Academic literature on the topic 'Direct cardiac reprogramming'

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Journal articles on the topic "Direct cardiac reprogramming"

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Qian, Li, and Deepak Srivastava. "Direct Cardiac Reprogramming." Circulation Research 113, no. 7 (2013): 915–21. http://dx.doi.org/10.1161/circresaha.112.300625.

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Sadahiro, Taketaro, Shinya Yamanaka, and Masaki Ieda. "Direct Cardiac Reprogramming." Circulation Research 116, no. 8 (2015): 1378–91. http://dx.doi.org/10.1161/circresaha.116.305374.

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Bruneau, Benoit G. "Direct Reprogramming for Cardiac Regeneration." Circulation Research 110, no. 11 (2012): 1392–94. http://dx.doi.org/10.1161/circresaha.112.270637.

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Kim, Junyeop, Yujung Chang, Yerim Hwang, Sumin Kim, Yu-Kyoung Oh, and Jongpil Kim. "Graphene Nanosheets Mediate Efficient Direct Reprogramming into Induced Cardiomyocytes." Journal of Biomedical Nanotechnology 18, no. 9 (2022): 2171–82. http://dx.doi.org/10.1166/jbn.2022.3416.

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In vivo cardiac reprogramming is a potential therapeutic strategy to replace cardiomyocytes in patients with myocardial infarction. However, low conversion efficiency is a limitation of In vivo cardiac reprogramming for heart failure. In this study, we showed that graphene nanosheets mediated efficient direct reprogramming into induced cardiomyocytes In vivo. We observed that the administration of graphene nanosheets led to the accumulation of H3K4me3, which resulted in direct cardiac reprogramming. Importantly, the administration of graphene nanosheets combined with cardiac reprogramming fact
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Chen, Olivia, and Li Qian. "Direct Cardiac Reprogramming: Advances in Cardiac Regeneration." BioMed Research International 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/580406.

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Heart disease is one of the lead causes of death worldwide. Many forms of heart disease, including myocardial infarction and pressure-loading cardiomyopathies, result in irreversible cardiomyocyte death. Activated fibroblasts respond to cardiac injury by forming scar tissue, but ultimately this response fails to restore cardiac function. Unfortunately, the human heart has little regenerative ability and long-term outcomes following acute coronary events often include chronic and end-stage heart failure. Building upon years of research aimed at restoring functional cardiomyocytes, recent advanc
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Zhang, Zhentao, Jesse Villalpando, Wenhui Zhang, and Young-Jae Nam. "Chamber-Specific Protein Expression during Direct Cardiac Reprogramming." Cells 10, no. 6 (2021): 1513. http://dx.doi.org/10.3390/cells10061513.

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Forced expression of core cardiogenic transcription factors can directly reprogram fibroblasts to induced cardiomyocyte-like cells (iCMs) in vitro and in vivo. This cardiac reprogramming approach provides a proof of concept for induced heart regeneration by converting a fibroblast fate to a cardiomyocyte fate. However, it remains elusive whether chamber-specific cardiomyocytes can be generated by cardiac reprogramming. Therefore, we assessed the ability of the cardiac reprogramming approach for chamber specification in vitro and in vivo. We found that in vivo cardiac reprogramming post-myocard
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Ambroise, Rachelle, Paige Takasugi, Jiandong Liu, and Li Qian. "Direct Cardiac Reprogramming in the Age of Computational Biology." Journal of Cardiovascular Development and Disease 11, no. 9 (2024): 273. http://dx.doi.org/10.3390/jcdd11090273.

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Heart disease continues to be one of the most fatal conditions worldwide. This is in part due to the maladaptive remodeling process by which ischemic cardiac tissue is replaced with a fibrotic scar. Direct cardiac reprogramming presents a unique solution for restoring injured cardiac tissue through the direct conversion of fibroblasts into induced cardiomyocytes, bypassing the transition through a pluripotent state. Since its inception in 2010, direct cardiac reprogramming using the transcription factors Gata4, Mef2c, and Tbx5 has revolutionized the field of cardiac regenerative medicine. Just
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Tani, Hidenori, Taketaro Sadahiro, and Masaki Ieda. "Direct Cardiac Reprogramming: A Novel Approach for Heart Regeneration." International Journal of Molecular Sciences 19, no. 9 (2018): 2629. http://dx.doi.org/10.3390/ijms19092629.

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Cardiac diseases are among the most common causes of death globally. Cardiac muscle has limited proliferative capacity, and regenerative therapies are highly in demand as a new treatment strategy. Although pluripotent reprogramming has been developed, it has obstacles, such as a potential risk of tumor formation, poor survival of the transplanted cells, and high cost. We previously reported that fibroblasts can be directly reprogrammed to cardiomyocytes by overexpressing a combination of three cardiac-specific transcription factors (Gata4, Mef2c, Tbx5 (together, GMT)). We and other groups have
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Tang, Yawen, Sajesan Aryal, Xiaoxiao Geng, et al. "TBX20 Improves Contractility and Mitochondrial Function During Direct Human Cardiac Reprogramming." Circulation 146, no. 20 (2022): 1518–36. http://dx.doi.org/10.1161/circulationaha.122.059713.

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Background: Direct cardiac reprogramming of fibroblasts into cardiomyocytes has emerged as a promising strategy to remuscularize injured myocardium. However, it is insufficient to generate functional induced cardiomyocytes from human fibroblasts using conventional reprogramming cocktails, and the underlying molecular mechanisms are not well studied. Methods: To discover potential missing factors for human direct reprogramming, we performed transcriptomic comparison between human induced cardiomyocytes and functional cardiomyocytes. Results: We identified TBX20 (T-box transcription factor 20) a
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Perveen, Sadia, Roberto Vanni, Marco Lo Iacono, Raffaella Rastaldo, and Claudia Giachino. "Direct Reprogramming of Resident Non-Myocyte Cells and Its Potential for In Vivo Cardiac Regeneration." Cells 12, no. 8 (2023): 1166. http://dx.doi.org/10.3390/cells12081166.

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Cardiac diseases are the foremost cause of morbidity and mortality worldwide. The heart has limited regenerative potential; therefore, lost cardiac tissue cannot be replenished after cardiac injury. Conventional therapies are unable to restore functional cardiac tissue. In recent decades, much attention has been paid to regenerative medicine to overcome this issue. Direct reprogramming is a promising therapeutic approach in regenerative cardiac medicine that has the potential to provide in situ cardiac regeneration. It consists of direct cell fate conversion of one cell type into another, avoi
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Dissertations / Theses on the topic "Direct cardiac reprogramming"

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Bachamanda, Somesh Dipthi [Verfasser]. "Induced cardiomyocyte precursor cells obtained by direct reprogramming of cardiac fibroblasts / Dipthi Bachamanda Somesh." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2020. http://d-nb.info/1223925676/34.

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Elkhoury, Kamil. "Nanofunctionalization and biofabrication of natural hydrogels for tissue engineering applications." Electronic Thesis or Diss., Université de Lorraine, 2021. http://www.theses.fr/2021LORR0020.

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L’objectif principal de cette thèse est de développer un nouveau matériau naturel à base de ‎gélatine modifiée par méthacrylation (GelMA) nanofonctionnalisé par l’incorporation de ‎nanoliposomes ou de nanoparticules hybrides molles de type exosome-liposome. Ces ‎matrices hydrogel sont caractérisées d’un point de vue physicochimique et biologique afin ‎d'évaluer leur potentiel en ingénierie tissulaire. Le GelMA est préparé par modification ‎chimique de la gélatine, lorsque des groupements méthacrylate sont fixés sur des groupes ‎latéraux contenant des fonctions amine. Dans une première partie d
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Book chapters on the topic "Direct cardiac reprogramming"

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Haginiwa, Sho, and Masaki Ieda. "Direct Cardiac Reprogramming." In Cardiac and Vascular Biology. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-56106-6_6.

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Liu, Dingqian, Khawaja Husnain Haider, and Changfa Guo. "Bioengineering Technique Progress of Direct Cardiac Reprogramming." In Handbook of Stem Cell Therapy. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-2655-6_27.

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Jayawardena, Tilanthi, Maria Mirotsou, and Victor J. Dzau. "Direct Reprogramming of Cardiac Fibroblasts to Cardiomyocytes Using MicroRNAs." In Methods in Molecular Biology. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0512-6_18.

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Paoletti, Camilla, Carla Divieto, and Valeria Chiono. "Direct Reprogramming of Adult Human Cardiac Fibroblasts into Induced Cardiomyocytes Using miRcombo." In Methods in Molecular Biology. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2707-5_3.

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Ma, Hong, Li Wang, Jiandong Liu, and Li Qian. "Direct Cardiac Reprogramming as a Novel Therapeutic Strategy for Treatment of Myocardial Infarction." In Methods in Molecular Biology. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6588-5_5.

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Paoletti, Camilla, Carla Divieto, and Valeria Chiono. "Correction to: Direct Reprogramming of Adult Human Cardiac Fibroblasts into Induced Cardiomyocytes Using miRcombo." In Methods in Molecular Biology. Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-2707-5_27.

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Jain, Pooja, Nazia Hassan, Uzma Farooq, and Zeenat Iqbal. "Nanotechnology-Based Direct Cardiac Reprogramming for Cardiac Regeneration." In Nanomedicinal Approaches Towards Cardiovascular Disease. BENTHAM SCIENCE PUBLISHERS, 2021. http://dx.doi.org/10.2174/9789814998215121010015.

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Haridhasapavalan, Krishna Kumar, Atreyee Borthakur, and Rajkumar P. Thummer. "Direct Cardiac Reprogramming: Current Status and Future Prospects." In Advances in Experimental Medicine and Biology. Springer International Publishing, 2023. http://dx.doi.org/10.1007/5584_2022_760.

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Conference papers on the topic "Direct cardiac reprogramming"

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Klose, K., M. Gossen, and C. Stamm. "Direct Genetic and/or Pharmacologic Reprogramming for Creation of Cardiomyocytes: Is It Real?" In 48th Annual Meeting German Society for Thoracic, Cardiac, and Vascular Surgery. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1678823.

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