Academic literature on the topic 'Dimethyl arsenic acid'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Dimethyl arsenic acid.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Journal articles on the topic "Dimethyl arsenic acid"
1
Oh, J. I., T. Urase, H. Kitawaki, M. M. Rahman, M. H. Rhahman, and K. Yamamoto. "Modeling of arsenic rejection considering affinity and steric hindrance effect in nanofiltration membranes." Water Science and Technology 42, no. 3-4 (August 1, 2000): 173–80. http://dx.doi.org/10.2166/wst.2000.0376.
Full textAbstract:
Rejection characteristics of arsenic compounds such as arsenite, dimethyl arsinic acid, and arsenate were examined regarding the effect of pH change in nanofiltration. Rejection mechanism of arsenic compounds was explained by comparing experimental rejection with calculation of the Extended Nernst-Planck model coupled with steric hindrance model. Nanofiltration membranes of the same material show similar rejection characteristics of arsenic compounds in different species. Steric hindrance and electrostatic effect in the nanofiltration membranes was well described by the model because the rejection of chloride, sulfate and arsenate ions, which exist in ionized forms at a wide pH range showed quite good agreement between model calculation and experimental result. The rejection of dimethyl arsenic acid and arsenite required the consideration of mutual interaction between membrane material and solutes as well as steric hindrance and electrostatic effect. A system with ultra low-pressure nanofiltration membrane coupled with pre-oxidation device was suggested for the treatment of arsenic in groundwater in Bangladesh.
2
Bozack, Anne K., Megan N. Hall, Xinhua Liu, Vesna Ilievski, Angela M. Lomax-Luu, Faruque Parvez, Abu B. Siddique, et al. "Folic acid supplementation enhances arsenic methylation: results from a folic acid and creatine supplementation randomized controlled trial in Bangladesh." American Journal of Clinical Nutrition 109, no. 2 (December 24, 2018): 380–91. http://dx.doi.org/10.1093/ajcn/nqy148.
Full textAbstract:
ABSTRACT Background Arsenic exposure through drinking water persists in many regions. Inorganic As (InAs) is methylated to monomethyl-arsenical species (MMAs) and dimethyl-arsenical species (DMAs), facilitating urinary excretion. Arsenic methylation is dependent on one-carbon metabolism, which is influenced by nutritional factors such as folate and creatine. Objective This study investigated the effects of folic acid (FA) and/or creatine supplementation on the proportion of As metabolites in urine. Design In a 24-wk randomized, double-blinded, placebo-controlled trial, 622 participants were assigned to receive FA (400 or 800 μg per day), 3 g creatine per day, 400 μg FA + 3 g creatine per day, or placebo. The majority of participants were folate sufficient; all received As-removal water filters. From wk 12–24, half of the participants receiving FA received placebo. Results Among groups receiving FA, the mean decrease in ln(%InAs) and %MMAs and increase in %DMAs exceeded those of the placebo group at wk 6 and 12 (P < 0.05). In the creatine group, the mean decrease in %MMAs exceeded that of the placebo group at wk 6 and 12 (P < 0.05); creatine supplementation did not affect change in %InAs or %DMAs. The decrease in %MMAs at wk 6 and 12 was larger in the 800 µg FA than in the 400 µg FA group (P = 0.034). There were no differences in treatment effects between the 400 µg FA and creatine + FA groups. Data suggest a rebound in As metabolite proportions after FA cessation; at wk 24, log(%InAs) and %DMAs were not significantly different than baseline levels among participants who discontinued FA supplementation. Conclusions The results of this study confirm that FA supplementation rapidly and significantly increases methylation of InAs to DMAs. Further research is needed to understand the strong cross-sectional associations between urinary creatinine and As methylation in previous studies. This trial was registered at https://clinicaltrials.gov as NCT01050556.
3
Zhao, Fengqin, Chuang Wang, Dongyu Sun, Linlin Zhang, Zhiyue Wang, Jun Piao, Jingai Piao, and Mei Jin. "Effects of sodium arsenite and dimethyl arsenic acid on Liaoning cashmere goat skin fibroblasts." Environmental Science and Pollution Research 28, no. 28 (March 15, 2021): 37918–28. http://dx.doi.org/10.1007/s11356-021-12457-0.
Full text
4
Llorente-Mirandes, Toni, Josep Calderón, José Fermín López-Sánchez, Francesc Centrich, and Roser Rubio. "A fully validated method for the determination of arsenic species in rice and infant cereal products." Pure and Applied Chemistry 84, no. 2 (January 16, 2012): 225–38. http://dx.doi.org/10.1351/pac-con-11-09-30.
Full textAbstract:
A full validation of inorganic arsenic (iAs), methylarsonic acid (MA), and dimethyl arsinic acid (DMA) in several types of rice and rice-based infant cereals is reported. The analytical method was developed and validated in two laboratories. The extraction of the As species was performed using nitric acid 0.2 % and hydrogen peroxide 1 %, and the coupled system liquid chromatography-inductively coupled plasma-mass spectrometry (LCICP-MS) was used for speciation measurements. Detection limit (DL), quantification limit, linearity, precision, trueness, accuracy, selectivity, as well as expanded uncertainty for iAs, MA, and DMA were established. The certified reference materials (CRMs) (NMIJ 7503a, NCS ZC73008, NIST SRM 1568a) were used to check the accuracy. The method was shown to be satisfactory in two proficiency tests (PTs). The broad applicability of the method is shown from the results of analysis of 29 samples including several types of rice, rice products, and infant cereal products. Total As ranged from 40.1 to 323.7 μg As kg–1. From the speciation results, iAs was predominant, and DMA was detected in some samples while MA was not detected in any sample.
5
Akkari, Khalid H., Robert E. Frans, and Terry L. Lavy. "Factors Affecting Degradation of MSMA in Soil." Weed Science 34, no. 5 (September 1986): 781–87. http://dx.doi.org/10.1017/s0043174500067850.
Full textAbstract:
The effects of herbicide concentration, soil water content, and temperature on the fate and degradation of the monosodium salt of methylarsonic acid (MSMA) were evaluated in four soils. Available arsenicals were extracted, purified, and separated using reversed-phase high-performance liquid chromatography (HPLC). Residual MSMA was determined with a graphite furnace atomic absorption spectrophotometer at 193.7 nm. Initial loss of MSMA was rapid, and degradation followed first-order kinetics. The rate of change of the rate constant was temperature dependent only at soil water contents less than field capacity. MSMA dissipation was significantly faster in finer textured soils with continuous flooding and under controlled laboratory conditions (<180 days) than under field (ca. 350 days) conditions. Also, in finer textured soils, degradation of MSMA resulted in significant increases in arsenate and cacodylic acid (dimethyl arsinic acid) over native levels under flooded conditions. However, MSMA treatments contributed only a small fraction to total soil arsenic which dissipated to original concentrations by 120 days. The results indicate that under present recommended use patterns it is highly unlikely that MSMA will accumulate in the environment or carry over from one growing season to the next.
6
Ozpolat, Bulent, Ugur Akar, Magaly Barria, and Gabriel Lopez-Berestein. "PKCδ Regulates Eukaryotic Initiation Factor eIF2α through PKR during Retinoic Acid-Induced Myeloid Cell Differentiation." Blood 108, no. 11 (November 16, 2006): 1928. http://dx.doi.org/10.1182/blood.v108.11.1928.1928.
Full textAbstract:
Abstract Dysregulation of mRNA translation can contribute to malignant transformation. Translation initiation is a rate limiting step of mRNA translation and protein synthesis and plays a critical role in regulation of cell growth, proliferation and differentiation. We previously reported that ATRA induces translational suppression through multiple posttranscriptional mechanisms during terminal cell differentiation detected by proteomic analysis (Harris et al, Blood, 104 (5) 2004). Here we investigated the regulation of translation initiation and the role of eIF2α during terminal differentiation of myeloid leukemia cells. We found that ATRA and other granulocytic differentiation inducing agents, such as dimethyl sulfoxide (DMSO), arsenic trioxide (ATO) induce phosphorylation of eIF2α on serine 51 in promyelocytic leukemia (NB4) cells, indicating the suppression of translation initiation. However, monocytic/macrophagic differentiation of NB4 cells by phorbol 12-myristate 13-acetate (phorbol ester, PMA), or by ATRA in U937 and THP-1 myelomonoblastic myeloid leukemia (AML) cells, was not accompanied with induction of eIF2α phosphorylation. ATRA, ATO or DMSO-induced granulocytic differentiation closely correlated with induction of expression and phosphorylation/activation of protein kinase C-delta (PKCδ) on threonin 505 and serine 643 in NB4 cells. The specific PKCδ inhibitor, rottlerin, markedly inhibited ATRA-induced expression and phosphorylation (serin 51) of eIF2a in NB4 cells. Rottlerin reduced phosphorylation of eIF2α expression not only in the leukemia cells but also in solid tumor cells such as breast (MCF7) and pancreatic (Panc28) cancer cells. Because protein kinase R (PKR) has been shown to inhibit mRNA translation by inducing phosphorylation of eIF2α, we also examined whether this pathway is involved in ATRA-induced phosphorylation of eIF2α and whether it is downstream of PKCδ. We observed that ATRA induces expression and phosphorylation/activation of PKR in NB4 cells. Rottlerin inhibited ATRA-induced expression and activity of PKR , suggesting that activity of PKR is regulated by PKCδ in response to ATRA in NB4 cells. Overall, our data suggest that retinoic acid suppresses translation initiation through PKCδ/PKR/eIF2α pathway during granulocytic but not monocytic differentiation of acute myeloid leukemia cells. These results revealed a novel role of ATRA in granulocytic cell differentiation of myeloid cells. Because malignant cells usually have hyperactivated mRNA translation, targeting translational factors/regulators of initiation may offer new strategies for the treatment of myeloid leukemia cells.
7
Alotaibi, Adullah, Godwin U. Ebiloma, Roderick Williams, Ibrahim A. Alfayez, Manal J. Natto, Sameah Alenezi, Weam Siheri, et al. "Activity of Compounds from Temperate Propolis against Trypanosoma brucei and Leishmania mexicana." Molecules 26, no. 13 (June 26, 2021): 3912. http://dx.doi.org/10.3390/molecules26133912.
Full textAbstract:
Ethanolic extracts of samples of temperate zone propolis, four from the UK and one from Poland, were tested against three Trypanosoma brucei strains and displayed EC50 values < 20 µg/mL. The extracts were fractionated, from which 12 compounds and one two-component mixture were isolated, and characterized by NMR and high-resolution mass spectrometry, as 3-acetoxypinobanksin, tectochrysin, kaempferol, pinocembrin, 4′-methoxykaempferol, galangin, chrysin, apigenin, pinostrobin, cinnamic acid, coumaric acid, cinnamyl ester/coumaric acid benzyl ester (mixture), 4′,7-dimethoxykaempferol, and naringenin 4′,7-dimethyl ether. The isolated compounds were tested against drug-sensitive and drug-resistant strains of T. brucei and Leishmania mexicana, with the highest activities ≤ 15 µM. The most active compounds against T. brucei were naringenin 4′,7 dimethyl ether and 4′methoxy kaempferol with activity of 15–20 µM against the three T. brucei strains. The most active compounds against L. mexicana were 4′,7-dimethoxykaempferol and the coumaric acid ester mixture, with EC50 values of 12.9 ± 3.7 µM and 13.1 ± 1.0 µM. No loss of activity was found with the diamidine- and arsenical-resistant or phenanthridine-resistant T. brucei strains, or the miltefosine-resistant L. mexicana strain; no clear structure activity relationship was observed for the isolated compounds. Temperate propolis yields multiple compounds with anti-kinetoplastid activity.
8
Jay, Z. J., J. P. Beam, A. Dohnalkova, R. Lohmayer, B. Bodle, B. Planer-Friedrich, M. Romine, and W. P. Inskeep. "Pyrobaculum yellowstonensis Strain WP30 Respires on Elemental Sulfur and/or Arsenate in Circumneutral Sulfidic Geothermal Sediments of Yellowstone National Park." Applied and Environmental Microbiology 81, no. 17 (June 19, 2015): 5907–16. http://dx.doi.org/10.1128/aem.01095-15.
Full textAbstract:
ABSTRACTThermoproteales(phylumCrenarchaeota) populations are abundant in high-temperature (>70°C) environments of Yellowstone National Park (YNP) and are important in mediating the biogeochemical cycles of sulfur, arsenic, and carbon. The objectives of this study were to determine the specific physiological attributes of the isolatePyrobaculum yellowstonensisstrain WP30, which was obtained from an elemental sulfur sediment (Joseph's Coat Hot Spring [JCHS], 80°C, pH 6.1, 135 μM As) and relate this organism to geochemical processes occurringin situ. Strain WP30 is a chemoorganoheterotroph and requires elemental sulfur and/or arsenate as an electron acceptor. Growth in the presence of elemental sulfur and arsenate resulted in the formation of thioarsenates and polysulfides. The complete genome of this organism was sequenced (1.99 Mb, 58% G+C content), revealing numerous metabolic pathways for the degradation of carbohydrates, amino acids, and lipids. Multiple dimethyl sulfoxide-molybdopterin (DMSO-MPT) oxidoreductase genes, which are implicated in the reduction of sulfur and arsenic, were identified. Pathways for thede novosynthesis of nearly all required cofactors and metabolites were identified. The comparative genomics ofP. yellowstonensisand the assembled metagenome sequence from JCHS showed that this organism is highly related (∼95% average nucleotide sequence identity) toin situpopulations. The physiological attributes and metabolic capabilities ofP. yellowstonensisprovide an important foundation for developing an understanding of the distribution and function of these populations in YNP.
9
"Breast Cancer Disease and Arsenic: “Geological Behavior (GBR) as Key “." Gynecology and Women’s Health Care, September 14, 2020. http://dx.doi.org/10.47485/2766-5879.1006.
Full textAbstract:
Geology may appear remote from human health. However, rocks are the fundamental building blocks of the Earth’s surface, full of important minerals and chemical elements. Rock weathering and alteration products not only form our soils to support our crops but provide essential elements to build biology. Some heavy metals are carcinogenic, and some only affect the body’s ability to produce red and white cells. In fact, any heavy metal affects any part of the body due to our geological behavior (GBR). For example, a heavy metal may not cause any side effects by contact with the skin, even when swallowed, and may not cause serious harm, but inhaling the vapor of that heavy, toxic metal can cause severe damage to the lungs. Some heavy and quasi metals are more toxic, and some forms of heavy metal compounds are even more dangerous than other forms. Toxic and hazardous heavy metals like arsenic, lead, mercury, zinc, chromium and iron are found in a variety of personal care products, e.g., lipstick, whitening toothpaste, eyeliner and nail color. We use the Anodic Stripping voltammetry (ASV) method for arsenic detection, utilizing the PDV6000 + analyzer (Manufactured B3 Electronics, Perth Australia) configured with a solid gold electrode for total as analyses. Sample Preparation: Spot urine samples were collected from most of the participants from 1 January 2018 to 30 March 2020 after face to face interviews. Women with missing information on adjustment variable(s) were included in the analysis in a separate category for adjustment. Results: Our studies were focus in describing the mean Urinary Arsenic levels (u As) residents of in the central zones of Shiraz, Fasa, Abadeh, Jahrom and Marvdasht to compare the effect of diet such as consuming canned or frozen foods, Consume rice daily, smoking habits and lifestyle on the incidence of Breast. Conclusion: Cancer with arsenic compounds has been reported in many parts of the world. The disease affects all organs of the body, and every year many victims of cancer suffer from severe symptoms and even death. Arsenic compounds are present in the human body and environment in an inorganic and organic form. Inorganic arsenic includes arsenite and arsenic, can also be presented in the environment in the form of methyl (monthly arsenic acid and dimethyl arsenic acid). Arsenic, especially inorganic arsenic, is well absorbed through the gastrointestinal tract rivers (80% -90%) and will be scattered throughout the body. It is often metabolized by methylation and excreted mainly in the urine. Methylation of inorganic arsenic compounds is said to undergo a detoxification process.
10
Ben Hamadi, Naoufel. "Mechanochemical Synthesis and reactivity of 1,2,3-Triazole Carbohydrate Derivatives as Glycogen Phosphorylase Inhibitors." Current Organic Synthesis 17 (December 17, 2020). http://dx.doi.org/10.2174/1570179417666201217142634.
Full textAbstract:
Aims: In this aim, we have developed this work to recommend an original route for the preparation of triazole derivatives. Background: Carbohydrates containing 1,2,3-triazole derivatives have various biological activities. Due to their advantageous and biological property, they are eye-catching synthetic targets in the arsenal of organic chemistry. Thus, finding green and efficient methods, as well as using ball millig procedure for the synthesis of these heterocycles is of interest to organic chemistry researchers. Objective: The objective of this study was to synthesize carbohydrate-derived triazoles under high-speed vibration milling conditions and investigate their properties. Materials and Method: A mixture of glycoside azide derivatives (1 mmol) and prop-2-yn-1-ol (1.5 mmol) in the presence of copper (I) was vigorously shaken under vibration milling conditions at 650 rpm with three balls for 15 min. The deprotection of the resulting triazole derivatives was effected by treatment with 4M hydrochloric acid in methanol under reflux. Results and Discussion: A short and convenient route to synthesize carbohydrate-derived triazoles, based in a ball-mill via 1,3-dipolar cycloaddition reactions to prop-2-yn-1-ol was developed. Cleavage of the isopropylidene protecting group provided water-soluble triazoles, evaluated as glycogen phosphorylase inhibitors. 1-[6-(4-Hydroxymethyl-[1,2,3]triazol-1-yl)- 2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-ethane-1,2-diol was the best inhibitor of rabbit muscle glycogen phosphorylase b (IC50 = 60 μM). Conclusion: In summary, we developed new, short and convenient routes to glucose-derived 1,2,3-triazole based on 1,3- dipolar cycloaddition reactions flowed by ball milling. Use of isopropylidene protective groups gave access to the analogous deprotected water-soluble motifs, analogous to known inhibitors of glycogen phosphorylase.
Dissertations / Theses on the topic "Dimethyl arsenic acid"
1
Navrátilová, Jana. "Metody speciační analýzy sloučenin arsenu." Doctoral thesis, Vysoké učení technické v Brně. Fakulta chemická, 2011. http://www.nusl.cz/ntk/nusl-233337.
Full textAbstract:
Speciační analýza arsenu v různých matricích s využitím HPLC/ICPMS byla předmětem této práce. Toxicita arsenu závisí na oxidačním stavu a formě, ve které je přítomen. Znalost zastoupení specií arsenu je nutná k hodnocení toxicity a biodostupnosti. Obecně, anorganické specie jsou více toxické než organické. V práci byla studována degradace arsenocukrů v mořských řasách za simulovaných přirodních podmínek. Původní arsenocukry byly transformovány na arseničnan a kyselinu dimethylarseničnou. Arsen vstupuje do rostlin z půdy a vody a následně může vstoupit do potravního řetězce. S ohledem na tuto skutečnost byla speciační analýza provedena u vybraných vzorcích rýže, zakoupených v české obchodní síti. Stanovený celkový obsah arsenu se pohyboval v rozmezí 36.06 µg/kg - 218.11 µg/kg a hlavními speciemi byla kyselina dimethylarseničná a anorganický arsen (54-78%). Mořské ryby a tuky obsahují významnou část arsenu ve formě zvané arsenolipidy. Část práce byla zaměřena na analýzu arsenolipidů u máslové ryby (Lepidocybium flavobrunnrum) s celkovým obsahem arsenu 1.8 mg/kg a 22% celkového arsenu bylo vyextrahováno pomocí hexanu, což potvrzuje lipofilni charakter těchto sloučenin. Hlavní specií stanovenou ve vodném extraktu byl arsenobetain, představující 89%.
Book chapters on the topic "Dimethyl arsenic acid"
1
Unger, Thomas A. "Cacodylic Acid (Dimethyl Arsenic Acid)." In Pesticide Synthesis Handbook, 391. Elsevier, 1996. http://dx.doi.org/10.1016/b978-081551401-5.50313-0.
Full text