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Dissertations / Theses on the topic 'Discovery of novel enzymes'

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Published: 5 June 2025
Last updated: 1 August 2025

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1

Rashid, Goran M. M. "Discovery of novel lignin oxidizing enzymes from Sphingobacterium sp.T2." Thesis, University of Warwick, 2015. http://wrap.warwick.ac.uk/77852/.

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Bacterial lignin-degrading strain Sphingobacterium sp. T2 is reported as most active strain among 12 isolates and proteomic analysis of extracellular fractions gave hits for two superoxide dismutase enzymes. Two novel lignin-oxidising enzymes from Sphingobacterium sp. T2 were identified. Experimental and bioinformatic evidence revealed that these enzymes are extracellular superoxide dismutases, namely SOD1 and SOD2. Both enzyme genes have been cloned and overexpressed in Escherichia coli. The metal specificity of both enzymes was investigated using ICP-OES, UV-vis spectra and superoxide dismut
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2

Abudayyeh, Omar O. "Discovery of novel CRISPR enzymes for transcriptome engineering and human health." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/120887.

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Thesis: Ph. D. in Medical Engineering and Medical Physics, Harvard-MIT Program in Health Sciences and Technology, September 2018.<br>Page 399 blank. Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 210-229).<br>RNA plays important and diverse roles in biology, yet molecular tools to measure and manipulate RNA are limited. Recently, the bacterial adaptive immune system, CRISPR, has revolutionized our ability to manipulate DNA, but no known RNA-targeting versions exist. To discover parallel bacterial RNA-targeting systems that could be used for transcriptome en
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3

Sandhaus, Shayna. "Drug Candidate Discovery: Targeting Bacterial Topoisomerase I Enzymes for Novel Antibiotic Leads." FIU Digital Commons, 2017. https://digitalcommons.fiu.edu/etd/3561.

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Multi-drug resistance in bacterial pathogens has become a global health crisis. Each year, millions of people worldwide are infected with bacterial strains that are resistant to currently available antibiotics. Diseases such as tuberculosis, pneumonia, and gonorrhea have become increasingly more difficult to treat. It is essential that novel drugs and cellular targets be identified in order to treat this resistance. Bacterial topoisomerase IA is a novel drug target that is essential for cellular growth. As it has never been targeted by existing antibiotics, it is an attractive target. Topoisom
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4

Janowitz, Tobias. "In vivo and in vitro systems for the characterisation and discovery of novel enzymes." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613806.

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5

Wilson, Kris. "Novel screening techniques for the discovery of human KMO inhibitors." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/18743.

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Kynurenine 3-monooxygenase (KMO) is an enzyme central to the kynurenine pathway of tryptophan degradation. KMO is emerging as an increasingly important target for drug development. The enzyme is implicated in the development and progression of several neurodegenerative disorders, in the regulation of the immune response and in sterile systemic inflammation. Production of recombinant human enzyme is challenging due to the presence of transmembrane domains, which localise KMO to the outer mitochondrial membrane and render KMO insoluble in many in vitro expression systems. Although several in vit
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6

Mahasenan, Kiran V. "Discovery of novel small molecule enzyme inhibitors and receptor modulators through structure-based computational design." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1332367560.

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7

Reisky, Lukas [Verfasser], Uwe T. [Akademischer Betreuer] Bornscheuer, Uwe T. [Gutachter] Bornscheuer, Magali [Gutachter] Remaud-Simeon, and Emma [Gutachter] Master. "Discovery and Characterization of Novel Carbohydrate-Active Enzymes from Marine Bacteria / Lukas Reisky ; Gutachter: Uwe T. Bornscheuer, Magali Remaud-Simeon, Emma Master ; Betreuer: Uwe T. Bornscheuer." Greifswald : Universität Greifswald, 2019. http://d-nb.info/1188409018/34.

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8

Reisky, Lukas Verfasser], Uwe Theo [Akademischer Betreuer] [Bornscheuer, Uwe T. [Gutachter] Bornscheuer, Magali [Gutachter] Remaud-Simeon, and Emma [Gutachter] Master. "Discovery and Characterization of Novel Carbohydrate-Active Enzymes from Marine Bacteria / Lukas Reisky ; Gutachter: Uwe T. Bornscheuer, Magali Remaud-Simeon, Emma Master ; Betreuer: Uwe T. Bornscheuer." Greifswald : Universität Greifswald, 2019. http://nbn-resolving.de/urn:nbn:de:gbv:9-opus-27050.

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9

Kharalkar, Shilpa S. "Identification of Novel Allosteric Regulators of Human Erythrocyte Pyruvate Kinase." VCU Scholars Compass, 2006. http://hdl.handle.net/10156/2083.

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10

Sukul, Premankur [Verfasser], Lars I. [Gutachter] Leichert, and Robert [Gutachter] Kourist. "Functional metaproteomics to discover novel lipolytic enzymes / Premankur Sukul ; Gutachter: Lars I. Leichert, Robert Kourist ; Fakultät für Biologie und Biotechnologie." Bochum : Ruhr-Universität Bochum, 2018. http://d-nb.info/1163451975/34.

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11

Guest, Patrick. "The identification and characterisation of novel inhibitors of the 17β-HSD10 enzyme for the treatment of Alzheimer's disease". Thesis, University of St Andrews, 2016. http://hdl.handle.net/10023/10398.

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In 2015, an estimated 46.8 million people were living with dementia, a number predicted to increase to 74.7 million by 2030 and 131.5 million by 2050. Whilst there are numerous causes for the development of dementia, Alzheimer's disease is by far the most common, accounting for approximately 50-70% of all cases. Current therapeutic agents against Alzheimer's disease are palliative in nature, managing symptoms without addressing the underlying cause and thus disease progression and patient death remain a certainty. Whilst the main underlying cause for the development of Alzheimer's disease was
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12

Carpenter, Sarah Elizabeth. "Enzyme linked spectroscopic assays for Glyoxylate the use of Peptidylglycine alpha-Amidating Monoxygenase for the discovery of Novel alpha-Amidated hormones /." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001415.

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13

Wilkinson, Brendan Luke. "Synthesis of Novel Carbohydrate Based Enzyme Inhibitor Libraries Utilising Click Chemistry." Thesis, Griffith University, 2007. http://hdl.handle.net/10072/366473.

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Within a short timeframe, the CuI-catalysed 1,3-dipolar cycloaddition (1,3-DCR) of an organic azide to a terminal acetylene to form a 1,4-disubstituted-1,2,3-triazole, has emerged as a powerful synthetic transformation in combinatorial chemistry, organic synthesis and bioconjugation research. This synthetic methodology, now known as click chemistry, has had an appreciable impact in the drug discovery and biotechnology sectors and has shown broad scope and compatibility with small molecule and polymeric substrates. The application of this powerful synthetic transformation, specifically in carbo
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14

Chikwana, Vimbai Masiyanise. "Discovery of Novel Amidotransferase Activity Involved In Archaeosine Biosynthesis and Structural and Kinetic Investigation of QueF, an Enzyme Involved in Queuosine Biosynthesis." PDXScholar, 2011. https://pdxscholar.library.pdx.edu/open_access_etds/140.

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The 7-deazaguanosine nucleosides queuosine (Q) and archaeosine (G⁺) are two of the most structurally complex modified nucleosides found in tRNA. Q is found exclusively in the wobble position of tRNAGUN coding for the amino acids asparagine, aspartate, histidine and tyrosine in eukarya and bacteria, while (G⁺) occurs in nearly all archaeal tRNA at position 15. In archaea preQ₀ is inserted into tRNA by the enzyme tRNA-guanine transglycosylase (TGT), which catalyzes the exchange of guanine with preQ₀ to produce preQ₀-tRNA. The first objective of this study was to identify and characterize the enz
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15

Vance, Nicholas Robert. "Targeting dynamic enzymes for drug discovery efforts." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6517.

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Proteins are dynamic molecules capable of performing complex biological functions necessary for life. The impact of protein dynamics in the development of medicines is often understated. Science is only now beginning to unravel the numerous consequences of protein flexibility on structure and function. This thesis will encompass two case studies in developing small molecule inhibitors targeting flexible enzymes, and provide a thorough evaluation of their inhibitory mechanisms of action. The first case study focuses on caspases, a family of cysteine proteases responsible for executing the final
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16

Aspeborg, Henrik. "Discovery of fiber-active enzymes in Populus wood." Doctoral thesis, KTH, Biotechnology, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3801.

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<p>Renewable fibers produced by forest trees provide excellentraw material of high economic value for industrialapplications. Despite this, the genes and corresponding enzymesinvolved in wood fiber biosynthesis in trees are poorlycharacterized. This thesis describes a functional genomicsapproach for the identification of carbohydrate-active enzymesinvolved in secondary cell wall (wood) formation in hybridaspen.</p><p>First, a 3' target amplification method was developed toenable microarray-based gene expression analysis on minuteamounts of RNA. The amplification method was evaluated usingboth
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17

Walton, Thomas. "The discovery of novel actions." Thesis, University of Sheffield, 2011. http://etheses.whiterose.ac.uk/2204/.

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The aim of this research was to develop a behavioural paradigm capable of quantifying action acquisition. It takes the form of a series of experiments in which human participants learn to produce new actions with a joystick. Research questions were focussed on the behavioural implications of Redgrave and Gurney's (2006) theory that dopamine neurons in the ventral midbrain play a pivotal role in the reinforcement and reselection of motor output that is essential to action learning. The first study looked at the effect of delayed audio and visual reinforcement on the ability to learn stable hand
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18

Whetton, Stephen. "Novel imprinted polymers as artificial enzymes." Thesis, Aston University, 2001. http://publications.aston.ac.uk/9644/.

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Derivatives of L-histidine were investigated as suitable models for the Asp-His couple found in the catalytic triad of serine proteases. A combination of molecular dynamics and IH NMR spectroscopy suggested that the most populous conformations of N-acetyl-L-histidine and the N-acetyl-L-histidine anion were predominated by those in which the carboxylate group was gauche to the imidazole ring overcoming steric and electrostatic repulsion, suggesting there is an interaction between the carboxylate group and the imidazole ring. Kinetic studies, using imidazole, N-acetyl-L-histidine and the N-acety
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19

Larsbrink, Johan. "Strategies for the Discovery of Carbohydrate-Active Enzymes from Environmental Bacteria." Doctoral thesis, KTH, Glykovetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-126956.

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The focus of this thesis is a comparative study of approaches in discovery of carbohydrate-active enzymes (CAZymes). CAZymes synthesise, bind to, and degrade all the multitude of carbohydrates found in nature. As such, when aiming for sustainable methods to degrade plant biomass for the generation of biofuels, for which there is a strong drive in society, CAZymes are a natural source of environmentally friendly molecular tools. In nature, microorganisms are the principal degraders of carbohydrates. Not only do they degrade plant matter in forests and aquatic habitats, but also break down the m
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20

Liu, Ziyuan. "Developing novel enzymes for the laundry industry." Thesis, University of Newcastle Upon Tyne, 2011. http://hdl.handle.net/10443/1162.

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Grass stains containing chlorophyll are the most difficult stains to remove from cotton fabrics in laundry processes. The grass cell walls are highly complex networks of polysaccharides interlocking with each other, which makes it recalcitrant to enzyme degradation. In nature, glycoside hydrolases that target plant cell walls often contain noncatalytic carbohydrate binding modules (CBMs), which promote enzymes access to insoluble substrates and thus potentiate catalysis. This project aims to use xylan-specific CBMs to target enzymes in washing powder onto grass stains to improve the removal of
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21

Johnston, Lee Ann. "The investigation of two novel PDE4A enzymes." Thesis, University of Glasgow, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400759.

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22

Cramp, Rebecca Ann. "Novel nitrile degrading enzymes in thermophilic bacteria." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300058.

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23

Line, Kirsty. "Studies on novel industrial γ-lactamase enzymes." Thesis, University of Exeter, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408739.

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24

Ploscariu, Nicoleta Teodora. "Novel staphylococcal inhibitors of neutrophil granule enzymes." Diss., Kansas State University, 2018. http://hdl.handle.net/2097/38759.

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Doctor of Philosophy<br>Department of Biochemistry and Molecular Biophysics<br>Brian V. Geisbrecht<br>Neutrophils are our most abundant white blood cells and the first leukocytes to infiltrate sites of infection or damaged/healing tissue. Activation of neutrophils results in the mobilization of several types of granules stored within their cytosol, such as the so-called azurophilic granules, which either fuse with the maturing endophagocytic compartment or are released into the extracellular environment. One of the most abundant component of azurophilic granules is a heme-containing enzyme cal
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25

Luciakova, Dominika. "Characterisation of novel cytochrome P450-fusion enzymes." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/characterisation-of-novel-cytochrome-p450fusion-enzymes(08d9f0eb-666c-4f0f-b3ad-1fbf52555a0e).html.

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This study focuses on the characterisation of three novel cytochrome P450-partner (P450-fusion) enzymes of unknown structure and function. Despite several well-established P450 functions, new structures of P450s are published frequently, with the P450-redox partner fusion systems being among the most discussed, due to their enhanced activity and biotechnological potential. Other, more intriguing, P450-fusions involve partners with functions distinct from electron transfer. Understanding why evolution drove the ‘partner’ proteins to evolve into a single unit is often unclear, but provides an im
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26

Tiwana, Gaganpreet Singh. "Discovery and investigation of novel radiosensitising genes." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:ee44297c-9b01-4c31-a4f8-6be3585c3557.

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Radiotherapy is second only to surgery in the curative management of patients with cancer, and yet the molecular mechanisms that determine the sensitivity of tumours to radiation remain largely unclear. A high-throughput radiosensitivity screening method based on clonogenicity was developed and a siRNA library against kinase targets was screened. The gold standard colony formation endpoint was chosen for determining reproductive cell death after radiation treatment, since effects on proliferation often do not reflect survival. Thiamine pyrophosphokinase-1 (TPK1), a key component of Vitamin B1/
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27

Mehr, Kevin. "Discovery and engineering of carbohydrate-modifying enzymes using targeted high-throughput approaches." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/60247.

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Carbohydrate-modifying enzymes can be used for the enzymatic synthesis or cleavage of complex glycans. In this study, various high-throughput assays were assessed as methods for the discovery of glycoside hydrolases (GHs) and glycosyltransferases (GTs) within environmental samples. Fluorescence-activated cell sorting (FACS) was evaluated as an approach for the functional enrichment of sialyltransferase (ST) genes in environmental samples. A model ST from Campylobacter jejuni, CstI, was successfully enriched from a mixture of genomic DNA (proof-of-principle), but active STs could not be isolate
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28

Weise, Nicholas. "Discovery and development of class I lyase-like enzymes for biotechnological applications." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/discovery-and-development-of-class-i-lyaselike-enzymes-for-biotechnological-applications(260e414d-0651-44f7-8592-af83743808e9).html.

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This thesis reports the investigations of class I lyase-like enzymes with particular focus on aiding discovery of family members, and variants thereof, for biotechnological applications, such as biocatalytic synthesis of value-added compounds. Chapter 2 details computational investigations of class I lyase-like enzymes based on sequence and structural data. Using an initial set of structurally- and biochemically-characterised class I lyase like enzymes, patterns and relationships were identified and used to annotate publically-available sequences. This allowed the discovery of potential enzyme
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29

Miles, Zachary David. "Discovery and Biochemical Studies of Enzymes Involved in the Queuosine Biosynthetic Pathway." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/337363.

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Queuosine (Q) is a hypermodified nucleoside present at the wobble position in the 5'-GUN-3' anticodon loop of asparagine, aspartic acid, histidine, and tyrosine encoding tRNAs. This hypermodified base contains a 7-deazapurine structure common to many antibiotics, antivirals, and antineoplastic secondary metabolites. It is synthesized de novo in prokaryotes from GTP, whereas in eukaryotes it is ingested from dietary sources as the free-base queuine and exchanged for guanine in mature tRNA. Queuosine has been associated with many physiological phenomena such as cancer pathology, neoplasia, and v
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30

Ekici, Özlem Doğan. "Design, synthesis, and evaluation of novel irreversible inhibitors for caspases." Available online, Georgia Institute of Technology, 2004:, 2003. http://etd.gatech.edu/theses/available/etd-04062004-164633/unrestricted/ekici%5Fozlem%5Fd%5F200312%5Fphd.pdf.

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31

Wertz, Ingrid E. "Identification and characterization of novel ubiquitin ligase enzymes /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2004. http://uclibs.org/PID/11984.

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32

Townsend, Philip David. "The identification of novel inorganic carbon sensitive enzymes." Thesis, Durham University, 2010. http://etheses.dur.ac.uk/415/.

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Adenylyl cyclase catalyses the formation of the second messenger adenosine-3’, 5’-monophosphate from adenosine triphosphate, and is involved in a number of diverse signalling pathways in eukaryotes and prokaryotes. Adenylyl cyclases are diverse in their structure and biochemistry, and have been grouped into six distinct Classes (I–VI). The Class III cyclase homology domain comprises the majority of prokaryotic and eukaryotic adenylyl cyclases, and has been further divided into 4 sub-Classes (a-d) based on active site polymorphisms. A number of Class IIIb adenylyl cyclases display elevated cata
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33

Guilly, Selena. "Synthesis of novel acceptor substrates for glycosyltransferase enzymes." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/16997.

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Our research has been based on the biosynthetic pathway to <i>N</i>-linked glycoproteins, species which are comprised of an oligosaccharide moiety attached to the side-chain nitrogen atom of an asparagines residue in a peptide. In order to effectively study the steps involved in the biosynthesis of lipid-linked oligosaccharides and their subsequent transfer to a nascent protein in cotranslational modification processes, it is essential to have a source of pure dolichols in quantities sufficient to allow the synthesis of both biosynthetic intermediates and synthetic analogues in the pathways re
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34

Hollander, Zsuzsanna. "Novel approaches to biomarker discovery for heart health." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/44200.

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35

Poon, Wing-shan Rosana, and 潘穎珊. "Discovery and characterization of two novel subgroups ofcoronaviruses." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43278450.

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36

Wu, Ying, and 武盈. "Discovery and characterization of a novel porcine paramyxovirus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hdl.handle.net/10722/196086.

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Most emerging infectious diseases in humans are zoonotic agents. Since the emergence of severe acute respiratory syndrome (SARS), swine-origin influenza and avian influenza epidemics, the study of novel and emerging viruses with zoonotic potential has been considered more and more important. Paramyxoviruses have been known for their potential to cross species barrier and infect new hosts. In the last decade, a number of novel and emerging paramyxoviruses have been reported in various animals. Our research group recently identified three novel bat paramyxoviruses, Tuhoko viruses 1, 2 and 3 (Thk
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37

Islam, R. S. "Novel engineering tools to aid drug discovery processes." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1444794/.

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A major bottleneck in drug discovery is the production of soluble human recombinant protein for functional, biochemical and structural analyses. The level of recombinant protein expression is controlled by a complex relationship between both biological and engineering variables. Due to the inter-play between these variables and standard experimental methods, the identification of the key variables which lead to improved protein expression can sometimes be missed. This thesis presents a framework which underpins the generation of large quantities of soluble recombinant protein in E. coli in a r
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38

Lee, Na-Ra. "DISCOVERY OF NOVEL PHARMACOTHERAPEUTICS FOR SUBSTANCE USE DISORDERS." UKnowledge, 2019. https://uknowledge.uky.edu/pharmacy_etds/104.

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Substance use disorders are serious health concerns in the United States. Furthermore, the National Survey on Drug Use and Health reports a continuous increase in substance use disorders in the United States during the last 10 years. However, there are not many effective pharmacotherapeutics available for substance use disorders. The current dissertation is focused on research aimed at discovering pharmacotherapeutics for substance use disorders. First part of dissertation focused on discovering methamphetamine (METH) use disorder therapeutics targeting specific mechanism of METH action on dop
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Vázquez-Figueroa, Eduardo. "Development of a novel dehydrogenase and a stable cofactor regeneration system." Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/31685.

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Thesis (Ph.D)--Chemical Engineering, Georgia Institute of Technology, 2009.<br>Committee Chair: Bommarius, Andreas S.; Committee Member: Doyle, Donald F.; Committee Member: Koros, William J.; Committee Member: Moore, Jeffre C.; Committee Member: Prausnitz, Mark R. Part of the SMARTech Electronic Thesis and Dissertation Collection.
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Jordaan, Justin. "Isolation and characterization of a novel thermostable and catalytically efficient laccase from Peniophora sp. strain UD4." Thesis, Rhodes University, 2005. http://eprints.ru.ac.za/211/.

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41

Holbrook, Lisa-Marie. "The identification of novel platelet surface thiol isomerase enzymes." Thesis, University of Reading, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.529976.

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42

Carlson, Jacob Charles. "Continuous Directed Evolution of Enzymes with Novel Substrate Specificity." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11053.

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Methodological advances in directed evolution have already made it possible to discover useful biomolecules within months to years. A further acceleration of this process might make it possible to address outstanding challenges, or needs for which the current timescale is a fundamental barrier. To realize these goals would require transformative methodological advances in directed evolution. In Chapter One, current methods in directed evolution are briefly reviewed. In Chapter Two, a general platform for continuous directed evolution is presented. The method is used to evolve T7 RNA polymerase
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43

Speda, Jutta. "Methods development for metaproteomics-guided bioprospecting of novel enzymes." Doctoral thesis, Linköpings universitet, Kemi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-133206.

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Industrial biotechnology has been announced by several organizations and governments as a key enabling technology for the enhanced economic growth in a low-carbon and knowledge-based bioeconomy. An important goal to promote an environment friendly and sustainable industrial biotechnology is the discovery of new enzymes. To date, almost all enzymes used in industry have been discovered by pure culturing of microorganisms, however, it is known that less than 1% of all microorganisms can be obtained in pure cultures. The remaining majority of microorganisms is only viable by close biological inte
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Ardiani, Andressa. "Engineering novel suicide enzymes for improved cancer gene therapy." Pullman, Wash. : Washington State University, 2009. http://www.dissertations.wsu.edu/Dissertations/Spring2009/A_Ardiani_050609.pdf.

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Kerr, Tovah Briana. "Discovery and characterization of a novel myostatin in zebrafish." Online access for everyone, 2005. http://www.dissertations.wsu.edu/Thesis/Summer2005/T%5FKERR%5F080505.pdf.

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46

Hatziioanou, Diane. "Discovery and analysis of novel bacteriocins from gut bacteria." Thesis, University of East Anglia, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539358.

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47

Newman, Stephen. "The discovery and development of a novel photosolubilisation system." Thesis, University of East Anglia, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280998.

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Hart, James Dudley. "Approaches to spiro-heterocycles : novel scaffolds for drug discovery." Thesis, University of Southampton, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399611.

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49

Marsden, Philip Matthew. "Computational discovery of novel antiperspirant and deodorant active ingredients." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614175.

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50

Brennan, Paul Martin. "Using novel models of glioma for cancer discovery science." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9613.

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The prognosis for patients diagnosed with glioma has changed little over the past two decades. Many therapies that appeared promising in preclinical studies have been unsuccessful in the clinic. In an attempt to address this problem I developed a method for the efficient derivation of glioma primary cultures from fresh human brain tumours. These cultures are enriched for putative cancer stem-like cells that are thought to be responsible for glioma initiation, therapy resistance and recurrence. This mechanism of tumour development is a departure from the traditional multistep model of cancer. I
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