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Journal articles on the topic 'Dipeptidy'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Teshirogi, K., M. Hayakawa, T. Ikemi, and Y. Abiko. "Production of Monoclonal Antibody Inhibiting Dipeptidy-laminopeptidase IV Activity ofPorphyromonas gingivalis." Hybridoma and Hybridomics 22, no. 3 (2003): 147–51. http://dx.doi.org/10.1089/153685903322286557.

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2

Thiele, D. L., and P. E. Lipsky. "The action of leucyl-leucine methyl ester on cytotoxic lymphocytes requires uptake by a novel dipeptide-specific facilitated transport system and dipeptidyl peptidase I-mediated conversion to membranolytic products." Journal of Experimental Medicine 172, no. 1 (1990): 183–94. http://dx.doi.org/10.1084/jem.172.1.183.

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The mechanism of toxicity for cytolytic lymphocytes of Leu-Leu-OMe and related dipeptide derivatives was examined. Selective inhibition of dipeptidyl peptidase I (DPPI), a lysosomal thiol protease highly enriched in cytotoxic lymphocytes, prevented all natural killer (NK) toxic effects of such agents. However, many DPPI substrates were found to possess no NK toxic properties. For some such agents, this lack of NK toxicity appeared to be related to the lack of uptake by lymphocytes. In this regard, Leu-Leu-OMe was found to be incorporated by lymphocytes and monocytes via a saturable facilitated

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3

Wenzel, Uwe, Daniela Diehl, Martina Herget, and Hannelore Daniel. "Endogenous expression of the renal high-affinity H+-peptide cotransporter in LLC-PK1 cells." American Journal of Physiology-Cell Physiology 275, no. 6 (1998): C1573—C1579. http://dx.doi.org/10.1152/ajpcell.1998.275.6.c1573.

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The reabsorption of filtered di- and tripeptides as well as certain peptide mimetics from the tubular lumen into renal epithelial cells is mediated by an H+-coupled high-affinity transport process. Here we demonstrate for the first time H+-coupled uptake of dipeptides into the renal proximal tubule cell line LLC-PK1. Transport was assessed 1) by uptake studies using the radiolabeled dipeptided-[3H]Phe-l-Ala, 2) by cellular accumulation of the fluorescent dipeptided-Ala-Lys-AMCA, and 3) by measurement of intracellular pH (pHi) changes as a consequence of H+-coupled dipeptide transport. Uptake o

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4

Heidenreich, Elena, Tilman Pfeffer, Tamara Kracke, et al. "A Novel UPLC-MS/MS Method Identifies Organ-Specific Dipeptide Profiles." International Journal of Molecular Sciences 22, no. 18 (2021): 9979. http://dx.doi.org/10.3390/ijms22189979.

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Background: Amino acids have a central role in cell metabolism, and intracellular changes contribute to the pathogenesis of various diseases, while the role and specific organ distribution of dipeptides is largely unknown. Method: We established a sensitive, rapid and reliable UPLC-MS/MS method for quantification of 36 dipeptides. Dipeptide patterns were analyzed in brown and white adipose tissues, brain, eye, heart, kidney, liver, lung, muscle, sciatic nerve, pancreas, spleen and thymus, serum and urine of C57BL/6N wildtype mice and related to the corresponding amino acid profiles. Results: A

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5

Cai, Houjian, Melinda Hauser, Fred Naider, and Jeffrey M. Becker. "Differential Regulation and Substrate Preferences in Two Peptide Transporters of Saccharomyces cerevisiae." Eukaryotic Cell 6, no. 10 (2007): 1805–13. http://dx.doi.org/10.1128/ec.00257-06.

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ABSTRACT Dal5p has been shown previously to act as an allantoate/ureidosuccinate permease and to play a role in the utilization of certain dipeptides as a nitrogen source in Saccharomyces cerevisiae. Here, we provide direct evidence that dipeptides are transported by Dal5p, although the affinity of Dal5p for allantoate and ureidosuccinate is higher than that for dipeptides. Allantoate, ureidosuccinate, and to a lesser extent allantoin competed with dipeptide transport by reducing the toxicity of the peptide Ala-Eth and decreasing the accumulation of [14C]Gly-Leu. In contrast to the well-studie

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6

Ozawa, Hitoshi, Akiyoshi Hirayama, Futaba Shoji, et al. "Comprehensive Dipeptide Analysis Revealed Cancer-Specific Profile in the Liver of Patients with Hepatocellular Carcinoma and Hepatitis." Metabolites 10, no. 11 (2020): 442. http://dx.doi.org/10.3390/metabo10110442.

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As the physical properties and functionality of dipeptides differ from those of amino acids, they have attracted attention in metabolomics; however, their functions in vivo have not been clarified in detail. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, and its major cause is chronic hepatitis. This study was conducted to explore tumor-specific dipeptide characteristics by performing comprehensive dipeptide analysis in the tumor and surrounding nontumor tissue of patients with HCC. Dipeptides were analyzed by liquid chromatography tandem mass spectrometry and

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7

Lochs, H., E. L. Morse, and S. A. Adibi. "Uptake and metabolism of dipeptides by human red blood cells." Biochemical Journal 271, no. 1 (1990): 133–37. http://dx.doi.org/10.1042/bj2710133.

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A function of the abundant cytoplasmic peptidases in red blood cells could be hydrolysis of oligopeptides circulating in plasma. To investigate whether human red blood cells actively transport dipeptides for this purpose, these cells were incubated with 14C-labelled glycylproline, glycylsarcosine, glycine, proline and alanine. There was uptake of each dipeptide, as indicated by their recovery as dipeptides in the cell cytoplasm. However, after a brief time (1-2 min) uptake of dipeptides abruptly ceased, while that of amino acids continued. As a result, after 30 min red blood cell uptake of ami

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8

Anikina, Ye Yu, A. V. Potapov, Ye Yu Varakuta, et al. "Morphological changes of a retina of an eye at influence by laser radiation of threshold intensity with wavelenght 450 nm and their correction by synthetic dipeptid." Bulletin of Siberian Medicine 8, no. 2 (2009): 5–9. http://dx.doi.org/10.20538/1682-0363-2009-2-5-9.

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The analysis of alterations retina of during exposure of threshold laser intensity and opportunities to correct it by synthethic dipeptid. The material and method: 23 rabbits were included in the experiment. Recived matherial was investigated with help of light and electron microscopy. All layers of retina were damaged during laser exposure. The usage of synthethic dipeptide reduced laser damage. Synthethic dipeptid have retinoprotection abilities.

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9

Li, Chun-Yang, Xiu-Lan Chen, Qi-Long Qin, et al. "Structural Insights into the Multispecific Recognition of Dipeptides of Deep-Sea Gram-Negative Bacterium Pseudoalteromonas sp. Strain SM9913." Journal of Bacteriology 197, no. 6 (2015): 1125–34. http://dx.doi.org/10.1128/jb.02600-14.

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ABSTRACTPeptide uptake is important for nutrition supply for marine bacteria. It is also an important step in marine nitrogen cycling. However, how marine bacteria absorb peptides is still not fully understood. DppA is the periplasmic dipeptide binding protein of dipeptide permease (Dpp; an important peptide transporter in bacteria) and exclusively controls the substrate specificity of Dpp. Here, the substrate binding specificity of deep-seaPseudoalteromonassp. strain SM9913 DppA (PsDppA) was analyzed for 25 different dipeptides with various properties by using isothermal titration calorimetry

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10

Khalifa, Nagy M., Ahmed M. Naglah, Mohamed A. Al-Omara, and Abd El-Galil E. Amr. "Synthesis and Reactions of New Chiral Linear Dipeptide Candidates Using Nalidixic Acid as Starting Material." Zeitschrift für Naturforschung B 69, no. 6 (2014): 728–36. http://dx.doi.org/10.5560/znb.2014-4031.

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A series of dipeptide heterocyclic derivatives 4-15 were synthesized using methyl 2-{[(1-ethyl- 7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridin-3-yl)carbonyl]amino}-3-ethylbutanoate (3) as starting material. Treatment of 3 with L-phenylalanine methyl ester hydrochloride afforded the corresponding dipeptide methyl ester derivative 4, which was treated with hydrazine hydrate to afford the dipeptide acid hydrazide 5. Compound 5 was coupled with aldehyde and acetophenone derivatives to afford the corresponding Schiff bases 6a-f. The hydrazide derivative 5 was reacted with ethyl acetoacetate or acetone

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11

Wang, Furong, Hailiang Shen, Ting Liu, Xi Yang, Yali Yang, and Yurong Guo. "Formation of Pyrazines in Maillard Model Systems: Effects of Structures of Lysine-Containing Dipeptides/Tripeptides." Foods 10, no. 2 (2021): 273. http://dx.doi.org/10.3390/foods10020273.

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At present, most investigations involving the Maillard reaction models have focused on free amino acids (FAAs), whereas the effects of peptides on volatile products are poorly understood. In our study, the formation mechanism of pyrazines, which were detected as characteristic volatiles in sunflower seed oil, from the reaction system of glucose and lysine-containing dipeptides and tripeptides was studied. The effect of the amino acid sequences of the dipeptides and tripeptides on pyrazine formation was further highlighted. Four different dipeptides and six tripeptides were selected. The result

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12

Sargolzaei, Mohsen, and Majid Namayandeh Jorabchi. "Cyclization Effect on pKa of the Side Chain of Aspartic Acid in Dipeptides: A DFT Study." Letters in Organic Chemistry 17, no. 5 (2020): 381–87. http://dx.doi.org/10.2174/1570178616666191019124709.

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Cyclic dipeptides are very important compounds that have a wide range of applications in pharmaceutical chemistry and life sciences. In the current work, the acidity of the side chain of aspartic acid was calculated for various linear and a cyclic dipeptide. pKa values were derived using the thermodynamics cycle and DFT/B3LYP approach. The obtained pKa values show strong acidity for cyclic with respect to linear dipeptides. We found an intramolecular hydrogen bond in cyclic dipeptide structure, which can be used to justify the increasing acidity of the side chain of Asp as compared to linear s

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13

Vikram, Amit, Vanessa M. Ante, X. Renee Bina, Qin Zhu, Xinyu Liu, and James E. Bina. "Cyclo(valine–valine) inhibits Vibrio cholerae virulence gene expression." Microbiology 160, no. 6 (2014): 1054–62. http://dx.doi.org/10.1099/mic.0.077297-0.

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Vibrio cholerae has been shown to produce a cyclic dipeptide, cyclo(phenylalanine–proline) (cFP), that functions to repress virulence factor production. The objective of this study was to determine if heterologous cyclic dipeptides could repress V. cholerae virulence factor production. To that end, three synthetic cyclic dipeptides that differed in their side chains from cFP were assayed for virulence inhibitory activity in V. cholerae. The results revealed that cyclo(valine–valine) (cVV) inhibited virulence factor production by a ToxR-dependent process that resulted in the repression of the v

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14

Ignacio, Melissa, Aaron Smith, and Dmitriy Soldatov. "Co-crystals and inclusion compounds of leucyl-containing dipeptides." Acta Crystallographica Section A Foundations and Advances 70, a1 (2014): C1005. http://dx.doi.org/10.1107/s2053273314089943.

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Short peptides are ecologically friendly and non-toxic molecules, so they can be safely utilized in green chemistry processes or incorporated in pharmaceuticals and food additives. It has been shown that some dipeptides can form crystals that incorporate other molecules through intermolecular hydrogen bonding and van der Waals interactions[1]. The utilization of such dipeptides for solid state organic synthesis or storage and stabilization of bioactive molecules would be of great practical interest, but the principles that define the successful combinations are not clear. In order to identify

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15

Tomić, A., B. Kovačević, and S. Tomić. "Concerted nitrogen inversion and hydrogen bonding to Glu451 are responsible for protein-controlled suppression of the reverse reaction in human DPP III." Physical Chemistry Chemical Physics 18, no. 39 (2016): 27245–56. http://dx.doi.org/10.1039/c6cp04580d.

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16

Ano, Yasuhisa, Tatsuhiro Ayabe, Rena Ohya, Keiji Kondo, Shiho Kitaoka та Tomoyuki Furuyashiki. "Tryptophan-Tyrosine Dipeptide, the Core Sequence of β-Lactolin, Improves Memory by Modulating the Dopamine System". Nutrients 11, № 2 (2019): 348. http://dx.doi.org/10.3390/nu11020348.

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Tryptophan-tyrosine (WY)-related peptides including the β-lactopeptide of the glycine-threonine-tryptophan-tyrosine peptide, β-lactolin, improve spatial memory. However, whether and how the WY dipeptide as the core sequence in WY-related peptides improves memory functions has not been investigated. This study assessed the pharmacological effects of the WY dipeptide on memory impairment to elucidate the mechanisms. Here, we showed that oral administration of dipeptides of WY, tryptophan-methionine (WM), tryptophan-valine, tryptophan-leucine, and tryptophan-phenylalanine improved spontaneous alt

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17

Yamada, Masaki, Chieko Okagaki, Takanori Higashijima, Sumiko Tanaka, Tetsuo Ohnuki, and Takahisa Sugita. "A potent dipeptide inhibitor of dipeptidyl peptidase IV." Bioorganic & Medicinal Chemistry Letters 8, no. 12 (1998): 1537–40. http://dx.doi.org/10.1016/s0960-894x(98)00259-5.

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18

Boduszek, Bogdan, Jozef Oleksyszyn, Chih-Min Kam, Joe Selzler, Robert E. Smith, and James C. Powers. "Dipeptide Phosphonates as Inhibitors of Dipeptidyl Peptidase IV." Journal of Medicinal Chemistry 37, no. 23 (1994): 3969–76. http://dx.doi.org/10.1021/jm00049a016.

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19

Elkins, Amy L., John G. Eley, Merrill C. Miller III, Iris H. Hall, Anup Sood, and Bernard Spielvogel. "Transepithelial Transport and Metabolism of Boronated Dipeptides Across Caco-2 and HCT-8 Cell Monolayers." Metal-Based Drugs 3, no. 6 (1996): 277–86. http://dx.doi.org/10.1155/mbd.1996.277.

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Oral delivery of proteins and peptides as therapeutic agents is problematic due to their low bioavailability. This study examined the effect of boronation on the transepithelial transport and metabolism of three glycine-phenylalanine dipeptides in Caco-2 and HCT-8 cell monolayers. The three dipeptides exhibited passive transport characteristics in the monolayer systems. However, metabolism of the boronated dipeptides did occur, but to a lesser extent than the non-boronated glycine-phenylalanine dipeptide. The same metabolic scheme was seen in both cell monolayer system, but greater metabolism

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20

Abumrad, N. N., E. L. Morse, H. Lochs, P. E. Williams, and S. A. Adibi. "Possible sources of glutamine for parenteral nutrition: impact on glutamine metabolism." American Journal of Physiology-Endocrinology and Metabolism 257, no. 2 (1989): E228—E234. http://dx.doi.org/10.1152/ajpendo.1989.257.2.e228.

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Due to its instability, glutamine is not included in solutions for parenteral solution. This problem can be obviated by providing glutamine as acetyl-, glycyl-, or alanylglutamine. Using an organ balance technique in conscious dogs, we investigated metabolism of these three sources of glutamine. Liver, gut, kidney, and muscle participated in clearance of glycyl- and alanylglutamine from plasma, but among these organs only kidney cleared acetylglutamine. Furthermore, there was a large urinary excretion for acetylglutamine (38 +/- 6% of amount infused) but only a trace amount for either dipeptid

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21

Tsai, Hweiyan, and Stephen G. Weber. "Electrochemical detection of dipeptides and dipeptide amides." Journal of Chromatography A 515 (August 1990): 451–57. http://dx.doi.org/10.1016/s0021-9673(01)89340-7.

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22

Kumar, Santosh, Sujay Kumar Nandi, Saurav Suman, and Debasish Haldar. "A new dipeptide as a selective gelator of Cu(ii), Zn(ii), and Pb(ii)." CrystEngComm 22, no. 45 (2020): 7975–82. http://dx.doi.org/10.1039/d0ce01199a.

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Metallogelation was observed selectively for CuSO<sub>4</sub>, ZnSO<sub>4</sub> and Pb(OAc)<sub>2</sub> and a dipeptide containing N-phenylglycine and l-Phe, whereas other metals and analogue dipeptides failed to form gel.

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23

Odoom, J. E., I. D. Campbell, J. C. Ellory, and G. F. King. "Characterization of peptide fluxes into human erythrocytes. A proton-n.m.r. study." Biochemical Journal 267, no. 1 (1990): 141–47. http://dx.doi.org/10.1042/bj2670141.

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A new protocol for measuring cellular uptake of dipeptides was developed in which the problem of peptide hydrolysis is obviated by introduction into the cell suspension of a membrane-permeant peptidase inhibitor. The uptake of unlabelled dipeptide is readily monitored so long as some analytical technique is available for measuring the intracellular peptide concentration; in this study we used n.m.r. spectroscopy. Using this protocol, we demonstrated that dipeptide uptake by human erythrocytes occurs by simple diffusion through the lipid bilayer and not via a high-capacity protein-mediated tran

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24

van Milgen, Jaap, and Nathalie Le Floc’h. "8 Functional Role of Histidine in Diets of Young Pigs." Journal of Animal Science 99, Supplement_1 (2021): 13. http://dx.doi.org/10.1093/jas/skab054.022.

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Abstract Histidine is a constituent amino acid of body proteins and, once incorporated in protein, histidine can be methylated post-translationally to methyl-histidine. Histidine is also a precursor of histamine, a neurotransmitter and involved in the immune response. Histidine and histamine are constituents of a number of dipeptides, which act as pH buffers, metal chelating agents, and anti-oxidants, especially in skeletal muscles and in the brain. A considerable fraction of whole-body histidine is present as carnosine, the dipeptide of histidine and β-alanine. In the longissimus muscle, abou

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25

Ly, Hong Giang T., Gregory Absillis, and Tatjana N. Parac-Vogt. "Influence of the amino acid side chain on peptide bond hydrolysis catalyzed by a dimeric Zr(iv)-substituted Keggin type polyoxometalate." New Journal of Chemistry 40, no. 2 (2016): 976–84. http://dx.doi.org/10.1039/c5nj00561b.

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Structurally different dipeptides were hydrolyzed by [{α-PW<sub>11</sub>O<sub>39</sub>Zr-(μ-OH)(H<sub>2</sub>O)}<sub>2</sub>]<sup>8−</sup>. The rate constants were dependent on bulkiness and chemical nature of the dipeptide.

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26

Chen, Yu, Kai Tao, Wei Ji, Pandeeswar Makam, Sigal Rencus-Lazar, and Ehud Gazit. "Self-Assembly of Cyclic Dipeptides: Platforms for Functional Materials." Protein & Peptide Letters 27, no. 8 (2020): 688–97. http://dx.doi.org/10.2174/0929866527666200212123542.

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Supramolecular self-assembled functional materials comprised of cyclic dipeptide building blocks have excellent prospects for biotechnology applications due to their exceptional structural rigidity, morphological flexibility, ease of preparation and modification. Although the pharmacological uses of many natural cyclic dipeptides have been studied in detail, relatively little is reported on the engineering of these supramolecular architectures for the fabrication of functional materials. In this review, we discuss the progress in the design, synthesis, and characterization of cyclic dipeptide

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27

Saito, H., and K. Inui. "Dipeptide transporters in apical and basolateral membranes of the human intestinal cell line Caco-2." American Journal of Physiology-Gastrointestinal and Liver Physiology 265, no. 2 (1993): G289—G294. http://dx.doi.org/10.1152/ajpgi.1993.265.2.g289.

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The localization and transport characteristics of dipeptide transporters of the intestinal epithelial cell line Caco-2 were examined by measuring the intracellular accumulation and transcellular flux of Bestatin, a dipeptide-like anticancer agent. When added to the apical surface of Caco-2 monolayers grown on microporous membrane filters, Bestatin was accumulated in the cells and was transported unidirectionally to the basolateral side. The cellular uptake of Bestatin from the basolateral as well as from the apical surface was inhibited by excess dipeptides. Bestatin accumulation from the apic

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28

Liu, Xianxian, and Rebecca E. Parales. "Chemotaxis of Escherichia coli to Pyrimidines: a New Role for the Signal Transducer Tap." Journal of Bacteriology 190, no. 3 (2007): 972–79. http://dx.doi.org/10.1128/jb.01590-07.

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ABSTRACT Escherichia coli exhibits chemotactic responses to sugars, amino acids, and dipeptides, and the responses are mediated by methyl-accepting chemotaxis proteins (MCPs). Using capillary assays, we demonstrated that Escherichia coli RP437 is attracted to the pyrimidines thymine and uracil and the response was constitutively expressed under all tested growth conditions. All MCP mutants lacking the MCP Tap protein showed no response to pyrimidines, suggesting that Tap, which is known to mediate dipeptide chemotaxis, is required for pyrimidine chemotaxis. In order to confirm the role of Tap

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29

Skopicki, H. A., K. Fisher, D. Zikos, et al. "Carrier-mediated transport of pyroglutamyl-histidine in renal brush border membrane vesicles." American Journal of Physiology-Cell Physiology 255, no. 6 (1988): C822—C827. http://dx.doi.org/10.1152/ajpcell.1988.255.6.c822.

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These studies were performed to determine if a transmembrane carrier for pyroglutamyl-histidine (pGlu-His) is present in the luminal membrane of renal proximal tubular cells. Previous studies have suggested the intact transepithelial transport of pGlu-His, a dipeptide formed by the hydrolysis of luteinizing hormone-releasing hormone by enzymes associated with the brush border in the proximal nephron. With the use of a renal brush border membrane vesicle preparation, pGlu-His showed H+-stimulated, Na-independent, saturable transport into an osmotically active space. High-pressure liquid chromat

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30

Trochine, Andrea, Darren J. Creek, Paula Faral-Tello, Michael P. Barrett, and Carlos Robello. "Bestatin Induces Specific Changes in Trypanosoma cruzi Dipeptide Pool." Antimicrobial Agents and Chemotherapy 59, no. 5 (2015): 2921–25. http://dx.doi.org/10.1128/aac.05046-14.

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ABSTRACTProteases and peptidases inTrypanosoma cruziare considered potential targets for antichagasic chemotherapy. We monitored changes in low-mass metabolites inT. cruziepimastigotes treated with bestatin, a dipeptide metalloaminopeptidase inhibitor. After treatment, multiple dipeptides were shown to be increased, confirmingin situinhibition of the leucine aminopeptidase ofT. cruzi(LAPTc) and probably other peptidases.

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31

Lee, Younghee. "Solid-Phase Syntheses of Nω-Propylarginine-Containing Dipeptides, Dipeptide Esters, and Dipeptide Amides". Synthesis 1999, S1 (1999): 1495–99. http://dx.doi.org/10.1055/s-1999-6077.

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32

Kuvaeva, Z. I., and E. G. Karankevich. "Sorption of peptides and amino acids by ion exchangers." Proceedings of the National Academy of Sciences of Belarus, Chemical Series 57, no. 3 (2021): 278–85. http://dx.doi.org/10.29235/1561-8331-2021-57-3-278-285.

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Sorbtion of dipeptides leucylisoleucine, threonylthreonine and their monomeric amino acids leucine and threonine by anionite AV-17 and cationite KU-2-8 in a wide range of equilibrium concentrations has been studied. It was shown that the presence of hydrophilic OH-groups in the threonine molecule promotes superequivalent sorbtion of threonine on the cation exchanger. The presence of an OH-groups in the side chein of the dipeptide practically does not affect the sorbtion an KU-2-8. Sorbtion of dipeptides on AV-17-8 is higher in comparison with their monomeric amino acids.

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Simpkins, Ligaya M., Scott Bolton, Zulan Pi, et al. "Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors." Bioorganic & Medicinal Chemistry Letters 17, no. 23 (2007): 6476–80. http://dx.doi.org/10.1016/j.bmcl.2007.09.090.

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34

Das, Gunajyoti, and Shilpi Mandal. "Nearest-Neighbor Interactions and Their Influence on the Structural Aspects of Dipeptides." Biochemistry Research International 2013 (2013): 1–12. http://dx.doi.org/10.1155/2013/939865.

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In this theoretical study, the role of the side chain moiety of C-terminal residue in influencing the structural and molecular properties of dipeptides is analyzed by considering a series of seven dipeptides. The C-terminal positions of the dipeptides are varied with seven different amino acid residues, namely. Val, Leu, Asp, Ser, Gln, His, and Pyl while their N-terminal positions are kept constant with Sec residues. Full geometry optimization and vibrational frequency calculations are carried out at B3LYP/6-311++G(d,p) level in gas and aqueous phase. The stereo-electronic effects of the side

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35

Otto, C., S. tom Dieck, and K. Bauer. "Dipeptide uptake by adenohypophysial folliculostellate cells." American Journal of Physiology-Cell Physiology 271, no. 1 (1996): C210—C217. http://dx.doi.org/10.1152/ajpcell.1996.271.1.c210.

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Dipeptide uptake was studied in primary cultures from rat anterior pituitaries by use of radiolabeled carnosine and the fluorescent dipeptide derivative beta-Ala-Lys-N epsilon-AMCA (AMCA is 7-amino-4-methylcoumarin-3-acetic acid). Fluorescence microscopic studies revealed that the reporter peptide specifically accumulated in the S-100 positive folliculostellate cells that do not produce any known hormone. The dipeptide derivative was taken up in unmetabolized form by an energy-dependent saturable process with apparent kinetic constants as follows: Michaelis constant, 19 microM; maximum velocit

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36

Van der Veken, Pieter, Ingrid De Meester, Véronique Dubois, et al. "Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 1: Identification of dipeptide derived leads." Bioorganic & Medicinal Chemistry Letters 18, no. 14 (2008): 4154–58. http://dx.doi.org/10.1016/j.bmcl.2008.05.080.

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37

Gudasheva, Tatiana A., Rita U. Ostrovskaya, and Sergey B. Seredenin. "Novel Technologies for Dipeptide Drugs Design and their Implantation." Current Pharmaceutical Design 24, no. 26 (2018): 3020–27. http://dx.doi.org/10.2174/1381612824666181008105641.

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The article is an overview of author’s data obtained in the framework of the project “The Creation of dipeptide preparations” at the V.V. Zakusov Institute of Pharmacology, Moscow, Russia. Advantages of dipeptides over longer peptides consist in that they are orally active owing to higher stability and ability to penetrate biological barriers due to the presence of specific ATP–dependent transporters in enterocytes and blood-brain barrier. Two original approaches for dipeptide drugs design have been developed. Both of them are based on the idea of a leading role of central dipeptide fragment o

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Rahman, Osama Abdel, and Jürgen Grotemeyer. "Formation and Reactions of Clusters in the Gas Phase: Small Peptides and Carboxylic Acids." European Journal of Mass Spectrometry 11, no. 3 (2005): 295–307. http://dx.doi.org/10.1255/ejms.752.

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The cluster formation of 17 small dipeptides with different primary structures and vanillic acid was investigated by means of a neutral laser desorption and supersonic beam expansion followed by multi-photon ionization time of flight mass spectrometry. The structures of these clusters have been characterized by mass spectrometric methods as well as by density functional theory calculations. It shows that the structure of the cluster from a dipeptide and vanillic acid is described by a hydrogen bond between the phenolic group of the vanillic acid and the N-terminal amino function of the dipepti

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Pentzien, Anne-Kathrin, and Hans Meisel. "Transepithelial Transport and Stability in Blood Serum of Angiotensin-I-Converting Enzyme Inhibitory Dipeptides." Zeitschrift für Naturforschung C 63, no. 5-6 (2008): 451–59. http://dx.doi.org/10.1515/znc-2008-5-623.

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The dipeptides Ala-Trp, Val-Phe, and Val-Tyr inhibit the angiotensin-I-converting enzyme. They are encrypted within the primary sequences of different food proteins, e. g. milk proteins. The angiotensin-I-converting enzyme inhibitory potency of these synthetic dipeptides was quantified using a spectrophotometric assay. The dipeptides showed no adverse effects on differentiated Caco-2 cells (model for human intestinal epithelium), as confirmed by transepithelial electrical resistance, microscopy and the activity of the brush-border enzyme dipeptidyl aminopeptidase IV. Furthermore, the transport

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Scaffidi, Adrian, Brian W. Skelton, Robert V. Stick та Allan H. White. "The Synthesis of Some Oligopeptides Derived from Novel Carbohydrate α-Amino Acids". Australian Journal of Chemistry 57, № 8 (2004): 733. http://dx.doi.org/10.1071/ch04014.

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The attempted coupling of a carbohydrate α-azido acid with a carbohydrate α-amino ester in the presence of a diimide, hopefully to produce a dipeptide, yielded only the carboxylic anhydride. However, the combination of 4-toluenesulfonyl chloride in pyridine was successful, and four carbohydrate dipeptides were separately produced. One of these dipeptides was further transformed into a tripeptide, and another into a hexapeptide. A single-crystal X-ray structure is reported for (3S)-3-azido-3-C-carboxy-3-deoxy-1,2:5,6-di-O-isopropylidene-α-d-ribo-hexose, amide with (3S)-3-amino-3-deoxy-1,2:5,6-d

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Gilibili, Ravindranath R., Ravi Kanth Bhamidipati, Ramesh Mullangi, and Nuggehally R. Srinivas. "Retrospective and Prospective Human Intravenous and Oral Pharmacokinetic Projection of Dipeptidyl peptidase-IV Inhibitors Using Simple Allometric Principles – Case Studies of ABT-279, ABT-341, Alogliptin, Carmegliptin, Sitagliptin and Vildagliptin." Journal of Pharmacy & Pharmaceutical Sciences 18, no. 3 (2015): 434. http://dx.doi.org/10.18433/j3tk55.

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Purpose: The purpose of this exercise was to explore the utility of allometric scaling approach for the prediction of intravenous and oral pharmacokinetics of six dipeptidy peptidase-IV (DPP-IV) inhibitors viz. ABT-279, ABT-341, alogliptin, carmegliptin, sitagliptin and vildagliptin. Methods: The availability of intravenous and oral pharmacokinetic data in animals enabled the allometry scaling of 6 DPP-IV inhibitors. The relationship between the main pharmacokinetic parameters [viz. volume of distribution (Vd) and clearance (CL)] and body weight was studied across three or four mammalian speci

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Thong, Bob, James Pilling, Edward Ainscow, Raj Beri, and John Unitt. "Development and Validation of a Simple Cell-Based Fluorescence Assay for Dipeptidyl Peptidase 1 (DPP1) Activity." Journal of Biomolecular Screening 16, no. 1 (2010): 36–43. http://dx.doi.org/10.1177/1087057110385228.

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Dipeptidyl peptidase 1 (DPP1) (EC 3.4.14.1; also known as cathepsin C, cathepsin J, dipeptidyl aminopeptidase, and dipeptidyl aminotransferase) is a lysosomal cysteinyl protease of the papain family involved in the intracellular degradation of proteins. Isolated enzyme assays for DPP1 activity using a variety of synthetic substrates such as dipeptide or peptide linked to amino-methyl-coumarin (AMC) or other fluorophores are well established. There is, however, no report of a simple whole-cell-based assay for measuring lysosomal DPP1 activity other than the use of flow cytometry (fluorescence-a

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Görbitz, Carl Henrik. "Structures of dipeptides: the head-to-tail story." Acta Crystallographica Section B Structural Science 66, no. 1 (2010): 84–93. http://dx.doi.org/10.1107/s0108768109053257.

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The hydrogen-bonding patterns in crystal structures of unprotected, zwitterionic dipeptides are dominated by head-to-tail chains involving the N-terminal amino groups and the C-terminal carboxylate groups. Patterns that include two concomitant chains, thus generating a hydrogen-bonded layer, are of special interest. A comprehensive survey shows that dipeptide structures can conveniently be divided into only four distinct patterns, differing by definition in the symmetry of the head-to-tail chains and amide hydrogen-bonding type, but also in other properties such as peptide conformation and the

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Lan, Vu Thi Tuyet, Keisuke Ito, Masumi Ohno, Takayasu Motoyama, Sohei Ito, and Yasuaki Kawarasaki. "Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor." Food Chemistry 175 (May 2015): 66–73. http://dx.doi.org/10.1016/j.foodchem.2014.11.131.

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Korver, Gretchen E., Chih-Min Kam, James C. Powers, and Dorothy Hudig. "Dipeptide vinyl sulfones suitable for intracellular inhibition of dipeptidyl peptidase I." International Immunopharmacology 1, no. 1 (2001): 21–32. http://dx.doi.org/10.1016/s0162-3109(00)00267-8.

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Van der Veken, Pieter, Anna Soroka, Inger Brandt, et al. "Irreversible Inhibition of Dipeptidyl Peptidase 8 by Dipeptide-Derived Diaryl Phosphonates." Journal of Medicinal Chemistry 50, no. 23 (2007): 5568–70. http://dx.doi.org/10.1021/jm701005a.

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Welch, John T., and Jian Lin. "Fluoroolefin containing dipeptide isosteres as inhibitors of dipeptidyl peptidase IV(CD26)." Tetrahedron 52, no. 1 (1996): 291–304. http://dx.doi.org/10.1016/0040-4020(95)00912-r.

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Skopicki, H. A., K. Fisher, D. Zikos, G. Flouret, and D. R. Peterson. "Low-affinity transport of pyroglutamyl-histidine in renal brush-border membrane vesicles." American Journal of Physiology-Cell Physiology 257, no. 5 (1989): C971—C975. http://dx.doi.org/10.1152/ajpcell.1989.257.5.c971.

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These studies were performed to determine if a low-affinity carrier is present in the luminal membrane of proximal tubular cells for the transport of the dipeptide, pyroglutamyl-histidine (pGlu-His). We have previously described the existence of a specific, high-affinity, low-capacity [transport constant (Kt) = 9.3 X 10(-8) M, Vmax = 6.1 X 10(-12) mol.mg-1.min-1] carrier for pGlu-His in renal brush-border membrane vesicles. In the present study, we sought to demonstrate that multiple carriers exist for the transport of a single dipeptide by determining whether a low-affinity carrier also exist

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Doumas, Agnès, Peter van den Broek, Michael Affolter, and Michel Monod. "Characterization of the Prolyl Dipeptidyl Peptidase Gene (dppIV) from the Koji Mold Aspergillus oryzae." Applied and Environmental Microbiology 64, no. 12 (1998): 4809–15. http://dx.doi.org/10.1128/aem.64.12.4809-4815.1998.

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ABSTRACT The koji mold Aspergillus oryzae secretes a prolyl dipeptidyl peptidase (DPPIV) when the fungus is cultivated in a medium containing wheat gluten as the sole nitrogen and carbon source (MMWG). We cloned and sequenced the DPPIV gene from an A. oryzae library by using the A. fumigatus dppIVgene as a probe. Reverse transcriptase PCR experiments showed that theA. oryzae dppIV gene consists of two exons, the first of which is only 6 bp long. The gene encodes an 87.2-kDa polypeptide chain which is secreted into the medium as a 95-kDa glycoprotein. Introduction of this gene into A. oryzae le

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Joubert, Pascale, Carine Pautigny, Marie-Françoise Madelaine, and Denis Rasschaert. "Identification of a new cleavage site of the 3C-like protease of rabbit haemorrhagic disease virus." Microbiology 81, no. 2 (2000): 481–88. http://dx.doi.org/10.1099/0022-1317-81-2-481.

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The calicivirus rabbit haemorrhagic disease virus (RHDV) possesses a 3C-like protease which processes the RHDV polyprotein. In order to monitor the proteolytic activity of the RHDV 3C-like protease on its putative target sequences, i.e. the 10 EG dipeptide bonds distributed along the large polyprotein, a new approach was carried out. Preliminary experiments showed that the luciferase gene when fused in-frame with a long gene yielded a fusion protein almost devoid of luciferase activity. This reporter system was used to test which EG dipeptide bonds were cleaved by the RHDV protease when the co

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