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Journal articles on the topic 'Directors of the Poor'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 July 2025

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1

Nowland, John, and Andreas Simon. "Is poor director attendance contagious?" Australian Journal of Management 43, no. 1 (2017): 42–64. http://dx.doi.org/10.1177/0312896217702426.

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Recent corporate governance guidelines have focused on the structure of the board of directors, with little recognition of the importance of director attendance at board and committee meetings. Director attendance is vital as prior studies show that director absences result in weaker monitoring of management and lower firm performance. This study examines whether directors learn from the attendance behavior of their board colleagues, thereby magnifying the scope and potential consequences of good or poor attendance practices. We find that director attendance is significantly positively related

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Meiliana, Meiliana, and Iven Julia. "Analisis Pengaruh Struktur Dewan Direksi terhadap Kinerja Perusahaan." Global Financial Accounting Journal 6, no. 1 (2022): 170. http://dx.doi.org/10.37253/gfa.v6i1.6683.

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Purpose - This study aims to determine the effect of the board structure on company performance. This study has 6 independent variables, which consist of the size of the board of directors, independent directors, board of directors meetings, board of directors education, female directors, and managerial ownership. Research Method - The sample used in this research is quantitative data with a purposive sampling technique. Based on the criteria, the samples collected from 473 companies in the period 2014-2018. The sample data is tested using panel data regression. Findings - This stu

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Carla, Juaçaba. "Pobre belleza = Poor beauty." rita_ Revista Indexada de Textos Académicos, no. 16 (October 31, 2021): 40–55. https://doi.org/10.24192/2386-7027(2021)(v16)(03).

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Esta investigación se centra en un principio estético que inició en 1960 el director teatral polaco Jerzy Grotowski, en el que definió su teatro como "Teatro Pobre". Al mismo tiempo que el director de teatro inglés Peter Brook ha iniciado un proceso de búsqueda de un teatro esencial. Ambos directores repiensan el espacio teatral y su relación con el espectador, al entenderlo como un espacio democrático. Revisamos estos conceptos en el momento actual para volver a pensar en el significado de un lenguaje esencial, desde un sentido

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Dandira, Martin. "Executive directors' contracts: poor performance rewarded." Business Strategy Series 12, no. 3 (2011): 156–63. http://dx.doi.org/10.1108/17515631111130121.

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Liu, Claire, Angie Low, Ronald W. Masulis, and Le Zhang. "Monitoring the Monitor: Distracted Institutional Investors and Board Governance." Review of Financial Studies 33, no. 10 (2020): 4489–531. http://dx.doi.org/10.1093/rfs/hhaa014.

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Abstract Boards are crucial to shareholder wealth. Yet little is known about how shareholder oversight affects director incentives. Using exogenous shocks to institutional investor portfolios, we find that institutional investor distraction weakens board oversight. Distracted institutions are less likely to discipline ineffective directors with negative votes. Consequently, independent directors face weaker monitoring incentives and exhibit poor board performance; ineffective independent directors are also more frequently appointed. Moreover, we find that the adverse effects of investor distra

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Grove, Hugh, Mac Clouse, and Tracy Xu. "Benchmarking boards of directors for better corporate governance." Corporate Board role duties and composition 16, no. 2 (2020): 8–18. http://dx.doi.org/10.22495/cbv16i2art1.

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The key question and major lessons learned in this research are that individual companies and their boards of directors could use the board director benchmarking information compiled in the Conference Board Report to assess their own boards of directors’ corporate governance practices. For an initial benchmarking approach, this paper compared a poor long-term market performance company (Grove & Clouse, 2019) with a strong long-term market performance company (Grove & Lockhart, 2019). The following benchmarked differences in the boards of directors of these two companies were key succes

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Hoitash, Udi, and Anahit Mkrtchyan. "Recruiting the CEO from the Board: Determinants and Consequences." Journal of Financial and Quantitative Analysis 53, no. 3 (2018): 1261–95. http://dx.doi.org/10.1017/s002210901800011x.

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We investigate an increasingly prevalent CEO succession strategy: recruiting CEOs from the board of directors (director–CEOs). Director–CEOs might be hired in a planned succession because they combine outsiders’ new perspectives with insiders’ firm-specific knowledge. Alternatively, directors may be recruited when the board is unprepared for a leadership change. We find that unplanned successions, in which director–CEOs are appointed as a “quick-fix” solution, result in a negative market reaction, deterioration in performance, and ill-fitting candidates with shorter tenures. Conversely, firms

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Samin, Samin, and Satria Yudhia Wijaya. "IMPLIKASI KINERJA DAN INDEPENDENSI DEWAN DIREKSI TERHADAP KECENDERUNGAN PERUBAHAN STRATEGI PERUSAHAAN." Equity 18, no. 2 (2019): 105. http://dx.doi.org/10.34209/equ.v18i2.462.

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This study examined the implications of the firm financial performance and composition of indepedencies the board of directors tendency to change strategy. Firm financial performance parameters used in this research include : total assets, profitability, and leverage, while measuring changes in the company’s strategy is the implementation of low cost and differentiation. The sample of this research consisted of 26 companies in the Indonesia Stock Market with the data period 2009-2012. Hypothesis testing techniques using logistic regression. When company suffered in poor performance become poss

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Burns, Natasha, Kristina Minnick, and Kartik Raman. "Director Industry Expertise and Voluntary Corporate Disclosure." Quarterly Journal of Finance 10, no. 03 (2020): 2050012. http://dx.doi.org/10.1142/s2010139220500123.

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We examine if firms with directors with related industry expertise (DRIs), or directors that are supply chain partners, exhibit a greater propensity to forecast earnings, and improve the specificity and accuracy of forecasts. Using instrumental variables to mitigate endogeneity, we find that DRIs and supply chain partners possess unique insights which improve managerial forecasts especially when there is greater earnings uncertainty (innovations along the supply chain, poor performance, operating in volatile industries). We use director deaths as exogenous shocks to board composition and confi

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Aljaaidi, Khaled S., and Neef F. Alwadani. "Audit report delay: Does directors’ busyness matter?" Journal of Governance and Regulation 12, no. 3 (2023): 112–19. http://dx.doi.org/10.22495/jgrv12i3art12.

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Fich and Shivdasani (2006) argue that active boards of directors with many external members have poor corporate governance. According to Al-Ajmi (2008), the primary source of information for shareholders in developing countries is financial reporting. This study aims at investigating the connection between director busyness and timely financial reporting. The sample includes 510 non-financial Saudi companies listed on the Saudi Stock Exchange (Tadawul). This study uses the busyness hypothesis, rooted in the agency theory, to explain the relationship between board busyness and audit report dela

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Volpe, Virginia Olivia, Nicole D. Vincelette, Onyee Chan, et al. "High MYC Expression Predicts Poor Survival Outcomes in IDH1/2 Mutant AML Patients." Blood 138, Supplement 1 (2021): 2377. http://dx.doi.org/10.1182/blood-2021-147030.

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Abstract Background In AML, IDH1/2 somatic mutations can be frequent in patients at about 20%. Physiologically, IDH1/2 catalyze isocitrate conversion to alpha-ketoglutarate (α-KG). α-KG is an activating co-factor for ten-eleven translocation 2 (TET2), an important epigenetic regulator which converts 5mC to 5hmC in the genomic DNA ultimately turning on the myeloid differentiation. In contrast, mutant IDH1/2 proteins promote α-KG conversion to 2-hydroxyglutarate (2-HG), an onco-metabolite. In pre-clinical studies, 2-HG inhibits TET2 activity by suppressing 5mC-to-5hmC conversion and thus allowin

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Borhan Uddin Bhuiyan, Md, and Jill Hooks. "Operational “problem” directors and environmental performance." Sustainability Accounting, Management and Policy Journal 7, no. 2 (2016): 268–94. http://dx.doi.org/10.1108/sampj-12-2014-0088.

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Purpose The way in which a firm’s actions are perceived by others is driven by the individual values and ethics of directors (Ntim and Soobaroyen, 2013). The purpose of this paper is to examine the effects of “problem” directors on the environmental performance of firms. The authors argue that if a board member has a tainted reputation, then environmental performance will be higher as the problem director seeks to rebuild his/her reputation. Design/methodology/approach The authors use a sample of the top 500 US companies for 2010 and 2011 and an ordinary least square (OLS) model to capture the

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Khotchasing, Wassana, and Somchit Jaruratanasirikul. "Work Director’s Evaluation and Self-Evaluation of Professional Performance of Pediatricians Graduated from Prince of Songkla University." Songklanagarind Medical Journal 35, no. 3 (2017): 205. http://dx.doi.org/10.31584/smj.2017.35.3.730.

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Objectives: To compare the work performance of 2004-2013 Prince of Songkla University (PSU) pediatric residencytraining graduates as evaluated by their workplace directors and the graduates self-evaluation.Material and Method: All 78 pediatric graduates from PSU 2004-2013 were located: 52 (66.7%) were in the publicsector and 26 (33.3%) in the private sector. Ten-item performance evaluation questionnaires were sent to both thegraduates and their workplace directors. A rubric scale was used for rating each item from 1 to 10 (1=very poor, 10=excellent). The workplace director was asked to give an

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Li, Zekun, Zhenping Chen, Xiaoling Cheng, et al. "Low-Dose Immune Tolerance Induction for Hemophilia a Children with Poor-Risk High-Titer Inhibitors." Blood 134, Supplement_1 (2019): 1122. http://dx.doi.org/10.1182/blood-2019-132021.

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Background: Low-dose immune tolerance induction (ITI) +/- immunosuppression as a practical ITI strategy in China showed a relatively satisfactory success rate and economic advantages in pilot study. However, the outcome still needs to be verified by larger cohort. Aim: To report the efficacy of this low-dose ITI +/- immunosuppression strategy in hemophilia A children ≥ 10 BU. Methods: This was a single center, prospective study in 53 hemophilia A subjects from Sep 2016 to Apr 2019. All subjects having ≥ 10 BU receiving ~50IU/kg FVIII every other day using domestic intermediate purity pdFVIII/V

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Pollyea, Daniel A., Keith W. Pratz, Andrew H. Wei, et al. "Outcomes in Patients with Poor-Risk Cytogenetics with or without TP53 Mutations Treated with Venetoclax Combined with Hypomethylating Agents." Blood 138, Supplement 1 (2021): 224. http://dx.doi.org/10.1182/blood-2021-145639.

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Abstract Introduction Patients (pts) with acute myeloid leukemia (AML) with poor-risk cytogenetics at diagnosis have inadequate responses to standard treatment. Pre-clinical and clinical data show that TP53mutation (mut) is associated with poor outcomes with venetoclax (Ven). However, the clinical impact of AML with poor-risk cytogenetics with and without a TP53 mut treated with a hypomethylating agent (HMA) and Ven is unknown. Herein, we evaluated the efficacy and safety of the Ven + azacitidine (Aza) or HMA combination in pts with treatment-naïve AML with poor-risk cytogenetics with TP53wt o

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Agrawal, Anup, and Mark A. Chen. "Boardroom Brawls: An Empirical Analysis of Disputes Involving Directors." Quarterly Journal of Finance 07, no. 03 (2017): 1750006. http://dx.doi.org/10.1142/s2010139217500069.

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We investigate the internal workings of US corporate governance with a hand-collected dataset of director resignations that are related to power struggles within the board. About two-thirds of the conflicts arise because of how board members interact in carrying out their duties, while most of the remaining cases involve disagreements between directors and top management over corporate strategy or financial policy. Conflicts are more likely to occur at companies where the CEO is the founder or is relatively new to the position. Tensions also increase when there are independent directors with l

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Guidez, Stéphanie, Guillemette Fouquet, Hélène Demarquette, et al. "Impact of Poor Tolerance and Discontinuation of the Dexamethasone during Treatment with Lenalidomide-Dexamethasone in Relapsed and Refractory Multiple Myeloma." Blood 126, no. 23 (2015): 5379. http://dx.doi.org/10.1182/blood.v126.23.5379.5379.

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Abstract Background. Lenalidomide plus Dexamethasone is approved at first relapse and beyond in Europe, and has transformed the prognosis of Myeloma in the relapse setting. Lenalidomide plus Dexamethasone is approved until progression, that could last for years, the median PFS in phase 3 studies being at 17 months at first relapse, but many patients eventually reach 5 to 7 years these days. Dexamethasone was showed to enhance lenalidomide-antitumor efficacy and to prolong the progression-free survival. However, long term exposure to dexamethasone is also known to be associated to an array of a

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Martello, Marina, Rosalinda Termini, Enrica Borsi, et al. "A Maturation Index Defines Newly Diagnosed Multiple Myeloma Patients with Advanced Immunophenotypic and Molecular Differentiation Profiles Associated with Poor Prognosis." Blood 134, Supplement_1 (2019): 1797. http://dx.doi.org/10.1182/blood-2019-129975.

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Introduction The differentiation status plasticity of Multiple Myeloma (MM) plasma cells (PCs) is an adaptive strategy that might confer a specific fitness to tumour cells, enabling their interaction with an evolving microenvironment. Therefore, proliferation rates of MM clones are not constant, and the immunophenotypic profile of the most skilled MM PCs might be the expression of specific genetic and genomic programs, that emerge under the therapeutic pressure and promote tumour development. However, the genomic background that supports any diverse plasma cell differentiation phenotypes has n

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White, Susan, and Carlos J. O. Trejo-Pech. "Farmer Brothers Company Proxy Contest: A Corporate Governance Case Study." International Journal on Food System Dynamics 13, no. 1 (2022): 100–114. https://doi.org/10.18461/ijfsd.v13i1.a7.

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In 2019, Farmer Brothers, a coffee and tea producer and distributor, was facing its second challenge to its board of directors from dissident founding family shareholders, who no longer held a controlling interest in the firm. Farmer Brothers defeated its first proxy contest in 2016, with shareholders and a major shareholder advising firm, International Shareholder Services, endorsing management. Since then, the performance of the company had declined, and its CEO replaced in May 2019. A new set of dissenting shareholders included the granddaughter of founder Roy Farmer and a former board of d

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de Almeida, Jose Elias Feres. "An exploration of boards of directors’ quality: The development of an index for directors attributes and the relation with firm value and performance." Corporate Board role duties and composition 7, no. 2 (2011): 51–63. http://dx.doi.org/10.22495/cbv7i2art4.

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In an environment with poor quality of Corporate Governance Mechanisms, the quality of directors’ attributes might exert an important role to improve firm’s value and performance. I developed an index to explore the quality of Board of Directors based on Brazilian and international corporate governance codes to measure directors qualitative attributes. The sample consist in 24 Brazilian firms that traded at NYSE in the period over 1999-2006. The results show us that board of directors with high types of attributes can improve value measured individually and by the quality index. The main resul

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Chan, Onyee, Najla Al Ali, Hammad Tashkandi, et al. "Mutations Highly Specific for Secondary AML Are Associated with Poor Outcomes in Patients with NPM1-Mutated ELN Favorable Risk AML." Blood 138, Supplement 1 (2021): 686. http://dx.doi.org/10.1182/blood-2021-150759.

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Abstract Background: NPM1 is commonly mutated in acute myeloid leukemia (AML) and represents a distinct entity under the WHO 2016 classification. It is one of the few mutations that can potentially support favorable risk by European LeukemiaNet (ELN) 2017 criteria. Mutations that are highly specific for secondary AML including SRSF2, SF3B1, U2AF1, ZRSR2, ASXL1, EZH2, BCOR, and STAG2 (sMut) (Lindsley et al.) have been shown to confer poor prognosis. The impact of these mutations on NPM1-mutated AML warrants further investigation. Objective: In this study, we explore the outcomes in patients wit

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Belkhir, Mohamed. "Board of directors' size and performance in the banking industry." International Journal of Managerial Finance 5, no. 2 (2009): 201–21. http://dx.doi.org/10.1108/17439130910947903.

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PurposeThis paper aims to investigate the relationship between board size and performance in a sample of 174 bank and savings‐and‐loan holding companies, over the period 1995‐2002.Design/methodology/approachIn order to examine the relationship between board of directors' size and performance in the banking industry, the paper uses various statistical tools, including panel univariate analyses and panel data techniques.FindingsContrary to theories predicting that smaller boards of directors are more effective, increasing the number of directors in banking firms does not undermine performance. I

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Joffe, Erel, Anita Kumar, Serena Zheng, et al. "Genomic Profiling of Mantle Cell Lymphoma Suggests Poor-Risk Profile Is Present at Diagnosis and Does Not Arise By Tumor Evolution." Blood 134, Supplement_1 (2019): 22. http://dx.doi.org/10.1182/blood-2019-129563.

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INTRODUCTION Despite major clinical advancements, mantle cell lymphoma (MCL) remains a therapeutic challenge with a considerable number of patients experiencing a dismal course. We sought to map the genomic landscape of MCL at diagnosis and at disease progression. We aimed to identify genomic drivers of aggressive phenotype, resistance and relapse and to characterize the genomic evolution of this disease. METHODS We evaluated the genetic landscape of 210 MCL patients, comparing patients sequenced pretreatment (pre-Tx) to those sequenced at disease progression (POD), including 23 patients with

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Nishat, Mohammed, and Rozina Shaheen. "Corporate governance and firm performance in an emerging market - An exploratory analysis of Pakistan." Corporate Ownership and Control 4, no. 2 (2007): 216–25. http://dx.doi.org/10.22495/cocv4i2c1p6.

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This preliminary study aims to develop a corporate governance index based on governance practices followed by the listed firms at Karachi Stock Exchange (KSE). Since the corporate governance concept is at very initial level of its implementation and practices, this study also analyses the structure of good corporate governance practices and level of awareness about new regulations of corporate governance implemented by Security Exchange Commission of Pakistan. The data is collected through a structured questionnaire covering seven corporate governance categories: audit committee, board of dire

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Barone, Gerhard, Kent Hickman, and Mark Shrader. "Board Changes in Response to Extremes in Performance." Journal of Finance Issues 10, no. 2 (2012): 24–29. http://dx.doi.org/10.58886/jfi.v10i2.2310.

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This study contrasts changes in board structure in firms at the extremes of industryadjusted performance. We find pervasive changes in board size, composition, and director pay for firms whose stock market performance ranks in the uppermost and lowest deciles of industryadjusted returns over the period 2001-2005. Our evidence shows that these companies tended to change their board’s size, added outsiders to the board, and increased director pay. Significant differences between the two groups are documented, with poor performers making more dramatic changes in all three of these governance metr

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Bhatnagar, Bhavana, Qiuhong Zhao, James L. Fisher, et al. "Poor Treatment Outcomes of Young (<60 Years) African American Patients (Pts) Diagnosed with Acute Myeloid Leukemia (AML) (Alliance)." Blood 136, Supplement 1 (2020): 5–7. http://dx.doi.org/10.1182/blood-2020-140999.

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Background: AML is a clinically and molecularly heterogeneous disease associated with poor survival. Multiple disease-related factors including cytogenetic findings and gene mutations, as well as patient-related factors, such as demographics and African American (AA) heritage, have been identified that impact on pt outcomes. However, with recent improved survival it is unknown whether racial health disparities persist. Moreover, we are not aware of a large study that assessed possible race-associated molecular differences. Thus, the goals of our study were to 1) analyze the outcomes of adult A

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Pemmaraju, Naveen, Hagop M. Kantarjian, Joseph David Khoury, et al. "Outcomes in Patients with Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN): Longer-Term Follow-up Demonstrates Poor Outcomes in Patients with Skin-Only Presentation." Blood 132, Supplement 1 (2018): 3980. http://dx.doi.org/10.1182/blood-2018-99-119888.

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Abstract Background: Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) is a rare, distinct myeloid malignancy with historically poor survival, a high transformation rate to acute myeloid leukemia (AML), and no standard of care therapeutic approach. It is characterized by the overexpression of CD123+/IL3Rα, BCL-2 overexpression, and splicing factor abnormalities. BPDCN most commonly affects: skin, bone marrow (BM), and lymph node (LN). We sought to determine the outcomes of pts with BPDCN with focus on compartment of disease [(skin vs BM) at presentation. Patient Characteristics: We included

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Luo, Yi, Sheng Qiang He, Liang Jiang Wang, and Zong Bo Zhang. "Study on Ultrasonic Fusion Bonding for Polymer Microfluidic Chips." Key Engineering Materials 483 (June 2011): 311–15. http://dx.doi.org/10.4028/www.scientific.net/kem.483.311.

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Ultrasonic fusion bonding is a potential method for mass-production of polymer microfluidic chips. However, the micro structures in the chips are easily damaged or even destroyed due to poor controllability and uniformity of the melted energy directors in ultrasonic bonding process. In this paper, a novel micro joint including energy directors and flow blocks is presented. The flow profile of the melted energy directors is controlled by the dimensions of the flow blocks, auxiliary energy-equilibrating structures are also designed to prevent the uneven melt of energy directors. Polymethyl metha

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Stein, Guido, Manuel Gallego, and Marta Cuadrado. "CEO succession and proprietary directors: evidence from Spanish listed firms." Corporate Ownership and Control 11, no. 1 (2013): 140–46. http://dx.doi.org/10.22495/cocv11i1conf2p5.

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This study advances research on CEO succession and board monitoring of senior executives by examining how proprietary directors can affect the probability of CEO dismissal. Drawing on our newly developed database covering all CEO successions occurring in all Spanish listed firms during the period 2007–2010, we propose that proprietary directors may increase the board’s monitoring efforts over the chief executive, forcing him to resign in situations of poor performance. Hypotheses are tested longitudinally, using CEO succession data taken from 111 publicly-traded firms in the Spanish ‘mercado c

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Grassi, Laura, Marco Giorgino, Raimondo Simona, and Giorgio Romani. "The induction of board directors: a case study perspective." Corporate Ownership and Control 13, no. 4 (2016): 207–23. http://dx.doi.org/10.22495/cocv13i4c1p6.

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This paper gives an overview on the induction process for board members with a focus on the Italian context. First, considering the limited prior academic literature, we contribute to the understanding of the induction term. We propose a multilevel theoretical framework that synthesizes and integrates the poor and contrasting prior literature on the definition and the attendees of the program. We posit that the process is intended for all the appointed directors as it is tailored and specific of each company, due to the peculiar environment in which the firm operates. Second, we investigate ho

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Gillman, L. M., A. Vergis, J. Park, and M. Taylor. "53. Resident training and the dictated operative report - A national perspectives." Clinical & Investigative Medicine 30, no. 4 (2007): 56. http://dx.doi.org/10.25011/cim.v30i4.2814.

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Operative dictation training is a poorly studied area of surgical resident education and there is currently no literature on the national experience with operative dictation training in Canada. We therefore undertook a web-based survey of residents and program directors in general surgery training programs in Canada to determine if there is an ongoing desire for formal operative dictation training.  Every resident and program director in English speaking General Surgery programs in Canada was contacted by email and asked to participate in the study. A secure, web based survey program was

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Qian, Aimin, and Jingyan Li. "Effect of Appointed Directors on Corporate Carbon Emission Intensity: Evidence from Mixed-Ownership Reform in Chinese Private Industrial Enterprises." Sustainability 16, no. 13 (2024): 5662. http://dx.doi.org/10.3390/su16135662.

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The growing prominence of global warming has led to a worldwide consensus on the need to reduce carbon emissions. Employing a sample of private industrial enterprises listed on the Chinese stock market from 2008 to 2021, this study explores the effect of directors appointed by non-controlling state shareholders (appointed directors), which is a growing type of mixed-ownership reform, on corporate carbon emission intensity. The results show that appointed directors significantly reduce corporate carbon emission intensity. Mechanism tests suggest that this reduction is achieved through developin

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Shah, Parth, Anil Aktas-Samur, Mariateresa Fulciniti, et al. "Presence of Extrachromosomal DNA (ecDNA) Impacts Both Progression Free and Overall Survival and Is an Independent Poor Prognostic Marker in Multiple Myeloma." Blood 138, Supplement 1 (2021): 461. http://dx.doi.org/10.1182/blood-2021-151647.

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Abstract Background Focal amplifications and rearrangements drive tumor growth and evolution in cancer. Focally amplified regions often involve the juxtaposition of rearranged segments of DNA from distinct chromosomal loci into a single amplified region and nearly half of these regions can be explained by circular, extrachromosomal DNA (ecDNA) formation. Cancer-associated ecDNA shows a unique circular placing ecDNA at the interface of cancer genomics and epigenetics. As formation of ecDNA represents a manifestation of genomic instability, we have investigated presence and prognostic impact of

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Padella, Antonella, Giovanni Marconi, Giorgia Simonetti, et al. "Higher Expression of PALB2 Predict Poor Prognosis in AML Patients and Identifies Potential Targets of Synthetic Lethal Therapies." Blood 132, Supplement 1 (2018): 1507. http://dx.doi.org/10.1182/blood-2018-99-118210.

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Abstract Background - Partner and localizer of BRCA2 (PALB2) plays a key role in the DNA damage repair (DDR). Genomic alterations of DDR genes rarely occur in AML, while their deregulation at transcriptional level is a known mechanism exploited by leukemic cells in order to sustain the high genetic instability and to continue proliferation. Aim - We aimed to characterize the role of PALB2 in AML by investigating its expression levels and its prognostic value, in order to evaluate its potential as target of therapies based on a synthetic lethality approaches. Methods - Gene expression profiling

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Labrador, Jorge, Miriam Saiz-Rodríguez, Maria Dunia De Miguel, et al. "Venetoclax Therapy in a Heavily Treated Cohort of Patients with Relapsed or Refractory Acute Myeloid Leukemia: Update of the Pethema Registry Experience." Blood 138, Supplement 1 (2021): 2325. http://dx.doi.org/10.1182/blood-2021-150231.

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Abstract Introduction The prognosis of patients with relapsed or refractory acute myeloid leukemia (RR-AML) is very poor, and treatment options are very limited. The exciting results of venetoclax (VEN) in untreated AML have led to its off-label use in RR-AML. However, evidence in RR-AML is still scarce and the available data are mostly from retrospective and single-center studies. The aim of our study was to analyze the effectiveness of VEN use in patients with RR-AML reported to the PETHEMA AML epidemiological registry. Initial results were presented previously (Labrador J, et al. ASH 2020).

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Beattie, Vivien, Robin Roslender, and Sarah Jane Smith. "Balancing on a Tightrope: Customer Relational Capital, Value Creation and Disclosure." FINANCIAL REPORTING, no. 3 (June 2014): 19–52. http://dx.doi.org/10.3280/fr2013-003003.

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This paper documents and compares the perceptions of key functional specialists regarding the contribution of 16 customer relational capital components to value creation and the motivations underlying its external disclosure. Findings of questionnaire surveys to samples of UK listed company marketing directors (who create customer relational capital) and finance directors (who report customer relational capital) are supplemented by follow-up interviews. Marketing directors and finance directors broadly agreed on the relevant importance of the components to value creation. While companies attem

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Sharpe, Nicola. "Volkswagen's Bad Decisions & Harmful Emissions: How Poor Process Corrupted Codetermination in Germany's Dual Board Structure." Michigan Business & Entrepreneurial Law Review, no. 7.1 (2017): 49. http://dx.doi.org/10.36639/mbelr.7.1.volkswagen.

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This Article directly challenges the often argued proposition that Germany's two-tier board of directors is superior to America’s single-tier board structure. It argues that regardless of structure, any decision-making body that lacks effective decision-making processes is at significant risk of failure, scandal, and ineffectiveness. Legal scholars and policymakers have largely ignored the connection between decision-making processes and the efficacy of corporate leadership. The Article is the first to examine this underexplored relationship in the context of the German dual-board. Volkswagen’

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Barwick, Benjamin G., Paola Neri, Nizar Bahlis, et al. "Immunoglobulin Lambda Translocations Identify Poor Outcome and IMiD Resistance in Multiple Myeloma and Co-Occur with Hyperdiploidy." Blood 132, Supplement 1 (2018): 405. http://dx.doi.org/10.1182/blood-2018-99-113585.

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Abstract Patients with the plasma cell malignancy multiple myeloma now benefit from treatments such as proteasome inhibitors, immunomodulatory imide drugs (IMiDs), autologous stem cell transplant, and monoclonal antibodies. However, 20% of patients still relapse or die within two years and are deemed 'high risk'. Current markers fail to identify all high-risk patients resulting in misdiagnoses, therefore additional markers for this deadly form of the disease are required. To better understand and identify high-risk myeloma, we analyzed the structural variant landscape of 826 myelomas from newl

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Sanyal, Abhijit, Joanna M. Hamilton, Ariel Martin, et al. "Using clinical pathways to prospectively identify poor prognosis cancer patients: A preliminary analysis." Journal of Clinical Oncology 39, no. 28_suppl (2021): 329. http://dx.doi.org/10.1200/jco.2020.39.28_suppl.329.

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329 Background: Cancer patients in the last year of life may have different clinical needs and evolving goals of care. Helping clinicians consistently identify such patients in a systematic and prospective fashion, at a discrete moment in the care trajectory, is an important step towards optimizing the care of these patients. Methods: Physician medical directors for each clinical pathway at our institution were tasked with identifying nodes within their respective treatment pathways associated with poor prognosis, specifically a median overall survival of < 12 months. This information was e

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Keane, Colm, Soi C. Law, Clare Gould, et al. "Elevated LAG-3 Expression in the Tumor Microenvironement of Patients with DLBCL Is Associated with a Non-GCB Phenotype and Poor Prognosis." Blood 132, Supplement 1 (2018): 1576. http://dx.doi.org/10.1182/blood-2018-99-112830.

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Abstract LAG3 is an immune checkpoint expressed on a variety of immune cells including a sub-population of 'exhausted' effector T cells and TREGs. Early-phase studies of anti-LAG3 mAb show promise in solid and haematological cancers. We have previously demonstrated LAG3 is enriched within the tumor microenvironment in Hodgkin Lymphoma (Gandhi et al. Blood 2006). Data in the aggressive B-cell lymphoma DLBCL is lacking. We used a conventional discovery/ validation approach in two population based Australian cohorts (discovery: Brisbane/Canberra; validation: Sydney) totalling 250 patients treated

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Derenzini, Enrico, Alessandra Rossi, Claudio Agostinelli, et al. "Integration of Nanostring Profiling and Functional Characterization of Oxidative and Replicative Stress Biomarkers Identifies Poor Prognosis MYC/BCL-2 Positive Diffuse Large B-Cell Lymphoma Subsets, Providing Opportunities for Precision Therapies." Blood 132, Supplement 1 (2018): 676. http://dx.doi.org/10.1182/blood-2018-99-118329.

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Abstract Diffuse large B-cell lymphoma (DLBCL) overexpressing MYC and BCL-2 have a poor outcome with standard therapies irrespective of the cell of origin (COO), representing an unmet medical need. Furthermore, precision therapy approaches specifically designed for MYC/BCL-2 positive DLBCL are lacking. Recently we reported that MYC positive DLBCL harbor high levels of inherent DNA damage and display constitutive activation of the DNA damage response (DDR) pathways, these alterations being correlated with poor outcome (Derenzini et al. Oncotarget 2015). In an effort to design specific therapies

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Cegelka, Derek, Victoria R. Wagner-Greene, and Jennifer Newquist. "Health Behaviors of Funeral Directors in the US: A Needs Assessment." American Journal of Health Behavior 44, no. 6 (2020): 864–75. http://dx.doi.org/10.5993/ajhb.44.6.10.

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Objectives: Little is known about the health-risk behaviors of funeral directors. We undertook a study to examine their health behavior risks by assessing perceived health behaviors. Methods: The study was a cross-sectional, descriptive study of a sample of funeral directors in the US as of September 2018. We used online survey software to disseminate a multi-wave survey to funeral directors. Results: Overall, we received 132 completed surveys (16.5% response rate). Overall, funeral directors rated themselves as healthy, but 61% reported that their mental health was not good in the previous 30

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Bertamini, Luca, Mariella Grasso, Mattia D'Agostino, et al. "Poor Prognosis of Multiple Myeloma Predicted By High Levels of Circulating Plasma Cells Is Independent from Other High-Risk Features but Is Modulated By the Achievement of Minimal Residual Disease Negativity." Blood 136, Supplement 1 (2020): 12–13. http://dx.doi.org/10.1182/blood-2020-137075.

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Background Despite an improvement in treatment response, high-risk multiple myeloma (MM) patients (pts) experience early relapse and short disease-free survival. Together with more validated high-risk features, high levels of circulating plasma cells (high CPC) have been considered a marker of aggressive disease and poor outcome (F. Gay et al, ASH 2019; W.I. Gonsalves et al, Am J Hematol 2020). To date, there are no uniform data on the optimal cut-off predictive of clinical outcome. No prospective data on CPC are available in the setting of novel-drug clinical trials with comprehensive baselin

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Fleming, Shaun, Cheng-Hong Tsai, Hartmut Döhner, et al. "Use of Machine Learning in 2074 Cases of Acute Myeloid Leukemia for Genetic Risk Profiling." Blood 134, Supplement_1 (2019): 1392. http://dx.doi.org/10.1182/blood-2019-128243.

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Background: Prognosis of Acute Myeloid Leukaemia (AML) is guided by chromosomal and molecular profiling. Standard regression approaches may not be optimal for identifying complex gene-gene interactions. Aims: We investigated use of machine-learning (ML) by recursive partitioning (RP) and random forest (RF) analysis on two large AML datasets to develop a hierarchical prognostic risk model. Methods: This study included 2074 non-APL AML cases aged ≤70 from National Taiwan University Hospital (NTUH; n=759) and the German-Austrian AML Study Group (AMLSG; n=1315)(Table 1). Statistical analysis perfo

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Kahan, Joseph B., Matthew Salzler, Danielle DiCenzo, Thomas Zink, Zachary Radford, and David Tybor. "High School Athletic Directors Report Poor Compliance With Concussion Reporting and Medical Clearance in Massachusetts." Arthroscopy, Sports Medicine, and Rehabilitation 2, no. 5 (2020): e563-e567. http://dx.doi.org/10.1016/j.asmr.2020.07.002.

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Bhuiyan, Md Borhan Uddin, and Jamal Roudaki. "Related party transactions and finance company failure: New Zealand evidence." Pacific Accounting Review 30, no. 2 (2018): 199–221. http://dx.doi.org/10.1108/par-11-2016-0098.

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Purpose This paper aims to examine the existence of related party transactions (RPTs) in failed financial companies in New Zealand when firms have interlocking directors on the board. We also examine the role of auditors in the review of RPTs. We anticipate that inter-company director relationships promote RPTs, while reputable large auditors (i.e. Big4) restrict the practice. Design/methodology/approach This study uses multivariate analysis to examine the determinants of RPTs. We use an unique, hand-collected database of New Zealand finance companies all of which collapsed during the years 20

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Hertzberg, Mark S., Maher K. Gandhi, Belinda Butcher, et al. "Early Treatment Intensification with R-ICE Chemotherapy Followed By Autologous Stem Cell Transplantation (ASCT) Using Zevalin-BEAM for Patients with Poor Risk Diffuse Large B-Cell Lymphoma (DLBCL) As Identified By Interim PET/CT Scan Performed after Four Cycles of R-CHOP-14: A Multicenter Phase II Study of the Australasian Leukaemia Lymphoma Study Group (ALLG)." Blood 126, no. 23 (2015): 815. http://dx.doi.org/10.1182/blood.v126.23.815.815.

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Abstract Introduction: Early ASCT improves progression-free survival (PFS) but not overall survival (OS) in poor prognosis DLBCL treated with R-CHOP immuno-chemotherapy (Stiff P et al., NEJM 2013). Furthermore, indiscriminate ASCT exposes those poor-risk patients destined to remain in CR with R-CHOP alone to unnecessary toxicity. Here, the role of interim PET/CT to risk-stratify is controversial. One confounding factor is that interim PET/CT is typically performed after 2 (or 3) cycles of chemotherapy when FDG-avidity likely reflects a mix of residual cancer cells and inflammation; in contrast

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Owie, Anggra Agastyassa, and Wahyu Utami Wati. "Optimalisasi Pelatihan Penyutradaraan untuk Meningkatkan Keterampilan dan Memperluas Peluang Masuk Dunia Kerja pada Anggota Teach4Hope di KitaBisa.com." Welfare : Jurnal Pengabdian Masyarakat 1, no. 4 (2023): 692–97. https://doi.org/10.30762/welfare.v1i4.998.

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This community service activity aims to improve skills and provide opportunities for orphans, poor people, and people with disabilities in the world of film through director training. The method involves the active participation of participants in the preparation, implementation, and evaluation stages. The training was held on July 7-8, 2023, at the Yogyakarta Film Academy with a focus on understanding directors, including screenplay scripts, locations, characterization, timing, and director responsibilities. A total of 15 participants produced a film entitled "Ulat Becomes a Butterfly," which

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Pal, Jagannath, Jeffrey Sawyer, Samir B. Amin, et al. "Elevated Homologous Recombination Induces Karyotypic Changes and Predicts Poor Clinical Outcome In Multiple Myeloma." Blood 116, no. 21 (2010): 1924. http://dx.doi.org/10.1182/blood.v116.21.1924.1924.

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Abstract Abstract 1924 Homologous recombination (HR), by inducing DNA rearrangements, plays an important role in cancer cell proliferation and progression via induction of oncogene activation, and/or anti-oncogene inactivation (or loss of heterozygosity at tumor suppressor loci), as well as telomere-expansion. We have observed that recombinase (RAD51) expression and homologous recombination (HR) activity are constitutively elevated in multiple myeloma (MM) as well as other cancers, and the suppression of recombinase (hsRAD51) reduces HR and significantly inhibits genomic instability and develo

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Ball, Brian J., Christopher Famulare, Eytan M. Stein, et al. "Combined Venetoclax and Hypomethylating Agent (HMA) Therapy Induces High Response Rates in Patients with Myelodysplastic Syndrome Including Patients Previously Failing HMA." Blood 134, Supplement_1 (2019): 4241. http://dx.doi.org/10.1182/blood-2019-125113.

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Background Hypomethylating agents (HMAs) are the current standard of care therapy in high-risk MDS. However, only ~50% of patients with MDS respond to HMAs and most responding patients eventually progress. Outcomes after HMA failure in patients with high-risk MDS are especially poor, with median survival of 4 to 6 months. Venetoclax in combination with HMAs led to deep and durable remissions in elderly patients with newly diagnosed AML with CR+CRi rate of 67% and median survival of 17.5 months.Here, we performed a multicenter retrospective analysis to determine outcomes in patients with MDS re

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