Academic literature on the topic 'Dipeptidy'

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Journal articles on the topic "Dipeptidy"

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Teshirogi, K., M. Hayakawa, T. Ikemi, and Y. Abiko. "Production of Monoclonal Antibody Inhibiting Dipeptidy-laminopeptidase IV Activity ofPorphyromonas gingivalis." Hybridoma and Hybridomics 22, no. 3 (2003): 147–51. http://dx.doi.org/10.1089/153685903322286557.

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Thiele, D. L., and P. E. Lipsky. "The action of leucyl-leucine methyl ester on cytotoxic lymphocytes requires uptake by a novel dipeptide-specific facilitated transport system and dipeptidyl peptidase I-mediated conversion to membranolytic products." Journal of Experimental Medicine 172, no. 1 (1990): 183–94. http://dx.doi.org/10.1084/jem.172.1.183.

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The mechanism of toxicity for cytolytic lymphocytes of Leu-Leu-OMe and related dipeptide derivatives was examined. Selective inhibition of dipeptidyl peptidase I (DPPI), a lysosomal thiol protease highly enriched in cytotoxic lymphocytes, prevented all natural killer (NK) toxic effects of such agents. However, many DPPI substrates were found to possess no NK toxic properties. For some such agents, this lack of NK toxicity appeared to be related to the lack of uptake by lymphocytes. In this regard, Leu-Leu-OMe was found to be incorporated by lymphocytes and monocytes via a saturable facilitated
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Wenzel, Uwe, Daniela Diehl, Martina Herget, and Hannelore Daniel. "Endogenous expression of the renal high-affinity H+-peptide cotransporter in LLC-PK1 cells." American Journal of Physiology-Cell Physiology 275, no. 6 (1998): C1573—C1579. http://dx.doi.org/10.1152/ajpcell.1998.275.6.c1573.

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The reabsorption of filtered di- and tripeptides as well as certain peptide mimetics from the tubular lumen into renal epithelial cells is mediated by an H+-coupled high-affinity transport process. Here we demonstrate for the first time H+-coupled uptake of dipeptides into the renal proximal tubule cell line LLC-PK1. Transport was assessed 1) by uptake studies using the radiolabeled dipeptided-[3H]Phe-l-Ala, 2) by cellular accumulation of the fluorescent dipeptided-Ala-Lys-AMCA, and 3) by measurement of intracellular pH (pHi) changes as a consequence of H+-coupled dipeptide transport. Uptake o
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Heidenreich, Elena, Tilman Pfeffer, Tamara Kracke, et al. "A Novel UPLC-MS/MS Method Identifies Organ-Specific Dipeptide Profiles." International Journal of Molecular Sciences 22, no. 18 (2021): 9979. http://dx.doi.org/10.3390/ijms22189979.

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Background: Amino acids have a central role in cell metabolism, and intracellular changes contribute to the pathogenesis of various diseases, while the role and specific organ distribution of dipeptides is largely unknown. Method: We established a sensitive, rapid and reliable UPLC-MS/MS method for quantification of 36 dipeptides. Dipeptide patterns were analyzed in brown and white adipose tissues, brain, eye, heart, kidney, liver, lung, muscle, sciatic nerve, pancreas, spleen and thymus, serum and urine of C57BL/6N wildtype mice and related to the corresponding amino acid profiles. Results: A
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Cai, Houjian, Melinda Hauser, Fred Naider, and Jeffrey M. Becker. "Differential Regulation and Substrate Preferences in Two Peptide Transporters of Saccharomyces cerevisiae." Eukaryotic Cell 6, no. 10 (2007): 1805–13. http://dx.doi.org/10.1128/ec.00257-06.

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ABSTRACT Dal5p has been shown previously to act as an allantoate/ureidosuccinate permease and to play a role in the utilization of certain dipeptides as a nitrogen source in Saccharomyces cerevisiae. Here, we provide direct evidence that dipeptides are transported by Dal5p, although the affinity of Dal5p for allantoate and ureidosuccinate is higher than that for dipeptides. Allantoate, ureidosuccinate, and to a lesser extent allantoin competed with dipeptide transport by reducing the toxicity of the peptide Ala-Eth and decreasing the accumulation of [14C]Gly-Leu. In contrast to the well-studie
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Ozawa, Hitoshi, Akiyoshi Hirayama, Futaba Shoji, et al. "Comprehensive Dipeptide Analysis Revealed Cancer-Specific Profile in the Liver of Patients with Hepatocellular Carcinoma and Hepatitis." Metabolites 10, no. 11 (2020): 442. http://dx.doi.org/10.3390/metabo10110442.

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As the physical properties and functionality of dipeptides differ from those of amino acids, they have attracted attention in metabolomics; however, their functions in vivo have not been clarified in detail. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, and its major cause is chronic hepatitis. This study was conducted to explore tumor-specific dipeptide characteristics by performing comprehensive dipeptide analysis in the tumor and surrounding nontumor tissue of patients with HCC. Dipeptides were analyzed by liquid chromatography tandem mass spectrometry and
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Lochs, H., E. L. Morse, and S. A. Adibi. "Uptake and metabolism of dipeptides by human red blood cells." Biochemical Journal 271, no. 1 (1990): 133–37. http://dx.doi.org/10.1042/bj2710133.

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A function of the abundant cytoplasmic peptidases in red blood cells could be hydrolysis of oligopeptides circulating in plasma. To investigate whether human red blood cells actively transport dipeptides for this purpose, these cells were incubated with 14C-labelled glycylproline, glycylsarcosine, glycine, proline and alanine. There was uptake of each dipeptide, as indicated by their recovery as dipeptides in the cell cytoplasm. However, after a brief time (1-2 min) uptake of dipeptides abruptly ceased, while that of amino acids continued. As a result, after 30 min red blood cell uptake of ami
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Anikina, Ye Yu, A. V. Potapov, Ye Yu Varakuta, et al. "Morphological changes of a retina of an eye at influence by laser radiation of threshold intensity with wavelenght 450 nm and their correction by synthetic dipeptid." Bulletin of Siberian Medicine 8, no. 2 (2009): 5–9. http://dx.doi.org/10.20538/1682-0363-2009-2-5-9.

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The analysis of alterations retina of during exposure of threshold laser intensity and opportunities to correct it by synthethic dipeptid. The material and method: 23 rabbits were included in the experiment. Recived matherial was investigated with help of light and electron microscopy. All layers of retina were damaged during laser exposure. The usage of synthethic dipeptide reduced laser damage. Synthethic dipeptid have retinoprotection abilities.
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Li, Chun-Yang, Xiu-Lan Chen, Qi-Long Qin, et al. "Structural Insights into the Multispecific Recognition of Dipeptides of Deep-Sea Gram-Negative Bacterium Pseudoalteromonas sp. Strain SM9913." Journal of Bacteriology 197, no. 6 (2015): 1125–34. http://dx.doi.org/10.1128/jb.02600-14.

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ABSTRACTPeptide uptake is important for nutrition supply for marine bacteria. It is also an important step in marine nitrogen cycling. However, how marine bacteria absorb peptides is still not fully understood. DppA is the periplasmic dipeptide binding protein of dipeptide permease (Dpp; an important peptide transporter in bacteria) and exclusively controls the substrate specificity of Dpp. Here, the substrate binding specificity of deep-seaPseudoalteromonassp. strain SM9913 DppA (PsDppA) was analyzed for 25 different dipeptides with various properties by using isothermal titration calorimetry
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Khalifa, Nagy M., Ahmed M. Naglah, Mohamed A. Al-Omara, and Abd El-Galil E. Amr. "Synthesis and Reactions of New Chiral Linear Dipeptide Candidates Using Nalidixic Acid as Starting Material." Zeitschrift für Naturforschung B 69, no. 6 (2014): 728–36. http://dx.doi.org/10.5560/znb.2014-4031.

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A series of dipeptide heterocyclic derivatives 4-15 were synthesized using methyl 2-{[(1-ethyl- 7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridin-3-yl)carbonyl]amino}-3-ethylbutanoate (3) as starting material. Treatment of 3 with L-phenylalanine methyl ester hydrochloride afforded the corresponding dipeptide methyl ester derivative 4, which was treated with hydrazine hydrate to afford the dipeptide acid hydrazide 5. Compound 5 was coupled with aldehyde and acetophenone derivatives to afford the corresponding Schiff bases 6a-f. The hydrazide derivative 5 was reacted with ethyl acetoacetate or acetone
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Dissertations / Theses on the topic "Dipeptidy"

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Tran, Tinh Vi. "The hydrolysis rate of fluorescent dipeptides by dipeptidyl peptidase I (DPPI)." Thesis, Georgia Institute of Technology, 1999. http://hdl.handle.net/1853/10132.

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Orozco, Erika Vanessa Meñaca. "Síntese e relações estrutura-atividade de dipeptidil-nitrilas inibidoras da cruzaína." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/75/75133/tde-06052015-141806/.

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A cruzaína é a principal cisteíno protease encontrada no parasito Trypanosoma cruzi, o agente etiológico da Doença de Chagas. A enzima é essencial para o desenvolvimento e sobrevivência do parasito dentro do hospedeiro e possui uma excelente validação pré-clínica como alvo susceptível à ação de fármacos. Várias classes de inibidores peptídicos reversíveis e irreversíveis, baseados no estado de transição, inibem efetivamente a cruzaína. No entanto, a maioria destes inibidores ainda não apresenta perfis farmacodinâmicos/farmacocinéticos adequados e/ou estão relacionados com potenciais efeitos fo
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Cardoso, Kiara Carolina 1979. "Transcriptoma da glândula venenífera da serpente Bothrops alternatus (urutu) e caracterização molecular e bioquímica parcial da dipeptidilpeptidase IV." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312156.

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Orientador: Stephen Hyslop<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-19T08:32:10Z (GMT). No. of bitstreams: 1 Cardoso_KiaraCarolina_D.pdf: 27750375 bytes, checksum: a1ca027909bfd58421b986e75bfcd515 (MD5) Previous issue date: 2011<br>Resumo: O estudo do transcriptoma de bibliotecas de cDNA da glândula venenífera de serpentes, realizado a partir da análise de ESTs (expressed sequence tags), tem se mostrado útil na identificação de genes expressos neste tecido, inclusive no gênero Bothrops, responsável pela maio
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Wienand, Wolfgang. "Ein künstlicher Rezeptor für das Dipeptid D-Alanin-D-Alanin Konzeption, Synthese und physikalisch-organische Charakterisierung /." [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=965869032.

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Junior, Daniel Francisco de Arruda. "A inibição da enzima dipeptidil peptidase IV melhora a função cardiorrenal de ratos com insuficiência cardíaca." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5166/tde-09062015-163759/.

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Dados recentes do nosso laboratório sugerem que a enzima dipeptidil peptidase IV (DPPIV), uma serino-protease que pode ser encontrada ancorada na membrana celular de diversos tipos celulares ou na forma solúvel no plasma, possui um papel importante na fisiopatologia da insuficiência cardíaca (IC). Mais especificamente, demonstramos que a atividade da DPPIV circulante está associada com piores desfechos cardiovasculares em modelo experimental e pacientes com IC. Ademais, observamos que a inibição crônica da DPPIV atenua o desenvolvimento e/ou a progressão da IC em ratos submetidos à injúria do
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Gangadharaiah, Dayananda Sagar. "PATTERNS OF DIPEPTIDE USAGE FOR GENE PREDICTION." Wright State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=wright1279304144.

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Knorr, Karsten. "Amidopyrazolylguanidine - neue Haftmonomere für molekular geprägte Polymere." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968544118.

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Kleinsmann, Alexander Jan [Verfasser]. "Untersuchungen zur Selbstassemblierung zyklischer Dipeptide / Alexander Jan Kleinsmann." Tübingen : Universitätsbibliothek Tübingen, 2020. http://d-nb.info/1221596853/34.

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Majumdar, Soumyajit Mitra Ashim K. "Ocular drug delivery evaluation of dipeptide monoester ganciclovir prodrugs /." Diss., UMK access, 2005.

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Thesis (Ph. D.)--School of Pharmacy. University of Missouri--Kansas City, 2005.<br>"A dissertation in pharmaceutical sciences and pharmacology." Advisor: Ashim K. Mitra. Typescript. Vita. Title from "catalog record" of the print edition Description based on contents viewed June 26, 2006. Includes bibliographical references (leaves 174-192). Online version of the print edition.
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Jansson, Lennie. "Purification and refolding of a novel dipeptidyl peptidase III." Thesis, Linköpings universitet, Kemi, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-154013.

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There is a continuous search for novel enzymes to complement the abilities of today’s commercially available enzyme and find tailor-fit alternatives to suit the diverse array of bio-based industries. One application could be to increase biogas yield by finding substrate degrading proteases that can be added to the anaerobic digestion process and survive degradation themselves. A novel enzyme identified as a hypothetical dipeptidyl peptidase III, a zinc dependent metallo-protease, was found by a metaproteogenomics approach to be produced by the microorganisms of a thermophilic biogas process. T
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Books on the topic "Dipeptidy"

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Lendeckel, Uwe, Dirk Reinhold, and Ute Bank, eds. Dipeptidyl Aminopeptidases. Springer US, 2006. http://dx.doi.org/10.1007/0-387-32824-6.

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Preedy, Victor R., ed. Imidazole Dipeptides. Royal Society of Chemistry, 2015. http://dx.doi.org/10.1039/9781782622611.

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Martin, Hildebrandt, ed. Dipeptidyl aminopeptidases in health and disease. Kluwer Academic / Plenum Publishers, 2003.

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Back, Nathan, Irun R. Cohen, David Kritchevsky, Abel Lajtha, and Rodolfo Paoletti, eds. Dipeptidyl Aminopeptidases in Health and Disease. Springer US, 2003. http://dx.doi.org/10.1007/b105297.

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Duffy, Nicola A. Plasma dipeptidyl peptidase IV activity: Role in degradation of enteroinsular hormones and diabetes. The Author], 2004.

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Balanced Nutrition and Therapy (1986 Erlangen, Germany). Dipeptides as new substrates in nutrition therapy =: Peptide als neue Substrate in der Ernährungstherapie. Karger, 1987.

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Fleischer. Dipeptidyl Peptidase IV Metabolism. Springer, 1996.

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Dipeptidyl aminopeptidases in health and disease. Kluwer Academic/Plenum Publishers, 2003.

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Hildebrandt, Martin. Dipeptidyl Aminopeptidases in Health and Disease. Springer, 2013.

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Dipeptidyl aminopeptidases in health and disease. Kluwer Academic/Plenum Publishers, 2003.

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Book chapters on the topic "Dipeptidy"

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Peter, Helga. "Muramyl-Dipeptid." In Springer Reference Medizin. Springer Berlin Heidelberg, 2020. http://dx.doi.org/10.1007/978-3-642-54672-3_643-1.

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Allmendinger, Thomas, Eduard Felder, and Ernst Hungerbuehler. "Fluoroolefin Dipeptide Isosteres." In ACS Symposium Series. American Chemical Society, 1991. http://dx.doi.org/10.1021/bk-1991-0456.ch013.

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Wagner, Leona. "Dipeptidyl Peptidase 4." In Encyclopedia of Signaling Molecules. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_101580.

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Champion, Howard R., Nova L. Panebianco, Jan J. De Waele, et al. "Alanyl-Glutamine Dipeptide." In Encyclopedia of Intensive Care Medicine. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-00418-6_1103.

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Wagner, Leona. "Dipeptidyl Peptidase 4." In Encyclopedia of Signaling Molecules. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-6438-9_101580-1.

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Parant, M., and L. Chedid. "Muramyl Dipeptides." In Handbook of Experimental Pharmacology. Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73217-1_23.

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Barnett, Anthony H., and Jenny Grice. "Dipeptidyl Peptidase-4 Inhibitors." In New Mechanisms in Glucose Control. John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118682197.ch5.

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Schomburg, Dietmar, and Dörte Stephan. "X-Pro dipeptidyl-peptidase." In Enzyme Handbook 15. Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-58948-5_97.

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Deacon, Carolyn F. "Dipeptidyl peptidase-4 inhibitors." In Handbook of Incretin-based Therapies in Type 2 Diabetes. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-08982-9_4.

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De Meester, Ingrid, Anne-Marie Lambeir, Paul Proost, and Simon Scharpé. "Dipeptidyl Peptidase IV Substrates." In Dipeptidyl Aminopeptidases in Health and Disease. Springer US, 2004. http://dx.doi.org/10.1007/0-306-47920-6_1.

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Conference papers on the topic "Dipeptidy"

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León, Iker, José Alonso, Santiago Mata, and Elena Alonso. "A ROTATIONAL STUDY OF ALAALA DIPEPTIDE." In 2020 International Symposium on Molecular Spectroscopy. University of Illinois at Urbana-Champaign, 2020. http://dx.doi.org/10.15278/isms.2020.wj05.

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Liyanage, Wathsala, and Bradley L. Nilsson. "Multicomponent Dipeptide Supramolecular Hydrogels as Fibronectin-Mimetic Biomaterials." In The 24th American Peptide Symposium. Prompt Scientific Publishing, 2015. http://dx.doi.org/10.17952/24aps.2015.134.

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Bermúdez, Celina, José Alonso, Isabel Peña, Carlos Cabezas, and Marcelino Varela. "THE DIPEPTIDE ALA-GLY IN THE GAS PHASE." In 69th International Symposium on Molecular Spectroscopy. University of Illinois at Urbana-Champaign, 2014. http://dx.doi.org/10.15278/isms.2014.td10.

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Behring, Lydia, Christian Trapp, Robert Wodtke, et al. "Dipeptide-derived Alkynes as Novel Irreversible Inhibitors of Cathepsin B." In 35th European Peptide Symposium. Prompt Scientific Publishing, 2018. http://dx.doi.org/10.17952/35eps.2018.064.

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Saxena, Bhawanjali, Kumud Pant, Bhasker Pant, and K. R. Pardasani. "Dipeptide based SVM model for prediction of CDKs and cyclins." In 2nd International Conference on Computer and Automation Engineering (ICCAE 2010). IEEE, 2010. http://dx.doi.org/10.1109/iccae.2010.5451233.

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Rubtsov, Igor V., and Robin M. Hochstrasser. "Vibrational Dynamics, Mode Coupling and Structure of Acetylproline-NH2 Dipeptide." In International Conference on Ultrafast Phenomena. OSA, 2002. http://dx.doi.org/10.1364/up.2002.wd37.

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Kersebohm, Tim, Nils Metzler-Nolte, and Srećko Kirin. "Internal Functionalization of PNA Oligonucleotides via a Substituted Dipeptide Unit." In The 9th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2005. http://dx.doi.org/10.3390/ecsoc-9-01503.

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Sun, Shixin. "Photoionization of dipeptides with femtosecond laser pulses." In RESONANCE IONIZATION SPECTROSCOPY 2000: Laser Ionization and Applications Incorporating RIS; 10th International Symposium. AIP, 2001. http://dx.doi.org/10.1063/1.1405575.

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Gütschow, Michael, Janina Schmitz, Norbert Furtmann, Moritz Ponert, Ulrike Bartz, and Jürgen Bajorath. "Active Site Mapping of Human Cathepsin F with Dipeptide Nitrile Inhibitors." In 1st International Electronic Conference on Medicinal Chemistry. MDPI, 2015. http://dx.doi.org/10.3390/ecmc-1-a038.

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Nakariyakul, Songyot, Zhi-Ping Liu, and Luonan Chen. "Protein interaction prediction for mouse pdz domains using dipeptide composition features." In 2011 IEEE International Conference on Systems Biology (ISB). IEEE, 2011. http://dx.doi.org/10.1109/isb.2011.6033143.

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Reports on the topic "Dipeptidy"

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Unal, C. B., Medge D. Owen-Kummer, and William R. Millington. Beta-Endorphin-Induced Cardiorespiratory Depression is Inhibited by Glycyl-L-Glutamine, a Dipeptide Derived from Beta-Endorphin Processing. Appendix 1. Defense Technical Information Center, 1993. http://dx.doi.org/10.21236/ada283495.

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