Academic literature on the topic 'Discoidin domain receptor'

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Journal articles on the topic "Discoidin domain receptor"

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Song, Sunmi, Nicholas A. Shackel, Xin M. Wang, Katerina Ajami, Geoffrey W. McCaughan, and Mark D. Gorrell. "Discoidin Domain Receptor 1." American Journal of Pathology 178, no. 3 (2011): 1134–44. http://dx.doi.org/10.1016/j.ajpath.2010.11.068.

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BADIOLA, Iker. "Discoidin Domain Receptors Role in Human Diseases." Notulae Scientia Biologicae 3, no. 4 (2011): 07–12. http://dx.doi.org/10.15835/nsb346455.

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Discoidin Domain Receptor 1 and Discodin Domain Receptor 2 are the two only members of the DDR family. The DDR family is a Tyrosine Kinase Receptor (TKR) family with some peculiarities compared with other Tyrosine Kinase Receptors such as their natural ligand; which in this case is the fibrillar collagen; or the slow phosphorylation pattern. These peculiarities confer a special role to the receptors present in many diseases development processes as cancer, cirrhosis or lung fibrosis. In this review it is described the overview of the DDRs structure and their role in the different disease devel
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Vogel, Wolfgang F. "Ligand-induced shedding of discoidin domain receptor 1." FEBS Letters 514, no. 2-3 (2002): 175–80. http://dx.doi.org/10.1016/s0014-5793(02)02360-8.

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Fu, Hsueh-Liang, Rajeshwari R. Valiathan, Richard Arkwright, et al. "Discoidin Domain Receptors: Unique Receptor Tyrosine Kinases in Collagen-mediated Signaling." Journal of Biological Chemistry 288, no. 11 (2013): 7430–37. http://dx.doi.org/10.1074/jbc.r112.444158.

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Zhu, Aiyu, Yuting Liu, and Xiangan Lin. "Roles of discoidin domain receptor 1 in gastrointestinal tumors." Digestive Medicine Research 2 (July 2019): 13. http://dx.doi.org/10.21037/dmr.2019.06.01.

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Chua, Huey-Huey, Te-Huei Yeh, Ying-Piao Wang, et al. "Upregulation of discoidin domain receptor 2 in nasopharyngeal carcinoma." Head & Neck 30, no. 4 (2008): 427–36. http://dx.doi.org/10.1002/hed.20724.

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Vogel, Wolfgang, Cord Brakebusch, Reinhard Fässler, Frauke Alves, Florence Ruggiero та Tony Pawson. "Discoidin Domain Receptor 1 Is Activated Independently of β1Integrin". Journal of Biological Chemistry 275, № 8 (2000): 5779–84. http://dx.doi.org/10.1074/jbc.275.8.5779.

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Coelho, Nuno M., Pamma D. Arora, Sander van Putten, et al. "Discoidin Domain Receptor 1 Mediates Myosin-Dependent Collagen Contraction." Cell Reports 18, no. 7 (2017): 1774–90. http://dx.doi.org/10.1016/j.celrep.2017.01.061.

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Schmoker, Anna M., Alicia M. Ebert, and Bryan A. Ballif. "The DCBLD receptor family: emerging signaling roles in development, homeostasis and disease." Biochemical Journal 476, no. 6 (2019): 931–50. http://dx.doi.org/10.1042/bcj20190022.

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Abstract The discoidin, CUB, and LCCL domain-containing (DCBLD) receptor family are composed of the type-I transmembrane proteins DCBLD1 and DCBLD2 (also ESDN and CLCP1). These proteins are highly conserved across vertebrates and possess similar domain structure to that of neuropilins, which act as critical co-receptors in developmental processes. Although DCBLD1 remains largely uncharacterized, the functional and mechanistic roles of DCBLD2 are emerging. This review provides a comprehensive discussion of this presumed receptor family, ranging from structural and signaling aspects to their ass
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Abbonante, Vittorio, Cristian Gruppi, Diana Rubel, Oliver Gross, Remigio Moratti, and Alessandra Balduini. "Discoidin Domain Receptor 1 Protein Is a Novel Modulator of Megakaryocyte-Collagen Interactions." Journal of Biological Chemistry 288, no. 23 (2013): 16738–46. http://dx.doi.org/10.1074/jbc.m112.431528.

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Growing evidence demonstrates that extracellular matrices regulate many aspects of megakaryocyte (MK) development; however, among the different extracellular matrix receptors, integrin α2β1 and glycoprotein VI are the only collagen receptors studied in platelets and MKs. In this study, we demonstrate the expression of the novel collagen receptor discoidin domain receptor 1 (DDR1) by human MKs at both mRNA and protein levels and provide evidence of DDR1 involvement in the regulation of MK motility on type I collagen through a mechanism based on the activity of SHP1 phosphatase and spleen tyrosi
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Dissertations / Theses on the topic "Discoidin domain receptor"

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Yeung, David Alexander. "Oligomeric Status of Discoidin Domain Receptor Modulates Collagen Binding, Mechanics, and Receptor Phosphorylation." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1524185313118309.

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Roberts, Mark E. "The role of Discoidin Domain Receptor 1 in bronchial epithelial repair." Thesis, University of Nottingham, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555506.

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The factors contributing to epithelial repair are not well understood. Epithelial injury leads to cell loss and exposure of the basement membrane, followed by secretion of provisional matrix (composed of collagens) and migration of epithelial cells to close the wound. The molecular processes involved are not well characterized, although growth factors such as EGF have been implicated. This work shows that the collagen I receptor Discoidin Domain Receptor 1 (DDR1) facilitates epithelial repair. Using a wounding model in BEAS-2B cells, DDRl knockdown inhibits epithelial repair while DDRi overexp
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Nauerth, Michelle Jon. "Role of the Discoidin Domain receptor proteins in atherosclerosis: Interaction with lipids and collagen." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1316545109.

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Margielewska, Sandra Karolina. "The contribution of discoidin domain receptor 1 to the pathogenesis of diffuse large B cell lymphoma." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8421/.

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Collagen is the ligand for the discoidin domain receptor-1 (DDR1), a receptor tyrosine kinase that is over-expressed in Hodgkin lymphoma. However, the role of DDR1 in diffuse large B cell lymphoma (DLBCL) is not known. I showed that DDR1 is over-expressed in a subset of DLBCL where it positively correlates with expression of its collagen ligands, and negatively correlates with expression of mitotic spindle genes. DDR1 correlated genes also overlapped with three aneuploidy signatures and DDR1 expression correlated significantly with autosomal aneuploidy index. RNAseq analysis revealed that over
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Klapproth, Erik [Verfasser], Nils [Gutachter] Cordes, and Achim [Gutachter] Temme. "Discoidin Domain Receptor 1 critically regulates GBM cell survival and invasion / Erik Klapproth ; Gutachter: Nils Cordes, Achim Temme." Dresden : Technische Universität Dresden, 2018. http://d-nb.info/1227196601/34.

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Khosravi, Roozbeh. "Glycation of collagen interferes with discoidin domain receptor 2 (DDR2) mediated collagen induction of lysyl oxidase in osteoblasts." Thesis, Boston University, 2013. https://hdl.handle.net/2144/11104.

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Thesis (Ph.D.)--Boston University<br>Diabetes doubles the risk of bone fracture. Poor quality of bone in diabetes is largely linked to diminished bone formation and bone organic phase abnormalities. Studies indicated that in diabetes, glycation of type I collagen, the most abundant protein in bone extracellular matrix, prompts abnormal arrangement of collagen molecules leading to weak bones. In addition, diabetic bone fragility is attributed to reduced levels of lysyl oxidase enzyme-dependent collagen cross-links. However, the mechanism underlying the presence of lower levels of enzymatic coll
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Sivakumar, Lalitha. "Effect of DDR2 on Rheology of Collagen type I Fibers." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1243537065.

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Tonniges, Jeffrey R. "Regulation of Collagen Fibril Structure and Function by DDR1 in the Murine Aorta." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1471373750.

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Dorison, Aude. "Le récepteur à domaine discoïdine de type 1 : un acteur majeur des pathologies rénales chroniques et aiguës." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066144/document.

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Les maladies rénales ont un impact socio-économique majeur sur la santé publique nécessitant le développement de nouvelles stratégies thérapeutiques. Le Récepteur à Domaine Discoïdine de type 1 (DDR1) est un récepteur non-intégrine des collagènes, à activité tyrosine-kinase. Son expression anormale est un facteur clé de la pathologie rénale qui promeut le développement de l’inflammation et de la fibrose.Ces travaux de thèse nous ont permis de démontrer que l'inhibition de DDR1 freinait la progression des maladies rénales dans trois modèles, dont l'un d'évolution aiguë, l'ischémie-reperfusion (
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Farzadi, Arghavan. "Effect of Discoidin Domain Receptors on Biomimetic Matrix Mineralization." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1563447989534881.

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Books on the topic "Discoidin domain receptor"

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Fridman, Rafael, and Paul H. Huang, eds. Discoidin Domain Receptors in Health and Disease. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6383-6.

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Abdulhussein, Rahim. Exploring collagen interactions and activation modes of discoidin domain receptor 1. 2005.

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Koo, Diana Hung-Hung. The role of discoidin domain receptor 1 in maintaining E-cadherin-mediated cell-cell contacts in the mammary gland. 2007.

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Fridman, Rafael, and Paul H. Huang. Discoidin Domain Receptors in Health and Disease. Springer, 2018.

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Fridman, Rafael, and Paul H. Huang. Discoidin Domain Receptors in Health and Disease. Springer, 2016.

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Book chapters on the topic "Discoidin domain receptor"

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Iwai, Leo K., Leo S. Payne, Dina Allam, and Paul H. Huang. "Discoidin Domain Receptor Signalling Networks." In Discoidin Domain Receptors in Health and Disease. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6383-6_11.

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Ruiz-Castro, Pedro A., Duncan Shaw, and Gabor Jarai. "Discoidin Domain Receptor Signaling and Pharmacological Inhibitors." In Discoidin Domain Receptors in Health and Disease. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6383-6_12.

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Xu, Lin, Peter L. Lee, and Yefu Li. "Discoidin Domain Receptor 2 in Development of Osteoarthritis." In Discoidin Domain Receptors in Health and Disease. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6383-6_14.

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Unsoeld, Thomas, Jesse Taylor, and Harald Hutter. "Discoidin Domain Receptors in Invertebrates." In Discoidin Domain Receptors in Health and Disease. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6383-6_5.

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Longmore, Gregory D., and Whitney R. Grither. "Discoidin Domain Receptors and Disease." In Discoidin Domain Receptors in Health and Disease. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6383-6_6.

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Olaso, Elvira, Joana Marquez, Aitor Benedicto, Iker Badiola, and Beatriz Arteta. "Discoidin Domain Receptors in Liver Fibrosis." In Discoidin Domain Receptors in Health and Disease. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6383-6_16.

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Justus, David E., Adam Hoffman, Ekaterina Mironova, et al. "Discoidin Domain Receptors in Cardiac Development." In Discoidin Domain Receptors in Health and Disease. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6383-6_18.

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Zhang, Yingtao, Agnes Malysa, and Gerold Bepler. "Discoidin Domain Receptors in Lung Cancer." In Discoidin Domain Receptors in Health and Disease. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6383-6_8.

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Leitinger, Birgit. "DDRs: Binding Properties, Cell Adhesion and Modulation of Integrin Function." In Discoidin Domain Receptors in Health and Disease. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6383-6_1.

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Lu, Xiaoyun, and Ke Ding. "Small Molecule Inhibitors of Discoidin Domain Receptors (DDRs)." In Discoidin Domain Receptors in Health and Disease. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6383-6_10.

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Conference papers on the topic "Discoidin domain receptor"

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Valiathan, Rajeshwari R., Kathy A. Toy, Ajay Gopalakrishna, Fred R. Miller, Celina G. Kleer, and Rafael A. Fridman. "Abstract LB-18: Expression of discoidin domain receptor tyrosine kinases in breast cancer." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-lb-18.

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Zhang, Kun, Callie Corsa, Julie Prior, David Piwnica-Worms, and Gregory D. Longmore. "Abstract 3939: The collagen receptor discoidin domain receptor 2 facilitates breast cancer metastasis by stabilizing Snail1 protein." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-3939.

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Rudra-Ganguly, Nandini, Daulet Satpayev, Christine Lowe, et al. "Abstract 1086: Discoidin domain receptor 1 contributes to tumorigenesis through modulation of TGFBI expression." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-1086.

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Hur, Hoon, In-hye Ham, Da Keun Lee, et al. "Abstract B14: Discoidin domain receptor 1 activity drives an aggressive phenotype in gastric adenocarcinoma." In Abstracts: AACR Special Conference: The Function of Tumor Microenvironment in Cancer Progression; January 7-10, 2016; San Diego, CA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.tme16-b14.

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Gupta, K., B. Yuan, and R. Li. "Abstract P4-03-05: Role of stromal discoidin domain receptor-1 in breast cancer." In Abstracts: 2016 San Antonio Breast Cancer Symposium; December 6-10, 2016; San Antonio, Texas. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.sabcs16-p4-03-05.

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Bonfil, R. Daniel, Anjum Sohail, Semir Vranić, et al. "Abstract 1070: Discoidin domain receptor 1 (DDR1): A potential suppressor of prostate cancer progression." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-1070.

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Yuge, Ryo, Yasuhiko Kitadai, Kei Shinagawa, et al. "Abstract 5070: Inhibition of collagen receptor discoidin domain receptor-1 (DDR1) reduces colon cancer cell migration and metastasis." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-5070.

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Yuge, Ryo, Yasuhiko Kitadai, Hidehiko Takigawa, Shinji Tanaka, Kazuaki Chayama, and Wataru Yasui. "Abstract 1987: Inhibition of collagen receptor discoidin domain receptor-1 (DDR1) reduces gastric cancer cell motility and metastasis." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-1987.

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Ali-Rahmani, Fatima, David Fitzgerald, Scott Martin, Paresma Patel, Craig Thomas, and Ira Pastan. "Abstract 5428: Inhibition of collagen receptor discoidin domain receptor-1 (DDR1) tyrosine kinase enhances cytotoxicity of anti-mesothelin immunotoxin." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-5428.

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Morcavallo, Alaide, Simone Buraschi, Shi-Qiong Xu, et al. "Abstract 4415: Discoidin domain receptor 1 (DDR1) and IGF-I system crosstalk in bladder cancer progression." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-4415.

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Reports on the topic "Discoidin domain receptor"

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Hammerman, Peter. Characterization of the Discoidin Domain Receptor 2 Kinase as a Novel Therapeutic Target for Squamous Cell Lung Cancer. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada573105.

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