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Dissertations / Theses on the topic 'Discovery platform'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Zhang, Ziyang. "A Platform for the Discovery of New Macrolide Antibiotics." Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:33493421.

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The macrolide class of antibiotics has been widely used to treat bacterial infections for over 65 years. To date, all practical routes to clinically used macrolide antibiotics have relied on the chemical modification of the fermentation product erythromycin, a process referred to as semisynthesis. As bacterial resistance to semisynthetic macrolides emerges, a new approach to the discovery of structurally novel antibiotic candidates is urgently required. This dissertation presents a general and practical strategy for the synthesis of macrolide antibiotics based on the convergent assembly of si

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Albin, Aaron. "Building an online UMLS knowledge discovery platform using graph indexing." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1398946883.

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Ekström, Alexander Gösta. "Developing dynamic combinatorial chemistry as a platform for drug discovery." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31073.

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Dynamic combinatorial chemistry (DCC) is a powerful tool to identify new ligands for biological targets. In the technique, library synthesis and hit identification are neatly combined into a single step. A labile functionality between fragments allows the biological target to self-select binders from a dynamic combinatorial library (DCL) of interconverting building blocks. The scope of suitable reversible reactions that proceed under thermodynamic control in physiological conditions has been gradually expanded over the last decades, however DCC has thus far failed to gain traction as a techniq

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4

Larsson, carl. "Service Design and Web Development for Implementing a Social Discovery Platform." Thesis, Umeå universitet, Institutionen för tillämpad fysik och elektronik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-67732.

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This thesis revolves around the implementation and design of a social discovery web service called Go&Grow whose beta version was launched in september 2012. The aim of this study was to conduct a theoretical analysis of service design, putting it in comparison to other design disciplines, and finding key points in designing this web service. Another purpose was to start the implementation of the service using the web framework Django and further to evaluate different web techniques used to build such a system. Methods applied in this study were taken from literature describing the servic

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Wu, Chen. "Service distribution and service discovery through a public web services platform." Thesis, Curtin University, 2008. http://hdl.handle.net/20.500.11937/387.

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Service-Oriented Architecture (SOA) represents an emerging architectural approach that is able to tackle challenges in the contemporary service-based economy, in which the global market revenues are shifting from the manufacture of traditional off-the-shelf products to the provision of diversified services that suffice for customers’ needs. In such a service-based economy, one can envisage an entirely “service-oriented” world, where a massive number of distributed services with different natures and capabilities are provided by various professionals around the world. Problems arise when busine

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Wu, Chen. "Service distribution and service discovery through a public web services platform." Curtin University of Technology, Digital Ecosystems and Business Intelligence Institute, 2008. http://espace.library.curtin.edu.au:80/R/?func=dbin-jump-full&object_id=17919.

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Service-Oriented Architecture (SOA) represents an emerging architectural approach that is able to tackle challenges in the contemporary service-based economy, in which the global market revenues are shifting from the manufacture of traditional off-the-shelf products to the provision of diversified services that suffice for customers’ needs. In such a service-based economy, one can envisage an entirely “service-oriented” world, where a massive number of distributed services with different natures and capabilities are provided by various professionals around the world. Problems arise when busine

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Feoli, Alessandra. "Biomolecular and biophysical approaches to interrogate epigenetic targets: a platform for drug discovery." Doctoral thesis, Universita degli studi di Salerno, 2016. http://hdl.handle.net/10556/2168.

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2014 - 2015<br>The term epigenetics refers to heritable changes in gene expression that do not involve changes in the DNA sequence. A large number of enzymes, which act mainly on histone tails and DNA, carries out epigenetic modifications, influencing several biological mechanisms. The interplay between epigenetic enzymes and chromatin is highly complex, and despite great progress has been made in understanding the role of these proteins in biological contexts, much remains still unknown. On the other hand, it is widely reported that specific epigenetic modifications are associated with disea

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Nimer, Nisreen. "Mass Spectrometry as Discovery Platform for Candidate Metabolite of Non-Alcoholic Steatohepatitis (NASH)." Cleveland State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=csu158913072730028.

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9

Grünzner, S., F. V. Reddavide, C. Steinfelder, et al. "Lab-on-a-chip platform for high throughput drug discovery with DNAencoded chemical libraries." SPIE, 2017. https://tud.qucosa.de/id/qucosa%3A34877.

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The fast development of DNA-encoded chemical libraries (DECL) in the past 10 years has received great attention from pharmaceutical industries. It applies the selection approach for small molecular drug discovery. Because of the limited choices of DNA-compatible chemical reactions, most DNA-encoded chemical libraries have a narrow structural diversity and low synthetic yield. There is also a poor correlation between the ranking of compounds resulted from analyzing the sequencing data and the affinity measured through biochemical assays. By combining DECL with dynamical chemical library, the re

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Raje, Satyajeet. "ResearchIQ: An End-To-End Semantic Knowledge Platform For Resource Discovery in Biomedical Research." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1354657305.

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ZOPPI, VITTORIA. "Studies on Proteolysis Targeting Chimeras: platform technology for targeted protein degradation in drug discovery." Doctoral thesis, Università degli studi di Genova, 2019. http://hdl.handle.net/11567/940923.

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Proteolysis Targeting Chimeras (PROTACs) represent an innovative approach to chemical intervention into biology, with attractive therapeutic potential. In contrast to protein inhibition, PROTACs trigger targeted protein degradation inside cells via hijacking the ubiquitinproteasome machinery. PROTACs are bifunctional compounds composed by two small molecules connected by a linker; one molecule binds to a protein of interest and the other one binds to an E3 ubiquitin ligase. The ligases most commonly recruited are the von Hippel- Lindau (VHL) protein complex CRL2VHL and the cereblon (CRBN

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12

Martínez, Rosell Gerard 1990. "Applications of molecular dynamics in drug discovery and technology transfer via a web-based platform." Doctoral thesis, Universitat Pompeu Fabra, 2017. http://hdl.handle.net/10803/665077.

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In this thesis we apply molecular dynamics (MD) simulations and other in silico techniques in drug discovery. Specifically, (a) we developed an algorithm to detect cryptic pockets based on MD simulations of the protein solvated in a mixture of water and benzene, (b) we performed the first 150-fragment screening against the chemokine CXCL12 using a MD-driven protocol and (c) we studied the conformational plasticity of the μ-opioid receptor (MOR) bound to two different drugs to study the molecular basis of selective modulation. Additionally, we created a web platform entitled PlayMolecule, wher

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13

Taylor, Seth. "Wheel of fortune--the evoluation of a drug discovery platform through strategic alliances and acquisitions." Thesis, Massachusetts Institute of Technology, 1997. http://hdl.handle.net/1721.1/10542.

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Åberg, Cécile. "An Evaluation Platform for Semantic Web Technology." Doctoral thesis, Linköpings universitet, IISLAB - Laboratoriet för intelligenta informationssystem, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-7904.

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The vision of the Semantic Web aims at enhancing today's Web in order to provide a more efficient and reliable environment for both providers and consumers of Web resources (i.e. information and services). To deploy the Semantic Web, various technologies have been developed, such as machine understandable description languages, language parsers, goal matchers, and resource composition algorithms. Since the Semantic Web is just emerging, each technology tends to make assumptions about different aspects of the Semantic Web's architecture and use, such as the kind of applications that will be dep

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Chen, Qilei. "Discovery of COX-2 selective inhibitors from saussurea laniceps using an enzyme-anchored nanomagnetic ligand fishing platform." HKBU Institutional Repository, 2020. https://repository.hkbu.edu.hk/etd_oa/708.

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Serious cardiovascular side effects are reported from synthetic cyclooxygenase-2 (COX-2) selective nonsteroidal anti-inflammatory drugs, the most common medication for rheumatoid arthritis (RA) and osteoarthritis (OA). Natural products from herbal medicine are inspirational source of safe and effective remedy due to its distinguished chemical diversity. Nanomagnetic ligand fishing using enzyme-anchored-magnetic nanoparticles (MNPs) is an advanced selective bioseparation strategy based on macromolecular target-ligand binding, which can screen enzyme inhibitors from complex mixtures. "Snow lotus

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Hassani-Pak, Keywan [Verfasser], Ralf [Akademischer Betreuer] Hofestädt, and Christopher [Akademischer Betreuer] Rawlings. "KnetMiner - An integrated data platform for gene mining and biological knowledge discovery / Keywan Hassani-Pak ; Ralf Hofestädt, Christopher Rawlings." Bielefeld : Universitätsbibliothek Bielefeld, 2017. http://d-nb.info/1150181532/34.

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Lui, Bonny Gaby [Verfasser]. "Targeting the Tumor Vasculature with an Engineered Cystine-Knot Miniprotein Applying an Optimized Phage Display Discovery Platform / Bonny Gaby Lui." Mainz : Universitätsbibliothek Mainz, 2019. http://d-nb.info/1187376523/34.

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Lee, Bill. "Preclinical antimicrobial drug discovery : development and evaluation of a platform for high-throughput screening in vitro and an immunocompromised animal model." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=100745.

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The incidence of infections caused by antibiotic-resistant bacteria and fungi is rising rapidly. Once considered as little more than a nuisance, antibiotic resistance has become a serious threat. The mortality rate for some infections is approaching that of the pre-antibiotic era. New antimicrobials are needed urgently. Prior to the introduction of any new antimicrobial, comprehensive toxicity and efficacy profiles are assessed in preclinical studies. This thesis focuses on two key stages of preclinical antimicrobial drug development, specifically compound screening in vitro and animal efficac

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PISANI, GIUSEPPE. "Training-to-Beat bioreactor for investigating Engineered Cardiac Tissues: design, development & validation." Doctoral thesis, Politecnico di Torino, 2016. http://hdl.handle.net/11583/2645083.

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In last the decades, advances relevant to the generation of 3D Engineered Cardiac Tissues (ECTs) have been made. In reason of this, ECTs are now considered a great promise for in vitro studies of cardiac development, disease and, eventually, for strategies for the repair of the structure and function of the injured myocardium. Among the several physical stimuli which have been exploited to improve the functionality and maturation of ECTs, a preeminent role has been ascribed to mechanical stimulation. Appropriate mechanical stimulation can be recreated and maintained within bioreactors, which

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El, Bardisy Shaheer [Verfasser]. "Development of a High-Throughput Single-Cell Sequencing Platform for the Discovery of Shared-Antigen and Neoepitope-Specific T-Cell Receptors / Shaheer El Bardisy." Mainz : Universitätsbibliothek Mainz, 2020. http://d-nb.info/1211519929/34.

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Sequeira, Ana Filipa Pereira. "Development of a novel platform for high-throughput gene design and artificial gene synthesis to produce large libraries of recombinant venom peptides for drug discovery." Doctoral thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2016. http://hdl.handle.net/10400.5/12265.

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Tese de Doutoramento em Ciências Veterinárias na Especialidade de Ciências Biológicas e Biomédicas<br>Animal venoms are complex mixtures of biologically active molecules that, while presenting low immunogenicity, target with high selectivity and efficacy a variety of membrane receptors. It is believed that animal venoms comprise a natural library of more than 40 million different natural compounds that have been continuously fine-tuned during the evolutionary process to disturb cellular function. Within animal venoms, reticulated peptides are the most attractive class of molecules for drug dis

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Carpenter, Sarah Elizabeth. "Enzyme linked spectroscopic assays for Glyoxylate the use of Peptidylglycine alpha-Amidating Monoxygenase for the discovery of Novel alpha-Amidated hormones /." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001415.

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Cavalcante, Renata de Souza Alves Paula. "DESCOBERTA DE CONHECIMENTO NA PLATAFORMA LATTES: UM ESTUDO DE CASO NO INSTITUTO FEDERAL DE GOIÁS." Pontifícia Universidade Católica de Goiás, 2014. http://localhost:8080/tede/handle/tede/2450.

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Made available in DSpace on 2016-08-10T10:40:21Z (GMT). No. of bitstreams: 1 RENATA DE SOUZA ALVES PAULA CAVALCANTE.pdf: 3920138 bytes, checksum: 5a8a21fa7b849ef942fb6113dc3f6635 (MD5) Previous issue date: 2014-02-24<br>Ao longo do tempo, percebeu-se que a velocidade do acúmulo de informações era maior do que a velocidade de processamento e análise das mesmas. Não adianta uma organização ter muita informação, se não souber dela extrair conhecimento útil. É preciso que sejam feitas análises apuradas sobre os dados e descobrir quais são os padrões de comportamentos existentes nos mesmos. Assim

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Mader, Pavel. "Dolovací moduly systému pro dolování z dat v prostředí Oracle." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2009. http://www.nusl.cz/ntk/nusl-236690.

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This master's thesis deals with questions of the data mining and an extension of a data mining system in the Oracle environment developed at FIT. So far, this system cannot apply to real-life conditions as there are no data mining modules available. This system's core application design includes an interface allowing the addition of mining modules. Until now, this interface has been tested on a sample mining module only; this module has not been executing any activity just demonstrating the use of this interface. The main focus of this thesis is the study of this interface and the implementati

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Zapletal, Petr. "Dolovací modul systému pro získávání znalostí z dat FIT-Miner." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2011. http://www.nusl.cz/ntk/nusl-236921.

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This master's thesis deals with with FIT-Miner, the system for knowledge discovery in databases. The first part of this paper describes the data-mining process, mixture model's issues and FIT-Miner system. Second part deals with design, implementation and testing of created module, which is used for cluster analysis with Expectation-Maximalization algorithm. The end of the paper is focused to design of modules using Java Store Procedures Technology.

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Andrew, Brandon E. "DETERMINATION OF STRATEGIC PRIORITIES FOR A MICROBIOME COMPANY THROUGH ANALYSIS OF TECHNICAL CAPABILITIES AND CURRENT MARKET LANDSCAPES." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1586527376213742.

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Šebek, Michal. "Rozšíření funkcionality systému pro dolování z dat na platformě NetBeans." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2009. http://www.nusl.cz/ntk/nusl-236729.

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Databases increase by new data continually. A process called Knowledge Discovery in Databases has been defined for analyzing these data and new complex systems has been developed for its support. Developing of one of this systems is described in this thesis. Main goal is to analyse the actual state of implementation of this system which is based on the Java NetBeans Platform and the Oracle database system and to extend it by data preprocessing algorithms and the source data analysis. Implementation of data preprocessing components and changes in kernel of this system are described in detail in

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Havlíček, David. "Vytvoření nových predikčních modulů v systému pro dolování z dat na platformě NetBeans." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2009. http://www.nusl.cz/ntk/nusl-236768.

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The issue of this master's thesis is a creation of new prediction unit for existing system of knowledge discovery in database. The first part of project deal with general problems of knowledge discovery in database and predictive analysis. The second part of the project deal with system developed on FIT, for which is module implemented, used technologies, concept and implementation of mining module for this system. The solution is implemented in Java language and is a built on the NetBeans platform.

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Wujcik, Evan K. "Discovery of Nanostructured Material Properties for Advanced Sensing Platforms." University of Akron / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=akron1374414126.

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Maraczek, Patrik. "Návrh a realizace systému zpracování dat z environmentálních čidel v prostředí IoT." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2020. http://www.nusl.cz/ntk/nusl-417775.

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The master’s thesis deal with design and realization of measuring station, which process data from environmental sensors in IoT environment. Thesis includes research of sensors, cloud services for IoT, microcontrollers and environmental data available online. Thesis contains detailed procedure for realization of designed system, including code description for microcontrollers STM32W55 and STM32 B-L475E-IOT01A2 Discovery kit, configuration of IBM Watson IoT Platform cloud service and procedure for correct programming of Node-RED application responsible for logic of whole system. Source code, wh

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Pevzner, Yuri. "Development and application of web-based open source drug discovery platforms." Scholar Commons, 2015. https://scholarcommons.usf.edu/etd/5550.

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Computational modeling approaches have lately been earning their place as viable tools in drug discovery. Research efforts more often include computational component and the usage of the scientific software is commonplace at more stages of the drug discovery pipeline. However, as software takes on more responsibility and the computational methods grow more involved, the gap grows between research entities that have the means to maintain the necessary computational infrastructure and those that lack the technical expertise or financial means to obtain and include computational component in thei

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Zhu, Dianzhuo. "Understanding Motivations and Impacts of Ridesharing : Three Essays on Two French Ridesharing Platforms The Impact of SNCF Strike on Ridesharing: A Novel Approach of Consumer Surplus Estimation Using BlaBlaCar.com Data The limit of money in daily ridesharing: Evidence from a field experiment,Technical report More Generous for Small Favour? Exploring the Role of Monetary and Prosocial Incentives of Daily Ride Sharing Using a Field Experiment in Rural Île-de-France." Thesis, Université Paris sciences et lettres, 2020. https://basepub.dauphine.fr/discover?query=%222020UPSLD003%22.

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La société moderne est confrontée à plusieurs défis causés par les voitures. Dans les villes urbaines, trop de voitures sur la route créent des embouteillages, de la pollution de l'air et du bruit. Dans les villages ruraux, les habitants deviennent de plus en plus dépendants de la voiture, ce qui limite le droit à la mobilité de la population vulnérable. Le covoiturage pourrait être une solution aux deux défis. La thèse tente de comprendre le comportement des participants au covoiturage. Les deux premiers articles sont deux expériences de terrain avec Ecov sur les motivations monétaires et pro

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Krásný, Michal. "Systém pro dolování z dat v prostředí Oracle." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2008. http://www.nusl.cz/ntk/nusl-236015.

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This MSc Project deals with the system of Knowledge Discovery in Databases. It is a client application which uses the Oracle Data Mining Server's 10.g Release 2 (10.2) services. The application is implemented in Java, the graphical user interface is built on the NetBeans Rich Client Platform. The theoretical part introduces the Knowledge Discovery in Databases, while the practical part describes functionality of the original system, it's deficiencies, documents sollutions of theese deficiencies and there are proposed improvements for further development. The goal of this project is to modify t

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Henkl, Tomáš. "Dolovací moduly systému pro dolování z dat na platformě NetBeans." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2009. http://www.nusl.cz/ntk/nusl-236656.

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The master's thesis deals with the knowledge discover in databases and with the extending of the data mining systems in the Oracle environment developed at the VUT FIT. The system kernel conception incorporates an interface that enables the adding of data mining modules. The objective of the thesis is to learn this interface and implement and embed the data mining module for decision-tree classification into the application. In addition, the thesis compares the application with similar commercial product SAS Enterprise Miner

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Griffiths, Natalie Helen. "Mechanisms of GABAA and glycine receptor analgesia in the spinal dorsal horn : in vitro models as translational platforms for drug discovery." Thesis, University of Leeds, 2015. http://etheses.whiterose.ac.uk/12560/.

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Available analgesics do not always provide adequate pain relief and are often associated with a significant side-effect profile. Following reports of a loss of inhibitory signalling in the spinal dorsal horn (DH) network in persistent pain conditions, γ-amino butyric acid type A (GABAA) and glycine receptors have been identified as promising targets. The present study assesses two in vitro models for their suitability for screening novel analgesics targeting GABAA and glycine receptors. Firstly, the embryonic cultured spinal DH cell model and secondly an acute rat spinal cord slice model. Immu

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BEZUKLADOVA, SVETLANA. "Development of an in vitro functional platform to discover new drugs for progressive multiple sclerosis and translation to preclinical animal models." Doctoral thesis, Università Vita-Salute San Raffaele, 2022. http://hdl.handle.net/20.500.11768/133063.

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Multiple sclerosis (MS), an inflammatory autoimmune disease characterised by myelin and axonal damage, is the major cause of progressive neurological disability in young adults. Most MS patients have a continuous accumulation of disability throughout their lifespan leading to progressive MS (PMS), still an incurable disease. The urgent challenge is the development of novel effective therapies for progressive forms of MS, which could slow or prevent ongoing neurodegeneration by targeting neuroprotection and remyelination. One of the rational approaches to achieve this goal is drug repurposing.

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Kmoščák, Ondřej. "Vytvoření nových klasifikačních modulů v systému pro dolování z dat na platformě NetBeans." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2009. http://www.nusl.cz/ntk/nusl-236632.

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This diploma thesis deals with the data mining and the creation of data mining unit for data mining system, which is beeing developed at FIT. This is a client application consisting of a kernel and its graphical user interface and independent mining modules. The application uses support of Oracle Data Mining. The data mining system is implemented in Java language and its graphical user interface is built on NetBeans platform. The content of this work will be the introduction into the issue of knowledge discovery and then the presentation of the chosen Bayesian classification method, for which

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Výtvar, Jaromír. "Dolovací modul systému pro dolování z dat na platformě NetBeans." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2010. http://www.nusl.cz/ntk/nusl-235551.

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The aim of this work is to get basic overview about the process of obtaining knowledge from databases - datamining and to analyze the datamining system developed at FIT BUT on the NetBeans platform in order to create a new mining module. We decided to implement a module for mining outliers and to extend existing regression module with multiple linear regression using generalized linear models. New methods using existing methods of Oracle Data Mining.

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PIRRONE, Dario. "DESIGN METHODOLOGIES TO ENABLE COLLECTIVE INTELLIGENCE IN PLATFORMS FOR HUMAN-HUMAN INTERACTION." Doctoral thesis, Università degli Studi di Palermo, 2014. http://hdl.handle.net/10447/91343.

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Chen, Zhifen [Verfasser], Karl-Ludwig [Akademischer Betreuer] Laugwitz, Alessandra [Gutachter] Moretti, Adnan [Gutachter] Kastrati, and Thomas [Gutachter] Gudermann. "Human iPSC-derived cardiomyocytes as platforms for cardiac disease modeling, therapeutic discovery and safety pharmacology / Zhifen Chen ; Gutachter: Alessandra Moretti, Adnan Kastrati, Thomas Gudermann ; Betreuer: Karl-Ludwig Laugwitz." München : Universitätsbibliothek der TU München, 2016. http://d-nb.info/1120584515/34.

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Yang, Yu-Ling, and 楊雨翎. "Platform development for anticancer metastasis drug discovery." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/3mpgu2.

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Zhang, Qiao-Yun, and 張巧蕓. "An IoT Service Discovery Platform with Heterogeneous Protocols." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/75t9x5.

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碩士<br>國立東華大學<br>資訊工程學系<br>105<br>With the advance of Internet of Things (IoT), it provides many intelligent features, and supports different transmission protocols (CoAP, MQTT, HTTP) and data exchange formats. However, heterogeneity in transmission protocols makes devices hard to communicate with each other and causes the bottleneck in the integration of software. Using IoT, we can monitor and control every “things” in lives at anytime and anywhere. The technique of service discovery starts being applied to the architecture of IoT. External services and functions can be easily acquired without

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Chun-YuTseng and 曾君宇. "A Distributed Region-Server-based Telematics Service Discovery Platform." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/12829471195598870761.

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碩士<br>國立成功大學<br>資訊工程學系碩博士班<br>98<br>In this paper, a distributed Telematics Peer-to-Peer (D-TP2P) networking system is proposed to provide an efficient and feasible service discovery mechanism for mobile users. When mobile users travel on the road, they may request for some services from service providers to meet their demands. mobile users in vehicles are assumed to go through a lot of regions, in which each region is associated with a region server. Related information of all service providers in a region is stored in its region server, and each region server is in charge of the service disc

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Tseng, Wan-Zou, and 曾婉柔. "Study On The Platform Development for Neurodegenerative Drug Discovery." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/58931756717637482550.

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碩士<br>國立陽明大學<br>生物藥學研究所<br>101<br>The accumulation of abnormal proteins especially in the brain associate with aging is related to neurodegenerative diseases. However, there is still no effective drugs for neurodegenerative disorders treatment, therefore it is still an unmet medical need. In our experiments, we used the incubated 11 amino acids, Aβ25-35 as Alzheimer’s disease model. In cell model, the mitochondria function damaged by 1μM Aβ25-35 was improved after 48h and 72h by 0.4 to 10 μg/ml EH-201 treatment not only in RBA-1 but also in primary astrocytes. After intracerebroventricular inj

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Duarte, Fernando José Fradique. "Platform for the discovery of newsworthy events in Twitter." Master's thesis, 2017. http://hdl.handle.net/10773/24806.

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The new communication paradigm established by Social Media, along with its growing popularity in recent years, have contributed to attract an increasing interest by several research fields. One such research field is the field of event detection in Social Media, whose relevance stems from its potential applicability in many diverse applications. One such application is the detection of newsworthy events in Social Media. The purpose of this work is therefore to implement a system to detect newsworthy events in Twitter. A similar system proposed in the literature is used as the base of this impl

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Hsu, Chin-Min, and 許勤敏. "Study on the platform development for skin care related drug discovery." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/sa8e3j.

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碩士<br>國立陽明大學<br>生物藥學研究所<br>102<br>Skin is the largest organ in the human body, which undergoes chronological aging. The primary environmental factor that causes human aging is UV irradiation. Excessively exposure to ultraviolet causes inflammation, photoaging and ultimately, photocarcinogenesis in skin. In this study, we focus on the mechanisms which leads to skin aging and develop the platform for skin care related drug discovery. We have identified active fraction from Chinese medicinal herb. Previous study showed active fraction is a potent EPO (erythropoietin) inducer in non-haematopoi

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Chen, Ying-Lan, and 陳盈嵐. "Development of the Plant Signaling Peptides Discovery Platform Using Mass Spectrometry." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/15092833836527076232.

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碩士<br>國立臺灣海洋大學<br>生物科技研究所<br>97<br>Increasing number of the studies revealed that signaling peptides were involved in plant growth and development. Compared with other organism, plant was predicted to have more signaling peptides and corresponding perceptive receptors. However, the small size of peptide molecules and their cDNA lead to the analysis of signaling peptides more difficult. To date, a limited number of peptide hormones in plant were observed. This is due to the lack of analytical platforms for the study of signaling peptides. In this study, we have developed a comprehensive an

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Li, He-Yi, and 李和益. "A Knowledge Discovery Platform for Analyzing and Detecting Adverse Drug Reactions." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/92052678864206598745.

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碩士<br>國立高雄大學<br>資訊工程學系碩士班<br>97<br>Adverse Drug Reaction (ADR) is one of the most important issues on drug safety assessment and should not be ignored. In fact, many adverse drug reactions cannot be discovered through limited pre-marketing clinical trials. Instead, they can only be recognized by a long term of post-marketing surveillance of drug usages. In light of this, how to detect adverse drug reactions as early as possible is thus an important research topic in the pharmaceutical industry. Recently, the accumulation of large volumes of adverse events and the flourish of data mining techno

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Chuang, Kai-Mei, and 莊凱嵋. "Study on the platform development for hair follicle related drug discovery." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/a62hdy.

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碩士<br>國立陽明大學<br>生物藥學研究所<br>100<br>The hair follicle is a small and dynamic organ which periodically synthesizes hair. Skin and hair which cover the human body do help to keep the internal temperature regulated and to provide physical protection. The quality of hair is the most important factor in determining the appearance of age. Recently, there has been an increasing number of people suffering from alopecia and hair graying. Although these hair diseases do not appear to cause direct physical harm, hair loss or graying can psychologically affect the individual and influence others' perception

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Pinto, Miguel Ângelo Machado. "Customer discovery process on a multi-sided web platform mentform practical case." Master's thesis, 2017. http://hdl.handle.net/10362/22915.

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Startups face enormous challenges, especially in the process between having an idea and transforming it into a real business. In order to successfully launch a startup, it is key that the founders understand the Customer Development process. This knowledge will allow them to develop a more accurate product/service when the scaling phase is achieved. This thesis will study existing generic literature on startup Customer Development processes and specific literature on Multi-Sided Web Platforms (MSWP). A practical case based on Mentform -a seed stage MSWP- will then be presented and the learning

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