Log in

Relevant bibliographies by topics / Diphtheria / Journal articles

To see the other types of publications on this topic, follow the link: Diphtheria.

Journal articles on the topic 'Diphtheria'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Diphtheria.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Schirmer, Patricia, Cynthia A. Lucero-Obusan, Aditya Sharma, Gina Oda, and Mark Holodniy. "1201. Diphtheria in Veterans Health Administration (VHA), 2000-2021." Open Forum Infectious Diseases 8, Supplement_1 (2021): S692. http://dx.doi.org/10.1093/ofid/ofab466.1393.

Full text

Abstract:

Abstract Background Diphtheria is caused by Corynebacterium diphtheriae and can cause respiratory or skin infections. Transmission occurs primarily person-to-person via respiratory tract and rarely from skin lesions or fomites. In the Veterans Health Administration (VHA), we perform surveillance for nationally notifiable diseases such as diphtheria. In early 2021, there were 4 alerts for C. diphtheriae. Therefore, we investigated diphtheria prevalence in VHA over the last 20 years. Methods Isolates of C. diphtheriae were identified from VHA data sources from 1/1/2000-2/28/2021. Patient demogra

APA, Harvard, Vancouver, ISO, and other styles

2

Chagina, I. A., O. Yu Borisova, L. I. Kafarskaya, et al. "COMPOSITION OF POPULATION OF DIPHTHERIA CAUSATIVE AGENT STRAINS IN RUSSIA." Journal of microbiology, epidemiology and immunobiology 93, no. 5 (2016): 50–60. http://dx.doi.org/10.36233/0372-9311-2016-5-50-60.

Full text

Abstract:

Aim. Characteristics of clonal composition of Corynebacterium diphtheriae strain populatior in Russia using MLST, as well as evaluation of a possibility of using of this method during execution of monitoring of diphtheria infection causative agent strains. Materials and methods. C. diphtheriae strains, isolated in Russia in 1957 - 2015 and sent to Gabrichevsky MRIEM reference centre for diphtheria and pertussis, were studied. Genotyping of C. diphtheriae using MLST wa: carried out based on sequencing of «housekeeping» gene fragments. ST identification was carriec out according to PubMLST. Resu

APA, Harvard, Vancouver, ISO, and other styles

3

Alfiansyah, Gamasiano. "PENYELIDIKAN EPIDEMIOLOGI KEJADIAN LUAR BIASA (KLB) DIFTERI DI KABUPATEN BLITAR TAHUN 2015." Preventia : The Indonesian Journal of Public Health 2, no. 1 (2017): 37. http://dx.doi.org/10.17977/um044v2i1p37-42.

Full text

Abstract:

ABSTRAK Difteri merupakan penyakit menular mematikan yang menyerang saluran pernapasan atas yang disebabkan oleh bakteri Corynebacterium diphtheriae. Kasus difteri di Kabupaten Blitar cenderung meningkat dari tahun ke tahun. Jumlah kasus tahun 2011 sebanyak 15 kasus, tahun 2012 sebanyak 23 kasus, tahun 2013 sebanyak 17 kasus, tahun 2014 sebanyak 21 kasus, dan tahun 2015 sebanyak 38 kasus dengan jumlah kasus tertinggi di kecamatan Kanigoro sebanyak 9 kasus. Tujuan penyelidikan epidemiologi adalah mengetahui besar masalah KLB difteri dan faktor risiko yang mempengaruhinya.Jenis penelitian adalah

APA, Harvard, Vancouver, ISO, and other styles

4

Tok, Peter Seah Keng, Misbaha Jilani, Nurul Fateha Misnar, Nor Suzila Bidin, Norli Rosli, and Haidar Rizal Toha. "A diphtheria outbreak in Johor Bahru, Malaysia: Public health investigation and response." Journal of Infection in Developing Countries 16, no. 07 (2022): 1159–65. http://dx.doi.org/10.3855/jidc.16076.

Full text

Abstract:

Introduction: Diphtheria is an acute infectious disease caused by Corynebacterium diphtheriae. Although the incidence of diphtheria worldwide has rapidly declined following the largely successful diphtheria toxoid-based vaccines, concerns persist for those who were unvaccinated or incompletely vaccinated. In this report, we describe a recent diphtheria outbreak in Malaysia involving four confirmed diphtheria cases. Methodology: The outbreak investigation efforts and epidemiological characteristics of a diphtheria outbreak in Malaysia are described. For all suspected cases, swabs were tak

APA, Harvard, Vancouver, ISO, and other styles

5

Truelove, Shaun A., Lindsay T. Keegan, William J. Moss, et al. "Clinical and Epidemiological Aspects of Diphtheria: A Systematic Review and Pooled Analysis." Clinical Infectious Diseases 71, no. 1 (2019): 89–97. http://dx.doi.org/10.1093/cid/ciz808.

Full text

Abstract:

Abstract Background Diphtheria, once a major cause of childhood morbidity and mortality, all but disappeared following introduction of diphtheria vaccine. Recent outbreaks highlight the risk diphtheria poses when civil unrest interrupts vaccination and healthcare access. Lack of interest over the last century resulted in knowledge gaps about diphtheria’s epidemiology, transmission, and control. Methods We conducted 9 distinct systematic reviews on PubMed and Scopus (March–May 2018). We pooled and analyzed extracted data to fill in these key knowledge gaps. Results We identified 6934 articles,

APA, Harvard, Vancouver, ISO, and other styles

6

Kostyukova, N. N., and V. A. Bechalo. "Diphtheria Carriage." Epidemiology and Vaccine Prevention 17, no. 5 (2018): 60–70. http://dx.doi.org/10.31631/2073-3046-2018-17-5-60-70.

Full text

Abstract:

The diphtheria carriage is a asympthomatic colonization of oro- and nasopharynx by toxigenic and nontoxigenic Corynebacterium diphtheriae. The carriage of toxigenic strains prevents a complete eradication of diphtheria infection in spite of mass toxoid immunization. The contamination by toxigenic diphtheria bacteria leads to the carriage if the person has a protective level of diphtheria antitoxin. Contamination with the toxigenic and nontoxigenic leads to the carriage if the person has no protection to the bacterial colonization factors. Some of them are surface protein structures and may ser

APA, Harvard, Vancouver, ISO, and other styles

7

Ott, Lisa, Jens Möller, and Andreas Burkovski. "Interactions between the Re-Emerging Pathogen Corynebacterium diphtheriae and Host Cells." International Journal of Molecular Sciences 23, no. 6 (2022): 3298. http://dx.doi.org/10.3390/ijms23063298.

Full text

Abstract:

Corynebacterium diphtheriae, the etiological agent of diphtheria, is a re-emerging pathogen, responsible for several thousand deaths per year. In addition to diphtheria, systemic infections, often by non-toxigenic strains, are increasingly observed. This indicates that besides the well-studied and highly potent diphtheria toxin, various other virulence factors may influence the progression of the infection. This review focuses on the known components of C. diphtheriae responsible for adhesion, invasion, inflammation, and cell death, as well as on the cellular signaling pathways activated upon

APA, Harvard, Vancouver, ISO, and other styles

8

Prygiel, Marta, Maciej Polak, Ewa Mosiej, Karol Wdowiak, Kamila Formińska, and Aleksandra Anna Zasada. "New Corynebacterium Species with the Potential to Produce Diphtheria Toxin." Pathogens 11, no. 11 (2022): 1264. http://dx.doi.org/10.3390/pathogens11111264.

Full text

Abstract:

Only three Corynebacterium species are known to produce a lethal exotoxin called diphtheria toxin. These are C. diphtheriae, C. ulcerans and C. pseudotuberculosis. The diphtheria toxin gene (tox) is carried in a family of closely related corynebacteriophages and therefore the toxin can be produced only through lysogenisation, in which the corynephage encoding tox is stably inserted into the chromosome. However, ‘nontoxigenic tox gene-bearing’ (NTTB) strains, which are genotypically tox-positive but do not express the protein, have been described. The emergence of NTTB strains was first observe

APA, Harvard, Vancouver, ISO, and other styles

9

Efstratiou, Androulla, Kathryn H. Engler, Charlotte S. Dawes, and Dorothea Sesardic. "Comparison of Phenotypic and Genotypic Methods for Detection of Diphtheria Toxin among Isolates of Pathogenic Corynebacteria." Journal of Clinical Microbiology 36, no. 11 (1998): 3173–77. http://dx.doi.org/10.1128/jcm.36.11.3173-3177.1998.

Full text

Abstract:

We have compared molecular, immunochemical, and cytotoxic assays for the detection of diphtheria toxin from 55 isolates ofCorynebacterium diphtheriae and Corynebacterium ulcerans originally isolated in five different countries. The suitabilities and accuracies of these assays for the laboratory diagnosis of diphtheria were compared and evaluated against the “gold standard” in vivo methods. The in vivo and Vero cell cytotoxicity assays were accurate in their abilities to detect diphtheria toxin but were time-consuming; however, the cytotoxicity assay is a suitable in vitro alternative to the in

APA, Harvard, Vancouver, ISO, and other styles

10

Febriyana, Dwi, Sunarno Sunarno, Yudi Hartoyo, et al. "Analisis Gen Tox Corynebacterium Diphtheriae Penyebab Difteri di Beberapa Wilayah Indonesia." Buletin Penelitian Kesehatan 49, no. 1 (2021): 63–70. http://dx.doi.org/10.22435/bpk.v0i0.3844.

Full text

Abstract:

Diphtheria is a vaccine-preventable disease. The clinical features and complications of diphtheria are associated with toxins produced by the causative bacteria. Diphtheria toxin synthesis is encoded by tox gene. This study aimed to provide an overview of the DNA sequences of the tox gene of Corynebacterium diphtheriae causing diphtheria in several region of Indonesia. A total of 65 Corynebacterium diphtheriae isolated from several provinces in Indonesia (2010-2017) were used as samples. Isolates recultured on blood agar medium (BA), incubated at 37 0 C overnight. DNA extraction conducted usin

APA, Harvard, Vancouver, ISO, and other styles

11

Febriyana, Dwi, Sunarno Sunarno, Yudi Hartoyo, et al. "Analisis Gen Tox Corynebacterium Diphtheriae Penyebab Difteri di Beberapa Wilayah Indonesia." Buletin Penelitian Kesehatan 49, no. 1 (2021): 63–70. http://dx.doi.org/10.22435/bpk.v49i1.3844.

Full text

Abstract:

Diphtheria is a vaccine-preventable disease. The clinical features and complications of diphtheria are associated with toxins produced by the causative bacteria. Diphtheria toxin synthesis is encoded by tox gene. This study aimed to provide an overview of the DNA sequences of the tox gene of Corynebacterium diphtheriae causing diphtheria in several region of Indonesia. A total of 65 Corynebacterium diphtheriae isolated from several provinces in Indonesia (2010-2017) were used as samples. Isolates recultured on blood agar medium (BA), incubated at 37 0 C overnight. DNA extraction conducted usin

APA, Harvard, Vancouver, ISO, and other styles

12

Oguntolu, Festus Abiodun, Olumuyiwa James Peter, Benjamin Idoko Omede, Ghaniyyat Bolanle Balogun, Aminat Olabisi Ajiboye, and Hasan S. Panigoro. "Mathematical Modeling on the Transmission Dynamics of Diphtheria with Optimal Control Strategies." Jambura Journal of Biomathematics (JJBM) 6, no. 1 (2025): 1–22. https://doi.org/10.37905/jjbm.v6i1.29716.

Full text

Abstract:

Diphtheria is an acute bacterial infection caused by Corynebacterium diphtheriae, characterized by the formation of a pseudo-membrane in the throat, which can lead to airway obstruction and systemic complications. Despite the availability of effective vaccines, diphtheria remains a significant public health concern in many regions, particularly in areas with low immunization coverage. In this study, we formulated and rigorously analyzed a deter ministic epidemiological mathematical model to gain insight into the transmission dynamics of Diphtheria infection, incorporating the concentration of

APA, Harvard, Vancouver, ISO, and other styles

13

Mutahhar, Alif, and Dwiyanti Puspitasari. "SENSITIVITY OF ERYTHROMYCIN AGAINST CORYNEBACTERIUM DIPHTHERIAE." Indonesian Journal of Tropical and Infectious Disease 8, no. 1 (2020): 16. http://dx.doi.org/10.20473/ijtid.v8i1.11654.

Full text

Abstract:

Diphtheria is an acute infection disease caused by Corynebacterium diphtheriae. It remains a problem in Indonesia in a recent several years especially in East Java Province, which suffered from an outbreak of diphtheria in 2011. Erythromycin is the second line antibiotics therapy for diphteria if the patient is allergic to penicillin, also serving as a prophylactic and carrier therapy for contact diphtheria. Erythromycin has been used for diphtheria for a very long time, but there is little recent data on its sensitivity against C. diphtheriae. The purpose of this study is to identify whether

APA, Harvard, Vancouver, ISO, and other styles

14

Sunarno, Sunarno, Yuanita Mulyastuti, Nelly Puspandari, and Kambang Sariadji. "DNA Sequence Analysis of dtxR Gene (Partial) of Corynebacterium diphtheriae Causing Diphtheria in Jawa and Kalimantan Islands, Indonesia." Indonesian Biomedical Journal 9, no. 2 (2017): 91. http://dx.doi.org/10.18585/inabj.v9i2.268.

Full text

Abstract:

BACKGROUND: dtxR gene is a global regulator that can be used as a marker for detection of Corynebacterium diphtheriae (C. diphtheriae) and it is also a representative tool for mapping purpose (molecular typing) of this bacteria. The aim of this study was to analyze the DNA sequences of partial dtxR gene of C. diphtheriae causing diphtheria in some region of Indonesia. DNA sequence analysis was used to verify the accuracy of the in-house multiplex polymerase chain reaction (PCR) method that used for detection of C. diphtheriae in the clinical specimen as well as a preliminary study to determine

APA, Harvard, Vancouver, ISO, and other styles

15

Ariwinanti, Desy, Nurnaningsih Herya Ulfa, and Lucky Radita Alma. "BONEKA PANGGUNG DAN BUKU SAKU BERGAMBAR SEBAGAI MEDIA PROMOSI KESEHATAN TENTANG DIFTERI DAN IMUNISASI PADA SISWA TK DAN SD DI KOTA MALANG." Preventia : The Indonesian Journal of Public Health 3, no. 2 (2018): 136. http://dx.doi.org/10.17977/um044v3i2p136-142.

Full text

Abstract:

Abstrak : Difteri atau Diphtheria adalah suatu penyakit infeksi akut yang disebabkan oleh toksin yang diproduksi oleh Corynebacterium diphtheriae. Angka kejadian difteri di Indonesia terus meningkat, pada 2016 terjadi 415 kasus dengan 24 kematian, Case Fatality Rate (CFR) 5.8%. Di Kota Malang sepanjang 2017 ditemukan 19 kasus terutama di sekolah dasar hingga menengah yang belum mendapat imunisasi (Arifin, 2017). Boneka Panggung dan Buku Saku Bergambar merupakan media promosi kesehatan yang dapat digunakan sebagai media untuk mengenalkan difteri dan meningkatkan sikap positif terhadap imunisasi

APA, Harvard, Vancouver, ISO, and other styles

16

Dragomirescu, Cerasella Cristiana, and Mădălina Preda. "DIPHTHERIA IN EUROPEAN COUNTRIES BY 2010-2022." Romanian Archives of Microbiology and Immunology 82, no. 2 (2023): 124–31. http://dx.doi.org/10.54044/rami.2023.02.06.

Full text

Abstract:

Diphtheria is a serious, potentially fatal infectious disease in susceptible individuals. Diphtheria is caused by the toxin produced by strains of Corynebacterium diphtheriae and/or C. ulcerans or C. pseudotuberculosis. The number of cases of diphtheria is relatively low in many European countries due to the functioning of vaccination programs, but diphtheria may now return due to the increase in the number of unvaccinated people, largely due to the increase in refusal and population migration. We would like to draw attention to the phenomenon described in Europe that can also manifest itself

APA, Harvard, Vancouver, ISO, and other styles

17

Kambang, Sariadji, and Hendro Putranto Rudi. "A Fatal Diphtheria Case in a 4-Years-Old Child with Protective Diphtheria IgG Antibody in 2014." International Journal of Science and Healthcare Research 5, no. 1 (2020): 198–203. https://doi.org/10.5281/zenodo.3930306.

Full text

Abstract:

<strong>Background: </strong>Basic Health Research Data 2010 show that the coverage of basic complete immunization was 48.8%. The lower of Immunization coverage will lead to vulnerability of diphtheria. A case of diphtheria was reported in the Regional General Hospital of Serang Banten, in a 4-years-old boy with symptoms of fever, difficulty swallowing, breathing and bullneck onset. The next day after sampling of throat swab, nose swab and blood, the patient died. <strong>Objective.</strong> This study aims to identify the cause of death of patients with suspected diphtheria based on

APA, Harvard, Vancouver, ISO, and other styles

18

Kharseeva, Galina Georgievna, A. A. Alieva, L. P. Alekseeva, Ye O. Mangutov, and L. A. Shovkun. "CYPOPATHIC EFFECT OF DIPHTHERIA PATHOGEN IN THE COMPOSITION OF BIOFILM." Russian Clinical Laboratory Diagnostics 64, no. 11 (2019): 681–85. http://dx.doi.org/10.18821/0869-2084-2019-64-11-681-685.

Full text

Abstract:

When the nasopharynx is colonized with toxigenic strains of the diphtheria pathogen, toxin is released, which contributes to the death of epithelial cells. But in bacterial carriers, the development of the clinical picture of the disease does not occur. This is due to the peculiarities of the state of their immune system, as well as the peculiarities of the production of diphtheria exotoxin by corynebacteria in the biofilm. Goal. Determining the nature of the cytopathic effect of C. diphtheriae as part of a biofilm in CHO-K1 cell culture. The planktonic and biofilm (120- and 720-hour) cultures

APA, Harvard, Vancouver, ISO, and other styles

19

Tchorbanov, Andrey I., Jordan D. Dimitrov, and Tchavdar L. Vassilev. "Optimization of casein-based semisynthetic medium for growing of toxigenic Corinebacterium diphtheriae in a fermenter." Canadian Journal of Microbiology 50, no. 10 (2004): 821–26. http://dx.doi.org/10.1139/w04-061.

Full text

Abstract:

Diphtheria toxin is produced by growing Corinebacterium diphtheriae either in a semisynthetic casein-based medium or in the Pope–Lingood meat extract based medium. The World Health Organization advises the use of the semisynthetic one, as it has important advantages. Data on the composition of casein-based media and their ability to support high toxin production are not freely available. Important factors affecting toxin production during C. diphtheriae cultivation are the pH of the culture medium and the concentration of casein hydrolysate and of Fe2+. We established that the optimal pH for t

APA, Harvard, Vancouver, ISO, and other styles

20

Dugbor, Muekara Friday. "The Diphtheria Disease." International Journal of Advances in Scientific Research and Engineering 10, no. 02 (2024): 12–28. http://dx.doi.org/10.31695/ijasre.2024.2.2.

Full text

Abstract:

This study, ‘The Diphtheria Disease’ explored the historical significance, etiology, symptoms, transmission, and preventive measures related to diphtheria. The study adopted a qualitative meta-analysis approach. The objectives were threefold, which included to ascertain the cause(s) of diphtheria, to investigate potential cures, and to determine the efficacy of treatments. The narrative unfolded through an examination of historical outbreaks, breakthroughs, and contemporary challenges. The study focused on respiratory, cutaneous, nasal, laryngeal, and pharyngeal diphtheria types, detailing sym

APA, Harvard, Vancouver, ISO, and other styles

21

Poudel, Binod, Aastha Lamsal, and Chandra M. Poudel. "High mortality diphtheritic myocarditis with conduction disturbance, case series, and review of literature." Annals of Medicine & Surgery 85, no. 8 (2023): 3797–800. http://dx.doi.org/10.1097/ms9.0000000000001037.

Full text

Abstract:

Introduction: Diphtheria cases are still being reported in various parts of the globe. Although complete heart block resulting from diphtheric myocarditis is infrequent, it can lead to fatality. Awareness and recognition of this help strengthen the importance of vaccines and their proper management. Case presentation: The authors report two young patients who presented in the interval of a month, to the emergency department with signs and symptoms of diphtheria. Both developed diphtheric myocarditis with complete heart block and severe left ventricular systolic dysfunction, which did not respo

APA, Harvard, Vancouver, ISO, and other styles

22

Schlez, Karen, Tobias Eisenberg, Jörg Rau, et al. "Corynebacterium rouxii, a recently described member of the C. diphtheriae group isolated from three dogs with ulcerative skin lesions." Antonie van Leeuwenhoek 114, no. 9 (2021): 1361–71. http://dx.doi.org/10.1007/s10482-021-01605-8.

Full text

Abstract:

AbstractCorynebacterium (C.) diphtheriae is one of the two etiological pathogens for human diphtheria with significant morbidity and mortality. Recently, members of its biovar Belfanti have been described as two novel species, C. belfantii and C. rouxii. The most important virulence factor and also the premise to cause diphtheria is the isolate’s capacity to encode and express the diphtheria toxin (DT). In contrast to C. ulcerans, which represents a potentially zoonotic pathogen, C. diphtheriae (incl. the novel deduced species) has almost exclusively been found to comprise a human pathogen. We

APA, Harvard, Vancouver, ISO, and other styles

23

Oram, Diana Marra, Ana Avdalovic, and Randall K. Holmes. "Construction and Characterization of Transposon Insertion Mutations in Corynebacterium diphtheriae That Affect Expression of the Diphtheria Toxin Repressor (DtxR)." Journal of Bacteriology 184, no. 20 (2002): 5723–32. http://dx.doi.org/10.1128/jb.184.20.5723-5732.2002.

Full text

Abstract:

ABSTRACT Transcription of the bacteriophage-borne diphtheria toxin gene tox is negatively regulated, in response to intracellular Fe2+ concentration, by the chromosomally encoded diphtheria toxin repressor (DtxR). Due to a scarcity of tools, genetic analysis of Corynebacterium diphtheriae has primarily relied on analysis of chemically induced and spontaneously occurring mutants and on the results of experiments with C. diphtheriae genes cloned in Escherichia coli or analyzed in vitro. We modified a Tn5-based mutagenesis technique for use with C. diphtheriae, and we used it to construct the fir

APA, Harvard, Vancouver, ISO, and other styles

24

Devanga Ragupathi, Naveen Kumar, Dhiviya Prabaa Muthuirulandi Sethuvel, Dhivya Murugan, et al. "Divergent evolution of Corynebacterium diphtheriae in India: An update from National Diphtheria Surveillance network." PLOS ONE 16, no. 12 (2021): e0261435. http://dx.doi.org/10.1371/journal.pone.0261435.

Full text

Abstract:

Diphtheria is caused by a toxigenic bacterium Corynebacterium diphtheria which is being an emerging pathogen in India. Since diphtheria morbidity and mortality continues to be high in the country, the present study aimed to study the molecular epidemiology of C. diphtheriae strains from India. A total of 441 diphtheria suspected specimens collected as part of the surveillance programme between 2015 and 2020 were studied. All the isolates were confirmed as C. diphtheriae with standard biochemical tests, ELEK’s test, and real-time PCR. Antimicrobial susceptibility testing for the subset of isola

APA, Harvard, Vancouver, ISO, and other styles

25

Hamabata, Takashi, Mitsutoshi Senoh, Masaaki Iwaki, Ayae Nishiyama, Akihiko Yamamoto, and Keigo Shibayama. "Induction and Resuscitation of Viable but Nonculturable Corynebacterium diphtheriae." Microorganisms 9, no. 5 (2021): 927. http://dx.doi.org/10.3390/microorganisms9050927.

Full text

Abstract:

Many pathogenic bacteria, including Escherichia coli and Vibrio cholerae, can become viable but nonculturable (VBNC) following exposure to specific stress conditions. Corynebacterium diphtheriae, a known human pathogen causing diphtheria, has not previously been shown to enter the VBNC state. Here, we report that C. diphtheriae can become VBNC when exposed to low temperatures. Morphological differences in culturable and VBNC C. diphtheriae were examined using scanning electron microscopy. Culturable cells presented with a typical rod-shape, whereas VBNC cells showed a distorted shape with an e

APA, Harvard, Vancouver, ISO, and other styles

26

Prygiel, Marta, Ewa Mosiej, Maciej Polak, et al. "Challenges of Diphtheria Toxin Detection." Toxins 16, no. 6 (2024): 245. http://dx.doi.org/10.3390/toxins16060245.

Full text

Abstract:

Diphtheria toxin (DT) is the main virulence factor of Corynebacterium diphtheriae, C. ulcerans and C. pseudotuberculosis. Moreover, new Corynebacterium species with the potential to produce diphtheria toxin have also been described. Therefore, the detection of the toxin is the most important test in the microbiological diagnosis of diphtheria and other corynebacteria infections. Since the first demonstration in 1888 that DT is a major virulence factor of C. diphtheriae, responsible for the systemic manifestation of the disease, various methods for DT detection have been developed, but the diag

APA, Harvard, Vancouver, ISO, and other styles

27

MAHOMED, S., M. ARCHARY, P. MUTEVEDZI, et al. "An isolated outbreak of diphtheria in South Africa, 2015." Epidemiology and Infection 145, no. 10 (2017): 2100–2108. http://dx.doi.org/10.1017/s0950268817000851.

Full text

Abstract:

SUMMARYAn outbreak of respiratory diphtheria occurred in two health districts in the province of KwaZulu-Natal in South Africa in 2015. A multidisciplinary outbreak response team was involved in the investigation and management of the outbreak. Fifteen cases of diphtheria were identified, with ages ranging from 4 to 41 years. Of the 12 cases that were under the age of 18 years, 9 (75%) were not fully immunized for diphtheria. The case fatality was 27%. Ninety-three household contacts, 981 school or work contacts and 595 healthcare worker contacts were identified and given prophylaxis against C

APA, Harvard, Vancouver, ISO, and other styles

28

Sajid, Khandaker Md Tasnim, and Tarana Jahan. "Resurgence of Diphtheria: A Narrative Review." Journal of Monno Medical College 10, no. 2 (2025): 94–103. https://doi.org/10.3329/jmomc.v10i2.78122.

Full text

Abstract:

Changes in the epidemiology of diphtheria are occurring worldwide. Waning immunity to diphtheria was observed over time after childhood vaccination. After immunization in childhood, appropriate re-vaccinations are omitted for various reasons. Fear of adverse reactions in the course of diphtheria booster vaccination bears much of the responsibility. A large proportion of adults in many industrialized and developing countries are now susceptible to diphtheria. Inadequate boosting of previously vaccinated individuals may result in increased risk of acquiring the disease from a carrier, even if ad

APA, Harvard, Vancouver, ISO, and other styles

29

Hutauruk, Syahrial Marsinta, Fauziah Fardizza, and Sevi Aristya. "Tonsilitis difteri dengan sumbatan jalan napas atas." Oto Rhino Laryngologica Indonesiana 48, no. 1 (2018): 95. http://dx.doi.org/10.32637/orli.v48i1.260.

Full text

Abstract:

Latar belakang: Difteri adalah penyakit infeksi yang disebabkan oleh kuman bacillus grampositif Corynebacterium diphtheriae. Bakteri ini terutama menyebabkan infeksi pada saluran napasberupa tonsilofaringitis, laringitis, maupun keduanya secara bersamaan, ditandai dengan terbentuknyapseudomembran. Kematian pada anak dengan penyakit ini umumnya terjadi karena sumbatan jalannapas atas, ataupun efek sistemik toksin difteri. Tujuan: Melaporkan dan menganalisis kasus tonsilitisdifteri yang berakhir dengan kematian meskipun telah mendapat tatalaksana sumbatan jalan napas atas.Laporan kasus: Kasus an

APA, Harvard, Vancouver, ISO, and other styles

30

Simonova, Maria A., Vyacheslav G. Melnikov, Olga E. Lakhtina, et al. "Determination of Diphtheria Toxin in Bacterial Cultures by Enzyme Immunoassay." Diagnostics 12, no. 9 (2022): 2204. http://dx.doi.org/10.3390/diagnostics12092204.

Full text

Abstract:

Since diphtheria toxin (DT) is the main virulence factor of Corynebacterium diphtheriae and C. ulcerans, the detection of DT in corynebacterial cultures is of utmost importance in the laboratory diagnosis of diphtheria. The need to measure the level of DT production (LTP) arises when studying the virulence of a strain for the purpose of diphtheria agent monitoring. To determine the LTP of diphtheria agents, an immunoassay based on monoclonal antibodies (mAbs) has been developed. A pair of mAbs specific to the fragment B of DT was selected, which makes it possible to detect DT in a sandwich ELI

APA, Harvard, Vancouver, ISO, and other styles

31

Vernanda, Elisa Pingky, Julia Afianti, Diana Claudya Gustafiani, and Tukiman Tukiman. "Efektivitas Sosialisasi Outbreak Response Immunization (ORI) Terhadap Pelajar di Desa Laweyan Kecamatan Sumberasih Kabupaten Probolinggo." Jurnal Administrasi Pemerintahan Desa 5, no. 1 (2023): 11. http://dx.doi.org/10.47134/villages.v5i1.79.

Full text

Abstract:

Diphtheria is a highly contagious disease, and is caused by the gram-positive bacteria Corynebacterium diphtheriae toxin strain. This disease is characterized by inflammation at the site of infection, especially the mucous membranes of the pharynx, larynx, tonsils, nose and also the skin. The number of diphtheria cases in East Java as of March 2023 is 51 cases spread across 26 districts/cities with a total of 4 deaths. DPT immunization in Indonesia began in 1976 and was given 3 times, namely to babies aged 2, 3 and 4 months. Furthermore, DPT immunization was included in the School Children's I

APA, Harvard, Vancouver, ISO, and other styles

32

Musa, Sani, Salisu Usaini, Idris Ahmed, Chanakarn Kiataramkul, and Jessada Tariboon. "Dynamics of the Diphtheria Epidemic in Nigeria: Insights from the Kano State Outbreak Data." Mathematics 13, no. 7 (2025): 1189. https://doi.org/10.3390/math13071189.

Full text

Abstract:

Diphtheria is a severely infectious and deadly bacterial disease with Corynebacterium diphtheriae as the causative agent. Since the COVID-19 pandemic, contagious diseases such as diphtheria have re-emerged due to disruptions in routine childhood immunization programs worldwide. Nigeria is witnessing a significant increase in diphtheria outbreaks likely due to an inadequate health care system and insufficient public enlightenment campaign. This paper presents a mathematical epidemic diphtheria model in Nigeria, which includes a public enlightenment campaign to assess its positive impact on the

APA, Harvard, Vancouver, ISO, and other styles

33

Mustika, Diva Arum, Rani Nooraeni, and Indonesian Journal of Statistics and Its Applications IJSA. "KAJIAN EFEK SPASIAL KASUS DIFTERI DENGAN GEOGRAPHICALLY WEIGHTED NEGATIVE BINOMIAL REGRESSION (GWNBR)." Indonesian Journal of Statistics and Its Applications 3, no. 1 (2019): 91–104. http://dx.doi.org/10.29244/ijsa.v3i1.185.

Full text

Abstract:

Diphtheria is an infectious disease caused by the Corynebacterium diphtheriae bacteria. Indonesia is the country with the most cases of diphtheria in Southeast Asia and ranks third in the world. In 2016, cases of diphtheria increased by 65 percent and became Extraordinary Events (KLB) in Indonesia, even though during 2013 to 2015 the number of cases of diphtheria has decreased. The province that has the highest number of diphtheria cases in Indonesia in 2016 is East Java. Diphtheria is centered and spread in certain districts / cities in East Java Province so that there are indications of spat

APA, Harvard, Vancouver, ISO, and other styles

34

Fajriyah, Ishmatul. "The Relationship Between Knowledge of Mother and Family Support with Immunization Status Td in Sub PIN Difteri." Jurnal Berkala Epidemiologi 2, no. 3 (2014): 404. http://dx.doi.org/10.20473/jbe.v2i3.2014.404-415.

Full text

Abstract:

ABSTRACTThe number cases of diphtheria in East Java have increased more years. Surabaya is one of cities that implemented the Sub Pekan Imunisasi Nasional (PIN) Diphtheria. Sub PIN Diphtheria is a program that aims to break the chain of diphtheria transmission. Children aged > 7–15 years are one of the program’s targets Sub PIN Diphtheria. Sub PIN coverage for groups of children aged > 7–15 years in Kalijudan Public Health Center (PHC) only 79.15%, while the predetermined minimum target is 95%. This study was conducted to determine the relationship between knowledge and support from fami

APA, Harvard, Vancouver, ISO, and other styles

35

Fajriyah, Ishmatul. "The Relationship Between Knowledge of Mother and Family Support with Immunization Status Td in Sub PIN Difteri." Jurnal Berkala Epidemiologi 2, no. 3 (2014): 404. http://dx.doi.org/10.20473/jbe.v2i32014.404-415.

Full text

Abstract:

ABSTRACTThe number cases of diphtheria in East Java have increased more years. Surabaya is one of cities that implemented the Sub Pekan Imunisasi Nasional (PIN) Diphtheria. Sub PIN Diphtheria is a program that aims to break the chain of diphtheria transmission. Children aged > 7–15 years are one of the program’s targets Sub PIN Diphtheria. Sub PIN coverage for groups of children aged > 7–15 years in Kalijudan Public Health Center (PHC) only 79.15%, while the predetermined minimum target is 95%. This study was conducted to determine the relationship between knowledge and support from fami

APA, Harvard, Vancouver, ISO, and other styles

36

Sutton-Fitzpatrick, Una, Conor Grant, Dimitar Nashev, and Catherine Fleming. "Corynebacterium diphtheriae bloodstream infection: the role of antitoxin." BMJ Case Reports 12, no. 11 (2019): e231914. http://dx.doi.org/10.1136/bcr-2019-231914.

Full text

Abstract:

A 65-year-old male patient presented with fever, fast atrial fibrillation and frank haematuria on return to Ireland from travel in East Africa. He had a systolic murmur leading to a clinical suspicion of endocarditis. He had no specific clinical features of diphtheria. Blood cultures were taken and empiric therapy commenced with benzylpenicillin, vancomycin and gentamicin. Corynebacterium diphtheriae was detected on blood culture. The isolate was submitted to a reference laboratory for evaluation of toxigenicity. While initially there was concern regarding the possibility of myocarditis, a cli

APA, Harvard, Vancouver, ISO, and other styles

37

He, Qing, Yejian Wu, Shuiping Hou, Lei Luo, and Zhoubin Zhang. "Seroprevalence of Diphtheria and Tetanus Immunoglobulin G among the General Health Population in Guangzhou, China." Vaccines 12, no. 4 (2024): 381. http://dx.doi.org/10.3390/vaccines12040381.

Full text

Abstract:

A seroepidemiological study was conducted in 2018 to assess diphtheria and tetanus antibodies in Guangzhou, China. Diphtheria and tetanus antibody concentrations were measured with an enzyme-linked immunosorbent assay. A total of 715 subjects were enrolled in the study. The overall diphtheria and tetanus toxoid IgG-specific antibody levels were 0.126 IU/mL (95% CI: 0.115, 0.137) and 0.210 IU/mL (95% CI: 0.185, 0.240), respectively; the overall positivity rate was 61.82% (95% CI: 58.14, 65.39) and 71.61% (95% CI: 68.3, 74.92), respectively. The diphtheria and tetanus antibody concentration was

APA, Harvard, Vancouver, ISO, and other styles

38

Egbune, Ngozika J., Eloho B. Akponana, Eirene O. Arierhie, and Akindele M. Okedoye. "Mathematical Analysis of Spread and Control of Diphtheria with Emphasis on Diphtheria Antitoxin Efficiency." European Journal of Theoretical and Applied Sciences 2, no. 3 (2024): 152–72. http://dx.doi.org/10.59324/ejtas.2024.2(3).14.

Full text

Abstract:

Diphtheria, a bacterial infection caused by Corynebacterium diphtheriae, remains a significant public health concern worldwide. In this study, we employ mathematical modeling to analyze the spread and control of diphtheria, focusing on the efficacy of Diphtheria Antitoxin in mitigating the disease's impact. Through the development of compartmental models, system of differential equations governing the dynamics was formulated. Due to the complexity and non-linearity of the dynamics, a numerical solutions that utilizes Runge-Kutta Fehlberg order 4 and 5 method. The dynamics of diphtheria transmi

APA, Harvard, Vancouver, ISO, and other styles

39

M Akindele, Okedoye, and Eloho B Akponana. "Mathematical Analysis of Spread and Control of Diphtheria with Emphasis on Diphtheria Antitoxin Efficiency." International Journal of Advanced Multidisciplinary Research and Studies 5, no. 1 (2025): 972–90. https://doi.org/10.62225/2583049x.2025.5.1.3751.

Full text

Abstract:

Diphtheria, a bacterial infection caused by Corynebacterium diphtheriae, remains a significant public health concern worldwide. In this study, we employ mathematical modeling to analyze the spread and control of diphtheria, focusing on the efficacy of Diphtheria Antitoxin in mitigating the disease's impact. Through the development of compartmental models, system of differential equations governing the dynamics was formulated. Due to the complexity and non-linearity of the dynamics, a numerical solution that utilizes Runge-Kutta Fehlberg order 4 and 5 method. The dynamics of diphtheria transmis

APA, Harvard, Vancouver, ISO, and other styles

40

Ngozika, J. Egbune, B. Akponana Eloho, O. Arierhie Eirene, and M. Okedoye Akindele. "Mathematical Analysis of Spread and Control of Diphtheria with Emphasis on Diphtheria Antitoxin Efficiency." European Journal of Theoretical and Applied Sciences 2, no. 3 (2024): 152–72. https://doi.org/10.59324/ejtas.2024.2(3).14.

Full text

Abstract:

Diphtheria, a bacterial infection caused by Corynebacterium diphtheriae, remains a significant public health concern worldwide. In this study, we employ mathematical modeling to analyze the spread and control of diphtheria, focusing on the efficacy of Diphtheria Antitoxin in mitigating the disease's impact. Through the development of compartmental models, system of differential equations governing the dynamics was formulated. Due to the complexity and non-linearity of the dynamics, a numerical solutions that utilizes Runge-Kutta Fehlberg order 4 and 5 method. The dynamics of diphtheria transmi

APA, Harvard, Vancouver, ISO, and other styles

41

Borisova, O. Yu, N. T. Gadua, A. S. Pimenova, et al. "Comparative tests of quality of bacteriological investigation with Corynebacterium diphtheriae isolation." Russian Clinical Laboratory Diagnostics 66, no. 8 (2021): 509–12. http://dx.doi.org/10.51620/0869-2084-2021-66-8-509-512.

Full text

Abstract:

The results of comparative experimental studies of identification of nontoxigenic C. diphtheriae strain by three different commercial laboratories are presented. A typical nontoxigenic strain of C. diphtheriae biovar mitis was used. For the studies, three lines of ten-fold dilutions of bacterial culture were prepared, followed by control planting on the medium and counting CFU/ml. In the experiment, tampons were pooled with a 24-hour bacterial culture of a nontoxigenic C. diphtheriae strain. Tampons were provided from three different laboratories - ∑-Transwab® with Ames liquid medium (from the

APA, Harvard, Vancouver, ISO, and other styles

42

Nastiti, Hilari Rio Rosa, and Rachmad Bayu Kuncara. "Desain Primer untuk Deteksi Gen Diphtheria Toxin Repressor (dtxR) sebagai Biomarker Bakteri Corynebacterium diphtheriae Menggunakan In Silico PCR." Jaringan Laboratorium Medis 5, no. 2 (2023): 136–43. http://dx.doi.org/10.31983/jlm.v5i2.10588.

Full text

Abstract:

Corynebacterium diphtheriae is the bacteria that causes diphtheria. The virulence factor of C. diphtheriae comes from the bacteria's ability to produce bacterial toxins. Toxin production is regulated by a set of genes called tox/dtx genes and is regulated by the dtxR gene. The aim of this study was to design primers used to evaluate the dtxR gene using bacterial DNA sequences. This research is experimental research with a literature study approach using the In silico Polymerase Chain Reaction (PCR), NCBI (National Center for Biotechnology Information), Primer3Plus, and Oligo Calculator applica

APA, Harvard, Vancouver, ISO, and other styles

43

Anoushka, Sahai, Shriwastav Pooja, Narkhede Kartik, Gaikwad Ashwinikumar, and Marfatia Hetal. "Diphtheria Revisited: An Interesting Case Report from India." International Journal of Pharmaceutical and Clinical Research 15, no. 8 (2023): 236–38. https://doi.org/10.5281/zenodo.11457942.

Full text

Abstract:

<strong>Background:</strong> Diphtheria, caused by Corynebacterium diphtheriae, remains a significant concern in developing nations like India, where vaccination efforts encounter obstacles. This study presents a critical case of diphtheria-induced airway obstruction in an 8-year-old Indian girl, emphasizing the importance of early detection and management in resource-constrained contexts. <strong>Case Presentation:</strong> At a Western Indian tertiary care hospital, an 8-year-old girl exhibited sudden breathlessness, mouth breathing, and midline neck swelling, along with four

APA, Harvard, Vancouver, ISO, and other styles

44

Annamalai, Medeshni. "Diphtheria and the respiratory system: Lessons from 2015 Outbreak." South African Respiratory Journal 22, no. 2 (2016): 38. http://dx.doi.org/10.7196/sarj.2016.v22i2.75.

Full text

Abstract:

<p> </p><p align="left">South Africa experienced a diphtheria outbreak in KwaZulu-Natal Province between March and August 2015. Diphtheria is a contagious and potentially life-threatening bacterial disease caused by the toxigenic strains of <em><span style="font-family: MinionPro-It; font-size: xx-small;">Corynebacterium diphtheriae.</span></em> </p>

APA, Harvard, Vancouver, ISO, and other styles

45

K. R., Sachin, Ramesh H., Sachin K. G., and Siddharth E. S. "The outcome of resurgence of diphtheria in older children in a tertiary care hospital." International Journal of Contemporary Pediatrics 6, no. 2 (2019): 607. http://dx.doi.org/10.18203/2349-3291.ijcp20190696.

Full text

Abstract:

Background: Diphtheria is a fatal bacterial infection which affects the mucous membranes of oropharyngeal and nasal cavity, caused by aerobic gram-positive bacteria Corynebacterium diphtheriae. With the advent of universal immunization against diphtheria the incidence of this infectious disease has declined dramatically with few developed nations having eradicated the disease. No large outbreaks have been reported in India in recent times.Methods: In present study, authors reviewed an outbreak of diphtheria in Davangere between the months of June 2017 and July 2018. Case records of children su

APA, Harvard, Vancouver, ISO, and other styles

46

Wijayanti, Siwi Pramatama Mars, and Alfianti Nur Fadillah. "EPIDEMIOLOGY OF DIPHTERIA IN PURWAKARTA REGENCY INDONESIA." Epidemiology and Society Health Review (ESHR) 1, no. 1 (2019): 9. http://dx.doi.org/10.26555/eshr.v1i1.935.

Full text

Abstract:

Background: Diphtheria is considered as a neglected disease since it was successfully eliminated in many countries. However, there were several sporadic re-emergence cases of Diphtheria and the peak was outbreak in Indonesia in 2017. This research was a descriptive study aimed to explore epidemiology of diphtheria by person, time and place in one of diphtheria endemic area.Methods: This was a descriptive study with cross sectional design in Purwakarta Regency, West Java, Indonesia in 2018. Several data were collected in this study such as diphtheria cases by age, time of occurrence, gender, pl

APA, Harvard, Vancouver, ISO, and other styles

47

Musa, Abubakar, Usman Abba, Esther Adesina Oluwatobi, et al. "Predictors of knowledge, attitude and perception of diphtheria infection and vaccination among medical students in Abubakar Tafawa Balewa University, Bauchi North-Eastern Nigeria." International Journal Of Community Medicine And Public Health 12, no. 2 (2025): 709–18. https://doi.org/10.18203/2394-6040.ijcmph20250301.

Full text

Abstract:

Background: Diphtheria is a highly contagious infection caused by Corynebacterium diphtheriae and other strains that affect respiratory system. Commonly transmitted through inhalation of airborne droplets or handling contaminated items. The main stay of prevention is vaccination. Hence, this study assessed the level of knowledge, attitude and perception of diphtheria infection and vaccination among medical students in Abubakar Tafawa Balewa University Bauchi State, Northeastern Nigeria. Methods: A cross-sectional descriptive study was carried out among 210 Medical students in Bauchi State from

APA, Harvard, Vancouver, ISO, and other styles

48

Ningsih, Retno. "Epidemiological Investigation of Diphtheria Extraordinary Events (KLB) In Gili Ketapang Village, Probolinggo Regency In 2022." Asian Journal of Healthy and Science 2, no. 12 (2023): 912–26. http://dx.doi.org/10.58631/ajhs.v2i12.23.

Full text

Abstract:

Diphtheria infection is caused by a toxigenic strain of Corynebacterium diphtheriae with humans as the only reservoir. Diphtheria attacks children under 10 years old and is highly contagious, especially in susceptible populations. Diphtheria can cause an outbreak although it can be prevented by immunization. In 2022, 3 cases of diphtheria were reported in Gili Ketapang Village, Probolinggo Regency. Objective: to describe the epidemiology of the outbreak and identify the risk factors for countermeasures. Methods: This research is a descriptive study with an outbreak investigation report design.

APA, Harvard, Vancouver, ISO, and other styles

49

Dr., Gouthami. E., Shailaja Rani.M Dr., Shashikala Reddy.P Dr., and Sudha Rani Dr. "A study on detection and characterization of corynebacterium diphtheriae isolated from throat swabs by using manual methods and molecular techniques at a tertiary care hospital." International Journal of Scientific Development and Research 9, no. 5 (2024): 98–103. https://doi.org/10.5281/zenodo.11256354.

Full text

Abstract:

Corynebacterium diphtheriae is an exotoxin producing Gram positive bacillus which causes an upper respiratory tract infection known as Diphtheria. It is a vaccine preventable disease. Even with the successful implementation of universal immunization, the pathogen is reemerging in India due to waning of immunity. The diagnosis of Diphtheria is mainly based on clinical presentation, but the microbiological identification of the pathogen and detection of toxin production is as much as important to prevent the complications of Diphtheria. The current study is conducted at Sir Ronald Ross Institute

APA, Harvard, Vancouver, ISO, and other styles

50

Kharseeva, G. G., S. Yu Tyukavkina, and A. Yu Mironov. "Diphtheria: characteristics of the pathogen and laboratory diagnostics (lecture)." Russian Clinical Laboratory Diagnostics 65, no. 11 (2020): 699–706. http://dx.doi.org/10.18821/0869-2084-2020-65-11-699-706.

Full text

Abstract:

The problem of diphtheria infection remains relevant, since the circulation of toxigenic strains of Corynebacterium diphtheriae persists in the body of bacterial carriers, despite ongoing vaccination. The lecture presents modern ideas about the properties of the pathogen, its pathogenicity factors (toxin, pili, surface proteins (67-72P (or DIP0733), DIP1281, etc.) and their role in the pathogenesis of the disease.. Information about the clinical and epidemiological characteristics and modern methods of laboratory diagnostics of diphtheria is presented. The algorithm of bacteriological research

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!