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Journal articles on the topic 'Dimethoxycinnamic acid'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Rudyanto, Marcellino, and Lanny Hartanti. "SYNTHESIS OF SOME CINNAMIC ACID DERIVATIVES: EFFECT OF GROUPS ATTACHED ON AROMATIC RING TO THE REACTIVITY OF BENZALDEHYDE." Indonesian Journal of Chemistry 8, no. 2 (2010): 226–30. http://dx.doi.org/10.22146/ijc.21626.

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Synthesis of cinnamic acid and its six derivatives has been done by employing Knoevenagel reaction. Benzaldehyde, 4-butylbenzaldehyde, 4-t-butylbenzaldehyde, 4-butoxybenzaldehyde, 4-phenylbenzaldehyde, 5-bromo-2,4-dimethoxybenzaldehyde, and 5-bromo-2,3-dimethoxybenzaldehyde were reacted with malonic acid in pyridine – piperidine to give cinnamic acid (85,3%), 4-butylcinnamic acid (69,3%), 4-t-butylcinnamic acid (77,7%), 4-butoxycinnamic acid (64,5%), 4-phenylcinnamic acid (65,5%), 5-bromo-2,4-dimethoxycinnamic acid (53,2%) and 5-bromo-2,4-dimethoxycinnamic acid (57,2%), respectively. It was di

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2

Zheng, Ruirui, Jinyu Zhao, Li Ma, Xingtao Qie, Xizhong Yan, and Chi Hao. "Behavioral, Electrophysiological, and Toxicological Responses of Plutella xylostella to Extracts from Angelica pubescens." Insects 14, no. 7 (2023): 613. http://dx.doi.org/10.3390/insects14070613.

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Plutella xylostella L. is a destructive pest affecting cruciferous vegetables, causing massive economic losses worldwide. Plant−based insecticides are considered promising insect control agents. The Angelica pubescens extract inhibited female oviposition, with an oviposition deterrence index (ODI) of 61.65% at 12.5 mg/mL. We aimed to identify the bioactive compounds in A. pubescens extract. The compounds from A. pubescens extract were analyzed using LC−MS techniques. The toxicity and behavioral responses of larvae and adults of P. xylostella to ten compounds were investigated. We found that th

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3

Zanyatkin, Ivan, Yulia Stroylova, Sofia Tishina, et al. "Inhibition of Prion Propagation by 3,4-Dimethoxycinnamic Acid." Phytotherapy Research 31, no. 7 (2017): 1046–55. http://dx.doi.org/10.1002/ptr.5824.

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4

O'CONNELL, JOHN E., and PATRICK F. FOX. "Effects of phenolic compounds on the heat stability of milk and concentrated milk." Journal of Dairy Research 66, no. 3 (1999): 399–407. http://dx.doi.org/10.1017/s0022029999003593.

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A methanol extract of green tea was fractionated on Sephadex LH-20. The compounds eluted were identified by thin layer chromatography as catechin–epicatechin, gallocatechin, epigallocatechin, epicatechin gallate and epigallocatechin gallate. When added to milk at 2·0 g/l, these polyphenols, apart from the catechin–epicatechin mixture, increased the heat stability of skim milk, particularly in the region of the minimum (pH 6·8–7·1). When added at 0·4 g/l, green tea polyphenols also increased the heat stability of concentrated milk. The effects of other phenolic compounds on the heat stability o

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5

Chen, Chung-Yi, Yu-Ting Yeh, and Woei-Ling Yang. "Amides from the Stem of Capsicum annuum." Natural Product Communications 6, no. 2 (2011): 1934578X1100600. http://dx.doi.org/10.1177/1934578x1100600217.

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7′-(4′-hydroxyphenyl)- N-[(4-methoxyphenyl)ethyl]propenamide (1), 7′-(3′,4′-dihydroxyphenyl)- N-[(4-methoxyphenyl)ethyl]propenamide (2), N-p-trans-coumaroyltyramine (3), N-trans-caffeoyltyramine (4), β-sitostenone (5), ferulic acid (6), hydroferulic acid (7), 5-hydroxy-3,4-dimethoxycinnamic acid (8), veratic acid (9), vanillic acid (10), isovanillic acid (11), syringic acid (12), (+)-syringaresinol (13), and pheophorbide a (14) were isolated from the stems of Capsicum annuum (Solanaceae). Among them, 1 is a new amide compound. The structures of these compounds were characterized and identified

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6

Medvedeva, Maria, Natalia Kitsilovskaya, Yulia Stroylova, Irina Sevostyanova, Ali Akbar Saboury, and Vladimir Muronetz. "Hydroxycinnamic Acid Derivatives from Coffee Extracts Prevent Amyloid Transformation of Alpha-Synuclein." Biomedicines 10, no. 9 (2022): 2255. http://dx.doi.org/10.3390/biomedicines10092255.

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Earlier we showed that derivatives of hydroxycinnamic acids prevent amyloid transformation of alpha-synuclein and prion protein. The aim of this work was to determine the content of 3-hydroxycinnamic acid derivatives in coffee extracts and to evaluate their activity in relation to alpha-synuclein amyloid aggregation. Hydroxycinnamic acid derivatives were identified in aqueous and ethanol extracts of coffee beans by quantitative mass spectrometric analysis. Only 3,4-dimethoxycinnamic acid (13–53 μg/mL) was detected in significant amounts in the coffee extracts, while ferulic acid was present in

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7

Peterson, John R., Hoang D. Do, and Andrew J. Dunham. "Cerium(IV)-induced nitration of cinnamic acids. Novel remote electrophilic substitution." Canadian Journal of Chemistry 66, no. 7 (1988): 1670–74. http://dx.doi.org/10.1139/v88-271.

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The treatment of (E)-3,4-dimethoxycinnamic acid with ceric ammonium nitrate in trifluoroacetic acid afforded (E)-1,2-dimethoxy-4-nitro-5-(2-nitroethenyl)benzene in 79% yield. The unusual ipso substitution of the carboxylic acid moiety by a nitro functional center illustrated a new reaction manifold of cerium(IV). Six cinnamic acids were examined to ascertain the generality of the transformation. The bidentate nitrato structure of the metal salt is believed to account for the nitrating ability of this system.

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8

Sethuraman, Anand, Danny E. Akin, Jason G. Eisele, and Karl-Erik L. Eriksson. "Effect of aromatic compounds on growth and ligninolytic enzyme production of two white rot fungi Ceriporiopsis subvermispora and Cyathus stercoreus." Canadian Journal of Microbiology 44, no. 9 (1998): 872–85. http://dx.doi.org/10.1139/w98-077.

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Seven benzoic acid, ten cinnamic acid, and five benzaldehyde derivatives were tested for their effects on hyphal growth and production of laccase and manganese peroxidase by Ceriporiopsis subvermispora FP 90031-sp and Cyathus stercoreus ATCC 36910. Derivatives tested included phenolic compounds and their corresponding unsubstituted and O-methylated derivatives. Benzaldehyde derivatives were more toxic to both fungi than the corresponding benzoic and cinnamic acid derivatives. Hyphal growth was generally increased at a low concentration of 1 mM, while higher concentrations of 5-10 mM mostly res

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9

AVIJIT, BANERJl, JANA SUKLA, and RANABIR SUR KUMAR. "Reaction of Cinnamic Acid Derivatives with Sodium Naphthalenide, A Single-electron Transfer Reagent." Journal Of Indian Chemical Society Vol. 66, Aug-Oct 1989 (1989): 664–72. https://doi.org/10.5281/zenodo.6023992.

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Centre of Advanced Studies on Natural Products, Department of Chemistry University of Calcutta 92 Acharya Prafulla Chandra Road, Calcutta- 700 009 The reactions of the piperidides of cinnamic acid, <em>p</em>-methoxycinnamic acid and 3,4-dimethoxycinnamic acid with the single-electron transfer reagent sodium naphthalenide was investigated. Three products were obtained in each case-the corresponding dihydro- erivative and two diastereoisomeric piperidides of 3,4-diaryl- 1,6-hexanedioic acid resulting from reductive dimerisation. The <em>ß,ß'</em>- rather than  \(\

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10

Theodosis-Nobelos, Panagiotis, Georgios Papagiouvannis, and Eleni A. Rekka. "Ferulic, Sinapic, 3,4-Dimethoxycinnamic Acid and Indomethacin Derivatives with Antioxidant, Anti-Inflammatory and Hypolipidemic Functionality." Antioxidants 12, no. 7 (2023): 1436. http://dx.doi.org/10.3390/antiox12071436.

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A series of thiomorpholine and cinnamyl alcohol derivatives, conjugated with cinnamic acid-containing moieties, such as ferulic acid, sinapic acid and 3,4-dimethoxycinnamic acid, were synthesized and tested for their antioxidant, anti-inflammatory and hypolipidemic properties. An indomethacin ester with 2,6-di-tert-butyl-4-(hydroxymethyl)phenol was also prepared for reasons of comparison. The majority of the compounds demonstrated considerable antioxidant capacity and radical scavenging activity, reaching up to levels similar to the well-known antioxidant trolox. Some of them had an increased

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11

Zhou, Chunran, Jingbang Zhang, Yangliu Wu, et al. "Metabolomic Analysis on the Mechanism of Nanoselenium Biofortification Improving the Siraitia grosvenorii Nutritional and Health Value." Foods 11, no. 19 (2022): 3019. http://dx.doi.org/10.3390/foods11193019.

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Nanoselenium (nano-Se) foliar application is crucial for enhancing plant health. However, the mechanism by which nano-Se biofortification promotes the nutritional components of Siraitia grosvenorii remains unclear. In this study, nano-Se foliar application increased the carbohydrate and amino acid contents, including glucose (23.6%), fructose (39.7%), sucrose (60.6%), tryptophan (104.5%), glycine (85.9%), tyrosine (78.4%), phenylalanine (60.1%), glutamic acid (63.4%), and proline (52.5%). Nano-Se application enhanced apigenin (3.8 times), syringic acid (0.7 times), and 4-hydroxy-3,5-dimethoxyc

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12

Sha, Na, Hui-Lian Huang, Jin-Qiang Zhang, et al. "Simultaneous Quantification of Eight Major Bioactive Phenolic Compounds in Chinese Propolis by High-Performance Liquid Chromatography." Natural Product Communications 4, no. 6 (2009): 1934578X0900400. http://dx.doi.org/10.1177/1934578x0900400615.

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A simple, sensitive and specific high-performance liquid chromatography-UV (HPLC-UV) method has been developed to simultaneously quantify the eight major bioactive phenolic compounds in Chinese propolis, namely caffeic acid, isoferulic acid, 3,4-dimethoxycinnamic acid, pinobanksin 5-methyl ether, pinocembrin, benzyl caffeate, chrysin and galangin. This HPLC assay was performed on an Agilent Zorbax Extend-C18 (250 × 4.6 mm, 5 μm) column with a gradient of methanol and 0.2% aqueous acetic acid (v/v) in 50 min, at a flow rate of 1.0 mL/min, and detected at 290 nm. All calibration curves showed go

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13

Pekala, Karolina, Katarzyna Wawrzusiszyn, and Anna Bogucka-Kocka. "Phenolic substances in Ailanthus glandulosa Desf." Current Issues in Pharmacy and Medical Sciences 27, no. 2 (2014): 84–87. http://dx.doi.org/10.2478/cipms-2014-0019.

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Abstract The aim of this work was the isolation and identification of phenolic acids from fruit and leaves of Ailanthus glandulosa Desf. The methods used in the isolation and identification of the compounds were: isolation of phenolic acids modified by Ibrahim and Towers, acidic and alkaline hydrolysis by Schmidtlein and Herrmann and identification of phenolic acids in the isolated fraction of two-dimensional thin layer chromatography (TLC) on cellulose plates. In the course of the study, the presence of phenolic acids in leaves and fruit of Ailanthus glandulosa Desf was confirmed. Overall, pr

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14

Watanabe, Satoru, Shoichi Sato, Sumika Nagase, Kazuaki Shimosato, and Taiichi Saito. "Polyamine levels in various tissues of rats treated with 3-hydroxy-4-methoxycinnamic acid and 3,4-dimethoxycinnamic acid." Anti-Cancer Drugs 7, no. 8 (1996): 866–72. http://dx.doi.org/10.1097/00001813-199611000-00008.

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15

Xuan, Hongzhuan, Yuehua Wang, Aifeng Li, Chongluo Fu, Yuanjun Wang, and Wenjun Peng. "Bioactive Components of Chinese Propolis Water Extract on Antitumor Activity and Quality Control." Evidence-Based Complementary and Alternative Medicine 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/9641965.

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To understand the material basis of antitumor activity of Chinese propolis water extract (CPWE), we developed a simple and efficient method using macroporous absorptive resin coupled with preparative high performance liquid chromatography and separated and purified eleven chemical components (caffeic acid, ferulic acid, isoferulic acid, 3,4-dimethoxycinnamic acid, pinobanksin, caffeic acid benzyl ester, caffeic acid phenethyl ester, apigenin, pinocembrin, chrysin, and galangin) from CPWE; then we tested the antitumor activities of these eleven components using different human tumor cell lines

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16

Li, Yanqun, Wenping Ding, Jiajia Yin, et al. "2,3-Dimethoxycinnamic Acid from a Marine Actinomycete, a Promising Quorum Sensing Inhibitor in Chromobacterium violaceum." Marine Drugs 22, no. 4 (2024): 177. http://dx.doi.org/10.3390/md22040177.

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An ethyl acetate extract of a marine actinomycete strain, Nocardiopsis mentallicus SCSIO 53858, isolated from a deep-sea sediment sample in the South China Sea, exhibited anti-quorum-sensing (QS) activity against Chromobacterium violaceum CV026. Guided by the anti-QS activity, a novel active compound was isolated and purified from the extract and was identified as 2,3-dimethoxycinnamic acid (2,3-DCA) through spectral data analysis. At a concentration of 150 μg/mL, 2,3-DCA exhibited robust inhibitory effects on three QS-regulated traits of C. violaceum CV026: violacein production, swarming moti

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17

Monte, Manuel J. S., and Dorothea M. Hillesheim. "Vapour pressures, enthalpies and entropies of sublimation of trans -cinnamic acid and of nine methoxy and dimethoxycinnamic acids." Journal of Chemical Thermodynamics 31, no. 11 (1999): 1443–56. http://dx.doi.org/10.1006/jcht.1999.0540.

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18

Mostafa, Islam, Ehsan Abd El-Aziz, Samia Hafez, and Assem El-Shazly. "Chemical Constituents and Biological Activities of Galinsoga parvifl ora Cav. (Asteraceae) from Egypt." Zeitschrift für Naturforschung C 68, no. 7-8 (2013): 285–92. http://dx.doi.org/10.1515/znc-2013-7-805.

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The phytochemical investigation of an aqueous ethanolic extract of Galinsoga parviflora Cav. (Asteraceae) resulted in the isolation and identification of eleven compounds namely: triacontanol, phytol, β-sitosterol, stigmasterol, 7-hydroxy-β-sitosterol, 7-hydroxystigmasterol, β-sitosterol-3-O-β-D-glucoside, 3,4-dimethoxycinnamic acid, protocatechuic acid, fumaric acid, and uracil. Furthermore, 48 volatile constituents were identified in the hydrodistilled oil of the aerial parts. The ethanolic extract at a content of 400 mg/kg body weight (BW) exerted 87% reduction in the alanine aminotransfera

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19

Sun, Liping, Kai Wang, Xiang Xu, Miaomiao Ge, Yifan Chen, and Fuliang Hu. "Potential Protective Effects of Bioactive Constituents from Chinese Propolis against Acute Oxidative Stress Induced by Hydrogen Peroxide in Cardiac H9c2 Cells." Evidence-Based Complementary and Alternative Medicine 2017 (2017): 1–10. http://dx.doi.org/10.1155/2017/7074147.

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Chinese propolis (CP) is known as a health food but its beneficial effects in protecting cardiomyocytes remain elusive. Here, we investigated the effects of CP and its active compounds on hydrogen peroxide (H2O2) induced rats cardiomyocytes (H9c2) oxidative injury. Cell viability decreases induced by H2O2 were mitigated by different CP extracts using various solvents. From these active fractions, six active compounds were separated and identified. Among tested isolated compound, the cytoprotective activities of three caffeates, caffeic acid phenethyl ester (CAPE), benzyl caffeate (BZC), and ci

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20

Jiang, Xiasen, Linchen Tao, Chunguang Li, et al. "Grouping, Spectrum–Effect Relationship and Antioxidant Compounds of Chinese Propolis from Different Regions Using Multivariate Analyses and Off-Line Anti-DPPH Assay." Molecules 25, no. 14 (2020): 3243. http://dx.doi.org/10.3390/molecules25143243.

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49 samples of propolis from different regions in China were collected and analyzed for their chemical compositions, contents of total flavonoids (TFC), total phenolic acid (TPC) and antioxidant activity. High-performance liquid chromatography (HPLC) analysis identified 15 common components, including key marker compounds pinocembrin, 3-O-acetylpinobanksin, galangin, chrysin, benzyl p-coumarate, pinobanksin and caffeic acid phenethyl ester (CAPE). Cluster analysis (CA) and correlation coefficients (CC) analysis showed that these propolis could be divided into three distinct groups. Principal co

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21

Nouni, Christina, Panagiotis Theodosis-Nobelos, and Eleni A. Rekka. "Antioxidant and Hypolipidemic Activities of Cinnamic Acid Derivatives." Molecules 28, no. 18 (2023): 6732. http://dx.doi.org/10.3390/molecules28186732.

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Oxidative stress and hyperlipidemia are important factors for the initiation and progression of various cell degenerative pathological conditions, including cardiovascular and neurological diseases. A series of cinnamic acid-derived acids, such as ferulic acid, sinapic acid, 3,4-dimethoxycinnamic acid, p-coumaric acid, and (E)-3-(3,5-di-tert-butyl-4-hydroxyphenyl)acrylic acid, were esterified or amidated with various moieties, bearing different biological activities, and evaluated. The antioxidant and radical scavenging abilities of the compounds via inhibition of rat hepatic microsomal membra

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22

Farrell, Tracy L., Miren Gomez-Juaristi, Laure Poquet, et al. "Absorption of dimethoxycinnamic acid derivatives in vitro and pharmacokinetic profile in human plasma following coffee consumption." Molecular Nutrition & Food Research 56, no. 9 (2012): 1413–23. http://dx.doi.org/10.1002/mnfr.201200021.

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23

Yi, Shengxiang, Gaowei Zhang, Mingyan Liu, et al. "Citrus Honey Ameliorates Liver Disease and Restores Gut Microbiota in Alcohol–Feeding Mice." Nutrients 15, no. 5 (2023): 1078. http://dx.doi.org/10.3390/nu15051078.

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Citrus honey (CH) is rich in nutrients that have a wide variety of biological functions, such as antibacterial, anti–inflammatory, and antioxidant activities, and which demonstrate therapeutic properties, such as anti–cancer and wound–healing abilities. However, the effects of CH on alcohol–related liver disease (ALD) and the intestinal microbiota remain unknown. This study aimed to determine the alleviating effects of CH on ALD and its regulatory effects on the gut microbiota in mice. In total, 26 metabolites were identified and quantified in CH, and the results suggested that the primary met

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24

Rychlicka, Magdalena, Natalia Niezgoda, and Anna Gliszczyńska. "Development and Optimization of Lipase-Catalyzed Synthesis of Phospholipids Containing 3,4-Dimethoxycinnamic Acid by Response Surface Methodology." Catalysts 10, no. 5 (2020): 588. http://dx.doi.org/10.3390/catal10050588.

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The interesterification reaction of egg-yolk phosphatidylcholine (PC) with ethyl ester of 3,4-dimethoxycinnamic acid (E3,4DMCA) catalyzed by Novozym 435 in hexane as a reaction medium was shown to be an effective method for the synthesis of corresponding structured O-methylated phenophospholipids. The effects of substrate molar ratios, time of the reaction and enzyme load on the process of incorporation of 3,4DMCA into PC were evaluated by using the experimental factorial design of three factors and three levels. The results showed that a substrate molar ratio is a crucial variable for the max

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25

Andrade, P. B., R. Leitão, R. M. Seabra, M. B. Oliveira, and M. A. Ferreira. "3,4-Dimethoxycinnamic acid levels as a tool for differentiation of Coffea canephora var. robusta and Coffea arabica." Food Chemistry 61, no. 4 (1998): 511–14. http://dx.doi.org/10.1016/s0308-8146(97)00067-8.

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26

Mishra, Manish Kumar, Arijit Mukherjee, Upadrasta Ramamurty, and Gautam R. Desiraju. "Crystal chemistry and photomechanical behavior of 3,4-dimethoxycinnamic acid: correlation between maximum yield in the solid-state topochemical reaction and cooperative molecular motion." IUCrJ 2, no. 6 (2015): 653–60. http://dx.doi.org/10.1107/s2052252515017297.

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A new monoclinic polymorph, form II (P21/c,Z= 4), has been isolated for 3,4-dimethoxycinnamic acid (DMCA). Its solid-state 2 + 2 photoreaction to the corresponding α-truxillic acid is different from that of the first polymorph, the triclinic form I (P\bar 1,Z= 4) that was reported in 1984. The crystal structures of the two forms are rather different. The two polymorphs also exhibit different photomechanical properties. Form I exhibits photosalient behavior but this effect is absent in form II. These properties can be explained on the basis of the crystal packing in the two forms. The nanoinden

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27

Hutachok, Nuntouchaporn, Pimpisid Koonyosying, Tanachai Pankasemsuk, et al. "Chemical Analysis, Toxicity Study, and Free-Radical Scavenging and Iron-Binding Assays Involving Coffee (Coffea arabica) Extracts." Molecules 26, no. 14 (2021): 4169. http://dx.doi.org/10.3390/molecules26144169.

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We aimed to analyze the chemical compositions in Arabica coffee bean extracts, assess the relevant antioxidant and iron-chelating activities in coffee extracts and instant coffee, and evaluate the toxicity in roasted coffee. Coffee beans were extracted using boiling, drip-filtered and espresso brewing methods. Certain phenolics were investigated including trigonelline, caffeic acid and their derivatives, gallic acid, epicatechin, chlorogenic acid (CGA) and their derivatives, p-coumaroylquinic acid, p-coumaroyl glucoside, the rutin and syringic acid that exist in green and roasted coffee extrac

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28

Chen, Wenbin, Xijuan Tu, Dehui Wu, Zhaosheng Gao, Siyuan Wu, and Shaokang Huang. "Comparison of the Partition Efficiencies of Multiple Phenolic Compounds Contained in Propolis in Different Modes of Acetonitrile–Water-Based Homogenous Liquid–Liquid Extraction." Molecules 24, no. 3 (2019): 442. http://dx.doi.org/10.3390/molecules24030442.

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Homogeneous liquid–liquid extraction (HLLE) has attracted considerable interest in the sample preparation of multi-analyte analysis. In this study, HLLEs of multiple phenolic compounds in propolis, a polyphenol-enriched resinous substance collected by honeybees, were performed for improving the understanding of the differences in partition efficiencies in four acetonitrile–water-based HLLE methods, including salting-out assisted liquid–liquid extraction (SALLE), sugaring-out assisted liquid–liquid extraction (SULLE), hydrophobic-solvent assisted liquid–liquid extraction (HSLLE), and subzero-te

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29

Youssef, Nesrine H., Sameer H. Qari, Saleh Matar, et al. "Licorice, Doum, and Banana Peel Extracts Inhibit Aspergillus flavus Growth and Suppress Metabolic Pathway of Aflatoxin B1 Production." Agronomy 11, no. 8 (2021): 1587. http://dx.doi.org/10.3390/agronomy11081587.

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Three different concentrations of four (ethanol, acetone, methanol, and diethyl ether) extracts of licorice, doum, and banana peel were evaluated for antifungal and antimycotoxigenic efficiency against a maize aflatoxigenic fungus, Aspergillus flavus. Among them, the licorice diethyl ether 75% extract was intensely active, showing the best wet and dry weight inhibition and exhibiting the highest efficacy ratio (91%). Regarding aflatoxin B1 (AFB1) production, all the plant extracts tested were effective against AFB1 production after one month of maize storage, with average efficacy ratios rangi

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Hemaiswarya, Shanmugam, and Mukesh Doble. "Synergistic interaction of phenylpropanoids with antibiotics against bacteria." Journal of Medical Microbiology 59, no. 12 (2010): 1469–76. http://dx.doi.org/10.1099/jmm.0.022426-0.

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Phenylpropanoids constitute a large part of our daily diet and there is a possibility that they might interact with synthetic drugs. The present work was aimed at studying the interaction of seven phenylpropanoids (cinnamic, p-coumaric, caffeic, chlorogenic, ferulic, 3,4-dimethoxycinnamic and 2,4,5-trimethoxycinnamic acid) with five antibiotics (amikacin, ampicillin, ciprofloxacin, erythromycin and vancomycin) against Gram-negative (Escherichia coli, Enterobacter aerogenes and Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacteria. The interaction studies were performed by

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31

Desiraju, Gautam R., and Cheedella V. K. M. Sharma. "C–H ⋯ O hydrogen bonding and topochemistry in crystalline 3,5-dinitrocinnamic acid and its 1 : 1 donor–acceptor complex with 2,5-dimethoxycinnamic acid." J. Chem. Soc., Chem. Commun., no. 18 (1991): 1239–41. http://dx.doi.org/10.1039/c39910001239.

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Battaglia, Luigi Pietro, Anna Bonamartini Corradi, Maria Antonietta Zoroddu, Gavina Manca, Riccardo Basosi, and Costantino Solinas. "Synthesis, spectroscopic and X-ray structural characterization of ternary complexes of copper(II) and 2,5-dimethoxycinnamic acid with phenanthrolines." Journal of the Chemical Society, Dalton Transactions, no. 8 (1991): 2109. http://dx.doi.org/10.1039/dt9910002109.

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33

Sarma, Jagarlapudi A. R. P., and Gautam R. Desiraju. "The novel 1 : 1 donor–acceptor complex, 3,4-dimethoxycinnamic acid–2,4-dinitrocinnamic acid. Crystal engineering, structure, and anomalous lack of solid-state topochemical reactivity." J. Chem. Soc., Perkin Trans. 2, no. 12 (1985): 1905–12. http://dx.doi.org/10.1039/p29850001905.

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Serna, Manuel, Carlos Wong-Baeza, Juan-Carlos Santiago-Hernández, Isabel Baeza, and Carlos Wong. "Hypocholesterolemic and choleretic effects of three dimethoxycinnamic acids in relation to 2,4,5-trimethoxycinnamic acid in rats fed with a high-cholesterol/cholate diet." Pharmacological Reports 67, no. 3 (2015): 553–59. http://dx.doi.org/10.1016/j.pharep.2014.12.009.

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35

Karimov, O. K., G. Y. Kolchina, G. A. Teptereva, I. A. Chetvertneva, E. K. Karimov, and A. R. Badretdinov. "The reactivity of cinnamic acid derivatives as lignin precursors." Fine Chemical Technologies 15, no. 4 (2020): 7–13. http://dx.doi.org/10.32362/2410-6593-2020-15-4-7-13.

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Objectives. Cinnamic acid derivatives belong to a large class of phenolic compounds, which are widely distributed in plants and have high potential for use in the medical and industrial fields. They have various useful practical properties, e.g., antioxidant, anti-inflammatory, antiplatelet, and anti-melanogenic properties. Hydroxycinnamic acids are of particular interest as phenylpropanoids, which are the starting compounds of lignin. The aim of this work was to study the electronic structure and analyze the reactivity of the simplest representatives of phenylpropanoids formed during the bios

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Abdallah, Heba M. I., Gehad A. Abdel Jaleel, Hala Sh Mohammed, et al. "Phytochemical Screening, Gas Chromatography-mass Spectrometry Analysis, and Antidiabetic Effects of Corchorus olitorius Leaves in Rats." Open Access Macedonian Journal of Medical Sciences 8, A (2020): 385–94. http://dx.doi.org/10.3889/oamjms.2020.3796.

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BACKGROUND: Therapies for diabetes mellitus are still meeting failure in most cases, especially in the developed stages of the disease due to incredible associating complications. Hence, there is a need for continuous development of curative therapies for that stubborn disease. AIM: We aimed to investigate the antidiabetic effects of one of the most popular plants cultivated in Egypt, C. olitorius. METHODS: Phytochemical screening of total alcoholic extract of Corchorus olitorius leaves and its aqueous and chloroform fractions revealed the presence of flavonoids, saponins, carbohyd

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He, Huixin, Liang Qin, Yawen Zhang, et al. "3,4-Dimethoxycinnamic Acid as a Novel Matrix for Enhanced In Situ Detection and Imaging of Low-Molecular-Weight Compounds in Biological Tissues by MALDI-MSI." Analytical Chemistry 91, no. 4 (2019): 2634–43. http://dx.doi.org/10.1021/acs.analchem.8b03522.

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Desiraju, G. R., J. C. Calabrese, and R. L. Harlow. "Pseudoinversion centers in space group P\overline{1} and a redetermination of the crystal structure of 3,4-dimethoxycinnamic acid. A study of non-crystallographic symmetry." Acta Crystallographica Section B Structural Science 47, no. 1 (1991): 77–86. http://dx.doi.org/10.1107/s0108768190008850.

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Elshal, Mahmoud, Abdelrahman Hamdi, Ibrahim T. Khalil та ін. "3,4-Dimethoxycinnamic acid from coffee silverskin biowaste ameliorates bleomycin-induced pulmonary fibrosis via modulating caveolin-1-dependent activation of NF-κB, TGF-β1/Smad3, and ERK1/2 signaling pathways". Toxicology and Applied Pharmacology 501 (серпень 2025): 117414. https://doi.org/10.1016/j.taap.2025.117414.

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Matos,, M. A. R., M. J. S. Monte,, and D. M. Hillesheim. "Standard molar enthalpies of combustion of five trans -dimethoxycinnamic acids." Journal of Chemical Thermodynamics 33, no. 8 (2001): 899–903. http://dx.doi.org/10.1006/jcht.2000.0814.

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Nagy, Kornél, Karine Redeuil, Gary Williamson, et al. "First identification of dimethoxycinnamic acids in human plasma after coffee intake by liquid chromatography–mass spectrometry." Journal of Chromatography A 1218, no. 3 (2011): 491–97. http://dx.doi.org/10.1016/j.chroma.2010.11.076.

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Zou, Yan, Yupeng Chen, Duoduo Wang, et al. "The Effects of Nine Compounds on Aldehyde-Oxidase-Related Genes in Bactrocera dorsalis (Hendel)." Genes 15, no. 1 (2023): 35. http://dx.doi.org/10.3390/genes15010035.

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Bactrocera dorsalis (Hendel) (Diptera: Tephritidae) (B. dorsalis) is an important agricultural, major invasive, and quarantine pest that can cause significant damage to the economic value of the fruit and vegetable industry. Male bait is one of the most effective methods of surveying, monitoring, and controlling B. dorsalis. In our study, we constructed cDNA libraries using total RNA extracted independently from the antennae, mouthparts, and thoracic legs of male and female adults and the ovipositors of female adults and screened out four aldehyde-oxidase-related genes (AOX-related), C58800, C

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Barinova, К., А. Melnikova, and V. Мuronetz. "THE EFFECT OF 3,4-DIMETHOXYCINNAMIC ACID DERIVATIVES ON PATHOLOGICAL AGGREGATION OF ALPHA-SYNUCLEIN." BIOTECHNOLOGY: STATE OF THE ART AND PERSPECTIVES, 2020, 102–4. http://dx.doi.org/10.37747/2312-640x-2020-18-102-104.

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3,4-dimethoxycinnamic acid (3,4-DMCA) derivatives were tested for their ability to inhibit the aggregation of α-synuclein. It was shown that the most effective inhibitors among the selected ones are ferulic, 3-methoxy-4- acetamidoxycinnamic, 3,4-DMCA, the rest of the compounds have imperceptible effect on the aggregation.

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Hải, PhạmThế, Yen Bao Ninh, Que Thi Nguyet Do та ін. "Sàng lọc hợp chất có tác dụng ức chế enzym tyrosinase bằng phương pháp in silico – in vitro". VNU Journal of Science: Medical and Pharmaceutical Sciences 33, № 1 (2017). http://dx.doi.org/10.25073/2588-1132/vnumps.4065.

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Tyrosinase là một đích phân tử quan trọng tham gia vào quá trình hình thành các sắc tố melanin. Ức chế enzym tyrosinase có thể làm hạn chế việc sản sinh quá nhiều các sắc tố melanin từ đó giúp điều trị các rối loạn liên quan đến tăng sắc tố da. Nghiên cứu tìm kiếm hoạt chất có tác dụng ức chế enzym này có ý nghĩa lớn trong khoa học y dược và mỹ phẩm. Trong nghiên cứu này chúng tôi tích hợp phương pháp tính toán lý thuyết (in silico) và thực nghiệm in vitro nhằm tìm kiếm hợp chất có tác dụng ức chế tyrosinase từ cơ sở dữ liệu hóa học Spectrum Collection. Cụ thể, sau khi sàng lọc in silico tìm đ

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Salah, Nesma M., Ahmed M. A. Souleman, Kamel H. Shaker, Seham El Hawary, and Faten K. Abd El-Hady. "Acetylcholinesterase, Alpha-Glucosidase and Tyrosinase Inhibitors from Egyptian Propolis." International Journal of Pharmacognosy and Phytochemical Research 9, no. 4 (2017). http://dx.doi.org/10.25258/phyto.v9i4.8126.

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Bioassay guided fractionation led to the isolation of eight compounds from Egyptian Propolis. Hexacosanoic acid; 3,4- dimethoxy-cinnamic acid; 3-methyl-3-butenyl-trans-caffeate ester; together with four flavonoids (Chrysin; Pinostrobin; Tectochrysin and 5-hydroxy-7-methoxy isoflavone). 2,3-dihydroxy-4-methyl-octanoic acid; was isolated for the first time from Egyptian propolis. Their acetylcholinesterase (AChE), alpha-glucosidase and tyrosinase inhibition potential were evaluated. Pinostorbin showed the highest AChE inhibitory activity followed by 3,4-Dimethoxycinnamic acid; 3-methyl- 3-buteny

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Nguyen, Thi Van Anh, Thi Minh Hang Nguyen, Thi Thoa Ha, Thuy Duong Nguyen, and Duc Huy Bui. "Antiplatelet and Anticoagulant Effects of Two New Phenylpropanoid Sucrose Esters and Other Secondary Metabolites from the Aerial Part of Canna edulis." Chemistry & Biodiversity, March 8, 2024. http://dx.doi.org/10.1002/cbdv.202400302.

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This study isolated pure compounds from Canna edulis aerial parts and assessed their antiplatelet and anticoagulant potential. Structural elucidation resulted in the identification of two new compounds: caneduloside A (1) and caneduloside B (2), and eleven known compounds: 6’‐acetyl‐3,6,2’‐tri‐p‐coumaroyl sucrose (3), 6¢‐acetyl‐3,6,2¢‐triferuloyl sucrose (4), tiliroside (5), afzelin (6), quercitrin (7), 2‐hydroxycinnamaldehyde (8), cinnamic acid (9), 3,4‐dimethoxycinnamic acid (10), dehydrovomifoliol (11), 4‐hydroxy‐3,5‐dimethoxybenzaldehyde (12), and (S)‐(‐)‐rosmarinic acid (13). Compounds 3,

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Dilshad, Sumra, Shabnam, Arif Ali, Shama Firdaus, Musheer Ahmad, and Aiman Ahmad. "Suppression of human lysozyme aggregation by a novel copper-based complex of 3,4-dimethoxycinnamic acid." Journal of Biomolecular Structure and Dynamics, August 14, 2023, 1–13. http://dx.doi.org/10.1080/07391102.2023.2246567.

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Zarrelli, Armando, and Luigi Longobardo. "Improved Chemical Synthesis of Avenanthramides Family and its Analogs by Mixed Anhydride Method." European Journal of Organic Chemistry, April 16, 2025. https://doi.org/10.1002/ejoc.202500169.

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Amides derived from common hydroxycinnamic acids — including 4‐hydroxycinnamic acid, 3‐methoxy‐4‐hydroxycinnamic acid, 3,4‐dihydroxycinnamic acid, 3,4‐dimethoxycinnamic acid, and 3,4,5‐trimethoxycinnamic acid — along with various free aminobenzoic acids, such as 5‐hydroxy‐2‐aminobenzoic acid, a key component of the avenanthramide family, have been rapidly synthesized using an innovative, environmentally friendly synthetic methodology. This approach, grounded in traditional chemistry, utilizes mixed anhydrides to simultaneously protect and activate hydroxycinnamic acids through the actions of t

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Gazali, Mohamad, Fazidatul Lu’luil Maknun, Amir Husni, et al. "Tyrosinase Inhibitory Activity of Methanolic Extract and Fractions from Green Seaweed Ulva lactuca." Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology 20, no. 1 (2025). https://doi.org/10.15578/squalen.915.

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Ulva lactuca, a widely available green seaweed, has demonstrated promisingbioactivity as a tyrosinase inhibitor. This study aimed to evaluate the tyrosinaseinhibitory activity of U. lactuca extracts and identify the active compoundsresponsible. The seaweed was extracted using methanol via maceration,followed by partitioning with hexane, chloroform, and water. Total phenolicand flavonoid contents were determined using UV-VIS spectrophotometry,and tyrosinase inhibition was assessed in vitro. Among the tested fractions,the hexane fraction exhibited the highest tyrosinase inhibitory activity with

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Abe, Kazuma, Miyuki Oshimura, Ryo Kawatani, Tomohiro Hirano, and Koichi Ute. "Synthesis of Photodegradable Polyesters from Bio-Based 3,4-Dimethoxycinnamic Acid and Investigation of Their Degradation Behaviors." Polymer, May 2024, 127204. http://dx.doi.org/10.1016/j.polymer.2024.127204.

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