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Journal articles on the topic 'Directly Compressible Co-Processed Excipients'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

S B, Sandhan, Wagh M P, and Inamdar Nazma. "Development of Novel Directly Compressible Isomalt-based Co-processed Excipient." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 02 (2022): 620–26. http://dx.doi.org/10.25258/ijddt.13.2.24.

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Objective: The study aims to improve the tableting qualities by coprocessing isomalt with PEG 4000 and crospovidone. Methodology: The melt granulation method was adopted for coprocessing isomalt with PEG 4000 and crospovidone. The proportion of constituents was optimized using full factorial design. Particle size distribution, true density, moisture content, flowability, flow rate, SEM analysis, dilution potential, and tablet ability were all examined for optimized co-processed isomalt-based excipient and compared with isomalt. Result and Discussion: Co-processed isomalt-based excipients had 4

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Aleksić, Ivana, Teodora Glišić, Slobodanka Ćirin-Varađan, Mihal Djuris, Jelena Djuris, and Jelena Parojčić. "Evaluation of the Potential of Novel Co-Processed Excipients to Enable Direct Compression and Modified Release of Ibuprofen." Pharmaceutics 16, no. 11 (2024): 1473. http://dx.doi.org/10.3390/pharmaceutics16111473.

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Background/Objectives: Improving the production rates of modern tablet presses places ever greater demands on the performance of excipients. Although co-processing has emerged as a promising solution, there is still a lack of directly compressible excipients for modified-release formulations. The aim of the present study was to address this issue by investigating the potential of novel co-processed excipients for the manufacture of modified-release tablets containing ibuprofen. Methods: The excipients were prepared by melt granulation of lactose monohydrate with glyceryl palmitostearate as a b

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Okunlola, A., and T. A. Gbadamosi. "Compaction and Tableting Behavior of a Novel Co-Processed Excipient in the Formulation of Metoprolol Succinate Tablets." Nigerian Journal of Pharmaceutical Research 16, no. 2 (2021): 127–42. http://dx.doi.org/10.4314/njpr.v16i2.4.

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Background: Pregelatinized starches exhibit good swelling and flow properties, imparting fast disintegration time but low mechanical strength in tablets. On the other hand, acacia gum acts as a binder in tablets by imparting high mechanical strength but prolonged disintegration time. Development of a co-processed excipient involving combination of the two excipients at sub-particle level will improve the functionality of the final product.Objective: To develop a direct compressible co-processed excipient with pregelatinized cocoyam starch and acacia gum and to evaluate its compaction behavior

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Patel, Jalpa, and Dhaval Mori. "Application of 32 Full Factorial Design and Desirability Function for Optimizing The Manufacturing Process for Directly Compressible Multi-Functional Co-Processed Excipient." Current Drug Delivery 17, no. 6 (2020): 523–39. http://dx.doi.org/10.2174/1567201817666200508094743.

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Background: Developing a new excipient and obtaining its market approval is an expensive, time-consuming and complex process. Compared to that, the co-processing of already approved excipients has emerged as a more attractive option for bringing better characteristic excipients to the market. The application of the Design of Experiments (DoE) approach for developing co-processed excipient can make the entire process cost-effective and rapid. Objective: The aim of the present investigation was to demonstrate the applicability of the DoE approach, especially 32 full factorial design, to develop

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Akonlula, A. "Preliminary Characterization of Co-processed Excipients of Okra (Abelmoschus esculentus) Mucilage and Pregelatinized Potato Starch." Nigerian Journal of Pharmaceutical Research 16, no. 2 (2021): 119–29. http://dx.doi.org/10.4314/njpr.v16i2.14s.

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Background: Okra mucilage is highly viscous with good binding properties in tablets. Pregelatinized starches have significantly improved flow properties but produce tablets of poor mechanical strength.Objective: Preliminary evaluation of co-processed excipients of Okra mucilage and pregelatinized potato starch as directly-compressible excipients.Methods: Polymers were characterized for morphology (SEM), crystallinity (FT-IR) and flow properties. Coprocessed excipients were developed with Okra mucilage and pregelatinized potato starch at different ratios of starch: mucilage (95:5, 90:10, 85:15,

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Iancu, Valeriu, Florentina Roncea, Radu George Cazacincu, and Dumitru Lupuleasa. "Preparation and evaluation of diclofenac sodium orally disintegrating tablets." Ovidius University Annals of Chemistry 27, no. 1 (2016): 58–61. http://dx.doi.org/10.1515/auoc-2016-0004.

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Abstract Orally disintegrating tablets (ODTs) are dosage forms which disintegrate in mouth within seconds without need of water. This type of quality in dosage form can be attained by addition of different varieties of excipients. Pharmaburst™ 500 is a co-processed excipient system which allows rapid disintegration and low adhesion to punches. The aim of the present study was to develop and evaluate 25 mg diclofenac sodium ODTs (orodispersible tablets) batches by direct compression method at different compression forces 10 kN (F1) and 20 kN (F2) and directly compressible excipients used in dif

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Djuris, Jelena, Slobodanka Cirin-Varadjan, Ivana Aleksic, Mihal Djuris, Sandra Cvijic, and Svetlana Ibric. "Application of Machine-Learning Algorithms for Better Understanding of Tableting Properties of Lactose Co-Processed with Lipid Excipients." Pharmaceutics 13, no. 5 (2021): 663. http://dx.doi.org/10.3390/pharmaceutics13050663.

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Co-processing (CP) provides superior properties to excipients and has become a reliable option to facilitated formulation and manufacturing of variety of solid dosage forms. Development of directly compressible formulations with high doses of poorly flowing/compressible active pharmaceutical ingredients, such as paracetamol, remains a great challenge for the pharmaceutical industry due to the lack of understanding of the interplay between the formulation properties, process of compaction, and stages of tablets’ detachment and ejection. The aim of this study was to analyze the influence of the

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Kushare, Sachin Shivaji, and S. G. Gattani. "Design and Development of a Microwave Generated Lactose Monohydrate - Microcrystalline Cellulose Based Multifunctional Excipient Composites for Tablet Formulation using Box–Behnken Design." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 1–17. http://dx.doi.org/10.22270/jddt.v9i4.3123.

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The concept of co-processing as a particle engineering technique continues to be used as a tool to enhance the functionality of several existing excipients. This important research was designed to improve the functionality of lactose monohydrate as excipient for direct compression by co-processing with microcrystalline cellulose. Microwave induced diffusion technique was first utilized for manufacturing Co processed lactose monohydrate (LM) - microcrystalline cellulose (MC) composites. The objective of the research was to obtain synergistic effects, incorporating better tablet adherence and ha

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Serrano-Mora, Luis Eduardo, María L. Zambrano-Zaragoza, Néstor Mendoza-Muñoz, Gerardo Leyva-Gómez, Zaida Urbán-Morlán, and David Quintanar-Guerrero. "Preparation of Co-Processed Excipients for Controlled-Release of Drugs Assembled with Solid Lipid Nanoparticles and Direct Compression Materials." Molecules 26, no. 7 (2021): 2093. http://dx.doi.org/10.3390/molecules26072093.

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The purpose of the study was to develop a novel, directly compressible, co-processed excipient capable of providing a controlled-release drug system for the pharmaceutical industry. A co-processed powder was formed by adsorption of solid lipid nanoparticles (SLN) as a controlled-release film onto a functional excipient, in this case, dicalcium phosphate dihydrate (DPD), for direct compression (Di-Tab®). The co-processed excipient has advantages: easy to implement; solvent-free; industrial scaling-up; good rheological and compressibility properties; and the capability to form an inert platform.

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Drašković, Milica, Jelena Djuriš, Svetlana Ibrić, and Jelena Parojčić. "Functionality and performance evaluation of directly compressible co-processed excipients based on dynamic compaction analysis and percolation theory." Powder Technology 326 (February 2018): 292–301. http://dx.doi.org/10.1016/j.powtec.2017.12.021.

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Sudha, R. K. V. Naga, G. Padmini, and T. E. G. K. Murthy. "Development of Novel Co-Processed Excipients for the Design and Evaluation of Directly Compressible Tablets of Rizatriptan Benzoate." Research Journal of Pharmaceutical Dosage Forms and Technology 7, no. 1 (2015): 07. http://dx.doi.org/10.5958/0975-4377.2015.00002.6.

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., Chetan Borkhataria, Ritesh Gurjar ., Jayant Chavda ., Ravi Manek ., Kaplesh Patel ., and Dhavalkumar Patel . "Development of Multifunctional Directly Compressible Co-processed Orodispersible Excipient Using Spray Drying Technique." Journal of Current Pharma Research 9, no. 3 (2019): 3002–19. http://dx.doi.org/10.33786/jcpr.2019.v09i03.019.

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Dureja, Harish, Nidhi Garg, Parijat Pandey, and Deepak Kaushik. "Development of novel multifunction directly compressible co-processed excipient by melt granulation technique." International Journal of Pharmaceutical Investigation 5, no. 4 (2015): 266. http://dx.doi.org/10.4103/2230-973x.167692.

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Yerima, Yohanah Dauda, Adamu Babah Isah, Avosuahi Rukayat Oyi, Aliyu Muhammad Musa, and Yonni Eshovo Apeji. "Direct Compression Properties of Co-Processed Excipient Containing Cow Bone Powder, Khaya Gum and Maize Starch." Malaysian Journal of Pharmaceutical Sciences 21, no. 1 (2023): 107–22. http://dx.doi.org/10.21315/mjps2023.21.1.7.

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The aim of this study was to evaluate the direct compression properties of a novel coprocessed excipient (CPE) generated by processing cow bone powder (CBP), maize starch (MS) and Khaya gum (KG) together to form a single composite excipient. Design of experiments (DoE) was employed to optimise the formulation of CPE. CPE was prepared by wet granulation using the optimised formulation of CBP (40%), MS (40%) and KG (20%) as recommended by DoE. Assessment of the organoleptic properties of CPE revealed an odourless, tasteless and coarse texture with a neutral pH of 7.3. CPE was found to be partly

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Chauhan, Sohil I., Sandeep V. Nathwani, Moinuddin M. Soniwala, and Jayant R. Chavda. "Development and Characterization of Multifunctional Directly Compressible Co-processed Excipient by Spray Drying Method." AAPS PharmSciTech 18, no. 4 (2016): 1293–301. http://dx.doi.org/10.1208/s12249-016-0598-8.

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Patel, Hetal, Aakash Ghayal, Ashish Mishra, and Shailesh Shah. "Formulation development of directly compressible co-processed excipient for sustained release of tramadol hydrochloride." Journal of Pharmaceutical Investigation 45, no. 1 (2014): 51–63. http://dx.doi.org/10.1007/s40005-014-0144-1.

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Trisopon, Karnkamol, Nisit Kittipongpatana, Pimjai Doungsaard, Neungreuthai Chomchoei, and Ornanong Suwannapakul Kittipongpatana. "A novel directly compressible co-processed excipient, based-on rice starch for extended-release of tablets." European Journal of Pharmaceutics and Biopharmaceutics 208 (March 2025): 114623. https://doi.org/10.1016/j.ejpb.2024.114623.

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Somnache, Sandesh Narayan, K. Vasantakumar Pai, Ajeet Madhukar Godbole, Pankaj Sadashiv Gajare, and Arti Shashikant Pednekar. "Development of M3 as Improved Functionality Composite Excipient for Direct Compression." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 15, no. 5 (2022): 6111–20. http://dx.doi.org/10.37285/ijpsn.2022.15.5.2.

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Introduction: Direct compression is the most preferred method of formulations of a compressed solid dosage form, but the poor compressibility of most of the active pharmaceutical ingredients limits the use of the direct compression technique.  Methodology: The present research study involves the development of M3 with improved functionality composite excipient used for direct compression. The aqueous dispersion of Maltose and Mannitol was co-processed with Maize Starch by using the co-drying technique. The dried composite was assessed for excipient functionalities such as Flowability, Co

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Akin-ajani, Olufunke D., Tolulope O. Ajala, Uchenna M. Okoli, and Ozioma Okonta. "Development of directly compressible excipients from phoenix dactylifera (date) mucilage and microcrystalline cellulose using co-processing techniques." ACTA Pharmaceutica Sciencia 56, no. 3 (2018): 7. http://dx.doi.org/10.23893/1307-2080.aps.05615.

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Kumar Vishwakarma Jai Narayan Mishra, Dhaneshwar, Hema Gupta, and Anuradha a. "DIRECT COMPRESSIBLE AND CO-PROCESSED EXCIPIENTS- A REVIEW." International Journal of Advanced Research 10, no. 04 (2022): 1008–13. http://dx.doi.org/10.21474/ijar01/14637.

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The demands on the functionality of excipients are increasing day by day because of the emergence of high-speed tableting machines and the use of direct compression methods for tableting. Direct compressible is the preferred method for the preparation of tablet. Excipient play an important role in formulating a dosage form. these are the ingredient which along with active pharmaceutical ingredient make up the dosage forms. Excipient act as protective agent, bulking agent and can also be used sources of excipients along with their uses, and these Can be used for different activities. The curren

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21

Tomar, Monika, and Amit Raj Sinha. "A technical note: Characterization and evaluation of novel, ready to use co-processed excipient in nutraceutical herbal vitamin and amino acid formulations." GSC Biological and Pharmaceutical Sciences 11, no. 2 (2020): 233–41. https://doi.org/10.5281/zenodo.4274547.

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A tablet is composed of different excipients and drug. All excipients have different properties with applications. Excipients are used to provide bulk and help to bind API into a dosage form, excipient should be inert in nature with respectable physical properties. Because the physical properties play a very important role during tablet compaction. However, maximum individual excipients do not have enough physical properties especially flowability. To fulfil these requirements co-processed excipient have been starting to use in formulation industries to make tablet and capsules. All co-process

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22

Sorathia, Kishorkumar, Mehul Patel, Tejal Soni, and B. N. Suhagia. "Directly Compressible Sustained Release Matrix Tablets of Losartan Potassium via Crystallo-co-agglomeration." Indo Global Journal of Pharmaceutical Sciences 13, no. 13 (2023): 13–21. http://dx.doi.org/10.35652/igjps.2023.13002.

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Background: Losartan potassium possesses poor bioavailability due to low elimination half-life and so requires to be developed as sustained release dosage form. Objectives: The present study was intended to prepare directly compressible sustained release matrix tablets of losartan potassium using hydrophilic polymer. Methods: Directly compressible agglomerates of drug were prepared by crystallo-co-agglomeration technique employing HPMC K100M as release retardant polymer. Prepared agglomerates were subjected for evaluation of flow, packing and compaction properties. Morphology of spherical aggl

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Kaur, Manpreet, Amit Mittal, Monica Gulati, Deepika Sharma, and Rajesh Kumar. "Formulation and in vitro Evaluation of Fast Dissolving Tablets of Febuxostat Using Co-Processed Excipients." Recent Patents on Drug Delivery & Formulation 14, no. 1 (2020): 48–62. http://dx.doi.org/10.2174/1872211314666191224121044.

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Background: Febuxostat is a novel, orally-administered, powerful, non-purine, xanthine oxidase inhibitor used for treating gout and ceaseless tophaceous gout. The drug exhibits low bioavailability (about 49%) which is ascribed to its dissolution rate-limited absorption. Objective: The current work is aimed to provide a novel strategy to improve the dissolution profile and thus, the bioavailability of Febuxostat. Methods: Formulation of Fast Dissolving Tablets (FDT) is anticipated to provide immediate release of the drug, which in turn, will improve its dissolution profile to provide the initia

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Mohammed, Boma, Zwanden Sule Yahaya, and Danjuma Mallam. "Diluent performance of a three component co-processed excipient for formulating ibuprofen tablets by wet granulation." Journal of Current Biomedical Research 2, no. 5, September-October (2022): 490–502. http://dx.doi.org/10.54117/jcbr.v2i5.7.

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Pharmaceutical tablets ingested orally remain the most popular dosage form in drug delivery, while the most frequently used route for administration of therapeutic agents remains the oral route. Recently, excipient development comprising a mixture of two or more materials assembled in a single frame by means of particle engineering, known as co-processed excipients, has gained enormous popularity. To prepare ibuprofen tablets by co-processing and wet granulation method and evaluate its diluent property. From the design of experiment (DOE), the optimized composition was obtained and ibuprofen g

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Senthil, S. P. "FORMULATION AND INVITRO EVALUATION OF MOUTH MELTING TABLETS OF TELMISARTAN USING NATURAL SUPERDISINTEGRANT." YMER Digital 21, no. 03 (2022): 300–312. http://dx.doi.org/10.37896/ymer21.03/33.

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This tablet is formulated by direct compression method by using natural superdisintegrant such as Hibiscus and Fenugreek for the benefits of agents which make the drug disintegrate rapidly in water by wicking or swelling or by any other mechanisms This type of property in dosage form can be attained by addition of different excipients, from which disintegrant is the key adjuvant. In recent years, several newer agents have been developed known as superdisintegrants. Diverse categories of superdisintegrants such as synthetic, semisynthetic, natural and co-processed blends etc. have been employed

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Choudhari, Prashant Kumar, H. K. Jain, P. Sharma, and B. Srivastava. "A novel co-processed directly compressible release-retarding polymer: In vitro, solid state and in vivo evaluation." Future Journal of Pharmaceutical Sciences 4, no. 1 (2018): 29–40. http://dx.doi.org/10.1016/j.fjps.2017.07.004.

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K.Ashok, *. and M.V. Nagabhushanam. "DESIGN AND EVALUATION OF SPHERICAL AGGLOMERATED CRYSTALS LOADED FAST DISOLVING TABLETS FOR ENHANCING THE SOLUBILITYOF MEFENAMIC ACID." Indo American Journal of Pharmaceutical Sciences 04, no. 11 (2017): 4610–16. https://doi.org/10.5281/zenodo.1069481.

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The objective of the present work was to study the effect of different polymers on the solubility and dissolution rate of Mefenamic acid a poorly water soluble NSAIDs, by spherically agglomeration using methanol, water and dichloromethane as good solvent, poor solvent and bridging liquid, respectively. The quasi-emulsion solvent diffusion technique was used as a method for spherical agglomeration. Spherical agglomeration of Mefenamic acid were prepared by using Poloxomer -F338 and Gelucire 48/16 in the ratio of 1:0.5,1:0.75,1:1. The agglomerates were subjected to various physicochemical evalua

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M.Suresh, babu *. and T. E. Gopala Krishna murthy. "DESIGN AND CHARACTERIZATION OF SPHERICAL AGGLOMERATED CRYSTALS LOADED FAST DISOLVING TABLETS FOR ENHANCING THE SOLUBILITY OF SIMVASTATIN." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 04, no. 12 (2017): 5002–8. https://doi.org/10.5281/zenodo.1408036.

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In the present work an attempt was done to study the effect of different carriers on the solubility and dissolution rate of Simvastatin poorly water soluble drug, by spherically agglomeration using N,N-dimethylformamide, water and chloroform as good solvent, poor solvent and bridging liquid, respectively. The quasi-emulsion solvent diffusion technique was used as a method for spherical agglomeration. Spherical agglomeration of Simvastatin were prepared by using Poloxomer -F338 and Gelucire 48/16 in the ratio of 1:0.5,1:0.75,1:1. The agglomerates were subjected to various physicochemical evalua

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Dhaneshwar, Kumar Vishwakarma Jai Narayan Mishra Hema Gupta and Anuradha. "DIRECT COMPRESSIBLE AND CO-PROCESSED EXCIPIENTS- A REVIEW." April 29, 2022. https://doi.org/10.5281/zenodo.6605443.

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The demands on the functionality of excipients are increasing day by day because of the emergence of high-speed tableting machines and the use of direct compression methods for tableting. Direct compressible is the preferred method for the preparation of tablet. Excipient play an important role in formulating a dosage form. these are the ingredient which along with active pharmaceutical ingredient make up the dosage forms. Excipient act as protective agent, bulking agent and can also be used sources of excipients along with their uses, and these Can be used for different activities.

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Swami, Arti, Prajakta Chavan, Shivani Chakankar, and Amol Tagalpallewar. "A Review on Multifunctional Excipients with Regulatory Considerations." Journal of Pharmaceutical Research International, October 5, 2021, 189–201. http://dx.doi.org/10.9734/jpri/2021/v33i45b32796.

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The practice of multifunctional excipients is gaining more and more attention as it simplifies the process of drug formulation by substituting the necessity of using mixture of many excipients. The multifunctional excipients are the class of excipients which includes pre-–processed and co-processed excipients and it provides added functionalities to the formulation. Functionality of an excipient is a useful property which helps in manufacturing and improves quality as well as applicability of the material. Researchers have identified that single component excipients may not always give the req

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Salim, Ilyasu, Adeniji Kehinde Olowosulu, Abdulrahman Abdulsamad, et al. "Application of SeDeM Expert System in the development of novel directly compressible co-processed excipients via co-processing." Future Journal of Pharmaceutical Sciences 7, no. 1 (2021). http://dx.doi.org/10.1186/s43094-021-00253-z.

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Abstract Background Computer-aided formulation design is gaining fantastic attention in chemical engineering of high functionality pharmaceutical materials for dosage form manufacture. To accelerate development of novel formulations in a quality-by-design perspective, SeDeM Expert System preformulation algorithm was developed as a tool for the design of solid drug delivery systems and for prediction of direct compression manufacturability of solid formulations. This research aims to integrate SeDeM Expert System into particle engineering design space of co-processing of solid excipients to dev

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"A Novel Directly Compressible Co-Processed Excipient for Sustained Release Formulation." Journal of Applied Pharmaceutical Science, 2013. http://dx.doi.org/10.7324/japs.2013.3917.

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Paul, Subrata, Kaniz Fatema Asha, Israt Zerin Alam, Md Ashraf Ali, Md Elias Al-Mamun, and Md Bytul Mokaddesur Rahman. "Physicochemical reports of gliclazide-carplex solid dispersions and tablets prepared with directly compressible co-processed excipients." Heliyon, November 2023, e22899. http://dx.doi.org/10.1016/j.heliyon.2023.e22899.

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Woyna-Orlewicz, Krzysztof, Witold Brniak, Wiktor Tatara, et al. "Investigating the Impact of Co-processed Excipients on the Formulation of Bromhexine Hydrochloride Orally Disintegrating Tablets (ODTs)." Pharmaceutical Research, September 19, 2023. http://dx.doi.org/10.1007/s11095-023-03605-x.

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Abstract Purpose Orodispersible tablets (orally disintegrating tablets, ODTs) have been used in pharmacotherapy for over 20 years since they overcome the problems with swallowing solid dosage forms. The successful formula manufactured by direct compression shall ensure acceptable mechanical strength and short disintegration time. Our research aimed to develop ODTs containing bromhexine hydrochloride suitable for registration in accordance with EMA requirements. Methods We examined the performance of five multifunctional co-processed excipients, i.e., F-Melt® C, F-Melt® M, Ludiflash®, Pharmabur

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M., Kalyan Raj, Umesh Rao Vinay, and Sudhakar M. "Synthesis Characterisation and Evaluation of Co-Processed Wax Matrix Excipient for Controlled Release Tablets Formulation." International Journal of Bioengineering and Life Sciences 9.0, no. 5 (2015). https://doi.org/10.5281/zenodo.2660970.

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The work focuses on the development of a directly compressible controlled release co-processed excipient using melt granulation technique. Erodible wax matrix systems are fabricated in which three different types of waxes are co processed separately with Maize starch in different ratios by melt granulation. The resultant free flowing powder is characterized by FTIR, NMR, Mass spectrophotometer and gel permeation chromatography. Also, controlled release tablets of Aripiprazole were formulated and dissolution profile was compared with that of the target product profile given in Zysis patent (Pat

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Singh, Richa, Prashant Kumar, Rahul Chaudhary, Arun Kumar, Shiv Bahadur, and Garima Garg. "Development and Characterization of Novel co-processed excipients to enhance compressibility profile for Formulation of Tablet Dosage Form." Research Journal of Pharmacy and Technology, June 28, 2022, 2547–51. http://dx.doi.org/10.52711/0974-360x.2022.00426.

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The present work deals with the development of a novel co-processed excipients using melt- granulation technique that would serve as an inbuilt multifunction adjuvant and can be used for the preparation of tablet as solid dosage form with poorly compressible drugs like Paracetamol, Diclofenac, and Ibuprofen etc. by direct compression method. In the formulation DCP (Dicalcium phosphate) and Potato Starch were used as a filler in 2:1 ratio; Croscarmellose as a superdisintegrant and 20% w/v PEG 6000 (polyethylene glycol) as a binder, to develop the co-processed excipient. This resulted in formati

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Olubunmi, Olayemi J., Aghogho N. Diemuku, Onyinyechi P. Obidiro, and Sylvester O. Eraga. "Evaluation of the effects of co-processed <I>Manihot Esculenta</I> starch on the tablet properties of directly compressed diclofenac and paracetamol formulations." Journal of Phytomedicine and Therapeutics 23, no. 1 (2024). http://dx.doi.org/10.4314/jopat.v23i1.5.

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Advancements in tablet manufacture has increased the demand for versatile excipients with multifunctional applications. Co-processing is fast evolving into the tool for development of these excipients with unique functional properties. The aim of this study is to evaluate the effect of co-processed Manihot esculenta starch and povidone on tablet properties of diclofenac and paracetamol formulations. Starch extracted from Manihot esculenta tubers was modified either by pre-gelatinization or gelatinization and then co-processed by co-dispersion with povidone to yield EXP-A and EXP-B respectively

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Bhatia, Vishal, Ashwani K. Dhingra, Rameshwar Dass, Bhawna Chopra, and Kumar Guarve. "Formulation Development and in-vitro Evaluation of Escitalopram Fast Dissolving Tablets." Central Nervous System Agents in Medicinal Chemistry 22 (June 24, 2022). http://dx.doi.org/10.2174/1871524922666220624113719.

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Background: Escitalopram, a selective serotonin reuptake inhibitor (SSRI), acts by increasing the serotonin level in the brain and is used widely for the management of depression and anxiety disorders. However, the poor dissolution rate of escitalopram due to less water solubility is a consequential problem confronting the pharmaceutical industry in developing pharmaceutical dosage forms for oral delivery systems. Objective: The present work aims to deliver a novel formulation for improving the dissolution profile and, thus, the bioavailability of escitalopram. Methods: Fast Dissolving Tablets

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B patil, Avanti. "Formulation and Evaluation of Co-Processed Excipient." Open Access Journal of Pharmaceutical Research 6, no. 1 (2022). http://dx.doi.org/10.23880/oajpr-16000265.

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The main purpose of the current review article is to provide a comprehensive overview of the latest developments in assistive technology and the mechanisms involved in the development of those assistants. Architectural scientists have observed that paramedics do not always provide the functionality needed to allow certain active ingredients to be made or performed properly and to focus their attention on producing multi-functional aids with advanced performance to meet the needs of pharmacists in terms of conditions of production costs, improved excipient performance and quality of tablets. Ch

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Kumar, K. Sampath, D. Maheswara Reddy, Y. Dastagiri Reddy, J. Balanarasimha Goud, and Abdul Basith. "Development and Evaluation of Mouth Dissolving Tablets of Montelukast Sodium Using Co-processed Excipients." Journal of Pharmaceutical Research International, March 20, 2021, 21–29. http://dx.doi.org/10.9734/jpri/2021/v33i1431271.

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Background: The concept of formulating ODT containing montelukast sodium offers an appropriate, practical approach to accomplish fast release of the drug. Absorption of these tablets takes place directly into the systemic circulation which bipass the hepatic first-pass metabolism of montelukast sodium which ultimately results in the improvement in the bioavailability. Method: In the present study ODT tablets of montelukast sodium were prepared by using different Superdisintegrants like natural and synthetic (tulasi, hibiscus, orange peel powder, Ispaghula, banana peel powder, Crospovidon

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