Relevant bibliographies by topics / DILP2

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  1. Journal articles
  2. Dissertations / Theses

Academic literature on the topic 'DILP2'

Author: Grafiati
Published: 4 June 2021
Last updated: 6 July 2024

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Journal articles on the topic "DILP2"

1

Lin, Feng, Mohammed Akhter Hossain, Stephanie Post, et al. "Total Solid-Phase Synthesis of Biologically Active Drosophila Insulin-Like Peptide 2 (DILP2)." Australian Journal of Chemistry 70, no. 2 (2017): 208. http://dx.doi.org/10.1071/ch16626.

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In the fruit fly Drosophila melanogaster, there are eight insulin-like peptides (DILPs) with DILPs 1–7 interacting with a sole insulin-like receptor tyrosine kinase (DInR) while DILP8 interacts with a single G protein-coupled receptor (GPCR), Lgr3. Loss-of-function dilp mutation studies show that the neuropeptide DILP2 has a key role in carbohydrate and lipid metabolism as well as longevity and reproduction. A better understanding of the processes whereby DILP2 mediates its specific actions is required. Consequently we undertook to prepare DILP2 as part of a larger, detailed structure–function
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2

Suzawa, Miyuki, Dalton Hilovsky, Kyle McPherson, and Michelle Bland. "PSUN336 Dietary sugar and protein differentially regulate the insulin and IGF1 homologs Dilp2 and Dilp6 in Drosophila." Journal of the Endocrine Society 6, Supplement_1 (2022): A413—A414. http://dx.doi.org/10.1210/jendso/bvac150.861.

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Abstract Growth deficits are frequently seen among children in resource-poor settings where malnutrition and chronic enteric infections are common. The insulin/IGF1 signaling pathway promotes cell and organismal growth across the animal kingdom. To better understand how malnutrition and infection impair growth, we investigated insulin/IGF1 signaling under such conditions using Drosophila as a model organism. In Drosophila, seven insulin-like peptides (Dilps) activate the insulin/IGF signaling pathway through a single known insulin receptor. Major circulating Dilps include Dilp2, produced from
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3

Goldsmith, Samuel L., and Stuart J. Newfeld. "dSmad2 differentially regulates dILP2 and dILP5 in insulin producing and circadian pacemaker cells in unmated adult females." PLOS ONE 18, no. 1 (2023): e0280529. http://dx.doi.org/10.1371/journal.pone.0280529.

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Much is known about environmental influences on metabolism and systemic insulin levels. Less is known about how those influences are translated into molecular mechanisms regulating insulin production. To better understand the molecular mechanisms we generated marked cells homozygous for a null mutation in the Drosophila TGF-β signal transducer dSmad2 in unmated adult females. We then conducted side-by-side single cell comparisons of the pixel intensity of two Drosophila insulin-like peptides (dILP2 and dILP5) in dSmad2- mutant and wild type insulin producing cells (IPCs). The analysis revealed
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4

Nässel, Dick R. "Insulin-producing cells and their regulation in physiology and behavior ofDrosophila1This review is part of a virtual symposium on recent advances in understanding a variety of complex regulatory processes in insect physiology and endocrinology, including development, metabolism, cold hardiness, food intake and digestion, and diuresis, through the use of omics technologies in the postgenomic era." Canadian Journal of Zoology 90, no. 4 (2012): 476–88. http://dx.doi.org/10.1139/z2012-009.

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Insulin-like peptide signaling regulates development, growth, reproduction, metabolism, stress resistance, and life span in a wide spectrum of animals. Not only the peptides, but also their tyrosine kinase receptors and the downstream signaling pathways are conserved over evolution. This review summarizes roles of insulin-like peptides (DILPs) in physiology and behavior of Drosophila melanogaster Meigen, 1830. Seven DILPs (DILP1–7) and one receptor (dInR) have been identified in Drosophila. These DILPs display cell and stage specific expression patterns. In the adult, DILP2, 3, and 5 are expre
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Wigby, Stuart, Cathy Slack, Sebastian Grönke, et al. "Insulin signalling regulates remating in female Drosophila." Proceedings of the Royal Society B: Biological Sciences 278, no. 1704 (2010): 424–31. http://dx.doi.org/10.1098/rspb.2010.1390.

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Mating rate is a major determinant of female lifespan and fitness, and is predicted to optimize at an intermediate level, beyond which superfluous matings are costly. In female Drosophila melanogaster , nutrition is a key regulator of mating rate but the underlying mechanism is unknown. The evolutionarily conserved insulin/insulin-like growth factor-like signalling (IIS) pathway is responsive to nutrition, and regulates development, metabolism, stress resistance, fecundity and lifespan. Here we show that inhibition of IIS, by ablation of Drosophila insulin-like peptide (DILP)-producing median
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Chiang, Meng-Hsuan, Yu-Chun Lin, Sheng-Fu Chen, et al. "Independent insulin signaling modulators govern hot avoidance under different feeding states." PLOS Biology 21, no. 10 (2023): e3002332. http://dx.doi.org/10.1371/journal.pbio.3002332.

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Thermosensation is critical for the survival of animals. However, mechanisms through which nutritional status modulates thermosensation remain unclear. Herein, we showed that hungry Drosophila exhibit a strong hot avoidance behavior (HAB) compared to food-sated flies. We identified that hot stimulus increases the activity of α′β′ mushroom body neurons (MBns), with weak activity in the sated state and strong activity in the hungry state. Furthermore, we showed that α′β′ MBn receives the same level of hot input from the mALT projection neurons via cholinergic transmission in sated and hungry sta
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7

Winant, Mattias, Kurt Buhler, Jason Clements, et al. "Genome-wide analysis identifies Homothorax and Extradenticle as regulators of insulin in Drosophila Insulin-Producing cells." PLOS Genetics 18, no. 9 (2022): e1010380. http://dx.doi.org/10.1371/journal.pgen.1010380.

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Drosophila Insulin-Producing Cells (IPCs) are the main production site of the Drosophila Insulin-like peptides or dilps which have key roles in regulating growth, development, reproduction, lifespan and metabolism. To better understand the signalling pathways and transcriptional networks that are active in the IPCs we queried publicly available transcriptome data of over 180 highly inbred fly lines for dilp expression and used dilp expression as the input for a Genome-wide association study (GWAS). This resulted in the identification of variants in 125 genes that were associated with variation
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Yang, Fujia, Minghui Xiu, Shipei Yang, et al. "Extension of Drosophila Lifespan by Astragalus polysaccharide through a Mechanism Dependent on Antioxidant and Insulin/IGF-1 Signaling." Evidence-Based Complementary and Alternative Medicine 2021 (February 24, 2021): 1–12. http://dx.doi.org/10.1155/2021/6686748.

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Historical literature and pharmacological studies demonstrate that Astragalus polysaccharide (APS) has anti-inflammatory and antioxidative effects. Studies into the longevity effects of APS are limited, and the molecular mechanism of lifespan extension by APS is not elucidated yet. Here, the longevity effect of APS was investigated in Drosophila melanogaster by feeding dose-dependent APS. APS significantly extended the lifespan and improved the reproduction. Meanwhile, APS increased locomotion, TAG level, and starvation resistance and reduced the mortality rate induced by hydrogen peroxide. Th
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Gendron, Christi M., Tuhin S. Chakraborty, Cathryn Duran, Thomas Dono, and Scott D. Pletcher. "Ring neurons in the Drosophila central complex act as a rheostat for sensory modulation of aging." PLOS Biology 21, no. 6 (2023): e3002149. http://dx.doi.org/10.1371/journal.pbio.3002149.

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Sensory perception modulates aging, yet we know little about how. An understanding of the neuronal mechanisms through which animals orchestrate biological responses to relevant sensory inputs would provide insight into the control systems that may be important for modulating lifespan. Here, we provide new awareness into how the perception of dead conspecifics, or death perception, which elicits behavioral and physiological effects in many different species, affects lifespan in the fruit fly, Drosophila melanogaster. Previous work demonstrated that cohousing Drosophila with dead conspecifics de
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Strilbytska, Olha M., Uliana V. Semaniuk, Kenneth B. Storey, Ihor S. Yurkevych, and Oleh Lushchak. "Insulin Signaling in Intestinal Stem and Progenitor Cells as an Important Determinant of Physiological and Metabolic Traits in Drosophila." Cells 9, no. 4 (2020): 803. http://dx.doi.org/10.3390/cells9040803.

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The insulin–IGF-1 signaling (IIS) pathway is conserved throughout multicellular organisms and regulates many traits, including aging, reproduction, feeding, metabolism, stress resistance, and growth. Here, we present evidence of a survival-sustaining role for IIS in a subset of gut cells in Drosophila melanogaster, namely the intestinal stem cells (ISCs) and progenitor cells. Using RNAi to knockdown the insulin receptor, we found that inhibition of IIS in ISCs statistically shortened the lifespan of experimental flies compared with non-knockdown controls, and also shortened their survival unde
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Dissertations / Theses on the topic "DILP2"

1

Schiesari, Luca. "The dilp2/5 genes control diapause inducibility." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3425834.

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Many holometabolous insects hibernate by triggering diapause, an “actively-induced” dormancy that blocks developmental functions. Yet, the nature of signals enhancing the plasticity of developmental system and underlying diapause inducibility is still elusive. We show that the “Insulin/IGF” dilp2/5 genes, encoding for developmental hormones, antagonize diapause switch in D. melanogaster and their modulation is pivotal in sensitizing the developmental system to environmental perturbations. Functional impairment of dilp2/5 signaling results in the appearance, or inhibition, of the inducible diap
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2

Werner, Jennifer Annette [Verfasser], and Linda [Akademischer Betreuer] Partridge. "Identification and characterization of differentially expressed microRNAs in adult tissues of the long-lived Drosophila dilp2-3,5 mutant / Jennifer Annette Werner. Gutachter: Linda Partridge." Köln : Universitäts- und Stadtbibliothek Köln, 2014. http://d-nb.info/1049781414/34.

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Meschi, Eleonora. "Identification de populations neuronales contrôlant la sécrétion des insulines et la croissance en fonction de la nutrition chez Drosophila melanogaster." Thesis, Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4088/document.

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La taille finale des organismes dépend de la vitesse et de la durée de croissance. Ces paramètres sont contrôlés par différentes hormones. La production d'hormone stéroïdienne détermine la fin de la période de croissance en déclenchant la maturité sexuelle, alors que la vitesse de croissance est régulée par la voie de signalisation de l’insuline/IGF (IIS). La vitesse de croissance des organismes est influencée par la nutrition. En effet, des défauts de croissance sont observés chez les individus souffrant de carence protéique chronique. La nutrition contrôle la croissance grâce à la voie de si
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Meschi, Eleonora. "Identification de populations neuronales contrôlant la sécrétion des insulines et la croissance en fonction de la nutrition chez Drosophila melanogaster." Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4088.

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La taille finale des organismes dépend de la vitesse et de la durée de croissance. Ces paramètres sont contrôlés par différentes hormones. La production d'hormone stéroïdienne détermine la fin de la période de croissance en déclenchant la maturité sexuelle, alors que la vitesse de croissance est régulée par la voie de signalisation de l’insuline/IGF (IIS). La vitesse de croissance des organismes est influencée par la nutrition. En effet, des défauts de croissance sont observés chez les individus souffrant de carence protéique chronique. La nutrition contrôle la croissance grâce à la voie de si
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5

Boone, Émilie. "Étude de dilp8, une hormone de couplage de la croissance tissulaire." Thesis, Nice, 2016. http://www.theses.fr/2016NICE4026/document.

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Au cours du développement, les organismes croissent de façon harmonieuse suivant un programme génétique intrinsèque et en adaptation avec les conditions environnementales. Chaque tissu atteint une taille cible qui est proportionnelle à la taille finale des autres organes et à celle de l’organisme. Des expériences de régénération effectuées sur différents modèles animaux ont révélé que chaque organe possède un programme autonome de croissance. Ainsi, des mécanismes de coordination entre la croissance tissulaire et le programme de développement sont nécessaires afin d’assurer une régulation fine
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Boone, Émilie. "Étude de dilp8, une hormone de couplage de la croissance tissulaire." Electronic Thesis or Diss., Nice, 2016. http://theses.unice.fr/2016NICE4026.

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Au cours du développement, les organismes croissent de façon harmonieuse suivant un programme génétique intrinsèque et en adaptation avec les conditions environnementales. Chaque tissu atteint une taille cible qui est proportionnelle à la taille finale des autres organes et à celle de l’organisme. Des expériences de régénération effectuées sur différents modèles animaux ont révélé que chaque organe possède un programme autonome de croissance. Ainsi, des mécanismes de coordination entre la croissance tissulaire et le programme de développement sont nécessaires afin d’assurer une régulation fine
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"Drosophila CORL Phenotypes Connect Mating, Longevity, and Insulin Signaling." Master's thesis, 2018. http://hdl.handle.net/2286/R.I.49054.

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abstract: Drosophila CORL (dCORL) is a central nervous system (CNS)-specific gene that is hypothesized to function in Transforming Growth Factor β signaling. It is part of the Corl multigene family that includes mouse and human homologs. dCORL is necessary for Ecdysone Receptor isoform B1 (EcR-B1) protein expression in the mushroom body, a brain region responsible for learning and memory. Beyond this, dCORL function is unknown. As dCORL expression is restricted to the CNS, co-expression experiments were performed to identify dCORL-specific neurons. In these experiments, EcR-B1 protein expressi
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8

Tran, Duy T. "Drosophila melanogaster DIAP2 regulates the anti-apoptotic function of DIAP1." 2008. http://www.library.wisc.edu/databases/connect/dissertations.html.

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Pereirinha, Joana Sofia Costa. "Cell type-specific drivers to study the Dilp8-sensitive neuroendocrine circuit." Master's thesis, 2017. http://hdl.handle.net/10316/82984.

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Dissertação de Mestrado em Biologia Celular e Molecular apresentada à Faculdade de Ciências e Tecnologia<br>Os órgãos dos animais coordenam o seu crescimento através de programas autónomos e não autónomos, que juntos originam adultos com órgãos de tamanho e proporção típicos da espécie. A capacidade dos animais de recorrerem a este programa de desenvolvimento, mesmo encarando graves perturbações ambientais e/ou de desenvolvimento, é chamada estabilidade do desenvolvimento. Em Drosophila, Dilp8, um péptido tipo-insulina, medeia a coordenação do desenvolvimento inter-orgão durante o desenvolvime
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10

Ho, Hsuan-Chung. "A Novel BTB-kelch Protein DIP2 Promotes DAPK Degradation Through Cul3 Ubiquitin Ligase Complex." 2004. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-2906200415215200.

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