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Journal articles on the topic 'Diminished Vascularity'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

International, Journal of Medical Science and Innovative Research (IJMSIR). "Radiological Imaging in A Rare Case of Swyer-James-Macleod Syndrome: A Case Report." International Journal of Medical Science and Innovative Research (IJMSIR) 9, no. 4 (2024): 27–29. https://doi.org/10.5281/zenodo.15424213.

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<strong>Abstract</strong> Sweyer James MacLeod syndrome (SJMS), also known as unilateral hyperlucent lung syndrome, is a rare pulmonary disorder characterized by unilateral hypoplasia or agenesis of the pulmonary vasculature, typically affecting one lung. This results in reduced perfusion and subsequent air trapping, leading to unilateral hyperlucency on chest radiographs. Clinical presentation varies widely, often presenting asymptomatically or with recurrent respiratory infections in childhood. Diagnosis requires a combination of clinical history, imaging studies (such as chest radiography,

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Lee, Chia-Hsuan, Hueng-Yuan (Daniel) Shen, Yow-Ling (Shirley) Shiue, Hung-Yen Chan, and Hung-Pin Chan. "Myxofibrosarcoma of the Chest Wall Detected on 99mTc-MDP Whole-Body Bone Scan." Diagnostics 14, no. 8 (2024): 857. http://dx.doi.org/10.3390/diagnostics14080857.

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Myxofibrosarcoma is a type of soft tissue sarcoma, predominantly characterized by a high propensity for local recurrence, albeit demonstrating a relatively diminished risk for distant metastasis. Its prevalence is notably higher in elderly patients. Here, we present a case of a 73-year-old woman diagnosed with Myxofibrosarcoma. She was subjected to a whole-body bone scan using 99mTc-methylene diphosphonate (MDP) to survey potential bony metastasis. It revealed marked MDP accumulation with peripheral soft tissue uptake in the right lateral chest region of this patient. This imaging phenotype co

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Prabhu, Vikram C., Mark H. Bilsky, Kedar Jambhekar, et al. "Results of preoperative embolization for metastatic spinal neoplasms." Journal of Neurosurgery: Spine 98, no. 2 (2003): 156–64. http://dx.doi.org/10.3171/spi.2003.98.2.0156.

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Object. Arterial embolization reduces blood loss in patients undergoing surgery for hypervascular spinal tumors. The objectives of this study were twofold: 1) to evaluate the role of magnetic resonance (MR) imaging in predicting tumor vascularity and 2) to assess the effectiveness of preoperative embolization in devascularizing these tumors. Methods. Fifty-one patients with metastatic spinal neoplasms underwent angiography, preoperative embolization, and excision of the lesion between 1995 and 2000. The MR imaging studies were correlated with tumor vascularity on angiograms. Embolization was a

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Lazaro, Lionel E., Jonathan P. Dyke, Adam Cady, and Michael B. Banffy. "Femoral Head Vascularity After Arthroscopic Femoral Osteochondroplasty: An In Vivo Dynamic Contrast–Enhanced MRI Study." Orthopaedic Journal of Sports Medicine 10, no. 12 (2022): 232596712211393. http://dx.doi.org/10.1177/23259671221139355.

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Background: A serious concern with surgical procedures around the hip joint is iatrogenic injury of the arterial supply to the femoral head (FH) and consequent development of FH osteonecrosis. Cam-type morphology can extend to the posterosuperior area. Understanding the limit of the posterior superior extension of the femoral osteochondroplasty is paramount to avoid underresection and residual impingement while maintaining FH vascularity. Purpose/Hypothesis: The aim of this study was to quantify the impact of arthroscopic femoral osteochondroplasty on the FH vascular supply. It was hypothesize

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Cooper, Laura, Rodney K. Chan, Phillip Kemp Bohan, Anders H. Carlsson, and Tyler Everett. "642 The Use of Laser Speckle Contrast Imaging in Assessing Depth and Progression of Burn Wounds." Journal of Burn Care & Research 41, Supplement_1 (2020): S166—S167. http://dx.doi.org/10.1093/jbcr/iraa024.262.

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Abstract Introduction The ability of laser speckle contrast imaging (LSCI) to provide real-time images of blood flow makes this modality appealing in the assessment of burn wounds, particularly for clinicians making treatment decisions based on burn wound depth and presumed progression. Here we present 2 preclinical studies that used LSCI to assess wound progress, both immediately and months after injury. Methods LSCI images were taken 10-40cm away from the wound and captured with a 1388x1038-pixel CCD camera. In the first study, LSCI images were captured prior to and immediately following cre

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Mignemi, Nicholas, Heather Cole, Masato Yausa, David Gailani, Jay L. Degen, and Jonathan G. Schoenecker. "Deficiency in Plasminogen Cause Decreased Vascularity in Sold Tissue Organs and Bone." Blood 118, no. 21 (2011): 857. http://dx.doi.org/10.1182/blood.v118.21.857.857.

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Abstract Abstract 857 A sufficient vascular supply is critical for proper physiologic function of solid-tissue organs and bone. Tissue vascularity is mediated concomitantly through vascular patency and angiogenesis. Recently, numerous studies have associated plasminogen, the key fibrinolytic protease of the coagulation system, with maintaining vascular patency by preventing fibrin accumulation with in the vasculature. Additionally, plasminogen may also have a direct role in angiogenesis as it has been shown in vitro that inhibitors of plasmin(ogen) suppress formation of capillary structures fr

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Cheung, Anthony T. W., Peter C. Y. Chen, Edward C. Larkin, et al. "Microvascular abnormalities in sickle cell disease: a computer-assisted intravital microscopy study." Blood 99, no. 11 (2002): 3999–4005. http://dx.doi.org/10.1182/blood.v99.11.3999.

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The conjunctival microcirculation of 18 homozygous sickle cell disease (SCD) patients during steady-state, painful crisis, and postcrisis conditions was recorded on high-resolution videotapes using intravital microscopy. Selected videotape sequences were subsequently coded, frame-captured, studied, and blindly analyzed using computer-assisted image analysis protocols. At steady-state (baseline), all SCD patients exhibited some of the following morphometric abnormalities: abnormal vessel diameter, comma signs, blood sludging, boxcar blood flow phenomenon, distended vessels, damaged vessels, hem

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Bartolomé-Sesé, Isabel, María D. Díaz-Barreda, Elvira Orduna-Hospital, Ana Boned-Murillo, Francisco J. Ascaso, and Isabel Pinilla. "Long-Term Follow-Up of Macular Perfusion Evaluated by Optical Coherence Tomography Angiography after Rhegmatogenous Retinal Detachment Surgery." Journal of Clinical Medicine 11, no. 22 (2022): 6725. http://dx.doi.org/10.3390/jcm11226725.

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Background: The goal of this study was to investigate macular microvascular changes using optical coherence tomography angiography (OCTA) at one year after successful rhegmatogenous retinal detachment (RRD) surgery. Methods: We performed a cross-section study including RRD treated by pars plana vitrectomy (PPV) with or without scleral buckling and SF6 tamponade. After 12 months, DRI-Triton SS-OCTA was performed. Superficial and deep retinal capillary plexuses (SCP and DCP), choriocapillaris (CC) vessel density (VD), and foveal avascular zone (FAZ) morphology were analyzed. Results were compare

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Kandasamy, Sindhuja, Divya Agarwal, and Rohan Chawla. "Multimodal imaging of reactive retinal astrocytic vasoproliferative tumour in a case of systemic tuberculosis." BMJ Case Reports 16, no. 1 (2023): e244642. http://dx.doi.org/10.1136/bcr-2021-244642.

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A man in his 20s presented with diminished vision in the left eye. He had a history of Pott’s spine and had been diagnosed elsewhere as having left eye tubercular granuloma in the retina. He was started on anti-tubercular therapy and high-dose oral steroids. He presented to us 1 month later. Presently fundus examination revealed a yellow to whitish mass temporal to disc with diffuse hard exudates throughout the retina. Swept-source optical coherence tomography (SSOCT) revealed a hyper-reflective mass involving the retina. SSOCT angiography and fundus fluorescein angiography revealed vascularit

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Charron, Paul, and Jeff Smith. "Intramuscular Myxomas: A Clinicopathologic Study with Emphasis on Surgical Management." American Surgeon 70, no. 12 (2004): 1073–77. http://dx.doi.org/10.1177/000313480407001208.

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Intramuscular myxomas (IMs) are rare myxoid tumors named for their abundance of noncollagenous mucinous stroma. IMs are benign tumors characterized by a paucity of cells, diminished vascularity, and minimal mitotic figures. The objectives of this study were to examine clinicopathologic features of IM and to discuss clinical management of these unusual soft tissue tumors. A 10-year retrospective study at Orlando Regional Medical Center was conducted from May 1993 to May 2003. A case report of a 48-year-old male with a right gluteal mass is presented. Four cases with histologically confirmed dia

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Shi, Chung-Sheng, Kuan-Lin Kuo, Mei-Sin Chen, et al. "Suppression of Angiogenesis by Targeting Cyclin-Dependent Kinase 7 in Human Umbilical Vein Endothelial Cells and Renal Cell Carcinoma: An In Vitro and In Vivo Study." Cells 8, no. 11 (2019): 1469. http://dx.doi.org/10.3390/cells8111469.

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Cancer cells rely on aberrant transcription for growth and survival. Cyclin-dependent kinases (CDKs) play critical roles in regulating gene transcription by modulating the activity of RNA polymerase II (RNAPII). THZ1, a selective covalent inhibitor of CDK7, has antitumor effects in several human cancers. In this study, we investigated the role and therapeutic potential of CDK7 in regulating the angiogenic activity of endothelial cells and human renal cell carcinoma (RCC). Our results revealed that vascular endothelial growth factor (VEGF), a critical activator of angiogenesis, upregulated the

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Y. Amakpa, Eric, Gertrudis A. Hernandez-Gonzalez, and Edith Camejo-Rodriguez. "Small bowel evisceration in a perforated uterine prolapse." Ghana Medical Journal 55, no. 2 (2021): 156–59. http://dx.doi.org/10.4314/gmj.v55i2.10.

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The evisceration of the bowel through the vaginal vault is an extremely rare condition and a surgical emergency with a high-reported mortality rate. Vaginal evisceration most commonly affects menopausal women with a hysterectomy or those with previous vaginal surgery. The most common risk factors include the triad of post-menopausal atrophy, previous vaginal surgery and enterocele. Estrogen deficiency in post-menopausal women leads to weaker pelvic support structures and a thin, atrophic vagina, making it more prone to rupture. Previous vaginal surgery leaves scar tissue with diminished vascul

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Lazaro, Lionel E., Naomi Gadnisky, Craig Klinger, et al. "QUANTITATIVE ANALYSIS OF THE VASCULARITY OF SKELETALLY IMMATURE FEMORAL CONDYLES: A CADAVER STUDY USING CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING." Orthopaedic Journal of Sports Medicine 7, no. 3_suppl (2019): 2325967119S0014. http://dx.doi.org/10.1177/2325967119s00143.

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Background: The arterial supply to the chondroepiphysis is of paramount importance for proper nutrition and development. Previous animal studies had demonstrated that ischemic necrosis of the chondroepiphysis plays an important role in subsequent development of osteochondritis dissecans (OCD). Previous studies using susceptibility weighted imaging, a magnetic resonance image (MRI) sequence, demonstrated a pattern of disappearance of the arterial system over time at predilection sites for OCD lesions. The purposed of this study is to quantify distribution of the arterial perfusion in different

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Kotsifaki, Amalia, Georgia Kalouda, Sousanna Maroulaki, Athanasios Foukas, and Athanasios Armakolas. "The Genetic and Biological Basis of Pseudoarthrosis in Fractures: Current Understanding and Future Directions." Diseases 13, no. 3 (2025): 75. https://doi.org/10.3390/diseases13030075.

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Pseudoarthrosis—the failure of normal fracture healing—remains a significant orthopedic challenge affecting approximately 10–15% of long bone fractures, and is associated with significant pain, prolonged disability, and repeated surgical interventions. Despite extensive research into the pathophysiological mechanisms of bone healing, diagnostic approaches remain reliant on clinical findings and radiographic evaluations, with little innovation in tools to predict or diagnose non-union. The present review evaluates the current understanding of the genetic and biological basis of pseudoarthrosis

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Radek, Katherine A., Elizabeth J. Kovacs, Richard L. Gallo, and Luisa A. DiPietro. "Acute ethanol exposure disrupts VEGF receptor cell signaling in endothelial cells." American Journal of Physiology-Heart and Circulatory Physiology 295, no. 1 (2008): H174—H184. http://dx.doi.org/10.1152/ajpheart.00699.2007.

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Physiological angiogenesis is regulated by various factors, including signaling through vascular endothelial growth factor (VEGF) receptors. We previously reported that a single dose of ethanol (1.4 g/kg), yielding a blood alcohol concentration of 100 mg/dl, significantly impairs angiogenesis in murine wounds, despite adequate levels of VEGF, suggesting direct effects of ethanol on endothelial cell signaling (40). To examine the mechanism by which ethanol influences angiogenesis in wounds, we employed two different in vitro angiogenesis assays to determine whether acute ethanol exposure (100 m

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Dasani, Megha, Hwa Jeong Lee, and Asha Rijhsinghani. "Deciduoma, a Large Intrauterine Mass of Deciduosis." American Journal of Perinatology Reports 09, no. 04 (2019): e337-e340. http://dx.doi.org/10.1055/s-0039-1697647.

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AbstractDeciduosis is the presence of ectopic decidual tissue outside the uterus, pelvic, or abdominal organs usually associated with pregnancy. It usually presents as smaller lesions but can be larger vascular lesions. Typically, these masses are detected incidentally during operative procedures. Our patient was referred at 14 weeks for a large intrauterine mass detected on ultrasound examination that was initially thought to be an acardiac twin. The mass was highly vascularized. However, since the patient was asymptomatic, she strongly desired to continue the pregnancy. The pregnancy was fol

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Miller, Mia E., Ivan A. Lopez, Fred H. Linthicum, and Akira Ishiyama. "Connexin 26 Immunohistochemistry in Temporal Bones With Cochlear Otosclerosis." Annals of Otology, Rhinology & Laryngology 127, no. 8 (2018): 536–42. http://dx.doi.org/10.1177/0003489418779410.

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Hypothesis: Connexin-26 (Cx26) expression is diminished in the spiral ligament of subjects with hearing loss and cochlear otosclerosis (CO). Background: Human temporal bone (HTB) studies have demonstrated that CO is associated with hyalinization of the spiral ligament. We hypothesize that hyalinization is associated with a loss of fibrocytes with a consequent decline in Cx26 expression. Cx26 and Connexin-30 (Cx30) encode gap junction proteins expressed in supporting cells of the organ of Corti, the spiral limbus, stria vascularis, and in fibrocytes of the spiral ligament. These gap junctions a

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Gibaja, Alejandro, Juan C. Alvarado, Verena Scheper, Liliana Carles, and José M. Juiz. "Kanamycin and Cisplatin Ototoxicity: Differences in Patterns of Oxidative Stress, Antioxidant Enzyme Expression and Hair Cell Loss in the Cochlea." Antioxidants 11, no. 9 (2022): 1759. http://dx.doi.org/10.3390/antiox11091759.

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Kanamycin and cisplatin are ototoxic drugs. The mechanisms are incompletely known. With subcutaneous kanamycin (400 mg/kg, 15 days), auditory threshold shifts were detected at days 12–13 at 16 and 32 kHz, extending to 8 and 4 kHz at days 14–15. The outer hair cell (OHC) loss was concentrated past day 12. The maximum cochlear length showing apoptotic cells, tested with TUNEL, was at day 13. At day 15, 1/5 of the apical cochlea contained preserved OHCs. 3-nitrotyrosine (3-NT) immunolabeling, showing oxidative stress, was found in surviving OHCs and in basal and middle portions of the stria vascu

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Guo, Yangchun, Yiqin Wu, Wenlie Chen, and Jizhen Lin. "Endotoxic damage to the stria vascularis: the pathogenesis of sensorineural hearing loss secondary to otitis media?" Journal of Laryngology & Otology 108, no. 4 (1994): 310–13. http://dx.doi.org/10.1017/s0022215100126623.

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AbstractThis study presents animal experiments on endotoxin (lipopolysaccharides: LPS) damage to the inner ear with special reference to the stria vascularis. The experimental group animals (albino guinea pigs) were injected with LPS into the perilymphatic space. Pyrogen-free saline (PFS) was injected into the control group. Strial structural evaluation and hearing tests were carried out before and one, three and five days after treatment. In PFS-treated (control) ears, no significant change was found either in hearing or structure. However, thresholds of Nl/Pl were elevated and latencies prol

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Jiang, Meiyan, Hongzhe Li, Anastasiya Johnson, et al. "Inflammation up-regulates cochlear expression of TRPV1 to potentiate drug-induced hearing loss." Science Advances 5, no. 7 (2019): eaaw1836. http://dx.doi.org/10.1126/sciadv.aaw1836.

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Aminoglycoside antibiotics are essential for treating life-threatening bacterial infections, despite the risk of lifelong hearing loss. Infections induce inflammation and up-regulate expression of candidate aminoglycoside-permeant cation channels, including transient receptor potential vanilloid-1 (TRPV1). Heterologous expression of TRPV1 facilitated cellular uptake of (fluorescently tagged) gentamicin that was enhanced by agonists, and diminished by antagonists, of TRPV1. Cochlear TRPV1 was immunolocalized near the apical membranes of sensory hair cells, adjacent supporting cells, and margina

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Dib, C., J. Zaatar, O. El Ghawi, et al. "P14.06.B ADVANCES IN INTRAOPERATIVE MAPPING AND VISUALIZATION TECHNIQUES FOR HIGH-GRADE GLIOMA RESECTION: AN UPDATE ON CONTRAST AGENTS AND EMERGING STRATEGIES." Neuro-Oncology 26, Supplement_5 (2024): v78. http://dx.doi.org/10.1093/neuonc/noae144.257.

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Abstract BACKGROUND Brain tumor mapping is crucial for achieving optimal resection, particularly for deep-seated tumors near eloquent areas. Although preoperative contrast-enhanced imaging guides neurosurgeons, its reliability diminishes intraoperatively, necessitating real-time methods for delineating tumor margins. Numerous novel contrast agents and imaging modalities are being investigated for intraoperative visualization of high-grade gliomas (HGG). MATERIAL AND METHODS A narrative review was conducted using the PubMed database to gather review articles and clinical trials published within

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Song, Jianping, Wei Hua, Zhiguang Pan, and Wei Zhu. "Fully Endoscopic Supracerebellar Infratentorial Approach for Resection of Third Ventricle Germ Cell Tumor: 2-Dimensional Operative Video." Operative Neurosurgery 16, no. 3 (2018): 389–90. http://dx.doi.org/10.1093/ons/opy150.

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Abstract Pineal tumor that extends into the posterior portion of the third ventricle is extremely deep-seated and surgically challenging. Various microscopic approaches have been introduced to acquire access to the posterior third ventricle, but still the exposure and visualization are relatively unfavorable. However, recently the application of high-definition endoscope gave neurosurgeons a much more magnified and clearer view of anatomy around the pineal region and third ventricle. The widely used supracerebellar infratentorial approach has been proven to offer a sufficient surgical corridor

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Yustina, Maria, Tomy Lesmana, Alphania Rahniayu, Edwin Danardono, and Denny Septarendra. "Microvessel density as predictor chemotherapy in locally advanced colorectal cancer." Bali Medical Journal 13, no. 1 (2021): 542–47. https://doi.org/10.15562/bmj.v13i1.4985.

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Introduction: Colorectal cancer is the leading cause of morbidity and mortality worldwide. The role of neo-adjuvant chemotherapy in the treatment of locally advanced colorectal cancer (LACRC) has been increased the overall survival. We must consider the benefit and disadvantage of neoadjuvant therapy for LACRC, otherwise window for surgery diminish in progressive disease. The growth of the tumor requires neoangiogenesis, and more aggressive the cancer, more active the angiogenesis. Micro Vessel Density (MVD) is the result of angiogenesis. In our simple thought, the tumor with rich vascular has

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Liu, Arthur, and Michael Curran. "730 Hypoxia reduction in tandem with anti-angiogenic therapy remodels the PDAC microenvironment and potentiates CD40 agonist therapy." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A759. http://dx.doi.org/10.1136/jitc-2021-sitc2021.730.

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BackgroundThe majority of patients with pancreatic ductal adenocarcinoma (PDAC) fail to derive any durable responses from single agent immune checkpoint blockade therapy. This refractory state originates from PDAC's unique tumor microenvironment that is densely populated by immunosuppressive myeloid cells while excluding most antitumor CD8 T cells.1 In addition, PDAC is highly hypoxic and exhibits poor vascularity, both qualities which further limit antitumor immunity.2 3 We showed that the hypoxia-activated prodrug TH-302 (Evofosfamide) potentiates immunotherapy responses.4 Mechanistically, T

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Hofmann, Nicole A., Anna Ortner, Rodrigo O. Jacamo, et al. "Neo-Vasculogenesis In Vivo Is Facilitated by Oxygen Sensing Mesenchymal Stem and Pogenitor Cells." Blood 118, no. 21 (2011): 699. http://dx.doi.org/10.1182/blood.v118.21.699.699.

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Abstract Abstract 699 Rationale: Vascular repair after hypoxic tissue damage requires a stringent interaction between somatic endothelial colony-forming progenitor cells (ECFCs) and mesenchymal stem and progenitor cells (MSPCs). Stem cell therapy to re-vascularize ischemic tissue has been a promising tool for various therapeutic targets including stroke, myocardial infarction and peripheral artery disease. Despite promising experimental data, therapeutic approaches employing endothelial progenitor cells have been of rather limited efficiency in clinical trials for both therapeutic vasculogenes

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Qureshi, Afshan, Sadaf Batool, Asim Shaukat, Tahir Qadeer Khan, Khawaja Khurshid Ahmad, and Muhammad Nawaz Anjum. "Renal transplant complications, role of resistive index on Color Doppler ultrasound." Annals of King Edward Medical University 12, no. 1 (2016). http://dx.doi.org/10.21649/akemu.v12i1.840.

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We evaluated 50 patients who had renal transplants and were sent for Doppler Ultrasound for complications, after the transplant procedure. Ages of the patients ranged from 20 to 65 years, 39 were male and 11 were female. In inclusions only first month post op patients were included and only those patients were considered who had some sort of complications on ultrasound at some stage of the follow up.Following complications were noticed: Diminished corticomedullary demarcations, increased echogenicity with raised R I (20 pt). Perinephric collections other than haematoma (13 pt). Perinephric hae

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Lee, Tony Y., Christopher J. Dy, Wilson Z. Ray, Berdale S. Colorado, and David M. Brogan. "Gray-Scale and Power Doppler Ultrasound Findings Predictive of Cubital Tunnel Syndrome Severity." HAND, October 11, 2022, 155894472211273. http://dx.doi.org/10.1177/15589447221127334.

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Background: The use of ultrasound in the diagnosis of cubital tunnel syndrome (CuTS) is an attractive alternative to electrodiagnostic (EDX) studies, but its utility is binary with poor severity correlation. We hypothesize that increasing ulnar nerve cross-sectional area (CSA) and power Doppler measurement of intraneural vascularity may predict the extent of disease. Methods: We identified 20 elbows from patients with a history of CuTS and 20 elbows in 10 asymptomatic controls. Electrodiagnosis was performed for symptomatic patients. Gray-scale ultrasound and power Doppler ultrasound were perf

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Hoang, Le Q., Bhavya Vaish, Samira Izuagbe, et al. "Histological Analysis of Regenerative Properties in Human Glenoid Labral Regions." American Journal of Sports Medicine, May 26, 2023, 036354652311716. http://dx.doi.org/10.1177/03635465231171680.

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Background: The healing capacity of the human glenoid labrum varies by tear location. Current evidence suggests that the healing capacity of meniscal and cartilage injuries relates to cellular composition and vascularity. However, little is known about the histological characteristics of the glenoid labrum and how they may affect healing potential in specific anatomic regions. Hypothesis: Regenerative characteristics of the glenoid labrum differ based on the anatomic region. Study Design: Descriptive laboratory study. Methods: Human glenoid labra from fresh unpreserved cadavers were transverse

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Sen Sharma, D. "O-217 Nicotinamide mononucleotide-a NAD+ precursor- a new hope for rejuvinating fertility outcome in young infertile women with diminished ovarian reserve- a retrospective analysis." Human Reproduction 40, Supplement_1 (2025). https://doi.org/10.1093/humrep/deaf097.217.

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Abstract Study question Can supplementation of Nicotinamide mononucleotide in young infertile women with diminished ovarian reserve reverse the declining oocyte quality and improve fertility outcome? Summary answer Pretreatment with Nicotinamide mononucleotide increases ovarian response to stimulation and improves oocyte & embryo quality in young low prognosis women with diminished ovarian reserve What is known already Management of women with diminished ovarian reserve( DOR) to stimulation is one of the major challenges in reproductive medicine . The primary cause of DOR in young women re

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Fedje-Johnston, William, Casey P. Johnson, Ferenc Tóth, et al. "A pilot study to assess the healing of meniscal tears in young adult goats." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-021-93405-3.

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AbstractMeniscal tears are a common orthopedic injury, yet their healing is difficult to assess post-operatively. This impedes clinical decisions as the healing status of the meniscus cannot be accurately determined non-invasively. Thus, the objectives of this study were to explore the utility of a goat model and to use quantitative magnetic resonance imaging (MRI) techniques, histology, and biomechanical testing to assess the healing status of surgically induced meniscal tears. Adiabatic T1ρ, T2, and T2* relaxation times were quantified for both operated and control menisci ex vivo. Histology

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Tamboli, Asif Ibrahim, Gonegandlaaejaz Ahmed, and Amol Anantarao Gautam. "Choroidal Metastasis in Myriad of Primary Malignancies: A Cross-sectional Study." INTERNATIONAL JOURNAL OF ANATOMY RADIOLOGY AND SURGERY, 2022. http://dx.doi.org/10.7860/ijars/2022/52659.2744.

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Introduction: All metastatic malignancies commonly metastasise to choroid tissue in eye due to its peculiarity in vascular properties; thereof ocular manifestations are most common in the practice of oncology and ophthalmology. Aim: To investigate the prevalence and clinical pattern of choroidal metastases in myriad of primary malignancies Materials and Methods: This cross-sectional study was conducted from December 2017 to July 2019 , at Krishna Institute of Medical Sciences, Karad, Maharashtra, on 253 patients with confirmed diagnosis of primary malignancies of breast, lung and ovary with on

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Heid, Irina, Marija Trajkovic-Arsic, Fabian Lohöfer, et al. "Functional biomarkers derived from computed tomography and magnetic resonance imaging differentiate PDAC subgroups and reveal gemcitabine-induced hypo-vascularization." European Journal of Nuclear Medicine and Molecular Imaging, September 8, 2022. http://dx.doi.org/10.1007/s00259-022-05930-6.

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Abstract Purpose Pancreatic ductal adenocarcinoma (PDAC) is a molecularly heterogeneous tumor entity with no clinically established imaging biomarkers. We hypothesize that tumor morphology and physiology, including vascularity and perfusion, show variations that can be detected by differences in contrast agent (CA) accumulation measured non-invasively. This work seeks to establish imaging biomarkers for tumor stratification and therapy response monitoring in PDAC, based on this hypothesis. Methods and materials Regional CA accumulation in PDAC was correlated with tumor vascularization, stroma

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Kamiel, Nader, Ashraf N. Moharram, Ayman Shaheen, Mostafa Ezzat, and Walid Ebeid. "Pedicled medial femoral condyle corticoperiosteal flap for achieving union in patients with nonunion of the distal half of the femur (A short case series of three patients)." BMC Musculoskeletal Disorders 26, no. 1 (2025). https://doi.org/10.1186/s12891-025-08644-6.

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Abstract Background Recalcitrant bone nonunion is characterized by impaired biological potential at the fracture site due to diminished vascularity and loss of osteogenic cells, reducing the success rate of nonvascularized bone grafts. In cases of ununited fractures of the tibia and femur with minimal gapping, the medial femoral condyle (MFC) corticoperiosteal flap offers a promising solution. This study aims to evaluate the effectiveness of the pedicled MFC corticoperiosteal flap in achieving union in recalcitrant nonunion of the distal half of the femur. The secondary objective is to report

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Rice, Samuel L., Fernando Gómez Muñoz, Jamaal L. Benjamin, Mhd Wisam Alnablsi, Joseph R. Osborne, and Regina Beets-Tan. "Local and systemic biodistribution of a small-molecule radiopharmaceutical probe after transcatheter embolization and intra-arterial delivery in a porcine orthotopic renal tumor model." Nuclear Medicine Communications, November 19, 2024. http://dx.doi.org/10.1097/mnm.0000000000001928.

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Background Small-molecule biomacromolecules target tumor-specific antigens. They are employed as theranostic agents for imaging and treatment. Intravenous small-molecule radioligands exhibit rapid tumor uptake and excretion. However, systemic administration for peptide receptor radionuclide therapy still lacks the therapeutic index to completely treat solid tumors beyond palliation. We study intra-arterial delivery with tumor embolization of a small molecule as a means to deliver local intertumoral brachytherapy for curative internal ablation. Results 18F-fluorodeoxyglucose (FDG) was used as a

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Xie, Xinya, Qi Cui, Tingting Jiang, et al. "A Critical Role of Endothelial Skp2/PTEN Axis in Angiogenesis and Psoriasis." British Journal of Dermatology, October 18, 2023. http://dx.doi.org/10.1093/bjd/ljad399.

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Abstract Background Psoriasis is a common, chronic skin disorder pathologically featured with abnormal epidermal proliferation, infiltrating inflammatory cells and increased angiogenesis in the dermis. Aberrant expressions of E3 ubiquitin ligase and dysregulated protein ubiquitination system are implicated in the pathogenesis. Objective We aimed to examine the potential role of S-phase kinase-associated protein 2 (Skp2), an E3 ligase and oncogene, in psoriasis. Methods Gene expression and protein levels were evaluated by using qRT-PCR, western blotting, immunohistochemistry and immunofluoresce

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Zhu, Mei-hong, Qian Wen, Tai-nan Lin, et al. "The impact of bilberry extract combined with docosahexaenoic acid on the expression of Chrnb4 gene in the sclera of myopic guinea pigs." Frontiers in Medicine 12 (June 4, 2025). https://doi.org/10.3389/fmed.2025.1590362.

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ObjectiveThis study aimed to investigate the therapeutic potential of bilberry extract combined with docosahexaenoic acid (DHA) in myopia management by examining their effects on Chrnb4 gene expression in the sclera of lens-induced myopic guinea pigs and elucidating the underlying regulatory mechanisms, thereby providing a theoretical foundation for the development of natural active component-based myopia prevention and treatment strategies.MethodsOne hundred twenty guinea pigs were systematically allocated into five experimental groups: normal control (NC), lens-induced myopia (LIM), LIM+DHA,

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Fedele, Carmine, Shuai Li, Kai Wen Teng, et al. "SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling." Journal of Experimental Medicine 218, no. 1 (2020). http://dx.doi.org/10.1084/jem.20201414.

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KRAS is the most frequently mutated human oncogene, and KRAS inhibition has been a longtime goal. Recently, inhibitors were developed that bind KRASG12C-GDP and react with Cys-12 (G12C-Is). Using new affinity reagents to monitor KRASG12C activation and inhibitor engagement, we found that an SHP2 inhibitor (SHP2-I) increases KRAS-GDP occupancy, enhancing G12C-I efficacy. The SHP2-I abrogated RTK feedback signaling and adaptive resistance to G12C-Is in vitro, in xenografts, and in syngeneic KRASG12C-mutant pancreatic ductal adenocarcinoma (PDAC) and non–small cell lung cancer (NSCLC). SHP2-I/G12

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Andino-Lebrón, Katira Nicole, Alejandro Martinó-Morales, and Janet M. "FRI557 Don’t Forget The Incidental Thyroid Nodule In Graves’ Disease. A Case of Marine-Lenhart Syndrome." Journal of the Endocrine Society 7, Supplement_1 (2023). http://dx.doi.org/10.1210/jendso/bvad114.1901.

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Abstract Disclosure: K.N. Andino-Lebrón: None. A. Martinó-Morales: None. J.M. Colón-Castellano: None. Marine-Lenhart syndrome (MLS) was initially described by Charkes in 1972 as he observed patients with Graves’ disease (GD) and incidental functioning thyroid nodules. He named the disease Marine-Lenhart syndrome based on a paper published by Marine and Lenhart in 1911. MLS is a variant of GD now described as the coexistence of GD and autonomous functional thyroid nodules (AFTN); thus, patients present with thyrotoxicosis due to GD and AFTN. MLS is very rare, and prevalence is estimated to be a

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Udagawa, Tomokatsu, Erisa Takahashi, Norifumi Tatsumi, et al. "Loss of Pax3 causes reduction of melanocytes in the developing mouse cochlea." Scientific Reports 14, no. 1 (2024). http://dx.doi.org/10.1038/s41598-024-52629-9.

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AbstractCochlear melanocytes are intermediate cells in the stria vascularis that generate endocochlear potentials required for auditory function. Human PAX3 mutations cause Waardenburg syndrome and abnormalities of skin and retinal melanocytes, manifested as congenital hearing loss (~ 70%) and hypopigmentation of skin, hair and eyes. However, the underlying mechanism of hearing loss remains unclear. Cochlear melanocytes in the stria vascularis originated from Pax3-traced melanoblasts and Plp1-traced Schwann cell precursors, both of which derive from neural crest cells. Here, using a Pax3-Cre k

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Karmacharya, Mrigendra B., Laith R. Sultan, and Chandra M. Sehgal. "Photoacoustic monitoring of oxygenation changes induced by therapeutic ultrasound in murine hepatocellular carcinoma." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-021-83439-y.

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AbstractHepatocellular carcinoma (HCC) is a highly vascular solid tumor. We have previously shown that ultrasound (US) therapy significantly reduces tumor vascularity. This study monitors US-induced changes in tumor oxygenation on murine HCC by photoacoustic imaging (PAI). Oxygen saturation and total hemoglobin were assessed by PAI before and after US treatments performed at different intensities of continuous wave (CW) bursts and pulsed wave (PW) bursts US. PAI revealed significant reduction both in HCC oxygen saturation and in total hemoglobin, proportional to the US intensity. Both CW burst

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Moliner, B., J. Llacer, J. C. Castillo, et al. "P–286 Uterine vascularity in women with previous caesarean section and its potential role in implantation failure: a retrospective cohort study." Human Reproduction 36, Supplement_1 (2021). http://dx.doi.org/10.1093/humrep/deab130.285.

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Abstract Study question Does a previous Caesarean section affect uterine vascularisation the day of embryo transfer? Summary answer 3D vascularisation parameters show less uterine irrigation in patients with previous Caesarean section What is known already A recent retrospective cohort study demonstrates that previous Caesarean section impairs live birth rates after assisted reproductive treatment (ART) compared to a previous vaginal delivery. Furthermore, it has been hypothesized about the mechanisms by which post-cesarean section niche may diminish clinical pregnancy rates. One of the hypoth

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Barkovich, Emil Jernstedt, Suely Fazio Ferraciolli, and Camilo Jaimes. "Abnormal cochlear enhancement in Norrie disease." Neuroradiology Journal, November 24, 2024. http://dx.doi.org/10.1177/19714009241303096.

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Norrie disease (ND) is a rare x-linked disease with retinal and cochlear vascular abnormalities. Clinically, it is characterized by congenital blindness and progressive sensorineural hearing loss during adolescence. We present images of a 3 year old child with ND and normal hearing demonstrating bilateral cochlear enhancement on brain MRI, a finding which has not been previously reported. ND mouse models show progressive degeneration of the endolymph-producing stria vascularis (SV); we hypothesize that these changes allow gadolinium leakage into the endolymph. Our images indicate that cochlear

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Castillo‐Bustamante, Melissa, Prithwijit Roychowdhury, Dhrumi Gandhi, Elliott D. Kozin, and Aaron K. Remenschneider. "Human otopathology in scleroderma." Laryngoscope Investigative Otolaryngology, November 15, 2023. http://dx.doi.org/10.1002/lio2.1180.

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AbstractObjectiveScleroderma is a complex chronic progressive immune‐mediated disease that causes fibrosis of the skin and internal organs, and vasculopathy.Ear involvement has been poorly studied in patients with scleroderma. Vasculitic and autoimmune mechanisms are considered as possible etiologies on hearing impairment, however, this etiology still unclear.Herein, we reviewed three cases of scleroderma from a temporal bone repository.MethodsThe national temporal bone database was reviewed for cases with scleroderma. Clinical case review and correlative otopathologic analysis. Middle and inn

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Chamorro-Jorganes, Aránzazu, Walid K. Sweaad, Rajesh Katare, et al. "METTL3 Regulates Angiogenesis by Modulating let-7e-5p and miRNA-18a-5p Expression in Endothelial Cells." Arteriosclerosis, Thrombosis, and Vascular Biology 41, no. 6 (2021). http://dx.doi.org/10.1161/atvbaha.121.316180.

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Objective: Postnatal angiogenesis is critical in vascular homeostasis and repair. m 6 A (N6-methyladenosine) RNA methylation is emerging as a new layer for fine-tuning gene expression. Although the contribution of the m 6 A-catalyzing enzyme, METTL3 (methyltransferase-like 3), in cancer biology has been described, its role in endothelial cell (EC) function, particularly during angiogenesis, remains unclear. Approach and Results: To characterize the relevance of METTL3 in angiogenesis regulation, we performed gain- and loss-of-function studies in vitro. We demonstrated that depletion of METTL3

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