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Journal articles on the topic 'Diphenyl pyrazoles'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Rai, K. M. Lokanatha, K. B. Umesha, and M. A. Harish Nayaka. "Antioxidant and Antimicrobial Activity of 5-methyl-2-(5-methyl-1,3-diphenyl-1H-pyrazole-4-carbonyl)-2,4-dihydro-pyrazol-3-one." International Journal of Biomedical Science 5, no. 4 (2009): 359–68. http://dx.doi.org/10.59566/ijbs.2009.5359.

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Cycloaddition of nitrile imines 4 generated in situ by the catalytic dehydrogenation of diphenyl hydrazones 3 using Chloramine-T (CAT) as oxidant in glacial acetic acid with enolic form of ethyl acetoacetate 5 afforded Ethyl 3-aryl-5-methyl-1-phenyl-1H-pyrazol-4-carboxylate 6 in 80% yield. The said pyrazoles 6 refluxed with 80% hydrazine hydrate using absolute alcohol as solvent for about 2-3 hours to produce the respective 5-methyl-1,3-diphenyl-1H-pyrazole-4-carboxylic acid hydrazide 7. The alcoholic solution of pyrazole acid hydrazides on heating with ethyl acetoacetate 5 to give the 5-methy

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2

Razmienė, Beatričė, Eva Řezníčková, Vaida Dambrauskienė, et al. "Synthesis and Antiproliferative Activity of 2,4,6,7-Tetrasubstituted-2H-pyrazolo[4,3-c]pyridines." Molecules 26, no. 21 (2021): 6747. http://dx.doi.org/10.3390/molecules26216747.

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A library of 2,4,6,7-tetrasubstituted-2H-pyrazolo[4,3-c]pyridines was prepared from easily accessible 1-phenyl-3-(2-phenylethynyl)-1H-pyrazole-4-carbaldehyde via an iodine-mediated electrophilic cyclization of intermediate 4-(azidomethyl)-1-phenyl-3-(phenylethynyl)-1H-pyrazoles to 7-iodo-2,6-diphenyl-2H-pyrazolo[4,3-c]pyridines followed by Suzuki cross-couplings with various boronic acids and alkylation reactions. The compounds were evaluated for their antiproliferative activity against K562, MV4-11, and MCF-7 cancer cell lines. The most potent compounds displayed low micromolar GI50 values. 4

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3

Abularrage, Nile S., Brian J. Levandowski, and Ronald T. Raines. "Synthesis and Diels–Alder Reactivity of 4-Fluoro-4-Methyl-4H-Pyrazoles." International Journal of Molecular Sciences 21, no. 11 (2020): 3964. http://dx.doi.org/10.3390/ijms21113964.

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4H-Pyrazoles are emerging scaffolds for “click” chemistry. Late-stage fluorination with Selectfluor® is found to provide a reliable route to 4-fluoro-4-methyl-4H-pyrazoles. 4-Fluoro-4-methyl-3,5-diphenyl-4H-pyrazole (MFP) manifested 7-fold lower Diels–Alder reactivity than did 4,4-difluoro-3,5-diphenyl-4H-pyrazole (DFP), but higher stability in the presence of biological nucleophiles. Calculations indicate that a large decrease in the hyperconjugative antiaromaticity in MFP relative to DFP does not lead to a large loss in Diels–Alder reactivity because the ground-state structure of MFP avoids

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4

Nikpour, Farzad, Sara Zandi, and Mahnaz Sharafi-Kolkeshvandi. "Electrochemically Catalyzed N–N Coupling and Ring Cleavage Reaction of 1H-Pyrazoles." Synthesis 53, no. 19 (2021): 3591–96. http://dx.doi.org/10.1055/s-0040-1706050.

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AbstractThe electrocatalyzed N–N coupling and ring cleavage reaction of 3-methyl-, 3,5-dimethyl-, 3-methyl-5-phenyl- and 3,5-diphenyl-1H-pyrazole was investigated and led to the electro-organic synthesis of new heterocyclic compounds. The results revealed that electrochemically produced 1H-pyrazoleox plays the role of acceptor in a reaction with the starting molecule via a N–N coupling and ring cleavage reaction of pyrazoles. The proposed reaction sequence consists of anodic oxidation, dimerization, rearrangement and reduction. The electrochemically catalyzed reactions were accomplished under

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5

Hartwig de Oliveira, Daniela, Fernanda Severo Sabedra Sousa, Paloma Taborda Birmann, et al. "Evaluation of antioxidant activity and toxicity of sulfur- or selenium-containing 4-(arylchalcogenyl)-1H-pyrazoles." Canadian Journal of Physiology and Pharmacology 98, no. 7 (2020): 441–48. http://dx.doi.org/10.1139/cjpp-2019-0356.

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Pyrazoles represent a significant class of heterocyclic compounds that exhibit pharmacological properties. The present study aimed to investigate the antioxidant potential of pyrazol derivative compounds in brain of mice in vitro and the effect of pyrazol derivative compounds in the oxidative damage and toxicity parameters in mouse brain and plasma of mice. The compounds tested were 3,5-dimethyl-1-phenyl-4-(phenylselanyl)-1H-pyrazol (1a), 3,5-dimethyl-4-(phenylselanyl)-1H-pyrazole (2a), 4-((4-methoxyphenyl)selanyl)-3,5-dimethyl-1-phenyl-1H-pyrazole (3a), 4-((4-chlorophenyl)selanyl)-3,5-dimethy

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6

Mohd., Amir, Alam Khan Shah, and Drabu S. "Synthesis and antibacterial activity of 4-arylazo-1-substituted- 3,5-diphenylpyrazoles." Journal of Indian Chemical Society Vol.79, Mar 2002 (2002): 280–81. https://doi.org/10.5281/zenodo.5849647.

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Department of Pharmaceutical Chemistry, Hamdard University, Hamdard Nagar, New Delhi-11 0 062 <em>E-mail</em> : amirs@vsnl.net <em>Manuscript received 27 April 200/, revised 30 July 2001, accepted 17 August 2001</em> Various 4-arylazo-1-(2-acetonaphthyl)-3,5-diphenyl pyrazoles (2a-g), 4-arylazo-1-isonicotinyl-3,5-diphenyl pyrazoles (3a-g) and 4-arylazo-1-thiocarbamoyl-3,5-diphenylpyrazoles (4a-g) have been synthesized and evaluated for their antibacterial activity. The compounds show significant antibacterial activity.

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7

Cetin, Adnan. "Synthesis of Novel Bis-pyrazoles via Electrophilic Cyclization." Letters in Organic Chemistry 16, no. 6 (2019): 511–16. http://dx.doi.org/10.2174/1570178615666181106155555.

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Efficient steps towards the synthesis of novel (phenyl)(1&#039;-aryl-1,5,5&#039;-triphenyl[3,3&#039;-bi-1Hpyrazol]- 4-yl)methanones 4a-e were developed. The procedure starts from 1-(4-benzoyl-1,5-diphenyl- 1H-3-pyrazolyl)-3-phenyl-2-propyn-1-one (2) which was synthesized by a palladium catalyzed crosscoupling reaction. Compound 2 reacted with various hydrazines to give (E)-(phenyl)[1,5-diphenyl-3- [3-phenyl-1-(2-arylhydrazono)-2-propyn-1-yl]-1H-4-pyrazolyl]methanones E-3a-e. The bis-pyrazole derivatives 4a-e were synthesized from electrophilic cyclization reaction of &#945;,&am

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8

Rajeev, Jain, Padmaja P., Bhadauria Jyoti, and Tomar Sandeep. "Synthesis of some potential antibacterial pyrazoles and pyrazolones." Journal of Indian Chemical Society Vol. 77, Jan 2000 (2000): 42–43. https://doi.org/10.5281/zenodo.5861734.

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School of Studies in Chemistry, Jiwaji University, Gwalior-474 011, India <em>Manuscript received 6 May 1996, revised 22 July 1999, accepted 30 July 1999</em> 1-Guanyl-3-methyl-4-[4'-(substituted)sulphonamoyl]hydrazono-2-pyrazolin-5-one nitrate and 1-guanyl-3,5-diphenyl-4-[4'-(substituted)- sulphonamoyl]azopyrazole nitrate have been synthesised and characterised by spectral techniques.

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9

Bhat, B. A., S. C. Puri, M. A. Qurishi, K. L. Dhar, and G. N. Qazi. "Synthesis of 3,5‐Diphenyl‐1H‐Pyrazoles." Synthetic Communications 35, no. 8 (2005): 1135–42. http://dx.doi.org/10.1081/scc-200054225.

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10

Chovatia, P. T., J. D. Akabari, P. K. Kachhadia, P. D. Zalavadia, and H. S. Joshi. "Synthesis and selective antitubercular and antimicrobial inhibitory activity of 1-acetyl-3,5-diphenyl-4,5-dihydro-(1h)-pyrazole derivatives." Journal of the Serbian Chemical Society 71, no. 7 (2006): 713–20. http://dx.doi.org/10.2298/jsc0607713c.

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The new compounds 1-aryl-3-{1-phenyl-3-[p (methylthio)phenyl]pyrazol-4-yl}-2-propen-1-ones 2a?l were prepared by the condensation of 1-phenyl-3-[p (methylthio)phenyl]-4-formylpyrazole 1 with different aryl ketones. Compounds 2a?l in reaction with hydrazine hydrate yielded 3-aryl-5-{1-phenyl-3-[p-(methylthio)phenyl]pyrazol-4 yl}-4,5-dihydro-(1H)-pyrazoles 3a?l and in the presence of hydrazine hydrate in glacial acetic acid gave 1-acetyl-3-aryl 5-{1-phenyl-3-[p-(methylthio)phenyl]pyrazol-4-yl}-4,5 dihydro-(1H)-pyrazoles 4a?l. These compounds were tested in vitro for their antitubercular and anti

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11

Venkata Narsimha Reddy, Chintalapani, Eligeti Rajanarendar, and Ananthula Krishnamurthy. "Synthesis of 3-methyl-1,5-diphenyl-7-aryl-7,8-dihydro-6H-pyrazolo[4,5-b]azepines." Collection of Czechoslovak Chemical Communications 55, no. 4 (1990): 1055–58. http://dx.doi.org/10.1135/cccc19901055.

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3,5-Dimethyl-4-nitro-1-phenylpyrazole (I) on treatment with chalcones II under phase transfer conditions gives the Michael adducts, 3-methyl-4-nitro-1-phenyl-5-(2-aryl-4-phenyl-4-oxo-1-butyl)pyrazoles (III). The Michale adducts on cycloreduction with stannous chloride-hydrochloric acid furnish 3-methyl-1,5-diphenyl-7-aryl-7,8-dihydro-6H-pyrazolo[4,5-b]azepines (IV). IR, 1H NMR, 13C NMR and mass spectra support the structures of III and IV.

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12

Sa, Shreenibasa, Vanga Mukundam, Anupa Kumari, Ritwick Das, and Krishnan Venkatasubbaiah. "Synthesis of pyrazole anchored three-coordinated organoboranes and their application in the detection of picric acid." Dalton Transactions 50, no. 18 (2021): 6204–12. http://dx.doi.org/10.1039/d1dt00586c.

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13

Gaddam, Ganga Reddy, Pramod Kumar Dubey, and Venkata Ramana Reddy Chittireddy. "Synthesis of Indolyl Pyrazole Scaffolds as Potential Anti-cancer Agents and their Molecular Modelling Studies." Letters in Drug Design & Discovery 17, no. 7 (2020): 828–39. http://dx.doi.org/10.2174/1570180816666191024103534.

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Background:: Indole and pyrazoles are one of the prime structural units in the field of medicinal chemistry and have been reported to exhibit a variety of biological activities specifically anti-cancer. In view of their medicinal significance, we synthesized a conjugate of the two moieties to get access to newer and potential anti-cancer agents. Methods: Indolyl pyrazoles [3-(1,3-diphenyl-1H-pyrazol-4-yl)-2-(1-methyl-1H-indole-3-carbon yl)acrylonitriles] (4a-l) were synthesized by adopting simple and greener protocol and all the synthesized derivatives were docked against Bcl-2 protein and the

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14

Pires, Camila S., Daniela H. de Oliveira, Maria R. B. Pontel, et al. "Molecular iodine-catalyzed one-pot multicomponent synthesis of 5-amino-4-(arylselanyl)-1H-pyrazoles." Beilstein Journal of Organic Chemistry 14 (November 6, 2018): 2789–98. http://dx.doi.org/10.3762/bjoc.14.256.

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A one-pot iodine-catalyzed multicomponent reaction has been developed for the selective preparation of 5-amino-4-(arylselanyl)-1H-pyrazoles from a diverse array of benzoylacetonitriles, arylhydrazines and diaryl diselenides. The reactions were conducted in MeCN as solvent at reflux temperature under air. The methodology presents a large functional group tolerance to electron-deficient, electron-rich, and bulky substituents and gave the expected products in good to excellent yields. The synthesized 1,3-diphenyl-4-(phenylselanyl)-1H-pyrazol-5-amine was submitted to an oxidative dehydrogenative c

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15

Hayward, Emily R., Matthias Zeller, and Gellert Mezei. "Chiral versus achiral crystal structures of 4-benzyl-1H-pyrazole and its 3,5-diamino derivative." Acta Crystallographica Section E Crystallographic Communications 80, no. 7 (2024): 800–805. http://dx.doi.org/10.1107/s2056989024006182.

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The crystal structures of 4-benzyl-1H-pyrazole (C10H10N2, 1) and 3,5-diamino-4-benzyl-1H-pyrazole (C10H12N4, 2) were measured at 150 K. Although its different conformers and atropenantiomers easily interconvert in solution by annular tautomerism and/or rotation of the benzyl substituent around the C(pyrazole)—C(CH2) single bond (as revealed by 1H NMR spectroscopy), 1 crystallizes in the non-centrosymmetric space group P21. Within its crystal structure, the pyrazole and phenyl aromatic moieties are organized into alternating bilayers. Both pyrazole and phenyl layers consist of aromatic rings st

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16

Lynda, Golea. "Synthesis, DFT, Molecular docking Analysis and Antibacterial, Antioxidant Activities of tri-substituted pyrazoles." ASM Science Journal 16 (July 15, 2021): 1–7. http://dx.doi.org/10.32802/asmscj.2021.696.

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Pyrazole and its derivatives are contemplated crucial compounds in heterocyclic chemistry which are also used extensively in organic synthesis. These cycles are known for their biological and pharmacological activities. The present investigation is in the interest of some synthesized derivatives containing the pyrazole moieties. (5-Hydroxy-3,5-dimethyl-4,5-dihydro-pyrazol-1-yl)-pyridin-4-yl-methanone (1) and Furan-2-yl-(5-hydroxy-3,5-dimethyl-4,5-dihydro-pyrazol-1-yl)-methanone (2) were synthesized by cyclocondensation of the 1,3-dicarbonyl with the hydrazine derivative with a simple and rapid

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17

Srinivasa Reddy, T., Hitesh Kulhari, V. Ganga Reddy, et al. "Synthesis and biological evaluation of pyrazolo–triazole hybrids as cytotoxic and apoptosis inducing agents." Organic & Biomolecular Chemistry 13, no. 40 (2015): 10136–49. http://dx.doi.org/10.1039/c5ob00842e.

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A series of pyrazolo–triazole hybrids were designed and synthesized by combining the 1,3-diphenyl pyrazole and triazole scaffolds to obtain (1-benzyl-1H-1,2,3-triazol-4-yl)(1,3-diphenyl-1H-pyrazol-4-yl)methanones.

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18

B., SATHYA SURYANARAYANA, VENKATA RAMANA P., K. RAVINDRANATH L., SESHAGIRI V., and BRAHMAJI RAO S. "Electrochemical Behaviour of N '-Benzoyl-3,5-diphenyl- 4- (substituted-benzeneazo )pyrazoles." Journal of Indian Chemical Society Vol. 66, Nov 1989 (1989): 770–74. https://doi.org/10.5281/zenodo.5996467.

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Department of Chemistry, S. K. University, Anantapur-515 003 <em>Manuscript received 20 February 1989, revised 6 June 1989, accepted 21 June 1989</em> The electrochemical behaviour of <em>N</em>'-benzoyl-3,5-diphenyl-4-(substituted-benzene-azo)pyrazoles are studied in Britton-Robinson buffers (pH-2 '0 10.10) containing 6O% (v/v) dimethylformamide, using polarographic, voltammetric and millicoulometrc methods. All the compounds exhibited a well-defined 2-electron reduction wave at DME and a well-defined cathodic peak at HMDE. A plausible mechanism has been suggested on the basis of numb

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19

B., SATHYA SURYANARAYANA, VENKATA RAMANA P., K. RAVINDRANATH L., SESHAGIRI V., and BRAHMAJI RAO S. "Electrochemical Behaviour of N'-Benzoyl-3,5-diphenyl-4-(substituted-benzeneazo )pyrazoles." Journal of Indian Chemical Society Vol. 66, Nov 1989 (1989): 770–74. https://doi.org/10.5281/zenodo.6340133.

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Department of Chemistry, S. K. University, Anantapur-515 003 <em>Manuscript received 20 February 1989, revised 6 June 1989, accepted 21 June 1989</em> The electrochemical behaviour of <em>N'</em>-benzoyl-3,5-diphenyl-4-(substituted-benzeneazo)pyrazoles are studied in Britton—Robinson buffers (pH-2.10-10.10) containing (0.0% <em>(v/v) </em>dimethylformamide, using polarographic, voltammetric and millicoulometric methods. All the compounds exhibited a well-defined 2-electron reduction wave at DME and a well-defined cathodic peak at HMDE. A plausible mechanism has been suggest

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20

Kula, Karolina, Agnieszka Kącka-Zych, Agnieszka Łapczuk-Krygier, Zbigniew Wzorek, Anna K. Nowak, and Radomir Jasiński. "Experimental and Theoretical Mechanistic Study on the Thermal Decomposition of 3,3-diphenyl-4-(trichloromethyl)-5-nitropyrazoline." Molecules 26, no. 5 (2021): 1364. http://dx.doi.org/10.3390/molecules26051364.

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The present paper is a continuation of comprehensive study regarding to synthesis and properties of pyrazoles and their derivatives. In its framework an experimental and theoretical studies of thermal decomposition of the 3,3-diphenyl-4-(trichloromethyl)-5-nitropyrazoline were performed. It was found, that the decompositions of the mentioned pyrazoline system in the solution and at the melted state proceed via completely different molecular mechanisms. These mechanisms have been explained in the framework of the Molecular Electron Density Theory (MEDT) with the computational level of B3LYP/6-3

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21

Geethanjaly, N. S. "In-Silico Design, Synthesis and Evaluation of Some Pyrazolo Pyrazole Derivatives as Anticancer Agents." International Journal of Pharmacy and Biological Sciences (IJPBS) 14, no. 2 (2024): 73–82. https://doi.org/10.5281/zenodo.12789771.

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AbstractPyrazole is chemically known as 1,2-diazole and has become a popular topic of study. The chemistry of pyrazoles and its derivatives is particularly interesting because of their potential application in medicinal chemistry as analgesics, anti-inflammatory, antibacterial, antimalarial, antifungal, and as enzyme inhibitory agents The discovery of new drugs require not only its design and synthesis but also the development of testing method and procedures, which are needed to establish, how a substance operates in the body and its suitability for use as a drug. The aim of the study is to d

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22

Ben Soumane, Yahya, Abdesselam Baouid, El Mestafa El Hadrami, et al. "Synthesis, Characterization, Theoretical and Electrochemical Studies of Pyrazoline Derivatives." Mediterranean Journal of Chemistry 10, no. 9 (2020): 845. http://dx.doi.org/10.13171/mjc10902011121522ybs.

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<p class="Mabstract">The reaction of 1,3-dipolar cycloaddition of trans-anethole and three different diarylnitrilimines bearing different substituents X= {H, CH<sub>3</sub>, Cl} yield to the creation of three 1,3,4,5-tetrasubstituted pyrazoles. These reactions produce a single regioisomer. These compounds' structures were studied using diverse spectroscopic techniques such as <sup>1</sup>H, <sup>13</sup>C NMR, and HRMS. Afterwards, X-ray diffraction is performed at 5-(4-methoxyphenyl)-4-methyl-1,3-diphenyl-4,5-dihydro-1H-pyrazole. Also, Density Functio

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23

BONDAVALLI, F., O. BRUNO, A. RANISE, et al. "ChemInform Abstract: 3,5-Diphenyl-1H-pyrazole Derivatives. Part 6. Esters and 2- Dialkylaminoethyl Ethers of 1-(2-Hydroxy-2-phenylethyl)-3,5-diphenyl- 1H-pyrazole and N,N-Disubstituted 1-(2-Amino-2-phenylethyl)-3,5- diphenyl-1H-pyrazoles with Depressant a." ChemInform 22, no. 12 (2010): no. http://dx.doi.org/10.1002/chin.199112194.

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24

Perin, Gelson, Patrick Nobre, Daniela Mailahn та ін. "Synthesis of 4-Organoselanyl-1H-pyrazoles: Oxone®-Mediated Electrophilic Cyclization of α,β-Alkynyl Hydrazones by Using Diorganyl Diselenides". Synthesis 51, № 11 (2019): 2293–304. http://dx.doi.org/10.1055/s-0037-1611747.

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A simple and efficient method for the synthesis of 4‑organoselanyl-1H-pyrazoles has been developed, taking place under metal- and halogen-free conditions. Electrophilic species of selenium were easily generated in situ by the reaction of diorganyl diselenides with Oxone® in ethanol as solvent in an open-flask at 70 °C. These electrophilic selenium species were employed in the selenylation/cyclization of α,β-alkynyl hydrazones, giving the title compounds in moderate to excellent yields. The final species of selenium obtained from the reaction of diphenyl diselenide with Oxone® were characterize

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25

Gaikwad, R. N., and B.N. Chate. "Microwave Assisted One-Pot Multicomponent Synthesis of Amino Pyrazoles and its derivatives in Green Media." International Journal of Advance and Applied Research 5, no. 23 (2024): 380–84. https://doi.org/10.5281/zenodo.13637154.

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<strong>Abstract: </strong> A straightforward one-pot synthesis involving three components-5-amino-1,3-diphenyl-4,5-dihydro-1H-pyrazole-4-carbonitrile derivatives—was carried out under microwave radiation employing substituted aryl aldehyde, malononitrile, and phenyl hydrazine in catalytic amount of  baker’s yeast in water as a high performance at room temperature. The recently created approach has faster reaction times, higher quantitative yields, simpler product isolation, green reaction conditions, and a straightforward workup process. Using TLC, Melting point and spectrosc

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26

Rychlá, L., J. Rychlý, P. Ambrovič, K. Csomorová, L. Mögel, and M. Schulz. "Thermo-oxidative stability of polypropylene in the presence of substituted 3-anilino-1,5-diphenyl pyrazoles." Polymer Degradation and Stability 14, no. 2 (1986): 147–58. http://dx.doi.org/10.1016/0141-3910(86)90013-3.

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27

Zheng, Chang-Ji, Li-Li Xu, Liang-Peng Sun, Jing Miao, and Hu-Ri Piao. "Synthesis and antibacterial activity of novel 1,3-diphenyl-1H-pyrazoles functionalized with phenylalanine-derived rhodanines." European Journal of Medicinal Chemistry 58 (December 2012): 112–16. http://dx.doi.org/10.1016/j.ejmech.2012.10.012.

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BRUNO, O., A. RANISE, F. BONDAVALLI, et al. "ChemInform Abstract: 3,5-Diphenyl-1H-pyrazole Derivatives. Part 12. N-Substituted 4-Amino-1- (2-hydroxy- or 2-alkylaminoethyl)-3,5-diphenyl-1H-pyrazoles with Local Anesthetic, Analgesic and Platelet Antiaggregating Activities." ChemInform 26, no. 18 (2010): no. http://dx.doi.org/10.1002/chin.199518120.

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29

Zhang, Ze, Ya-Jun Tan, Chun-Shan Wang, and Hao-Hao Wu. "One-Pot Synthesis of 3,5-Diphenyl-1H-pyrazoles from Chalcones and Hydrazine under Mechanochemical Ball Milling." HETEROCYCLES 89, no. 1 (2014): 103. http://dx.doi.org/10.3987/com-13-12867.

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30

Ganapathi, M., D. Jayaseelan, and S. Guhanathan. "Microwave assisted efficient synthesis of diphenyl substituted pyrazoles using PEG-600 as solvent – A green approach." Ecotoxicology and Environmental Safety 121 (November 2015): 87–92. http://dx.doi.org/10.1016/j.ecoenv.2015.05.002.

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31

Palanisamy, Pandaram, and Sudalaiandi Kumaresan. "Tricyclic Pyrazoles: Synthesis, Characterization, Antimicrobial, Antituberculosis, and Antitumor Activity of N,1-Diphenyl-1,4-dihydrothiochro-meno[4,3-c]pyrazole-3-carboxamide-5,5-dioxide Derivatives." British Journal of Pharmaceutical Research 4, no. 14 (2014): 1802–19. http://dx.doi.org/10.9734/bjpr/2014/6155.

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32

Abeed, Ahmed A. O., Talaat I. El-Emary, and Mohamed S. K. Youssef. "A Facile Synthesis and Reactions of Some Novel Pyrazole-based Heterocycles." Current Organic Synthesis 16, no. 3 (2019): 405–12. http://dx.doi.org/10.2174/1570179416666181210160908.

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<p>Aim and Objective: This work presents the synthetic capability and the exploitation of 1,3-diphenyl- 1H-pyrazole-4-carboxladehyde 1 and 5-diphenyl pyrazolyl-2-pyrazoline analogue 8 to serve as excellent precursors for the synthesis of substituted indol-2,3-dione, trizolo[3,4-a]benzazoles, thiazolo[2,3- a]benzimidazole-3-one, substituted 2-pyrazoline and pyrazole-substituted-pyrazolines using various reagents. </P><P> Materials and Methods: Using chemicals from Aldrich, Fluka, or Merck, and pure solvents, we apply the synthetic procedures for the synthesis of novel heterocy

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Veeranki, Krishna Chaitanya, Jalapathi Pochampally, Ravi Chandar Maroju, and Vishnu Thumma. "Synthesis of Novel 4-(3-nitro-2H-chromen-2-yl)-1,3-diphenyl-1H-pyrazole analogues." Research Journal of Chemistry and Environment 27, no. 2 (2023): 35–38. http://dx.doi.org/10.25303/2702rjce035038.

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In this study, we report the synthesis of a library of new 4-(3-nitro-2H-chromen-2-yl)-1,3-diphenyl-1H-pyrazol e analogues. Condensation of pyrazole carbaldehyde precursor with nitromethane yielded (E)-4-(2-nitrovinyl)-1,3-diphenyl-1H-pyrazole intermediate. This intermediate upon intermolecular cyclization with substituted salicylaldehydes individually, produced 4-(3-nitro-2H-chromen-2-yl)-1,3-diphenyl-1H-pyrazole analogues. The structures of compounds were confirmed by the interpretation of 1H-NMR, 13C-NMR and Mass spectral analysis.

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34

Zhang, Ze, Ya-Jun Tan, Chun-Shan Wang, and Hao-Hao Wu. "ChemInform Abstract: One-Pot Synthesis of 3,5-Diphenyl-1H-pyrazoles from Chalcones and Hydrazine under Mechanochemical Ball Milling." ChemInform 45, no. 24 (2014): no. http://dx.doi.org/10.1002/chin.201424132.

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35

Addoum, Boutaina, Bouchra El khalfi, Mohamed Idiken, et al. "Synthesis, Characterization of Pyrano-[2,3-c]-Pyrazoles Derivatives and Determination of Their Antioxidant Activities." Iranian Journal of Toxicology 15, no. 3 (2021): 175–94. http://dx.doi.org/10.32598/ijt.15.3.798.1.

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Background: Antioxidants are developed to assist the immune system and overcome oxidative stress, the aggression of cellular constituents due to imbalance between reactive oxygen species and the inner antioxidant system. The main objective of this study was to search for new and potent antioxidants to protect humans against diseases associated with oxidative stress. Methods: In this study, three pyrano-[2,3-c]-pyrazole derivatives were synthesized via Multicomponent Reaction (MCR) approach and were characterized, using a melting point, High-Performance Liquid Chromatography (HPLC), and spectro

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36

Fioravanti, Rossella, Nicoletta Desideri, Mariangela Biava, Luca Proietti Monaco, Laura Grammatica, and Matilde Yáñez. "Design, synthesis, and in vitro hMAO-B inhibitory evaluation of some 1-methyl-3,5-diphenyl-4,5-dihydro-1H-pyrazoles." Bioorganic & Medicinal Chemistry Letters 23, no. 18 (2013): 5128–30. http://dx.doi.org/10.1016/j.bmcl.2013.07.035.

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37

Pathak, Vinay, Hardesh K. Maurya, Sandeep Sharma, Kishore K. Srivastava, and Atul Gupta. "Synthesis and biological evaluation of substituted 4,6-diarylpyrimidines and 3,5-diphenyl-4,5-dihydro-1H-pyrazoles as anti-tubercular agents." Bioorganic & Medicinal Chemistry Letters 24, no. 13 (2014): 2892–96. http://dx.doi.org/10.1016/j.bmcl.2014.04.094.

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38

Vasin, V. A., V. V. Razin, E. V. Bezrukova, and P. S. Petrov. "Regioselectivity of the thermal van Alphen–Hüttel rearrangement of 4- and 5-mono- and 4,5-disubstituted 3,3-diphenyl-3H-pyrazoles." Russian Journal of Organic Chemistry 52, no. 6 (2016): 862–72. http://dx.doi.org/10.1134/s1070428016060178.

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39

Menozzi, Giulia, Luisa Merello, Paola Fossa, et al. "Synthesis, antimicrobial activity and molecular modeling studies of halogenated 4-[1H-imidazol-1-yl(phenyl)methyl]-1,5-diphenyl-1H-pyrazoles." Bioorganic & Medicinal Chemistry 12, no. 20 (2004): 5465–83. http://dx.doi.org/10.1016/j.bmc.2004.07.029.

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40

Spencer, Lara C., Ilia A. Guzei, Tebogo V. Segapelo, and James Darkwa. "1,2-Bis[(3,5-diphenyl-1H-pyrazol-1-yl)methyl]benzene." Acta Crystallographica Section E Structure Reports Online 68, no. 8 (2012): o2584. http://dx.doi.org/10.1107/s1600536812032801.

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The title compound, C38H30N4, a potentially mono- and bidentate ligand, does not seem to form palladium complexes similar to other poly(pyrazol-1-ylmethyl)benzenes due to the large steric size of the phenyl substituents on the pyrazole rings. The pyrazole rings have a 21.09 (5)° angle between their mean planes and exhibit atrans-like geometry in which the in-plane lone pairs of electrons on the 2-N nitrogen atoms point in opposite directions.

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41

Shawali, Ahmad Sami, Mahmoud H. Abdelkader, and Farag M. A. Eltalbawy. "Synthesis and tautomeric structure of novel 3,7-bis(arylazo)-2,6-diphenyl-1H-imidazo-[1,2-b]pyrazoles in ground and excited states." Tetrahedron 58, no. 14 (2002): 2875–80. http://dx.doi.org/10.1016/s0040-4020(02)00157-6.

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42

Khan, Taukeer A., Sarvesh Kumar, Chelvam Venkatesh, and Hiriyakkanavar Ila. "Regioselective rapid analog synthesis of 1,3-(or 1,5-)diphenyl-4-aryl/heteroaryl-5-(or 3-)(methylthio)pyrazoles via Suzuki cross-coupling." Tetrahedron 67, no. 16 (2011): 2961–68. http://dx.doi.org/10.1016/j.tet.2011.02.043.

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43

Yen, Yao-Pin, Tseng-Min Huang, Yu-Ping Tseng, Hsuan-Yu Lin, and Ching-Cheng Lai. "Photoinduced Electron Transfer Reactions of 3,3-Dialkylated 4,5-Diphenyl-3H-Pyrazoles: A New Route to the Formation of the Solvent Adducts." Journal of the Chinese Chemical Society 51, no. 2 (2004): 393–98. http://dx.doi.org/10.1002/jccs.200400061.

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44

Fioravanti, Rossella, Nicoletta Desideri, Mariangela Biava, Luca Proietti Monaco, Laura Grammatica, and Matilde Yanez. "ChemInform Abstract: Design, Synthesis, and in vitro hMAO-B Inhibitory Evaluation of Some 1-Methyl-3,5-diphenyl-4,5-dihydro-1H-pyrazoles." ChemInform 45, no. 4 (2014): no. http://dx.doi.org/10.1002/chin.201404127.

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45

Deepa, M., V. Harinadha Babu, R. Parameshwar, and B. Madhava Reddy. "Synthesis of 3-(1, 3-Diphenyl-1H-pyrazol-4-yl) Propanoic Acids Using Diimide Reduction." E-Journal of Chemistry 9, no. 1 (2012): 420–24. http://dx.doi.org/10.1155/2012/481682.

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Pyrazole-1H-4-yl-acrylic acids (3a-j) were prepared from pyrazole-1H-4-carbaldehydes which in turn were prepared by the Vilsmeier-Haack reaction of phenyl hydrazone derivatives (1a-j). The reaction of pyrazole-1H-4-yl-acrylic acids to 3-(1, 3-diphenyl-1H-pyrazol-4-yl) propanoic acids (4a-j) was carried out using Pd-charcoal and diimide methods and % yields were compared. Though the yields may be slightly less in diimide method, the method was found to be economical, highly effective with simple operating procedure.

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46

Vasin, V. A., V. V. Razin, E. V. Bezrukova, D. Yu Korovin, P. S. Petrov, and N. V. Somov. "Synthesis of 3,3-diphenyl-3H-pyrazoles applying vinyl sulfones as chemical equivalents of acetylenes in reaction of 1,3-dipolar cycloaddition to diphenyldiazomethane." Russian Journal of Organic Chemistry 51, no. 8 (2015): 1144–54. http://dx.doi.org/10.1134/s1070428015080138.

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47

Kasimogullari, Rahmi, Belma Zengin, Makbule Maden, Samet Mert, and Cavit Kazaz. "Synthesis of new derivatives of 1-(3-amino-phenyl)-4- benzoyl-5-phenyl-1h-pyrazole-3-carboxylic acid." Journal of the Serbian Chemical Society 75, no. 12 (2010): 1625–35. http://dx.doi.org/10.2298/jsc101018135k.

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4-Benzoyl-1-(3-aminophenyl)-5-phenyl-1H-pyrazole-3- carboxylic acid (1) was synthesized according to the literature.1 2-(3- Aminophenyl)-3,4-diphenyl-2H-pyrazolo[3,4-d]pyridazin-7(6H)-one (5) was obtained by the cyclocondensation reaction of 1 with hydrazine hydrate. New pyrazole derivatives of compounds 1 and 5 were synthesized by their reaction with ?-diketones, ?-ketoesters, ?-naphthol, phenol and various other reagents. The structures of the synthesized compounds were characterized by 1H-NMR, 13C-NMR, IR and Mass spectroscopy, as well as elemental analysis.

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48

Sowbhagyam, D. Valli, D. Koteswararao, and Dr K. Prameela. "Ionic Liquid Mediated Synthesis and Anticancer Activity of 5-((1, 3-DIPHENYL-1H-PYRAZOL-4-YL) METHYLENE) THIAZOLIDINE-2, 4-DIONES." International Journal for Research in Applied Science and Engineering Technology 11, no. 9 (2023): 200–204. http://dx.doi.org/10.22214/ijraset.2023.55627.

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Abstract: A series of 5-((1,3-diphenyl-1H-pyrazol-4-yl)methylene)thiazolidine-2,4-dione derivatives were synthesised by the Claisen-Schmidt condensation of 1,3-diphenyl-1H-pyrazole-4-carbaldehyde with thiazolidine-2,4-dione using Ionic liquid under both conventional heating method and microwave irradiation method. All the synthesised derivatives were screened for their anticancer activity against three different human cell lines as cervix (SiHa), brest (MDA-MB-231) and pancreatic carcinoma (PANC-1) using the Sulforhodamine B assay method.

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49

Gökşen, Umut Salgın, Yelda Bingöl Alpaslan, Nesrin Gökhan Kelekçi, Şamil Işık, and Melike Ekizoğlu. "Synthesis, crystal structures and theoretical calculations of new 1-[2-(5-chloro-2-benzoxazolinone-3-yl)acetyl]-3,5-diphenyl-4,5-dihydro-(1H)-pyrazoles." Journal of Molecular Structure 1039 (May 2013): 71–83. http://dx.doi.org/10.1016/j.molstruc.2013.01.066.

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50

Khan, Taukeer A., Sarvesh Kumar, Chelvam Venkatesh, and Hiriyakkanavar Ila. "ChemInform Abstract: Regioselective Rapid Analogue Synthesis of 1,3-(or 1,5-)Diphenyl-4-aryl/heteroaryl-5-(or 3-)(methylthio)pyrazoles via Suzuki Cross-Coupling." ChemInform 42, no. 34 (2011): no. http://dx.doi.org/10.1002/chin.201134117.

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