Relevant bibliographies by topics / Discoid

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Discoid'

Author: Grafiati
Published: 5 September 2021
Last updated: 12 February 2022

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Journal articles on the topic "Discoid"

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Årøen, Asbjørn, and Brian M. Devitt. "Discoid Meniscus." Journal of Bone & Joint Surgery 95, no. 22 (November 2013): e180. http://dx.doi.org/10.2106/jbjs.m.01087.

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Neuschwander, David C. "Discoid meniscus." Operative Techniques in Orthopaedics 5, no. 1 (January 1995): 78–87. http://dx.doi.org/10.1016/s1048-6666(95)80050-6.

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Kushare, Indranil, Kevin Klingele, and Walter Samora. "Discoid Meniscus." Orthopedic Clinics of North America 46, no. 4 (October 2015): 533–40. http://dx.doi.org/10.1016/j.ocl.2015.06.007.

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William Woods, G., and Jeffery M. MD. "Discoid Meniscus." Clinics in Sports Medicine 9, no. 3 (July 1990): 695–706. http://dx.doi.org/10.1016/s0278-5919(20)30717-1.

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Atay, Ozgur Ahmet, Murat Pekmezci, Mahmut Nedim Doral, Mustafa Fevzi Sargon, Mehmet Ayvaz, and Darren L. Johnson. "Discoid Meniscus." American Journal of Sports Medicine 35, no. 3 (March 2007): 475–78. http://dx.doi.org/10.1177/0363546506294678.

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Yáñez-Acevedo, Adolfo. "Bilateral discoid lateral menisci and unilateral discoid medial menisci." Arthroscopy: The Journal of Arthroscopic & Related Surgery 17, no. 7 (September 2001): 772–75. http://dx.doi.org/10.1053/jars.2001.23585.

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Ahmed Ali, Raheel, and Scott McKay. "Familial Discoid Medial Meniscus Tear in Three Members of a Family: A Case Report and Review of Literature." Case Reports in Orthopedics 2014 (2014): 1–5. http://dx.doi.org/10.1155/2014/285675.

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Background. A discoid meniscus is a thickened variant of the normal C-shaped meniscus prone to injury. Discoid medial meniscal tears have rarely been reported within families and may suggest familial or developmental origins.Methods. We report the cases of two Caucasian brothers with symptomatic discoid medial meniscus tears. A literature review was conducted addressing discoid medial meniscus and cases of familial meniscus tears.Case Presentation. Physically active brothers presented with progressively worsening knee pain. MRI revealed medial meniscus tears in both brothers. The family history of medial meniscus tears in their mother and the discoid medial meniscus injuries found on arthroscopy suggested evidence for familial discoid medial meniscus tears.Conclusions. Discoid medial meniscus tears within a family have not been previously reported. Two cases of families with discoid lateral meniscus tears have been reported. Discoid medial meniscus is rare relative to the discoid lateral meniscus and predisposes children to symptomatic tears.
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Santoso, MD, Asep, Erwin Saspraditya, Muhammad Nagieb, Gilang Persada Aribowo, Iwan Budiwan Anwar, and Tangkas SMHS Sibarani. "SYMPTOMATIC DISCOID MENISCUS: A CASE SERIES." Hip and Knee Journal 2, no. 1 (February 20, 2021): 50–53. http://dx.doi.org/10.46355/hipknee.v2i1.63.

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Background: Discoid meniscus is a rare entity of knee pathology. The discoid meniscus can be encountered incidentally during a treatment of another knee pathology as an asymptomatic entity or can be a symptomatic pathology which warrant treatment Case presentation: There were 8 cases of symptomatic discoid meniscus reported in this retrospective case series. The symptoms presented at age range 16-47 year-old. Majority of the case (6 of 8) are lateral discoid meniscus with female gender predominant. Complete type of discoid meniscus was also found in 6 of 8 cases. There were 5 cases of ruptured discoid meniscus, three of them needed repair. Conclusions: Symptomatic discoid meniscus can be presented on wide range of age of patients. We found female gender, discoid lateral meniscus, and complete type are the predominant pattern of discoid meniscus cases presentation.
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Huntley, Arthur C. "Discoid lupus erythematosus." Journal of the American Academy of Dermatology 23, no. 3 (September 1990): 532. http://dx.doi.org/10.1016/s0190-9622(08)81126-7.

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Rebello, Gleeson, Brian E. Grottkau, Maurice B. Albright, and Dinesh Patel. "Discoid Lateral Meniscus." Techniques in Knee Surgery 5, no. 1 (March 2006): 64–69. http://dx.doi.org/10.1097/00132588-200603000-00009.

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Dissertations / Theses on the topic "Discoid"

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Meurer, Michael. "Childhood Discoid Lupus erythematosus and Antimalarials." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-135574.

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Meurer, Michael. "Childhood Discoid Lupus erythematosus and Antimalarials." Karger, 2003. https://tud.qucosa.de/id/qucosa%3A27661.

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Wahie, Shyamal. "Response to hydroxychloroquine in discoid lupus erythematosus." Thesis, University of Newcastle Upon Tyne, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.580679.

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Discoid Lupus Erythematosus (DLE) is the most common form of cutaneous lupus and causes irreversible facial scarring and disfigurement. Hydroxychloroquine is the oral therapy of choice. The factors influencing clinical response to hydroxychloroquine are unclear. Patients with Systemic Lupus Erythematosus (SLE) treated with hydroxychloroquine demonstrate a positive correlation between whole-blood hydroxychloroquine levels and clinical response. Variation in response to hydroxychloroquine might, in part, be due to genetic differences in the CYP450 genes responsible for hepatic metabolism of hydroxychloroquine between individuals, which therein could influence whole-blood hydroxychloroquine levels. The influence of genetic polymorphisms on the therapeutic response to hydroxychloroquine, in comparison with host or disease attributes such as smoking status or disease extent, is unknown. A multicentre retrospective cohort study was conducted in 200 patients with DLE treated with hydroxychloroquine. The outcomes of interest were: (i) the clinical response to hydroxychloroquine by 6 months and (ii) the effects of disease attributes, smoking, and CYP450 polymorphisms on clinical response. Although the majority of patients responded to hydroxychloroquine, a significant proportion (39%) either failed to respond or was intolerant of the drug. Cigarette smoking and CYP 206 and 2CB genotypes did not have any Significant influence on response to hydroxychloroquine. Multivariate analysis indicated that disseminated disease and concomitant SLE at baseline were both Significantly associated with lack of response to hydroxychloroquine. These findings suggest that baseline lupus severity and SLE are important predictors of response to hydroxychloroquine. A prospective study is required to further explore the response of DLE to hydroxychloroquine and to investigate the relationships between disease activity and eventual response. A validated scoring instrument was designed to specifically measure activity and damage attributable to DLE and will be essential for quantifying disease and appraising responsiveness to hydroxychloroquine in future prospective studies. Following peer review, pilot work and two reliability studies, the Score of Activity and Damage in DLE (SADDLE) was developed as a measure of disease severity in DLE. Activity is measured using erythema, induration and scaling and damage is represented by scarring and dyspigmentation. SADDLE demonstrates evidence of inter and intra-rater reliability and construct validity. In summary, these inter-related studies not only indicate that 1 in 3 patients with DLE do not respond to hydroxychloroquine by 6 months, but also show that lack of response may be associated with disease extent and concomitant SLE at baseline. Cigarette smoking did not influence response, casting doubt on the results of previous small single-site retrospective studies, which did not assess confounding variables such as disease extent and SLE and suggested smoking was associated with poor response to therapy. A disease activity score has been developed for future use in prospective trials to help investigate these findings further.
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Moure, Emanuella Rosyane Duarte. "Alopecias cicatriciais primárias: revisão de achados histopatológicos de 37 pacientes do Departamento de Dermatologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo no período de 2000 a 2005." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5133/tde-18022011-143001/.

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Introdução: As alopecias cicatriciais são subdivididas em primárias e secundárias. Nas alopecias cicatriciais primárias o folículo piloso é o alvo principal da destruição; diferentemente das secundárias onde a destruição folicular não é o evento patológico primário. Objetivo: Revisar os achados histológicos de pacientes com diagnóstico de alopecia cicatricial primária, em uma fase tardia e reclassificá-los em seus respectivos subtipos. Casuística e Métodos: Os espécimes de biópsia de pacientes com diagnóstico histológico prévio de alopecia cicatricial foram revisados e submetidos a colorações por hematoxilina e eosina (HE), ácido periódico-Schiff (PAS) e Weigert, a fim de reclassificá-los de acordo com os diferentes subtipos de alopecia. Foram utilizados para a revisão histológica critérios de infiltrado inflamatório acrescidos de coloração para fibra elástica. Resultados: Os 37 casos de alopecia cicatricial primária foram reclassificados em: lupus eritematoso discóide (16), líquen plano pilar (4), pseudopelada de Brocq (12), foliculite decalvante (3), foliculite abscedante/dessecante (1), e alopecia não-específica (1). Conclusão: Mesmo em uma fase tardia, pauci ou não inflamatória, o exame histológico, utilizando colorações de rotina, PAS e coloração para fibra elástica, permitiu o diagnóstico mais acurado das alopecias cicatriciais primárias
BACKGROUND: Scarring alopecias are classified into primary and secondary according to the initial site of inflammation. In primary scarring alopecias, the hair follicle is the main target of destruction. The term secondary cicatricial alopecia implies that follicular destruction is not the primary pathologic event. AIMS: To review the histopathologic diagnoses of cases of cicatricial alopecia in order to classify them according to the North American Hair Research Society. PATIENTS AND METHODS: Patients with biopsy specimens diagnosed as cicatricial alopecia seen from 2000 to 2005 at the Dermatologic Department of Hospital das Clínicas, São Paulo University Medical School had hematoxylin and eosin, Periodic Acid-Schiff (PAS) and Weigert stained slides reevaluated and sub-typed into different primary cicatricial alopecias. RESULTS: Thirty-seven cases of primary cicatricial alopecias were reclassified as: discoid lupus erythematosus (16), lichen planus pilaris (4), pseudopelade of Brocq (12), folliculitis decalvans (3), dissecting folliculitis (1), and non-specific scarring alopecia (1). CONCLUSIONS: Even in late, pauci or noninflammatory phases, an approach with systematic evaluation of a constellation of criteria in routine hematoxylin and eosin stain, PAS and Weigert stain permitted an accurate diagnosis of cicatricial alopecias
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Manning, Lauren Brooke. "Experimental Evaluation of Discoid Domain Receptor 2 as an Ideal Target for Development of Disease-Modifying Osteoarthritis Drugs." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17331959.

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Abstract: Osteoarthritis (OA) affects 250 million people worldwide. Currently, no targets for disease-modifying osteoarthritis drugs exist. Matrix metalloproteinase-13 (MMP-13) would make it an ideal target; however, its broad biological effects restrict its application as a target enzyme of inhibitory drugs in the treatment of OA. The expression and activation of discoidin domain receptor 2 (DDR2) is increased in human OA tissues and mouse models of OA and was co-localized with elevated expression of MMP-13 in degenerative articular cartilages. In healthy articular cartilage, DDR2 is kept inactivated by the pericellular matrix, which separates the receptor from its ligand, type II collagen. Once enzymes capable of degrading the pericellular molecules expose chondrocytes to type II collagen, DDR2 is activated and induces expression of MMP-13 leading to degradation of type II collagen and proteoglycans resulting in joint destruction and OA. We tested the hypothesis that complete removal of Ddr2 from the knee joint of mouse adult articular cartilage can delay progression of osteoarthritis prior to or after initiation of articular cartilage degeneration. To accomplish this goal, conditional knock out techniques were used with Aggrecan-CreERT2 mice and floxed Ddr2 mice, Ddr2 was removed from articular cartilage of knee joints in mice at 8 weeks of age via intraperitoneal Tamoxifen injection (2mg/10g body weight) for 5 consecutive days (Group A). Mice were subjected to destabilization of the medial meniscus (DMM) or sham surgery at 10 weeks of age. An additional experimental group was subjected to DMM or sham surgery at 10 weeks of age and then DDR2 was removed by intraperitoneal Tamoxifen injection 8 weeks later (Group B). Knee joints from mice in Group A and their corresponding controls were harvested at 8 weeks or 16 weeks post-surgery and mice from Group B and their controls were harvested at 16 weeks post surgery. Histology was performed and the OARSI Modified Mankin Score was used to evaluate articular cartilage degeneration. Statistically significant differences were determined via T-test. We found the average modified score for Group A 8 week control was 1.64 (n=7) whereas with Ddr2 removed was 0.64 (n=7) [P<0.05]. 2) The average modified score for Group A 16 week control was 4.67 (n=7) and with Ddr2 removed was 1.27 (n=9) [P<0.05]. 3) The average modified score for Group B was 1.1 (n=5). In conclusion, conditional removal of Ddr2 in articular cartilage attenuated articular cartilage degeneration in mature knee joints of mouse models of OA.
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Gomes, Roberta Cunha. "Características clínicas e laboratoriais de 847 pacientes com lúpus eritematoso sistêmico juvenil em três grupos etários ao diagnóstico da doença: um estudo multicêntrico brasileiro." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-07022019-161409/.

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Introdução: A idade ao diagnóstico do lúpus eritematoso sistêmico juvenil (LESJ) pode influenciar a expressão da doença em termos de apresentação clínica inicial, padrão de envolvimento de órgãos e achados sorológicos. Objetivo: Avaliar dados demográficos, características clínicas e alterações laboratoriais no momento do diagnóstico da doença em três grupos etários diferentes de pacientes com LESJ: grupo A com início precoce (< 6 anos), grupo B com início em idade escolar ( >= 6 e < 12 anos) e grupo C com início em adolescentes ( >= 12 e < 18 anos). Métodos: Estudo multicêntrico brasileiro de coorte retrospectiva em 10 centros de reumatologia, incluindo 847 pacientes com o diagnóstico de LESJ. Resultados: Os pacientes foram divididos em três grupos: A com 39 (4%), B com 395 (47%) e C com 413 (49%). Dos 39 pacientes com LESJ do grupo A, 3 (8%) tinham < 2 anos, 4 (10%) >= 2 e < 3 anos e 32 (82%) >= 3 e < 6 anos. Setenta e quatro pacientes com LESJ foram analisados para os níveis séricos de C1q e a deficiência completa de C1q foi observada em 3/74 (4%), todos estes pertencentes ao grupo A. Os grupos foram semelhantes quanto às altas frequências de sexo feminino, nefrite, envolvimento neuropsiquiátrico, SLEDAI-2K ( >= 8), perfil de autoanticorpos, proteínas de fase aguda elevada e baixos níveis de complemento (p > 0,05). No entanto, as frequências de febre (78% vs. 61% vs. 47%, p < 0,0001), hepatomegalia (42% vs. 29% vs. 14%, p < 0,0001), esplenomegalia (28% vs. 12% vs. 4%, p < 0,0001) e lúpus discoide (13% vs. 4% vs. 4%, p=0,020) foram significantemente maiores no grupo A em comparação com os grupos B e C. As frequências de perda de peso > 2kg (19% vs. 28% vs. 36%, p < 0,017), fotossensibilidade (34% vs. 41% vs. 51% p < 0,006), leucopenia < 4.000/mm3 (14% vs. 25% vs. 30%, p=0,048) e linfopenia < 1.500/mm3 (22% vs. 41% vs. 47%, p=0,011) foram significantemente menores no grupo A. Conclusão: O presente estudo multicêntrico identificou que a apresentação inicial de LESJ foi caracterizada por alta frequência de envolvimento de órgãos internos nos três grupos estudados e algumas características clínicas e laboratoriais distintas nos grupos de início precoce e adolescentes
Introduction: Age at diagnosis of childhood-onset systemic lupus erythematosus (cSLE) may influence disease expression in terms of initial clinical presentation, pattern of organ involvement and serological findings. Objective: To evaluate demographic data, clinical and laboratory features at disease diagnosis in three different age groups of childhood systemic lupus erythematosus (cSLE): group A early-onset ( < 6 years), group B school age ( >= 6 and < 12 years) and group C adolescent ( >= 12 and < 18 years). Methods: Brazilian multicenter cohort retrospective study in 10 Pediatric Rheumatology centers, including 847 cSLE patients. Results: Patients were divided in three groups: A with 39 (4%), B 395 (47%) and C 413 (49%). Of 39 cSLE patients of group A, 3 (8%) were < 2 years, 4 (10%) >= 2 to < 3 years and 32 (82%) >= 3 and < 6 years. Seventy-four cSLE patients were analyzed for C1q levels and complete C1q deficiency was observed in 3/74 (4%), all of them of group A. Groups were similar regarding high frequencies of female gender, nephritis, neuropsychiatric involvement, SLEDAI-2K ( >= 8), autoantibody profile, elevated acute phase proteins and low complement levels (p > 0.05). However, the frequency of fever (78% vs. 61% vs. 47%, p < 0.0001), hepatomegaly (42% vs. 29% vs. 14%, p < 0.0001), splenomegaly (28% vs. 12% vs. 4%, p < 0.0001) and discoid lupus (13% vs. 4% vs. 4%, p=0.020) was significantly higher in the group A compared to groups B and C. The frequency of weight loss > 2kg (19% vs. 28% vs. 36%, p=0.017), photosensitivity (34% vs. 41% vs. 51%, p=0.006), leukopenia < 4,000/mm3 (14% vs. 25% vs. 30%, p=0.048) and lymphopenia < 1,500/mm3 (22% vs. 41% vs. 47%, p=0.011) was significantly lower in the group A. Conclusions: Our large multicenter study identified that the initial presentation of cSLE is characterized by comparable high frequency of internal organ involvement and some distinct clinical and laboratory features in early-onset and adolescent groups
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Daffara, Sara. "Non-flint raw materials in the European Middle Palaeolithic: variability of Levallois and discoid knapping methods and study of the supply areas." Doctoral thesis, Universitat Rovira i Virgili, 2020. http://hdl.handle.net/10803/669893.

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El projecte integra dades procedents de diferents matèries, és a dir, la tecnologia lítica, la caracterització i l'estudi de les àrees de subministrament de matèries primeres lítiques, per tal d'idefine les estratègies d'explotació d'ambdós territoris i matèries primeres litiques, emprades pels grups neandertals europeus, sobretot no siliceus matèries primeres, amb especial atenció a les estratègies d'explotació de vena quars. Per assolir els objectius de la recerca actual, s'han seleccionat quatre llocs europeus del Paleolític Mitjà. Tots els llocs comparteixen la presència en els seus conjunts lítics de quars de vena com a matèria primera principal o complementària i una significativa presència de seqüències de reducció de discoides i Levallois aplicades en diferents litologies (quarsita, quarsita, pórfir, síenita, sílex i xeringa). obtingudes a partir de l'estudi tecnològic dels conjunts lítics considerats, permeten definir per primer cop l'expedient tecnològic posat en marxa com a adaptació a les característiques mecàniques i petrogràfiques de les matèries primeres emprades en termes d'elecció dels espais naturals de conformació del nucli superfícies i desenvolupament de les seqüències de punt.
El proyecto integra datos procedentes de diferentes temas, es decir, tecnología lítica, caracterización y estudio de las áreas de suministro de materias primas líticas, con el fin de idear estrategias de explotación de ambos territorios y materias primas líticas, empleadas por grupos europeos de neandertales, especialmente no silíceas materias primas, con especial atención a las estrategias de explotación del cuarzo en las vetas. Para alcanzar los objetivos de la presente investigación, se han seleccionado cuatro sitios europeos del Paleolítico Medio. Todos los sitios comparten la presencia en sus ensamblajes líticos de cuarzo venoso como materia prima principal o complementaria y una presencia significativa de secuencias de reducción discoide y de Levallois aplicadas en diferentes litologías (cuarzo de vena, cuarcita, pórfido, sienita, pedernal y sílex). obtenidos del estudio tecnológico de los conjuntos líticos considerados permiten por primera vez definir el recurso tecnológico puesto en acción como adaptación a las características mecánicas y petrográficas de las materias primas empleadas en términos de elección de los espacios en blanco naturales, de la conformación del núcleo superficies y del desarrollo de las secuencias de corte.
The project integrates data coming from different subjects, i.e. lithic technology, characterization and study of the supply areas of lithic raw materials, in order to idefine exploitation strategies of both territories and lithic raw materials, employed by European Neanderthal groups, concerning especially non-siliceous raw materials, with particular attention for vein quartz exploitation strategies.To achieve the objectives of the present research, four Middle Paleolithic European sites have been selected. All the sites share the presence in their lithic assemblages of vein quartz as main or complementary raw material and a significant presence of discoid and Levallois reduction sequences applied on different lithologies (vein quartz, quartzite, porphyry, syenite, flint and chert).The results obtained from the technological study of the considered lithic assemblages allow for the first time to define the technological expedient put into action as adaptation to the mechanical and petrographic characteristics of the raw materials employed in terms of choice of the natural blanks, of shaping of the core surfaces and of development of the knapping sequences.
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Andrade, Lígia Marquez. "Obtenção de carreadores lipídicos nanoestruturados contendo clobetasol e tacrolimus e avaliação da permeação cutânea." Universidade Federal de Goiás, 2014. http://repositorio.bc.ufg.br/tede/handle/tede/7482.

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The use of topical medications, such as clobetasol propionate (CLO) and tacrolimus (TAC) is the main treatment for inflammatory skin diseases including discoid lupus erythematosus (DLE). The DLE is a chronic disease that affects the skin and its treatment can be improved with the simultaneous use of these drugs. However, this condition is difficult to treat topically because of the thickening of the stratum corneum (SC). New formulations such as lipid nanoparticles and the use of permeation enhancers can improve drug penetration in the skin and improve the topical treatment of different pathologies. Therefore, the aim of this study was to develop and characterize nanostructured lipid carriers (NLC) containing TAC and CLO and NLC coated or not with chitosan oligosaccharide (CO), in order to increase the skin permeation and retention of drugs. NLCs were prepared by the dilution of the microemulsion and were subsequently coated with OQ. The carriers obtained contained both drugs or TAC or CLO separately. The formulations obtained were evaluated for average diameter and polydispersity index (PDI), zeta potential, drug recovery (DR), encapsulation efficiency (EE) and drug loading (DL). The drug penetration from the NLC was assessed in pig ear skin in Franz cells. Co-encapsulated NLCs showed an average diameter of 143.3 nm and PdI of 0.264. The particles showed negative zeta potential of about -40 mV. After coating with OQ, NLCs showed a significant increase in diameter (311.9 nm) (p <0.05) and positive zeta potential (24,4mV) due to the adsorption of CO on the surface of the NLC. Co-encapsulation of the drug was effective, EE was greater than 90% for both TAC and CLO. In studies of electron paramagnetic resonance (EPR) it was observed that the drugs slightly modified the dynamics of lipids in NLC on the surface of the matrix (5-DSA). There was a significant increase in the 2A// parameter, the TAC+CLO-NLC (47,1G) compared to NLCs with no drug (45,6G). When the samples were coated with CO, the lipid dynamic modified considerably. The 2A// values increased from 45.5 to 50.1 in the NLC and 46.5 to 50.7 in the TAC+CLO-NLC. The CO probably forms a frame around the nanocarriers which significantly reduces the lipids mobility. The encapsulation of the drugs increased penetration of both TAC and CLO to the skin layers when compared to non-encapsulated drugs. The NLC coated increased the amount of TAC retained in the deeper layers of the skin (approximately 1.8 times more drug). For the CLO, the coating favored retention in the EC (1.7 fold) and on the remaining skin (3 times more drug) as compared to uncoated particles. When co-encapsulated with TAC and CLO, TAC’s penetration was superior compared with the particle containing only TAC. Thus, this strategy has shown to be promising to increase TAC’s skin penetration , which is a drug that hardly passes through the SC and promote greater retention of CLO in the upper layers of the skin. The results suggest that the co-encapsulated system is a potential formulation for skin drug delivery of the drugs.
O uso de medicamentos tópicos, como o propionato de clobetasol (CLO) e o tacrolimus (TAC), são o principal tratamento para doenças inflamatórias da pele incluindo o lúpus eritematoso discóide (LED). O LED é uma doença crônica que acomete a pele e pode ter seu tratamento melhorado com o uso simultâneo desses fármacos. Entretanto, essa condição é difícil de ser tratada topicamente devido ao espessamento do estrato córneo (EC). Novas formulações como nanopartículas lipídicas e a utilização de promotores da permeação, podem melhorar a penetração de fármacos na pele e aprimorar o tratamento de diferentes patologias tópicas. Sendo assim, o objetivo deste trabalho foi desenvolver e caracterizar carreadores lipídicos nanoestruturados (CLN) contendo TAC e CLO revestidos ou não com oligossacarídeo de quitosana (OQ), visando aumentar a permeação e retenção cutânea dos fármacos. Os CLN foram preparados pelo método de diluição da microemulsão e posteriormente foram revestidos com OQ. Foram obtidos carreadores contendo ambos os fármacos e carreadores contendo TAC ou CLO separadamente. As formulações obtidas foram avaliadas quanto ao diâmetro médio, índice de polidispersão (PdI), potencial zeta, recuperação do fármaco (REC%), eficiência de encapsulação (EE%) e carga de fármaco (CF%). A penetração dos fármacos a partir dos CLN foi avaliada em pele de orelha de porco em células de Franz. Os CLN com dupla encapsulação apresentaram diâmetro médio e PdI de 143,3 nm e 0,264, respectivamente. As partículas apresentaram potencial zeta negativo de aproximadamente -40 mV. Após o revestimento com OQ, os CLN apresentaram aumento significativo de diâmetro (311,9 nm) (p<0,05) e potencial zeta positivo (24,4mV), devido a adsorção de OQ na superfície dos CLN. A co-encapsulação dos fármacos mostrou-se eficiente, sendo que a EE% foi maior que 90% tanto para o TAC quanto para o CLO nas formulações obtidas. Nos estudos de Ressonância paramagnética eletrônica (RPE) foi possível observar que os fármacos modificaram um pouco a dinâmica dos lipídios do CLN na superfície da matriz (5-DSA). Observou-se um aumento significativo do parâmetro 2A//, das CLN-TAC+CLO (47,1G) em comparação com os CLN sem fármaco (45,6G). Quando as amostras foram revestidas com OQ a dinâmica dos lipídios modificou consideravelmente. Os valores de 2A// aumentaram de 45,5 para 50,1 nos CLN e de 46,5 para 50,7 nos CLN-TAC+CLO. Ou seja, o OQ provavelmente forma uma estrutura em torno dos nanocarreadores que reduz significativamente a mobilidade dos lipídios. A encapsulação dos fármacos nas partículas aumentou tanto a penetração do TAC quanto do CLO nas camadas da pele quando comparado com os fármacos não encapsulados. O revestimento do CLN com OQ aumentou a quantidade de TAC retido nas camadas mais profundas da pele (aproximadamente 1,8 vezes mais fármaco). Para o CLO, o revestimento dos CLN favoreceu tanto a retenção no EC (1,7 vezes mais) quanto na pele remanescente (3 vezes mais fármaco) em comparação com as partículas sem revestimento. Ainda, quando os dois fármacos estavam combinados nos CLN, a penetração do TAC foi superior quando comparado com a partícula contendo apenas TAC. Sendo assim, esta estratégia mostrou-se promissora para aumentar a penetração cutânea de TAC, que é um fármaco que dificilmente atravessa o EC e promover maior retenção de CLO nas camadas superficiais da pele. Os resultados sugerem que estes sistemas com dupla encapsulação podem apresentar potenciais benefícios para o tratamento de patologias cutâneas como o LED.
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Ramsey, Courtney Jade. "Tulips in Discord." Bowling Green State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1308862271.

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Alarcón, Peña Felipe Mauricio. "Physical conditions and kinematics in protoplanetary disks through line emission." Tesis, Universidad de Chile, 2019. http://repositorio.uchile.cl/handle/2250/170124.

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Tesis para optar al grado de Magíster en Ciencias, Mención Astronomía
Planetary Sciences are constantly progressing. Current facilities have allowed the discovery of a considerable amount of exoplanets and a more detailed study of protoplanetary disks, which is where planets are thought to form. Among the important tracers of disk evolution is the measurement of physical properties of these protoplanetary disks. This thesis focuses in two main parts; the first one in the diagnostic of gas line emission; while the second explores disks during even earlier stages of planet formation going through outbursts of accretion. In Chapter 2, we describe a line emission diagnostic that allows the measurement of temperature, turbulent broadening and the column density (particle number per unit surface) in protoplanetary disks. We test our line emission diagnostic through detailed analysis on post processed hydrodynamical simulations of a protoplanetary disk with an embedded giant planet. Our diagnostic could potentially allow the detection of kinematical signatures in line emission of planet-disk interactions, such as the Rossby wave (RWI) vortices associated with giant planet formation. We could conclude that our line emission diagnostic measures a kinematical signature in the disk, although very small. When the line emission diagnostic is applied to the hydrodynamical simulations, the measured turbulent velocity shows a small enhancement for optically thick molecular transitions at the location of the vortex. In Chapter 3, we explored an intriguing class of circumstellar objects, FU Orionis objects. FU Ori objects have outbursts with high accretion rates. They could solve the low luminosity problem in the formation of low mass stars. It is believed that low mass stars go through this phenomenon more than one time during their formation. Chapter 3 addresses how accretion outbursts shape the radial structure of the circumstellar disk in V883 Ori, a FU Ori object. With our approach, we measure its temperature and how fast it accretes. We use a self-iterative algorithm that takes the radial profile of a circumstellar source and returns its shape and how much it is accreting, separating optically thin with optically thick regimes. From our analysis of V883 Ori, we find that passive disk heating mechanisms do not reproduce the steep thermal profile of V883 Ori closer to the star than r=30 AU. Thus, we conclude that viscous dissipation provides the supplemental amount of energy necessary to generate the emission profile observed in V883 Ori.
Beca Magíster Nacional CONICYT, Millenium Nucleus "Protoplanetary Disk in Alma Early Science" y por el Departamento de Postgrado y Postítulo de la Vicerrectoría de Asuntos Acádemicos, Universidad de Chile
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Books on the topic "Discoid"

1

Salamoff, Paul J. Discord. Barnet, Heretfordshire: Markosia Enterprises, Ltd, 2011.

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Owbridge, Eileen. House of discord. South Yarmouth, Mass., USA: Curley, 1989.

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Salamoff, Paul J. Tales of Discord. Barnet, Hertfordshire, UK: Markosia Enterprises, Ltd., 2013.

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Owbridge, Eileen. House of discord. Bath: Chivers, 1989.

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House of discord. Toronto: Harlequin Books, 1987.

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Dying in discord. London: Headline, 2002.

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Cutler, Judith. Dying in discord. London: Headline, 2002.

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Dying in discord. Long Preston: Magna, 2005.

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Isella, Gilberto. Discordo. Locarno: Armando Dadò, 1993.

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Valéry, Reignaud, ed. Discorde. [Paris]: Bibliothèque interdite, 2007.

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Book chapters on the topic "Discoid"

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Brandner, Martina, and Angelika Klein-Theyer. "Lupus, Discoid." In Dermatological Cryosurgery and Cryotherapy, 513–16. London: Springer London, 2016. http://dx.doi.org/10.1007/978-1-4471-6765-5_94.

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Metze, Dieter, Tam Nguyen, Birgit Haack, Alexander K. C. Leung, Noriko Miyake, Naomichi Matsumoto, A. J. Larner, et al. "Discoid Eczema." In Encyclopedia of Molecular Mechanisms of Disease, 537. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_7765.

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Franks, Andrew G. "Discoid Lupus." In Encyclopedia of Medical Immunology, 356–60. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-0-387-84828-0_280.

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Lu, Qianjin. "Discoid SLE." In Encyclopedia of Medical Immunology, 360–65. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-0-387-84828-0_379.

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Shwayder, Tor, Samantha L. Schneider, Devika Icecreamwala, and Marla N. Jahnke. "Discoid Lupus." In Longitudinal Observation of Pediatric Dermatology Patients, 251–54. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-98101-7_34.

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Papadopoulos, A. "Discoid Meniscus: Histology." In The Meniscus, 247–49. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-02450-4_32.

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Oboite, Michelle E., and Porcia B. Love. "Discoid Lupus Erythematosus." In Clinical Cases in Skin of Color, 3–13. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-23615-5_1.

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Vaso, Kecojević. "Discoid Meniscus: Histology." In Surgery of the Meniscus, 119–22. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-49188-1_11.

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Rudnicka, Lidia, Malgorzata Olszewska, and Adriana Rakowska. "Discoid Lupus Erythematosus." In Atlas of Trichoscopy, 303–17. London: Springer London, 2012. http://dx.doi.org/10.1007/978-1-4471-4486-1_23.

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Ahn, Jin Hwan, and Sang Hak Lee. "Discoid Lateral Meniscus." In Knee Arthroscopy, 201–15. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-8191-5_17.

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Conference papers on the topic "Discoid"

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Smith, Chadwick F., Eda Van Dyk, John Jurgutis, and C. Thomas Vangsness. "Cautious surgery for discoid menisci." In Photonics West '95, edited by R. Rox Anderson, Graham M. Watson, Rudolf W. Steiner, Douglas E. Johnson, Stanley M. Shapshay, Michail M. Pankratov, George S. Abela, et al. SPIE, 1995. http://dx.doi.org/10.1117/12.209063.

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Kesede, R. Julio, Luan L. Lee, and J. W. M. Bassani. "Automatic identification of Discoid Lupus Erythematosus." In 2011 ISSNIP Biosignals and Biorobotics Conference: Biosignals and Robotics for Better and Safer Living (BRC). IEEE, 2011. http://dx.doi.org/10.1109/brc.2011.5740668.

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"02 Management of refractory discoid lupus." In 8th ANNUAL MEETING OF THE LUPUS ACADEMY, Warsaw, Poland, September 6–8, 2019. Lupus Foundation of America, 2019. http://dx.doi.org/10.1136/lupus-2019-la.20.

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Dumas, Antonio, and Michele Trancossi. "Passive Attitude Control for Discoid Aerial Vehicles." In Aerospace Technology Conference and Exposition. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 2011. http://dx.doi.org/10.4271/2011-01-2787.

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Bochkarev, Vadim, and Pavel Kuznetsov. "Stages of evolution of discoid cheek-pieces in Northern Eurasia." In Antiquities of East Europe, South Asia and South Siberia in the context of connections and interactions within the Eurasian cultural space (new data and concepts). Institute for the History of Material Culture Russian Academy of Sciences, 2019. http://dx.doi.org/10.31600/978-5-907053-35-9-160-162.

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Nakagawa, K., and H. Hasegawa. "Three-Dimensional Vortex Structure in the Wake of an Oscillating Discoid Airfoil." In ASME-JSME-KSME 2011 Joint Fluids Engineering Conference. ASMEDC, 2011. http://dx.doi.org/10.1115/ajk2011-16035.

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Flow fields around an oscillating airfoil at the low Reynolds number region are extremely unsteady because the change direction of leading edge produces unsteady vortex motions. Studies of unsteady propulsion system of birds, insects, and fish are few and inconclusive. It has been noted that the unsteady fluid force plays an important role in biological flight. To evaluate the force correctly, it is necessary to know the unsteady properties determined from the vortex dynamics. The actual motion of a hand in swimming is obviously unsteady, and time-dependent fluid forces must be considered, because a quasi-steady-state approach towards predicting the fluid forces acting on a hand under unsteady conditions yielded errors. The three-dimensionality and the unsteady effect of a hand must be important to the estimation of the fluid forces acting on a swimmer’s hand. The purpose of this study is to investigate the relationship between unsteady fluid forces and vortex structures for a three-dimensional airfoil during the pitch-oscillating motion. Particle image velocimetry (PIV) was used to aid in understanding the flow field in the near field of the airfoil edge for the wind tunnel test. It is confirmed that the unsteady fluid forces were affected by the vortices shed from the airfoil edge during up-stroke in pitching oscillation. There are two peaks in the fluid force during one pitch-oscillating due to the vortex behavior. The vortex behavior was strongly affected by the reduced frequency, and the fluid force acting on the airfoil model increases with increasing the reduced frequency.
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Endo, G., H. Yamada, and S. Hirose. "Development of a light duty arm with an active-fingertip gripper for handling discoid objects." In 2010 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS 2010). IEEE, 2010. http://dx.doi.org/10.1109/iros.2010.5654010.

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Mughni, Fadhli Aulia, Randy Satria Nugraha, Eyleny Meisyah Fitri, Tjhin Wiguna, and Windy Keumala Budianti. "Acute Cutaneous and Generalized Discoid Lupus Erythematosusin Systemic Lupus Erythematosus with Neuropsychiatric Complications: A Multidisciplinary Approach." In The 2nd International Conference on Tropical Medicine and Infectious Disease. SCITEPRESS - Science and Technology Publications, 2019. http://dx.doi.org/10.5220/0009987803200324.

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Son, Mai Thai, and Duong Tuan Anh. "EWAT+: Finding Time Series Discords Based on New Discord Measure Functions." In Communication Technologies, Research, Innovation, and Vision for the Future (RIVF). IEEE, 2010. http://dx.doi.org/10.1109/rivf.2010.5633138.

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Jamaluddin, Moideen P. "PLATELET AGGREGATION DOES NOT CONFORM TO SIMPLE PARTICLE COLLISION THEORY." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644550.

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Platelet aggregation kinetics, according to the particle collision theory, generally assumed to apply, ought to conform to a second order type of rate law. But published data on the time-course of ADP-induced single platelet recruitment into aggregates were found not to do so and to lead to abnormal second order rate constants much larger than even their theoretical upper bounds. The data were, instead, found to fit a first order type of rate law rather well with rate constants in the range of 0.04 - 0.27 s-1. These results were confirmed in our laboratory employing gelfiltered calf platelets. Thus a mechanism much more complex than hithertofore recognized, is operative. The following kinetic scheme was formulated on the basis of information gleaned from the literature.where P is the nonaggregable, discoid platelet, A the agonist, P* an aggregable platelet form with membranous protrusions, and P** another aggregable platelet form with pseudopods. Taking into account the relative magnitudes of the k*s and assuming aggregation to be driven by hydrophobic interaction between complementary surfaces of P* and P** species, a rate equation was derived for aggregation. The kinetic scheme and the rate equation could account for the apparent first order rate law and other empirical observations in the literature.
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Reports on the topic "Discoid"

1

Hilliard, N., and D. Freedman. A Discard Prefix for IPv6. RFC Editor, August 2012. http://dx.doi.org/10.17487/rfc6666.

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Malik, Mohan. China and the East Asian Summit: More Discord than Accord. Fort Belvoir, VA: Defense Technical Information Center, February 2006. http://dx.doi.org/10.21236/ada493763.

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Beiriger, Judy, Rupert K. Byers, Martha J. Ernest, Sue P. Goudy, John P. Noe, Thomas J. Pratt, David N. Shirley, Thomas D. Tarman, Walter H. VanDevender, and David P. Wiltzius. DISCOM2: Distance Computing the SP2 Pilot FY98 Report. Office of Scientific and Technical Information (OSTI), May 1999. http://dx.doi.org/10.2172/7018.

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van Overzee, Harriet, Michiel Dammers, and Katinka Bleeker. Discard self-sampling of Dutch bottom-trawl fisheries in 2017-2018. IJmuiden: Stichting Wageningen Research, Centre for Fisheries Research (CVO), 2019. http://dx.doi.org/10.18174/510188.

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van Overzee, Harriet, Katinka Bleeker, and Michiel Dammers. Discard self-sampling of the Dutch bottom-trawl fisheries in 2019. IJmuiden: Stichting Wageningen Research, Centre for Fisheries Research (CVO), 2021. http://dx.doi.org/10.18174/539162.

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McElvain, Jean, Monica Sklar, and Madeline Harpham. Dior to disco: Second wave feminism and fashion. Ames: Iowa State University, Digital Repository, 2017. http://dx.doi.org/10.31274/itaa_proceedings-180814-329.

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Verkempynck, Ruben, Harriet van Overzee, and Michiel Dammers. Discard self-sampling of Dutch bottom-trawl and seine fisheries in 2014-2016. IJmuiden: Stichting Wageningen Research, Centre for Fisheries Research (CVO), 2018. http://dx.doi.org/10.18174/446002.

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Verkempynck, Ruben, Thomas Brunel, Jan Jaap Poos, and Jurgen Batsleer. Best practice II: effect of discard survival on North Sea sole and plaice. IJmuiden: Wageningen Marine Research, 2018. http://dx.doi.org/10.18174/462554.

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Clark, A., G. Zorn, and Q. Wu. RTP Control Protocol (RTCP) Extended Report (XR) Block for Discard Count Metric Reporting. RFC Editor, September 2013. http://dx.doi.org/10.17487/rfc7002.

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Clark, A., and R. Huang. RTP Control Protocol (RTCP) Extended Report (XR) Block for Burst/Gap Discard Metric Reporting. Edited by Q. Wu. RFC Editor, September 2013. http://dx.doi.org/10.17487/rfc7003.

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