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Journal articles on the topic 'Dimedone 1'

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Published: 4 June 2025

Last updated: 23 June 2025

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1

Dietz, Wibke, Yvonne Schwerdtfeger, Uwe Klingebiel та Mathias Noltemeyer. "Bis(1-cyclohexen-3-on-1-oxy)silane, Silyl-enole von β-Ketonen/ Bis (1-cyclohexene-3-on-1-oxy)silanes, Silyl-enoles of β -Ketones". Zeitschrift für Naturforschung B 62, № 11 (2007): 1371–76. http://dx.doi.org/10.1515/znb-2007-1104.

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5,5-Dimethylcyclohexane-1,3-dione (dimedone) and cyclohexane-1,3-dione react with Cl2Si(CMe3)2 in the presence of triethylamine to give the bis(1-cyclohexene-3-on-1-oxy)dit butylsilanes 2 and 3. Using dimedone and Cl2SiMe2, the analogous dimethylsilane 1 is obtained. A 1,4-Michael-Addition occurs using cyclohexane-1,3-dione in the reaction with Cl2SiMe2 to give a spirocyclic diketone (4). The reaction of cyclohexane-1,3-dione with lithium-diisopropylamide and F3SiCMe3 leads to the formation of a salt [iPr2NH2]2HF[C6H7O2]2, 5. The crystal structures of 2 - 5 were determined.

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2

Best, WM, RFC Brown, PD Tiso, and KG Watson. "The Synthesis of Cyclohexane-1,3-diones Bearing an Isoxazoline or a Dihydro-1,2-oxazine Ring at C2." Australian Journal of Chemistry 43, no. 2 (1990): 427. http://dx.doi.org/10.1071/ch9900427.

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Dimedone (6) was C-acylated with 4-(1′-methylethylideneaminooxy) butanoic acid (7), and the product (8) was hydrolysed to give 2-(5′,6′-dihydro-4′H-1′,2′-oxazin-3′-yl)- 5,5-dimethylcyclohexane-1,3-dione (3). The 2-(4′,5′-dihydroisoxazol-3′-yl) 1,3-dione (4) was obtained in <2% yield from dimedone anion and 3-nitro-2-isoxazoline (11).

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3

Martínez-Richa, Antonio, Guillermo Mendoza-Díaz, and Pedro Joseph-Nathan. "Keto-Enol Tautomerism of Dimedone Studied by Dynamic NMR." Applied Spectroscopy 50, no. 11 (1996): 1408–12. http://dx.doi.org/10.1366/0003702963904665.

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The keto-enol tautomeric equilibrium of dimedone has been investigated by high-resolution 13C NMR spectroscopy. Kinetic information of the solution keto-enol tautomerism for dimedone in DMSO, in the temperature range of 25–85 °C, was derived from line shape measurements in a 75-MHz spectrometer. A value of 3.43 Kcal/mol was found for the Arrhenius activation energy Ea and of 1.07 × 106 s−1 for the pre-exponential factor A. With the use of the observed chemical shifts in the high-resolution 13C-NMR spectra of dimedone in the solid state, an estimate coalescence temperature of 240 K for dimedone in DMSO was obtained by extrapolation of the experimental curve. The estimated free energy of activation at the coalescence temperature, Δ Gc≠, is 10.8 Kcal/mol. Finally, the 13C spin-lattice relaxation times, T1(13C), in solid dimedone were measured as a function of temperature in the range of 25 to 90 °C. The data are discussed in terms of the different motional environments that result from the geometric restrictions imposed by hydrogen bonding in the crystal structure.

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4

Cremlyn, Richard J., Alan G. Osborne, and Joanne F. Warmsley. "NMR spectral studies of dimedone-aldehyde adducts Part 1. 1H and 13C NMR spectral studies of dimedone." Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 52, no. 11 (1996): 1423–32. http://dx.doi.org/10.1016/0584-8539(96)01695-9.

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5

Oskooie, Hossein A., Leili Tahershamsi, Majid M. Heravi, and Bita Baghernejad. "Cellulose Sulfonic Acid: An Efficient Heterogeneous Catalyst for the Synthesis of 1, 8-Dioxo-octahydroxanthenes." E-Journal of Chemistry 7, no. 3 (2010): 717–20. http://dx.doi.org/10.1155/2010/936107.

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1,8-Dioxo-octahydroxanthenes have been synthesized good yields via a reaction of aldehydes and dimedone in the presence of cellulose sulfonic acid as a heterogeneous catalyst under solvent-free condition.

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6

Ehsanifar, Sepideh, and Masoud Mokhtary. "3-Carboxy-1-sulfopyridin-1-ium chloride ([CPySO3H]+Cl−): an efficient catalyst for one-pot synthesis of hexahydroquinoline-3-carboxamides." Heterocyclic Communications 24, no. 1 (2018): 27–29. http://dx.doi.org/10.1515/hc-2017-0211.

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Abstract 3-Carboxy-1-sulfopyridin-1-ium chloride ([CPySO3H]+Cl−) was synthesized and evaluated as a recoverable catalyst for one-pot synthesis of hexahydroquinoline-3-carboxamide derivatives by a four-component reaction of an arylaldehyde, dimedone, acetoacetanilide and ammonium acetate. The [CPySO3H]+Cl− catalyst was characterized by infrared (IR), 1H nuclear magnetic resonance (NMR), 13C NMR, elemental analysis and thermal gravimetric analysis (TGA).

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7

Andin, A. N., and M. A. Engelgardt. "Synthesis of Functionalized Spiro[1-benzofuran-2,5'-pyrimidine] Derivatives of 5-Arylidenebarbituric Acids." Russian Journal of Organic Chemistry 60, no. 11 (2024): 2125–29. https://doi.org/10.1134/s1070428024110058.

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Abstract Adducts of dimedone and 5-arylidenebarbituric acids react with N-bromosuccinimide in aqueous ethanol to give functionalized spiro[1-benzofuran-2,5'-pyrimidine] derivatives with moderate yields. The reaction of 5-benzylidenebarbituric acid with ethyl acetoacetate in the presence of N-bromosuccinimide provides spiro[pyrimidine-5,6'-furo[2,3-d]pyrimidine].

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8

Abdelhamid, Ismail, Ahmed Elwahy, and Hadeer Diab. "ZnO-Nanoparticles-Catalyzed Synthesis of Poly(tetrahydrobenzimidazo[2,1-b]quinazolin-1(2H)-ones) as Novel Multi-armed Molecules." Synlett 29, no. 12 (2018): 1627–33. http://dx.doi.org/10.1055/s-0037-1609967.

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A new series of poly(tetrahydrobenzimidazo[2,1-b]-quinazolin-1(2H)-ones) was synthesized in good yields using a multicomponent reaction of poly(aldehydes), dimedone, and 2-aminobenzimidazole in DMF under conventional heating as well as under microwave irradiation.

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9

Naby, Hisham A. Abdel, Ramadan A. Mekheimer, Afaf M. Abd-Elhameed, and Kamal U. Sadek. "A Convenient One-pot Synthesis of Pyrimido[4,5-b]quinolines as 5-Deaza Non-classical Antifolate Inhibitors." Journal of Chemical Research 23, no. 11 (1999): 678–79. http://dx.doi.org/10.1177/174751989902301121.

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A convenient one-pot synthesis of pyrimido[4,5- b]quinolines as non-classical 5-deaza antifolate inhibitors by the reaction of 6-amino-4-oxo-2-thioxotetrahydropyrimidine 1 with aromatic aldehydes and dimedone is reported.

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10

Piralghar, Zahra Abdi, Mohammad Mahmoodi Hashemi, and Ali Ezabadi. "Synthesis and Characterization of a Novel Ionic Liquid Based on N,N,N,N-tetramethylethylenediamine and its Application in the Synthesis of 1,8-dioxo-octahydro Xanthenes." Combinatorial Chemistry & High Throughput Screening 21, no. 7 (2018): 526–32. http://dx.doi.org/10.2174/1386207321666180828092546.

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Aim and Objective: In this work, we synthesized and characterized a novel Brönsted acidic ionic liquid from the reaction of N, N, N’, N’-tetramethylethylenediamine with chlorosulfonic acid and explored its catalytic activity in 1, 8-dioxo-octahydroxanthenes synthesis. Materials and Methods: Dimedone, aryl aldehydes, and the ionic liquid as the catalyst were reacted under solvent-free conditions. The progressive of the reaction was monitored by a thin layer of chromatography (ethyl acetate/n-hexane = 1/5). All products were characterized as the basis of their spectra data and melting point by comparison with those reported in the literature. Results: The prepared ionic liquid was successfully applied in the synthesis of 1, 8-dioxooctahydroxanthenes in good to high yields on the reaction of aryl aldehyde and dimedone at 120oC under solvent-free conditions. Conclusion: This research demonstrates that the catalyst is impressive for 1, 8-dioxo-octahydroxanthenes synthesis under solvent-free conditions.

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11

R, Tope Dipak, Sangle Shilpa L., Agashe Jyoti A., Shelke Yogita R., and Borhade Ashok V. "Synthesis of Biologically Active Compound 1,4-Dihydropyridine by using An Efficient and Versatile Silica Supported MgO Catalyst." Der Pharma Chemica 14, no. 11 (2022): 6. https://doi.org/10.4172/0975-413X.14.11.8-13.

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A simple one pot synthesis has been developed for the synthesis 1,4-dihydropyridine using an efficient and reusable silica supported MgO solid catalyst by condensation of dimedone, ethyl acetoacetate, aldehyde and ammonium acetate in methanol as a solvent at room temperature. The reactions could be carried out under mild reaction conditions with very good yield of polyhydroquinoline, up to 92%. This catalyst could be recycled very easily, which makes this methodology environmentally benign.

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12

Pinhey, JT, та PT Xuan. "The Thermal α-Substitution of Dimedone by Vinyl Ethers". Australian Journal of Chemistry 41, № 3 (1988): 331. http://dx.doi.org/10.1071/ch9880331.

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Pyrolysis of a mixture of dimedone (1) and 1-methoxycyclohexene (2) led to formation of the enedione (3), which underwent both a Diels-Alder reaction with (2) to form the spiro compound (4), and reaction with oxygen to give the cyclic peroxide (5). The possibility of extending the initial reaction, which is thought to proceed by an ene mechanism, to some cyclic vinyl ethers has been examined.

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13

Ryzhkova, Yuliya E., Varvara M. Kalashnikova, Fedor V. Ryzhkov, Artem N. Fakhrutdinov, and Michail N. Elinson. "4a’-Hydroxy-3′,3′,5,6′,6′,7-hexamethyl-3′,4′,4a’,6′,7′,9a′-hexahydrospiro[indole-3,9′-xanthene]-1′,2,8′(1H,2′H,5′H)-trione." Molbank 2023, no. 3 (2023): M1721. http://dx.doi.org/10.3390/m1721.

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Pseudo-multicomponent reactions (Pseudo-MCRs) have led to a variety of compounds with interesting biological properties, especially desirable in the pharmaceutical industry. The isatin nucleus could be considered a privileged scaffold for the design of biologically active substances. Dimedone is an interesting and versatile molecule for most organic transformations, especially one-pot and multicomponent reactions. Xanthene derivatives are still an attractive research field for both academia investigations and industry. In this investigation, a simple and efficient tandem Knoevenagel–Michael protocol with subsequent cyclization for the synthesis of the previously unknown 4a’-hydroxy-3′,3′,5,6′,6′,7-hexamethyl-3′,4′,4a’,6′,7′,9a′-hexahydrospiro[indole-3,9′-xanthene]-1′,2,8′(1H,2′H,5′H)-trione was elaborated. The suggested method is based on the pseudo-MCR of 5,7-dimethylisatin and dimedone. The structure of the earlier unknown compound was proven using 1H, 13C-NMR, and IR spectroscopy, mass spectrometry, and elemental analysis. To compare the developed protocol with the existing ones, unsubstituted spiro[indole-3,9′-xanthene] was synthesized. Its structure has been proven using two-dimensional (2D) NMR spectroscopy techniques.

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14

M, Heravi; Majid, V. Zadsirjan, S.J. Mahdizadeh, and M. Heydari. "Synthesis of novel N -functionalized 4-aryl-tetrahydrobiquinoline-2,5-(1 H,3 H)-diones via one-pot three-component reaction: A joint experimental and computational study." Canadian Journal of Chemistry 96, no. 12 (2018): 1071–78. https://doi.org/10.1139/cjc-2017-0564.

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A novel series of N-functionalized 4-aryl-tetrahydrobiquinoline-2,5-(1H,3H)-diones were synthesized in high yields by a one-pot three-component reaction involving 2-chloroquinoline-3-carbaldehydes, Meldrum's acid, and enaminones (dimedone-based enaminones) in the presence of K<sub>2</sub>CO<sub>3</sub> in CH<sub>3</sub>CN under reflux condition. To gain a deep insight on the mechanism of the reaction, an extensive series of quantum mechanics calculations in the framework of density functional theory (DFT) were carried out for supporting the suggested reaction pathway.

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15

Hey, KB, CM Lachs, MJ Raxworthy, and EJ Wood. "Crosslinked fibrous collagen for use as a dermal implant: control of the cytotoxic effects of glutaraldehyde and dimethylsuberimidate." Biotechnology and Applied Biochemistry 12, no. 1 (1990): 85–93. http://dx.doi.org/10.1111/j.1470-8744.1990.tb00082.x.

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Collagen intended for use as a dermal implant may be crosslinked to increase its strength and persistence in vivo. Sheets of rat fibrous dermal collagen were crosslinked with either glutaraldehyde or dimethylsuberimidate and the cytotoxicity to human dermal fibroblasts resulting from these treatments was measured by following the inhibition of [3H]leucine incorporation into protein. Both agents were cytotoxic at the concentrations required to effect adequate crosslinking (0.005% and 25 mM, respectively). This cytotoxicity could be limited by extensive washing and by incubation with 5 mM L‐lysine, with 66 mM (0.25% w/v) sodium borohydride, or with 71.3 mM (1% w/v) dimedone. However, cytotoxicity was most efficiently controlled by treatment with a combination of 66 mM sodium borohydride and 5 mM L‐lysine or 66 mM sodium borohydride and 71.3 mM dimedone. [3H]Leucine incorporation by cells exposed to crosslinked collagen treated with these combinations approached 100% of the values recorded with cells exposed to uncrosslinked collagen.

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16

Mohareb, Rafat M., Amr S. Abouzied, and Nermeen S. Abbas. "Synthesis and Biological Evaluation of Novel 4,5,6,7-Tetrahydrobenzo[D]-Thiazol-2- Yl Derivatives Derived from Dimedone with Anti-Tumor, C-Met, Tyrosine Kinase and Pim-1 Inhibitions." Anti-Cancer Agents in Medicinal Chemistry 19, no. 12 (2019): 1438–53. http://dx.doi.org/10.2174/1871520619666190416102144.

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Background: Dimedone and thiazole moieties are privileged scaffolds (acting as primary pharmacophores) in many compounds that are useful to treat several diseases, mainly tropical infectious diseases. Thiazole derivatives are a very important class of compounds due to their wide range of pharmaceutical and therapeutic activities. On the other hand, dimedone is used to synthesize many therapeutically active compounds. Therefore, the combination of both moieties through a single molecule to produce heterocyclic compounds will produce excellent anticancer agents. Objective: The present work reports the synthesis of 47 new substances belonging to two classes of compounds: Dimedone and thiazoles, with the purpose of developing new drugs that present high specificity for tumor cells and low toxicity to the organism. To achieve this goal, our strategy was to synthesize a series of 4,5,6,7-tetrahydrobenzo[d]-thiazol-2-yl derivatives using the reaction of the 2-bromodimedone with cyanothioacetamide. Methods: The reaction of 2-bromodimedone with cyanothioacetamide gave the 4,5,6,7-tetrahydrobenzo[d]- thiazol-2-yl derivative 4. The reactivity of compound 4 towards some chemical reagents was observed to produce different heterocyclic derivatives. Results: A cytotoxic screening was performed to evaluate the performance of the new derivatives in six tumor cell lines. Thirteen compounds were shown to be promising toward the tumor cell lines which were further evaluated toward five tyrosine kinases. Conclusion: The results of antitumor screening showed that many of the tested compounds were of high inhibition towards the tested cell lines. Compounds 6c, 8c, 11b, 11d, 13b, 14b, 15c, 15g, 21b, 21c, 20d and 21d were the most potent compounds toward c-Met kinase and PC-3 cell line. The most promising compounds 6c, 8c, 11b, 11d, 13b, 14b, 15c, 15g, 20c, 20d, 21b, 21c and 21d were further investigated against tyrosine kinase (c-Kit, Flt-3, VEGFR-2, EGFR, and PDGFR). Compounds 6c, 11b, 11d, 14b, 15c, and 20d were selected to examine their Pim-1 kinase inhibition activity the results revealed that compounds 11b, 11d and 15c had high activities.

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17

Grigor’eva, N. G., S. V. Bubennov, A. S. Artem’eva, D. V. Serebrennikov, N. A. Filippova, and B. I. Kutepov. "Microporous and Hierarchical ZSM-5 Zeolites in Friedländer Synthesis." Petroleum Chemistry 63, no. 7 (2023): 759–68. http://dx.doi.org/10.1134/s0965544123050092.

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Abstract The study investigates the catalytic performance of microporous and granular micro–meso–macroporous zeolites (H-ZSM-5 and H-ZSM-5h, respectively) in synthesis of quinolines by the reaction of 2-aminoacetophenone with diketones (2,4-pentanedione or dimedone), known as the Friedländer synthesis. In the presence of H-ZSM-5h, 1-(2,4-dimethylquinolin-3-yl)ethanone (1a) and 3,4-dihydro-3,3,9-trimethyl-1(2H)-acridinone (1b) were produced in 82 and 93% yields, respectively.

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18

Ahmed, M. Glasuddin, UKR Romman, Kawsari Akhter, Monarul Islam, Mohammad Mosharrag Hossain, and Md Ershad Halim. "A Convenient Synthesis of Substituted Spiro[5.5]Undecanes Using Lewis Acid Catalysts." Dhaka University Journal of Science 60, no. 1 (2012): 121–24. http://dx.doi.org/10.3329/dujs.v60i1.10349.

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A one-pot synthesis of 3, 3-Dimethyl-7, 11-diphenyl-spiro [5, 5] undecane-1, 5, 9-triones 4a-c has been achieved by the application of Michael reaction between dimedone (5,5-dimethylcyclohexane-1,3-dione) 1 and trans,trans diarylideneacetones [1,5-diaryl-1,4- pentadien-3-ones] 2a-c (a. Ar = C6H5-, b. Ar = 2-Cl-C6H4-, c. Ar = 2- CH3O- C6H4) using Lewis acid catalysts.DOI: http://dx.doi.org/10.3329/dujs.v60i1.10349 Dhaka Univ. J. Sci. 60(1): 121-124 2012 (January)

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19

Abdolmohammadi, Shahrzad, Mahdieh Mohammadnejad, and Faezeh Shafaei. "TiO2 Nanoparticles as an Efficient Catalyst for the One-pot Preparation of Tetrahydrobenzo[c]acridines in Aqueous Media." Zeitschrift für Naturforschung B 68, no. 4 (2013): 362–66. http://dx.doi.org/10.5560/znb.2013-2323.

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A series of tetrahydrobenzo[c]acridinone derivatives have been prepared by a one-pot fourcomponent reaction of 1-naphthol, aromatic aldehydes, dimedone, and ammonium acetate in aqueous media using a catalytic amount of titanium dioxide nanoparticles (TiO2 NPs). The advantages of this novel protocol include the excellent yields, operational simplicity, short reaction time, easy work-up, reusability of the catalyst and an environmentally friendly procedure.

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20

Lalitha, Appaswami, Nangagoundan Vinoth, and Pullar Vadivel. "Expedient Synthesis and Antibacterial Activity of Tetrahydro-1′H-spiro[indoline-3,4′-quinoline]-3′-carbonitrile Derivatives Using Piperidine as Catalyst." Synlett 32, no. 07 (2021): 708–12. http://dx.doi.org/10.1055/s-0040-1706682.

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AbstractA convenient synthesis of 2′-amino-7′,7′-dimethyl-2,5′-dioxo-1′-(phenylamino)-5′,6′,7′,8′-tetrahydro-1′H-spiro[indoline-3,4′-quinoline]-3′-carbonitrile derivatives has been designed using different substituted isatins, various 5,5-dimethyl-3-(2-phenylhydrazinyl)cyclohex-2-enones (arylhydrazones of dimedone) and malononitrile in ethanol with piperidine as catalyst at room temperature. The structures of the synthesized compounds have been elucidated by various spectroscopic techniques. The selected compounds have also been evaluated for their antibacterial activities against human pathogenic bacteria.

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21

Türker, Lemi, and Erdem Dura. "A queer product of the Beirut reaction with dimedone-AM1 analysis." Journal of Molecular Structure: THEOCHEM 593, no. 1-3 (2002): 143–47. http://dx.doi.org/10.1016/s0166-1280(02)00311-1.

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22

Heydari, Reza, Rohollah Rahimi, Mehrnoosh Kangani, Afshin Yazdani-Elah-Abadi, and Mojtaba Lashkari. "K2CO3: A Mild and Efficient Catalyst for the Synthesis of Pyran Annulated Heterocyclic Systems by Grinding Method Under Solvent-Free Conditions." Acta Chemica Iasi 25, no. 2 (2017): 163–78. http://dx.doi.org/10.1515/achi-2017-0014.

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Abstract The potassium carbonate was applied as a green and efficient catalyst for the one-pot synthesis of pyran annulated heterocyclic systems, via the condensation between aromatic aldehydes, malononitrile and dimedone/1-naphtole by a grinding method at room temperature and solvent-free conditions. Short reaction times, environmentally friendly procedure and excellent yields are the main advantages of this procedure which makes it more economic than other environmentally synthetic methods.

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23

D, BHASKAR REDDY, PADMAJA A., and PADMAVATHI V. "Synthesis and Antimicrobial Activity of some Enamino Ketones and Esters of Bis(2-pyrazolyl)ketones and sulphones." Journal of Indian Chemical Society Vol. 71, May 1994 (1994): 259–62. https://doi.org/10.5281/zenodo.5894756.

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Department of Chemistry, Sn Venkateswara Umversity. Tirupati-517 502 <em>Manusmpt received 12 May 1993, accepted 28 June 1993</em> The enamino ketones and esters (2-5) have been obtained by the condensation of bis(4-aryl-2-pyrazolin-3-yl)- ketones and sulphones (1) with acetylacetone, dimedone and methyl/ethyl acetoacetate. Their spectra have been correlated to their structures. The antimicrobial activity of the compounds have also been assayed.

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24

Barakat, Assem, Abdullah M. Al-Majid, Mohammad Shahidul Islam, et al. "Molecular structure investigation and biological evaluation of Michael adducts derived from dimedone." Research on Chemical Intermediates 42, no. 5 (2015): 4041–53. http://dx.doi.org/10.1007/s11164-015-2257-1.

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25

Sayahi, Mohammad Hosein, Mahtab Yadollahi, Samir M. Hamad, et al. "Bi Metal–Organic Framework (Ce/Ni–BTC) as Heterogeneous Catalyst for the Green Synthesis of Substituted Chromeno[4, 3–b]quinolone under Solvent Free Condition." Current Organic Synthesis 18, no. 5 (2021): 475–82. http://dx.doi.org/10.2174/1570179418666210122100240.

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Aims: Novel bi metal organic framework (b–MOF) is synthesized and used as a heterogeneous catalyst for the synthesis of chromeno[4, 3–b]quinolone derivatives via one-pot and solvent-free, four-component reaction of dimedone, aromatic aldehydes, 4–hydroxycoumarin and ammonium acetate at 110°C. Background: b–MOFs can be used as a heterogeneous catalyst in the synthesis of many organic compounds. The active and multi-purpose sites in b–MOFs provide a varied function in their catalytic applications. In this paper, reductive CES method is applied for the synthesis of Ce0.47/Ni0.53–BTC b–MOF. The resulting b–MOF was used as a heterogeneous catalyst for the synthesis of chromeno[4, 3–b]quinolone via one-pot and solvent-free, fourcomponent reaction of dimedone, aromatic aldehyde, 4–hydroxycoumarin and ammonium acetate at 110 °C. Methods: Ce0.47/Ni0.53–BTC was synthesized in an electrochemical cell composed of a stainless steel foil with a size of 5cm×5cm centered between two 5cm×5cm sized graphite plates as the anodes by the cathodic current density of 0.2 A/dm2 and placed in a solution of cerium nitrate (0.3 g), nickel nitrate (0.3 g), H3BTC (0.2 g) and NaNO3 (0.1 g) in ethanol (500 mL). Ce0.47/Ni0.53–BTC (10 mg) was added to a mixture of dimedone (1 mmol), aromatic aldehyde (1 mmol), hydroxycoumarin (1 mmol) and ammonium acetate (1.5 mmol) and stirred at 110 °C under solvent-free conditions for 45 min. The reaction evolution was controlled by the TLC (hexane:ethyl acetate, 4:1). Then, boiling ethanol was added to the reaction mixture and stirred at room temperature for 15 min. After the reaction completion, the catalyst was separated by centrifuge. Finally, the reaction mixture was placed in an ice bath, which resulted in a white solid product and recrystallized from ethanol to give the pure product. Result: The b–MOF catalyst showed very good efficiency in the synthesis of the desired compounds and can be easily recovered by centrifuge and reused at least five times without a decrease in catalytic activity. Conclusion: In this report, a novel bi metal-organic framework (Ce0.47/Ni0.53–BTC) is synthesized via the cathodic electrosynthesis method. The synthesized b–MOF is fully characterized by several characterization methods. The catalytic activity of Ce0.47/Ni0.53–BTC is investigated in the synthesis of chromeno[4, 3–b]quinolone derivatives via one-pot four-component reaction of dimedone, aromatic aldehyde, 4–hydroxycoumarin and ammonium acetate. The reaction optimization results showed that the highest isolated yield was obtained when the reaction was performed in solvent-free conditions at 110 °C. The catalyst showed to be highly efficient in the synthesis of the desired compounds and performing the reaction utilizing various starting materials gave the products in good isolated yields, which proves the generality and the scope of the method. The catalyst could easily be recovered by centrifuge and reused at least five times without a decrease in catalytic activity.

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Zeynizadeh, Behzad, Soleiman Rahmani, and Arezu Hallaj. "The Immobilized Copper on Nickel Ferrite: A Magnetically Superior Nanocatalyst for Chemoselective and Knoevenagel Synthesis of Bisdimedones and 1,8-Dioxo-octahydroxanthenes under Solvent-Free Conditions." Current Organic Synthesis 16, no. 6 (2019): 939–47. http://dx.doi.org/10.2174/1570179416666190423123915.

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Aim and Objective: Nowadays, bisdimedones and 1,8-dioxo-octahydroxanthenes are considered as biologically active materials. Due to this, the synthesis of the mentioned materials is the subject of more interest. Although most of the reported methods have their own merits, however, they generally require the use of expensive reagents, hazardous organic solvents, a tedious workup procedure and reduced recyclability of the applied catalyst system. Overcoming of the above mentioned drawbacks, therefore, encouraged us to investigate the capability of nanostructured NiFe2O4@Cu towards the synthesis of bisdimedones and 1,8- dioxo-octahydroxanthenes under green reaction conditions. Materials and Methods: Nanoparticles of NiFe2O4@Cu were prepared via a two-step procedure including the preparation of NiFe2O4 by solid-state grinding of Ni(OAc)2·4H2O and Fe(NO3)3·9H2O in the presence of NaOH followed by the immobilization of Cu(0) on the surface of NiFe2O4 nucleus via hydrazine hydrate reduction of Cu(NO3)2·3H2O. Results: After the synthesis of NiFe2O4@Cu, the catalytic activity of the Cu-nanocatalyst towards Knoevenagel reaction of aromatic aldehydes with dimedone under different reaction conditions was investigated. The examinations showed that using the molar equivalents of aromatic aldehydes (1 mmol) and dimedone (2 mmol) in the presence of 0.15 g NiFe2O4@Cu under solvent-free conditions chemoselectively afforded structurally different bisdimedone products at 60°C and 1,8-dioxo-octahydroxanthenes at 120°C. Conclusion: In this study, magnetically, nanoparticles of NiFe2O4@Cu were prepared and then characterized using different analyses. The catalytic activity of the prepared Cu-nanocatalyst was also studied towards solvent-free Knoevenagel condensation of aromatic aldehydes with dimedone. All the reactions were carried out within 15-240 min to afford bisdimedone and 1,8-dioxo-octahydroxanthene products in high yields.

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Zare, Abdolkarim, Mohammad Mokhlesi, Alireza Hasaninejad, and Tahereh Hekmat-Zadeh. "Solvent-Free Synthesis of 1,8-Dioxo-octahydroxanthenes and 14-Aryl-14H-dibenzo[a,j]xanthenes using Saccharin Sulfonic Acid as an Efficient and Green Catalyst." E-Journal of Chemistry 9, no. 4 (2012): 1854–63. http://dx.doi.org/10.1155/2012/596862.

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Saccharin sulfonic acid (SaSA) is utilized as a highly efficient, green and inexpensive sulfonic acid-containing catalyst for the following one-pot multi-component organic transformations: (i) the condensation of dimedone (2 eq.) with aromatic aldehydes (1 eq.) leading to 1,8-dioxo-octahydroxanthenes, and (ii) the reaction of 2-naphthol (2 eq.) with arylaldehydes (1 eq.) leading to 14-aryl-14H-dibenzo[a,j]xanthenes. In these protocols, the title compounds are produced in high to excellent yields and in relatively short reaction times under solvent-free conditions.

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Abutalebi, Ali, Mohammad H. Mosslemin, and Razieh Mohebat. "Synthesis of functionalized trans-2,3-disubstituted-hexahydrobenzofurans in an aqueous medium using triethanolamine as catalyst." Journal of Chemical Research 43, no. 1-2 (2019): 39–42. http://dx.doi.org/10.1177/1747519819836524.

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A one-pot, efficient synthesis of seven novel trans-2,3-diacylated hexahydrobenzofuran derivatives has been achieved via a three-component condensation of N-(1-benzyloxycarbonylmethyl)quinolinium bromide with 5,5-dimethyl-1,3-cyclohexanedione (dimedone) and an aromatic aldehyde in the presence of catalytic amounts of triethanolamine in water under reflux conditions. The attractive features of the method are excellent yields and high purity, short reaction times, easy work-up, and use of an inexpensive and non-toxic catalyst.

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Hossain, MM, ME Halim, MM Islam, et al. "Michael 1:1 adducts by acid catalyzed reaction during synthesis of spiro and spiroketal compounds." Bangladesh Journal of Scientific and Industrial Research 55, no. 4 (2020): 283–88. http://dx.doi.org/10.3329/bjsir.v55i4.50967.

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Four Michael 1:1 adducts 2-[1,5-bis-(2-methoxyphenyl)-3-oxo-pent-4-enyl]-cyclohexane-1,3- dione 3a, 2-[1,5-bis-(2-methylphenyl)-3-oxo-pent-4-enyl]-cyclohexane-1,3-dione 3b, 2-[1,5-bis- (2-chlorophenyl)-3-oxo-pent-4-enyl]-cyclohexane-1, 3-dione 3c and 2-[1,5-Bis-(2-chloro- phenyl)- 3-oxo-pent-4-enyl]-5,5-dimethyl-cyclohexane-1,3-dione 3d have been synthesised by the application of Michael reaction between 1, 3-cyclohexanedione 1a or dimedone (5, 5-dimethylcy clohexane-1, 3-dione) 1b and trans,trans diarylideneacetone [1,5-diaryl-1,4-pentadien-3-one] 2a-c using acid catalyst. These adducts may be regarded as the intermediate of spiro [5.5] undecane compounds which can be achieved effectively via intramolecular cyclization of the Michael 1:1 adduct. The structures of the Michael 1:1 adducts 3a-d were determined by their UV, IR, 1H-NMR, 13C-NMR, DEPT-135 spectral data, HRMS and elemental analyses. Bangladesh J. Sci. Ind. Res.55(4), 283-288, 2020

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Aute, Dilip, Amol Parhad, Vitthal Vikhe, Bhagwat Uphad, and Anil Gadhave. "Aluminized polyborate catalyzed efficient solvent-free synthesis of 1,8-dioxo-decahydroacridines via hantzsch condensation." Current Chemistry Letters 13, no. 2 (2024): 417–24. http://dx.doi.org/10.5267/j.ccl.2023.10.004.

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In this work we report, aluminized polyborate catalyzed facile and efficient one-pot four component Hantzsch synthesis of 1,8-dioxo-decahydroacridines using substituted aromatic aldehydes (1 mmol), dimedone (2 mmol) and ammonium acetate (1.5 mmol) at 95-100oC under solvent-free condition. The prominent advantages of this methodology are good product yields (85-95%), eco-friendliness, mild reaction conditions and use of inexpensive catalyst. The structures of the targeted molecules were examined by FT-IR, 1H-NMR and mass spectral techniques.

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31

Wibaut, J. P., and H. P. L. Gitsels. "On the formation of 3, 3-dimethylcyclohexanol-1 and of 1, 1-dimethylcyclohexane on catalytic reduction of 1, 1-dimethylcyclohexanedione-3, 5 (dimedone)." Recueil des Travaux Chimiques des Pays-Bas 60, no. 8 (2010): 577–80. http://dx.doi.org/10.1002/recl.19410600802.

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Jazi, Niloofar, Samieh Fozooni, and Hooshang Hamidian. "One-pot, Multicomponent Synthesis under Microwave Conditions of New Imidazole and Acridine Benzamido Acetic Acid Derivatives." Journal of Chemical Research 42, no. 2 (2018): 80–85. http://dx.doi.org/10.3184/174751918x15181752711035.

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Starting from 4-aminohippuric acid (AHA), two novel series of heterocyclic compounds of pharmaceutical interest have been synthesised by one-pot, multicomponent reactions under microwave conditions. Reaction of AHA with various aldehydes and benzil in (1:1) EtOH/acetic acid in the presence of ammonium acetate yielded 1,2,3,5-tetra-arylated imidazole derivatives, whereas a solvent-free reaction of AHA with various aldehydes and dimedone (2 equiv.) in the presence of p-TSA yielded 4,9-diarylated 1,8-dioxo-decahydroacridine derivatives. These reactions produced good yields in short reaction times with an easy work-up, and purification of products was achieved by simple recrystallisation.

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Maqsood Ahmed, Quadri, Abdul Ahad Abdul Ahad, and Maqdoom Farooqui. "An Efficient multicomponenet synthesis of Tetrahydrobenzo Pyrans." International Journal of Pharmaceutical Research and Applications 09, no. 06 (2024): 1030–33. https://doi.org/10.35629/4494-090610301033.

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The one-pot, three-component tandem Knoevenagel–cyclocondensation reaction of dimedone malononitrile and different aldehydes was catalyzed by sodium oxalte for the first time in this work. After being heated at a temperature 50oC in EtOH:wate (1:1), these compounds underwent cyclization, yielding the corresponding tetrahydrobenzo[b]pyrans that are useful to medicininal field. Because the developed method doesn't require specialist equipment like microwaves, or ultrasounds, etc the approach is adaptable and convenient. Green reaction conditions, the use of commercially available catalyst, easy workup, and comparatively shorter reaction periods are also noteworthy aspects of this high-yielding protocol.

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Ali M., Feryal, та Alyaa S.M.O. Al-barwari. "Divalent transition metal complexes with mixed of β-enaminone and N,O-donor ligands: synthesis, characterization and biological assessment". Bulletin of the Chemical Society of Ethiopia 39, № 1 (2024): 65–78. http://dx.doi.org/10.4314/bcse.v39i1.5.

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This study extensively describes the synthesizing and characterizing of new β-enaminone complexes derived from dimedone and amines coordinated with transition metals Fe(II), Co(II), Ni(II), and Cu(II), also two ligand's metformin (Met) and 8-hydroxyquinoline (8-hq). These were determined via FT-IR, 1H-NMR, electron and mass spectroscopy, molar electrical conductivity, thermal analysis (TGA, DTA and DSC) and characterized by metal content determination (%), magnetic susceptibility and elemental analysis (C.H.N.) and SEM technique. The measurements indicate that the complexes have six coordination numbers, where the β-enaminone is coordinated as tetradentate ligand through the two nitrogen atoms and the two oxygen atoms beside metformin is coordinated through the two nitrogen atoms and 8-hydroxyquinoline is coordinated by oxygen and nitrogen atoms as bidentate ligands. The conductance suggests that all complexes have electrolytic behavior, being conductive in a ratio of (1:2). SEM results revealed the presence of nanostructures on sample surfaces. The biological activity of the prepared ligands and complexes are studied in different concentrations for four types of bacteria Staphylococcus aureus has (+G) and Escherichia coli, Pseudomonas aeruginosa, Klebsiella have (-G), well as, the influence of the fungus. The ligands have disparate effectiveness while complexes have high effectiveness inhibiting the bacteria and fungus. KEY WORDS: Mixed ligand systems, Dimedone, β-Enaminone ligands, Transition metals, Biological application Bull. Chem. Soc. Ethiop. 2025, 39(1), 65-78. DOI: https://dx.doi.org/10.4314/bcse.v39i1.5

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Lyadov, V. A., E. S. Denislamova, and A. N. Maslivets. "Spiro Heterocyclization of 1-Antipyryl-4-aroyl-5-methoxycarbonyl-1H-pyrrole-2,3-diones with Dimedone." Russian Journal of Organic Chemistry 61, no. 3 (2025): 558–60. https://doi.org/10.1134/s1070428023602650.

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Singh, D. P., Parveen, Ramesh Kumar, P. Surain, and K. R. Aneja. "Spectroscopic and antimicrobial studies of macrocyclic metal complexes derived from 1,8-diaminonaphthalene and dimedone." Journal of Inclusion Phenomena and Macrocyclic Chemistry 78, no. 1-4 (2013): 363–69. http://dx.doi.org/10.1007/s10847-013-0306-1.

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37

M, Heravi; Majid, M. Daraie, N. Lotfian, and M. Mirzaei. "Chemoselective synthesis of drug-like pyrrolo[2,3,4-kl]acridin-1-one using polyoxometalate@lanthanoid catalyst." Reaction Kinetics, Mechanisms and Catalysis 129, no. 1 (2020): 391–401. https://doi.org/10.1007/s11144-019-01709-3.

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The incorporation of polyoxometalates (POMs) or metal oxides into the metal–organic frameworks opens new research avenues for the synthesis of heterogeneous catalysts. In this project, a catalytic system based on neodymium clusters and Keggin-type of heteropoly acid (HPA) (Na[Nd(pydc-OH)(H<sub>2</sub>O)<sub>4</sub>]<sub>3</sub>}[SiW<sub>12</sub>O<sub>40</sub>]) was used as heterogeneous catalyst for one pot synthesis of pyrroloacridines, via multi component reactions involving dimedone, isatin and aniline in green condition. The novelty of this work originates from using inorganic–organic hybrids based upon POMs in catalyzing organic transformation. Compared with parent HPA (89.0% yield in 15 min for [SiW<sub>12</sub>O<sub>40</sub>]<sup>4−</sup>), this hybrid catalyst showed higher catalytic activity (94% yield in 8 min) in pyrroloacridines synthesis. The hybrid compound could be reused at least five times without obvious loss of the catalytic activity.

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Krishnan, Revathy, and Lalitha Appaswami. "CAN catalyzed synthesis of 1H-indazolotriones." Journal of Indian Chemical Society Vol. 92, Jun 2015 (2015): 857–59. https://doi.org/10.5281/zenodo.5636308.

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Department of Chemistry, Periyar University, Salem-636 011, Tamilnadu, India <em>E-mail</em> : lalitha2531@yahoo.co.in We have developed a potential method for the synthesis of biologically active<sup>1</sup> 2,2´-dimethyl-13-phenyl-2,3- dihydro-1<em>H</em>-indazolo[2,1-<em>b</em>]phthalazine-1,6,11(13<em>H</em>)-trione and its derivatives via an one-pot, four-component synthesis of phthalic anhydride, hydrazine, aromatic aldehydes and dimedone in the presence of ceric ammonium nitrate (CAN) at room temperature. The reaction was completed within 30 min yielding 70–90% of the corresponding product. The reaction was extended to different aldehydes and anhydrides leading to good yields in all the cases.

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Elinson, Michail N., Olga O. Sokolova, Ruslan F. Nasybullin, Tatiana A. Zaimovskaya, and Mikhail P. Egorov. "Efficient non-catalytic synthesis of substituted 2,3,4,9-tetrahydro-1H-xanthen-1-ones from salicylaldehydes and dimedone." Mendeleev Communications 25, no. 1 (2015): 19–20. http://dx.doi.org/10.1016/j.mencom.2015.01.006.

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Hou, Fang, Wei Zheng, and Nasser Yousefi. "Design, Characterization and Application of The SCMNPs@PC/VB1-Zn as A Green and Recyclable Biocatalyst for Synthesis of Pyrano[2,3-c]pyrazole and 4H-benzo-[b]-pyran Derivatives." Bulletin of Chemical Reaction Engineering & Catalysis 15, no. 1 (2020): 199–212. http://dx.doi.org/10.9767/bcrec.15.1.6179.199-212.

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Eco-friendly and reusable solid acid catalysts (SCMNPs@PC/VB1-Zn) were identified as one of the most effective basic catalysts for the composition of a pot, three-component pyrano[2,3-c]pyrazoles. Methyl-1-phenyl-1H-pyrazole-5(4H)-one, benzaldehyde and malononitrile in high yield at 80 °C. SCMNPs@ PC/VB1-Zn reports the simple and efficient catalysis of a three-component pot reaction of dimedone, aldehydes, and malononitrile to 4H-benzo-[b]-pyran derivatives. This magnetic nanocatalyst can be recycled more than 6 times without dramatically reducing performance with respect to reaction time and efficiency. Copyright © 2020 BCREC Group. All rights reserved

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41

El Ashry, El Sayed H., Laila Fathy Awad, Mohamed Nabil Abd Al Moaty, and Omayma Kh Bdeewy. "A novel trans-amination process in 3-arylamino- 5,5-dimethylcyclohex-2-en-1-one with nucleophiles and antimicrobial activity of selected products." Mediterranean Journal of Chemistry 7, no. 6 (2019): 452–62. http://dx.doi.org/10.13171/mjc7619019140eshea.

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Reaction of dimedone with arylamines afforded the respective enaminones. Some N-acetyl derivatives were prepared. The reaction of enaminones with hydroxylamine was found to be dependent on the nature of the arylamine moiety and the molar ratio of hydroxylamine to give the mono-, di- or tri-oximes. Cyclization of the trioxime by acetic anhydride gave dihydrobenzo[c][1,2,5]oxadiazol-4(5H)-one-5-O-acetyloxime. Coupling of the synthesized enaminones with benzene diazonium chloride gave 2,4-bis-phenylhydrazones or a mixture of 2-mono hydrazones and bis-hydrazones depending on the nature of the arylamine moiety. Trans-amination of the arylamine of the bis hydrazones with hydroxylamine gave the same1,3-bis oxime derivative. The structures of the synthesized compounds were confirmed by IR, 1HNMR, 13C NMR spectra. The antimicrobial activity of some selected products showed promising results.

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Reddy, M. Upendar, M. C. Somasekhara Reddy, and Venu Chakravartula. "Synthesis and Anti-Bacterial Activity of 1, 4-Dihydropyridine Derivatives Embedded with Chromone and Dimedone Based Hybrids." Asian Journal of Research in Chemistry 11, no. 1 (2018): 55. http://dx.doi.org/10.5958/0974-4150.2018.00012.3.

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El-Shaieb, Kamal M., Mohamed A. Ameen, Fathy F. Abdel-Latif, and Asmaa H. Mohamed. "Condensation Reactions of 2-Aminobenzohydrazide with Various Carbonyl Compounds." Zeitschrift für Naturforschung B 67, no. 11 (2012): 1144–50. http://dx.doi.org/10.5560/znb.2012-0202.

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Technical iodine was found to catalyze the condensation between 2-aminobenzohydrazide (1) and some aldehydes and ketones in absolute ethanol under mild conditions to afford hydrazone and quinazoline derivatives, respectively. Condensation of 1with terephthalaldehyde (2) in 1 : 1 molar ratios afforded the hydrazone 3, while hydrazone 4was formed on using a double molar ratio of 1. On the other hand, compound 1condensed with 4-formyl [2.2]paracyclophane (5) to give the hydrazone 6. However, spiro-quinazolines 8, 10, 12, and 14 were formed when compound 1reacted with ketones such as N-benzylpiperidone (7), indane-1,2,3-trione (9), cyclohexane-1,2-dione (11), and dimedone (13), respectively. Treatment of 1with tetrabromophthalic anhydride (TBPA, 18) and pyromellitic dianhydride (PMDA, 20) furnished phthalazino-quinazoline 19 and 21, respectively. The products were fully characterized according to their spectral analyses. The mechanisms of formation of the products have been rationalized.

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Sudarshan, Das, Kumar Kundu Shrishnu, Hajra Alakananda, and Majee Adinath. "Use of Zwitterionic-type molten salt at room temperature for the one-pot synthesis of N-substituted decahydroacridine-1,8-diones in aqueous-ethanol." Journal of Indian Chemical Society 93, Oct 2016 (2016): 1221–24. https://doi.org/10.5281/zenodo.5639375.

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Department of Chemistry, Visva-Bharati (A Central University), Santiniketan-731 235, West Bengal, India <em>E-mail </em>: adinath.majee@visva-bharati.ac.in, alakananda.hajra@visva-bharati.ac.in <em>Fax</em> : 91-3463-262728 Jhargram Raj College, Jhargram, Paschim Medinipur-721 507, West Bengal, India <em>Manuscript received online 21 August 2012, accepted 09 June 2016</em> Zwitterionic-type molten salt – 4-(1-imidazolium) butane sulfonate acts as an excellent catalyst for the synthesis of N-substituted decahydroacridine-1,8-diones through condensation of dimedone, aromatic aldehyde and amine via multicomponent condensation strategy in aqueous-ethanol as solvent. The key advantages of this process are high yields, roomtemperature reaction, reusability of catalyst, environmental friendliness, easy work-up and purification of products by non-chromatographic methods.

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45

Elinson, Michail N., Olga O. Sokolova, Ruslan F. Nasybullin, Tatiana A. Zaimovskaya, and Mikhail P. Egorov. "ChemInform Abstract: Efficient Non-Catalytic Synthesis of Substituted 2,3,4,9-Tetrahydro-1H-xanthen-1-ones from Salicylaldehydes and Dimedone." ChemInform 46, no. 24 (2015): no. http://dx.doi.org/10.1002/chin.201524167.

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46

Fekri, Leila Z. "NiFe2O4@SiO2 @amino Glucose Magnetic Nanoparticle under Solvent-free Condition: A New, mild, Simple and Effective Avenue for the Synthesis of Quinazolinone, Imidazo[1,2-a]Pyrimidinone and Novel Derivatives of Amides." Current Organic Synthesis 17, no. 4 (2020): 304–12. http://dx.doi.org/10.2174/1570179417666200409151330.

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Background: Imidazo[1,2-a]pyrimidinone, quinazolinone and amide derivatives have attracted a lot of interest because of their broad scope of biological and pharmacological activities. There are a lot of methods reported in the literature for their synthesis. Therefore, we became interested in developing a convenient synthetic method for the preparation of imidazoquinazolinone and amide derivatives. Objective: NiFe2O4@SiO2 @glucose amine were synthesized, characterized and have been used for the green, effective and mild multicomponent synthesis of quinazolinones, benzoimidazo[1,2-a]pyrimidinones and amides under solvent-free conditions in short reaction times and excellent yields. To expand of the scope of this avenue, multicomponent synthesis of mono and bis novel amides was tested for the first time. All of the products were characterized by mp, FT-IR, NMR and elemental analysis. Methods: Aldehyde (1mmol), 2-amino benzimidazole (1 mmol), dimedone (1mmol) or indane-1,3-dione (1 mmol) for the synthesis of quinazoline or imidazopyrimidinones and arene (1mmol), anhydride (1mmol), 2- aminobenzimidazole (1mmol) for the synthesis of amides in the nanocatalyst NiFe2O4@SiO2@glucose amine (0.15mol%: 0.05g) were stirred by a magnet for the required reaction time. After completion of the reaction, as indicated by TLC, the products were collected and recrystallized from ethanol if necessary. Results: We present a novel avenue for the synthesis of benzimidazo[1,2-a] pyrimidinones, quinazolinones and amides in the presence of NiFe2O4@SiO2@glucose amine under solvent-free conditions. Conclusion: In conclusion, we developed NiFe2O4@SiO2 @glucose amine-catalysed multicomponent synthesis of quinazolinones and imidazo[1,2-a]pyrimidinones using the reaction of benzaldehyde, dimedone or indane-dione and 2-aminobenzimidazole and multicomponent synthesis of amides using arenes, cyclic anhydrides and 2-aminobenzimidazole by a solvent-free technique. This method proves to be a robust and innovative approach for the synthesis of a biologically important structure. The operational simplicity, the excellent yields of products, ease of separation and recyclability of the magnetic catalyst, waste reduction and high selectivity are the main advantages of this method. Furthermore, this new avenue is cheap and environmentally benign.

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Langarizadeh, Mohammad Amin, Khalil Eskandari, Ardavan Abiri, Marziye Ranjbar Tavakoli, Ali Asadipour, and Yaghoub Pourshojaei. "A novel dual three and five-component reactions between dimedone, aryl aldehydes, and 1-naphthylamine: synthesis and computational studies." Journal of Molecular Structure 1258 (June 2022): 132569. http://dx.doi.org/10.1016/j.molstruc.2022.132569.

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48

Chaudhary, R. P., Poonam Gautam, Deepika Gautam, and Isha Mittal. "Ultrasound assisted regioselective synthesis, photophysical and structural studies of 1-substituted indazol-4(5H)-ones and enaminodiketones of dimedone." Journal of Molecular Structure 1228 (March 2021): 129710. http://dx.doi.org/10.1016/j.molstruc.2020.129710.

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Mohareb, Rafat Milad, Fatma Mohamed Manhi, Mahmoud Ali Abdelaziz Mahmoud, and Amal Abdelwahab. "Uses of dimedone to synthesis pyrazole, isoxazole and thiophene derivatives with antiproliferative, tyrosine kinase and Pim-1 kinase inhibitions." Medicinal Chemistry Research 29, no. 8 (2020): 1536–51. http://dx.doi.org/10.1007/s00044-020-02579-4.

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Parekh, H. P., M. H. Chauhan, N. L. Solanki, and V. H. Shah. "A Clean, Benign, Energy Efficient One-Pot Multicomponent Synthesis and Bio-evaluation of Novel [1,2,4]Triazolo[1,5-a]quinolines." Asian Journal of Organic & Medicinal Chemistry 6, no. 2 (2021): 111–15. http://dx.doi.org/10.14233/ajomc.2021.ajomc-p322.

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In present work, a series of novel [1,2,4]triazolo[1,5-a]quinoline derivatives (HP-101-110) have been synthesized using multi-component reaction at room temperature in the presence of ammonium chloride as mild, cost effective green catalyst along with water as eco-friendly green solvent. The synthesis of 1,2,4-triazolo[1,5-a]quinolines (HP-101-110) was achieved by two step process. In first step, diversified Hantzsch pyridine reaction of an appropriate aromatic aldehyde, malononitrile, dimedone and benz hydrazide using ethanol as a solvent gives N-(2-amino-3-cyano-7,7-dimethyl-5-oxo-4-phenyl-5,6,7,8- tetrahydro-quinolin-1(4H)-yl)-4-hydroxybenzamide derivatives. In the second step, synthesis of the final product 2-(4-hydroxyphenyl)-8,8-dimethyl-6-oxo-5-phenyl-6,7,8,9-tetrahydro[1,2,4]triazolo[1,5- a]-quinoline-4-carbonitriles was achieved by the intramolecular cyclization of step 1 product.The structure of all the synthesized compounds (HP101-110) has been elucidated by FT-IR, 1H & 13C NMR, mass spectral data and elemental analyses.

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