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Journal articles on the topic 'Discordant colour'

Author: Grafiati

Published: 4 June 2021

Last updated: 13 February 2022

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1

Mancuso, Patrizia, Elisabetta Muratori, Cristina Rabascio, Angelica Calleri, Chiara Corsini, and Francesco Bertolini. "Lymphoma Cell Detection and Follow-Up in the Rituximab Era: Concordance between Flow Cytometry, Qualitative/Quantitative PCR and FISH in the Marrow and Blood from 647 Patients." Blood 104, no. 11 (November 16, 2004): 1376. http://dx.doi.org/10.1182/blood.v104.11.1376.1376.

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Abstract The anti-CD20 monoclonal antibody Rituximab is now widely used in B-cell non-Hodgkin’s lymphoma (NHL) and chronic lymphocytic leukemia (CLL) patients. Its administration is associated with a profound reduction of the number of normal and malignant CD20+ B cells, so that the procedures used so far for NHL and CLL diagnosis, detection of minimal residual disease (MRD) and follow-up (F-UP) should be revised. We have retrospectively evaluated our consecutive 4-year record of 647 NHL and CLL patients. Our aims were: 1) to compare sensitivity and concordance between 4-colour flow cytometry,

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Mano, Pavan. "Disarming as a tactic of resistance in Pink Dot." Pink Dot 10, no. 2 (July 16, 2021): 129–56. http://dx.doi.org/10.1075/jls.20008.man.

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Abstract Pink Dot is an annual rally in support of LGBT (lesbian, gay, bisexual, and transgender) people in Singapore. In a country where many prefer to avoid overt displays of dissent, Pink Dot has gained significant popular support. In this article, I explore how it has done so. Through a close multimodal analysis focusing on the use of colour, layout, and typography in a Pink Dot 2017 flyer, I demonstrate how these features work together in the Singaporean context to realize meanings of positivity, warmth, and inclusivity whilst simultaneously de-emphasizing notions of claiming rights. I ar

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Beck, O., M. Kraft, M. R. Moeller, B. L. Smith, S. Schneider, and R. Wennig. "Frontline ® immunochromatographic device for on-site urine testing of amphetamines: laboratory validation using authentic specimens." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 37, no. 2 (March 1, 2000): 199–204. http://dx.doi.org/10.1258/0004563001899005.

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We evaluated a new test device for amphetamines and methamphetamines (Frontline ®, cut-off limit 300 ng/mL) using authentic clinical and forensic specimens. The device is based on immunochromatography and is dipped into urine and read visually by comparison with a colour scale after a few minutes. A total of 658 specimens were tested by comparing results of the screening procedure with established immunoassays. Discordant results were further investigated by gas chromatography- mass spectrometry or gas chromatography (with flame ionization detector). The Frontline device had a sensitivity of 9

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Kröber, Alexander, Dirk Kienle, Dirk Winkler, Andreas Bühler, Till Seiler, Christine Schöpflin, Sabrina Kless, Claire Paulus, Hartmut Döhner, and Stephan Stilgenbauer. "ZAP-70 Expression, VH-Mutation Status, Genomic Aberrations and Prognosis in Chronic Lymphocytic Leukemia." Blood 104, no. 11 (November 16, 2004): 1920. http://dx.doi.org/10.1182/blood.v104.11.1920.1920.

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Abstract The VH status is a strong prognostic marker in chronic lymphocytic leukemia (CLL). ZAP-70, a zeta associated tyrosine kinase physiologically expressed by T-cells, is overexpressed in VH unmutated CLL and could therefore serve as a surrogate marker for the VH status. We analyzed ZAP-70 expression (n=96), the VH status (n=75) and genomic aberrations (n=84) in a single center CLL cohort to study associations among these parameters and to assess their relative prognostic value. ZAP-70 expression was measured by 4-colour flow cytometry (CD5, CD19, CD3/56, ZAP-70) applying an unconjugated a

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Kumar, Ishan, Shivi Jain Shivi Jain, Ashish Verma, Madhu Jain Madhu Jain, Ram C. Shukla, and Arvind Srivastava. "Discordant Twin Pregnancy with One Malformed Fetus – Color Doppler Follow Up for Expectant Management." Indian Journal of Applied Research 3, no. 9 (October 1, 2011): 469–72. http://dx.doi.org/10.15373/2249555x/sept2013/142.

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Phipps, J. B. "Introduction to the red-fruited hawthorns (Crataegus, Rosaceae) of western North America." Canadian Journal of Botany 76, no. 11 (November 1, 1998): 1863–99. http://dx.doi.org/10.1139/b98-148.

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Howell's failure in 1898 to typify Crataegus columbiana Howell (the species is based on noncited discordant paratype elements) and the readiness of later authors to make new varieties in this species without resolving the type problem has been the cause of much confusion in the nomenclature of the western red-fruited hawthorns. This has been increased by the failure to recognize Crataegus williamsii Eggl. and compounded by almost a century of no revisionary study on western Crataegus with the further result that boundaries between taxa have been routinely misunderstood outside Colorado. In pur

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Gircys, Michael, and Brian J. Ross. "Image Evolution Using 2D Power Spectra." Complexity 2019 (January 2, 2019): 1–21. http://dx.doi.org/10.1155/2019/7293193.

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Procedurally generated images and textures have been widely explored in evolutionary art. One active research direction in the field is the discovery of suitable heuristics for measuring perceived characteristics of evolved images. This is important in order to help influence the nature of evolved images and thereby evolve more meaningful and pleasing art. In this regard, particular challenges exist for quantifying aspects of style and shape. In an attempt to bridge the divide between computer vision and cognitive perception, we propose the use of measures related to image spatial frequencies.

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Eyskens, Benedicte, Frank Weidemann, Miroslaw Kowalski, Jan Bogaert, Steven Dymarkowski, Bart Bijnens, Marc Gewillig, George Sutherland, and Luc Mertens. "Regional right and left ventricular function after the Senning operation: an ultrasonic study of strain rate and strain." Cardiology in the Young 14, no. 3 (June 2004): 255–64. http://dx.doi.org/10.1017/s1047951104003038.

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Background:Systemic right ventricular dysfunction is a major concern in the follow-up of patients who underwent an atrial redirection procedure for transposition (concordant atrio-ventricular and discordant ventriculo-arterial connections). No good non-invasive method is currently available for quantifying right ventricular function.Aims:We have used ultrasonically based imaging of strain rate and strain to quantify regional deformation in the right ventricle after the Senning operation, comparing properties of regional deformation of the right ventricle with right ventricular ejection fractio

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Norrsell, Ulf. "Color Vision and Frithiof Holmgren's Discordant Retinal Microstimulation Findings." Journal of the History of the Neurosciences 19, no. 3 (July 9, 2010): 228–38. http://dx.doi.org/10.1080/09647040902997721.

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Elisa de Villemor-Amaral, Anna, Giselle Pianowski, and Lucas de Francisco Carvalho. "Issues About Color, Human Movement, and Number of Responses in the Zulliger Test." Rorschachiana 37, no. 2 (September 2016): 95–113. http://dx.doi.org/10.1027/1192-5604/a000068.

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Abstract. This study aimed to verify the scope and limitations of the stimuli of indicators of Color (C), Human movement (M), and Response number (R) of the Zulliger test through a qualitative analysis of the stimuli present in the Zulliger and the Rorschach, comparisons in expressions of C, M, and R, and R relations with evaluative inconsistencies on Zulliger. Taking the Rorschach as a reference, the qualitative analysis indicated a variation from little equivalence up to an overrepresentativeness of Zulliger stimuli. The comparisons, made with a sample of 51 subjects tested with the Zulliger

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Akın, Çiğdem, C. Can Bilgin, and Metin Bilgin. "Discordance between ventral colour and mtDNA haplotype in the water frog Rana (ridibunda) caralitana, 1988 Arıkan." Amphibia-Reptilia 31, no. 1 (2010): 9–20. http://dx.doi.org/10.1163/156853810790457867.

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AbstractThe water frog form caralitana was first described as a subspecies of Rana ridibunda by Arıkan (1988) from southwestern Turkey. Its orange ventral colour has been used as a diagnostic character since its description. After testing for a correlation between body size and ventral colour, we compared mtDNA and venter colour of adult specimens from 27 localities to assess the validity of this character for systematics of Anatolian water frogs. We mapped the distribution of each category and tested whether there is concordance between mtDNA haplotype and ventral colour of sampled individual

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Martín Moro, Fernando, Miguel Piris-Villaespesa, Monica Garcia Cosio, Jesus Villarrubia, Juan Marquet Palomanes, Ana Lario Arribas, Eulalia Rodríguez Martín, et al. "Diffuse Large B-Cell Lymphoma, Not Otherwise Specified: Discordance between Histology and Flow Cytometry in Bone Marrow Examination at Diagnosis." Blood 132, Supplement 1 (November 29, 2018): 1718. http://dx.doi.org/10.1182/blood-2018-99-117041.

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Abstract Background: Bone marrow (BM) examination is essential in the staging of diffuse large B-cell lymphoma (DLBCL). The assessment of BM involvement includes both histology (gold-standard) and flow cytometry (FC), but few studies have compared BM biopsy (BMB) histologic findings with results of FC analysis of BM aspirate. Discordance between both techniques generates debate about the staging and the prognostic significance in these cases. Methods: We performed a retrospective single-center analysis of patients with DLBCL, not otherwise specified (NOS) diagnosed during a 4-year period (2014

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Gladman, Gordon, Frank Casey, and Ian Adatia. "Supravalvar stenosing tricuspid ring in congenitally corrected transposition." Cardiology in the Young 6, no. 2 (April 1996): 174–76. http://dx.doi.org/10.1017/s1047951100003553.

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SummaryWe report an unusual case with discordant atrioventricular and ventriculoarterial connections. In addition to the commonly associated intracardiac anomalies ofventricular septal defect and subpulmonary tissue tags, a supravalvar ring was present above the left-sided, morphologically tricuspid valve. This case highlights the value of color flow Doppler echocardiography in making the diagnosis, particularly as the supravalvar ring was seen poorly angiographically.

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Sonneveld, Edwin, Christian M. Zwaan, Alita J. van der Sluijs-Gelling, Valerie de Haas, Rob Pieters, and Vincent H. J. van der Velden. "Immunophenotyping Versus Morphological Evaluation Of Fresh and Stabilized Cerebrospinal Fluid As Diagnostic Tool For CNS Involvement In Childhood Acute Lymphoblastic Leukemia." Blood 122, no. 21 (November 15, 2013): 4950. http://dx.doi.org/10.1182/blood.v122.21.4950.4950.

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Abstract Introduction Presence of malignant cells in cerebrospinal fluid (CSF) is a risk factor in pediatric acute lymphoblastic leukemia (ALL). Consequently, these patients receive extra intrathecal treatment. We evaluated the concordance between morphological and flow-cytometric (FCM) results, both on freshly analyzed and on stabilized, overnight transported samples. Methods Diagnostic CSF samples of 61 newly diagnosed pediatric ALL patients were divided in two aliquots. One was sent to the local laboratory and processed within a few hours after sampling (lab1). A second aliquot was 1:1 dilu

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den Braber, Anouk, Dennis van ‘t Ent, Danielle C. Cath, Dick J. Veltman, Dorret I. Boomsma, and Eco J. C. de Geus. "Brain Activation During Response Interference in Twins Discordant or Concordant for Obsessive Compulsive Symptoms." Twin Research and Human Genetics 15, no. 3 (June 2012): 372–83. http://dx.doi.org/10.1017/thg.2012.2.

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One of the core behavioral features associated with obsessive compulsive symptomatology is the inability to inhibit thoughts and/or behaviors. Neuroimaging studies have indicated abnormalities in frontostriatal and dorsolateral prefrontal – anterior cingulate circuits during inhibitory control in patients with obsessive compulsive disorder compared with controls. In the present study, task performance and brain activation during Stroop color-word and Flanker interference were compared within monozygotic twin pairs discordant for obsessive compulsive symptoms and between groups of pairs scoring

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Mori, Kazuhiro, Masafumi Harada, and Yasuhiro Kuroda. "Twisted atrioventricular valves in double inlet left ventricle." Cardiology in the Young 12, no. 4 (July 2002): 401–3. http://dx.doi.org/10.1017/s1047951100013032.

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AbstractTwisted atrioventricular connections usually occur in hearts with biventricular artioventricular connections. Here, we describe a case of twisted atrioventricular valves associated with double inlet left ventricle and discordant ventriculo-arterial connections. Color Doppler echocardiography, and cine magnetic resonance imaging, clearly demonstrated that the right atrioventricular valve was located anterior and superior to the left atrioventricular valve, and that the axes of the two atrioventricular valves crossed each other within the dominant left ventricle.

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Carnicer, Maria-Jose, Frederik W. van Delft, Lyndal Kearney, and Mel Greaves. "Sub-Clonal Genetic Heterogeneity in BCR-ABL1 Positive Acute Lymphoblastic Leukaemia." Blood 118, no. 21 (November 18, 2011): 1348. http://dx.doi.org/10.1182/blood.v118.21.1348.1348.

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Abstract Abstract 1348 Philadelphia-positive (Ph+) acute lymphoblastic leukaemia (ALL), characterised by the BCR-ABL1 fusion gene, occurs in approximately 30% of adult and 5% of childhood ALL and is associated with a poor prognosis. It is considered a single clinical entity with identifiable and recurrent copy number alterations (CNA); notably deletions of the lymphoid transcriptional regulator IKAROS (encoded by IKZF1), PAX5, and CDKN2A/B that are presumed to cooperate with BCR–ABL 1 in lymphoid leukaemogenesis. In particular, IKZF1 deletions are present in 80% of BCR-ABL1 positive ALL cases,

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Gerber, Amanda, Lisa Koenig, Lori Millner, Lindsay Strotman, Valeria Sero, Nicolò Manaresi, Sabine Kasimir-Bauer, and Farideh Z. Bischoff. "Inter-laboratory evaluation of a novel DEPArray-HER2 FISH assay." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): e12506-e12506. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e12506.

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e12506 Background: Fluorescent in Situ Hybridization (FISH) is a method currently used for detection and assessment of HER2 gene amplification. Although clinical guidelines set forth by CAP/ASCO exist to ensure accuracy, limitations in HER2test results due to sample preparation, assay-conditions and tumor heterogeneity remain unresolved. We have successfully demonstrated analytical confidence in performing HER2 FISH on DEPArray™ sorted and recovered tumor cells. In this study, we aimed to evaluate inter-laboratory concordance of the DEPArray™ HER2-FISH assay. Methods: Three laboratories equipp

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Wedger, Marshall J., Tonapha Pusadee, Anupong Wongtamee, and Kenneth M. Olsen. "Discordant Patterns of Introgression Suggest Historical Gene Flow into Thai Weedy Rice from Domesticated and Wild Relatives." Journal of Heredity 110, no. 5 (May 7, 2019): 601–9. http://dx.doi.org/10.1093/jhered/esz030.

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Abstract Weedy relatives of crop species infest agricultural fields worldwide, reducing harvests and threatening global food security. These weeds can potentially evolve and adapt through gene flow from both domesticated crop varieties and reproductively compatible wild relatives. We studied populations of weedy rice in Thailand to investigate the role of introgression from cultivated and wild rice in their evolution. We examined 2 complementary sources of genetic data: allelic variation at 3 rice domestication genes (Bh4, controlling hull color; Rc, controlling pericarp color and seed dormanc

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Faron, Matthew L., Blake W. Buchan, Christopher Coon, Theo Liebregts, Anita van Bree, Arjan R. Jansz, Genevieve Soucy, John Korver, and Nathan A. Ledeboer. "Automatic Digital Analysis of Chromogenic Media for Vancomycin-Resistant-Enterococcus Screens Using Copan WASPLab." Journal of Clinical Microbiology 54, no. 10 (July 13, 2016): 2464–69. http://dx.doi.org/10.1128/jcm.01040-16.

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Vancomycin-resistant enterococci (VRE) are an important cause of health care-acquired infections (HAIs). Studies have shown that active surveillance of high-risk patients for VRE colonization can aid in reducing HAIs; however, these screens generate a significant cost to the laboratory and health care system. Digital imaging capable of differentiating negative and “nonnegative” chromogenic agar can reduce the labor cost of these screens and potentially improve patient care. In this study, we evaluated the performance of the WASPLab Chromogenic Detection Module (CDM) (Copan, Brescia, Italy) sof

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Gumusay, Ozge, Mustafa Benekli, Ozgur Ekinci, Meltem Baykara, Ahmet Ozet, Ugur Coskun, Aytug Uner, Ayse Dursun, Ecine Yesim Atak, and Suleyman Buyukberber. "Discordances in HER2 status between primary gastric cancer and corresponding metastatic sites." Journal of Clinical Oncology 33, no. 3_suppl (January 20, 2015): 25. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.25.

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25 Background: Determination of HER2 status in advanced gastric cancer (GC) is important in clinical decision making. In the ToGA trial, trastuzumab based therapy demonstrated a significant OS benefit in patients with HER2 positive advanced GC. HER2 discordance in GC primary and its metastases has been long debated. The aim of the study was to evaluate the rate of HER2 discordance and its effect on treatment decisions in advanced GC. Methods: A total of 74 patients with advanced GC were included in the study. Both immunohistochemical staining (IHC) and dual-color silver in situ hybridization (

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Koperski, Paweł, Rafał Milanowski, and Agnieszka Krzyk. "Searching for cryptic species in Erpobdella octoculata (L.) (Hirudinea: Clitellata): discordance between the results of genetic analysis and cross-breeding experiments." Contributions to Zoology 80, no. 1 (February 21, 2011): 85–94. http://dx.doi.org/10.1163/18759866-08001004.

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The main aim of this study was to reveal reproduction barriers and potentially cryptic radiation within the very common and morphologically variable leech species - Erpobdella octoculata (L., 1758). The differences in reproductive success of the morphological forms were compared experimentally. The data based on the results of field sampling and analysis of ITS and COI sequences is also presented. The results of the analysis of DNA sequences clearly show lack of reproduction barriers between the analysed morphological forms. Subtle differences in DNA sequences between individuals, found with t

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OHMER, MICHEL E., JEANNE M. ROBERTSON, and KELLY R. ZAMUDIO. "Discordance in body size, colour pattern, and advertisement call across genetically distinct populations in a Neotropical anuran (Dendropsophus ebraccatus)." Biological Journal of the Linnean Society 97, no. 2 (May 26, 2009): 298–313. http://dx.doi.org/10.1111/j.1095-8312.2009.01210.x.

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Pedicelli, A., C. Distasi, C. Settecasi, G. M. Dilella, C. Colosimo, and M. Rollo. "Studio Eco-Color-Doppler transcranico (ECD TC) degli aneurismi cerebrali." Rivista di Neuroradiologia 13, no. 2 (April 2000): 191–96. http://dx.doi.org/10.1177/197140090001300205.

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Verificare le possibilità dell'ECD-TC nella valutazione degli aneurismi cerebrali, a confronto con i dati ottenuti con l'angiografia. Sono stati studiati 12 pazienti con aneurisma cerebrale a distanza di 1–8 giorni da emorragia subaracnoidea. Lo studio è stato condotto in color-doppler, in power-doppler ed in 2 casi anche con mdc ecografico, impiegando sonda transcranica settoriale da 2,5 MHz; la diagnosi era già stata ottenuta con angiografia selettiva. In tutti i pazienti si è ottenuta una soddisfacente visualizzazione dell'aneurisma e dei suoi rapporti con l'arteria parente. I dati dimensio

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Burke, P. H. "Intrapair Facial Differences in Twins." Acta geneticae medicae et gemellologiae: twin research 38, no. 1-2 (April 1989): 37–47. http://dx.doi.org/10.1017/s0001566000002816.

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AbstractAnnual serial records in the form of facial contour maps were examined for 18 like-sexed twin pairs of near equal zygosity distribution. Zygosity diagnosis was based primarily on hematological reports for 26 of the 36 children and the remainder were diagnosed on a basis of the concordance or discordance of various physical characteristics: standing height, finger print ridge count, tooth size, and hair and eye colour. Thirteen facial parameters were measured on 274 maps. After age correcting and theree-point smoothing, more than 1,150 intrapair differences of individual facial paramete

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de Tute, Ruth M., Sharon Barrans, Andy C. Rawstron, Peter W. M. Johnson, Andrew J. Davies, and Andrew Jack. "Patients With DLBCL Commonly Have B-Cell Lymphopenia and Circulating Clonal B-Cell Populations With a Phenotype Concordant With The Underlying Tumour." Blood 122, no. 21 (November 15, 2013): 3013. http://dx.doi.org/10.1182/blood.v122.21.3013.3013.

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Abstract Clonal B-cell populations with either a CLL or a non-CLL phenotype are a common finding in normal individuals but uncertainty remains about how this relates to the development of clinically significant disease. The aim of this study was to investigate the frequency of peripheral blood clonal B-cell populations and B-cell subset abnormalities in newly presenting DLBCL patients and to determine whether the incidence of these abnormalities differed between the GCB and ABC subtypes, which are regarded as having distinct pathogenesis. The study was carried out using peripheral blood sample

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Singh, Sumit Randhir, Alexandre Matet, Elon H. C. van Dijk, Alejandra Daruich, Sascha Fauser, Suzanne Yzer, Enrico Peiretti, et al. "Discrepancy in current central serous chorioretinopathy classification." British Journal of Ophthalmology 103, no. 6 (July 12, 2018): 737–42. http://dx.doi.org/10.1136/bjophthalmol-2018-312435.

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AimTo report the discordance in central serous chorioretinopathy (CSCR) classification among practising retina specialists.MethodsThe study conducted was a multicentre survey. Multimodal retinal images along with relevant clinical details of 100 cases diagnosed as CSCR (from six centres) were circulated among six retina specialists across the globe. The image sets included colour fundus photographs, fundus autofluorescence images, optical coherence tomography b-scans, fluorescein and indocyanine green angiography of the study and fellow eyes. The graders were asked to classify the disease of s

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Slack, John F., and Paul R. Coad. "Multiple hydrothermal and metamorphic events in the Kidd Creek volcanogenic massive sulphide deposit, Timmins, Ontario: evidence from tourmalines and chlorites." Canadian Journal of Earth Sciences 26, no. 4 (April 1, 1989): 694–715. http://dx.doi.org/10.1139/e89-059.

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Tourmaline and chlorite are the principal ferromagnesian silicate minerals in the Kidd Creek massive sulphide deposit. Tourmaline is most common in sphalerite-rich peripheral margins of the chalcopyrite stringer zone. Within the north orebody, samples typically contain <1% tourmaline, but small areas (hand-specimen scale) may have 10–20%. Chlorite is more widely distributed and in places constitutes 30–50% of rock volumes. Associated assemblages may include quartz, sulphides (principally chalcopyrite, sphalerite, and (or) pyrite), carbonate, albite, sericite, and rare fluorite, allanite, or

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Shichishima, T., T. Terasawa, C. Hashimoto, H. Ohto, M. Takahashi, A. Shibata, and Y. Maruyama. "Discordant and heterogeneous expression of GPI-anchored membrane proteins on leukemic cells in a patient with paroxysmal nocturnal hemoglobinuria." Blood 81, no. 7 (April 1, 1993): 1855–62. http://dx.doi.org/10.1182/blood.v81.7.1855.1855.

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Abstract We performed a flow cytometric analysis using monoclonal antibodies to decay accelerating factor (DAF) and CD59/membrane attack complex inhibitory factor (CD59/MACIF) in order to investigate the leukemic cells and erythrocytes from a patient with paroxysmal nocturnal hemoglobinuria (PNH) who developed acute myelocytic leukemia. In May 1990, the leukemic cells comprised 70% of the mononuclear cells in the bone marrow and 76% of those in the peripheral blood. They consisted of a mixture of positive and negative populations, including single DAF- positive cells. In August 1990, almost 10

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Shichishima, T., T. Terasawa, C. Hashimoto, H. Ohto, M. Takahashi, A. Shibata, and Y. Maruyama. "Discordant and heterogeneous expression of GPI-anchored membrane proteins on leukemic cells in a patient with paroxysmal nocturnal hemoglobinuria." Blood 81, no. 7 (April 1, 1993): 1855–62. http://dx.doi.org/10.1182/blood.v81.7.1855.bloodjournal8171855.

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We performed a flow cytometric analysis using monoclonal antibodies to decay accelerating factor (DAF) and CD59/membrane attack complex inhibitory factor (CD59/MACIF) in order to investigate the leukemic cells and erythrocytes from a patient with paroxysmal nocturnal hemoglobinuria (PNH) who developed acute myelocytic leukemia. In May 1990, the leukemic cells comprised 70% of the mononuclear cells in the bone marrow and 76% of those in the peripheral blood. They consisted of a mixture of positive and negative populations, including single DAF- positive cells. In August 1990, almost 100% of the

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Todorovic, Dejan. "Constancies and illusions in visual perception." Psihologija 35, no. 3-4 (2002): 125–207. http://dx.doi.org/10.2298/psi0203125t.

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This paper presents a systematic exposition of the general structure of visual constancies and illusions, including the introduction of a number of conceptual distinctions, illustrated by many examples. The study of these phenomena involves the distal, the proximal, and the phenomenal domain. The relations of concordance and discordance between pairs of domains are defined, followed by the definitions of four visual modes (concordant, proximal, constancy, illusion) as particular constellations of concordance-discordance relations between all three domains. Constancies and illusions are charact

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Mullen, Sean P., Nicholas W. VanKuren, Wei Zhang, Sumitha Nallu, Evan B. Kristiansen, Qiqige Wuyun, Kevin Liu, Ryan I. Hill, Adriana D. Briscoe, and Marcus R. Kronforst. "Disentangling Population History and Character Evolution among Hybridizing Lineages." Molecular Biology and Evolution 37, no. 5 (January 13, 2020): 1295–305. http://dx.doi.org/10.1093/molbev/msaa004.

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Abstract Understanding the origin and maintenance of adaptive phenotypic novelty is a central goal of evolutionary biology. However, both hybridization and incomplete lineage sorting can lead to genealogical discordance between the regions of the genome underlying adaptive traits and the remainder of the genome, decoupling inferences about character evolution from population history. Here, to disentangle these effects, we investigated the evolutionary origins and maintenance of Batesian mimicry between North American admiral butterflies (Limenitis arthemis) and their chemically defended model

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Ebrashy, Alaa, Mona Aboulghar, Mohamed Elhodiby, Sara H. El-Dessouky, Sherif Elsirgany, Hassan M. Gaafar, Sahar S. Sheta, et al. "Fetal heart examination at the time of 13 weeks scan: a 5 years’ prospective study." Journal of Perinatal Medicine 47, no. 8 (October 25, 2019): 871–78. http://dx.doi.org/10.1515/jpm-2019-0222.

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Abstract Objective To evaluate our ability in classifying the fetal heart as normal or abnormal during the 1st trimester scan through fetal cardiac examination and determining the best time for this examination. Methods This was a prospective study performed on 3240 pregnant women to examine the fetal heart. Four chambers view and ventricular outflow tracts were mainly examined during the scan. We used grayscale and color mapping in the diagnosis. Color Doppler was used if additional information was needed, and all patients were rescanned during the 2nd trimester to confirm or negate our diagn

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Van Winden, Kristi R., Ruben A. Quintero, Eftichia V. Kontopoulos, Lisa M. Korst, Arlyn Llanes, and Ramen H. Chmait. "Pre-Operative Twin Anemia/Polycythemia in the Setting of Twin-Twin Transfusion Syndrome (TTTS)." Fetal Diagnosis and Therapy 37, no. 4 (2015): 274–80. http://dx.doi.org/10.1159/000365919.

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Introduction: Twin-twin transfusion syndrome (TTTS) and twin anemia-polycythemia sequence (TAPS) are classified as distinct clinical disorders associated with unbalanced blood flow through placental vascular communications. Typically, TAPS placentas demonstrate few <1 mm arteriovenous (AV) communications, and at fetoscopy the twins are visibly pale and plethoric. Materials and Methods: In a cohort of TTTS patients who underwent laser surgery, those with preoperative findings suggestive of anemia/polycythemia (AP) were compared to those with TTTS alone. AP was defined as middle cerebral arte

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Kumar, Manish, Kishore Kumar, Harinder Pal Singh, Suresh Nair, Amol Patel, Ashok Kumar, and Sneha Soni. "Discordance between Fluorescence In Situ Hybridization and Immunohistochemistry Analysis of Anaplastic Lymphoma Kinase Rearrangement in Indian Patients with Non-Small Cell Lung Cancer." South Asian Journal of Cancer 9, no. 02 (June 2020): 109–14. http://dx.doi.org/10.1055/s-0040-1721191.

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Abstract Aims This study aims to evaluate the incidence of anaplastic lymphoma kinase (ALK) mutation in nonsmall cell lung cancer (NSCLC) incorporating fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) methods and to look for any discordance. Methods We evaluated 101 samples obtained from an enriched cohort of NSCLCs patients from the Army Hospital Research and Referral, New Delhi, India, between November 2016 and November 2018. IHC was performed using the highly-sensitive D5F3 rabbit monoclonal primary antibody. FISH was performed with dual-color, break-apart probe (Zyt

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Eyding, Jens, Christos Krogias, Marcus Seemann, Ralf Gold, and Achim Mumme. "Review: Discordant findings in color-coded duplex-sonography and magnetic resonance angiography in symptomatic internal carotid artery stenosis: implications for diagnostic work-up and early intervention." Therapeutic Advances in Neurological Disorders 3, no. 1 (December 4, 2009): 69–71. http://dx.doi.org/10.1177/1756285609351763.

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Kawakami, Takeshi, Meghan K. Jensen, Andrea Slavney, Petra E. Deane, Ausra Milano, Vandana Raghavan, Brett Ford, Erin T. Chu, Aaron J. Sams, and Adam R. Boyko. "R-locus for roaned coat is associated with a tandem duplication in an intronic region of USH2A in dogs and also contributes to Dalmatian spotting." PLOS ONE 16, no. 3 (March 23, 2021): e0248233. http://dx.doi.org/10.1371/journal.pone.0248233.

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Structural variations (SVs) represent a large fraction of all genetic diversity, but how this genetic diversity is translated into phenotypic and organismal diversity is unclear. Explosive diversification of dog coat color and patterns after domestication can provide a unique opportunity to explore this question; however, the major obstacle is to efficiently collect a sufficient number of individuals with known phenotypes and genotypes of hundreds of thousands of markers. Using customer-provided information about coat color and patterns of dogs tested on a commercial canine genotyping platform

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Hertzberg, Lawrence, Karina Baggianni, Rosalba Tamayo, Patrick Browne, and Teri Oldaker. "A Comparison of Zap-70 by Immunohistochemistry and Flow Cytometry Using Two Different Flow Analysis Methods." Blood 106, no. 11 (November 16, 2005): 4994. http://dx.doi.org/10.1182/blood.v106.11.4994.4994.

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Abstract Zap-70 expression by flow cytometry has been shown to be a surrogate marker for un-mutated/germline IgH status in chronic lymphocytic leukemia (CLL).1 Reproducibility and confidence in the accuracy of results can make this assay problematic. We compared our current single-parameter/one-color, immunohistochemistry (IHC) Zap-70 assay with our flow cytometry Zap-70 assay. Twenty-one (21) patient samples submitted to our lab for Zap-70 testing were assayed by IHC and flow cytometry (FC). In addition, two FC analysis methods were used. One analysis method uses isotype controls to establish

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Carulli, Giovanni, Sara Galimberti, Giuseppina Bianchi, Alessandra Zucca, Enrico Orciuolo, Gabriele Buda, Giulia Cervetti, and Mario Petrini. "Comparison of Bone Marrow Biopsy, Flow Cytometry and PCR Assays To Detect Bone Marrow Involvement in B-Cell Non-Hodgkin Lymphomas." Blood 106, no. 11 (November 16, 2005): 4670. http://dx.doi.org/10.1182/blood.v106.11.4670.4670.

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Abstract Bone marrow biopsy, (BMB) is essential to detect bone marrow (BM) infiltration in B-cell non-Hodgkin lymphomas (NHLs). Flow cytometry (FC) and PCR for clonal IgH rearrangement are considered as ancillary methods, but there is increasing evidence for their clinical usefulness. Observations dealing with combined use of the three methods still are lacking. Thus we carried out a retrospective study about the usefulness of an integrated approach to detect BM infiltration in NHLs. 193 patients suffering from NHLs (79 at presentation, 114 after chemotherapy alone or with: Rituximab, Campath-

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Letestu, Remi, Guillaume Cartron, Stephane Lepretre, Magali Le Garff-Tavernier, Francoise Solly, Lydia Campos, Michel Ticchioni, et al. "Minimal Residual Disease (MRD) By 8-Color Flow Cytometry (Flow-MRD) and IGH Clonospecific Quantitative PCR (ASO RQPCR) Reached Similar Performances for Evaluation of CLL Treatment in a Phase II Clinical Trial: Cross Validation of the Methods." Blood 124, no. 21 (December 6, 2014): 3307. http://dx.doi.org/10.1182/blood.v124.21.3307.3307.

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Abstract Evaluation of MRD after treatment has an increasing importance in CLL treatment. Recent studies have demonstrated that patients achieving MRD below 10-4 have significantly longer OS and/or PFS compared to subjects with positive MRD (Böttcher, JCO 2012). Additionally, in CLL patients treated by FC(R)-based regimen, 4-color flow MRD was found as effective as ASO RQ PCR for MRD evaluation down to the level of 10-4, but below that level, PCR was more sensitive (Böttcher, Leukemia 2009). The aim of our study was to investigate the sensitivity of 8-color Flow-MRD and compare it to ASO RQPCR

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Hess, Allan D., Christian Meyer, Christopher Thoburn, Ferdynand Kos, Christopher Gocke, Hyam Levitsky, and Judith Karp. "Immune Recovery after Timed Sequential Therapy in Acute Myelogenous Leukemia: Discordant Recovery of Naïve T Lymphocytes and Antigen Driven Regulatory T Cells." Blood 112, no. 11 (November 16, 2008): 947. http://dx.doi.org/10.1182/blood.v112.11.947.947.

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Abstract Patients who demonstrate a rapid but limited initial lymphocyte recovery following therapy have a significantly better response rate than patients where lymphocyte recovery is markedly delayed. Timed sequential therapy (TST) is a cell cycle dependent based approach for curative therapeutic potential in acute myelogenous leukemia (AML). Recovery of T cells in this setting can be due to thymic dependent T cell development or as a consequence of directed (antigen) expansion of effector T lymphocytes. The present studies evaluated immunological reconstitution of 26 AML patients following

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Spencer, Andrew, Tiffany Khong, Flora Yuen, Hannah Victoria Giles, Malgorzata Gorniak, Hang Quach, Noemi Horvath, et al. "A Longitudinal Evaluation of Euroflow and Combined Quantitative Immunoprecipitation (QIP) and Free Light Chain (FLC) Mass Spectometry (MS) in Functional High Risk Multiple Myeloma." Blood 134, Supplement_1 (November 13, 2019): 3090. http://dx.doi.org/10.1182/blood-2019-129760.

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Introduction: The achievement of minimal residual disease (MRD) negativity is being increasingly recognised as the optimal measure of therapeutic response for both newly diagnosed and relapsed and/or refractory multiple myeloma (MM) patients. Bone marrow (BM) evaluation with either Next Generation Sequencing (NGS) or Next Generation Flow-cytometry (NGF) affords a high level of sensitivity and the attainment of MRD negativity (< 1 in 10-5 MM cells) with either approach is a powerful predictor of superior progression free survival (PFS). Both, however, are limited by the requirement for invas

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Al Harby, Lamis, Mandeep S. Sagoo, Roderick O’Day, Gordon Hay, Amit K. Arora, Pearse A. Keane, Victoria M. L. Cohen, and Bertil Damato. "Distinguishing Choroidal Nevi from Melanomas Using the MOLES Algorithm: Evaluation in an Ocular Nevus Clinic." Ocular Oncology and Pathology 7, no. 4 (2021): 294–302. http://dx.doi.org/10.1159/000511363.

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<b><i>Objective:</i></b> The aim of this study was to determine the sensitivity and specificity of the MOLES scoring system in differentiating choroidal melanomas from nevi according to Mushroom shape, Orange pigment, Large tumor size, Enlarging tumor, and Subretinal fluid (SRF). <b><i>Methods:</i></b> Color photographs, fundus-autofluorescence images, and optical coherence tomography of 222 melanocytic choroidal tumors were reviewed. Each MOLES feature was retrospectively scored between 0 and 2 and tumors categorized as “common nevus,” “low-risk

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Michallet, Mauricette, Colette Chapuis-Cellier, Christine Lombard, Mohamad Sobh, Thomas Dejoie, Helene Caillon, Michel Attal, Philippe Moreau, and Herve Avet-Loiseau. "Responses Assigned Using Heavy+Light Chain Assessments Have Better Clinical Correlation with Outcome Than Those Using Current IMWG Criteria for Multiple Myeloma." Blood 128, no. 22 (December 2, 2016): 3245. http://dx.doi.org/10.1182/blood.v128.22.3245.3245.

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Abstract Introduction: Stratification of multiple myeloma patient responses by reductions in monoclonal component is based upon reliable, historic outcome data. With the introduction of novel agents, a greater number of patients are achieving hitherto unthought-of responses, with many expecting to meet the requirement for VGPR or greater. Multiple factors can impact the quantification and assessment of response in patients achieving deep responses including the influence of IgG recycling, accuracy of quantitation against an increasing polyclonal background and the presence of monoclonal immuno

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Boettcher, Sebastian, Stephan Stilgenbauer, Raymonde Busch, Monika Brüggemann, Thorsten Raff, Kirsten Fischer, Günter Fingerle-Rowson, et al. "Standardized MRD Flow and ASO IGH RQ-PCR for MRD Quantification in CLL Patients after Rituximab-Containing Immunochemotherapy – a Comparative Analysis in 574 Samples from the Randomized GCLLSG CLL8 Trial." Blood 112, no. 11 (November 16, 2008): 3139. http://dx.doi.org/10.1182/blood.v112.11.3139.3139.

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Abstract Combinations of purine analogues with the therapeutic anti-CD20 antibody Rituximab induce a high number of complete clinical remissions in CLL patients. Therefore, the detection of minimal residual disease (MRD) appears particularly warranted after such regimens. However, Rituximab prevents the assessment of CD20, one mainstay of flow cytometric MRD detection (MRD flow) in CLL. As no comparative analysis of MRD flow to ASO primer IGH real-time quantitative PCR (RQ-PCR) after Rituximab has been performed so far, doubts remained regarding the diagnostic utility of MRD flow in this clini

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Humphrey, Kate E., Maria Mirica, Shobha Phansalkar, Al Ozonoff, and Marvin B. Harper. "Clinician Perceptions of Timing and Presentation of Drug-Drug Interaction Alerts." Applied Clinical Informatics 11, no. 03 (May 2020): 487–96. http://dx.doi.org/10.1055/s-0040-1714276.

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Abstract Objective Alert presentation of clinical decision support recommendations is a common method for providing information; however, many alerts are overridden suggesting presentation design improvements can be made. This study attempts to assess pediatric prescriber information needs for drug–drug interactions (DDIs) alerts and to evaluate the optimal presentation timing and presentation in the medication ordering process. Methods Six case scenarios presented interactions between medications used in pediatric specialties of general medicine, infectious disease, cardiology, and neurology.

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Dejoie, Thomas, Michel Attal, Philippe Moreau, and Herve Avet-Loiseau. "Serum Free Light Chain Responses Have Greater Concordance with Clinical Outcomes Than Those Assessed By Urine Electrophoresis in Light Chain Multiple Myeloma Patients." Blood 128, no. 22 (December 2, 2016): 376. http://dx.doi.org/10.1182/blood.v128.22.376.376.

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Abstract Introduction Guidelines for monitoring light chain multiple myeloma (LCMM) patients currently rely on measurements of the monoclonal protein in urine (Bence Jones proteinuria). However, the presence of light chains in the urine is highly influenced by the individual free light chain, production rate and renal function, which may make accurate monitoring challenging. Serum free light chain measurements are recommended as diagnostic aid for identifying patients with monoclonal gammopathies and as tools to monitor patients with AL amyloidosis and oligo-secretory MM. The correlation betwe

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Tengowski, Mark W. "Image Compression in Morphometry Studies Requiring 21 CFR Part 11 Compliance: Procedure Is Key with TIFFs and Various JPEG Compression Strengths." Toxicologic Pathology 32, no. 2 (February 2004): 258–63. http://dx.doi.org/10.1080/01926230490274399.

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This study aims to compare the integrity and reproducibility of measurements created from uncompressed and compressed digital images in order to implement compliance with 21 CFR Part 11 for image analysis studies executed using 21 CFR Part 58 compliant capture systems. Images of a 400-mesh electron microscope grid and H&E stained rat liver tissue were captured on an upright microscope with digital camera using commercially available analysis software. Digital images were stored as either uncompressed TIFFs or in one of five different levels of JPEG compression. The grid images were analyze

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Gattei, V., D. Benedetti, D. Marconi, M. Dal Bo, A. Zucchetto, G. Del Poeta, A. Steffan, R. Bomben, R. Campanini, and M. Degan. "Gene and surface-antigen expression profilings concordantly identify alpha4-integrin/CD49d as a marker for unmutated (UM) bad prognosis B-cell chronic lymphocytic leukemia (B-CLL)." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 10076. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.10076.

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10076 Background: The highly heterogeneous clinical courses of B-CLL can be foreseen by investigating IgVH gene mutations or expression of specific prognosticators. Gene and surface-antigen expression profilings (GEP and SEP) have been both employed for identifying molecules of prognostic relevance in B-CLL. Methods: i) GEP - Purified B-CLL cells from 19 UM and 38 mutated (M) cases were investigated for differential GEP by using a two-color Operon Human Genome Oligo Set 2.1 platform with normal B cells as common reference and by applying, after data pre-processing, the LIMMA (Linear Model for

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Eveillard, Marion, Even Rustad, Mikhail Roshal, Yanming Zhang, Amanda Ciardiello, Neha Korde, Malin Hultcrantz, et al. "Using MALDI-TOF mass spectrometry for tracking of minimal residual disease in peripheral blood from patients with multiple myeloma." Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): e19525-e19525. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e19525.

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e19525 Background: Minimal residual disease (MRD) negativity after completed therapy is associated with longer progression-free survival (PFS) in patients with multiple myeloma (MM). Current standard of care for MRD testing use flow cytometry and/or next generation sequencing (NGS)-based assays applied on bone marrow (BM) aspirate samples. To develop a strategy for MRD tracking in peripheral blood (PB), we were motivated to evaluate MALDI-TOF head-to-head with established bone marrow-based MRD assays. Methods: We used MALDI-TOF mass spectrometry to detect M-proteins in PB. Our cohort included

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