Relevant bibliographies by topics / Discovery of novel enzymes

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Discovery of novel enzymes'

Author: Grafiati
Published: 5 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Discovery of novel enzymes"

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P, Keerthi, Lathif AK, and Nesaghi Amuthavel. "Enzyme Technology for Drug Discovery." Journal of Chemical Engineering & Process Technology 14, no. 14 (2023): 8. https://doi.org/10.35248/2157-7048.23.14.471.

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Enzymes are biochemical catalysts that facilitate chemical reactions under Physiological conditions. Currently enzymes are being employed in industrial biotechnology for numerous purposes for the production of novel and sustainable products at a speedy rate. Enzyme technology is the change of an enzyme's structure or catalytic activity in order to produce new metabolites or participate in new reaction pathways. Simultaneously, significant technical advancements are encouraging the chemical and pharmaceutical sectors to embrace enzyme technology, a movement fueled by worries about health, energ
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Buryska, Tomas, Lukas Daniel, Antonin Kunka, Jan Brezovsky, Jiri Damborsky, and Zbynek Prokop. "Discovery of Novel Haloalkane Dehalogenase Inhibitors." Applied and Environmental Microbiology 82, no. 6 (2016): 1958–65. http://dx.doi.org/10.1128/aem.03916-15.

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ABSTRACTHaloalkane dehalogenases (HLDs) have recently been discovered in a number of bacteria, including symbionts and pathogens of both plants and humans. However, the biological roles of HLDs in these organisms are unclear. The development of efficient HLD inhibitors serving as molecular probes to explore their function would represent an important step toward a better understanding of these interesting enzymes. Here we report the identification of inhibitors for this enzyme family using two different approaches. The first builds on the structures of the enzymes' known substrates and led to
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Dellafiora, Luca, Christoph Gonaus, Barbara Streit, et al. "An In Silico Target Fishing Approach to Identify Novel Ochratoxin A Hydrolyzing Enzyme." Toxins 12, no. 4 (2020): 258. http://dx.doi.org/10.3390/toxins12040258.

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Ochratoxin A (OTA), a mycotoxin that is of utmost concern in food and feed safety, is produced by fungal species that mainly belong to the Aspergillus and Penicillium genera. The development of mitigation strategies to reduce OTA content along the supply chains is key to ensuring safer production of food and feed. Enzyme-based strategies are among the most promising methods due to their specificity, efficacy, and multi-situ applicability. In particular, some enzymes are already known for hydrolyzing OTA into ochratoxin alpha (OTα) and phenylalanine (Phe), eventually resulting in detoxification
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Yi, Dong, Thomas Bayer, Christoffel P. S. Badenhorst, et al. "Recent trends in biocatalysis." Chemical Society Reviews 50, no. 14 (2021): 8003–49. http://dx.doi.org/10.1039/d0cs01575j.

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Technological developments enable the discovery of novel enzymes, the advancement of enzyme cascade designs and pathway engineering, moving biocatalysis into an era of technology integration, intelligent manufacturing and enzymatic total synthesis.
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Jung, Da-Woon, Woong-Hee Kim, and Darren R. Williams. "Chemical genetics and its application to moonlighting in glycolytic enzymes." Biochemical Society Transactions 42, no. 6 (2014): 1756–61. http://dx.doi.org/10.1042/bst20140201.

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Glycolysis is an ancient biochemical pathway that breaks down glucose into pyruvate to produce ATP. The structural and catalytic properties of glycolytic enzymes are well-characterized. However, there is growing appreciation that these enzymes participate in numerous moonlighting functions that are unrelated to glycolysis. Recently, chemical genetics has been used to discover novel moonlighting functions in glycolytic enzymes. In the present mini-review, we introduce chemical genetics and discuss how it can be applied to the discovery of protein moonlighting. Specifically, we describe the appl
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Celik, Cagla, Didar Tasdemir, Ayse Demirbas, et al. "Formation of functional nanobiocatalysts with a novel and encouraging immobilization approach and their versatile bioanalytical applications." RSC Advances 8, no. 45 (2018): 25298–303. http://dx.doi.org/10.1039/c8ra03250e.

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The discovery of functional organic–inorganic hybrid nanoflowers (FNFs) consisting of proteins/enzymes as the organic components and Cu(ii) ion as the inorganic component has made an enormous impact on enzyme immobilization studies.
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Kumari, Saroj. "Recent Trends in Omics-Based Enzyme Discovery to Combat Global Plastic Waste Crisis." Biotechnology Kiosk 3, no. 5 (2021): 4–12. http://dx.doi.org/10.37756/bk.21.3.5.1.

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The worldwide rapidly increasing amount of plastic waste is considered a major concern in the environmental crisis today. Recycling post-consumer plastics is believed to be a viable approach to mitigate the global plastic waste challenge. Plastic recycling is considered attractive due to the reason that it could help achieve waste valorization while meeting the goals of environmental quality standards. To this end, the current research efforts are heavily focused towards developing innovative technologies for new enzyme discoveries for effective plastic waste management. Recent research has sh
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Yan, Junjun, Peng Chen, Yan Zeng, et al. "The Characterization and Modification of a Novel Bifunctional and Robust Alginate Lyase Derived from Marinimicrobium sp. H1." Marine Drugs 17, no. 10 (2019): 545. http://dx.doi.org/10.3390/md17100545.

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Alginase lyase is an important enzyme for the preparation of alginate oligosaccharides (AOS), that possess special biological activities and is widely used in various fields, such as medicine, food, and chemical industry. In this study, a novel bifunctional alginate lyase (AlgH) belonging to the PL7 family was screened and characterized. The AlgH exhibited the highest activity at 45 °C and pH 10.0, and was an alkaline enzyme that was stable at pH 6.0–10.0. The enzyme showed no significant dependence on metal ions, and exhibited unchanged activity at high concentration of NaCl. To determine the
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Reisky, Lukas, Vishnu S. T. Srinivasamurthy, Chris P. S. Badenhorst, Simon P. Godehard, and Uwe T. Bornscheuer. "A Novel High-Throughput Assay Enables the Direct Identification of Acyltransferases." Catalysts 9, no. 1 (2019): 64. http://dx.doi.org/10.3390/catal9010064.

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Acyltransferases are enzymes that are capable of catalyzing the transesterification of non-activated esters in an aqueous environment and therefore represent interesting catalysts for applications in various fields. However, only a few acyltransferases have been identified so far, which can be explained by the lack of a simple, broadly applicable high-throughput assay for the identification of these enzymes from large libraries. Here, we present the development of such an assay that is based on the enzymatic formation of oligocarbonates from dimethyl carbonate and 1,6-hexanediol. In contrast t
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Robin, Frédéric, Julien Delmas, Elisabete Machado, Bernadette Bouchon, Luísa Peixe, and Richard Bonnet. "Characterization of the Novel CMT Enzyme TEM-154." Antimicrobial Agents and Chemotherapy 55, no. 3 (2010): 1262–65. http://dx.doi.org/10.1128/aac.01359-10.

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ABSTRACTTEM-154, identified in Portugal in 2004, associated the substitutions observed in the extended-spectrum β-lactamase (ESBL) TEM-12 and in the inhibitor-resistant penicillinase (IRT) TEM-33. This enzyme exhibited hydrolytic activity against ceftazidime and a low level of resistance to clavulanic acid. Surprisingly, the substitution Met69Leu enhanced the catalytic efficiency of oxyimino β-lactams conferred by the substitution Arg164Ser. Its discovery confirms the dissemination of the complex mutant group of TEM enzymes in European countries.
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Dissertations / Theses on the topic "Discovery of novel enzymes"

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Rashid, Goran M. M. "Discovery of novel lignin oxidizing enzymes from Sphingobacterium sp.T2." Thesis, University of Warwick, 2015. http://wrap.warwick.ac.uk/77852/.

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Bacterial lignin-degrading strain Sphingobacterium sp. T2 is reported as most active strain among 12 isolates and proteomic analysis of extracellular fractions gave hits for two superoxide dismutase enzymes. Two novel lignin-oxidising enzymes from Sphingobacterium sp. T2 were identified. Experimental and bioinformatic evidence revealed that these enzymes are extracellular superoxide dismutases, namely SOD1 and SOD2. Both enzyme genes have been cloned and overexpressed in Escherichia coli. The metal specificity of both enzymes was investigated using ICP-OES, UV-vis spectra and superoxide dismut
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Abudayyeh, Omar O. "Discovery of novel CRISPR enzymes for transcriptome engineering and human health." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/120887.

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Thesis: Ph. D. in Medical Engineering and Medical Physics, Harvard-MIT Program in Health Sciences and Technology, September 2018.<br>Page 399 blank. Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 210-229).<br>RNA plays important and diverse roles in biology, yet molecular tools to measure and manipulate RNA are limited. Recently, the bacterial adaptive immune system, CRISPR, has revolutionized our ability to manipulate DNA, but no known RNA-targeting versions exist. To discover parallel bacterial RNA-targeting systems that could be used for transcriptome en
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Sandhaus, Shayna. "Drug Candidate Discovery: Targeting Bacterial Topoisomerase I Enzymes for Novel Antibiotic Leads." FIU Digital Commons, 2017. https://digitalcommons.fiu.edu/etd/3561.

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Multi-drug resistance in bacterial pathogens has become a global health crisis. Each year, millions of people worldwide are infected with bacterial strains that are resistant to currently available antibiotics. Diseases such as tuberculosis, pneumonia, and gonorrhea have become increasingly more difficult to treat. It is essential that novel drugs and cellular targets be identified in order to treat this resistance. Bacterial topoisomerase IA is a novel drug target that is essential for cellular growth. As it has never been targeted by existing antibiotics, it is an attractive target. Topoisom
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Janowitz, Tobias. "In vivo and in vitro systems for the characterisation and discovery of novel enzymes." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613806.

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Wilson, Kris. "Novel screening techniques for the discovery of human KMO inhibitors." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/18743.

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Kynurenine 3-monooxygenase (KMO) is an enzyme central to the kynurenine pathway of tryptophan degradation. KMO is emerging as an increasingly important target for drug development. The enzyme is implicated in the development and progression of several neurodegenerative disorders, in the regulation of the immune response and in sterile systemic inflammation. Production of recombinant human enzyme is challenging due to the presence of transmembrane domains, which localise KMO to the outer mitochondrial membrane and render KMO insoluble in many in vitro expression systems. Although several in vit
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Mahasenan, Kiran V. "Discovery of novel small molecule enzyme inhibitors and receptor modulators through structure-based computational design." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1332367560.

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Reisky, Lukas [Verfasser], Uwe T. [Akademischer Betreuer] Bornscheuer, Uwe T. [Gutachter] Bornscheuer, Magali [Gutachter] Remaud-Simeon, and Emma [Gutachter] Master. "Discovery and Characterization of Novel Carbohydrate-Active Enzymes from Marine Bacteria / Lukas Reisky ; Gutachter: Uwe T. Bornscheuer, Magali Remaud-Simeon, Emma Master ; Betreuer: Uwe T. Bornscheuer." Greifswald : Universität Greifswald, 2019. http://d-nb.info/1188409018/34.

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Reisky, Lukas Verfasser], Uwe Theo [Akademischer Betreuer] [Bornscheuer, Uwe T. [Gutachter] Bornscheuer, Magali [Gutachter] Remaud-Simeon, and Emma [Gutachter] Master. "Discovery and Characterization of Novel Carbohydrate-Active Enzymes from Marine Bacteria / Lukas Reisky ; Gutachter: Uwe T. Bornscheuer, Magali Remaud-Simeon, Emma Master ; Betreuer: Uwe T. Bornscheuer." Greifswald : Universität Greifswald, 2019. http://nbn-resolving.de/urn:nbn:de:gbv:9-opus-27050.

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Kharalkar, Shilpa S. "Identification of Novel Allosteric Regulators of Human Erythrocyte Pyruvate Kinase." VCU Scholars Compass, 2006. http://hdl.handle.net/10156/2083.

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Sukul, Premankur [Verfasser], Lars I. [Gutachter] Leichert, and Robert [Gutachter] Kourist. "Functional metaproteomics to discover novel lipolytic enzymes / Premankur Sukul ; Gutachter: Lars I. Leichert, Robert Kourist ; Fakultät für Biologie und Biotechnologie." Bochum : Ruhr-Universität Bochum, 2018. http://d-nb.info/1163451975/34.

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Books on the topic "Discovery of novel enzymes"

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Dutt Tripathi, Abhishek, Kianoush Khosravi Darani, and Suresh Kumar Srivastava, eds. Novel Food Grade Enzymes. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-1288-7.

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Mu, Wanmeng, Wenli Zhang, and Qiuming Chen, eds. Novel enzymes for functional carbohydrates production. Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-33-6021-1.

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Walsh, Dan. The discovery: A novel. Revell, 2012.

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Onley, Glen. Discovery tree: A novel. Sunstone Press, 2002.

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Walsh, Dan. The discovery: A novel. Revell, 2012.

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S, Rapaka Rao, Sorer Heinz, and National Institute on Drug Abuse., eds. Discovery of novel opioid medications. U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Institute on Drug Abuse, 1995.

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S, Rapaka Rao, Sorer Heinz, and National Institute on Drug Abuse., eds. Discovery of novel opioid medications. U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Institute on Drug Abuse, 1995.

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S, Rapaka Rao, Sorer Heinz, and National Institute on Drug Abuse., eds. Discovery of novel opioid medications. U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Institute on Drug Abuse, 1995.

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S, Lee Jae, Obach R. Scott, and Fisher Michael B, eds. Drug metabolizing enzymes: Cytochrome P450 and other enzymes in drug discovery and development. FontisMedia SA, 2003.

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International Symposium on Agmatine and Imidazoline Systems (4th 2003 San Diego, Calif.). Agmatine and imidazolines: Their novel receptors and enzymes. New York Academy of Sciences, 2003.

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Book chapters on the topic "Discovery of novel enzymes"

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Moe, Luke A., Matthew D. McMahon, and Michael G. Thomas. "Functional Metagenomics as a Technique for the Discovery of Novel Enzymes and Natural Products." In Enzyme Technologies. John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9780470627303.ch1.

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Gardiner, Donald, John Dalton, and Sheena McGowan. "Chapter 7. Plasmodium falciparum Neutral Aminopeptidases: Development of Novel Anti-Malarials by Understanding Enzyme Structure." In Drug Discovery. Royal Society of Chemistry, 2011. http://dx.doi.org/10.1039/9781849733151-00169.

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Ufarté, Lisa, Sophie Bozonnet, Elisabeth Laville, et al. "Functional Metagenomics: Construction and High-Throughput Screening of Fosmid Libraries for Discovery of Novel Carbohydrate-Active Enzymes." In Microbial Environmental Genomics (MEG). Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3369-3_15.

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Aehle, Wolfgang, and Juergen Eck. "Discovery of Enzymes." In Enzyme Catalysis in Organic Synthesis. Wiley-VCH Verlag GmbH & Co. KGaA, 2012. http://dx.doi.org/10.1002/9783527639861.ch3.

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Croucher, Peter I., Ingunn Holen, and Philip G. Hargreaves. "Inhibiting cytokine-processing enzymes." In Novel Cytokine Inhibitors. Birkhäuser Basel, 2000. http://dx.doi.org/10.1007/978-3-0348-8450-1_5.

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Demirjian, David C., Pratik C. Shah, and Francisco Morís-Varas. "Screening for Novel Enzymes." In Topics in Current Chemistry. Springer Berlin Heidelberg, 1999. http://dx.doi.org/10.1007/3-540-68116-7_1.

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Karagecili, Hasan. "Potential Medicinal Plants Used in the Treatment of Alzheimer’s Disease." In Neurological Diseases and Treatments in Terms of Biochemistry. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053359357.5.

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Alzheimer’s disease is a progressive and chronic neurodegenerative disease of the brain and is the disease with the most involvement in dementia, with 50 million patients in the world. The following medications have been used to treat AD symptoms: galantamine, donepezil, rivastigmine, physostigmine (eserine), tacrine, and huperzine A. Their main method of action is AChE suppression to minimize the cholinergic deficit. The use of FDA-approved these drugs in treatment is aimed at short-term relief of symptoms rather than regressing the course of the disease. While FDA-approved anti-AD drugs are
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Jamieson, David, Sally A. Coulthard, and Alan V. Boddy. "Metabolism (Non-CYP Enzymes)." In Cancer Drug Discovery and Development. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-9135-4_14.

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Lu, Ming, Xiao-Qing Ma, Md Abu Saleh, and Fu-Li Li. "Thermophilic Cellulolytic Enzymes: From Discovery to Design." In Fungal Cellulolytic Enzymes. Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-0749-2_9.

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Leclair, Pascal. "Discovery of Proteins and Enzymes." In Landmark Experiments in Protein Science. CRC Press, 2023. http://dx.doi.org/10.1201/9781003379058-3.

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Conference papers on the topic "Discovery of novel enzymes"

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Begum, Aqsa, Ameen, Sanjay Shrinivas Nagar, R. S. Upendra, and R. Karthik. "Discovery of Novel Antifungal Agents from Polygonatum odoratum Targeting 14-Alpha Demethylase Enzyme for the Treatment of Black Fungus (Mucormycosis)." In 2024 International Conference on Intelligent Systems and Advanced Applications (ICISAA). IEEE, 2024. https://doi.org/10.1109/icisaa62385.2024.10829343.

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Su, Yuetong, Baoguo Wei, Xinyu Wang, Xu Li, and Lixin Li. "Recent research advances in Novel Class Discovery." In 2024 12th International Conference on Information Systems and Computing Technology (ISCTech). IEEE, 2024. https://doi.org/10.1109/isctech63666.2024.10845265.

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Michalski, Tomasz, Dawid Rymarczyk, Daniel Barczyk, and Bartosz Zieliński. "ProtoNCD: Prototypical Parts for Interpretable Novel Class Discovery." In ESANN 2024. Ciaco - i6doc.com, 2024. http://dx.doi.org/10.14428/esann/2024.es2024-70.

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Zhu, Lijun. "Discovery of novel spin-orbit effects for magnetization manipulation." In Spintronics XVII, edited by Henri Jaffrès, Jean-Eric Wegrowe, Manijeh Razeghi, and Joseph S. Friedman. SPIE, 2024. http://dx.doi.org/10.1117/12.3025435.

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Liu, Yu, Yaqi Cai, Qi Jia, Binglin Qiu, Weimin Wang, and Nan Pu. "Novel Class Discovery for Ultra-Fine-Grained Visual Categorization." In 2024 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR). IEEE, 2024. http://dx.doi.org/10.1109/cvpr52733.2024.01674.

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Cai, Yan, and Shuyan Sun. "Pathology Data Mining and Biomarker Discovery with Novel Algorithms." In 2025 4th International Conference on Sentiment Analysis and Deep Learning (ICSADL). IEEE, 2025. https://doi.org/10.1109/icsadl65848.2025.10933361.

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GERLT, JOHN A. "DISCOVERING NOVEL ENZYMES, METABOLITES AND PATHWAYS." In 23rd International Solvay Conference on Chemistry. WORLD SCIENTIFIC, 2014. http://dx.doi.org/10.1142/9789814603836_0012.

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Wood, Keith V. "Engineering luciferase enzymes and substrates for novel assay capabilities." In Biomedical Optics 2004, edited by Dan V. Nicolau and Ramesh Raghavachari. SPIE, 2004. http://dx.doi.org/10.1117/12.528447.

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Armstrong, Scott A. "Abstract IA22: Targeting histone modifying enzymes in leukemia." In Abstracts: AACR Special Conference: Pediatric Cancer at the Crossroads: Translating Discovery into Improved Outcomes; November 3-6, 2013; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.pedcan-ia22.

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Galindo, Juan de Dios, Ian Josué González Cruz, Alejandra Álvarez López, Abraham Ulises Chávez Ramírez, and Vanessa Vallejo Becerra. "Colorimetric sarcosine biosensor based on Molybdenum trioxide and sarcosine oxidase nanozymes." In Ingeniería: una transición hacia el futuro. Asociación Colombiana de Facultades de Ingeniería - ACOFI, 2024. http://dx.doi.org/10.26507/paper.3788.

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Research for new alternative early disease detection is relevant in order to improve healthcare. A novel study field in this area are biosensors, where the detection of biomarkers could be useful for disease prevention. Sarcosine has been a topic of study because, out of range, it's associated with prostate cancer. Additionally, it has been discovered that some nanostructures can imitate enzyme-like behavior, which can be applied as transductors in biosensors, and are called nanozymes. In this work, molybdenum trioxide nanozymes were synthetized, which in presence of hydrogen peroxide have per
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Reports on the topic "Discovery of novel enzymes"

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Granot, David, and Sarah M. Assmann. Novel regulation of transpiration by sugar signals within guard cells. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7597924.bard.

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Water is the major limiting factor in agriculture and stomata, composed of two guard cells and the pore they circumscribe, are the chief gates controlling plants’ water loss. The prevailing century old paradigm was that sugars act as an osmoticum in guard cells, contributing to the opening of the stomata. In contrast, we discovered that sugars close stomata and the closure is mediated by the sugar-sensing enzyme hexokinase (HXK) that triggers the abscisic acid (ABA)-signaling pathway within the guard cells. This new discovery suggests a sugar-sensing mechanism within guard cells that controls
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Schaffer, Arthur A., D. Mason Pharr, Joseph Burger, James D. Burton, and Eliezer Zamski. Aspects of Sugar Metabolism in Melon Fruit as Determinants of Fruit Quality. United States Department of Agriculture, 1994. http://dx.doi.org/10.32747/1994.7568770.bard.

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The cucurbit family, including melon, translocates the galactosyl-sucrose oligosaccharides, raffinose and stachyose, in addition to sucrose, from the source leaves to the fruit sink. The metabolism of these photoassimilates in the fruit sink controls fruit growth and development, including the horticulturally important phenomenon of sucrose accumulation, which determines melon fruit sweetness. During this research project we have characterized the complete pathway of galactosyl sucrose metabolism in developing fruit, from before anthesis until maturity. We have also compared the metabolic path
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Chikwana, Vimbai. Discovery of Novel Amidotransferase Activity Involved In Archaeosine Biosynthesis and Structural and Kinetic Investigation of QueF, an Enzyme Involved in Queuosine Biosynthesis. Portland State University Library, 2000. http://dx.doi.org/10.15760/etd.140.

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Nelson, Nathan, and Randy Schekman. Functional Biogenesis of V-ATPase in the Vacuolar System of Plants and Fungi. United States Department of Agriculture, 1996. http://dx.doi.org/10.32747/1996.7574342.bard.

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The vacuolar H+-ATPase (V-ATPase) is one of the most fundamental enzymes in nature. It pumps protons into the vacuolar system of eukaryotic cells and provides the energy for numerous transport systems. Through our BARD grant we discovered a novel family of membrane chaperones that modulate the amount of membrane proteins. We also elucidated the mechanism by which assembly factors guide the membrane sector of V-ATPase from the endoplasmic reticulum to the Golgi apparatus. The major goal of the research was to understand the mechanism of action and biogenesis of V-ATPase in higher plants and fun
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Dudareva, Natalia, Alexander Vainstein, Eran Pichersky, and David Weiss. Integrating biochemical and genomic approaches to elucidate C6-C2 volatile production: improvement of floral scent and fruit aroma. United States Department of Agriculture, 2007. http://dx.doi.org/10.32747/2007.7696514.bard.

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The specific objectives of approved proposal include to: 1. Elucidate the C6-C2 biochemical pathways leading to the biosynthesis of phenylacetaldehyde, phenylethyl alcohol and phenylethyl acetate in floral tissues of ornamentally important plants, pefunia and roses. 2. Isolate and characterrze genes responsible for the production of these C6-C2 compounds and those involved in the regulation of the pathway using genomic and transcriptomic tools. 3. Determine whether altering the expression of key genes of this pathway can result in changing the aroma characteristics of flowers. Aldehydes are in
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Avihingsanon, Yingyos, Jongkonnee Wongpiyabovorn, and Nattiya Hirankarn. Biomarker discovery in systemic lupus erythematosus: genome-methylation approaches : Research report. Chulalongkorn University, 2010. https://doi.org/10.58837/chula.res.2010.15.

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Discovery of novel biomarkers in lupus nephritis Biomarkers are needed for making diagnosis and prognosis. In lupus nephritis, conventional tests like urinalysis or serum creatinine remain inadequate for patient care. In this proposal, we focused on non-invasive tools like blood and urine mRNAs or proteins. We chose candidate genes involving regulatory T-cell, B-lymphocyte signatures or vascular protective factors. Expression of regulatory cell signature (FOXP3) in peripheral blood mononuclear cells is associated with activity of lupus nephritis. We found FOXP3 mRNA levels in PBMCs from patien
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Torok, Tamas. Targeted Discovery of Lignocellulose-Deconstructing Enzymes from Extremohilic Fungi. Office of Scientific and Technical Information (OSTI), 2017. http://dx.doi.org/10.2172/1462736.

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Gerngross, Tillman U. A Novel Method for Producing Transgenic Enzymes and Peptides. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada422909.

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Christopher, David A., and Avihai Danon. Plant Adaptation to Light Stress: Genetic Regulatory Mechanisms. United States Department of Agriculture, 2004. http://dx.doi.org/10.32747/2004.7586534.bard.

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Original Objectives: 1. Purify and biochemically characterize RB60 orthologs in higher plant chloroplasts; 2. Clone the gene(s) encoding plant RB60 orthologs and determine their structure and expression; 3. Manipulate the expression of RB60; 4. Assay the effects of altered RB60 expression on thylakoid biogenesis and photosynthetic function in plants exposed to different light conditions. In addition, we also examined the gene structure and expression of RB60 orthologs in the non-vascular plant, Physcomitrella patens and cloned the poly(A)-binding protein orthologue (43 kDa RB47-like protein).
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Schaffer, Arthur, Jack Preiss, Marina Petreikov, and Ilan Levin. Increasing Starch Accumulation via Genetic Modification of the ADP-glucose Pyrophosphorylase. United States Department of Agriculture, 2009. http://dx.doi.org/10.32747/2009.7591740.bard.

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The overall objective of the research project was to utilize biochemical insights together with both classical and molecular genetic strategies to improve tomato starch accumulation. The proposal was based on the observation that the transient starch accumulation in the immature fruit serves as a reservoir for carbohydrate and soluble sugar content in the mature fruit, thereby impacting on fruit quality. The general objectives were to optimize AGPase function and activity in developing fruit in order to increase its transient starch levels. The specific research objectives were to: a) perform
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