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Dissertations / Theses on the topic 'Discoidin domain receptor'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 February 2022

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1

Yeung, David Alexander. "Oligomeric Status of Discoidin Domain Receptor Modulates Collagen Binding, Mechanics, and Receptor Phosphorylation." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1524185313118309.

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2

Roberts, Mark E. "The role of Discoidin Domain Receptor 1 in bronchial epithelial repair." Thesis, University of Nottingham, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555506.

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The factors contributing to epithelial repair are not well understood. Epithelial injury leads to cell loss and exposure of the basement membrane, followed by secretion of provisional matrix (composed of collagens) and migration of epithelial cells to close the wound. The molecular processes involved are not well characterized, although growth factors such as EGF have been implicated. This work shows that the collagen I receptor Discoidin Domain Receptor 1 (DDR1) facilitates epithelial repair. Using a wounding model in BEAS-2B cells, DDRl knockdown inhibits epithelial repair while DDRi overexp

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3

Nauerth, Michelle Jon. "Role of the Discoidin Domain receptor proteins in atherosclerosis: Interaction with lipids and collagen." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1316545109.

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4

Margielewska, Sandra Karolina. "The contribution of discoidin domain receptor 1 to the pathogenesis of diffuse large B cell lymphoma." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8421/.

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Collagen is the ligand for the discoidin domain receptor-1 (DDR1), a receptor tyrosine kinase that is over-expressed in Hodgkin lymphoma. However, the role of DDR1 in diffuse large B cell lymphoma (DLBCL) is not known. I showed that DDR1 is over-expressed in a subset of DLBCL where it positively correlates with expression of its collagen ligands, and negatively correlates with expression of mitotic spindle genes. DDR1 correlated genes also overlapped with three aneuploidy signatures and DDR1 expression correlated significantly with autosomal aneuploidy index. RNAseq analysis revealed that over

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5

Klapproth, Erik [Verfasser], Nils [Gutachter] Cordes, and Achim [Gutachter] Temme. "Discoidin Domain Receptor 1 critically regulates GBM cell survival and invasion / Erik Klapproth ; Gutachter: Nils Cordes, Achim Temme." Dresden : Technische Universität Dresden, 2018. http://d-nb.info/1227196601/34.

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6

Khosravi, Roozbeh. "Glycation of collagen interferes with discoidin domain receptor 2 (DDR2) mediated collagen induction of lysyl oxidase in osteoblasts." Thesis, Boston University, 2013. https://hdl.handle.net/2144/11104.

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Thesis (Ph.D.)--Boston University<br>Diabetes doubles the risk of bone fracture. Poor quality of bone in diabetes is largely linked to diminished bone formation and bone organic phase abnormalities. Studies indicated that in diabetes, glycation of type I collagen, the most abundant protein in bone extracellular matrix, prompts abnormal arrangement of collagen molecules leading to weak bones. In addition, diabetic bone fragility is attributed to reduced levels of lysyl oxidase enzyme-dependent collagen cross-links. However, the mechanism underlying the presence of lower levels of enzymatic coll

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7

Sivakumar, Lalitha. "Effect of DDR2 on Rheology of Collagen type I Fibers." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1243537065.

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8

Tonniges, Jeffrey R. "Regulation of Collagen Fibril Structure and Function by DDR1 in the Murine Aorta." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1471373750.

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9

Dorison, Aude. "Le récepteur à domaine discoïdine de type 1 : un acteur majeur des pathologies rénales chroniques et aiguës." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066144/document.

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Les maladies rénales ont un impact socio-économique majeur sur la santé publique nécessitant le développement de nouvelles stratégies thérapeutiques. Le Récepteur à Domaine Discoïdine de type 1 (DDR1) est un récepteur non-intégrine des collagènes, à activité tyrosine-kinase. Son expression anormale est un facteur clé de la pathologie rénale qui promeut le développement de l’inflammation et de la fibrose.Ces travaux de thèse nous ont permis de démontrer que l'inhibition de DDR1 freinait la progression des maladies rénales dans trois modèles, dont l'un d'évolution aiguë, l'ischémie-reperfusion (

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10

Farzadi, Arghavan. "Effect of Discoidin Domain Receptors on Biomimetic Matrix Mineralization." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1563447989534881.

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11

Noordeen, Nafeesa Alibhai. "Investigating the structural domains required for activation of the human discoidin domain receptors, DDR1 and DDR2." Thesis, University College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435070.

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12

Sala, Margaux. "Implication des récepteurs à domaine discoïdine dans la résistance à la thérapie ciblée au cours du mélanome." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0400.

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La combinaison de deux traitements, un anti-BRAF et un anti-MEK est actuellement utilisée en première ligne de traitement dans la prise en charge des patients ayant un mélanome métastatique porteur de la mutation somatique BRAF V600E. Cependant, le problème majeur dans le mélanome est l'acquisition d'une résistance cellulaire chez 80% des patients, qui est associée à une augmentation de la formation de métastases, notamment due à l'hyper-activation de la voie des MAP kinases. Or, les récepteurs à domaine discoïdine DDR1 et DDR2 sont capables d’activer cette voie de signalisation. Les DDRs sont

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13

Mihai, Cosmin. "Role of oligomerization in discoidin domain receptors collagen type I interaction /." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1213203191.

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14

Zurakowski, Honorata. "Expression of discoidin domain receptors in 3T3-L1 preadipocytes and adipocytes." Thesis, University of Ottawa (Canada), 2006. http://hdl.handle.net/10393/27207.

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Discoidin domain receptors (DDRs) are receptor tyrosine kinases, of which there are members, DDR1 and DDR2, which are activated by collagen and are involved in cellular proliferation. Therefore, given their role in extracellular matrix interactions and proliferation, both of which affect adipogenesis, we hypothesized that the DDRs influence preadipocyte biology, adipogenesis and adipocyte biology. DDR1 protein expression was decreased in 3T3-L1 a dipocytes versus preadipocytes, whereas, DDR1 mRNA expression was decreased at day 4 of 3T3-L1 adipogenesis compared to day 0. DDR2 mRNA expression w

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15

Blissett, Angela Rae. "Regulation of Extracellular Matrix Remodeling and Bone Morphology by Discoidin Domain Receptors." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1305900854.

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16

Roig, Bourgine Bàrbara. "Expressió del receptor domini discoidina 1 (DDR1) en cervell huma. Relació amb l'esquizofrènia." Doctoral thesis, Universitat Rovira i Virgili, 2007. http://hdl.handle.net/10803/8860.

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L'esquizofrènia és una de les psicosis més comunes que té una prevalença d'un 1% en la població mundial i una etiologia desconeguda. Una de les hipòtesis etiopatològiques més recolzades per l'esquizofrènia és la teoria del neurodesenvolupament la qual postula que l'origen de la esquizofrènia tindria lloc per alteracions de la neurogènesi i gliogènesi en les etapes del desenvolupament perinatal. Nombrosos estudis han descrit diverses alteracions de la mielina (substància blanca del cervell) en pacients esquizofrènics. La mielinització dels axons és important per una correcta transmissió del sen

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17

Rahnema, Nazanine. "Expression of the discoidin domain receptors, DDR-1 and DDR-2 in human normal and osteoarthritic articular cartilages." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=29469.

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Osteoarthritis (OA) is a degenerative, age related disease of diarthrodial joints. In OA, there is increased cleavage of type II collagen by collagenases in articular cartilage. This excessive cleavage can be caused by the altered feedback regulation of gene expression in chondrocytes by collagen type II or its degradation products which may serve as regulators of collagenase synthesis and activity through a cell surface receptor-mediated mechanism. The aim of the present study was to investigate the expression and production of collagen receptors, DDR-1 and DDR-2 in human adult normal and OA

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18

Virgos, Matilla Carmen. "Anàlisi mutacional i estudi d'associació del gen receptor domini discoidina 1 (ddr1) en l'esquizofrènia." Doctoral thesis, Universitat Rovira i Virgili, 2004. http://hdl.handle.net/10803/8728.

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Aquest treball té com a objectiu l'anàlisi de l'associació de variants genètiques en el gen receptor domini discoidina 1 (DDR1) en l'esquizofrènia i de les eines necessàries per la identificació i genotipació d'SNPs.<br/>En el primer estudi, es va realitzar una anàlisi mutacional per seqüenciació de pools de mostres de DNA de malalts d'esquizofrènia de les regions exòniques i exó-intró de DDR1. Es van identificar 17 variants: 16 SNPs i una deleció de 2 pb.<br/>En el segon estudi, es va dur a terme un estudi d'associació d'haplotips i de desequilibri de lligament (LD) per anàlisi de 5 SNPs en l

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19

Tomàs, Roig Jordi. "Contribució del receptor domini discoidina 1 (ddr1) en el procés de mielinització. Aplicació de diferents models experimentals." Doctoral thesis, Universitat Rovira i Virgili, 2010. http://hdl.handle.net/10803/8887.

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S'ha demostrat que la mielina està alterada en el cervell de pacients amb esquizofrènia. El gen domini discoidina 1 (DDR1), que s'expressa en mielina, s'ha trobat associat a esquizofrènia. Ambdues troballes fetes al grup de recerca on he desenvolupat el treball de tesi doctoral.<br/><br/>· Contribucions i coneixements nous que aporta la tesi<br/>En síntesi podem afirmar que DDR1 és clau en el procés de mielinització. Una regulació a la baixa d'aquest gen podria estar associat a malalties de mielina.<br/><br/>Estudi1.Caracterització conductual durant el segon període de remielinització de rato

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20

Manning, Lauren Brooke. "Experimental Evaluation of Discoid Domain Receptor 2 as an Ideal Target for Development of Disease-Modifying Osteoarthritis Drugs." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17331959.

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Abstract: Osteoarthritis (OA) affects 250 million people worldwide. Currently, no targets for disease-modifying osteoarthritis drugs exist. Matrix metalloproteinase-13 (MMP-13) would make it an ideal target; however, its broad biological effects restrict its application as a target enzyme of inhibitory drugs in the treatment of OA. The expression and activation of discoidin domain receptor 2 (DDR2) is increased in human OA tissues and mouse models of OA and was co-localized with elevated expression of MMP-13 in degenerative articular cartilages. In healthy articular cartilage, DDR2 is kept

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21

Wan, Mark H. "The Mechanism of Discoidin Domain Receptor 1 Mediated Vascular Calcification." Thesis, 2013. http://hdl.handle.net/1807/35146.

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Introduction: Activation of Runt Related Transcription Factor 2 (RUNX2) is required for transdifferentiation of Vascular Smooth Muscle Cells (VSMCs) into a calcifying osteoblast-like phenotype. Our lab showed that deletion of Discoidin Domain Receptor 1 (Ddr1), decreased atherosclerotic vascular calcification in the Ldlr-/- mouse. Hypothesis: DDR1 regulates RUNX2 activity by affecting microtubule organization during VSMC mediated calcification. Results: Ddr1-/- VSMCs show reduced RUNX2 activity when compared to Ddr1+/+ VSMCs. Addition of the microtubule-destabilizing agent nocodazole inhib

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22

Abdulhussein, Rahim. "Exploring collagen interactions and activation modes of discoidin domain receptor 1." 2005. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=370333&T=F.

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23

Klapproth, Erik. "Discoidin Domain Receptor 1 critically regulates GBM cell survival and invasion." Doctoral thesis, 2018. https://tud.qucosa.de/id/qucosa%3A32278.

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Background: Glioblastomas (GBM) are characterised by genetic and epigenetic alterations in resistance-mediating genes and destructive infiltration of the surrounding normal brain. Cell adhesion molecules play an important role for intrinsic and acquired therapy resistances. Among the group of adhesion molecules, the collagen-binding discoidin domain receptor 1 (DDR1) is considered as potential, druggabale and promising cancer target owing to its own tyrosine kinase activity and its overexpression in various cancer types. This study evaluates the so far unknown role of DDR1 in GBM invasion and

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24

Staudinger, Lisa Alexandra. "Functional Interactions between the Discoidin Domain Receptor 1 and Beta 1 Integrins." Thesis, 2013. http://hdl.handle.net/1807/35138.

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The rate limiting step of phagocytosis is the binding of collagen to specific receptors, which include β1 integrins and the discoidin domain receptor 1 (DDR1). While these two receptors may interact, the functional nature of these interactions is not defined. We examined the effects of DDR1 over-expression on β1 integrin function and determined that DDR1 over-expression enhanced cell attachment through β1 integrins. These data are consistent with data showing that DDR1 over-expression enhanced cell-surface, but not total, β1 integrin expression and activation. As shown by experiments with endo

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25

Britto, Karen Elma. "The Role of Discoidin Domain Receptor 1 (Ddr1) on Macrophages in Adhesion and Cytokine Production." Thesis, 2010. http://hdl.handle.net/1807/25438.

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Atherosclerosis is an inflammatory disease of the cardiovascular system. Discoidin domain receptor 1 is a receptor tyrosine kinase that binds collagens. Previous work in our lab has shown that deleting DDR1 in a mouse model results in attenuation of atherosclerosis, with fewer macrophages in the plaque. The aim of this study was to determine what changes in macrophage behaviour due to the lack of DDR1 was attenuating plaque development. In order to carry out experiments, primary mouse peritoneal macrophages were used. DDR1-deficient macrophages adhered significantly less to type IV coll

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26

Wang, Chau-Zen, and 王昭仁. "Functional studies of collagen receptor Discoidin domain receptor I in cell migration and hepatocyte growth factor-induced branching tubulogenesis." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/42220082855596704272.

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博士<br>國立成功大學<br>基礎醫學研究所<br>94<br>Branching tubulogenesis is an important feature of many organs during embryonic development. Madin-Darby canine kidney (MDCK) cells develop branching tubules in three-dimensional collagen gel in the induction of hepatocyte growth factor (HGF). Discoidin domain receptor I (DDR1) is a receptor tyrosine kinase and serves as the receptor for collagen in addition to integrins. MDCK cells normally express DDR1. However, the function of DDR1 in this in vitro model system has not been understood. To dissect the function of DDR1, we established stable-transfected MDCK c

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27

Yi-ChunYeh та 葉儀君. "A Tale of Two Collagen Receptors in Epithelial Cell Differentiation: β1 integrin or Discoidin Domain Receptor 1, that is the question". Thesis, 2010. http://ndltd.ncl.edu.tw/handle/78662387891239357505.

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博士<br>國立成功大學<br>基礎醫學研究所<br>99<br>Collagen is the most abundant extracellular matrix in mamalian body. There are two main types of collagen receptors, integrins and discoidin domain receptors (DDRs). Research works conducted in the last decade have lead to remarkable understanding of their functions in cell proliferation, extension, and migration. However, less was known about their functions in cell differentiation, particularly in epithelium. Therefore, the purpose of this thesis was to examine their functions and signal mechanism involved in epithelial cell differentiation. The first part

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28

Yeh, Yi-June, and 葉儀君. "Discoidin domain receptor 1 inhibits collagen-induced cell spreading via suppression of Cdc42 activation mediated by a2b1 integrin." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/45338242530504156353.

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碩士<br>國立成功大學<br>生理學研究所<br>93<br>Discoidin domain receptor (DDR) is a receptor tyrosine kinase for collagen. We previously showed that over-expression of DDR1 in MDCK cells prevented cell spreading, whereas dominant negative DDR1 induced cell spreading on collagen gel-coated dish. Cell spreading is an important characteristic for cell migration, but the mechanism whereby DDR1-inhibited cell spreading is still unidentified. Cell spreading involves organization of actin cytoskeleton, which is mainly regulated by Rho family-GTPases. In order to examine whether Rho family-GTPases are involved in co

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29

Koo, Diana Hung-Hung. "The role of discoidin domain receptor 1 in maintaining E-cadherin-mediated cell-cell contacts in the mammary gland." 2007. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=452872&T=F.

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30

Franco, Christopher. "A Functional Role for Doscoidin Domain Receptor 1 (Ddr1) in the Regulation of Inflmmation and Fibrosis During Atherosclerotic Plaque Development." Thesis, 2009. http://hdl.handle.net/1807/17761.

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Collagens are abundant components of the extracellular matrix in the atherosclerotic plaque. In addition to contributing to lesion volume and mechanical stability, collagens can influence the behavior of macrophages and smooth muscle cells (SMCs) and have profound effects on both inflammation and fibrosis during lesion development. The aim of this thesis was to define a functional role for the discoidin domain receptor 1 (DDR1), a collagen receptor tyrosine kinase, in murine models of atherogenesis. In our first study, using Ddr1+/+;Ldlr-/- and Ddr1-/-;Ldlr-/- mice fed a high fat diet,

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31

Baronsky, Thilo. "Cellular locomotion and adhesion in the context of different substrate properties." Doctoral thesis, 2016. http://hdl.handle.net/11858/00-1735-0000-002B-7D16-B.

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32

Hung, Yung-Li, and 洪永豊. "The Role of Discoidin Domain Receptors in Chondrogenesis of Human Adipose Derived Mesenchymal Stem Cells." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/78431421275610933230.

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碩士<br>高雄醫學大學<br>生理及分子醫學研究所<br>97<br>Recent years, it has already become a critical topic in the developed country that the articular cartilage traumas result in the cartilage degeneration or osteoarthritis, especially in the population of old age and contingency. In Taiwan, osteoarthritis has occupies the seventh place of chronic disease in old man. Articular cartilage lacks the stem cells and the blood flow supplied, which do increased difficulty in the cartilage self-repairing from the body. At present, it still lacks effective treatment or medicine to heal the articular cartilage disease. O

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