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Journal articles on the topic 'Disabling chronic illness'

Author: Grafiati

Published: 25 January 2025

Last updated: 31 July 2025

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1

Strickland, Bonnie R. "Sex-Related Differences in Health and Illness." Psychology of Women Quarterly 12, no. 4 (1988): 381–99. http://dx.doi.org/10.1111/j.1471-6402.1988.tb00972.x.

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Mortality and morbidity statistics which reflect the major health disorders in the nation have changed dramatically in this century. Infectious diseases have been largely controlled, and this country's citizens are now burdened with the chronic and disabling disorders of an aging population that are increasingly linked to environmental and behavioral factors. This article documents gender and sex differences among the major life-threatening disorders and chronic health problems and suggests implications for psychology as a health science and profession.

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Divo, Miguel J., Carlos H. Martinez, and David M. Mannino. "Ageing and the epidemiology of multimorbidity." European Respiratory Journal 44, no. 4 (2014): 1055–68. http://dx.doi.org/10.1183/09031936.00059814.

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The world’s population is ageing and an important part of this demographic shift is the development of chronic illness. In short, a person who does not die of acute illnesses, such as infections, and survives with chronic illnesses is more likely to develop additional chronic illnesses. Chronic respiratory diseases are an important component of these diseases associated with ageing. This article reviews the relationship between ageing and chronic respiratory disease, and also how certain chronic diseases cluster with others, either on the basis of underlying risk factors, complication of the p

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Sharpe, Michael, and Monica Greco. "Chronic fatigue syndrome and an illness-focused approach to care: controversy, morality and paradox." Medical Humanities 45, no. 2 (2019): 183–87. http://dx.doi.org/10.1136/medhum-2018-011598.

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Contemporary medicine distinguishes between illness and disease. Illness refers to a person’s subjective experience of symptoms; disease refers to objective bodily pathology. For many illnesses, medicine has made great progress in finding and treating associated disease. However, not all illnesses are successfully relieved by treating the disease. In some such cases, the patient’s suffering can only be reduced by treatment that is focused on the illness itself. Chronic disabling fatigue is a common symptom of illness, for which disease-focused treatment is often not effective, but for which il

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Insel, Thomas R., Michael Schoenbaum, and Philip S. Wang. "Components of the Economic Burden of Serious Mental Illness in the US." US Neurology 05, no. 01 (2009): 10. http://dx.doi.org/10.17925/usn.2009.05.01.10.

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Mental disorders impose considerable socioeconomic costs due to their episodic/chronic nature, their relatively early ages at onset, and the highly disabling nature of inadequately treated mental illness. Despite substantial increases in the volume of mental health treatment for disorders in the past two decades, particularly pharmacotherapies, the level of morbidity and mortality from these disorders does not appear to have changed substantially over this period. Improving outcomes will require the development and use of more efficacious treatments for mental disorders. Likewise, implementati

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Karaboue, Karidia. "Headaches: A Gendered Illness." International Journal of Multidisciplinary Comprehensive Research 2, no. 6 (2023): 65–67. http://dx.doi.org/10.54660/ijmcr.2023.2.6.65-67.

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Headaches are not a symptom but a neurological disorder which mainly affects females and is the human race’s third most frequent and second most disabling illness, according to the World Health Organisation (WHO). Headaches are the epitome of chronic pain in females during their peak years of life. Those who are prone to this disorder suffer not only physically during an acute headache attack with its resulting incapacitating effects but also because of the anguish associated with the onset of new attacks. Its lack of 'social' recognition as a genuine, severe and incapacitating pathology is a

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Neki, NS. "Chronic fatigue syndrome revisited." Bangladesh Journal of Medical Science 15, no. 3 (2016): 326–28. http://dx.doi.org/10.3329/bjms.v15i3.30126.

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Chronic fatigue syndrome (CFS) is a common and disabling problem; although most likely of biopsychosocial origin. The nature of the pathophysiological components remains unclear. It is an illness characterized by persistent and relapsing fatigue, often accompanied by numerous symptoms involving various body systems. The etiology of CFS remains unclear. Celiac disease can present with neurological symptoms in the absence of gastrointestinal symptoms; therefore, celiac disease should be included in the differential diagnosis of CFS.Bangladesh Journal of Medical Science Vol.15(3) 2016 p.326-328

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Ward, MC, and P. Higgs. "Psychosocial aspects of adjusting to disability in older people." Reviews in Clinical Gerontology 8, no. 3 (1998): 251–56. http://dx.doi.org/10.1017/s0959259898008375.

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Studies across the European Union have noted that chronic illness and chronic disabling conditions rather than acute infectious diseases are now the major causes of morbidity and mortality in member states. This transformation in the nature of health and illness has, and will continue to have, profound effects on the nature of both medicine and the policy and organization of health care. It is estimated that not only will the share of consultations with doctors about issues connected with problems of living with chronic conditions increase, but there will also be a corresponding shift in medic

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Awang, Halimah, Norma Mansor, Tey Nai Peng, and Nik Ainoon Nik Osman. "Understanding ageing: fear of chronic diseases later in life." Journal of International Medical Research 46, no. 1 (2017): 175–84. http://dx.doi.org/10.1177/0300060517710857.

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Objectives Ageing is often associated with deteriorating mental and physical health and the need for long-term care, creating a fear of ageing. We investigated what people fear most in terms of disabling chronic diseases and their concerns regarding having long-term illnesses. Methods Data were obtained from an online survey of 518 respondents aged 40 years and older residing in Malaysia, which was based on a convenience sample collected in May 2015 to January 2016. Data were analyzed using chi-squared tests and multinomial logistic regression. Results Of the most dreaded diseases, heart disea

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Sreedhar, Sreelakshmi, Aswini B, Neethu Poulose, Akhil Hari, and P. N. Sureshkumar. "The quality of life assessment of chronic schizophrenia and diabetic patients with WHO-QOL in Indian population: a comparative study." Research in Pharmacy and Health Sciences 4, no. 2 (2018): 442–47. http://dx.doi.org/10.32463/rphs.2018.v04i02.07.

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Background: Schizophrenia is a chronic, severe and disabling psychiatric disorder and diabetes mellitus is one of the most prevalent non-psychiatric chronic illnesses. Both the diseases have common features of their chronicity, economic burden and dysfunction of occupation. QOL becomes more important health outcome tool in disorders that are chronic or where treatment continues over a long period. Methodology: In this study, descriptive survey was used to collect the data. Demographics details, laboratory results, given drugs, medical and medication history were documented into the data entry

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Rakhkovskaya, Liya M., and Jason M. Holland. "Body dissatisfaction in older adults with a disabling health condition." Journal of Health Psychology 22, no. 2 (2016): 248–54. http://dx.doi.org/10.1177/1359105315600237.

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Existing findings on body dissatisfaction in older adults are sparse. In addition, research suggests that chronic illness may elevate risk for body dissatisfaction. Accordingly, this study examined predictors of body dissatisfaction in 274 older adults with a disabling health condition. Most participants reported dissatisfaction with their weight, shape, and/or appearance. Higher body mass index and negative impact of health on appearance predicted body dissatisfaction. Gender comparisons revealed that depressed mood may fuel body dissatisfaction in women. Somatic symptoms predicted body dissa

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Whitney, Jenna, Joanna Murray, Kay Gavan, Gill Todd, Wendy Whitaker, and Janet Treasure. "Experience of caring for someone with anorexia nervosa: qualitative study." British Journal of Psychiatry 187, no. 5 (2005): 444–49. http://dx.doi.org/10.1192/bjp.187.5.444.

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BackgroundCaring for someone with anorexia nervosa is distressing.AimsTo gain a detailed understanding of carers' illness models and caregiving experiences.MethodQualitative analysis and computerised text analysis were conducted on narratives written by parents as part of a family intervention at a specialist in-patient unit (20 mothers, 20 fathers)ResultsThemes concerned illness perceptions, impact on the family and carers' emotional, cognitive and behavioural responses towards the illness. Parents perceived anorexia nervosa to be chronic and disabling. Carers blamed themselves as contributin

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Vallis, T. Michael, and Geoffrey K. Turnbull. "Clinical Management of Inflammatory Bowel Disease: Beyond Disease Activity. I. Assessing Psychosocial Factors." Canadian Journal of Gastroenterology 6, no. 1 (1992): 39–43. http://dx.doi.org/10.1155/1992/187197.

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Inflammatory bowel disease (IBD) is a chronic, relapsing disorder that can be very disabling to the patient and often leads to significant lifestyle problems (eg, emotional distress, social isolation, work impairment and disability). Available evidence strongly indicates that health status is influenced by psychosocial factors as well as disease activity. This is the first of a two-part series, the purpose of which is to provide a framework to guide the gastroenterologist in the assessment and management of psychosocial factors that impact on the health status of the IBD patient. Part I contai

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Gignac, Monique A. M., Cheryl A. Cott, and Elizabeth M. Badley. "Living with a Chronic Disabling Illness and Then Some: Data from the 1998 Ice Storm." Canadian Journal on Aging / La Revue canadienne du vieillissement 22, no. 3 (2003): 249–59. http://dx.doi.org/10.1017/s0714980800003871.

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ABSTRACTThis study examined the impact of the 1998 Canadian ice storm on the physical and psychological health of older adults (age > 55 years) living with a chronic physical illness, namely osteoarthritis and/or osteoporosis. Although disasters are relatively rare, they are a useful means of examining the impact of a single stressor on a group of individuals. Specifically, we took advantage of a natural experiment to compare the responses of a group of 59 ice storm victims to those of 55 matched controls living outside the ice storm area. Data on disability, pain, self-reported health, hel

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Allen, Shelley, and Glenys Carlson. "To conceal or disclose a disabling condition? A dilemma of employment transition." Journal of Vocational Rehabilitation 19, no. 1 (2003): 19–30. http://dx.doi.org/10.3233/jvr-2003-00199.

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Disclosure is recognised as an issue for people of working age with a mental illness. Disclosure may also be an issue for people of working age with physical disabilities and chronic illness who are endeavouring to obtain and retain employment within their diminished work capacity in the open labour market. This paper is based on qualitative research into the employment transition of 13 participants with a range of disabling conditions. The conditions included rheumatoid arthritis, osteoarthritis, cancer, depression, HIV/AIDS, fracture of the wrist, traumatic head injury, and intervertebral lu

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H, Nafiaa, Benchikhi L, and Ouanass A. "Morphological Abnormalities in Schizophrenia: Systematic Review." SAS Journal of Medicine 8, no. 4 (2022): 376–83. http://dx.doi.org/10.36347/sasjm.2022.v08i05.005.

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Schizophrenia is a severe, frequent, heterogeneous, longlasting and disabling chronic mental illness with high social impact, belonging to the group of chronic psychoses. There are several clinical forms and several possible evolutionary modes. Its etiopathogenesis is multifactorial (hereditary, biological, environmental, etc.) but no single cause has been demonstrated up till now. Schizophrenia is a group of disabling heterogeneous disorders that are generally severe, the course of which is chronic and disabling, and the prognosis is poor. Many retrospective studies have attempted to trace th

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Ossa, Luisa Marcela. "Inextricably Tied: Gender, Race, Chronic Illness, and Disability in the Works of Edelma Zapata Pérez." Journal of Gender and Sexuality Studies / Revista de Estudios de Género y Sexualidades 45, no. 1 (2019): 205–20. http://dx.doi.org/10.14321/jgendsexustud.45.1.0205.

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Abstract This article examines the works of Colombian author Edelma Zapata Pérez as disability life writing, that is, literature that gives the disabled author agency (Couser). Since Zapata Pérez was multi-ethnic and disabled, Crenshaw’s theory of intersectionality is utilized to demonstrate that these identities are intertwined in her life and writings. Subsequently, Zapata Pérez’s representations of disability are examined via Siebers’s idea of complex embodiment, which “raises awareness of the effects of disabling environments on people’s lived experience of the body, but it emphasizes as w

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Lynch, Cameron, C. D'Arcy J. Holman, and Rachael E. Moorin. "Use of Western Australian linked hospital morbidity and mortality data to explore theories of compression, expansion and dynamic equilibrium." Australian Health Review 31, no. 4 (2007): 571. http://dx.doi.org/10.1071/ah070571.

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Three hypotheses have been advanced to predict changes in population health in countries experiencing low birth and death rates, and increasing expectation of life. Determining which of these best accounts for changing patterns of illness and death is an important step in understanding both the public health and economic impacts of health interventions in an ageing population. The aim of this study was to use the WA Data Linkage System to evaluate the compression, expansion and dynamic equilibrium theories in Western Australia. Changes in life expectancy, average age at first-time hospitalisat

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Goudsmit, Ellen, Charles Shepherd, Christine P. Dancey, and Sandra Howes. "ME: Chronic fatigue syndrome or a distinct clinical entity?" Health Psychology Update 18, no. 1 (2009): 26–33. http://dx.doi.org/10.53841/bpshpu.2009.18.1.26.

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Myalgic encephalomyelitis (ME) is a disabling condition characterised by profound fatigue following minimal exertion and a delay in recovery after exertion ends. In 1988, when specialists introduced the concept of chronic fatigue syndrome (CFS), it was assumed that the illness in question was identical to ME but the lack of research criteria for the latter has prevented the testing of this assumption.In this article, we propose criteria and guidelines which can be used to study ME and determine whether it is a synonym for CFS or one of several subgroups contained within the CFS construct. If c

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Cipolletta, Sabrina, Silvia Caterina Maria Tomaino, Eliana Lo Magno, and Elena Faccio. "Illness Experiences and Attitudes towards Medication in Online Communities for People with Fibromyalgia." International Journal of Environmental Research and Public Health 17, no. 22 (2020): 8683. http://dx.doi.org/10.3390/ijerph17228683.

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Fibromyalgia is a chronic disabling syndrome, and the legitimacy of its diagnosis is still debated. Internet and online communities may become a relevant resource for affected people. This present study aims to understand the role of online communities relating to fibromyalgia syndrome (FMS) patients’ illness experiences and their attitudes towards medication. A qualitative content analysis based on the grounded theory approach was conducted on 19 conversations from an online forum, and 14 online interviews. Illness experience, lack of reference points, online communities, personal role and at

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Cheshire, Anna, Damien Ridge, Lucy V. Clark, and Peter D. White. "Sick of the Sick Role: Narratives of What “Recovery” Means to People With CFS/ME." Qualitative Health Research 31, no. 2 (2020): 298–308. http://dx.doi.org/10.1177/1049732320969395.

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Little is known about what recovery means to those with chronic fatigue syndrome/myalgic encephalomyelitis, a poorly understood, disabling chronic health condition. To explore this issue, semi-structured interviews were conducted with patients reporting improvement ( n = 9) and deterioration ( n = 10) after a guided self-help intervention, and analyzed via “constant comparison.” The meaning of recovery differed between participants—expectations for improvement and deployment of the sick role (and associated stigma) were key influences. While some saw recovery as complete freedom from symptoms,

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Boiko, E. A., V. L. Malygin, and E. I. Glushchenko. "Characteristics of the parent-child relationship in families of children with cerebral palsy and multiple sclerosis (literature review)." Neurology, Neuropsychiatry, Psychosomatics 16, no. 6 (2024): 83–88. https://doi.org/10.14412/2074-2711-2024-6-83-88.

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Multiple sclerosis (MS) and cerebral palsy (CP) are chronic disabling diseases caused by central nervous system affection. The diagnosis of a chronic illness in a child is a psychotraumatic event that disrupts the structure and functioning of the family system, the psychological well-being and the health of family members. In the process of adapting to the stress factor, both parent-child relationships and marital relationships are deformed. In most families raising disabled children, disharmonious parenting styles prevail. Parents report a decrease in quality of life, dissatisfaction with the

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Webb, Rhona, Julie T. Mangrobang, Alison Conning, and Martin W. Orrell. "A Social Therapy for Long-term Mentally III Inpatients: A Pilot Study." Behavioural Psychotherapy 21, no. 1 (1993): 57–62. http://dx.doi.org/10.1017/s014134730001781x.

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Long-term inpatients with severe psychiatric illness such as chronic schizophrenia can be very socially disabled. This makes it difficult for them to move on to more independent living because they lack many of the necessary social and practical skills. Social Economy Therapy (SET) is a practical approach which aims to improve social functioning. On a hostel ward, eight long term inpatients with severe and disabling psychiatric disorders started a SET programme. After two months the social and living skills of several patients were improved and a number were discharged to other accommodation.

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Kimpson, Sally A. "Uncertain Subjects: Shaping Disabled Women’s Lives Through Income Support Policy." Canadian Journal of Disability Studies 9, no. 3 (2020): 78–103. http://dx.doi.org/10.15353/cjds.v9i3.647.

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   This article provides a critical reading of one aspect of the “third mobilization of transinstitutionalization” (Haley & Jones, 2018), focused on how power is exercised through the B.C. government income support program (or the ambiguously-named B.C. Benefits), shaping the embodied lives of women living with chronic physical and mental impairments. I research and write as a woman living with a disabling chronic illness whose explicit focus is power: how it is enacted and what it produces in the everyday lives of women with disabling chronic conditions living on income

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Amaral, J., Peter Taylor, Mauro Teixeira, Thomas Morrison, and Robert Schoen. "The Clinical Features, Pathogenesis and Methotrexate Therapy of Chronic Chikungunya Arthritis." Viruses 11, no. 3 (2019): 289. http://dx.doi.org/10.3390/v11030289.

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Chikungunya fever (CHIKF) is an emerging viral infection that has spread widely, along with its Aedes vectors, throughout the tropics and beyond, causing explosive epidemics of acute illness and persistent disabling arthritis. The rheumatic symptoms associated with chikungunya virus (CHIKV) infection include polyarthralgia, polyarthritis, morning stiffness, joint edema, and erythema. Chronic CHIK arthritis (CCA) often causes severe pain and associated disability. The pathogenesis of CCA is not well understood. Proposed hypotheses include the persistence of a low level of replicating virus in t

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Lim, Eun-Jin, and Chang-Gue Son. "Prevalence of Chronic Fatigue Syndrome (CFS) in Korea and Japan: A Meta-Analysis." Journal of Clinical Medicine 10, no. 15 (2021): 3204. http://dx.doi.org/10.3390/jcm10153204.

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Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a long-term disabling illness accompanied by fatigue unsolved by rest. However, ME/CFS is a poorly understood illness that lacks a universally accepted pathophysiology and treatment. A lack of CFS-related studies have been conducted in Asian countries. This study aimed to estimate and compare the prevalence of ME/CFS in Korea and Japan and conducted a meta-analysis. Methods: We searched PubMed, EMBASE, Cochrane, and KMBASE for population-based prevalence studies of the two countries and synthesized the data according to

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Stein, E., and M. MacQuarrie. "Workshop/conference report - Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) program and Interdisciplinary Research Symposium on Disabling Fatigue in Chronic Illness." Chronic Diseases in Canada 29, no. 3 (2009): 136–39. http://dx.doi.org/10.24095/hpcdp.29.3.06.

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Gupta, G., and S. Nagendran. "Comparative study of caregiver stress between patients of obsessive compulsive disorder and chronic medical illness, without any physical disability." European Psychiatry 64, S1 (2021): S742—S743. http://dx.doi.org/10.1192/j.eurpsy.2021.1967.

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IntroductionObsessive compulsive disorder (OCD) is a disabling condition that affects the quality of life of both the patient and the caregivers. Similarly, in patients with physical medical illness, caregivers face a significant amount of stress.ObjectivesThis study aimed to assess and compare the caregiver strain index between patients of OCD and medical illness. Moreover, this study will also compare the care giver strain index in the patients of OCD and physical medical illness depending on the severity and duration of the illness.MethodsStudy was done at Department of psychiatry, Teerthan

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Jahanshahi, M., and C. D. Marsden. "Personality in torticollis: a controlled study." Psychological Medicine 18, no. 2 (1988): 375–87. http://dx.doi.org/10.1017/s0033291700007923.

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SynopsisThe Eysenck Personality Questionnaire, the trait scales of the Leyton Obsessional Inventory, the Spielberger State Trait Anxiety Inventory, and a questionnaire assessing marital status and harmony were completed by 100 torticollis patients and a control group of 49 cervical spondylosis sufferers. Information regarding employment status, and events preceding onset of their complaint was also obtained. The two groups did not differ in terms of any of the personality dimensions evaluated, or in their self-reports of events prior to onset of their illness. The groups differed significantly

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Heij, Lara, Albert Dahan, and Elske Hoitsma. "Sarcoidosis and Pain Caused by Small-Fiber Neuropathy." Pain Research and Treatment 2012 (December 5, 2012): 1–6. http://dx.doi.org/10.1155/2012/256024.

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Sarcoidosis is a chronic inflammatory illness and small-fiber neuropathy (SFN) is one of the disabling and often chronic manifestations of the disease. SFN presents with peripheral pain and symptoms of autonomic dysfunction. The character of the pain can be burning or shooting. Besides, allodynia and hyperesthesia can exist. Diagnosis is usually made on the basis of clinical features, in combination with abnormal specialized tests. The aim of treatment is often to reduce pain; however, total pain relieve is seldom achieved. The role of TNF-α in the pathogenesis of SFN in sarcoidosis appears in

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DAHESHIA, MASSOUD, та JIAN Q. YAO. "The Interleukin 1β Pathway in the Pathogenesis of Osteoarthritis". Journal of Rheumatology 35, № 12 (2008): 2306–12. http://dx.doi.org/10.3899/jrheum.080346.

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Osteoarthritis (OA) is a major disabling disease and is ranked as a major cause of chronic pain in adults. The pathology of the illness is characterized by a loss of articular cartilage leading to narrowing of joint space, increased joint friction, potential structural remodeling, persistent pain, and functional impairment. The proinflammatory cytokine interleukin 1β (IL-1β) has several chemical and bioactive characteristics allowing this catabolic protein to be involved in initiation and progression of OA. We review the current understanding of the pathogenesis of OA, and how upregulation of

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Carmassi, Claudia, Valerio Dell’Oste, Claudia Foghi, et al. "Post-Traumatic Stress Reactions in Caregivers of Children and Adolescents/Young Adults with Severe Diseases: A Systematic Review of Risk and Protective Factors." International Journal of Environmental Research and Public Health 18, no. 1 (2020): 189. http://dx.doi.org/10.3390/ijerph18010189.

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Severe illnesses in children and adolescents/young adults (AYAs) may represent a complex burden for patients and their caregivers, including a wide range of mental disorders, particularly post-traumatic stress disorder (PTSD). Few events are as potentially traumatizing as having a son or a daughter diagnosed with a severe, life-threatening, or disabling disease. The presence of PTSD symptoms in caregivers may compromise their efficacy as caregivers and negatively affect the child’s well-being. This systematic review aims at outlining potential risk and protective factors for the development of

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Waynforth, David. "Life-history theory, chronic childhood illness and the timing of first reproduction in a British birth cohort." Proceedings of the Royal Society B: Biological Sciences 279, no. 1740 (2012): 2998–3002. http://dx.doi.org/10.1098/rspb.2012.0220.

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Life-history theoretical models show that a typical evolutionarily optimal response of a juvenile organism to high mortality risk is to reach reproductive maturity earlier. Experimental studies in a range of species suggest the existence of adaptive flexibility in reproductive scheduling to maximize fitness just as life-history theory predicts. In humans, supportive evidence has come from studies comparing neighbourhoods with different mortality rates, historical and cross-cultural data. Here, the prediction is tested in a novel way in a large ( n = 9099), longitudinal sample using data compar

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Martinez Villegas, Hector Xavier, Alejandro Hallo, Soraya Cruz-Loor, and Karen Jacome-Calderon. "Spinal cord stimulator for neuropathic pain in a patient with severe disability due to transverse myelitis." BMJ Case Reports 14, no. 5 (2021): e242522. http://dx.doi.org/10.1136/bcr-2021-242522.

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Transverse myelitis is an inflammatory disease of the central nervous system that disrupts nerve signals’ conduction. The illness is characterised by weakness in the lower limbs accompanied by paresthesia and urinary and bowel incontinence. The most disabling sequel is the onset of chronic neuropathic pain, which can severely limit the patient’s independence and negatively affect her quality of life. We present the case of a patient who received a spinal neurostimulator after a failure of conventional medical treatment. Masking pain through paresthesia, a mechanism provided by the device signi

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Park, Hyun-Sun, Jongmin Kim, Seong Hoon Ahn, and Hong-Yeoul Ryu. "Epigenetic Targeting of Histone Deacetylases in Diagnostics and Treatment of Depression." International Journal of Molecular Sciences 22, no. 10 (2021): 5398. http://dx.doi.org/10.3390/ijms22105398.

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Depression is a highly prevalent, disabling, and often chronic illness that places substantial burdens on patients, families, healthcare systems, and the economy. A substantial minority of patients are unresponsive to current therapies, so there is an urgent need to develop more broadly effective, accessible, and tolerable therapies. Pharmacological regulation of histone acetylation level has been investigated as one potential clinical strategy. Histone acetylation status is considered a potential diagnostic biomarker for depression, while inhibitors of histone deacetylases (HDACs) have garner

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Mark, Victor W., and Edward Taub. "Constraint-induced movement therapy for chronic stroke hemiparesis and other disabilities." Restorative Neurology and Neuroscience 22, no. 3-5 (2004): 317–36. https://doi.org/10.3233/rnn-2004-00264.

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Constraint-Induced Movement Therapy (CI therapy) refers to a family of treatments for motor disability that combines constraint of movement, massed practice, and shaping of behavior to improve the amount of use of the targeted limb. CI therapy has controlled evidence for efficacy that supports its benefit for patients with chronic disability following central nervous system injury, regardless of their age or the interval since illness onset. Furthermore, the benefits transfer to real-world measures of limb use. Significant functional improvement may occur even after the patient has been treate

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Keightley, Philip, Rebecca E. Reay, Paul Pavli, and Jeffrey CL Looi. "Inflammatory bowel disease-related fatigue is correlated with depression and gender." Australasian Psychiatry 26, no. 5 (2018): 508–13. http://dx.doi.org/10.1177/1039856218772245.

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Objectives: Fatigue is a common and disabling problem in inflammatory bowel disease. We sought to explore the possible determinants of inflammatory bowel disease-associated fatigue including demographic, psychological and disease variables. Methods: Surveys were distributed to 100 patients undergoing infliximab infusion for inflammatory bowel disease in an infusion lounge, assessing attachment style (Experiences in Close Relationships Revised scale), fatigue (Functional Assessment of Chronic Illness Therapy Fatigue – Fatigue Subscore), and depression and anxiety (Hospital Anxiety and Depressio

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Carolle Laure MATENE FONGANG. "Disability and sexuality: The sexual life of the person living with a disability, his affective life and his life as a couple." World Journal of Advanced Research and Reviews 18, no. 2 (2023): 544–63. http://dx.doi.org/10.30574/wjarr.2023.18.2.0850.

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Sexuality with a disabling disease, or serious disabling or disability: a sensitive subject probably due to the association of the two words: sexuality and disability. The question of the emotional life, the life of a couple, the sexuality of a person living with a disability remains a real social and cultural problem. This necessarily impacts on the people concerned because they are victims of their states of disability. This is a subject that is difficult to address both by the couple, by society and by health professionals. In addition, it should be noted that regardless of their physical o

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Carolle, Laure MATENE FONGANG. "Disability and sexuality: The sexual life of the person living with a disability, his affective life and his life as a couple." World Journal of Advanced Research and Reviews 18, no. 2 (2023): 544–63. https://doi.org/10.5281/zenodo.8405016.

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Sexuality with a disabling disease, or serious disabling or disability: a sensitive subject probably due to the association of the two words: sexuality and disability. The question of the emotional life, the life of a couple, the sexuality of a person living with a disability remains a real social and cultural problem. This necessarily impacts on the people concerned because they are victims of their states of disability. This is a subject that is difficult to address both by the couple, by society and by health professionals. In addition, it should be noted that regardless of their physical o

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Tosato, G., S. Straus, W. Henle, S. E. Pike, and R. M. Blaese. "Characteristic T cell dysfunction in patients with chronic active Epstein-Barr virus infection (chronic infectious mononucleosis)." Journal of Immunology 134, no. 5 (1985): 3082–88. http://dx.doi.org/10.4049/jimmunol.134.5.3082.

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Abstract We evaluated immune functions in 16 patients with chronic active Epstein-Barr virus (EBV) infection (chronic infectious mononucleosis). Chronic infectious mononucleosis is an illness characterized primarily by chronic and occasionally disabling fatigue and other constitutional complaints, only sometimes beginning with an episode of acute infectious mononucleosis, and associated with an abnormal pattern of serum antibodies to EBV. In these patients, the frequency of circulating EBV-infected B cells that manifested spontaneous outgrowth in vitro was comparable to that found in EBV-serop

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Powell, Pauline, Richard H. T. Edwards, and Richard P. Bentall. "THE TREATMENT OF WHEELCHAIR-BOUND CHRONIC FATIGUE SYNDROME PATIENTS: TWO CASE STUDIES OF A PRAGMATIC REHABILITATION APPROACH." Behavioural and Cognitive Psychotherapy 27, no. 3 (1999): 249–60. http://dx.doi.org/10.1017/s1352465899273067.

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Chronic fatigue syndrome is a disabling condition characterized by persistent mental and physical fatigue. Its aetiology is controversial, and it has been attributed to both physical and psychological causes. Previous controlled trials with ambulatory patients have shown that a proportion of CFS patients respond to cognitive-behaviour therapy. In this paper, we report two case studies of patients who are wheelchair-bound, who have been treated by a pragmatic intervention designed to increase activity and challenge dysfunctional illness beliefs. The patients received 60 and 55 contacts with the

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Buchwald, Dedra, Richard Herrell, Suzanne Ashton, Megan Belcourt, Karen Schmaling, and Jack Goldberg. "The Chronic Fatigue Twin Registry: method of construction, composition, and zygosity assignment." Twin Research 2, no. 3 (1999): 203–11. http://dx.doi.org/10.1375/twin.2.3.203.

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AbstractChronic fatigue syndrome (CFS) and the symptom of chronic fatigue are conditions of unknown etiology. The Centers for Disease Control and Prevention (CDC) define CFS as an illness characterized by ≥ 6 months of disabling fatigue associated with muscle pain, pharyngitis, and alterations in mood, sleep and neurocognition. We constructed a registry of twins with chronic fatigue to facilitate research on the impact of illness, the associated medical and psychosocial factors, and the heterogeneous proposed mechanisms for these conditions. We have recruited 204 twin pairs in which one or bot

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Binford, Sasha S., Erin M. Hubbard, Elena Flowers, Bruce L. Miller, and Heather Leutwyler. "Serum BDNF Is Positively Associated With Negative Symptoms in Older Adults With Schizophrenia." Biological Research For Nursing 20, no. 1 (2017): 63–69. http://dx.doi.org/10.1177/1099800417735634.

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Objectives: Older adults with chronic schizophrenia are at greater risk for functional disability and poorer health outcomes than those without serious mental illness. These individuals comprise 1–2% of the elderly population in the United States and are projected to number approximately 15 million by 2030. The symptoms of schizophrenia can be disabling for individuals, significantly reducing quality of life. Often, the negative symptoms (NS) are the most resistant to treatment and are considered a marker of illness severity, though they are challenging to measure objectively. Biomarkers can s

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Kalimuddin, Shirin, Yii Ean Teh, Liang En Wee, et al. "Chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness." PLOS Neglected Tropical Diseases 16, no. 8 (2022): e0010724. http://dx.doi.org/10.1371/journal.pntd.0010724.

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Long Covid has raised awareness of the potentially disabling chronic sequelae that afflicts patients after acute viral infection. Similar syndromes of post-infectious sequelae have also been observed after other viral infections such as dengue, but their true prevalence and functional impact remain poorly defined. We prospectively enrolled 209 patients with acute dengue (n = 48; one with severe dengue) and other acute viral respiratory infections (ARI) (n = 161), and followed them up for chronic sequelae up to one year post-enrolment, prior to the onset of the Covid-19 pandemic. Baseline demog

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Cavanaugh, Courtenay E., Jill T. Messing, Evelina Eyzerovich, and Jacquelyn C. Campbell. "Ethnic Differences in Correlates of Suicidal Behavior Among Women Seeking Help for Intimate Partner Violence." Crisis 36, no. 4 (2015): 257–66. http://dx.doi.org/10.1027/0227-5910/a000321.

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Abstract. Background: Women abused by an intimate partner are at risk of engaging in nonfatal suicidal behavior and suicidal communication (NSBSC). No studies have examined ethnic differences in correlates of NSBSC among abused women. Aims: This secondary data analytic study examined whether correlates of NSBSC previously reported among a mixed ethnic sample of women seeking help for abuse by a male intimate partner differed for those who self-identified as Latina (N = 340), African American (N = 184), or European American (N = 67). Method: Logistic regression was used to examine correlates of

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Keating, Julie A., Catherine Shaughnessy, Kelsey Baubie, et al. "Characterising the gut microbiome in veterans with Gulf War Illness: a protocol for a longitudinal, prospective cohort study." BMJ Open 9, no. 8 (2019): e031114. http://dx.doi.org/10.1136/bmjopen-2019-031114.

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IntroductionApproximately 25%–35% of the 1991 Gulf War Veteran population report symptoms consistent with Gulf War Illness (GWI), a chronic, multi-symptom illness characterised by fatigue, pain, irritable bowel syndrome and problems with cognitive function. GWI is a disabling problem for Gulf War Veterans, and there remains a critical need to identify innovative, novel therapies.Gut microbiota perturbation plays a key role in the symptomatology of other chronic multi-symptom illnesses, including myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Given similarities between ME/CFS and

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Ballyout, H., F. Simou, A. H. Amdaoui, et al. "Hypothyroidism and Schizophrenia: Causal Link and Therapeutic Challenge – A Case Report." SAS Journal of Medicine 11, no. 05 (2025): 564–66. https://doi.org/10.36347/sasjm.2025.v11i05.033.

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Schizophrenia is a chronic disabling psychosis characterized by thought disorganization, positive symptoms such as hallucinations and delusions, and negative symptoms including apathy and social withdrawal. Among the many pathophysiological hypotheses proposed, endocrine disturbances—particularly thyroid dysfunction—have attracted increasing attention. We report the case of a 28-year-old man with schizophrenia in whom a severe hypothyroidism was diagnosed during the course of illness. This case highlights important clinical considerations regarding the interaction between these two conditions

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Akhyar, Gardenia, Irdawaty Izrul, and Adianto Jaya Nagara. "Mucous Membrane Pemphigoid: A Frustrating Disabling Disease in A 15-year-old Male." Journal La Medihealtico 5, no. 1 (2024): 204–9. http://dx.doi.org/10.37899/journallamedihealtico.v5i1.1078.

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Mucous membrane pemphigoid (MMP) is a rare chronic autoimmune subepithelial blistering disease characterized by erosive lesions of mucous membranes and skin that typically results in scarring of at least some sites of involvement. A progressive disorder that may result in serious complications including blindness, loss of the airway, and esophageal stricture formation. Most patient experience reduced quality of life specifically with ocular symblepharon and laryngeal destruction. Case: We present a case of a 15-year-old male patient with 1 month-history of multiple tense bullae, difficulty to

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Shaban, Shaista, Mohd Abrar Ahmad Guroo, and Racheal Bashir. "Study of the difference in quality of life and caregiver burden among patients with schizophrenia and rheumatoid arthritis." International Journal of Research in Medical Sciences 9, no. 6 (2021): 1577. http://dx.doi.org/10.18203/2320-6012.ijrms20211920.

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Background: Quality of life (QOL) is a measure to see an individual’s adaptation and feeling of wellbeing and adjustment with the surroundings. Schizophrenia and rheumatoid arthritis (RA) both are chronic and disabling disorders supposed to have significant effect on quality of life. Also chronicity and disability of these disorders can be directly proportional to the caregiver burden.Methods: Comparative study assessing quality of life and caregiver burden between persons with schizophrenia and RA.Results: 50% of the schizophrenia group as well as the RA group were unemployed, suggesting the

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Shmuely, Yochi, Mona Baumgarten, Barry Rovner, and Jesse Berlin. "Predictors of Improvement in Health-Related Quality of Life Among Elderly Patients With Depression." International Psychogeriatrics 13, no. 1 (2001): 63–73. http://dx.doi.org/10.1017/s1041610201007463.

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Background: Depression is the most prevalent disabling psychiatric syndrome of aging and may lead to important decrements in the elderly depressed patient's health-related quality of life (HRQL). The goal of this study was to determine whether severity of chronic illness at admission, severity of depressive symptoms at admission, or living alone before admission was associated with lack of improvement in HRQL at 3 months postdischarge among elderly depressed inpatients. Methods: Subjects were 100 consecutive patients admitted to a 26-bed inpatient geriatric psychiatry unit from 1994 through 19

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López-Hernández, Irene. "Gender perspective and determinants associated with the linkage women-informal or primary care." Mexican Journal of Medical Research ICSA 13, no. 25 (2025): 15–22. https://doi.org/10.29057/mjmr.v13i25.12428.

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The primary caregiver is a fundamental part of the health-disease process of the patient with a disabling, chronic or transitory illness. The participation of women in care is greater compared to men, this happens in various studies of informal caregivers of various diseases or disabling conditions. Feminist economics, from the perspective of care economics, points out the importance of considering the determining role of gender relations to explain the concentration of women in care activities and the minimal or less favorable participation in the work market. The objective of this narrative

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