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Journal articles on the topic 'Discoid lupus erythematosus (DLE)'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Khallaayoune, Mehdi, Siham Belmourida, Fatima Azzahra Elgaitibi, and Mariame Meziane. "Eyelid discoid lupus erythematosus." Our Dermatology Online 12, e (2021): e28-e28. http://dx.doi.org/10.7241/ourd.2021e.28.

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Discoid lupus erythematosus (DLE) most commonly affects the face and scalp. Palpebral involvement is rare and not evocative when presenting as the prime manifestation of the disease. We report hereby the case of a young male patient with isolated palpebral and labial DLE. A 34-year-old patient with no medical history was referred from ophthalmology for an erythematous plaque of the eyelid resisting usual treatment of blepharitis. Skin examination revealed a congestive erythema on the right lower eyelid with eyelash fall (Fig. 1). There was also an atrophic cheilitis of the lower lip with sligh

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Le, Marilyn, Payvand Kamrani, and L. Claire Hollins. "Coexistentence of Morphea and DLE in a Patient with Beta Thalassemia Leading to a Diagnosis of Systemic Lupus Erythematous." SKIN The Journal of Cutaneous Medicine 6, no. 3 (2022): 243–45. http://dx.doi.org/10.25251/skin.6.3.11.

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Patients with autoimmune disorders are predisposed to developing a second autoimmune condition. This can be applied to cutaneous conditions as well. Morphea or localized scleroderma is an autoimmune inflammatory and fibrosing skin disorder due to increased collagen deposition.1,2 Patients with morphea are four times likelier of having a concomitant autoimmune disease.1 There have been cases of systemic lupus erythematosus (SLE) with morphea, but the co-occurrence of discoid lupus erythematosus (DLE) with morphea has been rarely reported, and never reported in patient with Beta-thalamessmia.1,2

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3

Karasińska, Aneta, Adriana Polańska, Monika Bowszyc‑Dmochowska, Ryszard Żaba, Zygmunt Adamski, and Aleksandra Dańczak‑Pazdrowska. "Discoid lupus erythematosus – a case report, diagnostic and therapeutic difficulties." Journal of Face Aesthetics 4, no. 2 (2021): 135–44. http://dx.doi.org/10.20883/jofa.51.

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Discoid lupus erythematosus is the most common clinical manifestation of lupus erythematosus. Characteristic features are erythematous plaques with follicular hiperkeratosis, clearly demarcated from surrounding skin, that resolve with atrophy and scarring, leading to significant aesthetic defects. The consequence of involving the scalp is cicatrical alopecia. On the ground of long lasting, untreated lesions squamous cell carcinoma (SCC) may develop. On the other hand SCC remains in the circle of DLE differentiation. We present diagnostic and therapeutic difficulties associated with DLE.

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4

Donaldo, Emiliano Silva López, Antonio Velarde Chávez José, Elisa González Robles María, Fernanda Romero Rivera María, Villaseñor Angulo Saúl, and Alejandra Solano Mendoza Alma. "Considerations in Discoid Lupus: A Comprehensive Review." INTERNATIONAL JOURNAL OF MEDICAL SCIENCE AND CLINICAL RESEARCH STUDIES 04, no. 05 (2024): 818–21. https://doi.org/10.5281/zenodo.11146570.

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Discoid lupus erythematosus (DLE) is a chronic inflammatory skin condition that can lead to disfiguring scarring and pigmentary changes. This review article provides an overview of the epidemiology, pathogenesis, clinical manifestations, and treatment options for DLE. Special considerations in the management of DLE, including the role of photoprotection, topical and systemic therapies, and the importance of multidisciplinary care, are discussed. The impact of DLE on quality of life and psychosocial well-being is also addressed. A better understanding of the complexities of DLE can aid clinicia

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5

Nakamura, Satoshi, Tomoko Yamada, Naoka Umemoto, et al. "Cheek and Periorbital Peculiar Discoid Lupus Erythematosus: Rare Clinical Presentation Mimicking Tinea Faciei, Cutaneous Granulomatous Disease or Blepharitis." Case Reports in Dermatology 7, no. 1 (2015): 56–60. http://dx.doi.org/10.1159/000381208.

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We present clinically peculiar facial discoid lupus erythematosus (DLE) that mimicked tinea faciei. Although DLE is a chronic autoimmune dermatosis, it has a variety of rare clinical presentations, including periorbital DLE, comedonic DLE and hypertrophic DLE recently. In this case, a scaly, erythematous lesion on the eyelid and the central healed, mildly elevated, annularly distributed facial DLE mimicked tinea faciei, complicating our diagnosis.

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Devaraj, Yogesh, Belagola Dasegowda Sathyanarayana, Mukunda Ranga Swaroop, Sowmya Shree H., Mithila Ravindranath, and Avik Ghosh. "Discoid lupus erythematosus in acro-orificial vitiligo." International Journal of Research in Dermatology 4, no. 3 (2018): 456. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20183178.

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<p class="abstract">Discoid lupus erythematosus (DLE) is an autoimmune disease characterized by atrophic and discoid plaques over sun-exposed areas of skin and is the most common form of chronic cutaneous lupus erythematosus. Vitiligo is also an autoimmune disease known to be associated with other autoimmune conditions. However coexistence of DLE and vitiligo has been reported uncommonly. We report a case of a 60-year-old lady who developed DLE lesions over pre-existing vitiligo lesions.</p>

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7

Almurayshid, Abdurrahman, and Sulaiman Al Obaid. "Isolated Linear Discoid Lupus Erythematosus of Scalp Following Lines of Blaschko." Open Dermatology Journal 13, no. 1 (2019): 58–60. http://dx.doi.org/10.2174/1874372201913010058.

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Discoid lupus erythematosus (DLE) is an inflammatory autoimmune disease leading to scarring and hair loss. Linear Discoid lupus erythematosus has been mentioned in the literature as a rare variant. This article describes isolated linear DLE of the scalp. We present a 26-year-old Saudi male who had unilateral linear DLE of the scalp with no involvement of other body sites and no systemic manifestations. This case is the first case of isolated linear DLE on the scalp. This presentation should be considered as a differential diagnosis of linear scarring alopecia as a distinct morphological patter

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Chikhalkar, Siddhi Bhalchandra, Surender Singh, Avani Jatin Kumar Shah, Bhushan Madke, and Yallappa Ramchandrappa Kabbannavar. "Halting the Progression of Cicatricial Alopecia with Injectable Platelet-Rich Fibrin." International Journal of Trichology 15, no. 4 (2023): 163–66. http://dx.doi.org/10.4103/ijt.ijt_116_21.

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Discoid lupus erythematosus (DLE) is a chronic variant of cutaneous lupus erythematosus characterized by well-defined erythematous plaques with adherent scales and follicular plugging. The affected scalp shows erythema, edema, atrophy, alopecia, and telangiectasia. Trichoscopy of DLE shows branching capillaries, white patches, keratin plugs, reduced follicular ostia, and white dots and blue-gray dots arranged in speckles pattern. Prompt diagnosis and aggressive, early multimodal therapy helps in preventing disfiguring hair loss and psychosocial sequelae. Hereby, we present a case of reversal o

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9

Kishore Kumar, Pasupuleti, Pasumala Varun, Thokala Ruchitha, Chinta Rohit Kumar, and T. Rama Rao. "A case report on discoid lupus erythematosus." Indian Journal of Case Reports 11, no. 4 (2025): 169–71. https://doi.org/10.32677/ijcr.v11i4.5024.

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Inflammatory plaques are a hallmark of discoid lupus erythematosus (DLE), a chronic cutaneous illness that can cause skin shrinkage and disfiguring scarring if left untreated. The best treatments, however, are not well supported by the available data. As of right now, no drugs have been authorized expressly to treat DLE. This uncommon ailment manifests as a crimson telangiectatic lesion in the oral cavity, surrounded by white patches in the mucous membrane. Occasionally, thick or thin white papillary radiating patterns are visible around the lesion as extremely thin lines. Here, we present a 2

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10

Rai, Harishchandra, Anitha Dayakar, Supriya H., and Elizabeth Sojan. "Discoid lupus erythematosus with epithelial dysplasia: a case report." International Journal of Research in Medical Sciences 5, no. 6 (2017): 2833. http://dx.doi.org/10.18203/2320-6012.ijrms20172501.

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Lupus erythematosus is a classic example of an immunologically mediated condition and is one of the most common of the so called “collagen vascular” or connective tissue diseases. Lupus erythematosus was first described by Biett in 1828 and Kaposi in 1872. Development of squamous cell carcinoma (SCC) can occur in DLE, with about 20 cases reported in the world literature to-date, which led the World Health Organization (WHO) to classify DLE as one of the precancerous conditions. Thus malignant changes in such a condition must be given utmost importance. This article focuses on a rare case of DL

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11

Ambrogio, Francesca, Caterina Foti, Silvia Noviello, et al. "Can Dermoscopy Be a Useful Follow-Up Tool in Patients with Discoid Lupus Treated with Anifrolumab?" Diagnostics 15, no. 5 (2025): 522. https://doi.org/10.3390/diagnostics15050522.

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This report discusses a female patient with longstanding discoid lupus erythematosus (DLE) and systemic lupus erythematosus (SLE), refractory to multiple immunosuppressive and biologic treatments. Upon presenting with infiltrated, hypertrophic plaques in facial and décolletage regions, she was started on anifrolumab therapy after the histopathological confirmation of DLE. Following three infusions, significant clinical and dermoscopic improvements were observed, including the resolution of plaques and regression of scarring areas. This case highlights anifrolumab’s efficacy in severe lupus ski

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12

Jin, Shiyu, Shiwen Wang, Sha Jin, Chenyu Tang, and Ping Wang. "A case of vitiligo secondary to discoid lupus erythematosus treated with tofacitinib." Medicine 104, no. 26 (2025): e43118. https://doi.org/10.1097/md.0000000000043118.

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Rationale: Vitiligo is a common autoimmune disorder characterized by melanocyte destruction, leading to depigmented patches. It is often associated with other autoimmune diseases, including thyroid disease and systemic lupus erythematosus. Discoid lupus erythematosus (DLE) is a prevalent form of cutaneous lupus, and both conditions involve the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway. However, the co-occurrence of vitiligo secondary to DLE is rare, and therapeutic approaches remain challenging. This case highlights the potential role of tofacit

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13

Sohn, Alice, Nicole Bouché, George Michael Lewitt, and Eingun James Song. "Successful Treatment of Refractory Discoid Lupus Erythematosus with Deucravacitinib." SKIN The Journal of Cutaneous Medicine 8, no. 4 (2024): 1742–46. http://dx.doi.org/10.25251/skin.8.4.18.

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Discoid lupus erythematosus (DLE) is the most common subtype of chronic cutaneous lupus erythematosus (CLE) that may present with or without systemic lupus erythematosus (SLE). Treatment for DLE remains limited, as there are no medications specifically approved to treat DLE. Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 (TYK2) inhibitor, is currently being studied for adults with moderate-to-severe discoid and/or subacute CLE. We report a case of successful treatment of refractory DLE with deucravacitinib. A 65-year-old female with a longstanding history of systemic lupus e

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Gopalan, Geetharani, Sudha R. Gopinath, Kothandaramasamy R., and Sathesh Pandian. "A clinical and epidemiological study on discoid lupus erythematosus." International Journal of Research in Dermatology 4, no. 3 (2018): 396. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20183165.

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<p class="abstract"><strong>Background:</strong> Discoid lupus erythematosus (DLE) is the commonest form of cutaneous lupus erythematosus.The objective of our study is to analyze the clinical and epidemiological aspects of DLE.</p><p class="abstract"><strong>Methods:</strong> All clinically diagnosed cases of DLE attending the dermatology OPD from October 2010 to September 2012were included in the study. A detailed history, complete physical examination, biopsy for confirmation and other relevant investigations were done in all cases.<strong><

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15

H. J., Dadapeer, Anupama Y. G., and Sushma D. M. "Discoid lupus erythematosus leading to squamous cell carcinoma: a case report." International Journal of Research in Dermatology 3, no. 3 (2017): 456. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20173930.

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<p><span>Discoid lupus erythematosus (DLE) is the most common chronic form of cutaneous lupus. It is characterised by persistent scaly, disk-like plaques on scalp, face and ears that may cause pigmentary changes, scarring and hair loss. </span><span class="apple-converted-space"><span>Squamous cell carcinoma can</span></span><span> rarely arise within a longstanding DLE plaque<span class="apple-converted-space"> </span>in the skin. It presents as an enlarging warty<span class="apple-converted-space"> </span>growth or ulcer

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Hashas, Fatima Zahra, Sara Elloudi, Sara El Ammari, et al. "Trichoscopy of connectivitises: Discoid lupus erythematosus or dermatomyositis?" Our Dermatology Online 14, no. 4 (2023): 389–92. http://dx.doi.org/10.7241/ourd.20234.9.

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ABSTRACT Background: Discoid lupus erythematosus (DLE) and Sdermatomyositis (DM) are two connectivitises with frequent scalp involvement and similar clinical features. Objective: The objective of this study was to evaluate and compare the trichoscopic findings in patients with DM and DLE and to determine the distinctive feature of each pathology that may help in the differential diagnosis. Materials and Methods: We performed an analytical, comparative primary study of trichoscopic images belonging to 32 patients (18 cases of lupus and 14 of dermatomyositis) with a total of seventy lesions over

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17

Silver, Shane G., H. Chih-Ho Hong, Patricia T. Ting, and Nigel J. Ball. "Kikuchi—Fujimoto's Necrotizing Lymphadenitis in Association with Discoid Lupus Erthematosus: A Case Report." Journal of Cutaneous Medicine and Surgery 8, no. 6 (2004): 442–45. http://dx.doi.org/10.1177/120347540400800607.

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Background: Kikuchi–Fujimoto's necrotizing lymphadenitis (KFNL) is a rare, benign, self-limited condition characterized by constitutional symptoms, lymphadenopathy, and skin lesions. Objective: We report a case of KFNL in a 43-year-old East Indian woman with a ten-year history of discoid lupus erythematosus (DLE) of the scalp and a three-month history of a erythematous plaque on the left nasal bridge, cervical lymphadenopathy, and fever. Skin biopsy samples were taken from the face and lymph node. Results: Histopathological examination of the skin revealed a mixed infiltrate of inflammatory ce

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Rossi, Michael A., Linda M. Messinger, Keith E. Linder, and Thierry Olivry. "Generalized Canine Discoid Lupus Erythematosus Responsive to Tetracycline and Niacinamide Therapy." Journal of the American Animal Hospital Association 51, no. 3 (2015): 171–75. http://dx.doi.org/10.5326/jaaha-ms-6116.

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Discoid lupus erythematosus (DLE) is a commonly reported canine autoimmune disease that normally presents with a phenotype consisting of erythema, depigmentation, scaling, erosions/ulcers, and scarring over the nasal planum and the proximal dorsal muzzle. Recently, two cases of a generalized variant of this disease have been reported, whose lesions responded to either systemic glucocorticoids or a combination of topical corticosteroids, topical tacrolimus, and the oral antimalarial hydroxychloroquine. The purpose of this report is to describe an 11 yr old shih tzu that presented with skin lesi

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GOO, Moon-Jung, Jin-Kyu PARK, Il-Hwa HONG, et al. "Discoid Lupus Erythematosus (DLE) in a Spitz Dog." Journal of Veterinary Medical Science 70, no. 6 (2008): 633–35. http://dx.doi.org/10.1292/jvms.70.633.

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20

Figueiredo Pires Coelho, Ana Beatriz, Diogo Emanuel Loureiro de Sousa, and Anabela Almeida Madeira. "Recurrent erosive-crusted ear lesions in a middle-aged woman: a case of discoid lupus erythematosus." Iberoamerican Journal of Medicine 7, no. 2 (2025): 64–68. https://doi.org/10.53986/ibjm.2025.0009.

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Discoid lupus erythematosus (DLE) is a chronic autoimmune skin condition characterized by erythematous scaly plaques, often resulting in scarring and pigmentary changes. It primarily affects sun-exposed areas and is more common in women aged 20-40. Although predominantly a skin condition, it can progress to systemic lupus erythematosus, warranting long-term monitoring. In this article, we e present the case of a 40-year-old woman with an 8-year history of recurrent erosive and crusted lesions on both earlobes, extending to the helix, with local atrophy. Biopsy revealed DLE. The patient respond

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Concha, Josef Symon Salgado, and Victoria P. Werth. "Alopecias in lupus erythematosus." Lupus Science & Medicine 5, no. 1 (2018): e000291. http://dx.doi.org/10.1136/lupus-2018-000291.

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Several patterns of hair loss can occur in lupus erythematosus (LE). Alopecias which show histological characteristics of LE are LE-specific, and include discoid LE (DLE), diffuse or patchy hair loss in acute LE, subacute cutaneous LE, and rarely tumid LE. Lupus hair in SLE is a poorly characterised entity and may be a form of telogen effluvium. Alopecia areata can coexist with LE and may mimic DLE. Non-lupus alopecias such as telogen effluvium and anagen effluvium have a myriad of causes which include disease flares, drugs and stress in the setting of LE. The latest validated Systemic Lupus I

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De Francesco, Vincenzo, Enzo Errichetti, Enrico Pegolo, and Giuseppe Stinco. "Atypical Fibroxanthoma Arising in a Scar of Discoid Lupus Erythematosus." Journal of Cutaneous Medicine and Surgery 18, no. 5 (2014): 353–55. http://dx.doi.org/10.2310/7750.2013.13144.

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Background: Malignant change in the scars of discoid lupus erythematosus (DLE) is a well-known event. In most cases, tumors are of epithelial origin, particularly squamous cell carcinomas and, less frequently, basal cell carcinomas and keratoacanthomas. The onset of soft tissue sarcomas in a DLE scar is a very rare event, however, because only one case of malignant fibrous histiocytoma has been described in the literature. Objective: We describe the first documented report of atypical fibroxanthoma (AFX) arising in an old scar of DLE. Results: Although we cannot exclude an accidental associati

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Pons-Estel, G. J., L. D. Aspey, G. Bao, et al. "Early discoid lupus erythematosus protects against renal disease in patients with systemic lupus erythematosus: longitudinal data from a large Latin American cohort." Lupus 26, no. 1 (2016): 73–83. http://dx.doi.org/10.1177/0961203316651740.

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Objectives The objective of this study was to examine whether early discoid lupus erythematosus (DLE) would be a protective factor for further lupus nephritis in patients with systemic lupus erythematosus (SLE). Methods We studied SLE patients from GLADEL, an inception longitudinal cohort from nine Latin American countries. The main predictor was DLE onset, which was defined as physician-documented DLE at SLE diagnosis. The outcome was time from the diagnosis of SLE to new lupus nephritis. Univariate and multivariate survival analyses were conducted to examine the association of DLE onset with

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Jost, Sheridan A., Lin-Chiang Tseng, Loderick A. Matthews, et al. "IgG, IgM, and IgA Antinuclear Antibodies in Discoid and Systemic Lupus Erythematosus Patients." Scientific World Journal 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/171028.

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IgG antinuclear antibodies (ANAs) are elevated in patients with systemic lupus erythematosus (SLE) compared with patients with discoid lupus erythematosus (DLE). To provide an expanded immunologic view of circulating ANAs in lupus patients, we compared the expressions of IgG, IgM, and IgA ANAs in DLE and SLE patients. In this cross-sectional study, sera from age-, gender-, and ethnic-matched SLEN=35, DLEN=23, and normal patientsN=22were tested for IgG, IgM, and IgA ANAs using enzyme-linked immunosorbent assays (ELISAs) and indirect immunofluorescence (IIF) with monkey esophagus as substrate. E

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Yu, Amy W., Eli J. Finkelsztein, and Natalie T. Cheng. "A Case of Tolosa-Hunt Syndrome With Discoid Lupus Erythematosus." Neurohospitalist 10, no. 1 (2019): 48–50. http://dx.doi.org/10.1177/1941874419828603.

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The occurrence of Tolosa-Hunt syndrome (THS) in the setting of discoid lupus erythematosus (DLE) has not been previously reported. We report a case of a 55-year-old Chinese man with established cutaneous lupus who presented with 1 week of worsening blurry vision and ptosis of the left eye with severe headache 2 weeks prior to presentation. His cranial nerve examination was significant for left afferent pupillary defect, red desaturation, ptosis, and oculomotor nerve palsy. He also presented with active DLE lesions. Magnetic resonance imaging brain demonstrated asymmetric thickening and enhance

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Martins, Priscila Reis, Thelma Skare, Thiago Augusto Ferrari, Ana Paula Franchetti Silva, and Bruna Fabiana Vianna Alessio. "Comparative analysis of the quality of life of patients with discoid lupus erythematosus and systemic lupus erythematosus with skin injuries." Anais Brasileiros de Dermatologia 87, no. 2 (2012): 326–28. http://dx.doi.org/10.1590/s0365-05962012000200028.

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Lupus erythematosus is an autoimmune disease of unknown etiology with cutaneous and vascular lesions. Both discoid lupus erythematosus (DLE) and systemic lupus (SLE) affect the skin. Visible skin lesions in young women can cause loss of self esteem. In the present study we aimed to evaluate and compare the quality of life in SLE and LED through an observational study of 64 patients. These patients were divided into 2 groups: Group 1: SLE (n = 38); group 2: DLE (n = 26) and then completed the quality of life questionnaire - Dermatology Life Quality Index or DLQI. It was found that patients with

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Saghafi, Massoud, Kamila Hashemzadeh, Sima Sedighi, et al. "Evaluation of the Incidence of Discoid Lupus Erythematosus in Patients with Systemic Lupus Erythematosus and Its Relationship to Disease Activity." Journal of Cutaneous Medicine and Surgery 18, no. 5 (2014): 316–19. http://dx.doi.org/10.2310/7750.2014.13122.

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Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with wide clinical features ranging from cutaneous manifestations to systemic disease. Skin is one of the most commonly affected organs in SLE. Objective: To determine whether there is any correlation between discoid lupus erythematosus (DLE) and the severity of SLE. Methods: In a prospective cross-sectional study, 60 consecutive patients with newly diagnosed SLE were enrolled. Skin biopsy was performed to establish the diagnosis of DLE. Disease activity was determined by the Systemic Lupus Erythematosus Disease Act

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Takezawa, K., I. Ueda-Hayakawa, F. Yamazaki, N. Kambe, Y. Son, and H. Okamoto. "Successful treatment with hydroxychloroquine for systemic lupus erythematosus with cutaneous involvement accompanied by a xanthomatous reaction." Lupus 29, no. 1 (2019): 79–82. http://dx.doi.org/10.1177/0961203319890677.

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Antimalarials are usually recommended for the first-line systemic treatment of cutaneous lupus erythematosus. Alopecia in patients with discoid lupus erythematosus (DLE) is sometimes a refractory condition in spite of topical therapies. We herein described a case of DLE on the scalp with a pathological change of a xanthomatous reaction, which was successfully treated with hydroxychloroquine (HCQ). A 34-year-old woman presented with hair loss to the parietal region. She had been diagnosed with systemic lupus erythematosus (SLE) four years previously. Treatment with 30 mg/day of prednisolone (PS

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Afroz, Farzana, Tamanna Naznin, Tawfique Raffat Islam, Sabrina Razzaque, and Tamanna Choudhury. "A Female with Unilateral Facial Discoid Lupus Erythematosus-An Unusual Presentation: A Case Report in Bangladesh." Journal of the Medical College for Women & Hospital 21, no. 1 (2025): 95–99. https://doi.org/10.3329/jmcwh.v21i1.80953.

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Lupus erythematosus (LE) is a chronic autoimmune disease with a diverse array of clinical illness among which Discoid Lupus Erythematosus (DLE) is one of the commonest forms involving the integumentary system mostly. Usually, classic DLE lesions exhibit some common features like discoid shape, dyspigmentation, adherent scale and atrophy, but sometimes these classic scenario may be absent. In case of atypical presentation, clinical assessment of the disease may aid in early diagnosis and prompt treatment of the condition. This would help prevent disfigurements, progression to systemic disease a

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Calza, Leonardo, Roberto Manfredi, Vincenzo Colangeli, Antonietta D'Antuono, Beatrice Passarini, and Francesco Chiodo. "Systemic and discoid lupus erythematosus in HIV-infected patients treated with highly active antiretroviral therapy." International Journal of STD & AIDS 14, no. 5 (2003): 356–59. http://dx.doi.org/10.1258/095646203321605585.

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Although HIV infection is often associated with several rheumatic diseases, the coexistence of this retroviral infection and systemic lupus erythematosus (SLE) is extremely uncommon. Generally, HIV-related immunosuppression improves SLE symptoms, and antiretroviral therapy may lead to an autoimmune disease flare subsequent to the increase of circulating CD4+ cell number. Two HIV-infected female patients with SLE and discoid lupus erythematosus (DLE) diagnosed a few months after the highly active antiretroviral therapy initiation, are described. To our knowledge, this is the second case of DLE

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Merlin, F., T. Prochilo, B. Kildani, et al. "Discoid lupus erythematosus (DLE)-like lesions induced by capecitabine." International Journal of Colorectal Disease 23, no. 7 (2008): 715–16. http://dx.doi.org/10.1007/s00384-008-0462-8.

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Thorpe, Ryan B., Anna Gray, Kirthi R. Kumar, Joseph S. Susa, and Benjamin F. Chong. "Site-Specific Analysis of Inflammatory Markers in Discoid Lupus Erythematosus Skin." Scientific World Journal 2014 (2014): 1–12. http://dx.doi.org/10.1155/2014/925805.

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Prior studies identified T cells, B cells, and macrophages in the inflammatory infiltrate and up-regulation of their protein products in discoid lupus erythematosus (DLE) skin; however, they lacked rigorous analyses to define their specific locations in skin. Thus, we compared expressions of selected T cell, B cell, and macrophage markers in five areas of DLE, psoriasis, and normal skin. Immunostainings for CD3, CD4, CD8, CD20, CD68, CXCR3, CXCL10, and TIA-1 were performed in biopsies of 23 DLE lesional skin, 11 psoriasis lesional skin, and 5 normal skin. Three independent observers used a gra

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Alharbi, Samar, and Jorge Sanchez-Guerrero. "Successful Treatment of Urticarial Vasculitis in a Patient With Systemic Lupus Erythematosus With Rituximab." Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders 13 (January 2020): 117954412096737. http://dx.doi.org/10.1177/1179544120967374.

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Urticarial vasculitis is an eruption of erythematous wheals that clinically resemble urticaria but histologically show changes of leukocytoklastic vasculitis. In association with connective tissue disease it is most commonly seen complicating Systemic lupus erythematous (SLE) and, less often, Sjogren’s syndrome. Here, we report a 25-year-old woman who developed SLE in 1998. In May 2013 she presented with urticarial vasculitis; her skin biopsy was consistent with leukocytoclastic vasculitis. She also developed bilateral uveitis. She had most of the clinical and laboratory characteristics of hyp

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Joseph, Adrienne K., Brandon Windsor, Linda S. Hynan, and Benjamin F. Chong. "Discoid lupus erythematosus skin lesion distribution and characteristics in Black patients: a retrospective cohort study." Lupus Science & Medicine 8, no. 1 (2021): e000514. http://dx.doi.org/10.1136/lupus-2021-000514.

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ObjectiveEpidemiological studies have shown that discoid lupus erythematosus (DLE) has a higher incidence and prevalence in racial/ethnic minority groups, particularly Black individuals. The objective of this retrospective cohort study was to identify the differences in DLE lesion distribution and characteristics in Black individuals compared with non-Black individuals.Methods183 patients with DLE (112 Black patients and 71 non-Black patients) with a reported race/ethnicity and Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) scores were included in this retrospective coho

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S. P., Gayathre, Niranjan Kumar, and Tharani Rajeswaran. "Cutaneous squamous cell carcinoma in a disseminated discoid lupus erythematosus lesion." International Surgery Journal 10, no. 3 (2023): 497–500. http://dx.doi.org/10.18203/2349-2902.isj20230506.

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The incidence of skin cancers is low in India when compared to the western world. Malignant transformation of discoid lupus erythematosus (DLE) is a rare entity. Most common site is head and neck. Our case reported is a disseminated DLE with malignant transformation to squamous cell carcinoma (SCC) of a lesion over arm with axillary node involvement. We proceeded with wide local excision and axillary node dissection.

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Griffies, Joel D., Colleen L. Mendelsohn, Wayne S. Rosenkrantz, Rusty Muse, Mona J. Boord, and Craig E. Griffin. "Topical 0.1% Tacrolimus for the Treatment of Discoid Lupus Erythematosus and Pemphigus Erythematosus in Dogs." Journal of the American Animal Hospital Association 40, no. 1 (2004): 29–41. http://dx.doi.org/10.5326/0400029.

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Topical 0.1% tacrolimus was used for treatment of localized lesions associated with 10 cases of discoid lupus erythematosus (DLE) and two cases of pemphigus erythematosus (PE) either as a sole therapy (n=2) or as an adjunctive treatment (n=10). Eight of 10 dogs with DLE and both dogs with PE were improved following 8 weeks of topical application. In six of the eight dogs that improved, other medications were discontinued. No adverse effects in clinical or laboratory parameters were noted throughout the study.

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Karki, S., and A. K. Jha. "DLE Progressing to Squamous Cell Carcinoma: A Case Report." Nepal Journal of Dermatology, Venereology & Leprology 14, no. 1 (2016): 51–55. http://dx.doi.org/10.3126/njdvl.v14i1.15839.

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A 90 years female diagnosed as a case of Discoid lupus erythematosus (DLE) developed Squamous cell carcinoma from the lesions over a period of 5 years due to treatment gap and late follow up. Diagnosis was based on clinical aspects (erythematous, nodular and scanty bleeding), dermoscopic features and histopathological examination, the absence of systemic involvement and routine laboratory parameters, which registered all within normal range.SCC in a patient with DLE is rare in Nepalese patients. It is every essential to counsel the diagnosed cases of DLE and warn all patients about all the pos

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Király, Zsófia, Eszter Nagy, Laura Bokor, Anikó Kovács, Márta Marschalkó, and Bernadett Hidvégi. "The Possible Clinical Significance of a Decreased Serum Level of Soluble PD-L1 in Discoid Lupus Erythematosus, but Not in Subacute Cutaneous Lupus Erythematosus—A Pilot Study." Journal of Clinical Medicine 12, no. 17 (2023): 5648. http://dx.doi.org/10.3390/jcm12175648.

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Cutaneous lupus erythematosus (CLE) is an autoimmune skin disease with various clinical forms, including the subtypes of discoid lupus erythematosus (DLE) and subacute cutaneous lupus erythematosus (SCLE). The altered function of the programmed cell death 1/programmed cell death ligand 1 (PD-1/PD-L1) axis in CLE pathogenesis has been suggested. Here, the soluble forms of PD-1 (sPD-1) and PD-L1 (sPD-L1) were explored in untreated DLE and SCLE. Levels of sPD-1 and sPD-L1 were determined by enzyme-linked immunosorbent assay in serums of 21 DLE, 18 SCLE, 13 systemic lupus erythematosus (SLE) patie

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Chandra, Mahesh. "A Systemic Review of Lupus Erythematosus autoimmune disease Classification, Pathogenesis, and Diagnosis." Clinical Research and Studies 3, no. 4 (2024): 01–08. https://doi.org/10.31579/2835-2882/062.

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Lupus is a systemic chronic inflammatory autoimmune disease that can present with a wide range of clinical symptoms. The four main types of lupus are neonatal and paediatric lupus erythematosus (NLE), drug induced lupus (DIL), discoid lupus erythematosus (DLE) and systemic lupus erythematosus (SLE). Due to aberrant immunological function and the generation of autoantibodies, which result in the development of immune complexes that may negatively impact healthy tissue, patients with lupus have a loss of self-tolerance. Immune abnormalities, environmental, hormonal, and genetic variables have be

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Isenberg, D., C. Dudeney, F. Wojnaruska, et al. "Detection of cross reactive anti-DNA antibody idiotypes on tissue-bound immunoglobulins from skin biopsies of lupus patients." Journal of Immunology 135, no. 1 (1985): 261–64. http://dx.doi.org/10.4049/jimmunol.135.1.261.

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Abstract Cross-reactive anti-DNA antibody idiotypes have been identified on tissue-bound immunoglobulins from skin biopsies of patients with systemic lupus erythematosus (SLE) and discoid lupus erythematosus (DLE). Four polyclonal and two monoclonal anti-idiotypic reagents were used to screen biopsies from 24 patients with SLE, 23 patients with DLE, and 15 other patients with IgM-positive skin biopsies. Up to 46% of the SLE patients and 30% of the DLE patients were found to share idiotypes present on immunoglobulins deposited at the dermal-epidermal junction. Inhibition studies in four patient

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Berthier, Celine C., Lam C. Tsoi, Tamra J. Reed, et al. "Molecular Profiling of Cutaneous Lupus Lesions Identifies Subgroups Distinct from Clinical Phenotypes." Journal of Clinical Medicine 8, no. 8 (2019): 1244. http://dx.doi.org/10.3390/jcm8081244.

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Cutaneous lupus erythematosus (CLE) is a common manifestation of systemic lupus erythematosus (SLE), and CLE can also develop without systemic involvement. CLE can be difficult to treat and negatively contributes to quality of life. Despite the importance of CLE, our knowledge of what differentiates cutaneous lupus subtypes is limited. Here, we utilized a large cohort of 90 CLE lesional biopsies to compare discoid lupus erythematosus (DLE) and subacute cutaneous lupus (SCLE) in patients with and without associated SLE in order to discern the drivers of disease activity and possibly uncover bet

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Domingo, Sandra, Cristina Solé, Teresa Moliné, Berta Ferrer, Josep Ordi-Ros, and Josefina Cortés-Hernández. "Efficacy of Thalidomide in Discoid Lupus Erythematosus: Insights into the Molecular Mechanisms." Dermatology 236, no. 5 (2020): 467–76. http://dx.doi.org/10.1159/000508672.

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Background: Thalidomide has been used successfully in a variety of chronic refractory inflammatory dermatological conditions with underlying autoimmune or infectious pathogenesis. It was first used for refractory discoid lupus erythematosus (DLE) in 1983 and has steadily grown since then. Method: In this review, we describe the therapeutic benefits of thalidomide for DLE treatment and its biological properties. We explain how new discoveries in DLE pathogenesis are relevant to understand thalidomide’s mechanism of action and the need to find an alternative safe drug with similar therapeutic ef

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Patel, Saloni, and Jun Kang. "TIME OF ONSET OF DISCOID LUPUS ERYTHEMATOSUS IMPACTS DISEASE OUTCOMES IN SYSTEMIC LUPUS ERYTHEMATOSUS: A LARGE-SCALE, PROPENSITY-MATCHED RETROSPECTIVE COHORT STUDY." Journal of Rheumatology 52, Suppl 1 (2025): 116.2–117. https://doi.org/10.3899/jrheum.2025-0390.pv064.

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PV064 / #310Poster Topic:AS07 - Cutaneous LupusBackground/PurposeDiscoid lupus erythematosus (DLE) is the most common form of chronic cutaneous lupus erythematosus, and up to 25% of patients with systemic lupus erythematosus (SLE) develop DLE lesions during their disease course. Prior research has suggested that the presence of DLE may modify the risk of disease complications, such as lupus nephritis and serositis, in patients with SLE, however, no studies have assessed the impact of time of onset of DLE on SLE outcomes. To address this gap, we investigated the impact of DLE incidence across 3

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Pradhan, P., S. Samal, and M. Sable. "Basal cell carcinoma arising over lesion of discoid lupus erythematosus: a rare occurrence." Lupus 29, no. 2 (2019): 210–12. http://dx.doi.org/10.1177/0961203319894371.

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Although the association of discoid lupus erythematosus (DLE) with squamous cell carcinoma has been described in the literature, coexistence with a basal cell carcinoma is very rare. The indolent and non-pruritic nature of the lesion cause it often to be diagnosed at the late stage of the disease. Long-standing photosensitivity and chronic inflammation later lead to scarring and hypopigmentation, which are considered as the risk factors for the malignant changes over DLE. Incisional biopsy is often performed from the erythematosus lesion which does not respond to medical treatment. Here we hav

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Khadatkar, Ashwini S., and Nishant B. Ghodake. "Trichoscopic findings in cicatricial alopecias and hair shaft disorders and its application in histopathology." International Journal of Research in Medical Sciences 5, no. 12 (2017): 5254. http://dx.doi.org/10.18203/2320-6012.ijrms20175435.

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Background: Many studies have been published on dermoscopy of hair and scalp disorders in the past few years, but these have been mainly carried out in western countries. Indian skin is mainly type IV and V and has its own unique set of problems and pathological findings. Hence, we conducted a study at our institute to study the dermoscopic patterns of various cicatricial alopecias.Methods: This was a descriptive study conducted in the Dermatology outpatient department, Skinaccess clinics, Nashik, between August 2014 to June 2016. The most common and characteristic feature seen in patients wit

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Jin, Hui, Shihang Zhou, Yangyiyi Yu, et al. "Panoramic view of clinical features of lupus erythematosus: a cross-sectional multicentre study from China." Lupus Science & Medicine 10, no. 1 (2023): e000819. http://dx.doi.org/10.1136/lupus-2022-000819.

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ObjectiveLupus erythematosus (LE) is a complicated disease with highly heterogeneous clinical manifestations. Previous studies have rarely included all subgroups of patients with lupus and have overlooked the importance of the cutaneous manifestations thereof. We aimed to compare the demographic and clinical differences among patients with different subtypes of lupus.MethodsThis is the first real-world study with a relatively large sample size that simultaneously includes patients with isolated cutaneous lupus erythematosus (iCLE) and SLE. All samples were obtained from the Lupus Erythematosus

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Mozgovaya, E. E., S. A. Bedina, A. S. Trofimenko, S. S. Spitsina, M. A. Mamus, and I. A. Zborovskaya. "Comparative characteristics of blood xanthine oxidoreductase profiles in discoid and systemic lupus erythematosus." Сибирский научный медицинский журнал 43, no. 6 (2024): 155–63. http://dx.doi.org/10.18699/ssmj20230619.

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Discoid (DLE) and systemic lupus erythematosus (SLE) are chronic inflammatory diseases of the connective tissue. Along with pathogenetic features, they have common characteristics. Immune disorders and oxidative stress are involved in pathogenesis of DLE and SLE. Development of oxidative stress is closely associated with the activation of xanthine oxidoreductase (XOR) enzyme system.Aim of the study was to reveal the features of XOR activities profiles in blood of DLE and systemic lupus erythematosus (SLE) patients.Material and methods. 31 patients with DLE, 56 patients with SLE, 35 apparently

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N, Habib. "Review Article: Systemic Lupus Erythematosus." Open Access Journal of Microbiology & Biotechnology 5, no. 1 (2020): 1–4. http://dx.doi.org/10.23880/oajmb-16000158.

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Systemic lupus erythematosus or SLE is a persistent heterogeneous autoimmune disease that affects multisystem of the body. It is distinguished by acute and chronic inflammation of various tissues and even organs of the body principally the skin and joints. Systemic lupus erythematosus is a multisystem disorder and hence, it can affect any tissues, organs and even systems of the body. There are few categories of lupus for instance, lupus dermatitis or cutaneous lupus erythematosus (CLE) that affects the skin and causes malar rash, discoid lupus erythematosus (DLE) as well as systemic lupus eryt

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Méndez-Flores, Silvia, Gabriela Hernández-Molina, Ana Bety Enríquez, et al. "Cytokines and Effector/Regulatory Cells Characterization in the Physiopathology of Cutaneous Lupus Erythematous: A Cross-Sectional Study." Mediators of Inflammation 2016 (2016): 1–15. http://dx.doi.org/10.1155/2016/7074829.

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We compared the presence of diverse cytokines and regulatory T and B cells in skin biopsies of discoid lupus erythematosus (DLE) and subacute cutaneous lupus erythematosus (SCLE). We included 19 patients with DLE, 13 with SCLE, 8 healthy controls, and 5 patients with hypertrophic scars. We assessed the CLASI activity score. To determine IL-22-producing cells and the subpopulation of CD4+/IL-17A+-, CD4+/IL-4+-, and CD4+/IFN-γ+-expressing T cells, CD123+/IDO+pDCs, CD25+/Foxp3+Tregs, and CD20+/IL-10+-producing B cells, an immunostaining procedure was performed. Also intracellular IL-22, IL-17, IL

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Shapera, Emanuel A., and Paul D. Kim. "Squamous Cell Cancer Arising in an African American Male Cheek from Discoid Lupus: A Rare Case and Review of the Literature." Case Reports in Surgery 2016 (2016): 1–3. http://dx.doi.org/10.1155/2016/9170424.

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A 50-year-old African American male with Discoid Lupus Erythematosus (DLE) presented to the dermatology clinic for a rapidly enlarging left cheek mass. The mass failed to resolve with conservative measures. A biopsy revealed poorly differentiated Squamous Cell Carcinoma (SCC). He was referred to Head and Neck Surgery and successfully underwent a resection with free flap reconstruction. Postoperatively he did well. Squamous cell skin carcinomas arising from lesions of Discoid Lupus are rare and aggressive tumors with greater likelihood of metastases. Cases have been reported among patients with

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