Relevant bibliographies by topics / Diltiazem HCl

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters

Academic literature on the topic 'Diltiazem HCl'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Diltiazem HCl"

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Nirali, Chaudhari, Saskshee Sanika, Patel Shruti, Chandwani Jay, and Kachhiya Heta. "A Validated UV Spectroscopic method for Quantification of Lidocaine HCl and Diltiazem HCl." Journal of Advanced Research and Reviews in Medical & Medicine 1, no. 2 (2024): 12–21. https://doi.org/10.5281/zenodo.10935169.

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<em>A Simple and routinely used UV- Spectroscopic technique has been developed for estimating Lidocaine hydrochloride and Diltiazem hydrochloride in bulk and combined dosage form. The simultaneous estimation using first- order derivative analysis was 0.1 M HCl solvent, with scanning at wavelengths of 223 nm and 250 nm for quantifying lidocaine HCl and Diltiazem HCl, respectively. The concentration range for both drugs were 10-50 &micro;g/ml. Comprehensive validation encompassed linearity, Accuracy, Precision, Loss of Detection (LOD), Loss of Quantification (LOQ), Ruggedness and Robustness asse
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Rosyidi, Viddy Agustian, Ulfia Dwi Novita, and Lusia Lusia Oktora Ruma Kumala Sari. "An Optimasi Polivinil Pirolidon dan Kitosan dalam Sediaan Mucoadhesive Buccal Film Diltiazem HCl." Pustaka Kesehatan 7, no. 3 (2020): 177. http://dx.doi.org/10.19184/pk.v7i3.11543.

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Diltiazem HCl adalah golongan benzoatiazepin penghambat kanal kalsium (calcium channel blocker) yang digunakan dalam pengobatan angina pektoris, aritmia, dan hipertensi. Diltiazem HCl mengalami first pass metabolism di hati, waktu paruh yang pendek yakni 3-5 jam dan bioavailabilitas diltiazem pada pemberian oral sekitar 40%. Sediaan mucoadhesive buccal film diltiazem HCl melepaskan obat ke mukosa buccal sehingga dapat menghindari first pass metabolism karena absorpsinya melalui sistem vena yang mengalir dari pipi. Tujuan penelitian ini adalah untuk mengetahui pengaruh polimer polivinil pirolid
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Sari, Lusia Oktora Ruma Kumala, Septi Sudianingsih, and Yudi Wicaksono. "Optimasi Hidroksipropil Metilselulosa dan Polivinil Pirolidon dalam Sediaan Mucoadhesive Buccal Film Diltiazem Hidroklorida." Pustaka Kesehatan 9, no. 1 (2021): 9. http://dx.doi.org/10.19184/pk.v9i1.12228.

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Diltiazem HCl is a class of benzodiazepine calcium channel blockers used to treat angina pectoris, arrhythmias, and hypertension. Diltiazem HCl improves first-pass metabolism, a short half time of 3-5 hours, and bioavailability of diltiazem for oral administration of about 40%. Mucoadhesive buccal film diltiazem HCl releases the drug to the buccal mucosa, so the first pass metabolism can be avoided because of its absorption through the venous system that flows from the cheek. This study aimed to study HPMC polymers and polyvinyl pyrrolidone (PVP) polymers on swelling index, residence time, muc
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Shaikh, Siraj Nawaj* Md. ZuberPatel G. J. Khan Patel M. Siddik ZakirShaikh. "DESIGN AND EVALUATION OF BILAYER FLOATING TABLETS OF DILTIAZEM HCL." ndo American Journal of Pharmaceutical SciencesI 04, no. 08 (2017): 2612–21. https://doi.org/10.5281/zenodo.858667.

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The present investigation concerns design and evaluation of bilayer floating tablets of Diltiazem HCl Diltiazem HCl is Class I drug, though its reported bioavailability is only 40 %. It is having very short half life of 3 to 4 hrs. Hence many sustained release formulations were developed for Diltiazem HCl. A direct compression method was used to formulate all batches. 32 factorial design was applied to study % cumulative drug release and hardness. Super disintigrants like Sodium starch glycolate was used for immediate release layer and HPMC K200 M, Xanthan gum like polymers were used in floati
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Windriyati, Yulias Ninik, Risha Fillah Fithria, Fitria Dwi Kurniawati, and Ulfa Risalatul Mukaromah. "EVALUASI IN VITRO-IN VIVO FILM TRANDERMAL DILTIAZEM HCL DENGAN PENINGKAT PENETRASI PEG 400 SEBAGAI ANTIHIPERTENSI." JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik 16, no. 01 (2019): 1. http://dx.doi.org/10.31942/jiffk.v16i01.2922.

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ABSTRACTDiltiazem HCL is an antihypertensive that low oral bioavailability of 40%, so developed to transdermal preparations. A matrix type of transdermal patch of diltiazem HCl was prepared using polyvinyl alcohol and ethyl cellulose with PEG 400 as penetration enhancer. In vitro-in vivo evaluation were conducted to asses drug permeation through the skin and determine the effectiveness of transdermal film as an antihypertensive drug. Transdermal patches of diltiazem HCl were evaluated for physicochemical characteristics weight variation, thickness, folding endurance, moisture uptake, and drug
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Alduaij, Omar K., Rageh K. Hussein, Sharif Abu Alrub, and Sabry A. H. Zidan. "Antimicrobial activities of Diltiazem Hydrochloride: drug repurposing approach." PeerJ 12 (September 23, 2024): e17809. http://dx.doi.org/10.7717/peerj.17809.

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Background The growing concern of antibiotic-resistant microbial strains worldwide has prompted the need for alternative methods to combat microbial resistance. Biofilm formation poses a significant challenge to antibiotic efficiency due to the difficulty of penetrating antibiotics through the sticky microbial aggregates. Drug repurposing is an innovative technique that aims to expand the use of non-antibiotic medications to address this issue. The primary objective of this study was to evaluate the antimicrobial properties of Diltiazem HCl, a 1,5-benzothiazepine Ca2+ channel blocker commonly
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Triastutik, Irsalina, Lusia Oktora Ruma Kumala Sari, and Lina Winarti. "Optimasi Hydroxypropyl Methylcellulose dan Chitosan pada Tablet Floating-Mucoadhesive Diltiazem Hidroklorida Menggunakan Desain Faktorial." Pustaka Kesehatan 8, no. 3 (2020): 159. http://dx.doi.org/10.19184/pk.v8i3.11419.

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Diltiazem HCl is one of the drugs used for hypertension treatment. It requires frequent dosing, which is why diltiazem HCl needs to be formulated into preparations using a controlled release drug delivery system. The combination of floating and the mucoadhesive system is expected to increase the stomach's retention of the dosage form. This study aimed to determine the optimum composition of hydroxypropyl methylcellulose (HPMC K100M) and chitosan for floating mucoadhesive diltiazem HCl tablet. Tablets that have been prepared were evaluated for the tablet's physical characterization, powder flow
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Agrawal, Rajesh, Prasad G. Mishra, and Balkrishan Bansal. "Understanding Degradation Pathway of Poorly Stable Diltiazem Hydrochloride and Development of its Stabilized Controlled-release Tablets." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 04 (2022): 1646–49. http://dx.doi.org/10.25258/ijddt.12.4.28.

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Diltiazem hydrochloride is a class -1 drug, as per the breast-conserving surgery (BCS) classification system, which is highly soluble and highly permeable. It is a poorly stable drug that poses many problems during formulation preparation. The stability of the final product is quite challenging. The API undergoes hydrolysis to form desacetyl-diltiazem. It is the major degradation impurity. Desacetyl-diltiazem exhibits only a quarter to half of the pharmacological activity as compared to diltiazem HCl. A correct understanding of the degradation pathway and usage of suitable excipients can provi
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Ramya, Munagala Gayatri, Rajesh Akki, and Chakrala Jyothsna. "Optimization and Characterization of Fenugreek Seed Polymer Nanoparticles Loaded with Diltiazem HCl Nanoparticles by Desolvation Method." Journal of Drug Delivery and Therapeutics 9, no. 6-s (2019): 155–63. http://dx.doi.org/10.22270/jddt.v9i6-s.3769.

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The main aim of the present investigation is to optimize and evaluate the fenugreek seed polymer nanoparticles using Diltiazem HCl as a model drug because Diltiazem HCl has short half-life. Nanoparticles were prepared by using desolvation method and evaluated to study the influence of polymer concentration and stirring speed on different characteristics of nanoparticles such as particle size, surface morphology, zeta potential, Encapsulation efficiency and In-vitro drug release. FTIR, DSC and XRD studies were also performed to determine the compatibility, degradation and crystalline nature of
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Nguyen, Chien N., J. Mark Christensen, and James W. Ayres. "Formulation of Sustained-Release Verapamil HCl and Diltiazem HCl Semisolid Matrix Capsules." Pharmaceutical Development and Technology 13, no. 2 (2008): 115–25. http://dx.doi.org/10.1080/10837450701831070.

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Dissertations / Theses on the topic "Diltiazem HCl"

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Ko, Chi Yung, and 柯紀墉. "In vivo/in vitro study of effect of tabletting factors on the release of diltiazem HCl tablets." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/06233643040228069627.

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碩士<br>高雄醫學大學<br>藥學研究所<br>90<br>Diltiazem HCl was used as model drug in the study. Three factors, such as two kinds of disintegrant, three different doses of active drug, and four different compression pressures were used to study the effects on diltiazem HCl tablets from in vitro dissolution testing. Full factorial design(23) in the experimental design method was used to study whether the effects of these factors have statistical significance. The results showed that the dissolution of diltiazem HCl tablet was affected by different disintegrants and active ingredient content. Four formulations
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CHEN, SHOU-QIONG, та 陳守瓊. "Acetaminophen直打顆粒製備之可行性及Diltiazem HC1圓粒控釋劑型之開發". Thesis, 1991. http://ndltd.ncl.edu.tw/handle/17863894926254867007.

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Book chapters on the topic "Diltiazem HCl"

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Heald, Donald L., John A. Ziemniak, and Ian R. Wilding. "The Gastrointestinal Transit and Systemic Absorption of Diltiazem HCL from a Modified Release Dosage Form." In Nuclear Imaging in Drug Discovery, Development, and Approval. Birkhäuser Boston, 1993. http://dx.doi.org/10.1007/978-1-4684-6808-3_16.

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"DilTIAZem HCl." In Pediatric Injectable Drugs. American Society of Health-System Pharmacists, 2018. http://dx.doi.org/10.37573/9781585285402.084.

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Phelps, Stephanie J., Tracy M. Hagemann, and Kelley R. Lee. "DilTIAZem HCl." In Pediatric Injectable Drugs. ASHP, 2024. http://dx.doi.org/10.37573/9781585287192.096.

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Olivotto, Iacopo. "Hypertrophic cardiomyopathy: medical management of heart failure symptoms and arrhythmias." In ESC CardioMed. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0352.

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Hypertrophic cardiomyopathy (HCM) largely remains an orphan disease. In the near future, however, novel, evidence-based translational approaches are likely to revolutionize its management via the development of agents targeting disease-specific substrates. In current clinical practice, appropriate use of the available pharmacological armamentarium may provide sufficient control of most common clinical manifestations and complications, allowing normal longevity in many HCM patients. As the burden of disease is often considerable, specific experience is required for decision-making and choice of
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Boffa, Giovanni. "Cardiomyopathy." In The ESC Handbook on Cardiovascular Pharmacotherapy, edited by Claudio Ceconi, Francesca Mantovani, and Erland Erdmann. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780198759935.003.0018.

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Hypertrophic cardiomyopathy (HCM) is characterized by the presence of increased left ventricular (LV) wall thickness that is not explained by loading conditions. The LV diastolic function is impaired in the majority of patients, and resting or provocable LV outflow tract obstruction is often present. The management of HCM is directed towards minimizing symptoms, improving LV diastolic function, and reducing LV outflow tract obstrucion. Beta-blockers reduce myocardial oxygen demand and improve LV filling via their negative chronotropic and inotropic effects. Moreover, they decrease LV outflow t
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Boffa, Giovanni. "Cardiomyopathy." In The ESC Handbook on Cardiovascular Pharmacotherapy, edited by Claudio Ceconi, Francesca Mantovani, and Erland Erdmann. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780198759935.003.0018_update_001.

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Hypertrophic cardiomyopathy (HCM) is characterized by the presence of increased left ventricular (LV) wall thickness that is not explained by loading conditions. The LV diastolic function is impaired in the majority of patients, and resting or provocable LV outflow tract obstruction is often present. The management of HCM is directed towards minimizing symptoms, improving LV diastolic function, and reducing LV outflow tract obstruction. Beta-blockers reduce myocardial oxygen demand and improve LV filling via their negative chronotropic and inotropic effects. Moreover, they decrease LV outflow
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Journal articles
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