Bunun’s Song-Dance Performance: A Case Study of Dili Village." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/7jkncz.
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碩士國立成功大學
台灣文學系
102
From the angle of social science research, and with the form of performance, this paper aims to clarify the transformation of the symbolic implication of traditional song dance nowadays. Such transformation link the viewer (the audience) and the viewed (the Bununs), while the implication is transmitted out after messages are re-coded. In process of delivering messages, the change of the original symbols and the object make the viewer unable to connect the original implication during decoding message. The viewer can only link otherwise to create new functions, forming decoding after twice coding. From MALA－HODAIGIAN of Bunun, it can be seen apparently that the traditional song dance is transformed into performance. Since the original meaning has been changed, the taboos and conditions attached to the original meaning loosen. By having the tribal children and voluntary tribal people participate the art and literature group and learn traditional song dance, the new succession method is taking place in the tribe. On the other hand, the Bununs and non-tribe people has opposite position. Due to the viewer’s self-consciousness enveloped by social mainstream ideology, the process of coding and decoding has produced three interpretation attitudes—advantageous supremacy, negotiation, and opposition. The difficulty the Bununs and even all the aborigines have to face is to adjust themselves and contact with the interpretation of the viewer, so that the traditional culture may break the superficiality in form, and deliver the messages more effectively and profoundly. Finally, it can pave a path between conflict and alignment.
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Jarikote, Dilip Venkatrao [Verfasser]. "Solid phase synthesis of thiazole orange labeled peptide nucleic acids for homogeneous detection of single base mutation in DNA / von Dilip Venkatrao Jarikote." 2007. http://d-nb.info/983553203/34.
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Luís, Tânia Raquel Henriques. "Relatórios de Estágio e Monografia intitulada “Estudo do potencial para a hepatotoxicidade de medicamentos em idosos”." Master's thesis, 2018. http://hdl.handle.net/10316/84676.
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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de FarmáciaIntrodução: Segundo dados estatísticos a população mundial está a envelhecer.Consequente, tem-se verificado um aumento do número de indivíduos idosos. Devido àscaracterísticas inerentes do processo do envelhecimento o idoso torna-se mais suscetível aoaparecimento de RAMs, nomeadamente à lesão hepática induzida por fármacos (DILI). Estatem sido uma grande preocupação, tanto por parte dos profissionais de saúde, como pelasAgências Reguladoras, concretamente em idosos uma vez que são considerados de altorisco.Objetivos: Apresentar uma revisão da literatura sobre a hepatotoxicidade induzidapor fármacos em idosos. Descrever a lesão hepática, averiguar e identificar as principaisclasses farmacológicas envolvidas no processo de DILI nesta população, bem comoestabelecer uma relação entre a idade e o risco de desenvolver hepatotoxicidade. Analisar eidentificar a presença de medicamentos hepatotóxicos, nas listas de fármacos consideradosinapropriados em idosos.Métodos: A pesquisa deste trabalho foi realizada utilizando as palavras-chaves:hepatotoxicidade; DILI; lesão hepática induzida por medicamentos; idosos; medicaçãopotencialmente inapropriada, em bases de dados online da MEDLINE, nomeadamente naPubMed, SciELO e da B-on. Após a identificação e avaliação de títulos e resumos dos artigos,foi realizada uma leitura crítica e interpretativa na qual foram selecionadas as informaçõespara responder aos objetivos do estudo.Resultados: A suscetibilidade de DILI em indivíduos idosos pode estar associada amedicamentos específicos, a padrões de exposição, à polimedicação, a interaçõesmedicamentosas ou a mudanças fisiológicas relacionadas com a idade e não propriamente àidade cronológica. São necessários estudos rigorosos de farmacovigilância para detetar osriscos de DILI, particularmente decorrentes do envelhecimento.Conclusão: As classes farmacoterapêuticas que mais comumente causam DILIincluem os AINEs e os medicamentos anti-infeciosos, usados no sistema nervoso central ouno sistema cardiovascular, entre outros. As listas de medicamentos consideradosinapropriados em idosos não alertam para a possibilidade, de medicamentos consideradoshepatotóxicos, causarem lesão hepática, necessitando de uma atualização crítica das mesmasneste sentido. A suscetibilidade à hepatotoxicidade depende da interação entre aspropriedades do medicamento, os fatores do hospedeiro e ainda fatores ambientais.
Background: According to statistical data, the world population is aging.Consequently, there has been an increase in the number of elderly individuals. Due to theinherent characteristics of the aging process, the elderly become more susceptible to theappearance of ADRs, especially Drug-Induced Liver Injury (DILI). This has been a majorconcern, both by health professionals and by Regulatory Agencies, since the elderly areconsidered a high risk group.Objectives: To present a review of the literature on drug-induced hepatotoxicity inthe elderly. To describe the liver lesion, to investigate and identify the main pharmacologicalclasses involved in the DILI process in this population, as well as to establish a relationbetween age and the risk of developing hepatotoxicity. To analyze and identify the presenceof hepatotoxic drugs in the lists of drugs considered inappropriate in the elderly.Methods: The research was carried out using the following keywords:hepatotoxicity; DILI; drug induced hepatic injury; elderly; potentially inappropriatemedication in MEDLINE online databases, namely PubMed, SciELO and B-on. After theidentification and evaluation of titles and abstracts of the articles, a critical and interpretativereading was performed in which information was selected to respond to the objectives ofthe study.Results: DILI susceptibility in elderly individuals may be associated with specificmedications, exposure patterns, polimedication, drug interactions, or age-relatedphysiological changes, not necessarily chronological age. Rigorous pharmacovigilance studiesare needed to detect the risks of DILI, particularly as a result of aging.Conclusion: The pharmacotherapeutic classes that most commonly cause DILIinclude NSAIDs, anti-infective drugs used in the central nervous system or thecardiovascular system, among others. The lists of drugs considered inappropriate in theelderly do not alert to the possibility of drugs considered hepatotoxic, requiring a criticalupdate of the same. Susceptibility to hepatotoxicity depends on the interaction betweendrug properties, host factors and environmental factors.
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Kumar, Dilip [Verfasser]. "Signal and tissue specific functional characterization, and in silico modelling of the CCL5 promoter in human natural killer and glomerular mesangial cells / vorgelegt von Dilip Kumar." 2009. http://d-nb.info/100439442X/34.
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Santos, Joana Sofia Ligeiro. "Drug induced liver injury associated with TNF-α inhibitors – infliximab, adalimumab and etanercept: the role of the laboratory." Master's thesis, 2016. http://hdl.handle.net/10451/35866.
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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2016Background: Knowing and understanding safety profile of a pharmacological product is a continuous process since preclinical toxicological studies to postmarketing clinical evaluation. Although very uncommon, drug-induced liver injury (DILI) leads to drug discontinuation and withdrawn. Biologic therapies such as monoclonal antibodies and fusion proteins have revolutionized the treatment of several diseases. Thus, the main goals of this work was to review clinical reported hepatotoxic events associated with a biologic antirheumatic therapy ( infliximab, etanercept and adalimumab) and to access the importance of the laboratory monitoring in the diagnosis of a drug-induced liver injury. Methods: It was performed a systematic literature revision through analysis of scientific papers and reports, obtained from online databases and websites during the period of April to September 2016. Discussion/Conclusion: The mechanism of drug-induced liver injury is complex and not fully understood. The most common presentation of the hepatotoxicity induced by TNF-α antagonists is an autoimmune phenotype with marked hepatocellular injury, cholestasis can also occurs. After drug discontinuation and corticosteroid therapy, the outcome is positive and progression to severe liver injury is rare. Adverse hepatic events in patients on TNF-α antagonists are lower when comparing with non-biologic disease-modifying antirheumatic drugs. The clinical diagnosis and prediction of DILI is a challenge due to the lack of reliable screening methods, including laboratory markers, and diagnostic standards. In the future, better understanding of the underlying mechanisms of DILI in this group of drugs and identification of genetic or other markers of the hepatotoxicity associated with TNF-α antagonists are imperative for the development of improved preclinical screening assays to be used during clinical trials to evaluate a drug’s potential hepatotoxic effects before its release into the market.
Âmbito: Conhecer e perceber o perfil de segurança de um fármaco é um processo contínuo desde os estudos pré-clínicos toxicológicos até à avaliação clínica após a sua comercialização. Apesar de muito incomum, a lesão hepática induzida por fármacos (LHIF) tem impacto na descontinuação e retirada dos fármacos. As terapêuticas biológicas, tais como anticorpos monoclonais e proteínas da fusão revolucionaram o tratamento de várias doenças. Assim, os objetivos principais deste trabalho foi rever os eventos hepatotóxicos reportados clinicamente associados a uma terapêutica biológica anti-reumática (etanercept, infliximab e adalimumab) e avaliar a importância do laboratório no diagnóstico de uma lesão hepática induzida por fármacos. Métodos: Foi feita uma revisão sistemática da literatura, através da análise de artigos científicos e relatórios obtidos através de bases de dados online e sites, entre o período de abril a setembro de 2016. Discussão/Conclusão: O mecanismo da lesão hepática induzida por fármacos é complexo e não compreendido totalmente. A apresentação mais comum da hepatotoxicidade induzida por antagonistas do TNF-α é um fenótipo autoimune com evidente lesão hepatocelular, a colestase também pode ocorrer. Após a descontinuação do fármaco e início da terapêutica corticosteroide, o resultado é positivo, sendo que a progressão a lesão hepática grave é rara. Os efeitos adversos hepáticos em doentes com antagonistas de TNF-α são mais baixos quando comparados com medicamentos anti-reumáticos modificadores da doença não-biológicos. O diagnóstico clínico e a previsão da LHIF é um desafio devido à falta de métodos de avaliação eficazes, incluindo marcadores laboratoriais e diretrizes de diagnósticos. No futuro, compreender melhor os mecanismos subjacentes à LHIF neste grupo de fármacos e a identificação de marcadores genéticos ou outros da hepatotoxicidade associada a antagonistas do TNF-α é imperativo para o desenvolvimento de melhores testes de avaliação pré-clínica para serem utilizados durante os ensaios clínicos para avaliar os efeitos hepatotóxicos potenciais de um fármaco antes da entrada no mercado.